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CN1238999A - Magnetic cyclotron electrochemical tumor therapy device - Google Patents

Magnetic cyclotron electrochemical tumor therapy device Download PDF

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Publication number
CN1238999A
CN1238999A CN 98115303 CN98115303A CN1238999A CN 1238999 A CN1238999 A CN 1238999A CN 98115303 CN98115303 CN 98115303 CN 98115303 A CN98115303 A CN 98115303A CN 1238999 A CN1238999 A CN 1238999A
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power supply
magnetic field
magnetic
excitation power
cyclotron
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CN1121881C (en
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陈国璋
陈惠晓
余祖明
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Zhejiang Medical Sciences University
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Zhejiang Medical Sciences University
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Abstract

本发明涉及治疗肿瘤所用电化学治疗装置属医疗器械。其特征在于将直流磁场励磁电源、交变磁场励磁电源接到套在电磁铁铁芯上电磁铁线圈上,电化疗电源、高压脉冲电源及交变电源接到至少一个以上电极和中心电极上,射频电源接到中心电极上。由于增加了直流和交流磁场、脉冲电场和微波对肿瘤作用,使肿瘤组织的生物化学分子在整个肿瘤组织中作回旋运动,克服了柱状杀伤效应,提高了疗效。

The invention relates to an electrochemical treatment device used for treating tumors, which belongs to medical equipment. It is characterized in that the DC magnetic field excitation power supply and the alternating magnetic field excitation power supply are connected to the electromagnet coil on the electromagnet core, and the electrochemotherapy power supply, high-voltage pulse power supply and alternating power supply are connected to at least one electrode and the center electrode, RF power is connected to the center electrode. Due to the increase of DC and AC magnetic fields, pulsed electric fields and microwaves on the tumor, the biochemical molecules of the tumor tissue can rotate in the entire tumor tissue, which overcomes the columnar killing effect and improves the curative effect.

Description

磁回旋电化学肿瘤治疗装置Magnetic cyclotron electrochemical tumor therapy device

本发明涉及治疗肿瘤所用电化学治疗装置属医疗器械。The invention relates to an electrochemical treatment device used for treating tumors, which belongs to medical equipment.

直流电化学疗法是瑞典的放射医学专家开创的,它是在肿瘤组织上插入一对或一组电极,通以直流电流,从而在电极周围肿瘤组织发生电解、电泳、电渗等一系列的生物电化学变化,使其坏死达到抑瘤的作用。通常使用的装置是由控制板、电源、电极组成,可预置电压、电流、治疗时间。这种疗法具有创伤小、安全、简单、容易操作的优点。但是由于带电粒子在电极间作一维泳动,在其间形成固定的通道,治疗物质在肿瘤组织内不能及时地均匀分布。致使治疗区域只围绕在针的周围形成柱状杀伤效应,影响治疗效果。Direct current electrochemotherapy was pioneered by radiation medicine experts in Sweden. It inserts a pair or a group of electrodes on the tumor tissue and passes a direct current, so that a series of bioelectrical processes such as electrolysis, electrophoresis, and electroosmosis occur in the tumor tissue around the electrodes. Chemical changes make it necrotic to achieve the effect of tumor suppression. The commonly used device is composed of a control panel, a power supply, and electrodes, and the voltage, current, and treatment time can be preset. This therapy has the advantages of less trauma, safety, simplicity and easy operation. However, due to the one-dimensional swimming of charged particles between the electrodes, a fixed channel is formed between them, and the therapeutic substance cannot be uniformly distributed in the tumor tissue in time. As a result, the treatment area only forms a columnar killing effect around the needle, which affects the treatment effect.

本发明的目的是要提供一种在肿瘤周围增加磁场、高压脉冲电场、微波的磁回旋电化学肿瘤治疗装置。The object of the present invention is to provide a magnetic cyclotron electrochemical tumor treatment device that adds magnetic field, high-voltage pulse electric field and microwave around the tumor.

本发明的任务是通过以下的技术方案得到实现的:将直流磁场励磁电源、交变磁场励磁电源接到电磁铁线圈上,电磁铁线圈套在电磁铁铁芯上,交变电源、电化疗电源高压脉冲电源都至少接一个以上电极上和中心电极上,射频电源接到中心电极上。The task of the present invention is achieved through the following technical proposals: the DC magnetic field excitation power supply and the alternating magnetic field excitation power supply are connected to the electromagnet coil, the electromagnet coil is sleeved on the electromagnet core, the alternating power supply, the electrochemotherapy power supply The high-voltage pulse power supply is connected to at least one electrode and the center electrode, and the radio frequency power supply is connected to the center electrode.

本发明对现有的电化学治疗仪进行了改进,增加了直流和交流磁场、脉冲电场和微波对肿瘤作用,使肿瘤组织中在电极间泳动的离子和带电粒子同时又在在垂直于磁场的方向上以中心电极为轴心,在整个肿瘤组织内作回旋运动,带电粒子在其周围吸引了不同数量的水及其它极性分子,并带动了电化学治疗物一起作回旋运动,克服了电化疗的不足之处。按一定要求交替加入的交变磁场和电极间的交变电场能加强磁回旋运动,这不仅能增强治疗的时空调节作用而且能提高治疗物质的利用率和治疗的有效性。按要求加入的脉冲电场和微波电磁场也都进一步增强疗效。The present invention improves the existing electrochemical therapeutic apparatus, increases the effects of DC and AC magnetic fields, pulsed electric fields and microwaves on tumors, and makes the ions and charged particles swimming between the electrodes in the tumor tissue move vertically to the magnetic field at the same time. In the direction of the center electrode as the axis, it makes a gyratory motion in the entire tumor tissue, and the charged particles attract different amounts of water and other polar molecules around it, and drive the electrochemical treatment substance to make a gyratory motion together, overcoming the Disadvantages of Electrochemotherapy. The alternating magnetic field and the alternating electric field between the electrodes can strengthen the magnetic cyclotron according to certain requirements, which can not only enhance the spatiotemporal regulation of the treatment but also improve the utilization rate of the treatment substance and the effectiveness of the treatment. The pulsed electric field and microwave electromagnetic field added as required also further enhance the curative effect.

图1本发明原理示意图Fig. 1 schematic diagram of principle of the present invention

图2本发明实施例结构示意图Fig. 2 structure schematic diagram of embodiment of the present invention

以下结合附图对本发明作进一步具体的说明。The present invention will be further specifically described below in conjunction with the accompanying drawings.

图1中的直流磁场励磁电源1、交变磁场励磁电源2、通过联动开关16与电磁线圈8连接,电磁铁线圈8套在电磁铁铁芯6上,磁极头7通过磁力吸合与电磁铁铁芯6连接,磁极头7是一组几何形状不同的可根据肿瘤几何形状加以选择调换的磁极头。高压脉冲电源5、电化疗电源4都至少接一个以上电极(10、11)和中心电极9上,射频电源3接到中心电极9上,电化疗电源4、交变磁场励磁电源2、直流磁场励磁电源1之间通过联动开关16相连,以保证使用交变磁场时交变电源同时作用于电极。治疗床12是带轮的可移动的床。The DC magnetic field excitation power supply 1 and the alternating magnetic field excitation power supply 2 in Fig. 1 are connected to the electromagnetic coil 8 through the linkage switch 16, the electromagnet coil 8 is set on the electromagnet core 6, and the magnetic pole head 7 is attracted to the electromagnet by magnetic force The iron core 6 is connected, and the magnetic pole head 7 is a group of magnetic pole heads with different geometric shapes that can be selected and exchanged according to the geometric shape of the tumor. The high-voltage pulse power supply 5 and the electrochemotherapy power supply 4 are at least connected to one or more electrodes (10, 11) and the center electrode 9, the radio frequency power supply 3 is connected to the center electrode 9, the electrochemotherapy power supply 4, the alternating magnetic field excitation power supply 2, and the DC magnetic field The excitation power sources 1 are connected through a linkage switch 16 to ensure that the alternating power sources act on the electrodes at the same time when the alternating magnetic field is used. The treatment couch 12 is a movable bed on wheels.

图2中控制板13、电源箱15、轭铁14、磁极头7、磁铁线圈8、射频电源3、治疗床12、电极9和10、11、12组成磁回旋电化学肿瘤治疗装置,用于接通磁回路的轭铁14,通过控制板13与电源箱15相连,电磁铁线圈8套在电磁铁铁芯6上插入轭铁14孔中,二者可以螺纹连接以实现改变两者相对位置。治疗床的床板面下的空隙处焊有一架子,安放电化学疗恒流电源4、射频电源3、高压脉冲电源5。极磁头7是可以调换的,其与电磁铁铁芯6是通过磁力吸合,极磁头7是一组几何形状不同的磁极头。电源箱15内装有直流磁场励磁电源1、交变磁场励磁电源2。Control panel 13, power box 15, yoke iron 14, magnetic pole head 7, magnet coil 8, radio frequency power supply 3, treatment couch 12, electrode 9 and 10, 11, 12 form magnetic cyclotron electrochemical tumor treatment device in Fig. 2, for The yoke 14 connected to the magnetic circuit is connected to the power supply box 15 through the control board 13, the electromagnet coil 8 is set on the electromagnet core 6 and inserted into the hole of the yoke 14, and the two can be screwed to realize changing the relative position of the two . A shelf is welded in the gap under the bed board surface of the treatment couch, and the electro-chemical therapy constant current power supply 4, the radio frequency power supply 3, and the high voltage pulse power supply 5 are placed. The pole magnetic head 7 can be exchanged, and it and the electromagnet core 6 are attracted by magnetic force, and the pole magnetic head 7 is a group of magnetic pole heads with different geometric shapes. The DC magnetic field excitation power supply 1 and the alternating magnetic field excitation power supply 2 are housed in the power supply box 15 .

治疗时,借助导针把电极插入肿瘤组织事先确定的位置,将病人送入两磁极头7之间,通过调整治疗床、二个电磁铁铁芯相对位置使肿瘤组织暴露于两磁极头所组成的磁场气隙即治疗空间中。接通励磁电源,将磁场调至所需强度,同时接通高压脉冲电源、电化疗电源,将电流、电压压调至治疗所需值,接通射频电源,此时以电极为天线,既产生直流电流又产生一定强度的射频电磁波,到预定治疗时间,治疗完成。视肿瘤的情况可通过联动开关控制是使用直流励磁电源1还是交流励磁电源2,同时也控制电化疗电源4当使用交流励磁电源时同时将交流电源与电极接通。During treatment, the electrode is inserted into the predetermined position of the tumor tissue with the help of a guide needle, and the patient is sent between the two magnetic pole heads 7, and the tumor tissue is exposed to the two magnetic pole heads by adjusting the relative position of the treatment couch and the two electromagnet cores. The magnetic field air gap is the treatment space. Turn on the excitation power supply, adjust the magnetic field to the required strength, and at the same time turn on the high-voltage pulse power supply and electrochemotherapy power supply, adjust the current and voltage to the values required for treatment, and turn on the radio frequency power supply. The direct current generates radio frequency electromagnetic waves of a certain intensity, and the treatment is completed when the scheduled treatment time is reached. Depending on the condition of the tumor, the linkage switch can be used to control whether to use the DC excitation power supply 1 or the AC excitation power supply 2. At the same time, it also controls the electrochemotherapy power supply 4 to connect the AC power supply to the electrodes at the same time when the AC excitation power supply is used.

Claims (2)

1.一种磁回旋电化学肿瘤治疗装置包括控制板(1)、电源箱(15)、开关(16)、电极(9、10)其特征在于将直流磁场励磁电源(1)、交变磁场励磁电源(2)接到电磁铁线圈(8)上,电磁铁线圈(8)套在电磁铁铁芯(6)上,电磁铁铁芯插入轭铁(14)孔中,交变磁场励磁电源(2)、电化疗电源(4)、高压脉冲电源(5)都至少接一个以上电极(10、11)上和中心电极(9)上,射频电源(3)接到中心电极(9)上,直流磁场励磁电源(1)、交变磁场励磁电源(2)、电化疗电源(4)之间通过联动开关(16)相连。1. A magnetic cyclotron electrochemical tumor therapy device comprises a control panel (1), a power supply box (15), a switch (16), electrodes (9, 10) and is characterized in that the DC magnetic field excitation power supply (1), the alternating magnetic field The excitation power supply (2) is connected to the electromagnet coil (8), the electromagnet coil (8) is sleeved on the electromagnet core (6), the electromagnet core is inserted into the hole of the yoke (14), and the alternating magnetic field excitation power supply (2), electrochemotherapy power supply (4), high-voltage pulse power supply (5) are all connected at least on more than one electrode (10,11) and on the center electrode (9), radio frequency power supply (3) is connected on the center electrode (9) , the DC magnetic field excitation power supply (1), the alternating magnetic field excitation power supply (2), and the electrochemotherapy power supply (4) are connected through a linkage switch (16). 2.如权利要求1所述的磁回旋电化学肿瘤治疗装置的电磁铁铁芯(6)其特征在于与其相贴的磁极头(7)是一组几何形状不同的磁极头。2. The electromagnet core (6) of the magnetic cyclotron electrochemical tumor treatment device according to claim 1, characterized in that the magnetic pole heads (7) attached to it are a group of magnetic pole heads with different geometric shapes.
CN 98115303 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor Expired - Fee Related CN1121881C (en)

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CN 98115303 CN1121881C (en) 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor

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CN 98115303 CN1121881C (en) 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor

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CN1121881C CN1121881C (en) 2003-09-24

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960779B (en) * 2004-06-07 2010-09-08 拉亚·维亚·库玛 A method of tissue regeneration or denaturation in humans and device thereby
CN106621050A (en) * 2017-02-07 2017-05-10 浙江大学 Power-frequency electromagnetic field generating device and loading method with tumor suppressing effect

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960779B (en) * 2004-06-07 2010-09-08 拉亚·维亚·库玛 A method of tissue regeneration or denaturation in humans and device thereby
CN106621050A (en) * 2017-02-07 2017-05-10 浙江大学 Power-frequency electromagnetic field generating device and loading method with tumor suppressing effect

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