CN1229020C - Nicotine microcapsule suspoemulsion and preparation method thereof - Google Patents
Nicotine microcapsule suspoemulsion and preparation method thereof Download PDFInfo
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- CN1229020C CN1229020C CN 03139131 CN03139131A CN1229020C CN 1229020 C CN1229020 C CN 1229020C CN 03139131 CN03139131 CN 03139131 CN 03139131 A CN03139131 A CN 03139131A CN 1229020 C CN1229020 C CN 1229020C
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 37
- 229960002715 nicotine Drugs 0.000 title claims abstract description 37
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 239000003094 microcapsule Substances 0.000 title claims abstract description 25
- 239000004548 suspo-emulsion Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003292 glue Substances 0.000 claims abstract description 46
- 238000003756 stirring Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 235000013311 vegetables Nutrition 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 10
- 239000008158 vegetable oil Substances 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 239000012752 auxiliary agent Substances 0.000 claims abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 12
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 10
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 10
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 8
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical group [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 claims description 8
- 239000008096 xylene Substances 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- 229920000159 gelatin Polymers 0.000 claims description 7
- 239000008273 gelatin Substances 0.000 claims description 7
- 235000019322 gelatine Nutrition 0.000 claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 7
- 235000010413 sodium alginate Nutrition 0.000 claims description 7
- 229940005550 sodium alginate Drugs 0.000 claims description 7
- 239000000661 sodium alginate Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- 235000014102 seafood Nutrition 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical group C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 claims description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 5
- 235000012343 cottonseed oil Nutrition 0.000 claims description 5
- 239000002385 cottonseed oil Substances 0.000 claims description 5
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 claims description 4
- 241000206672 Gelidium Species 0.000 claims description 4
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical group C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims description 4
- 108010059642 isinglass Proteins 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229910052627 muscovite Inorganic materials 0.000 claims description 4
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 claims description 4
- 229960003656 ricinoleic acid Drugs 0.000 claims description 4
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 5
- 238000001914 filtration Methods 0.000 abstract description 4
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- QWUWMCYKGHVNAV-UHFFFAOYSA-N 1,2-dihydrostilbene Chemical group C=1C=CC=CC=1CCC1=CC=CC=C1 QWUWMCYKGHVNAV-UHFFFAOYSA-N 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 229920001938 Vegetable gum Polymers 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000003090 pesticide formulation Substances 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
(一)技术领域：(1) Technical field:
本发明涉及农药的剂型技术领域，具体地讲是一种烟碱微胶囊悬乳剂及其制备方法。The invention relates to the technical field of pesticide formulations, in particular to a nicotine microcapsule suspoemulsion and a preparation method thereof.
(二)背景技术：(two) background technology:
众所周知，烟碱是从烟草中直接提出的，具有高效、低毒、无残留的特点，适合无公害绿色食品施用，但烟碱本身见光分解，在阳光下半小时内挥发完。As we all know, nicotine is extracted directly from tobacco. It has the characteristics of high efficiency, low toxicity, and no residue. It is suitable for the application of pollution-free green food. However, nicotine itself is decomposed by light and volatilizes within half an hour in the sun.
(三)发明内容：(3) Contents of the invention:
本发明的目的旨在克服上述已有技术的不足，而提供一种烟碱微胶囊悬乳剂。The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, and provide a nicotine microcapsule suspoemulsion.
本发明的另一目的是提供烟碱微胶囊悬乳剂的制备方法。Another object of the present invention is to provide a preparation method of nicotine microcapsule suspoemulsion.
本发明主要解决了烟碱见光分解快的问题。The invention mainly solves the problem of fast decomposition of nicotine upon exposure to light.
本发明的烟碱微胶囊悬乳剂由于其囊皮完全由天然的高分子聚合物组成，可以在空气中完全裂解，对植物本身和环境无污染，可在蔬菜、瓜果等经济作物上大面积使用。The nicotine microcapsule suspoemulsion of the present invention can be completely cracked in the air because its capsule skin is completely composed of natural high molecular polymers, has no pollution to the plant itself and the environment, and can be used on a large area of economic crops such as vegetables, melons and fruits. use.
为了达到上述目的，本发明是这样实现的：烟碱微胶囊悬乳剂，其特征在于它是以烟碱为有效成份，并含有表面活性剂、植物油、助剂、溶剂、水，同时还含有海产品胶与动物胶和植物胶中的一种或两种的水解物的组合物；表面活性剂为三苯乙基酚聚氧乙烯醚、二苄基联苯酚聚氧乙烯醚，植物油为棉籽油、菜籽油、蓖麻油酸，助剂为十二烷基苯磺酸钙、苯乙基酚聚氧乙烯聚氧丙烯醚、蓖麻油环氧乙烷加成物，溶剂为二甲苯，动物胶为明胶，植物胶为淀粉胶，海产品胶为鱼胶、褐藻酸钠。In order to achieve the above object, the present invention is achieved as follows: nicotine microcapsule suspoemulsion, which is characterized in that it uses nicotine as an active ingredient, and contains surfactants, vegetable oils, additives, solvents, water, and seawater Composition of product gum and hydrolyzate of one or both of animal gum and vegetable gum; surfactant is tristyrylphenol polyoxyethylene ether, dibenzyl biphenol polyoxyethylene ether, and vegetable oil is cottonseed oil , rapeseed oil, ricinoleic acid, additives are calcium dodecylbenzenesulfonate, phenylethylphenol polyoxyethylene polyoxypropylene ether, castor oil ethylene oxide adduct, solvent is xylene, animal glue Gelatin, vegetable glue is starch glue, seafood glue is isinglass and sodium alginate.
本发明的烟碱微胶囊悬乳剂的制备方法，包括如下工艺步骤：The preparation method of the nicotine microcapsule suspoemulsion of the present invention comprises the following process steps:
a，囊核的制作，将油状液烟碱中，加入助剂、植物油、表面活性剂，再加入溶剂进行稀释，加热至60-80℃，同时不断搅拌，再加入一定量的水；助剂为十二烷基苯磺酸钙、苯乙基酚聚氧乙烯聚氧丙烯醚、蓖麻油环氧乙烷加成物，植物油为棉籽油、菜籽油、蓖麻油酸，表面活性剂为三苯乙基酚聚氧乙烯醚、二苄基联苯酚聚氧乙烯醚，溶剂为二甲苯；a, the production of the capsule core, adding additives, vegetable oil, and surfactant to the oily liquid nicotine, then adding a solvent to dilute, heating to 60-80°C, stirring continuously at the same time, and then adding a certain amount of water; additives Calcium dodecylbenzenesulfonate, phenylethylphenol polyoxyethylene polyoxypropylene ether, castor oil ethylene oxide adduct, vegetable oil is cottonseed oil, rapeseed oil, ricinoleic acid, surfactant is three Phenylphenol polyoxyethylene ether, dibenzyl biphenol polyoxyethylene ether, the solvent is xylene;
b，囊皮的制作，将海产品胶与动物胶和植物胶中的一种或两种胶分别先进行各类胶的水解，分别加热至60-80℃，过滤后混合，搅拌均匀即可；海产品胶为鱼胶、褐藻酸钠，动物胶为明胶，植物胶为淀粉胶；b. For the production of capsule skin, hydrolyze seafood glue, one or two kinds of glue from animal glue and vegetable glue, respectively, heat them to 60-80°C, filter and mix, and stir evenly. The seafood glue is isinglass and sodium alginate, the animal glue is gelatin, and the vegetable glue is starch glue;
c，微胶囊制剂，将步骤b的囊皮原料倒入步骤a的囊核的反应釜中，在200-600转/分的转速下混合搅拌，同时自然降温2小时后，进行包装。c, microcapsule preparation, pour the raw material of capsule skin in step b into the reaction kettle of capsule core in step a, mix and stir at a speed of 200-600 rpm, and pack after natural cooling for 2 hours.
本发明的烟碱微胶囊悬乳剂的制备方法，其所述的囊皮采用动物胶和植物胶时，其囊皮孔小且不均匀，达不到按要求规定的释放时间，因此还需加入发泡剂。In the preparation method of the nicotine microcapsule suspoemulsion of the present invention, when animal glue and vegetable glue are used for the capsule skin, the pores of the capsule skin are small and uneven, and the release time specified by the requirements cannot be reached, so it is necessary to add Foaming agent.
本发明的烟碱微胶囊悬乳剂是用有机大分子将农药有效体从外边包起来，得用大分子囊壁的晶格空隙缓慢的释放出来，避免其光解，从而极大的减少原药的用量，延长持效期，可人为地控制其持效期和释放速度；因烟碱见光分解快，因而为控制其药效时间，其微胶囊的粒径较大，一般控制在10-50微米。The nicotine microcapsule suspoemulsion of the present invention uses organic macromolecules to wrap the effective pesticide body from the outside, and releases it slowly through the lattice gap of the macromolecular capsule wall to avoid its photolysis, thereby greatly reducing the cost of the original drug. Dosage, prolonging the effect period, can artificially control its effect period and release speed; because nicotine sees light decomposition quickly, so in order to control its drug effect time, the particle size of its microcapsules is relatively large, generally controlled at 10-50 Micron.
本发明所述的一种烟碱微胶囊悬乳剂及其制备方法与已有技术相比，具有实质性特点和显著进步：1、烟碱微胶囊悬乳剂见光分解慢，从而提高其药效，同时延长药效时间，经试验得知，其原药减少30-50％，防治效果提高10-20％，持效期延长3-10倍；2、烟碱微胶囊悬乳剂其囊皮完全由天然聚合物组成，可完全生物降解，因而无残留，可在无公害绿色经济作物上广泛使用。Compared with the prior art, a kind of nicotine microcapsule suspoemulsion of the present invention and its preparation method have substantive characteristics and remarkable progress: 1. The nicotine microcapsule suspoemulsion decomposes slowly when exposed to light, thereby improving its drug efficacy , at the same time prolong the drug effect time, it is known through the test that its original drug is reduced by 30-50%, the control effect is improved by 10-20%, and the duration of effect is extended by 3-10 times; Composed of natural polymers, it is completely biodegradable, so there is no residue, and can be widely used in pollution-free green economic crops.
(四)具体实施方式：(4) Specific implementation methods:
为了更好地理解与实施，下面结合实施例详细说明本发明一种烟碱微胶囊悬乳剂及其制备方法。For better understanding and implementation, a nicotine microcapsule suspoemulsion of the present invention and its preparation method will be described in detail below in conjunction with examples.
实施例1，将2.8g油状液烟碱、加入0.5g十二烷基苯磺酸钙、0.5g苯乙基酚聚氧乙烯聚氧丙烯醚、3g蓖麻油、4g三苯乙基酚聚氧乙烯醚、6g二甲苯，加热至70℃，同时不断进行搅拌，再加入16g水，备用；将8g明胶、8g褐藻酸钠分别加入92g水进行水解，分别加热至70℃，取上述水解后的胶液各25g进行过滤，过滤后混合，并搅拌均匀，将搅拌均匀的胶液加入前面制成的备用液中，在400转/分的转速下混合搅拌，同时自然降温2小时后，即得烟碱微胶囊悬乳剂。Example 1, add 2.8g oily liquid nicotine, add 0.5g calcium dodecylbenzenesulfonate, 0.5g styrylphenol polyoxyethylene polyoxypropylene ether, 3g castor oil, 4g tristyrylphenol polyoxygenate Vinyl ether and 6g xylene were heated to 70°C while stirring continuously, and then 16g of water was added for later use; 8g of gelatin and 8g of sodium alginate were added to 92g of water for hydrolysis, respectively, heated to 70°C, and the above-mentioned hydrolyzed Each 25g of the glue solution is filtered, mixed after filtering, and stirred evenly, and the well-stirred glue solution is added to the standby liquid prepared above, mixed and stirred at a speed of 400 rpm, and cooled naturally for 2 hours at the same time to obtain Nicotine microcapsule suspoemulsion.
上述实施例的烟碱微胶囊悬乳剂与5％的烟碱乳油在防治莱青虫药效持效期对比表如表1。Table 1 shows the comparison of the duration of efficacy of the nicotine microcapsule suspoemulsion and 5% nicotine emulsifiable concentrate in the control of Laibidia spp.
表1Table 1
实施例2，将5g油状液烟碱、加入0.6g十二烷基苯磺酸钙、0.6g蓖麻油环氧乙烷加成物、4g棉籽油、4.5g二苄基联苯酚聚氧乙烯醚、7g二甲苯，加热至60℃，同时不断进行搅拌，再加入18g水，备用；将8g淀粉胶、8g褐藻酸钠分别加入92g水进行水解，分别加热至60℃，取上述水解后的胶液各28g进行过滤，过滤后混合，并搅拌均匀，将搅拌均匀的胶液加入前面制成的备用液中，在500转/分的转速下混合搅拌，同时自然降温2小时后，即得烟碱微胶囊悬乳剂。Example 2, add 5g oily liquid nicotine, add 0.6g calcium dodecylbenzenesulfonate, 0.6g castor oil ethylene oxide adduct, 4g cottonseed oil, 4.5g dibenzyl biphenol polyoxyethylene ether , 7g of xylene, heated to 60°C while stirring continuously, then added 18g of water, and set aside; respectively added 8g of starch glue and 8g of sodium alginate to 92g of water for hydrolysis, heated to 60°C respectively, and took the above-mentioned hydrolyzed glue Filter each 28g of liquid, mix after filtering, and stir evenly, add the uniformly stirred glue liquid into the spare liquid prepared above, mix and stir at a speed of 500 rpm, and cool down naturally for 2 hours at the same time to obtain smoke Alkaline microcapsule suspoemulsion.
实施例3，将2g油状液烟碱、加入0.2g十二烷基苯磺酸钙、0.2g苯乙基酚聚氧乙烯聚氧丙烯醚、2g菜籽油、3g三苯乙基酚聚氧乙烯醚、5g二甲苯，加热至50℃，同时不断进行搅拌，再加入14g水，备用；将7.5g明胶、7.5g淀粉胶分别加入92g水进行水解，分别加热至50℃，取上述水解后的胶液各15g进行过滤，过滤后混合，并搅拌均匀，加入1g发泡剂，将搅拌均匀的胶液加入前面制成的备用液中，在200转/分的转速下混合搅拌，同时自然降温2小时后，即得烟碱微胶囊悬乳剂。Example 3, add 2g oily liquid nicotine, add 0.2g calcium dodecylbenzenesulfonate, 0.2g styrylphenol polyoxyethylene polyoxypropylene ether, 2g rapeseed oil, 3g tristyrylphenol polyoxygenate Vinyl ether and 5g xylene were heated to 50°C while stirring continuously, and then 14g of water was added for later use; 7.5g of gelatin and 7.5g of starch glue were respectively added to 92g of water for hydrolysis, respectively heated to 50°C, and the above hydrolyzed Each 15g of the glue solution is filtered, mixed after filtering, and stirred evenly, and 1g of foaming agent is added, and the well-stirred glue solution is added to the standby liquid prepared above, mixed and stirred at a speed of 200 rpm, and naturally After cooling down for 2 hours, the nicotine microcapsule suspoemulsion was obtained.
实施例4，将10g油状液烟碱、加入1g十二烷基苯磺酸钙、1g苯乙基酚聚氧乙烯聚氧丙烯醚、5g蓖麻油、5g三苯乙基酚聚氧乙烯醚、10g二甲苯，加热至80℃，同时不断进行搅拌，再加入20g水，备用；将8g明胶、8g褐藻酸钠分别加入92g水进行水解，分别加热至60℃，取上述水解后的胶液各30g进行过滤，过滤后混合，并搅拌均匀，将搅拌均匀的胶液加入前面制成的备用液中，在600转/分的转速下混合搅拌，同时自然降温2小时后，加入防冻液、染料后进行包装，即得烟碱微胶囊悬乳剂。Example 4, add 10g oily liquid nicotine, add 1g calcium dodecylbenzenesulfonate, 1g styrylphenol polyoxyethylene polyoxypropylene ether, 5g castor oil, 5g tristyrylphenol polyoxyethylene ether, Heat 10g of xylene to 80°C while stirring continuously, then add 20g of water and set aside; add 8g of gelatin and 8g of sodium alginate to 92g of water for hydrolysis, heat to 60°C respectively, and take the above hydrolyzed glue solution 30g to filter, filter and mix, and stir evenly, add the well-stirred glue solution to the spare solution prepared above, mix and stir at a speed of 600 rpm, and cool down naturally for 2 hours, then add antifreeze and dye After packing, the nicotine microcapsule suspoemulsion is obtained.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139131 CN1229020C (en) | 2003-08-16 | 2003-08-16 | Nicotine microcapsule suspoemulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139131 CN1229020C (en) | 2003-08-16 | 2003-08-16 | Nicotine microcapsule suspoemulsion and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1513311A CN1513311A (en) | 2004-07-21 |
| CN1229020C true CN1229020C (en) | 2005-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03139131 Expired - Fee Related CN1229020C (en) | 2003-08-16 | 2003-08-16 | Nicotine microcapsule suspoemulsion and preparation method thereof |
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| CN (1) | CN1229020C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007069461A1 (en) * | 2005-12-14 | 2007-06-21 | Sumitomo Chemical Company, Limited | Microencapsulated pesticide |
| CN103651588B (en) * | 2013-09-10 | 2015-11-11 | 北京联合大学生物化学工程学院 | A kind of preparation method of the encapsulate pesticides for killing aphid |
| CN110250174B (en) * | 2018-03-12 | 2022-08-19 | 侨昌现代农业有限公司 | Oil-containing dry suspending agent formulation and processing technology thereof |
| CN109757475A (en) * | 2019-03-01 | 2019-05-17 | 杨卫东 | A kind of microcapsule formulation and preparation method thereof coating solid pesticide raw medicine |
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2003
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| CN1513311A (en) | 2004-07-21 |
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Owner name: ZHONG WEIDE Free format text: FORMER OWNER: ZHANG TIANLIANG Effective date: 20061013 |
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Effective date of registration: 20061013 Address after: 100071, Fengtai District Science City, Beijing, No. 10 Spark Road B-107 Beijing Tianshan dark horse Biotechnology Co., Ltd. Patentee after: Zhong Weide Address before: 265601 north ditch, Shandong, Penglai, Beijing, Shandong, Beijing biological pharmaceutical, Limited by Share Ltd Patentee before: Zhang Tianliang |
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Assignee: Beijing Tianshan dark horse Biotechnology Co., Ltd. Assignor: Zhong Weide Contract fulfillment period: 2007.6.6 to 2012.6.5 contract change Contract record no.: 2009990000430 Denomination of invention: Suspension emulsion of nicotine microcapsule, and its prepn. method Granted publication date: 20051130 License type: Exclusive license Record date: 2009.5.6 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.6.6 TO 2012.6.5; CHANGE OF CONTRACT Name of requester: BEIJING TIANSHAN HEIMA BIOTECHNOLOGY CO., LTD. Effective date: 20090506 |
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