CN120406632A - Continuous blood glucose monitoring device control method, device and equipment - Google Patents
Continuous blood glucose monitoring device control method, device and equipmentInfo
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- CN120406632A CN120406632A CN202510912656.9A CN202510912656A CN120406632A CN 120406632 A CN120406632 A CN 120406632A CN 202510912656 A CN202510912656 A CN 202510912656A CN 120406632 A CN120406632 A CN 120406632A
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Abstract
The invention relates to a control method, a device and equipment of continuous blood glucose monitoring equipment, wherein the continuous blood glucose monitoring equipment comprises an electrochemical sensor, the method comprises the steps of loading corresponding bias voltages to a working electrode of the electrochemical sensor and an auxiliary electrode of the electrochemical sensor respectively, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose, detecting to obtain an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode, determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, and adjusting the bias voltage loaded to the auxiliary electrode under the condition that the absolute value of the difference between the first voltage difference and the second voltage difference is larger than a preset threshold value, so that the absolute value of the difference between the first voltage difference and the second voltage difference is smaller than or equal to the preset threshold value.
Description
Technical Field
The present disclosure relates to blood glucose monitoring technology, and more particularly, to a continuous blood glucose monitoring device control method, apparatus, and device.
Background
In a continuous glucose monitoring (Continuous Glucose Monitoring, CGM) device, glucose in a tissue fluid reacts electrochemically with an active substance on an electrochemical sensor to generate an electrical current, based on which the concentration of glucose in the tissue fluid can be determined.
In addition to glucose, various electrochemically active substances, such as uric acid, ascorbic acid and the like, exist in tissue fluid, and these substances also react electrochemically on an electrochemical sensor to generate interference signals, which affect the accuracy and stability of glucose measurement.
Therefore, it is necessary to provide a technical solution to suppress the reaction of the interfering substances in the tissue fluid and realize noise reduction.
Disclosure of Invention
An object of the present invention is to provide a new technical solution for a control method of a continuous blood glucose monitoring device.
According to a first aspect of the present invention, there is provided a method of controlling a continuous blood glucose monitoring device, the continuous blood glucose monitoring device comprising an electrochemical sensor, the method comprising:
Respectively loading corresponding bias voltages for a working electrode of the electrochemical sensor and an auxiliary electrode of the electrochemical sensor, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose;
Detecting to obtain an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode;
Determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
And under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is larger than a preset threshold value, adjusting the bias voltage loaded to the auxiliary electrode so that the absolute value of the difference value of the first voltage difference and the second voltage difference is smaller than or equal to the preset threshold value.
Optionally, the bias voltage applied to the working electrode is a voltage required to satisfy the electrochemical reaction of glucose at the electrochemical sensor.
Optionally, the adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes:
increasing a bias voltage applied to the auxiliary electrode in the case that the second voltage difference is greater than the first voltage difference;
And reducing the bias voltage applied to the auxiliary electrode in the case that the second voltage difference is smaller than the first voltage difference.
Optionally, the adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes:
adjusting bias voltage loaded to the auxiliary electrode based on a preset voltage step length;
Re-detecting to obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
Determining a new second voltage difference according to the actual voltage value of the working electrode obtained through re-detection and the actual voltage value of the auxiliary electrode obtained through re-detection;
and under the condition that the absolute value of the difference value of the first voltage difference and the new second voltage difference is larger than a preset threshold value, continuously adjusting the bias voltage loaded to the auxiliary electrode based on the preset voltage step length until the absolute value of the difference value of the first voltage difference and the determined new second voltage difference is smaller than or equal to the preset threshold value.
Optionally, the continuous blood glucose monitoring device further comprises an analog-to-digital conversion unit and a switch, the analog-to-digital conversion unit is connected with the switch, the switch is provided with a channel connected with the working electrode and a channel connected with the auxiliary electrode, wherein,
Said detecting an actual voltage value of said working electrode and an actual voltage value of said auxiliary electrode, determining a second voltage difference, comprising:
Under the condition that a connecting channel of the switch and the working electrode is connected, acquiring an actual voltage value of the working electrode through the analog-to-digital conversion unit;
and under the condition that a connecting channel of the switch and the auxiliary electrode is connected, acquiring an actual voltage value of the auxiliary electrode through the analog-digital conversion unit.
Optionally, the continuous blood glucose monitoring device further comprises an extraction electrode, wherein,
In the case that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes:
obtaining current generated by electrochemical reaction based on the electrochemical reaction generated by the tissue fluid extracted by the extraction electrode in the electrochemical sensor;
determining the concentration of glucose in the tissue fluid based on the current generated by the electrochemical reaction.
According to a second aspect of the present invention, there is provided a continuous blood glucose monitoring device control apparatus comprising:
The device comprises a voltage loading module, a voltage detection module and a voltage detection module, wherein the voltage loading module is used for respectively loading corresponding bias voltages for a working electrode of an electrochemical sensor in continuous blood glucose monitoring equipment and an auxiliary electrode of the electrochemical sensor, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose;
The voltage detection module is used for detecting and obtaining the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
the voltage difference determining module is used for determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
And the adjusting module is used for adjusting the bias voltage loaded to the auxiliary electrode under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is larger than a preset threshold value so as to enable the absolute value of the difference value of the first voltage difference and the second voltage difference to be smaller than or equal to the preset threshold value.
According to a third aspect of the present invention there is provided a continuous blood glucose monitoring device control apparatus comprising a memory and a processor, the memory storing a computer program for controlling the processor to operate to perform the method according to any one of the first aspects.
According to a fourth aspect of the present invention there is provided a continuous blood glucose monitoring device comprising a control apparatus according to the second or third aspect, an AFE unit and an electrochemical sensor, wherein the control apparatus is connected to the AFE unit, three electrodes in the electrochemical sensor are each connected to the AFE unit, the three electrodes comprising a working electrode, a reference electrode and an auxiliary electrode.
Optionally, the device further comprises an analog-digital conversion unit and a switch, one end of the analog-digital conversion unit is connected with the control device, the other end of the analog-digital conversion unit is connected with the switch, the switch is provided with a channel connected with the working electrode and a channel connected with the auxiliary electrode, wherein,
The control device is also used for collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit under the condition that the connecting channel of the switch and the working electrode is connected;
and under the condition that a connecting channel of the switch and the auxiliary electrode is connected, acquiring an actual voltage value of the auxiliary electrode through the analog-digital conversion unit.
According to the control method provided by the embodiment of the invention, the actual voltage value of the working electrode and the actual voltage value voltage difference of the auxiliary electrode are accurately controlled, so that the voltage difference between the working electrode and the auxiliary electrode is suitable for the substance participating in electrochemical reaction in the electrochemical sensor to be glucose, other substances in tissue fluid are inhibited from participating in electrochemical reaction, and the accuracy and reliability of glucose concentration measurement in the tissue fluid are improved.
Features of the embodiments of the present specification and their advantages will become apparent from the following detailed description of exemplary embodiments of the present specification with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the specification and, together with the description, serve to explain the principles of the embodiments of the specification.
FIG. 1 is a flow chart of a method of controlling a continuous blood glucose monitoring device in accordance with one embodiment of the present invention.
Fig. 2 is a schematic block diagram of a continuous blood glucose monitoring device control apparatus in accordance with one embodiment of the present invention.
Fig. 3 is a schematic structural view of a continuous blood glucose monitoring device control apparatus according to an embodiment of the present invention.
Fig. 4 is a schematic structural view of a continuous blood glucose monitoring device according to one embodiment of the present invention.
Fig. 5 is a schematic structural view of a continuous blood glucose monitoring device according to one embodiment of the present invention.
Detailed Description
Various exemplary embodiments of the present specification will now be described in detail with reference to the accompanying drawings.
The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the disclosure, its application, or uses.
It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.
In one embodiment of the present invention, a continuous blood glucose monitoring device control method is provided. The method is applied to a continuous blood glucose monitoring device.
The continuous blood glucose monitoring device includes an electrochemical sensor. The electrochemical sensor has a three-electrode structure, namely a working electrode (WE, working Electrode), a reference electrode (RE, REFERENCE ELECTRODE) and an auxiliary electrode (CE, counter Electrode). Glucose in the tissue fluid can electrochemically react with a reactive enzyme in the electrochemical sensor to generate an electric current. And determining the concentration of glucose in the tissue fluid by a current value generated by electrochemical reaction of the electrochemical sensor.
According to fig. 1, the control method of the continuous blood glucose monitoring device of the present embodiment includes the following steps S110 to S140.
Step S110, corresponding bias voltages are respectively loaded to a working electrode of the electrochemical sensor and an auxiliary electrode of the electrochemical sensor, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose.
The bias voltage applied to the working electrode of the electrochemical sensor and the bias voltage applied to the auxiliary electrode of the electrochemical sensor are both pre-stored values, and can be obtained directly.
The bias voltage applied to the working electrode determines the severity of the electrochemical reaction of glucose at the electrochemical sensor. In this embodiment, the bias voltage applied to the working electrode is a voltage required to satisfy the electrochemical reaction of glucose in the electrochemical sensor.
The difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode determines the type of substance in the tissue fluid that participates in the electrochemical reaction. In this embodiment, the first voltage difference is a voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is only glucose, and the first voltage difference can inhibit other substances in the tissue fluid from participating in the electrochemical reaction.
Step S120, detecting and obtaining an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode.
The actual voltage value of the working electrode is different from the bias voltage applied to the working electrode due to the influence of the structure and the external environment, and the actual voltage value of the auxiliary electrode is different from the bias voltage applied to the auxiliary electrode. Therefore, it is necessary to detect the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.
In some embodiments, the continuous blood glucose monitoring device further comprises an analog-to-digital conversion unit and a switch, the analog-to-digital conversion unit being connected to the switch, the switch being provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode.
The step S120 specifically includes collecting, by the analog-to-digital conversion unit, an actual voltage value of the working electrode when the connection channel of the switch and the working electrode is turned on, and collecting, by the analog-to-digital conversion unit, an actual voltage value of the auxiliary electrode when the connection channel of the switch and the auxiliary electrode is turned on.
In the embodiment, the combination of the analog-digital conversion unit and the switch can realize the collection and the switching of the multichannel voltage signals, and the collection of the voltage values of the plurality of electrodes shares the same analog-digital conversion unit, so that the hardware complexity and the cost are reduced.
Step S130, determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.
In step S140, when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold, the bias voltage applied to the auxiliary electrode is adjusted such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.
In the case that the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold, determining that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is not suitable for glucose to participate in the electrochemical reaction may cause other substances in the tissue fluid to participate in the electrochemical reaction. In addition, since the bias voltage applied to the working electrode determines the intensity of the electrochemical reaction of glucose generated by the electrochemical sensor, in order not to affect the electrochemical reaction of glucose generated by the electrochemical sensor, after the corresponding bias voltage is applied to the working electrode, the bias voltage applied to the working electrode is not adjusted, but the bias voltage applied to the auxiliary electrode is adjusted, so that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is suitable for the glucose to participate in the electrochemical reaction.
Under the condition that the absolute value of the difference between the first voltage difference and the second voltage difference is smaller than or equal to a preset threshold value, determining that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is suitable for glucose to participate in electrochemical reaction, and simultaneously inhibiting other substances in tissue fluid from participating in electrochemical reaction.
In some embodiments, adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold value specifically includes adjusting the bias voltage applied to the auxiliary electrode higher if the second voltage difference is greater than the first voltage difference and adjusting the bias voltage applied to the auxiliary electrode lower if the second voltage difference is less than the first voltage difference.
Under the condition that the second voltage difference is larger than the first voltage difference, the bias voltage loaded to the auxiliary electrode is regulated, so that the detected actual voltage value of the auxiliary electrode is increased, and the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is reduced, so that the auxiliary electrode is suitable for glucose to participate in electrochemical reaction.
And under the condition that the second voltage difference is smaller than the first voltage difference, regulating down the bias voltage applied to the auxiliary electrode, so that the detected actual voltage value of the auxiliary electrode is smaller, and further, the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is larger, so that the auxiliary electrode is suitable for glucose to participate in electrochemical reaction.
In some embodiments, adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold value specifically includes adjusting the bias voltage applied to the auxiliary electrode based on a preset voltage step, re-detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, determining a new second voltage difference based on the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode, and continuing to adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than or equal to the preset threshold value until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold value.
And under the condition that the second voltage difference is larger than the first voltage difference, based on a preset voltage step, the bias voltage applied to the auxiliary electrode is increased, and the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode are detected again. And determining a new second voltage difference according to the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode. And under the condition that the absolute value of the difference value between the first voltage difference and the new second voltage difference is larger than a preset threshold value, continuously increasing the bias voltage applied to the auxiliary electrode based on the preset voltage step length until the absolute value of the difference value between the first voltage difference and the determined second voltage difference is smaller than or equal to the preset threshold value.
And under the condition that the second voltage difference is smaller than the first voltage difference, based on a preset voltage step, reducing the bias voltage applied to the auxiliary electrode, and re-detecting to obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode. And determining a new second voltage difference according to the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode. And under the condition that the absolute value of the difference value between the first voltage difference and the new second voltage difference is larger than a preset threshold value, continuously reducing the bias voltage applied to the auxiliary electrode based on the preset voltage step length until the absolute value of the difference value between the first voltage difference and the determined second voltage difference is smaller than or equal to the preset threshold value.
The bias voltage of the auxiliary electrode is adjusted step by step through the preset voltage step length, so that the potential difference between the working electrode and the auxiliary electrode can be accurately controlled, the problem of excessive adjustment in the voltage adjustment process can be avoided, and the stability of voltage adjustment is improved.
In some embodiments, the continuous blood glucose monitoring device further comprises an extraction electrode. In the case that the absolute value of the difference between the first voltage difference and the second voltage difference is smaller than or equal to a preset threshold value, the method further comprises the steps of obtaining current generated by electrochemical reaction based on the electrochemical reaction of tissue fluid extracted by the extraction electrode in the electrochemical sensor, and determining the concentration of glucose in the tissue fluid according to the current generated by the electrochemical reaction.
The continuous blood glucose monitoring device further comprises an AFE (Active Front End) unit. The working electrode, the reference electrode and the auxiliary electrode in the electrochemical sensor are all connected with the AFE unit.
Glucose in the tissue fluid extracted by the extraction electrode can electrochemically react with a reactive enzyme in the electrochemical sensor. Under the electrochemical action, a reference electrode RE and an auxiliary electrode CE in the electrochemical sensor are in short circuit to form an electrode RCE. The current generated by the electrochemical reaction of the electrochemical sensor flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit and flows in through the electrode RCE of the electrochemical sensor. Firstly, determining voltage values at two ends of a feedback resistor, and calculating current generated by electrochemical reaction of an electrochemical sensor according to the voltage values at two ends of the feedback resistor and the tissues of the feedback resistor.
According to the control method provided by the embodiment of the invention, the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode is accurately controlled, so that the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode is suitable for the substance participating in the electrochemical reaction in the electrochemical sensor to be glucose, other substances in tissue fluid are inhibited from participating in the electrochemical reaction, and the accuracy and reliability of the measurement of the glucose concentration in the tissue fluid are improved.
One embodiment of the present invention provides a continuous blood glucose monitoring device control apparatus. As shown in fig. 2, the continuous blood glucose monitoring device control apparatus 200 includes a voltage loading module 210, a voltage monitoring module 220, a voltage difference determining module 230, and an adjusting module 240.
The voltage loading module 210 is configured to load corresponding bias voltages to a working electrode of an electrochemical sensor and an auxiliary electrode of the electrochemical sensor in the continuous blood glucose monitoring device, where a voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in an electrochemical reaction in the electrochemical sensor is glucose.
The voltage detection module 220 is configured to detect and obtain an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode.
The voltage difference determining module 230 is configured to determine a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.
The adjustment module 240 is configured to adjust the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold.
In some embodiments, the bias voltage applied to the working electrode is a voltage required to satisfy the electrochemical reaction of glucose at the electrochemical sensor.
In some embodiments, the adjustment module 240 is further configured to adjust the bias voltage applied to the auxiliary electrode up if the second voltage difference is greater than the first voltage difference, and adjust the bias voltage applied to the auxiliary electrode down if the second voltage difference is less than the first voltage difference.
In some embodiments, the adjustment module 240 is further configured to adjust the bias voltage applied to the auxiliary electrode based on a preset voltage step, re-detect the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, determine a new second voltage difference according to the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode, and continuously adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.
In some embodiments, the continuous blood glucose monitoring device further comprises an analog-to-digital conversion unit and a switch, the analog-to-digital conversion unit being connected to the switch, the switch being provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode. The voltage detection module 220 is further configured to collect, by using the analog-to-digital conversion unit, an actual voltage value of the working electrode when the connection channel between the switch and the working electrode is turned on;
Under the condition that a connecting channel of the switch and the auxiliary electrode is connected, the actual voltage value of the auxiliary electrode is acquired through the analog-digital conversion unit.
In some embodiments, the continuous blood glucose monitoring device further comprises an extraction electrode. The device also includes a glucose concentration measurement module. The glucose concentration measurement module is used for obtaining current generated by electrochemical reaction based on the electrochemical reaction of tissue fluid extracted by the extraction electrode in the electrochemical sensor under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is smaller than or equal to a preset threshold value, and determining the concentration of glucose in the tissue fluid according to the current generated by the electrochemical reaction.
The continuous blood sugar monitoring device control device is an MCU (Microcontroller Unit, microcontroller).
One embodiment of the present invention provides a continuous blood glucose monitoring device control apparatus. As shown in fig. 3, continuous blood glucose monitoring device control apparatus 300 includes a memory 320 and a processor 310. The memory 320 stores a computer program for controlling the processor 310 to operate to perform the control method provided according to any of the above-described embodiments.
One embodiment of the present invention provides a continuous blood glucose monitoring device. According to the illustration of fig. 4, a continuous blood glucose monitoring device comprises a control means, an AFE unit and an electrochemical sensor as provided in any of the embodiments described above. The control device is connected with the AFE unit. Three electrodes in the electrochemical sensor are all connected with the AFE unit, and each three electrode comprises a working electrode, a reference electrode and an auxiliary electrode.
The control device loads corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor through the AFE unit.
The working electrode, the reference electrode and the auxiliary electrode in the electrochemical sensor are all connected with the AFE unit. Glucose in the tissue fluid extracted by the extraction electrode can electrochemically react with a reactive enzyme in the electrochemical sensor. Under the electrochemical action, a reference electrode RE and an auxiliary electrode CE in the electrochemical sensor are in short circuit to form an electrode RCE. The current generated by the electrochemical reaction of the electrochemical sensor flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit and flows in through the electrode RCE of the electrochemical sensor.
According to the illustration of fig. 5, the continuous blood glucose monitoring device further comprises an analog to digital conversion unit and a switch. One end of the analog-to-digital conversion unit is connected with the control device, the other end of the analog-to-digital conversion unit is connected with the switch, and the switch is provided with a channel connected with the working electrode and a channel connected with the auxiliary electrode.
The control device is also used for collecting the actual voltage value of the working electrode through the analog-digital conversion unit under the condition that the connecting channel of the switch and the working electrode is connected, and collecting the actual voltage value of the auxiliary electrode through the analog-digital conversion unit under the condition that the connecting channel of the switch and the auxiliary electrode is connected.
