CN1231250C - Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof - Google Patents

Abstract

The present invention relates to a traditional Chinese medicine preparation for treating acute pharyngitis and chronic pharyngitis and a preparing method thereof. The traditional Chinese medicine preparation is formed by preparing native achyranthes, roughhaired holly root and radix glycyrrhiza according to certain weight proportioning. The traditional Chinese medicine has the functions of clearing heat, detoxicating, relieving the throat to restore voice, promoting salivation, eliminating vexation, dispersing accumulation and dissolving stagnation. In particular, the present invention is suitable for treating swelling and pain in the throat caused by exuberant lung and stomach. The traditional Chinese preparation of the present invention has the functions of relieving fever and relieving pain, and has the pharmacological action on the prevention of inflammation. The present invention both can be used for treating acute pharyngitis and can also be used for treating chronic pharyngitis.

Description

A traditional Chinese medicine preparation for treating acute and chronic pharyngitis and its preparation method

technical field

The invention relates to a traditional Chinese medicine preparation for treating acute and chronic pharyngitis and a preparation method thereof, in particular to a pure Chinese medicinal preparation for treating acute and chronic pharyngitis made from natural Chinese herbal medicines and a preparation method thereof.

Background technique

Pharyngitis belongs to the category of "throat numbness" in traditional Chinese medicine, and is a common clinical disease and frequently-occurring disease. Pharyngitis is divided into two kinds of acute pharyngitis and chronic pharyngitis.

Acute pharyngitis is mainly due to viral, bacterial infection, or a variety of physical and chemical factors to stimulate acute congestion, swelling, pain and other inflammatory reactions in the pharyngeal mucosa, submucosal tissue, and lymphoid tissue.

Chronic pharyngitis is caused by repeated episodes of acute pharyngitis; oral and nasal cavity diseases or long-term physical and chemical stimulation and various systemic chronic phlegm diseases cause diffuse inflammation of the pharyngeal mucosa, submucosal tissue, and lymphoid tissue.

Traditional Chinese medicine puts acute and chronic pharyngitis into the category of sore throat, and believes that the pathogenesis is exogenous wind-heat, steaming the throat; Accumulation of heat, fumigation of the throat or overstrain, visceral imbalance, inflammation of the deficiency fire, and fumigation of the throat. Acute pharyngitis mostly belongs to wind-heat sore throat, and chronic pharyngitis mostly belongs to yin deficiency sore throat. Acute pharyngitis recurs and persists for a long time, causing lung and kidney yin deficiency and lack of body fluid, and then it will develop into chronic pharyngitis. If left untreated for a long time, it will lead to aggravation of the disease and affect people's health.

At present, there are many commercially available medicaments for the treatment of pharyngitis, including pills, tablets, and liquid sprays. The raw materials are not the same, the compatibility is even more inconsistent, and the production methods are more complicated. Some of the prepared drugs have side effects. After long-term use of some drugs, various viruses and bacteria will develop drug resistance. Therefore, the curative effect is not satisfactory and the cure rate is not high. . Some Chinese patent medicines also have the shortcomings of treating the symptoms but not the root cause, only treating the acute, not chronic. All can not reach the purpose of radical cure as existing " winter spirit grass ", " Liushen pill ", " throat disease pill ".

Contents of the invention

The purpose of the present invention is to overcome the shortcomings of the above-mentioned existing medicines, and provide a traditional Chinese medicine preparation for treating acute and chronic pharyngitis and a preparation method thereof. It has the effect of stagnation, especially for the treatment of sore throat caused by excessive heat in the lung and stomach. The traditional Chinese medicine preparation of the invention has the pharmacological effects of antipyretic, analgesic and anti-inflammation, and can not only treat acute pharyngitis, but also treat chronic pharyngitis.

One aspect of the present invention provides a traditional Chinese medicine preparation for treating acute and chronic pharyngitis, which is prepared from Achyranthes bidentata, Glycyrrhiza officinalis and Radix Glycyrrhiza in the following proportions by weight:

Achyranthes 45-60,

Gang Megan 70-85,

Licorice 8-12.

A preferred traditional Chinese medicine preparation for treating acute and chronic pharyngitis of the present invention is prepared from Achyranthes bidentata, Radix Glycyrrhizae and Radix Glycyrrhizae according to the following proportions by weight:

Soil achyranthes 50-55,

Gang Megan 75-80,

Licorice 8-12.

The most preferred traditional Chinese medicine preparation for treating acute and chronic pharyngitis of the present invention is prepared from Achyranthes bidentata, Radix Glycyrrhizae and Radix Glycyrrhizae according to the following proportions by weight:

Soil Achyranthes 53,

Gang Megan 77,

Licorice 10.

A traditional Chinese medicine preparation for treating acute and chronic pharyngitis according to the present invention can be made into various dosage forms according to conventional methods, including oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray and pill Or drop pills, etc.

Among various dosage forms, preferably a kind of oral liquid made by following method, this preparation method is:

A. Decoct Achyranthes bidentata, Gangmeigen and licorice twice with 3-6 times the amount of water, the first time is 2-2.5 hours, and the second time is 1.5-2 hours;

B. Filter, combine the filtrates, and concentrate, add 50-60% ethanol to soak for 10-15 hours, filter, recover ethanol, add water to the required amount, and add a certain amount of preservative;

C. Subpackage into finished products.

Specific administration method and dosage: take orally, three times a day, 10-20ml each time. Acute pharyngitis is a course of treatment for 3 consecutive days, and chronic pharyngitis is a course of treatment for 7 consecutive days.

In various dosage forms, also preferably a kind of capsule made by following method, this preparation method is:

A. Mix Achyranthes bidentata, Plum Root and licorice after crude drug treatment, add 3-6 times the amount of water to boil, extract 2 times, the first time is 2-2.5 hours, and the second time is 1.5-2 hours;

B. filter, combine secondary filtrate, concentrate;

C. Add 50-60% ethanol to soak for 10-15 hours, filter, recover ethanol, concentrate the filtrate, spray dry into fine powder;

D. Add appropriate amount of starch and microcrystalline fiber to the fine powder, mix evenly, divide into capsule shells, and the finished product is formed.

All the traditional Chinese medicines in the Chinese medicine preparation of the present invention are natural medicinal materials. The Achyranthes bidentata in the prescription is astringent and slightly sweet, warm in nature and non-toxic. It is born in open fields beside roads in mountain villages, or cultivated artificially. Annual or biennial herbs. The stem is thick and upright, much branched, slightly square, more or less hairy, two or three feet high, woody at the base, knotted wood like achyranthes, opposite leaves, oval, two or three inches long, with short bristles, all green , apex pointed, base cuneate, with petiole. Spikes in summer and autumn, densely covered with downy hairs, small, green flowers, clinging to the flower axis after opening, with two hard and sharp bracts, easy to attach to clothes.

A traditional Chinese medicine preparation for treating acute and chronic pharyngitis of the present invention is prepared from three kinds of Chinese herbal medicines. No obvious disadvantages.

Detailed ways

A kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis of the present invention and its preparation method are specifically described below by using the examples.

Example 1

An oral liquid for treating acute and chronic pharyngitis, which is prepared by the following weights:

Ox knee 815 grams,

Gang Megan 1175g,

Licorice 153 grams.

The preparation technology of above-mentioned oral liquid is as follows:

A. Decoct Achyranthes bidentata, Gangmegen and licorice twice with 5 times the amount of water, the first time is 2 hours, and the second time is 2 hours;

B. Filtrate, combine the filtrate, and concentrate, add 50-60% ethanol to soak for 10-15 hours, filter, recover ethanol, add water to 1000ml; add 0.5 g of paraben;

C. Divide into 100ml.

Example 2

A medicine capsule for treating acute and chronic pharyngitis, which is prepared by the following weights:

Soil ox knee 2650 grams,

Gang Megan 3900g,

Licorice 500 grams.

The preparation technology of above-mentioned capsule is as follows:

A. Mix Achyranthes bidentata, Plum Root and Licorice after crude drug treatment, add 4 times the amount of water to boil, extract twice, the first time for 2 hours, and the second time for 2 hours;

B. filter, combine secondary filtrate, concentrate;

C. Add 50-60% ethanol to soak for 12 hours, filter, recover ethanol, concentrate the filtrate, and spray dry it into a fine powder;

D. Add appropriate amount of starch and microcrystalline fiber to the fine powder, mix evenly, divide into 1000 capsules, and pack.

Further illustrate the drug effect of a kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis of the present invention by pharmacodynamic test below:

1 Experimental materials

1.1 Drugs and reagents The traditional Chinese medicine preparation (trade name: Liyan Fang) of the present invention is provided by Guangdong Gaosheng Pharmaceutical Development Co., Ltd., and is a brown powder, and each g is equivalent to 4.8g of the original drug. Caoshanhu buccal tablets, produced by Jiangzhong Pharmaceutical Factory. Aspirin was purchased from Xuzhou Enhua Pharmaceutical Co., Ltd. Highly Active Yeast, The Mc-DougallsKitchen, Englandd. Others are commercially available analytical reagents.

1.2 Animals NIH mice (certificate number: 01A018), body weight 17-21 g; SD rats (certificate number: 01A017), body weight 180-220 g. All were provided by the Guangdong Medical Experimental Animal Center.

1.3 Instruments GJ-8402 Hot Plate Pain Tester, Zhejiang Baishi Scientific Instrument Factory. 7550 spectrophotometer, Hewlett-Packard Shanghai Analytical Instrument Co., Ltd. Japanese Omron digital display thermometer.

2 Methods and results

2.1 Effects on artificial fever of fresh yeast Male SD rats, weighing 180-220g, were measured by rectal temperature, and 50 rats with rectal temperature between 36.6°C and 38.3°C were selected and randomly divided into 5 groups, 10 rats in each group; normal saline group , Liyan prescription low, medium and high dose groups (2.5, 5, 10g/kg), aspirin (0.2g/kg) group. The Liyan Prescription was administered continuously for 3 days, and on the third day, a dose of 2ml/100g body weight was used to subcutaneously inject 1.5% fresh yeast suspension into the neck and back of rats. The intragastric administration was started 5 hours after the injection of the yeast, and the rectal temperature was measured 1 hour after the administration, and then measured every 1 hour. Rats were always placed in a room with a room temperature of 22°C.

The results are shown in Table 1. Liyan Recipe has a significant antipyretic effect on rats with artificial fever caused by fresh yeast (P<0.001), and the effect can be maintained for at least 4 hours.

2.2 The effect on pain caused by the hot plate method Take 18-22g male mice, put one mouse on a metal hot plate at 55±0.5°C each time, and the time required for the mice to lick their hind feet from the time they are placed on the hot plate (s) is used as the pain threshold of the mouse. Those who lick the hind feet for less than 5 seconds or more than 30 seconds or jump are discarded. Qualified mice were randomly divided into 5 groups, 10 in each group, and their normal pain thresholds were repeatedly measured. The doses in Table 2 were administered continuously for 3 days, once a day. The pain threshold was measured at 60, 120, 180, and 240 minutes after the medicine, and if the pain threshold was 60 seconds, it was calculated as 60 seconds, so as not to affect the next observation due to scalding the animal's paw. Animals were kept in a room at 20°C throughout.

The results are shown in Table 2. The middle and high doses of Liyan Fang have a significant inhibitory effect on the pain induced by the hot plate method in mice, and the high dose group (10g/kg) has a significant analgesic effect 60 to 240 minutes after administration (P 0.01), The middle dose group (5g/kg) also had significant analgesic effect 60-180 minutes after administration (P 0.01).

2.3 Effects on increased permeability of the capillaries in the abdominal cavity of mice 50 mice weighing 18-22 g were randomly divided into 5 groups with 10 mice in each group. Intravenously inject 0.1ml of Evans blue solution with a concentration of 1g/100ml/mouse, and at the same time intraperitoneally inject 0.6% acetic acid solution 0.2ml/mouse, kill the mice after 20 minutes, cut the abdominal cavity, wash the abdominal cavity several times with 3ml distilled water, and draw About 3-4ml of peritoneal washings was centrifuged at 1000r/min for 5 minutes, and the absorbance value was measured at 590nm.

The results are shown in Table 3. The three doses of Liyan Prescription have obvious inhibitory effects on the increase of mouse peritoneal capillary permeability caused by H ⁺ , and inhibit inflammatory exudation. Compared with the normal saline group, there is a very significant effect. difference (P<0.01).

3 Discussion

Liyan Recipe has obvious antipyretic, analgesic and anti-inflammatory effects. For artificial fever caused by fresh yeast in rats, Liyan Formula can lower body temperature by up to 0.8°C. For the pain caused by hot plate method, Liyan Prescription can significantly increase the pain threshold, the highest pain threshold can be increased by 43.8%. Liyan Fang can also inhibit the increase of the permeability of the capillaries in the mouse peritoneal cavity caused by acetic acid, and the inhibition rate can reach 34.8%. The results of drug efficacy experiment are consistent with the clinical curative effect of Liyan Fang on acute and chronic pharyngitis.

Table 1, the effect of Liyinfang on artificial fever of fresh yeast (x±s, n=10) group dose(%) Rat body temperature (°C) -5 0 1 2 3 4h normal saline 20ml/kg 37.4±0.2 39.3±0.2 39.7±0.4 40.1±0.2 40.0±0.3 39.9±0.3 Liyan Recipe 2.5 37.8±0.2 39.3±0.4 39.5±0.4 39.7±0.3** 39.8±0.2 39.9±0.2 5 375±0.2 39.2±0.2 39.3±0.3* 39.3±0.3*** 39.6±0.3** 39.6±0.2** 10 37.5±0.1 39.2±0.2 39.0±0.7** 39.3±0.5*** 39.4±0.3*** 39.4±0.3*** Grass coral lozenges 0.2 37.4±0.2 39.0±0.2 37.6±0.2*** 37.5±0.3** 38.0±0.5*** 38.2±0.5***

Compared with normal saline group, *P 0.05, **P 0.01, ***P 0.001

Table 2 Effect of Liyan Prescription on pain induced by hot plate method in mice (x±s, n=10) group dose(%) Rat body temperature (°C) 0 60 120 180 240 normal saline 20ml/kg 14.1±3.8 14.5±4.3 13.8±3.8 13.8±3.2 13.3±3.0 Liyan Recipe 2.5 13.7±3.9 15.6±3.7 15.1±3.6 16.9±3.3* 14.4±4.4 5 14.0±2.6 18.4±2.7* 17.4±2.7* 18.3±3.7** 15.3±3.5 10 13.6±3.7 19.6±4.6** 19.6±5.5** 19.8±5.1** 18.12±3.7** Grass coral lozenges 2 13.8±2.4 18.4±4.0* 18.7±4.2** 18.6±4.0** 17.1±3.0**

Compared with normal saline group, *P 0.05, **P 0.01

Table 3 Effect of Liyan Recipe on Permeability of Peritoneal Capillaries in Mice (x±s, n=10) group dose OD590 Inhibition rate(%) normal saline 20ml/kg 0.310±0.072 Liyan Recipe 2 0.232±0.088* 25.16 4 0.216±0.094** 30.32 8 0.202±0.081** 34.84 Grass coral lozenges 2 0.215±0.086** 30.64

Compared with normal saline group, *P 0.05, **P 0.01

Claims (6)

1. a Chinese medicine preparation for the treatment of acute and chronic pharyngitis, which is prepared by the following proportioning by weight of Achyranthes Radix, Radix Glycyrrhizae and Radix Glycyrrhizae: Achyranthes 45-60, Gang Megan 70-85, Licorice 8-12. 2. according to a kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis according to claim 1, it is prepared by the proportioning of following parts by weight by Achyranthes Radix Achyranthes Radix, Radix Glycyrrhizae and Radix Glycyrrhizae: Soil achyranthes 50-55, Gang Megan 75-80, Licorice 8-12. 3. according to a kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis according to claim 1, it is prepared by the proportioning of following parts by weight by Achyranthes Radix Achyranthes Radix, Radix Glycyrrhizae and Radix Glycyrrhizae: Achyranthes 53, Gang Megan 77, Licorice 10. 4. according to a kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis according to claim 1-3, it can be oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray, pill or drop pill type. 5. a kind of preparation method of the Chinese medicine preparation for the treatment of acute and chronic pharyngitis of claim 1, it is made up of the following steps: A. Add 3-6 times the amount of water to decoct Achyranthes bidentata, Gangmeigen and licorice twice, the first time is 2-2.5 hours, and the second time is 1.5-2 hours; B. Filtrate, combine the filtrates, and concentrate; add 50-60% ethanol to soak for 10-15 hours, filter, recover ethanol, and add water to the required amount; C. Subpackaged into finished oral liquid. 6. a kind of preparation method of the Chinese medicine preparation for the treatment of acute and chronic pharyngitis of claim 1, it is made up of the following steps: A. Mix the soil Achyranthes bidentata, Gangmeigen and licorice after crude drug treatment, add 3-6 times the amount of water to boil, extract 2 times, the first time is 2-2.5 hours, and the second time is 1.5-2 hours; B. filter, combine secondary filtrate, concentrate; C. Add 50-60% ethanol to soak for 10-15 hours, filter, recover ethanol, concentrate the filtrate, and spray dry it into a fine powder; D. Add appropriate amount of starch and microcrystalline fiber to the fine powder, mix evenly, divide into capsules, and then the finished product is formed.