CN121102703A - A nasal delivery-based exosome brain delivery device - Google Patents

Abstract

This invention relates to the technical field of drug delivery devices, and discloses an exosome brain delivery device based on nasal delivery, including a drug-carrying mechanism and a delivery mechanism located above the drug-carrying mechanism; the delivery mechanism includes a flexible tube for delivering the solution. This invention effectively prevents nozzle clogging caused by exosome solution residue by using a composite sealing structure of a magnetic sleeve and magnetic ring in a quick-release assembly, combined with a self-closing design of a duckbill valve. The micro-spiral grooves on the inner wall of the nozzle generate a centrifugal force field, significantly reducing the adhesion of viscous drugs to the tube wall. The gripping mechanism innovatively adopts a biomimetic hinge structure of a thumb grip and a middle finger grip, combined with a magnetic slider in the limiting groove to form an adjustable friction surface. Combined with the automatic counterweight function of the gravity balance component, multiple anti-slip contacts are formed on the device surface, solving the problem of unstable grip in traditional devices and significantly improving the stability and accuracy of the exosome nasal delivery process.

Description

Exosome brain conveyor based on nasal delivery

Technical Field

The invention relates to the technical field of drug delivery devices, in particular to an exosome brain delivery device based on nasal delivery.

Background

In recent years, targeted therapies for brain diseases face natural delivery barriers to the Blood Brain Barrier (BBB). Nasal delivery is a research hotspot due to its unique advantages of non-invasiveness, bypassing the BBB, while exosomes are considered ideal brain delivery vehicles due to their natural nanoscale, low immunogenicity, and ability to cross barriers. The technology realizes directional transportation through nose and brain axes by utilizing the surface modification or drug loading of the exosome through the nasal olfactory region/trigeminal nerve pathway, and the feasibility of the technology is verified in animal models such as Alzheimer disease, parkinsonism and the like at present.

The existing nasal cavity delivery device is easy to cause medicine residue and blockage phenomena in the repeated use process of a nozzle due to the special viscosity characteristic of an exosome solution, and directly influences the uniformity of spraying and the accuracy of dosing, and secondly, the appearance design of the device does not fully consider the ergonomics factors, the surface is too smooth and lacks an effective anti-slip structure, so that a user is easy to cause unstable holding during operation, and the accuracy and the use experience of the dosing process are influenced.

Disclosure of Invention

The present invention has been made in view of the above-mentioned problems with the existing nasal delivery-based exosomatic brain delivery devices.

Therefore, the invention aims to provide the exosome brain conveying device based on nasal delivery, which aims to realize efficient atomization, stable conveying and accurate delivery of exosome medicines through a modularized structural design, an anti-blocking nozzle and an ergonomic holding mechanism.

In order to solve the technical problems, the invention provides the following technical proposal that the drug delivery device comprises a drug bearing mechanism and a delivery mechanism positioned above the drug bearing mechanism;

The delivery mechanism comprises a hose for conveying solution, a quick-release assembly arranged at one end of the hose, a nozzle movably connected with the outer side of the quick-release assembly, and a miniature spiral groove arranged on the inner wall of the nozzle;

and a gripping mechanism for use with the delivery mechanism.

As a preferable scheme of the nasal delivery-based exosome brain delivery device, the drug bearing mechanism comprises a liquid storage bin and a slow release buffer fixedly arranged in the center of the top of the liquid storage bin.

As a preferable scheme of the nasal delivery-based exosome brain delivery device, the drug bearing mechanism further comprises a piezoelectric atomizing tube fixedly arranged at the top of the slow release buffer, an adjusting knob hinged at the end part of the piezoelectric atomizing tube, and a micro air pump fixedly arranged at the top of the piezoelectric atomizing tube.

As a preferable scheme of the nasal delivery-based exosome brain delivery device, the other end of the hose is fixedly connected with the top of the miniature air pump and communicated with the top of the miniature air pump.

As an optimal scheme of the nasal delivery-based exosome brain delivery device, the quick-release assembly comprises a magnetic suction sleeve fixedly arranged at the end part of the hose and a magnetic suction ring fixedly arranged in the inner cavity of the magnetic suction sleeve.

As an optimal scheme of the exosome brain conveying device based on nasal delivery, the quick-dismantling component further comprises a cannula movably inserted into the inner cavity of the magnetic suction sleeve and a duckbill valve fixedly arranged at the end part of the cannula.

As a preferable scheme of the nasal delivery-based exosome brain delivery device, the holding mechanism comprises a thumb holding rod, a middle finger holding rod hinged at the end part of the thumb holding rod and a gravity balance assembly arranged outside the middle finger holding rod.

As a preferable scheme of the exosome brain conveying device based on nasal delivery, the holding mechanism further comprises a limiting channel arranged on the outer side of the middle finger holding rod, a groove plate fixedly arranged on the outer side of the middle finger holding rod, a magnetic sliding sheet movably clamped in the inner cavity of the groove plate, a through hole arranged in the inner cavity of the middle finger holding rod, a damping shaft sleeve hinged to the end part of the thumb holding rod, and a limiting clamping sleeve hinged to the top of the damping shaft sleeve, wherein the limiting clamping sleeve is movably sleeved at one end of the hose close to the delivery mechanism.

As an optimal scheme of the nasal delivery-based exosome brain delivery device, the gravity balance assembly comprises a movable rod movably clamped in the inner cavity of the through hole and a limiting collar fixedly sleeved on the outer side of the movable rod.

As a preferable scheme of the nasal delivery-based exosome brain delivery device, the gravity balance assembly further comprises a reset spring fixedly arranged on the outer side of the limiting clamping ring and a supporting holding rod fixedly arranged at the end part of the reset spring.

The quick-dismantling device has the beneficial effects that the quick-dismantling component adopts the composite sealing structure of the magnetic suction sleeve and the magnetic suction ring, the self-closing design of the duckbill valve is matched, the problem of nozzle blockage caused by exosome solution residue is effectively prevented, the micro spiral groove arranged on the inner wall of the nozzle obviously reduces the adhesion of viscous medicine on the pipe wall by generating a centrifugal force field, the holding mechanism innovates a bionic hinge structure of the thumb holding rod and the middle finger holding rod, an adjustable friction surface is formed by combining the magnetic suction sliding sheets in the limiting channel, the automatic counterweight function of the gravity balance component is matched, the multipoint anti-skid contact is formed on the surface of the device, the problem of unstable holding of the traditional device is solved, and the stability and the accuracy of the exosome nasal cavity delivery process are obviously improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art. Wherein:

Fig. 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a schematic view of a structure of a holding mechanism according to the present invention.

FIG. 3 is a partial cross-sectional view of the quick release assembly of the present invention.

FIG. 4 is a cross-sectional view of the holding mechanism and the weight balance assembly of the present invention.

Fig. 5 is a schematic view of a quick release assembly of the present invention.

Fig. 6 is a schematic view of a part of the structure of the holding mechanism of the present invention.

In the figure:

100. the device comprises a medicine bearing mechanism, 110 parts of a liquid storage bin, 120 parts of a slow-release buffer, 130 parts of a piezoelectric atomizing tube, 140 parts of an adjusting knob, 150 parts of a micro air pump;

200. Delivery mechanism, 210, hose, 220, quick-release component, 221, magnetic sleeve, 222, magnetic ring, 223, cannula, 224, duckbill valve, 230, nozzle, 240, micro spiral groove;

300. The hand-held device comprises a holding mechanism, 310, a thumb holding rod, 320, a middle finger holding rod, 330, a gravity balance assembly, 331, a movable rod, 332, a limiting clamping ring, 333, a return spring, 334, a supporting holding rod, 340, a limiting channel, 350, a groove plate, 360, a magnetic attraction sliding sheet, 370, a through hole, 380, a damping shaft sleeve, 390 and a limiting clamping sleeve.

Detailed Description

In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways other than those described herein, and persons skilled in the art will readily appreciate that the present invention is not limited to the specific embodiments disclosed below.

Further, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic can be included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.

Further, in describing the embodiments of the present invention in detail, the cross-sectional view of the device structure is not partially enlarged to a general scale for convenience of description, and the schematic is only an example, which should not limit the scope of protection of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in actual fabrication.

Example 1

Referring to fig. 1-6, in a first embodiment of the present invention, there is provided a nasal delivery-based exosome brain delivery device, the device including a drug-carrying mechanism 100 and a delivery mechanism 200 above the drug-carrying mechanism 100;

the delivery mechanism 200 comprises a hose 210 for delivering a solution, a quick-release assembly 220 arranged at one end of the hose 210, a nozzle 230 movably connected with the outer side of the quick-release assembly 220, and a micro spiral groove 240 arranged on the inner wall of the nozzle 230;

And a gripping mechanism 300 for use with the delivery mechanism 200.

The drug carrying mechanism 100 and the delivery mechanism 200 are arranged in an up-down split mode, so that the modularized separation of drug storage and delivery functions is realized, the maintenance and disinfection of the device are facilitated, the delivery mechanism 200 adopts the nozzle 230 with the micro spiral groove 240 to be combined with the quick-release assembly 220, stable vortex of atomized drugs can be ensured to be formed, the delivery efficiency is improved, the disassembly and assembly process of the nozzle 230 is simplified, and the additionally arranged holding mechanism 300 provides an operation basis conforming to ergonomics for the whole device.

Specifically, the drug carrying mechanism 100 includes a reservoir 110, a slow release buffer 120 fixedly installed in the center of the top of the reservoir 110, a piezoelectric atomizing tube 130 fixedly installed at the top of the slow release buffer 120, an adjusting knob 140 hinged at the end of the piezoelectric atomizing tube 130, and a micro air pump 150 fixedly installed at the top of the piezoelectric atomizing tube 130, wherein the other end of the hose 210 is fixedly connected with the top of the micro air pump 150 and is mutually communicated.

The hierarchical layout of the liquid storage bin 110 and the slow release buffer 120 enables the exosome solution to enter the conveying link after the physical and chemical properties of the exosome solution are stabilized by the slow release buffer 120, so that inactivation of the active ingredients of the medicine due to sudden pressure change is effectively avoided, the centrally arranged structure of the slow release buffer 120 ensures that the medicine can uniformly flow into a downstream atomization assembly, the vertical stacking design of the piezoelectric atomization tube 130 and the micro air pump 150 realizes the dual functions of medicine atomization and conveying in a limited space, the hinged structure of the adjusting knob 140 enables a user to accurately control the atomized particle size according to individual requirements, and the top positioning of the micro air pump 150 forms an optimal airflow conduction path;

The direct connection between the hose 210 and the top of the micro air pump 150 eliminates the air flow loss caused by the conventional lateral connection, and the arrangement enables atomized medicine to enter the delivery channel along the shortest path, thereby significantly reducing the adhesion loss of the medicine during the delivery process.

Still further, the quick release assembly 220 includes a magnetic suction sleeve 221 fixedly mounted at the end of the hose 210, a magnetic suction ring 222 fixedly mounted in the inner cavity of the magnetic suction sleeve 221, a cannula 223 movably inserted in the inner cavity of the magnetic suction sleeve 221, and a duckbill valve 224 fixedly mounted at the end of the cannula 223.

Wherein, quick detach subassembly 220 is inhaled through magnetism and is inhaled the cover 221 and is inhaled the dual magnetism of ring 222 and fix, has realized the single hand quick assembly disassembly of nozzle 230 when guaranteeing the connection leakproofness, and this structure is applicable to the clinical application scene that needs frequent nozzle 230 of changing, and intubate 223 and duckbill valve 224's combined design has both kept the rigid support of conveying line through the grafting structure, has utilized duckbill valve 224's self-closing characteristic to prevent medicine backward flow and external pollution again, has double ensure conveying system's health safety.

When the device is used, an exosome drug solution is injected into the liquid storage bin 110, enters the piezoelectric atomizing tube 130 after being stabilized by the slow release buffer 120, the atomized particle size is controlled by the adjusting knob 140, air flow is generated by the micro air pump 150, the atomized drug is conveyed to the delivery mechanism 200 through the hose 210, backflow is prevented through the duckbill valve 224 in the quick-dismantling component 220, finally, vortex is formed through the nozzle 230 with the micro spiral groove 240, the precise nasal cavity is sprayed, in the whole process, the gravity center of the holding mechanism 300 is automatically adjusted through the gravity balance component 330, the delivery stability and the operation comfort are ensured, and the efficient and precise brain targeted delivery of the exosome drug is realized.

In summary, the drug carrying mechanism 100 adopts the liquid storage bin 110 and the sustained-release buffer 120 which are distributed in a hierarchical manner to ensure the stable activity of the drug, the piezoelectric atomizing tube 130 vertically stacked and the miniature air pump 150 connected at the top are matched to realize efficient atomization, the delivery mechanism 200 generates stable vortex through the nozzle 230 with the miniature spiral groove 240, the magnetic quick-release assembly 220 and the duckbill valve 224 are combined to ensure the tightness and facilitate the disassembly and assembly, the ergonomic holding mechanism 300 improves the operation stability and comfort through the gravity balance and the adjustable design, and finally, the accurate control and the efficient delivery of the whole process from the storage, the atomization to the nasal cavity targeted delivery of the exosome drug are realized.

Example 2

Referring to fig. 1,2, 4 and 6, a second embodiment of the present invention is a gripping mechanism 300 that differs from the first embodiment in that it provides optimized gripping stability and operational flexibility.

Further, the holding mechanism 300 includes a thumb grip 310, a middle finger grip 320 hinged at the end of the thumb grip 310, and a gravity balance assembly 330 disposed outside the middle finger grip 320, the holding mechanism 300 further includes a limit channel 340 formed outside the middle finger grip 320, a slot plate 350 fixedly mounted outside the middle finger grip 320, a magnetic attraction slide 360 movably clamped in the cavity of the slot plate 350, a through hole 370 formed in the cavity of the middle finger grip 320, a damping sleeve 380 hinged at the end of the thumb grip 310, and a limit sleeve 390 hinged at the top of the damping sleeve 380, wherein the limit sleeve 390 is movably sleeved at one end of the hose 210 near the delivery mechanism 200.

The hinge structure of the thumb grip 310 and the middle finger grip 320 simulates the natural holding gesture of a human body, the gravity balance assembly 330 dynamically adjusts the gravity center of the device, the combined design significantly improves the holding stability of a single hand, the combined design is particularly suitable for parkinsonism hand tremble patients, the limit channel 340 and the magnetic sliding piece 360 form an adjustable holding surface, the device can adapt to users with different palm sizes by matching with the slow rotation characteristic of the damping shaft sleeve 380, and the limit clamping sleeve 390 flexibly fixes the hose 210, so that the bending of a pipeline is avoided, and the interference of operation vibration on drug delivery is reduced.

Further, the gravity balance assembly 330 includes a movable rod 331 movably clamped in the cavity of the through hole 370, a limiting collar 332 fixedly sleeved on the outer side of the movable rod 331, a return spring 333 fixedly mounted on the outer side of the limiting collar 332, and a supporting holding rod 334 fixedly mounted on the end of the return spring 333.

Wherein, the restriction of the sliding fit limit collar 332 of movable rod 331 in through hole 370 constitutes self-adaptation counter weight mechanism, can be according to device inclination automatic adjustment balancing moment, ensures that homoenergetic keeps stable spraying orbit under different operating attitudes, and return spring 333 and the elastic connection design who supports holding rod 334, when providing enough resistance of holding, absorb the unexpected impact force when operating through spring deformation, both guarantee accurate dosing and can avoid the mechanical damage that leads to because of the power is too hard.

When the device is held by a single hand of a patient, the thumb and the middle finger are naturally attached to the thumb holding rod 310 and the middle finger holding rod 320, the gravity balance assembly 330 adjusts the gravity center of the device in real time to adapt to the change of an operation angle, the damping shaft sleeve 380 and the limiting clamping sleeve 390 cooperate to stabilize the hose 210, the drug delivery process is ensured not to be affected by the micro vibration of the hand, the holding position of the magnetic sliding sheet 360 can be adjusted according to the requirement, and the operation comfort level is further optimized.

In summary, the ergonomic gripping structure and dynamic balance system of the gripping mechanism 300 significantly improves the operational stability and adaptability of the device, making the exosomatic brain delivery process more accurate and reliable.

Example 3

Referring to fig. 1 to 6, a third embodiment of the present invention, unlike the previous embodiment, provides a method of using an exosome brain delivery device based on nasal delivery, the method comprising the steps of:

S1, injecting an exosome drug solution into a liquid storage bin 110, ensuring that a slow release buffer 120 is firmly connected with a piezoelectric atomization tube 130, checking the tightness of a quick release assembly 220 and a nozzle 230, and adjusting a holding mechanism 300 to a proper holding position of a user;

S2, setting proper atomization parameters through the adjusting knob 140, starting the micro air pump 150 and the piezoelectric atomization tube 130, so that the drug solution forms uniform micron-sized atomized particles in the piezoelectric atomization tube 130, and delivering the atomized drug to the delivery mechanism 200 through the hose 210;

S3, aligning the nozzle 230 with the nasal cavity entrance of a user, automatically adjusting the gravity center of the device by the gravity balance assembly 330 of the holding mechanism 300, keeping a stable delivery angle, and ensuring that atomized medicine is accurately guided to the olfactory region along the nasal passage;

S4, turning on a delivery switch, enabling atomized medicine to form rotary air flow under the guidance of the micro spiral groove 240, enabling the atomized medicine to enter the nasal cavity at a stable flow rate and in a stable direction through the unidirectional flow characteristic of the duckbill valve 224, enabling the atomized medicine to be absorbed by nasal mucosa and then delivered to a target brain area in a targeted mode, turning off a power supply of the equipment after the medicine delivery process is completed, and disassembling the nozzle 230 for cleaning and disinfection.

In conclusion, the use method realizes the whole process accurate control from loading to atomization to brain targeted delivery of the exosome medicine by optimizing the operation flow and the equipment cooperative work mode.

It is important to note that the construction and arrangement of the application as shown in the various exemplary embodiments is illustrative only. Although only a few embodiments have been described in detail in this disclosure, those skilled in the art who review this disclosure will readily appreciate that many modifications are possible (e.g., variations in sizes, dimensions, structures, shapes and proportions of the various elements, values of parameters (e.g., temperature, pressure, etc.), mounting arrangements, use of materials, colors, orientations, etc.) without materially departing from the novel teachings and advantages of the subject matter described in this application. For example, elements shown as integrally formed may be constructed of multiple parts or elements, the position of elements may be reversed or otherwise varied, and the nature or number of discrete elements or positions may be altered or varied. Accordingly, all such modifications are intended to be included within the scope of present application. The order or sequence of any process or method steps may be varied or re-sequenced according to alternative embodiments. In the claims, any means-plus-function clause is intended to cover the structures described herein as performing the recited function and not only structural equivalents but also equivalent structures. Other substitutions, modifications, changes and omissions may be made in the design, operating conditions and arrangement of the exemplary embodiments without departing from the scope of the present applications. Therefore, the application is not limited to the specific embodiments, but extends to various modifications that nevertheless fall within the scope of the appended claims.

Furthermore, in an effort to provide a concise description of the exemplary embodiments, all features of an actual implementation may not be described (i.e., those not associated with the best mode presently contemplated for carrying out the invention, or those not associated with practicing the invention).

It should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered in the scope of the claims of the present invention.

Claims (10)

1. An exosomatic brain delivery device based on nasal delivery is characterized by comprising a drug bearing mechanism (100) and a delivery mechanism (200) positioned above the drug bearing mechanism (100);

The delivery mechanism (200) comprises a hose (210) for conveying a solution, a quick-release assembly (220) arranged at one end of the hose (210), a nozzle (230) movably connected with the outer side of the quick-release assembly (220), and a micro spiral groove (240) formed in the inner wall of the nozzle (230);

And a gripping mechanism (300) for use with the delivery mechanism (200).

2. The nasal delivery-based exosome brain delivery device of claim 1, wherein the drug-carrying mechanism (100) comprises a reservoir (110) and a slow release buffer (120) fixedly mounted in a top center of the reservoir (110).

3. The nasal delivery-based exosome brain delivery device of claim 2, wherein the drug-carrying mechanism (100) further comprises a piezoelectric nebulizing tube (130) fixedly mounted on top of the slow release buffer (120), an adjusting knob (140) hinged at an end of the piezoelectric nebulizing tube (130), and a micro air pump (150) fixedly mounted on top of the piezoelectric nebulizing tube (130).

4. The nasal delivery-based exosome brain delivery apparatus according to claim 3, wherein the other end of the flexible tube (210) is fixedly connected to the top of the micro air pump (150) and is communicated with each other.

5. The nasal delivery-based exosome brain delivery apparatus according to claim 4 wherein the quick release assembly (220) comprises a magnetic suction sleeve (221) fixedly mounted at an end of the hose (210) and a magnetic suction ring (222) fixedly mounted in an inner cavity of the magnetic suction sleeve (221).

6. The nasal delivery-based exosome brain delivery apparatus according to claim 5 wherein the quick release assembly (220) further comprises a cannula (223) movably inserted into the lumen of the magnetic sleeve (221) and a duckbill valve (224) fixedly mounted at an end of the cannula (223).

7. The nasal delivery-based exosome brain delivery device of claim 6, wherein the gripping mechanism (300) comprises a thumb grip (310), a middle finger grip (320) hinged at an end of the thumb grip (310), and a gravity balance assembly (330) disposed outside of the middle finger grip (320).

8. The nasal delivery-based exosome brain conveyor of claim 7, wherein the holding mechanism (300) further comprises a limiting channel (340) arranged on the outer side of the middle finger holding rod (320), a groove plate (350) fixedly arranged on the outer side of the middle finger holding rod (320), a magnetic sliding sheet (360) movably clamped in an inner cavity of the groove plate (350), a through hole (370) arranged in the inner cavity of the middle finger holding rod (320), a damping shaft sleeve (380) hinged at the end part of the thumb holding rod (310), and a limiting cutting sleeve (390) hinged at the top of the damping shaft sleeve (380), wherein the limiting cutting sleeve (390) is movably sleeved at one end of the hose (210) close to the delivery mechanism (200).

9. The nasal delivery-based exosome brain delivery device of claim 8, wherein the gravity balance assembly (330) comprises a movable rod (331) movably clamped in the inner cavity of the through hole (370), and a limiting collar (332) fixedly sleeved outside the movable rod (331).

10. The nasal delivery-based exosome brain delivery device of claim 9, wherein the gravity balance assembly (330) further comprises a return spring (333) fixedly mounted outside the stop collar (332), and a support grip (334) fixedly mounted at an end of the return spring (333).