CN1362118A - Nano liushen medicine and its preparation - Google Patents
Nano liushen medicine and its preparation Download PDFInfo
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- CN1362118A CN1362118A CN 01100171 CN01100171A CN1362118A CN 1362118 A CN1362118 A CN 1362118A CN 01100171 CN01100171 CN 01100171 CN 01100171 A CN01100171 A CN 01100171A CN 1362118 A CN1362118 A CN 1362118A
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- 239000003814 drug Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 13
- 206010004542 Bezoar Diseases 0.000 claims abstract description 10
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 40
- 241000269417 Bufo Species 0.000 claims description 9
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 9
- 244000293323 Cosmos caudatus Species 0.000 claims description 9
- 241000402754 Erythranthe moschata Species 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 206010044008 tonsillitis Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010039587 Scarlet Fever Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Liushen preparation medicine. It is made up by using the Chinese medicinal materials of nano pearl powder, nano bovine bezoar, nano mush, nano realgar, nano bnreol and nano dried toad as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet dspray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most is grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of refreshing and detoxicating, anti-inflammatory analgetic, be used for nanometer six Miraculous drug medicines of scarlet fever, acute throat trouble, tonsillitis, laryngopharynx swelling and pain, carbuncle furuncle, the invention still further relates to the method for this medication preparation.
LIUSHEN WAN is a kind of classical Chinese patent medicine, mainly contains effects such as antiinflammatory, heart tonifying, detoxifcation, analgesia, is used for scarlet fever, acute throat trouble, tonsillitis, laryngopharynx swelling and pain, nameless galls such as carbuncle furuncle.But traditional LIUSHEN WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully nanometer six Miraculous drug medicines of increase evident in efficacy.
Another object of the present invention provides the preparation method of these nanometer six Miraculous drug medicines.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Margarita powder 5-50 part nano bezoar 1-10 part nano musk 1-10 part
Nanometer-size realgar 1-15 part nanometer Borneolum Syntheticum 1-12 part nanometer Bufo siccus 3-15 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Margarita powder 10-30 part nano bezoar 3-8 part nano musk 3-8 part
Nanometer-size realgar 3-9 part nanometer Borneolum Syntheticum 3-8 part nanometer Bufo siccus 5-12 part
The optimum weight proportioning of medicine of the present invention is:
5 parts of 5 parts of nano musks of 20 parts of nano bezoars of nanometer Margarita powder
8 parts of 5 parts of nanometer Bufo siccuss of 5 parts of nanometer Borneolum Syntheticums of nanometer-size realgar
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get six refreshing preparation nano powders with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer six Miraculous drug medicines is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common LIUSHEN WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer six Miraculous drug medicines etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for pharyngolaryngitis, tonsillitis, and diphtheria, toothache, red pain, heart failure, leukemia, treatment of conditions such as oral mucosa anesthesia, clinical efficacy significantly is better than traditional LIUSHEN WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
5 parts of 5 parts of nano musks of 20 parts of nano bezoars of nanometer Margarita powder
8 parts of 5 parts of nanometer Bufo siccuss of 5 parts of nanometer Borneolum Syntheticums of nanometer-size realgar
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
5 parts of 5 parts of nano musks of 20 parts of nano bezoars of nanometer Margarita powder
8 parts of 5 parts of nanometer Bufo siccuss of 5 parts of nanometer Borneolum Syntheticums of nanometer-size realgar
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer six refreshing powder needle injections, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
5 parts of 5 parts of nano musks of 20 parts of nano bezoars of nanometer Margarita powder
8 parts of 5 parts of nanometer Bufo siccuss of 5 parts of nanometer Borneolum Syntheticums of nanometer-size realgar
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer six refreshing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: cervical region.
Claims (6)
1, a kind of nanometer six Miraculous drug medicines is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Margarita powder 5-50 part nano bezoar 1-10 part nano musk 1-10 part
Nanometer-size realgar 1-15 part nanometer Borneolum Syntheticum 1-12 part nanometer Bufo siccus 3-15 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer six Miraculous drug medicines according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Margarita powder 10-30 part nano bezoar 3-8 part nano musk 3-8 part
Nanometer-size realgar 3-9 part nanometer Borneolum Syntheticum 3-8 part nanometer Bufo siccus 5-12 part
3, nanometer six Miraculous drug medicines according to claim 1, wherein the weight proportion of each nano raw material is:
5 parts of 5 parts of nano musks of 20 parts of nano bezoars of nanometer Margarita powder
8 parts of 5 parts of nanometer Bufo siccuss of 5 parts of nanometer Borneolum Syntheticums of nanometer-size realgar
4, according to claim 1 or 2 or 3 described nanometer six Miraculous drug medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer six Miraculous drug medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100171 CN1362118A (en) | 2001-01-04 | 2001-01-04 | Nano liushen medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100171 CN1362118A (en) | 2001-01-04 | 2001-01-04 | Nano liushen medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362118A true CN1362118A (en) | 2002-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100171 Pending CN1362118A (en) | 2001-01-04 | 2001-01-04 | Nano liushen medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362118A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670700A (en) * | 2012-05-10 | 2012-09-19 | 梁钦 | Chinese medicinal health-care medicament for arousing brain and inducing resuscitation |
-
2001
- 2001-01-04 CN CN 01100171 patent/CN1362118A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670700A (en) * | 2012-05-10 | 2012-09-19 | 梁钦 | Chinese medicinal health-care medicament for arousing brain and inducing resuscitation |
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| WD01 | Invention patent application deemed withdrawn after publication |