CN1358841A - Yunnan streptin - Google Patents
Yunnan streptin Download PDFInfo
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- CN1358841A CN1358841A CN 00134062 CN00134062A CN1358841A CN 1358841 A CN1358841 A CN 1358841A CN 00134062 CN00134062 CN 00134062 CN 00134062 A CN00134062 A CN 00134062A CN 1358841 A CN1358841 A CN 1358841A
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- 108010043542 streptin Proteins 0.000 title claims description 12
- 238000000855 fermentation Methods 0.000 claims abstract description 7
- 230000004151 fermentation Effects 0.000 claims abstract description 7
- 241000025428 Streptomyces yunnanensis Species 0.000 claims abstract description 3
- 239000012153 distilled water Substances 0.000 claims description 9
- 238000011218 seed culture Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 6
- 229940041514 candida albicans extract Drugs 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000001963 growth medium Substances 0.000 claims description 6
- 238000012807 shake-flask culturing Methods 0.000 claims description 6
- 239000012138 yeast extract Substances 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 5
- 229920001817 Agar Polymers 0.000 claims description 3
- 239000004254 Ammonium phosphate Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- 239000001888 Peptone Substances 0.000 claims description 3
- 108010080698 Peptones Proteins 0.000 claims description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
- 239000006035 Tryptophane Substances 0.000 claims description 3
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 3
- 239000008272 agar Substances 0.000 claims description 3
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims description 3
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 3
- 229940000635 beta-alanine Drugs 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002054 inoculum Substances 0.000 claims description 3
- 235000012204 lemonade/lime carbonate Nutrition 0.000 claims description 3
- 235000019319 peptone Nutrition 0.000 claims description 3
- 229960004799 tryptophan Drugs 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 241000186361 Actinobacteria <class> Species 0.000 abstract description 4
- 230000000843 anti-fungal effect Effects 0.000 abstract description 2
- 230000002906 microbiologic effect Effects 0.000 abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 description 6
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical class C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000001857 anti-mycotic effect Effects 0.000 description 2
- 239000011504 laterite Substances 0.000 description 2
- 229910001710 laterite Inorganic materials 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to the field of microbiological technology, in particular it relates to a new actinomycetes. Said invention is a streptomyces yunnanensis, its preserved registration number is CGMCC No.0509. Said invented actinomycetes can utilize microbiological fermentation and liquid phase chromatographic preparation method to obtain new optical type cycloheximides compound. Said compound possesses strong antifungal activity, and its yield rate can be up to 0.04%.
Description
The present invention relates to microbial technology field, specifically relate to novel species actinomycetes.
The cycloheximide compounds, has anti-mycotic activity, this compounds mainly is to obtain by the microbial fermentation approach, and being widely used in a plurality of fields such as agricultural antibiotic, the biochemical and medical manufacturing of experiment, existing cycloheximide compounds (as actidione) mainly is to obtain by the microbial fermentation approach.Along with the understanding of the mankind, need this compounds of more anti-various fungies to fungi.
The purpose of this invention is to provide a kind of novel species actinomycetes---Yunnan streptin that can produce new cycloheximide compounds with anti-mycotic activity.
Yunnan streptin of the present invention, its called after Yunnan streptin (streptomycesyunnanensis), its preservation registration number is CGMCC NO.0509.
Gather in the laterite of Yunnan streptin system of the present invention by suburb, Kunming, Yunnan, obtain in the laboratory separation and Culture, this bacterial strain is in the preservation of specified depositary institution of Patent Office of State Intellectual Property Office, and preservation date is on November 19th, 2000, and preservation registration number is CGMCC NO.0509.The morphological specificity of bacterial strain is that gas silk and base silk are flourishing, and the base silk does not rupture; Spore chain length, twist; Many wrinkles in spore (diameter 0.5-10 μ m) surface and the short thorn of band.Cytochemistry: cell walls contains LL-DAP and glycine: full cell hydrolyzed solution contains semi-lactosi.
Culture condition:
(1) slant culture: cultivated 7 days.Substratum: glucose 1-5g, yeast extract paste 1-5g, malt extract 1-5g, vitamin complex 3.75mg/L, agar 15-20g, distilled water 1000ml, PH7.2;
(2) seed culture: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 50-160g, soyflour 10-50g, yeast extract paste 0.5-5g, tryptophane 0.1-2g, Beta-alanine 1-6g, sal epsom 0.1-2g, ammonium phosphate 0.1-2g, distilled water 1000ml, PH7.2:
(3) fermentation: the inoculum size by 10% inserts in the seed culture medium, shake-flask culture 6 days.Substratum: soyflour 1-20g, glucose 1-25g, peptone 1-10, sodium-chlor 0.1-5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
16SrDNA：ataccttgttacgacttcgtcccaatcgccagtcccaccttcgacgattccctcccacaaggggttgggccaccggcttcgggtgttaccgactttcgtgacgtgacgggcggtgtgtacaaggcccgggaacgtattcaccgcagcaatgctgatctgcgattactagcaactccgacttcatggggtcgagttgcagaccccaatccgaactgagaccggctttttgagattcgctccacctcgcggtatcgcagctcattgtaccggccattgtagcacgtgtgcagcccaagacataaggggcatgatgacttgacgtcgtccccaccttcctccgagttgaccccggcagtctcctgtgagtccccatcaccccgaaaggcatgctggcaacacagaacaagggttgcgctcgttgcgggacttaacccaacatctcacgacacgagctgacgacagccatgcaccacctgtacaccgaccacaagggggaccctatctctaatgctttccggtgtatgtcaagccttggtaaggttcttcgcgttgcgtcgaattaagccacatgctccgatgcttgtgcgggcccccgtcaattcctttgagttttagccttgcggccgtactccccaggcggggaacttaatgcgttagctgcggcacggacgacgtggaatgtcgcccacacctagttcccaacgtttacggcgtggactaccagggtatctaatcctgttcgctccccacgctttcgctcctcagcgtcagtatcggcccagagatccgccttcgccaccggtgttcctcctgatatctgcgcatttcaccgctacaccaggaattccgatctcccctaccgaactctagcctgcccgtatcgaatgcagacccggggttaagccccgggctttcacatccgacgtgacaagccgcctacgagctctttacgcccaataattccggacaacgctcgcgccctacgtattaccgcggctgctggcacgtagttagccggcgcttcttctgcaggtaccgtcactctcgcttcttccctgctgaaagaggtttacaacccgaaggccgtcatccctcacgcggcgtcgctgcatcaggctttcgcccattgtgcaatattccccactgctgcctcccgtaggagtctgggccgtgtctcagtcccagtgtggccggtcgccctctcaggccggctacccgtcgtcgccttggtgagccattacctcaccaacaagctgataggccgcgggctcatccttcaccgccggagctttccacacggagatcatgcgaccccgtgtcatatccggtattagaccccgtttccagggcttgtcccagagtgaagggcagattgccctcgtgttactcacccgttcgccactaatccccgaccgaagccggttcatcgttcgacttgcatgtgttaagcacgccgccagcgttcgtcctgagccaggatcaaactctgagctcgt
Fig. 1 is the bacterial strain stereoscan photograph of microorganism of the present invention.
Fig. 2 is the local magnified sweep electromicroscopic photograph of the bacterial strain of microorganism of the present invention.
Fig. 1 has shown the state of Yunnan streptin bacterial strain spore chain of the present invention, and what Fig. 2 was shown is bacterial strain The careful outward appearance of single spore on the spore chain is if any elephant skin and have short thorn.
Yunnan streptin of the present invention is novel species actinomyces, it can pass through the microbial fermentation approach, The cycloheximide compounds that the method for preparing liquid chromatography acquisition has new optically-active type, such that obtains Compound is noval chemical compound; Has strong antifungal activity, the change that utilizes microorganism of the present invention to obtain Compound productive rate height can reach 0.04 ‰.
Embodiment:
From the laterite in suburb, Kunming, Yunnan, gather soil sample, in the laboratory, cultivate, can obtain actinomycetes strain Yunnan streptin YIM41004 of the present invention by following condition.
Culture condition:
(1) slant culture condition: substratum: glucose 4g, yeast extract paste 4g, malt extract 5g, vitamin complex 3.75mg/L, agar 15g, distilled water 1000ml, PH7.2; Cultivated 7 days;
(2) seed culture condition: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 120g, soyflour 40g, yeast extract paste 2g, tryptophane 0.5g, Beta-alanine 5g, sal epsom 0.5g, ammonium phosphate 0.2g, distilled water 1000ml, PH7.2;
(3) fermentation culture conditions: receive in the seed culture medium shake-flask culture 6 days by 10% inoculum size.Substratum: soyflour 10g, glucose 10g, peptone 3g, sodium-chlor 2.5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
Claims (3)
1, a kind of Yunnan streptin is characterized in that called after Yunnan streptin (streptomycesyunnanensis), and its preservation registration number is CGMCC NO.0509.
2,, it is characterized in that culture condition is according to the described Yunnan streptin of claim 1:
(1) slant culture: cultivated 7 days.Substratum: glucose 1-5g, yeast extract paste 1-5g, malt extract 1-5g, vitamin complex 3.75mg/L, agar 15-20g, distilled water 1000ml, PH7.2;
(2) seed culture: insert the seed liquor shake-flask culture 36 hours from inclined-plane picking part mycelium.Seed culture medium: dextrin 50-160g, soyflour 10-50g, yeast extract paste 0.5-5g, tryptophane 0.1-2g, Beta-alanine 1-6g, sal epsom 0.1-2g, ammonium phosphate 0.1-2g, distilled water 1000ml, PH7.2;
(3) fermentation: the inoculum size by 10% inserts in the seed culture medium, shake-flask culture 6 days.Substratum: soyflour 1-20g, glucose 1-25g, peptone 1-10, sodium-chlor 0.1-5g, lime carbonate 2g, distilled water 1000ml, PH7.2.
3、1,16SrDNA：ataccttgttacgacttcgtcccaatcgccagtcccaccttcgacgattccctcccacaaggggttgggccaccggcttcgggtgttaccgactttcgtgacgtgacgggcggtgtgtacaaggcccgggaacgtattcaccgcagcaatgctgatctgcgattactagcaactccgacttcatggggtcgagttgcagaccccaatccgaactgagaccggctttttgagattcgctccacctcgcggtatcgcagctcattgtaccggccattgtagcacgtgtgcagcccaagacataaggggcatgatgacttgacgtcgtccccaccttcctccgagttgaccccggcagtctcctgtgagtccccatcaccccgaaaggcatgctggcaacacagaacaagggttgcgctcgttgcgggacttaacccaacatctcacgacacgagctgacgacagccatgcaccacctgtacaccgaccacaagggggaccctatctctaatgctttccggtgtatgtcaagccttggtaaggttcttcgcgttgcgtcgaattaagccacatgctccgatgcttgtgcgggcccccgtcaattcctttgagttttagccttgcggccgtactccccaggcggggaacttaatgcgttagctgcggcacggacgacgtggaatgtcgcccacacctagttcccaacgtttacggcgtggactaccagggtatctaatcctgttcgctccccacgctttcgctcctcagcgtcagtatcggcccagagatccgccttcgccaccggtgttcctcctgatatctgcgcatttcaccgctacaccaggaattccgatctcccctaccgaactctagcctgcccgtatcgaatgcagacccggggttaagccccgggctttcacatccgacgtgacaagccgcctacgagctctttacgcccaataattccggacaacgctcgcgccctacgtattaccgcggctgctggcacgtagttagccggcgcttcttctgcaggtaccgtcactctcgcttcttccctgctgaaagaggtttacaacccgaaggccgtcatccctcacgcggcgtcgctgcatcaggctttcgcccattgtgcaatattccccactgctgcctcccgtaggagtctgggccgtgtctcagtcccagtgtggccggtcgccctctcaggccggctacccgtcgtcgccttggtgagccattacctcaccaacaagctgataggccgcgggctcatccttcaccgccggagctttccacacggagatcatgcgaccccgtgtcatatccggtattagaccccgtttccagggcttgtcccagagtgaagggcagattgccctcgtgttactcacccgttcgccactaatccccgaccgaagccggttcatcgttcgacttgcatgtgttaagcacgccgccagcgttcgtcctgagccaggatcaaactctgagctcgt
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00134062 CN1358841A (en) | 2000-12-11 | 2000-12-11 | Yunnan streptin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00134062 CN1358841A (en) | 2000-12-11 | 2000-12-11 | Yunnan streptin |
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