CN1362162A - Nano Niaoganning medicine and its preparation - Google Patents
Nano Niaoganning medicine and its preparation Download PDFInfo
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- CN1362162A CN1362162A CN 01100317 CN01100317A CN1362162A CN 1362162 A CN1362162 A CN 1362162A CN 01100317 CN01100317 CN 01100317 CN 01100317 A CN01100317 A CN 01100317A CN 1362162 A CN1362162 A CN 1362162A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241001072382 Glechoma Species 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 208000000143 urethritis Diseases 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 244000025254 Cannabis sativa Species 0.000 claims description 5
- 241000405217 Viola <butterfly> Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000218229 Humulus japonicus Species 0.000 abstract 1
- 241000737263 Lygodium Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 208000019206 urinary tract infection Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Niaoganning preparation medicine. It is made up by using the Chinese medicinal materials of nano lygodium, nano glechoma, nano phoenix-tail fern, nano Japanese hop and nano ydeo violet as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is hign in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, treating stranguria sharp heat, anti-inflammation, the nanometer preparation for treating urethral infection medicine for the treatment of acute and chronic urinary tract infection the invention still further relates to the method for this medication preparation.
NIAOGANNING CHONGJI is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, treating stranguria sharp heat, anti-inflammation, is used for the acute and chronic urinary tract infection.But traditional NIAOGANNING CHONGJI disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer preparation for treating urethral infection medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer preparation for treating urethral infection medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba lygodii 60-140 part nanometer Herba Glechomae 60-140 part nanometer Herba Pteridis Multifidae 60-140 part
Nanometer is restrained careless 60-140 part nanometer Herba Violae 60-140 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba lygodii 60-140 part nanometer Herba Glechomae 60-140 part nanometer Herba Pteridis Multifidae 60-140 part
Nanometer is restrained careless 60-140 part nanometer Herba Violae 60-140 part
The best important proportioning of medicine of the present invention is:
100 parts of 100 parts of nanometer Herba Pteridis Multifidaes of 100 parts of nanometer Herba Glechomaes of nanometer Herba lygodii
100 parts of 100 parts of nanometer Herba Violaes of nanometer rule grass
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the preparation for treating urethral infection nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common NIAOGANNING CHONGJI preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer preparation for treating urethral infection medicine is identical.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer preparation for treating urethral infection medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as acute and chronic urinary tract infection, and clinical efficacy significantly is better than traditional NIAOGANNING CHONGJI.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Herba Pteridis Multifidaes of 100 parts of nanometer Herba Glechomaes of nanometer Herba lygodii
100 parts of 100 parts of nanometer Herba Violaes of nanometer rule grass
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Herba Pteridis Multifidaes of 100 parts of nanometer Herba Glechomaes of nanometer Herba lygodii
100 parts of 100 parts of nanometer Herba Violaes of nanometer rule grass
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the peaceful powder needle injection of nanometer urine sense, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Herba Pteridis Multifidaes of 100 parts of nanometer Herba Glechomaes of nanometer Herba lygodii
100 parts of 100 parts of nanometer Herba Violaes of nanometer rule grass
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the peaceful membrane of nanometer urine sense, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, waist.
Claims (6)
1, a kind of nanometer preparation for treating urethral infection medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba lygodii 60-140 part nanometer Herba Glechomae 60-140 part nanometer Herba Pteridis Multifidae 60-140 part
Nanometer is restrained careless 60-140 part nanometer Herba Violae 60-140 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer preparation for treating urethral infection medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba lygodii 60-140 part nanometer Herba Glechomae 60-140 part nanometer Herba Pteridis Multifidae 60-140 part
Nanometer is restrained careless 60-140 part nanometer Herba Violae 60-140 part
3, nanometer preparation for treating urethral infection medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 100 parts of nanometer Herba Pteridis Multifidaes of 100 parts of nanometer Herba Glechomaes of nanometer Herba lygodii
100 parts of 100 parts of nanometer Herba Violaes of nanometer rule grass
4, according to claim 1 or 2 or 3 described nanometer preparation for treating urethral infection medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer preparation for treating urethral infection medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100317 CN1362162A (en) | 2001-01-02 | 2001-01-02 | Nano Niaoganning medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100317 CN1362162A (en) | 2001-01-02 | 2001-01-02 | Nano Niaoganning medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362162A true CN1362162A (en) | 2002-08-07 |
Family
ID=4651486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100317 Pending CN1362162A (en) | 2001-01-02 | 2001-01-02 | Nano Niaoganning medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362162A (en) |
-
2001
- 2001-01-02 CN CN 01100317 patent/CN1362162A/en active Pending
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |