CN1362100A - Nano Jiuhua medicine and its preparation - Google Patents
Nano Jiuhua medicine and its preparation Download PDFInfo
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- CN1362100A CN1362100A CN 01100116 CN01100116A CN1362100A CN 1362100 A CN1362100 A CN 1362100A CN 01100116 CN01100116 CN 01100116 CN 01100116 A CN01100116 A CN 01100116A CN 1362100 A CN1362100 A CN 1362100A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 11
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 229910021538 borax Inorganic materials 0.000 claims abstract description 5
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 27
- 241001644295 Fritillaria przewalskii Species 0.000 claims description 8
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000000829 suppository Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000605372 Fritillaria Species 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000011505 plaster Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010002153 Anal fissure Diseases 0.000 description 2
- 208000016583 Anus disease Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000009531 Fissure in Ano Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a nano Jiuhua preparation medicine. It is made up by using the Chiense medicine material of nano talcum, nano borax, nano sichuan fritillaria, nano vermilion, nano dragon bone and nano borneol as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nanometer jiuhua plaster preparation medicine that a kind of anti-inflammatory analgetic, promoting regeneration of the tissue and arresting bleeding, detumescence, circulation of qi promoting life are carried, the invention still further relates to the method for this medication preparation.
Jiuhua plaster is a kind of classical Chinese patent medicine, mainly contains antiinflammatory, detumescence, hemostasis, reaches effects such as antibacterial, is used for diseases such as all kinds hemorrhoid, anal fissure.But traditional jiuhua plaster absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer nine magnificent preparation medicines of increase evident in efficacy.
Another object of the present invention provides the preparation method of these nanometer nine magnificent preparation medicines.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 3-9 part of nanomete talc powder 140-300 part nanometer Borax 20-65 part nano Sichuan fritillary bulb
Nanometer Vermilion 3-9 part nanometer Os Draconis 25-70 part nanometer Borneolum Syntheticum 3-9 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 5-8 part of nanomete talc powder 150-250 part nanometer Borax 30-45 part nano Sichuan fritillary bulb
Nanometer Vermilion 5-8 part nanometer Os Draconis 35-50 part nanometer Borneolum Syntheticum 5-8 part
The optimum weight proportioning of medicine of the present invention is:
Female 6.3 parts of 31.2 parts of nano Sichuan fritillary bulbs of 208.3 parts of nanometer Boraxs of nanomete talc powder
6.3 parts of 41.6 parts of nanometer Borneolum Syntheticums of 6.3 parts of nanometer Os Draconis of nanometer Vermilion
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get nine magnificent preparation nano powders with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer nine magnificent preparation medicines is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common jiuhua plaster preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nanometer nine magnificent preparation medicines etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for all kinds anal fissure, blood stasis, and treatment of conditions such as withered hemorrhoid postoperative patient, and clinical efficacy significantly is better than traditional jiuhua plaster.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
Female 6.3 parts of 31.2 parts of nano Sichuan fritillary bulbs of 208.3 parts of nanometer Boraxs of nanomete talc powder
6.3 parts of 41.6 parts of nanometer Borneolum Syntheticums of 6.3 parts of nanometer Os Draconis of nanometer Vermilion
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent suppository standard, do not add adjuvant, make suppository, every nine magnificent bolt content of dispersion is the 0.1-0.6 gram, and the patient uses 1-4 time every day.
Embodiment 2:
Prepare nano raw material by preceding method:
Female 6.3 parts of 31.2 parts of nano Sichuan fritillary bulbs of 208.3 parts of nanometer Boraxs of nanomete talc powder
6.3 parts of 41.6 parts of nanometer Borneolum Syntheticums of 6.3 parts of nanometer Os Draconis of nanometer Vermilion
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer nine magnificent membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part
Claims (5)
1, a kind of nanometer nine magnificent preparation medicines is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 3-9 part of nanomete talc powder 140-300 part nanometer Borax 20-65 part nano Sichuan fritillary bulb
Nanometer Vermilion 3-9 part nanometer Os Draconis 25-70 part nanometer Borneolum Syntheticum 3-9 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer nine magnificent preparation medicines according to claim 1, wherein the weight proportion of each nano raw material is:
The female 5-8 part of nanomete talc powder 150-250 part nanometer Borax 30-45 part nano Sichuan fritillary bulb
Nanometer Vermilion 5-8 part nanometer Os Draconis 35-50 part nanometer Borneolum Syntheticum 5-8 part
3 nanometer nine magnificent preparation medicines according to claim 1, wherein the weight proportion of each nano raw material is:
Female 6.3 parts of 31.2 parts of nano Sichuan fritillary bulbs of 208.3 parts of nanometer Boraxs of nanomete talc powder
6.3 parts of 41.6 parts of nanometer Borneolum Syntheticums of 6.3 parts of nanometer Os Draconis of nanometer Vermilion
4, according to claim 1 or 2 or 3 described nanometer nine magnificent preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer nine magnificent preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100116 CN1362100A (en) | 2001-01-05 | 2001-01-05 | Nano Jiuhua medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100116 CN1362100A (en) | 2001-01-05 | 2001-01-05 | Nano Jiuhua medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362100A true CN1362100A (en) | 2002-08-07 |
Family
ID=4651312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100116 Pending CN1362100A (en) | 2001-01-05 | 2001-01-05 | Nano Jiuhua medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362100A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512444A (en) * | 2011-12-02 | 2012-06-27 | 内蒙古医学院 | Preparation method for mongolian medicine vermilion nanometer powder |
| CN103099938A (en) * | 2012-10-08 | 2013-05-15 | 天津金耀集团有限公司 | Jiuhua plaster |
| CN103417785A (en) * | 2013-08-26 | 2013-12-04 | 程庸堂 | Traditional Chinese medicine ointment curing hemorrhoids |
-
2001
- 2001-01-05 CN CN 01100116 patent/CN1362100A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512444A (en) * | 2011-12-02 | 2012-06-27 | 内蒙古医学院 | Preparation method for mongolian medicine vermilion nanometer powder |
| CN102512444B (en) * | 2011-12-02 | 2014-10-29 | 内蒙古医学院 | Preparation method for mongolian medicine vermilion nanometer powder |
| CN103099938A (en) * | 2012-10-08 | 2013-05-15 | 天津金耀集团有限公司 | Jiuhua plaster |
| CN103099938B (en) * | 2012-10-08 | 2014-10-22 | 天津金耀集团有限公司 | Jiuhua plaster |
| CN103417785A (en) * | 2013-08-26 | 2013-12-04 | 程庸堂 | Traditional Chinese medicine ointment curing hemorrhoids |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |