CN1362156A - Nano Four-Miraculous drug medicine and its preparation - Google Patents
Nano Four-Miraculous drug medicine and its preparation Download PDFInfo
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- CN1362156A CN1362156A CN 01100311 CN01100311A CN1362156A CN 1362156 A CN1362156 A CN 1362156A CN 01100311 CN01100311 CN 01100311 CN 01100311 A CN01100311 A CN 01100311A CN 1362156 A CN1362156 A CN 1362156A
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- 239000003814 drug Substances 0.000 title claims abstract description 58
- 229940079593 drug Drugs 0.000 title claims description 32
- 238000002360 preparation method Methods 0.000 title description 9
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241001446509 Psoralea Species 0.000 claims abstract description 6
- 241001078983 Tetradium ruticarpum Species 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000270834 Myristica fragrans Species 0.000 abstract 1
- 235000009421 Myristica fragrans Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 239000001702 nutmeg Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 7
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 206010067715 Gastrointestinal sounds abnormal Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a nano Sishen perparation medicine. It is made up by using the Chinese medicinal materials of nano nutmeg, nano, evodia, nano psoralea, nano schisandra, nano dried ginger and nano jujube as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of help kidney cold expelling, antidiarrheal relieving distension, the nano Four-Miraculous drug medicine that curing mainly suffers from a deficiency of the kidney catches cold the invention still further relates to the method for this medication preparation.
SISHEN WAN is a kind of classical Chinese patent medicine, mainly contains and regulate the activity of intestinal smooth muscle, strengthens effects such as digestive system function, be used to suffer from a deficiency of the kidney catch cold, the borborygmus tripe expands, half congealedly just before dawn rush down, food is not changed, incessant chronic diarrhea, yellowish complexion body are thin.But traditional SISHEN WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Four-Miraculous drug medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Four-Miraculous drug medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Semen Myristicae 120-280 part nanometer Fructus Evodiae 60-140 part nanometer Fructus Psoraleae 240-560 part
Nanometer Fructus Schisandrae Chinensis 120-280 part nanometer Rhizoma Zingiberis 60-140 part nanometer Fructus Jujubae 120-280 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Semen Myristicae 160-240 part nanometer Fructus Evodiae 80-120 part nanometer Fructus Psoraleae 320-480 part
Nanometer Fructus Schisandrae Chinensis 160-240 part nanometer Rhizoma Zingiberis 80-120 part nanometer Fructus Jujubae 160-240 part
The optimum weight proportioning of medicine of the present invention is:
400 parts of 100 parts of nanometer Fructus Psoraleaes of 200 parts of nanometer Fructus Evodiaes of nanometer Semen Myristicae
200 parts in 100 portions of nanometer Fructus Jujubaes of 200 parts of nanometer Rhizoma Zingiberiss of nanometer Fructus Schisandrae Chinensis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since nano material special construction---the material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get four refreshing preparation nano powders with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Four-Miraculous drug medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common SISHEN WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Four-Miraculous drug medicine etc. is had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for having loose bowels just before dawn, chronic diarrhea, nonspecific colonitis, deficiency and coldness constipation, the enuresis, spermatorrhea, clinical efficacy significantly is better than traditional SISHEN WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
400 parts of 100 parts of nanometer Fructus Psoraleaes of 200 parts of nanometer Fructus Evodiaes of nanometer Semen Myristicae
200 parts in 100 portions of nanometer Fructus Jujubaes of 200 parts of nanometer Rhizoma Zingiberiss of nanometer Fructus Schisandrae Chinensis
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
400 parts of 100 parts of nanometer Fructus Psoraleaes of 200 parts of nanometer Fructus Evodiaes of nanometer Semen Myristicae
200 parts in 100 portions of nanometer Fructus Jujubaes of 200 parts of nanometer Rhizoma Zingiberiss of nanometer Fructus Schisandrae Chinensis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer four refreshing powder needle injections, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
400 parts of 100 parts of nanometer Fructus Psoraleaes of 200 parts of nanometer Fructus Evodiaes of nanometer Semen Myristicae
200 parts in 100 portions of nanometer Fructus Jujubaes of 200 parts of nanometer Rhizoma Zingiberiss of nanometer Fructus Schisandrae Chinensis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer four refreshing membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano Four-Miraculous drug medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Semen Myristicae 120-280 part nanometer Fructus Evodiae 60-140 part nanometer Fructus Psoraleae 240-560 part
Nanometer Fructus Schisandrae Chinensis 120-280 part nanometer Rhizoma Zingiberis 60-140 part nanometer Fructus Jujubae 120-280 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Four-Miraculous drug medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Semen Myristicae 160-240 part nanometer Fructus Evodiae 80-120 part nanometer Fructus Psoraleae 320-480 part
Nanometer Fructus Schisandrae Chinensis 160-240 part nanometer Rhizoma Zingiberis 80-120 part nanometer Fructus Jujubae 160-240 part
3, nano Four-Miraculous drug medicine according to claim 1, wherein the weight proportion of each nano raw material is:
400 parts of 100 parts of nanometer Fructus Psoraleaes of 200 parts of nanometer Fructus Evodiaes of nanometer Semen Myristicae
200 parts in 100 portions of nanometer Fructus Jujubaes of 200 parts of nanometer Rhizoma Zingiberiss of nanometer Fructus Schisandrae Chinensis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Four-Miraculous drug medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Four-Miraculous drug medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100311 CN1362156A (en) | 2001-01-02 | 2001-01-02 | Nano Four-Miraculous drug medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100311 CN1362156A (en) | 2001-01-02 | 2001-01-02 | Nano Four-Miraculous drug medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362156A true CN1362156A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100311 Pending CN1362156A (en) | 2001-01-02 | 2001-01-02 | Nano Four-Miraculous drug medicine and its preparation |
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| Country | Link |
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| CN (1) | CN1362156A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327596A (en) * | 2011-10-25 | 2012-01-25 | 陈桢皓 | Chinese medicinal composition for treating urinary incontinence |
| CN105343855A (en) * | 2015-12-11 | 2016-02-24 | 齐鲁工业大学 | Traditional Chinese medicine composition with intestine stabilizing and diarrhea stopping function |
| CN112587579A (en) * | 2021-01-11 | 2021-04-02 | 江西中医药大学 | Traditional Chinese medicine volatile oil composition for treating ulcerative colitis and preparation method and application thereof |
-
2001
- 2001-01-02 CN CN 01100311 patent/CN1362156A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327596A (en) * | 2011-10-25 | 2012-01-25 | 陈桢皓 | Chinese medicinal composition for treating urinary incontinence |
| CN105343855A (en) * | 2015-12-11 | 2016-02-24 | 齐鲁工业大学 | Traditional Chinese medicine composition with intestine stabilizing and diarrhea stopping function |
| CN112587579A (en) * | 2021-01-11 | 2021-04-02 | 江西中医药大学 | Traditional Chinese medicine volatile oil composition for treating ulcerative colitis and preparation method and application thereof |
| CN112587579B (en) * | 2021-01-11 | 2022-09-23 | 江西中医药大学 | A kind of traditional Chinese medicine volatile oil composition for treating ulcerative colitis and its preparation method and application |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |