CN1211099C

CN1211099C - Zhenggutongbi pill for curing bone disunion, aseptic bone necrosis and chronic osteomyelitis and its preparing method

Info

Publication number: CN1211099C
Application number: CNB011141077A
Authority: CN
Inventors: 周成刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-06-19
Filing date: 2001-06-19
Publication date: 2005-07-20
Anticipated expiration: 2021-06-19
Also published as: CN1391917A

Abstract

The present invention discloses a new Zhenggutongbi pill for treating bone non-concrescence, aseptic bone necrosis and chronic osteomyelitis. The pill comprises hairy antler, angelica, astragalus roots, codonopsis pilosula, eupolyphaga, honeysuckle flowers, myrrh, rhizoma drynariae and cinnamon as raw materials. According to the different characteristics of each kind of the traditional Chinese medicines, the present invention has three effects by one dosage, and has the characteristics of obvious therapeutic effect, high safety and reliability and short course of treatment, and meanwhile, the treat expense is low so that patients can easily accept treatment without pain.

Description

Zhenggutongbi pill of treatment nonunion, aseptic necrosis of bone, chronic osteomyelitis and preparation method thereof

The present invention relates to a kind of Zhenggutongbi pill for the treatment of nonunion, aseptic necrosis of bone, chronic osteomyelitis, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.

Treatment nonunion, aseptic necrosis of bone, the common method that adopts of chronic osteomyelitis orthopaedic disease are that the patient is implemented surgical operation and takes relevant medicine at present, and said method exists the not obvious problem of bringing very big misery to the patient that reaches of therapeutic effect.

The object of the present invention is to provide a kind of have therapeutic effect obviously, the Zhenggutongbi pill of the nonunion of short treating period, aseptic necrosis of bone, chronic osteomyelitis.

Another object of the present invention provides the preparation method of the medicine of treatment nonunion, aseptic necrosis of bone, chronic osteomyelitis.

Solution of the present invention is based on pathogeny understanding and the Therapeutic Principle of motherland's medical science to orthopaedic diseases such as nonunion, aseptic necrosis of bone, chronic osteomyelitiss, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the kidney tonifying essence, fill blood, change stasis of blood poison in the bone, the natural food medicine of reducing swelling and alleviating pain, benefit bone tissue regeneration promoting forms, by the theory of Chinese medical science prescription, skim the cream off milk, make it give play to the promotion inostosis, improve local microcirculation, regulate calcium balance in the animal body, thereby reach the purpose of alleviating and curing above-mentioned orthopaedic disease.

Medicine of the present invention is made by following component: (consumption is a weight portion)

Cornu Cervi Pantotrichum 1～5 Radix Angelicae Sinensis 15～30 Radixs Astragali 25～50 Radix Codonopsis 15～20

Eupolyphage sece steleophaga 15～20 Flos Loniceraes 25～50 Myrrhas 15～20 Rhizoma Drynariae 20～25

Cortex Cinnamomi 5～10

Formula optimization weight (part) ratio range of preparation medicine of the present invention is:

Cornu Cervi Pantotrichum 2～5 Radix Angelicae Sinensis 15～25 Radixs Astragali 30～45 Radix Codonopsis 16～20

Eupolyphage sece steleophaga 15～19 Flos Loniceraes 30～45 Myrrhas 16～20 Rhizoma Drynariae 20～24

Cortex Cinnamomi 6～10

The optimum weight of medicine of the present invention (part) proportioning is:

Cornu Cervi Pantotrichum 3 Radix Angelicae Sinensis 25 Radixs Astragali 35 Radix Codonopsis 16

Eupolyphage sece steleophaga 19 Flos Loniceraes 35 Myrrhas 17 Rhizoma Drynariae 22

Cortex Cinnamomi 6

Above-mentioned each component is made medicine production method of the present invention is:

1, raw material is prepared according to the above ratio, crushed after being dried is to fine powder;

2, cross 100 mesh sieve, add proper honey then and mix stirring, send into the pellet processing machine pill;

3,, put shady and cool dry place with 60 ℃ of dry for standby of water-honeyed pill of making.

An important feature of the present invention is by promoting the growth of fracture site blood capillary, improve blood circulation, promotion bone trabecula hypertrophy and the callus formation of fracture, improve calcium balance in the animal body, the absorption of regulating calcium and storage such as stay at approach, shortening healing time; Can reduce whole blood viscosity and plasma viscosity simultaneously, improve blood, blood vessel is grown into, improve the macrophage phagocytic ability, absorb downright bad sclerotin, thereby be beneficial to sclerotin reparation and regeneration for promoting blood capillary proliferation; And can quicken the liquefaction of osteomyelitis slough and come off and fibroblasts proliferation, microcirculation improvement is removed slough and metabolite, promotes healing, skeletonization.

Another important feature of the present invention is to contain abundant nutrition in the medicament, wherein contains a large amount of vegetable proteins, and contains several amino acids.

In medicament of the present invention, also contain various trace elements such as calcareous element in addition and kill the composition of various bacteria.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, selecting natural drug for use is raw material, meets the basic combination principle of science of prescription.Utilize comprehensive function treatment nonunion, aseptic necrosis of bone, the chronic osteomyelitis of the Chinese medicine of respectively distinguishing the flavor of that human body is had no side effect.

2, the present invention need not decoct, no bitterness sense, nutritious, taking convenience.

3, all suitable to light, heavy patient, therapeutic effect is obvious.Realized that potion three controls the rule that meets traditional Chinese medical science treating different diseases with the same therapeutic principle; Medical expense is low, short treating period, patient's no pain, is easy to promote.

For showing the therapeutic effect of medicine of the present invention to nonunion, aseptic necrosis of bone, chronic osteomyelitis orthopaedic disease, the present invention selects 240 cases to carry out system's clinical observation through reaching Orthopaedics Clinic from being in hospital, wherein male 180 examples, woman's 60 examples, 30～56 years old age, the course of disease 1～6 year, wherein nonunion (A) 48, aseptic necrosis of bone (B) 49, chronic osteomyelitis (C) 49, the concurrent aseptic necrosis of bone of nonunion (AB) 53 examples, the concurrent nonunion of osteomyelitis (AC) 41 examples, basic condition sees Table 1.

The disease n men and women age course of disease (year)

A 48 34 12 44.3+_11.5 3.25+_1.68

B 49 38 12 43.1+_12.3 2.91+_1.76

C 49 36 11 43.8+_10.5 3.78+_2.10

AB 53 35 10 45.7+_11.2 3.32+1.93

AC 41 37 15 42.4+_9.8 3.93+_0.99

The clinical physical data of table 1 relatively

Above-mentioned 240 routine patients are implemented Drug therapy of the present invention, instructions of taking: 10 grams/time, day three warm yellow wine of clothes are taken after mixing it with water, diet Chinese liquor and congee with mung beans, and three months observation periods, 1 month is a course of treatment, totally 3 courses of treatment; After the patient takes this medicine, carry out the X line and take the photograph the sheet inspection, the results are shown in Table 2

Position example number efficacy evaluation

A B C AB AC BC clinical healing produce effects enabledisable

Numerical example % numerical example % numerical example % numerical example %

Humerus 309060 16 (88.8) 1 (5.5) 1 (5.5) 0 (0)

Ulna 803040 14 (93.3) 1 (7.1) 0 (0) 0 (0)

Radius 504030 11 (91.6) 1 (8.3) 0 (0) 0 (0)

Pelvic bone 0003002 (66.6) 1 (33.3) 0 (0) 0 (0)

Neck of femur head 17 42 3 48 40 109 (95.6) 3 (2.6) 2 (1.7) 0 (0)

Femur 12 4 11 2 15 0 40 (90.9) 3 (6.8) 1 (2.2) 0 (0)

Tibia 30 19 090 28 (90.3) 2 (6.4) 1 (3.2) 0 (0)

Shank 0300002 (66.6) 1 (33.3) 0 (0) 0 (0)

Annotate: A-nonunion B-aseptic necrosis of bone C-chronic osteomyelitis

(1) clinical healing: clinical symptoms, sign disappearance X ray examination recover normal

(2) produce effects: clinical symptoms, the sign X line that obviously disappears is taken the photograph the sheet area of new bone and is accounted for

(+++--+) bone damaged 80%

(3) effective: clinical symptoms, sign alleviate the X line and take the photograph the sheet area of new bone and account for

(+++-++--+) the damaged 40%-60% of bone

(4) invalid: treatment symptom, sign and X line are taken the photograph the sheet index is not had the improver

Table 2 nonunion, aseptic necrosis of bone, chronic osteomyelitis curative effect statistical table

After 1-3 month course of therapy of 240 routine patients' processes, 222 examples of fully recovering, produce effects 13 examples, effective 5 examples, total cure rate is 92.5%, and effective percentage is 100%, and check is followed up a case by regular visits to through 3-5, and no case was recurrence.No any significant discomfort and toxicity during medication are checked after treatment finishes simultaneously, and liver, renal function are all in normal range.

Animal modeling grouping experiment result

1, after chronic osteomyelitis is got 30 rat etherizations, cuts femur place skin, expose femur and will sew up in the bacterium liquid injection medullary cavity; Be divided into 10 every group three groups, take medicament of the present invention for first group, take the oxytetracycline matched group for second group, the 3rd group is model control group, and the administration phase is 90 days.

Contrast X ray examination result

Model group is destroyed the sequestrum that differing in size appears in the cavity district, sclerotin increase in density shadow around the district of cavity, and the bone profile increases slightly, and cortical thickening is periosteal proliferation; Taking around the medicament group of the present invention treatment is that as seen to increase thick bone deformation thin, cortex attenuation, edge clear, higher, the edge clear in focus bone defective region density outside during seven weeks, no sequestrum, medullary cavity formation during 12 weeks, cortical bone plasticity; The oxytetracycline group is to take medicament group of the present invention similar, but the osteoporosis decalcification is more obvious, and fibrous tissue is arranged sparse.

2, after nonunion is got 30 rat etherizations, radius is sawn into horizontal type fracture, postoperative 8 all X ray examinations turn out to be nonunion; Divide per 10 one group three groups, take medicament of the present invention for one group, take GUZHE CUOSHANG JIAONANG for two groups, three groups is model control group.

Contrast X ray examination result

Callus formation is obvious after taking 5 weeks of medicament group treatment of the present invention, fracture line disappears, bone trabecula is high-visible after 8 weeks, medullary cavity density is recovered substantially, and 12 all former focal zones and fracture end are full of a large amount of newborn lamellar bones, and bone density is evenly normal, model group callus index is lower, the medullary cavity sealing, most bones are damaged greater than 1mm, and displacement is arranged.Taking the GUZHE CUOSHANG JIAONANG group has the part callus formation during 8 weeks, and 12 all bone trabecula as seen.

3, aseptic necrosis of bone is got 10 of rabbits, after the intravenous anesthesia, uses the liquid nitrogen freezing femoral head, and the back X-ray examination of 2 weeks confirms that ischemic necrosis appears in femoral head; Be divided into 5 every group two groups, take another group of medicament of the present invention for one group and be the rabbit matched group of performing an operation.

Contrast X ray examination is matched group 4 all femoral head quality capsule transparent areas as a result, and the femoral head dislocation is arranged, and look into individually and see that sclerotin is cracked, and articular surface is rough, and the joint space changes.The damaged transparent area density of the group of taking medicine treatment 4 week back bone ecto-entad increases gradually, and sequestrum lowers with the sclerosis bone density.Improve the joint space, and the femoral head of displacement resets substantially, and as seen cracked sclerotin is repaired.The joint space is clear, normal during 8 weeks.Bone density is normal substantially during 12 weeks.

Therefore, with other drug relatively have therapeutic effect significantly, the characteristics of instant effect, short treating period, and can realize the effect that potion three is controlled.

Embodiment

Take by weighing raw material (kilogram) by following proportioning

Cortex Cinnamomi 6

Production method is as follows:

1, raw material is prepared according to the above ratio, crushed after being dried is to fine powder:

Claims

1, a kind of bonesetting arthralgia aggravated by cold pellet for the treatment of nonunion, aseptic necrosis of bone, chronic osteomyelitis is characterized in that it is the medicament of being made by the following weight proportion raw material:

Cornu Cervi Pantotrichum 1-5 Radix Angelicae Sinensis 15-30 Radix Astragali 25-50 Radix Codonopsis 15-20

Eupolyphage sece steleophaga 15-20 Flos Lonicerae 25-50 Myrrha 15-20 Rhizoma Drynariae 20-25

Cortex Cinnamomi 5-10.

2, the bonesetting arthralgia aggravated by cold pellet of treatment nonunion according to claim 1, aseptic necrosis of bone, chronic osteomyelitis, wherein the weight proportion of each raw material is:

Cornu Cervi Pantotrichum 2-5 Radix Angelicae Sinensis 15-25 Radix Astragali 30-45 Radix Codonopsis 16-20

Eupolyphage sece steleophaga 15-19 Flos Lonicerae 30-45 Myrrha 16-20 Rhizoma Drynariae 20-24

Cortex Cinnamomi 6-10.

3, the bonesetting arthralgia aggravated by cold pellet of treatment nonunion according to claim 1, aseptic necrosis of bone, chronic osteomyelitis, wherein the weight proportion of each raw material is:

Cortex Cinnamomi 6.

4, according to the bonesetting arthralgia aggravated by cold pellet of claim 1 or 2 or 3 described treatment nonunions, aseptic necrosis of bone, chronic osteomyelitis, it is characterized in that said medicament is powder or pill.

5, the bonesetting arthralgia aggravated by cold pellet of treatment nonunion according to claim 4, aseptic necrosis of bone, chronic osteomyelitis is characterized in that raw material is prepared according to the above ratio, and crushed after being dried is to fine powder; Cross 100 mesh sieve, add proper honey then and mix stirring, send into the pellet processing machine pill; With 60 ℃ of dry for standby of water-honeyed pill of making, put shady and cool dry place.