CN1216983C - Medicinal wine compsn and its prepn. method - Google Patents
Medicinal wine compsn and its prepn. method Download PDFInfo
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- CN1216983C CN1216983C CN 03149773 CN03149773A CN1216983C CN 1216983 C CN1216983 C CN 1216983C CN 03149773 CN03149773 CN 03149773 CN 03149773 A CN03149773 A CN 03149773A CN 1216983 C CN1216983 C CN 1216983C
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The present invention relates to a medicinal wine composition and a manufacture method thereof. The preparation raw materials of active components contained in the medicinal wine composition comprise total recipes for nourishing and activating blood, total recipes for nourishing yin, total recipes for supplementing Qi, kidney supplementing and yang strengthening drugs, Qi traveling drugs, bitter cold and heat clearing drugs, wind expelling, vessel permeating, muscle relaxing and pain alleviating drugs and grain wine. The medicinal wine composition of the present invention has the obvious effects in treating weak yang and strong cold, Qi and blood deficiency, Qi stagnation of spleens and stomachs, weak bodies with multiple diseases, attenuated and weak bodies, soft muscles, lumbago, gonalgia, chest and belly tumescence, diarrhea with accumulated lumps, man spermatorrhea, impotence, premature ejaculation and woman menoxenia.
Description
[invention field]
The present invention relates to a kind of health promoting beverage and preparation method thereof, more specifically, the present invention relates to a kind of medicated wine composition and preparation method thereof.
[background technology]
Medicinal liquor historical of long standing and well established, from Qin Han so far people constantly studied various medicinal liquor.Wine and Chinese medicinal materials compatibility can strengthen the efficacy of a drug, can disease preventing and treating, can be used for assisting therapy after being ill again." in Chinese pharmacopoeia and some reports, propose liquor with certain ethanol content as extracting solution, soak the prepared slices of Chinese crude drugs under certain conditions, can farthest utilize the effective constituent in the Chinese medicinal materials, also improve the recovery rate of medicinal liquor, thereby obtained high-quality medicinal liquor.The application for a patent for invention of relevant medicinal liquor is a lot, for example ZL98110384.7 discloses a kind of production method of healthy medicated wine, it is basic wine that this method is selected grain wine for use, in this basic wine, soak 16 kinds of Chinese medicinal materialss such as Radix Asparagi, Radix Rehmanniae, red ginseng, and seal up for safekeeping more than four days, just obtain finished product medicinal liquor after removing residue, this medicinal liquor has invigorate vital energy and yang, effects such as essence, blood circulation and promoting silt are added in enriching yin; CN1200281A discloses with tens of kinds of Chinese medicinal materialss such as leopard bone, deer whip, hippocampus and has soaked 10-20 day through grain wine, obtains a kind of medicinal liquor after the filtration, and this medicinal liquor has enriching yin and nourishing kidney, breaks effects such as fiber crops are promoted blood circulation, beneficial able-bodied sun, spleen-benefiting mind-tranquilizing.But still there are some defectives in these medicinal liquor applications for a patent for invention.The physiological activity of people's health is complicated, and different colonies is the different characteristics of each tool again, and existing these medicinal liquor also are difficult to satisfy these requirements.Therefore also need to develop new medicinal liquor, to satisfy the various demands of people.
[summary of the invention]
[problem that will solve]
The purpose of this invention is to provide a kind of medicated wine composition (being referred to as refreshing rich board Wan Defu wine usually), this medicated wine composition has the effect of a surname's promoting blood circulation.
Another object of the present invention is the preparation method of described medicated wine composition.
[summary of the invention]
The inventor through concentrating on studies for many years, has invented a kind of medicated wine composition and preparation method thereof now on the basis of summing up a large amount of medicinal liquor prescriptions of forefathers.
The medicinal liquor prescription should be prepared according to " monarch " traditional Chinese medical science general principle.Call in " interior warp, sink greatly " book, the medicine meaning monarch of main disease, assistant monarch's medicine meaning minister is answered the medicine of minister to call and is made.The present invention is according to this traditional Chinese medical science general principle, serves as the prescription that master side basis proposes with gas, blood, yin, yang, and this prescription is generous, the compound of the traditional Chinese medical science, from multi-angle system side, with the intricate property that adapts to illness and many characteristics of human body self.
Medicated wine composition of the present invention is characterized in that the preparation raw material of the activeconstituents that it is contained comprises that the nourshing blood and promoting blood circulation of being made up of cultivated land, Radix Angelicae Sinensis, Ligusticum wallichii and the root of herbaceous peony is always square, is referred to as SIWU TANG; Always square by the enriching yin that cultivated land, Chinese yam, Fructus Corni, Poria cocos, rhizoma alismatis and the root bark of tree peony are formed, be referred to as LIUWEI DIHUANG TANG; Always square by the tonifying Qi that Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome and Radix Glycyrrhizae are formed, be referred to as decoction of four noble drugs, and grain wine.
In a preferred embodiment of the invention, medicated wine composition of the present invention also contains the kidney-nourishing yang-strengthening medicine that is selected from South Dodder Seed Chinese Dodder Seed, Herba Epimedii, shizandra berry, genseng, glossy ganoderma, the root of straight ladybell, Radix Morindae Officinalis, Fructus Cnidii, Herba Cistanches, leek seed, POGUZHI, Ootheca Mantidis, oyster, walnut kernel, donkey-hide gelatin, radix polygonati officinalis, Testis et penis callorhini, Spongilla, wolfberry fruit, hippocampus, sea otter, deer whip and/or wide dog whip, and these medical instruments have the effect of warming and recuperating the kidney-YANG.
In another the preferred embodiments of the invention, medicated wine composition of the present invention also contains the qi-activating drug that is selected from Radix Aucklandiae (Radix Vladimiriae), star anise, agalloch eaglewood, cloves, santal, nutmeg, wide skin and/or fructus amomi, these medical instruments have unobstructed mechanism of qi, prevent to nourish the high effect that stagnates of stopping up, and also have the effect of the absorption that helps medicine on the other hand.
In another the preferred embodiments of the invention, medicated wine composition of the present invention also contains the clearing up internal heat by using drugs of bitter in taste and cold in nature medicine that is selected from Medulla Junci, cape jasmine and/or chrysanthemum, these medicines can prevent that the temperature of Yang invigorating medicine is dry, can make clear refreshing quiet, calm, the safe and sound effect of the heart again with the reason that gets YIN and YANG promoting each other.
In another the preferred embodiments of the invention, medicated wine composition of the present invention also contains the network Shujin anodyne that dispels the wind that is selected from Stem of Orientoine, Kadsura Pepper Stem, turmeric, pawpaw, Root of Sixpetal Clematis, levisticum, the root of Dahurain angelica, Radix Aconiti Preparata, MALANZI, safflower and/or Radix Aconiti Kusnezoffii Preparata, these medical instruments have the effect of clearing damp Shujin, dispelling wind and relieving pain, the network of invigorating blood circulation, qi and blood is abundant, on the vigorous basis of healthy tendency, the drum heresy is gone out, and the blood sector-style is gone out, the effect that the wet network peace of dispelling, the logical pain of warp are ended.
In medicated wine composition of the present invention, the total side of described nourshing blood and promoting blood circulation is in weight part 74-94 weight part; The total side 151-189 of enriching yin weight part; The total side 320-388 of tonifying Qi weight part.
In a kind of the preferred embodiments of the invention, said composition also contains one or more kidney-nourishing yang-strengthening medicines that is selected from South Dodder Seed Chinese Dodder Seed, Herba Epimedii, shizandra berry, genseng, glossy ganoderma, the root of straight ladybell, Radix Morindae Officinalis, Fructus Cnidii, Herba Cistanches, leek seed, POGUZHI, Ootheca Mantidis, oyster, walnut kernel, donkey-hide gelatin, radix polygonati officinalis, Testis et penis callorhini, Spongilla, wolfberry fruit, hippocampus, sea otter, deer whip or wide dog whip, and its consumption is the 862-1073 weight part in weight part.More preferably, described kidney-nourishing yang-strengthening medicine is the 880-1050 weight part.
Preferably, said composition also contains one or more qi-activating drugs that is selected from Radix Aucklandiae (Radix Vladimiriae), star anise, agalloch eaglewood, cloves, santal, nutmeg, wide skin and/or fructus amomi, and its consumption is in weight part 94-121 weight part.Preferably, described qi-activating drug is the 100-113 weight part.
Preferably, said composition also contains one or more clearing up internal heat by using drugs of bitter in taste and cold in nature medicines that is selected from Medulla Junci, cape jasmine or chrysanthemum, and its consumption is in weight part 44-58 weight part.Preferably, described clearing up internal heat by using drugs of bitter in taste and cold in nature medicine is the 48-55 weight part.
Preferably, said composition also contains one or more network Shujin anodyne that dispels the wind that is selected from Stem of Orientoine, Kadsura Pepper Stem, turmeric, pawpaw, Root of Sixpetal Clematis, levisticum, the root of Dahurain angelica, Radix Aconiti Preparata, MALANZI, safflower or Radix Aconiti Kusnezoffii Preparata, and its consumption is in weight part 169-217 weight part.Preferably, the described network Shujin anodyne that dispels the wind is the 180-206 weight part.
In medicated wine composition of the present invention, the total side of the nourshing blood and promoting blood circulation of said composition is by forming in weight part cultivated land 27-33 weight part, Radix Angelicae Sinensis 21-27 weight part, Ligusticum wallichii 10-14 weight part and root of herbaceous peony 16-20 weight part.
The total side of the enriching yin of said composition is by forming in weight part cultivated land 27-33 weight part, Chinese yam 54-66 weight part, Fructus Corni 10-14 weight part, Poria cocos 10-14 weight part, rhizoma alismatis 5-7 weight part and root bark of tree peony 45-55 weight part.
The total side of the tonifying Qi of said composition is by forming in weight part Radix Codonopsis 204-244 weight part, Poria cocos 10-14 weight part, bighead atractylodes rhizome 16-20 weight part and Radix Glycyrrhizae 90-110 weight part.
More preferably, the preparation raw material of the contained activeconstituents of medicated wine composition of the present invention is the total side of nourshing blood and promoting blood circulation by weight 84 weight parts, the total side of enriching yin 170 weight parts, the total side of tonifying Qi 354 weight parts, kidney-nourishing yang-strengthening medicine 967 weight parts, qi-activating drug 107 weight parts, clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 51 weight parts, network Shujin anodyne 195 weight parts dispel the wind.
Restriction that the grain wine that the present invention uses has nothing special can be selected from various grain wine, Kaoliang spirit etc. for example, and wherein these wine should be selected 38-65 ° grain wine for use, and preferably, these wine should be selected 45-60 ° grain wine for use.The consumption those skilled in the art of these wine generally can determine according to concrete applicable cases, normally per 100 weight part Chinese medicinal materials 800-1400 weight parts; Preferably, the consumption of these wine is the 1000-1300 weight part.
The invention still further relates to a kind of preparation method of this medicated wine composition.
The preparation method of this medicated wine composition comprises the steps:
(a) select above-mentioned Chinese medicinal materials raw material for use; Above-mentioned Chinese medicinal materials is clean, dry, pulverizing, Chinese medicinal materials raw material powder particle size are crucial especially, are crushed to usually more than 80 orders, and preferably, the 80-120 order takes by weighing the Chinese medicinal materials powder according to following dosage then by weight: the total side 74-94 of nourshing blood and promoting blood circulation part; The total side 151-189 of enriching yin part; The total side 320-388 of tonifying Qi part; Kidney-nourishing yang-strengthening medicine 862-1073 part; Qi-activating drug 94-121 part; Clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 44-58 part; The network Shujin anodyne 169-217 part of dispeling the wind;
Wherein: the total side of nourshing blood and promoting blood circulation is by forming in weight part cultivated land 27-33 part, Radix Angelicae Sinensis 21-27 part, Ligusticum wallichii 10-14 part and root of herbaceous peony 16-20 part;
The total side of enriching yin is by forming in weight part cultivated land 27-33 part, Chinese yam 54-66 part, Fructus Corni 10-14 part, Poria cocos 10-14 part, rhizoma alismatis 5-7 part and root bark of tree peony 45-55 part;
The total side of tonifying Qi is by forming with weight part Radix Codonopsis 204-244 part, Poria cocos 10-14 part, bighead atractylodes rhizome 16-20 part and Radix Glycyrrhizae 90-110 part;
(b) above-mentioned Chinese medicinal materials fine powder adopts in the art usually the high pressure steam sterilization technology to sterilize again;
(c) through the liquor 13000-28000 part immersion by weight of the Chinese medicinal materials powder of sterilization, at room temperature soaked 20-30 days, often stir therebetween;
(d) elimination residue carries out blending of wine more according to actual needs, then subzero 8 ℃ freezing 72 hours, refilter three times, obtain medicated wine composition of the present invention like this.
Filtering purpose is to remove various suspended solids that exist in the medicinal liquor etc., so those skilled in the art can select different filtration mediums according to practical situation, for example can be selected from diatomite machine, board and frame machine, Micro hole machine etc.
[beneficial effect]
Medicated wine composition of the present invention have treatment sun consider cold Sheng, insufficiency of vital energy and blood, the taste stagnation of the circulation of vital energy, weak and sickly, that health is weak, muscles and bones is withered is soft, the positive effect of lumbocrural pain, distension and fullness of the chest and abdomen, diarrhea mass in the abdomen, man's seminal emission, impotence and premature ejaculation, menoxenia.
[embodiment]
Be used for further describing the present invention with the test example by the following examples.
Embodiment 1
Take by weighing cultivated land 60 grams, Radix Angelicae Sinensis 24 grams, Ligusticum wallichii 12 grams, the root of herbaceous peony 18 grams; Chinese yam 60 grams, Fructus Corni 12 grams, Poria cocos 24 grams, rhizoma alismatis 6 grams, the root bark of tree peony 50 grams; Radix Codonopsis 224 grams, the bighead atractylodes rhizome 18 grams, Radix Glycyrrhizae 100 grams, South Dodder Seed Chinese Dodder Seed 12 grams, Herba Epimedii 12 grams, shizandra berry 15 grams, genseng 150 grams, glossy ganoderma 30 grams, the root of straight ladybell 6 grams, Radix Morindae Officinalis 12 grams, Fructus Cnidii 12 grams, Herba Cistanches 12 grams, leek seed 20 grams, POGUZHI 9 grams, Ootheca Mantidis 6 grams, oyster 6 grams, walnut kernel 15 grams, donkey-hide gelatin 6 grams, radix polygonati officinalis 20 grams, Testis et penis callorhini 100 grams, Spongilla 6 grams, wolfberry fruit 300 grams, hippocampus 15 grams, sea otter 3 grams, deer whip 100 grams, wide dog whip 100 grams, Radix Aucklandiae (Radix Vladimiriae) 9 grams, star anise 12 grams, agalloch eaglewood 3.6 grams, cloves 9 grams, santal 12 grams, nutmeg 6, wide skin 50 grams, fructus amomi 6 grams, Medulla Junci 12 grams, cape jasmine 15 grams, chrysanthemum 24 grams, Stem of Orientoine 12 grams, Kadsura Pepper Stem 12 grams, turmeric 74 grams, pawpaw 12 grams, Root of Sixpetal Clematis 12 grams, levisticum 6 grams, the root of Dahurain angelica 18 grams, Radix Aconiti Preparata 16 grams, MALANZI 3 grams, safflower 24 grams, Radix Aconiti Kusnezoffii Preparata 6 grams and 17000 gram Sorghum vulgare Pers. Wines are raw material.
Above-mentioned selected Chinese medicinal materials carries out strictness screening, removes mouldy septic medicinal material, removes impurity, washes then, dries, again with these pulverizing medicinal materials to 100 purpose fine powders, takes by weighing the Chinese medicinal materials powder according to consumption noted earlier then;
With the Chinese medicinal materials fine powder mixing of above-mentioned weighing, autoclaving is 20 minutes again;
Chinese medicinal materials powder through sterilization is spent the jowar soaking in Chinese liquor with 60, at room temperature soaks 25 days, every two hours stirs once therebetween;
After soaking end, the elimination dregs of a decoction are blent according to the practical use needs again, the wine of blending after filtering, descended freezing 72 hours at subzero 8 ℃ again, adopt diatomite machine, board and frame machine, Micro hole machine to filter in succession again three times, obtain medicated wine composition of the present invention like this.
Embodiment 2
Take by weighing cultivated land 56 grams, Radix Angelicae Sinensis 22 grams, Ligusticum wallichii 11 grams, the root of herbaceous peony 16 grams; Chinese yam 56 grams, Fructus Corni 11 grams, Poria cocos 21 grams, rhizoma alismatis 5 grams, the root bark of tree peony 46 grams; Radix Codonopsis 210 grams, the bighead atractylodes rhizome 16 grams, Radix Glycyrrhizae 90 grams, South Dodder Seed Chinese Dodder Seed 10 grams, Herba Epimedii 10 grams, shizandra berry 15 grams, glossy ganoderma 30 grams, genseng 150 grams, the root of straight ladybell 5 grams, Radix Morindae Officinalis 10 grams, Fructus Cnidii 10 grams, Herba Cistanches 10 grams, leek seed 18 grams, POGUZHI 8 grams, Ootheca Mantidis 5 grams, oyster 5 grams, walnut kernel 13 grams, donkey-hide gelatin 5 grams, radix polygonati officinalis 18 grams, Testis et penis callorhini 90 grams, Spongilla 5 grams, wolfberry fruit 270 grams, hippocampus 13 grams, sea otter 2 grams, deer whip 90 grams, wide dog whip 90 grams, Radix Aucklandiae (Radix Vladimiriae) 8 grams, star anise 10 grams, agalloch eaglewood 3.0 grams, cloves 8 grams, santal 10 grams, nutmeg 5, wide skin 45 grams, fructus amomi 6 grams, Medulla Junci 10 grams, cape jasmine 13 grams, chrysanthemum 21 grams, Stem of Orientoine 10 grams, Kadsura Pepper Stem 10 grams, turmeric 66 grams, pawpaw 10 grams, Root of Sixpetal Clematis 10 grams, levisticum 5 grams, the root of Dahurain angelica 16 grams, Radix Aconiti Preparata 14 grams, MALANZI 2 grams, safflower 21 grams, Radix Aconiti Kusnezoffii Preparata 5 grams and 18700 gram Kaoliang spirits are raw material.
Above-mentioned selected Chinese medicinal materials carries out strictness screening, removes mouldy septic medicinal material, removes impurity, washes then, dries, again with these pulverizing medicinal materials to 100 purpose fine powders, takes by weighing the Chinese medicinal materials powder according to consumption noted earlier then;
With the Chinese medicinal materials fine powder mixing of above-mentioned weighing, autoclaving is 20 minutes again;
Chinese medicinal materials powder through sterilization is spent the jowar soaking in Chinese liquor with 60, at room temperature soaks 25 days, every two hours stirs once therebetween;
After soaking end, the elimination dregs of a decoction are blent according to the practical use needs again, the wine of blending after filtering, descended freezing 72 hours at subzero 8 ℃ again, adopt diatomite machine, board and frame machine, Micro hole machine to filter in succession again three times, obtain medicated wine composition of the present invention like this.
Embodiment 3
Take by weighing cultivated land 66 grams, Radix Angelicae Sinensis 27 grams, Ligusticum wallichii 14 grams, the root of herbaceous peony 20 grams; Chinese yam 66 grams, Fructus Corni 14 grams, Poria cocos 34 grams, rhizoma alismatis 7 grams, the root bark of tree peony 55 grams; Radix Codonopsis 244 grams, the bighead atractylodes rhizome 20 grams, Radix Glycyrrhizae 110 grams, South Dodder Seed Chinese Dodder Seed 14 grams, Herba Epimedii 14 grams, shizandra berry 15 grams, genseng 150 grams, glossy ganoderma 30 grams, the root of straight ladybell 7 grams, Radix Morindae Officinalis 14 grams, Fructus Cnidii 14 grams, Herba Cistanches 14 grams, leek seed 22 grams, POGUZHI 11 grams, Ootheca Mantidis 7 grams, oyster 7 grams, walnut kernel 17 grams, donkey-hide gelatin 7 grams, radix polygonati officinalis 22 grams, Testis et penis callorhini 110 grams, Spongilla 7 grams, wolfberry fruit 330 grams, hippocampus 17 grams, sea otter 4 grams, deer whip 110 grams, wide dog whip 110 grams, Radix Aucklandiae (Radix Vladimiriae) 10 grams, star anise 14 grams, agalloch eaglewood 4 grams, cloves 10 grams, santal 14 grams, nutmeg 7, wide skin 55 grams, fructus amomi 7 grams, Medulla Junci 14 grams, cape jasmine 17 grams, chrysanthemum 27 grams, Stem of Orientoine 14 grams, Kadsura Pepper Stem 14 grams, turmeric 78 grams, pawpaw 14 grams, Root of Sixpetal Clematis 14 grams, levisticum 7 grams, the root of Dahurain angelica 20 grams, Radix Aconiti Preparata 18 grams, MALANZI 4 grams, safflower 27 grams, Radix Aconiti Kusnezoffii Preparata 7 grams and 25000 gram Sorghum vulgare Pers. Wines are raw material.
Above-mentioned selected Chinese medicinal materials carries out strictness screening, removes mouldy septic medicinal material, removes impurity, washes then, dries, again with these pulverizing medicinal materials to 100 purpose fine powders, takes by weighing the Chinese medicinal materials powder according to consumption noted earlier then;
With the Chinese medicinal materials fine powder mixing of above-mentioned weighing, autoclaving is 20 minutes again;
Chinese medicinal materials powder through sterilization soaks with 60 degree sorghum liquors, at room temperature soaks 25 days, every two hours stirs once therebetween;
After soaking end, the elimination dregs of a decoction are blent according to the practical use needs again, the wine of blending after filtering, descended freezing 72 hours at subzero 8 ℃ again, adopt diatomite machine, board and frame machine, Micro hole machine to filter in succession again three times, obtain medicated wine composition of the present invention like this.
Pharmacological test example 1
The refreshing rich board Wan Defu wine toxicology test of the present invention
Material and method:
Sample: provided by the inventor, the human body recommended amounts is everyone 50-100 every day milliliter, and concentrated 8 times of conducts are tried thing and are for experiment.
Experimental animal: cleaning level Kunming mouse (certification of fitness: the moving word of doctor 01-3001 number), provide by medical experiment zooscopy institute of Chinese Academy of Medical Sciences laboratory animal breeding field.
Acute toxicity test in mice: select 20 of body weight 18-22 gram mouse, male and female half and half, being tried the agent amount is 20 gram/k gram bw, irritates stomach and gives laboratory animal, observes record animal poisoning manifestations and death condition 14 days.
The mouse polychromatic erythrocytes micronucleus test: select 50 of body weight 25-30g mouse, be divided into 5 groups at random, 10 every group, male and female half and half.Tried in 3 experimental group that the agent amount is respectively 2.5,5.0,10.0g/kgbw, other establishes distilled water negative control group and endoxan positive controls (40mg/kgbw).Irritate stomach and tried thing, totally 2 times, 24 hours at interval, last was tried behind the thing to put to death in 6 hours animal, conventional film-making with giving.1000 polychromatic erythrocytes of every animal microscopy, record micronucleated cell number calculates micronuclear rates (representing with permillage).
Mouse sperm deformity test: select 25 of body weight 25-30g male mices, divide 5 groups at random.Every group 5.Tried in 3 experimental group that the agent amount is respectively 2.5,5.0,10.0g/kgbw, other establishes distilled water negative control group and endoxan positive controls (40mg/kgbw).Irritate stomach and tried thing, continuous 5 days, irritate first behind the stomach and to put to death animal, conventional film-making on the 35th day.The sperm of 1000 structural integrities of every animal counting, record distortion type and quantity are calculated rate of teratosperm (representing with percentage).
Mouse testis chromosomal aberration test: select 25 of body weight 25-30g male mices, divide 5 groups at random, 5 every group.Tried in 3 experimental group that the agent amount is respectively 2.5,5.0,10.0g/kgbw, other establishes distilled water negative control group and endoxan positive controls (40mg/kgbw). and irritate stomach and tried thing, continuous 5 days, irritate first behind the stomach and to put to death animal, conventional film-making on the 13rd day.100 metacinesis phases of every animal microscopy, record distortion type and quantity are calculated chromosome aberrations rate (representing with percentage).
The result
1, acute toxicity test: after the filling stomach was tried thing, the mouse of two kinds of sexes there is no obvious toxicity symptom, and animal does not have death (seeing Table 1) in 14 days.Therefore think this tried thing to the acute toxicity LD50 of two kinds of sex mouse all greater than 20g/kgbw.According to acute toxicity grading criteria, this sample belongs to non-toxic substance.
Table 1. acute toxicity test in mice result
| Animal varieties | Sex | Approach | LD50(g/kg·bw) |
| The mouse mouse | Male female | The per os per os | ＞20 ＞20 |
2, mouse polychromatic erythrocytes micronucleus test: by table 2 as seen, utmost point significant difference (P＜0.01) is arranged between negative control group mouse bone marrow cells micronuclear rates and the positive controls, the animal sensitivity is described, test is reliable.The difference (P＞0.05) of being tried that there are no significant between each dosage group of thing and the negative control group illustrates that this sample does not have the effect of the mouse polychromatic erythrocytes of causing micronucleus.
Table 2 mouse polychromatic erythrocytes micronucleus test result
| Sex | Dosage (g/kgbw) | Number of animals | Check cell count | The micronucleus number | Micronuclear rates (‰) |
| Male | 2.5 5.0 10.0 negative control group positive controls | 5 5 5 5 5 | 5×1000 5×1000 5×1000 5×1000 5×1000 | 11 10 10 9 146 | 2.2 2.0 2.0 1.8 29.2 ** |
| Female | 2.5 5.0 10.0 negative control group positive controls | 5 5 5 5 5 | 5×1000 5×1000 5×1000 5×1000 5×1000 | 8 9 11 10 155 | 1.6 1.8 2.2 2.0 31.0 ** |
*P＜0.01 (comparing the Poisson distribution inspection) with negative control group
3, mouse sperm deformity test: by table 3 as seen, utmost point significant difference (P＜0.01) is arranged between negative control group mouse sperm deformity rate and the positive controls, the animal sensitivity is described, test is reliable.The difference (P＞0.05) of being tried that there are no significant between each dosage group of thing and the negative control group illustrates that this sample does not have the mouse sperm deformity of causing effect.
Table 3 mouse sperm deformity test-results
| Dosage (g/kgbw) | Number of animals | Examined sperm count | The teratospermia number | Rate of teratosperm (%) |
| 2.5 5.0 10.0 negative control group positive controls | 5 5 5 5 5 | 5×1000 5×1000 5×1000 5×1000 5×1000 | 107 103 116 102 292 | 2.14 2.06 2.32 2.04 5.84 ** |
*X (is compared with negative control group in P＜0.01
2Check)
4, mouse testis chromosomal aberration test: by table 4 as seen, utmost point significant difference (P＜0.01) is arranged between negative control group chromosome aberrations rate and the positive controls, the animal sensitivity is described, test is reliable.The difference (P＞0.05) of being tried that there are no significant between each dosage group of thing and the negative control group illustrates that this sample does not have the mouse testis of causing chromosome aberration effect.
Table 4 mouse testis chromosomal aberration test result
| Dosage (g/kgbw) | The observation of cell number | The chromosome aberration of euchromosome separation property chromosome segregation |
| N ％ N ％ N ％ | ||
| 2.5 5.0 10.0 negative control group positive controls | 5×100 5×100 5×100 5×100 5×100 | 3 0.6 14 2.8 1 0.2 1 0.2 11 2.2 1 0.2 2 0.4 16 3.2 1 0.2 2 0.4 13 2.6 1 0.2 24 4.8 ** 33 6.6 ** 34 6.8 ** |
*P＜0.01 (comparing the t check with negative control group)
Pharmacological test example 2
The immunomodulatory test of the refreshing rich board Wan Defu wine of the present invention
Materials and methods:
Sample: provide by the inventor, be brown liquid.
Laboratory animal: available from Institute of Experimental Animals, Chinese Academy of Medical Sciences's laboratory animal breeding field, healthy Kunming mouse, female, body weight 18-22g.Authentication code is moved word 8707M01 number for the doctor.
Dosage is selected: refreshing rich board Wan Defu wine human body recommended amounts is 50 milliliters/60kg body weight every day, enlarges dosage, i.e. 8.3 milliliters/kg in 10 times of conducts.Upper and lowerly respectively establish a dosage group: 20.0 milliliters/kg (height) and 4.2 milliliters/kg (low). with the wine base with sample ligand to desired concn, set up water control group and wine base control group simultaneously, per os was irritated stomach after 30 days continuously, surveyed every immune indexes.
Instrument and reagent:
Ultraviolet-visible pectrophotometer, electronic balance, electronic digital indicator (precision 0.01mm), microsyringe (50 μ l), CO
2Incubator, constant water bath box, whizzer, slide frame, 200 eye mesh screens, instruments, stopwatch, disposable blood vessel, SRBC, complement (guinea pig serum), Hanks liquid, SA damping fluid, agarose, india ink, the Na of quantitatively getting
2CO
3Solution.
Experimental technique
Delayed allergy (DTH)(the sufficient sole of the foot thickens method)
Mouse peritoneal injection 2% (V/V) SRBC, 4 days left back sufficient sole of the foot thickness of measurement after the sensitization, then at measuring point subcutaneous injection 20% (V/V) SRBC, every mouse is injected 20 μ l, inject and measured left back sufficient sole of the foot portion thickness in back 24 hours, same position is measured three times, gets average. represent the degree of DTH with sufficient sole of the foot thickness difference (swelling degree of the paw) before and after attacking.
The clearance test of mouse carbon
The india ink of mouse tail vein injection 1: 3 dilution treats that prepared Chinese ink injects timing immediately, injects behind the prepared Chinese ink 2,10 minutes, gets blood 20 μ l from the angular vein clump respectively, and it is added to 2 milliliters of Na
2CO
3In the solution, use ultraviolet-visible pectrophotometer at 600nm wavelength place's photometry density value (OD), with Na
2CO
3Solution is made blank, and mouse is put to death, and gets liver and spleen is weighed, and calculates phagocytic index.
Mouse internal organs/body weight ratio
Mouse peritoneal injection SRBC put to death after five days, got thymus gland, spleen is weighed, and calculates internal organs/body weight ratio. and prepare splenocyte suspension simultaneously, carry out antibody-producting cell mensuration.
Antibody-producting cell detects(Jerne improves slide method)
Get spleen, make cell suspension.To mix with the double Hanks liquid of equivalent after the substratum heating for dissolving of top layer, the packing small test tube, 0.5 milliliter of every pipe, in pipe, add 50 μ l 10%SRBC (V/V is with the preparation of SA liquid), 20 μ l splenocyte suspensions again, rapidly behind the mixing, be poured on the slide of brushing the agarose thin layer, after treating that agar solidifies, the slide level buckled be placed on the slide frame, put into CO
2Incubator incubation 1.5 hours, the complement (1: 10) with the dilution of SA liquid joins in the slide frame groove then, continues incubation after 1.5 hours, counting hemolysis plaque number.
Experimental data is set up database with F.xprow software, carries out data analysis with EPI software.
The result
It is as shown in table 5 that health promoting wine of the present invention influences the result to mouse delayed allergy (DTH).
The refreshing rich board Wan Defu wine of table 5 the present invention is to the influence of mouse delayed allergy (DTH)
| Group (milliliter/kg) | Number of animals (only) | Swelling degree of the paw (mm) | *The p value | The #p value |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 15 15 15 15 | 0.19±0.06 0.17±0.05 0.25±0.08 0.27±0.11 0.28±0.09 | ＞0.05 ＞0.05 ＞0.05 ＜0.01 | ＜0.01 ＜0.05 ＜0.01 |
*P value: compare the #p value: compare with wine base control group with the water control group
By table 5 as seen, per os gives the refreshing rich board Wan Defu wine of mouse the present invention 30 days, compares wine base control group, low, middle dosage there was no significant difference (p＞0.05) with the water control group; Compare with wine base control group, low, middle dosage has significant difference (p＜0.01, p＜0.05), can significantly improve the mouse swelling degree of the paw, high dosage can significantly improve the mouse swelling degree of the paw by the utmost point, with water control group and wine base control group utmost point significant difference (p＜0.01) is arranged more all.
Health promoting wine of the present invention is as shown in table 6 to the result of mouse monokaryon-macrophage phagocytic function influence.
The refreshing rich board Wan Defu wine of table 6 the present invention is cleaned up the influence of phagocytic index to mouse monokaryon-scavenger cell carbon
| Group (milliliter/kg) | Number of animals (only) | Phagocytic index (a) | *The p value | The #p value |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 15 15 15 15 | 4.25±1.29 4.11±1.22 4.57±0.88 4.86±0.99 4.81±1.06 | ＞0.05 ＞0.05 ＞0.05 ＞0.05 | ＞0.05 ＞0.05 ＞0.05 |
*P value: compare the #p value: compare with wine base control group with the water control group
By table 6 as seen, per os gives the refreshing rich board Wan Defu wine of mouse 30 days, and wine base control group and water control group be there was no significant difference (p＞0.05) relatively; Basic, normal, high three dosage and water control group and wine base control group relatively there are no significant difference (p＞0.05).
It is as shown in table 7 that health promoting wine of the present invention influences the result to mouse antibodies founder cell number.
The refreshing rich board Wan Defu wine of table 7 the present invention is to the influence of mouse antibodies founder cell number
| Group (milliliter/kg) | Number of animals (only) | Hemolysis plaque number (* 103/ full spleen) | *The p value | The #p value |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 15 15 15 15 | 69.0±43.0 97.4±54.8 139.0±73.1 151.8±62.3 129.3±42.4 | ＞0.05 ＜0.01 ＜0.01 ＜0.01 | ＜0.05 ＜0.01 ＜0.05 |
*P value: compare the #p value: compare with wine base control group with the water control group
By table 7 as seen, per os gives the refreshing rich board Wan Defu wine of mouse 30 days, and wine base control group and water control group be there was no significant difference (p＞0.05) relatively; In dosage can the utmost point significantly improve the antibody-producting cell number of mouse, with water control group and wine base control group utmost point significant difference (p＞0.01) is arranged more all, low, high dosage can significantly improve the antibody-producting cell number of mouse, with the water control group utmost point significant difference (p＜0.01) is arranged more all, utmost point significant difference (p＜0.05) is more all arranged with wine base control group.Wan Defu wine of the present invention is as shown in table 8 to the result of mouse internal organs/body weight ratios affect.
The refreshing rich board Wan Defu wine of table 8 the present invention is to the influence of mouse internal organs/body weight ratio
| Group (milliliter/kg) | Number of animals (only) | Spleen/body weight ratio (g/100g) | *The p value | The #p value | Thymus gland/body weight ratio (g/100g) | *The p value | The #p value |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 15 15 15 15 | 0.74±0.14 0.67±0.14 0.75±0.11 0.72±0.14 0.69±0.11 | ＞0.05 ＞0.05 ＞0.05 ＞0.05 | ＞0.05 ＞0.05 ＞0.05 | 0.25±0.07 0.24±0.06 0.28±0.08 0.30±0.06 0.28±0.05 | ＞0.05 ＞0.05 ＜0.05 ＞0.05 | ＞0.05 ＜0.05 ＞0.05 |
*P value: compare the #p value: compare with wine base control group with the water control group
By table 8 as seen, per os gives the refreshing rich board Wan Defu wine of mouse 30 days, and the spleen of wine base control group mice/body weight ratio and thymus gland/body weight ratio and water control group be there was no significant difference (p＞0.05) relatively; In thymus gland/body weight ratio and water control group and the wine base control group of dosage mouse significant difference (p＜0.05) is more all arranged, the spleen of other dosage group mouse/body weight ratio and thymus gland/body weight ratio and water control group and the comparison of wine base control group there are no significant difference (p＞0.05).
Wan Defu wine of the present invention to the result of mouse body weight influence shown in table 9-12.
Table 9 is respectively organized the initial body weight of mouse
| Group (milliliter/kg) | Two groups of one group of immunity of immunity |
| Number of animals (only) body weight (g) number of animals (only) body weight (g) | |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 20.5±0.9 15 21.1±0.8 15 20.6±1.0 15 20.4±1.0 15 21.1±1.0 15 20.8±1.2 15 20.7±1.0 15 20.6±1.0 15 20.8±1.0 15 20.1±1.4 |
Table 10 is respectively organized the body weight in mid-term of mouse
| Group (milliliter/kg) | Two groups of one group of immunity of immunity |
| Number of animals (only) body weight (g) number of animals (only) body weight (g) | |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 28.5±1.6 15 28.4±1.7 15 28.5±1.7 15 28.4±1.9 15 29.1±2.8 15 29.0±2.2 15 28.9±1.7 15 29.8±1.6 15 28.9±1.6 15 29.4±2.0 |
Table 11 is respectively organized the end body weight of mouse
| Group (milliliter/kg) | Two groups of one group of immunity of immunity |
| Number of animals (only) body weight (g) number of animals (only) body weight (g) | |
| Water contrast wine base contrasts 4.2 8.3 20.0 | 15 30.2±2.2 15 30.2±3.0 15 29.1±2.6 15 29.4±1.4 15 30.6±2.7 15 29.5±3.6 15 30.9±2.6 15 31.0±2.0 15 30.9±1.7 15 29.2±2.1 |
The refreshing rich board Wan Defu wine of table 12 is to the influence of mouse body weight
| Group (milliliter/kg) | One group of immunity | Two groups of immunity | ||||||
| Number of animals (only) | Weightening finish (g) | *The p value | The #p value | Number of animals (only) | Weightening finish (g) | *The p value | The #p value | |
| The water contrast | 15 | 95±1.8 | 15 | 9.1±1.4 | ||||
| The contrast of wine base | 15 | 8.5±2.4 | ＞0.05 | 15 | 9.0±1.7 | ＞0.05 | ||
| 4.2 | 15 | 9.5±2.8 | ＞0.05 | ＞0.05 | 15 | 8.7±4.0 | ＞0.05 | ＞0.05 |
| 8.3 | 15 | 10.2±3.0 | ＞0.05 | ＞0.05 | 15 | 10.4±2.5 | ＞0.05 | ＞0.05 |
| 20.0 | 15 | 10.1±1.8 | ＞0.05 | ＞0.05 | 15 | 9.1±3.8 | ＞0.05 | ＞0.05 |
*P value: compare the #p value: compare with wine base control group with the water control group
By table 12 as seen, per os gives the refreshing rich board Wan Defu wine of mouse 30 days, one group of immunity, the comparison of immune two groups of wine base control groups and water control group there are no significant difference (p＞0.05), basic, normal, high three dosage and water control group and wine base control group relatively there are no significant difference (p＞0.05) illustrates that the mouse growing state is good.
Brief summary
Per os gives the refreshing rich board Wan Defu wine of mouse 30 days, can improve mouse swelling degree of the paw and antibody-producting cell number, and the macrophage phagocytic index is not had influence.The refreshing rich board health promoting wine of prompting has the effect that strengthens cellular immune function and humoral immune function.
Claims (6)
1, a kind of medicated wine composition is characterized in that the preparation raw material of the activeconstituents that it is contained comprises by weight:
The total side 74-94 of nourshing blood and promoting blood circulation part of forming by cultivated land, Radix Angelicae Sinensis, Ligusticum wallichii and the root of herbaceous peony;
The total side 151-189 of enriching yin part of forming by cultivated land, Chinese yam, Fructus Corni, Poria cocos, rhizoma alismatis and the root bark of tree peony;
The total side 320-388 of tonifying Qi part of forming by Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome and Radix Glycyrrhizae;
Kidney-nourishing yang-strengthening medicine 862-1073 part;
Qi-activating drug 94-121 part;
Clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 44-58 part;
The network Shujin anodyne 169-217 part of dispeling the wind, and
Grain wine 13000-28000 part;
Wherein:
The total side of described nourshing blood and promoting blood circulation is by forming in weight part cultivated land 27-33 part, Radix Angelicae Sinensis 21-27 part, Ligusticum wallichii 10-14 part and root of herbaceous peony 16-20 part;
The total side of described enriching yin is by forming in weight part cultivated land 27-33 part, Chinese yam 54-66 part, Fructus Corni 10-14 part, Poria cocos 10-14 part, rhizoma alismatis 5-7 part and root bark of tree peony 45-55 part;
The total side of described tonifying Qi is by forming with weight part Radix Codonopsis 204-244 part, Poria cocos 10-14 part, bighead atractylodes rhizome 16-20 part and Radix Glycyrrhizae 90-110 part;
Described kidney-nourishing yang-strengthening medicine is to be selected from South Dodder Seed Chinese Dodder Seed, Herba Epimedii, shizandra berry, genseng, glossy ganoderma, the root of straight ladybell, Radix Morindae Officinalis, Fructus Cnidii, Herba Cistanches, leek seed, POGUZHI, Ootheca Mantidis, oyster, walnut kernel, donkey-hide gelatin, radix polygonati officinalis, Testis et penis callorhini, Spongilla, wolfberry fruit, hippocampus, sea otter, deer whip or the wide dog whip one or more;
Described qi-activating drug is to be selected from Radix Aucklandiae (Radix Vladimiriae), star anise, agalloch eaglewood, cloves, santal, nutmeg, wide skin or the fructus amomi one or more;
Described clearing up internal heat by using drugs of bitter in taste and cold in nature medicine is selected from one or more in Medulla Junci, cape jasmine or the chrysanthemum;
The described network Shujin anodyne that dispels the wind is to be selected from Stem of Orientoine, Kadsura Pepper Stem, turmeric, pawpaw, Root of Sixpetal Clematis, levisticum, the root of Dahurain angelica, Radix Aconiti Preparata, MALANZI, safflower or the Radix Aconiti Kusnezoffii Preparata one or more.
2, medicated wine composition according to claim 1 is characterized in that the total side 80-88 of the preparation raw material nourshing blood and promoting blood circulation by weight weight part of the activeconstituents that it is contained; The total side 160-180 of enriching yin weight part; The total side 340-360 of tonifying Qi weight part, kidney-nourishing yang-strengthening medicine 880-1050 weight part, qi-activating drug 100-113 weight part, clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 48-55 weight part, network Shujin anodyne 180-206 weight part dispels the wind.
3, medicated wine composition according to claim 2 is characterized in that the total side of preparation raw material nourshing blood and promoting blood circulation by weight 84 weight parts of the activeconstituents that it is contained; The total side of enriching yin 170 weight parts; The total side of tonifying Qi 354 weight parts, kidney-nourishing yang-strengthening medicine 967 weight parts, qi-activating drug 107 weight parts, clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 51 weight parts, network Shujin anodyne 195 weight parts dispel the wind.
4,, it is characterized in that this method comprises the steps: according to the preparation method of the described medicated wine composition of arbitrary claim among the claim 1-3
(a) select following Chinese medicinal materials raw material for use:
Select for use following Chinese medicinal materials clean, dry, be crushed to the above fine powder of 80 orders, take by weighing the Chinese medicinal materials powder according to following dosage by weight then: the total side 74-94 of nourshing blood and promoting blood circulation part; The total side 151-189 of enriching yin part; The total side 320-388 of tonifying Qi part; Kidney-nourishing yang-strengthening medicine 862-1073 part; Qi-activating drug 94-121 part; Clearing up internal heat by using drugs of bitter in taste and cold in nature medicine 44-58 part; The network Shujin anodyne 169-217 part of dispeling the wind;
Wherein: the total side of nourshing blood and promoting blood circulation is by forming in weight part cultivated land 27-33 part, Radix Angelicae Sinensis 21-27 part, Ligusticum wallichii 10-14 part and root of herbaceous peony 16-20 part;
The total side of enriching yin is by forming in weight part cultivated land 27-33 part, Chinese yam 54-66 part, Fructus Corni 10-14 part, Poria cocos 10-14 part, rhizoma alismatis 5-7 part and root bark of tree peony 45-55 part;
The total side of tonifying Qi is by forming with weight part Radix Codonopsis 204-244 part, Poria cocos 10-14 part, bighead atractylodes rhizome 16-20 part and Radix Glycyrrhizae 90-110 part;
(b) above-mentioned Chinese medicinal materials fine powder adopts common high pressure steam sterilization technology to sterilize again;
(c) through the Chinese medicinal materials powder of sterilization 13000-28000 part soaking in Chinese liquor, at room temperature soaked 20-30 days, often stir therebetween;
(d) elimination residue is then converted wine, and is freezing again, filters, and obtains described medicated wine composition like this.
5,, it is characterized in that described kidney-nourishing yang-strengthening medicine is to be selected from South Dodder Seed Chinese Dodder Seed, Herba Epimedii, shizandra berry, genseng, glossy ganoderma, the root of straight ladybell, Radix Morindae Officinalis, Fructus Cnidii, Herba Cistanches, leek seed, POGUZHI, Ootheca Mantidis, oyster, walnut kernel, donkey-hide gelatin, radix polygonati officinalis, Testis et penis callorhini, Spongilla, wolfberry fruit, hippocampus, sea otter, deer whip or the wide dog whip one or more according to the preparation method of the described medicated wine composition of claim 4; Described qi-activating drug is to be selected from Radix Aucklandiae (Radix Vladimiriae), star anise, agalloch eaglewood, cloves, santal, nutmeg, wide skin or the fructus amomi one or more; Described clearing up internal heat by using drugs of bitter in taste and cold in nature medicine is to be selected from Medulla Junci, cape jasmine or the chrysanthemum one or more; The described network Shujin anodyne that dispels the wind is to be selected from Stem of Orientoine, Kadsura Pepper Stem, turmeric, pawpaw, Root of Sixpetal Clematis, levisticum, the root of Dahurain angelica, Radix Aconiti Preparata, MALANZI, safflower or the Radix Aconiti Kusnezoffii Preparata one or more.
6,, it is characterized in that described Chinese medicinal materials is crushed to the 80-120 order according to the preparation method of the described medicated wine composition of claim 4.
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| CN 03149773 CN1216983C (en) | 2003-08-06 | 2003-08-06 | Medicinal wine compsn and its prepn. method |
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| CN1216983C true CN1216983C (en) | 2005-08-31 |
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