According to fig. 5, the control device is also connected to a switch. The control device controls the connection channel of the switch and the working electrode or the connection channel of the switch and the auxiliary electrode by controlling the level of the interface connected with the switch. For example, when the control device controls the level of the interface connected to the switch to be high, the control device controls the connection channel between the switch and the auxiliary electrode to be turned on, that is, the a-C channel to be turned on, and when the control device controls the level of the interface connected to the switch to be low, the control device controls the connection channel between the switch and the working electrode to be turned on, that is, the B-C channel to be turned on. Under the electrochemical action, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are shorted to form the electrode RCE, so that the actual voltage values corresponding to the reference electrode RE and the auxiliary electrode CE are the same voltage value.
The continuous blood glucose monitoring device further comprises a DC-DC unit and an extraction electrode, as described in FIG. 5. One end of the DC-DC unit is connected with the control device, and the other end of the DC-DC unit is connected with the extraction electrode. The control device is used for controlling the extraction electrode to extract tissue fluid through the DC-DC unit.
In this specification, each embodiment is described in a progressive manner, and identical and similar parts of each embodiment are all referred to each other, and each embodiment mainly describes differences from other embodiments.
The foregoing describes specific embodiments of the present disclosure. Other embodiments are within the scope of the following claims. In some cases, the actions or steps recited in the claims can be performed in a different order than in the embodiments and still achieve desirable results. In addition, the processes depicted in the accompanying figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.
Embodiments of the present description may be systems, methods, and/or computer program products. The computer program product may include a computer-readable storage medium having computer instructions for causing a processor to implement aspects of embodiments of the present description.
The computer readable storage medium may be a tangible device that can hold and store computer instructions for use by a computer instruction execution device. The computer readable storage medium may be, for example, but not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of the computer-readable storage medium include a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), a Static Random Access Memory (SRAM), a portable compact disc read-only memory (CD-ROM), a Digital Versatile Disc (DVD), a memory stick, a floppy disk, a mechanical encoding device, punch cards or intra-groove protrusion structures such as those having computer instructions stored thereon, and any suitable combination of the foregoing. Computer-readable storage media, as used herein, are not to be construed as transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through waveguides or other transmission media (e.g., optical pulses through fiber optic cables), or electrical signals transmitted through wires.
The computer instructions described herein may be downloaded from a computer readable storage medium to a respective computing/processing device or to an external computer or external storage device via a network, such as the internet, a local area network, a wide area network, and/or a wireless network. The network may include copper transmission cables, fiber optic transmissions, wireless transmissions, routers, firewalls, switches, gateway computers and/or edge servers. The network interface card or network interface in each computing/processing device receives computer instructions from the network and forwards the computer instructions for storage in a computer-readable storage medium in the respective computing/processing device.
The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present description. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of computer instructions, which comprises one or more executable computer instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions. It is well known to those skilled in the art that implementation by hardware, implementation by software, and implementation by a combination of software and hardware are all equivalent.
The embodiments of the present specification have been described above, and the above description is illustrative, not exhaustive, and not limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the improvement of technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (10)
1. A method of continuous blood glucose monitoring device control, wherein the continuous blood glucose monitoring device comprises an electrochemical sensor, the method comprising:
Respectively loading corresponding bias voltages for a working electrode of the electrochemical sensor and an auxiliary electrode of the electrochemical sensor, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose;
Detecting to obtain an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode;
Determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
And under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is larger than a preset threshold value, adjusting the bias voltage loaded to the auxiliary electrode so that the absolute value of the difference value of the first voltage difference and the second voltage difference is smaller than or equal to the preset threshold value.
2. The method of claim 1, wherein the bias voltage applied to the working electrode is a voltage required to satisfy an electrochemical reaction of glucose at the electrochemical sensor.
3. The method of claim 1, wherein adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold comprises:
increasing a bias voltage applied to the auxiliary electrode in the case that the second voltage difference is greater than the first voltage difference;
And reducing the bias voltage applied to the auxiliary electrode in the case that the second voltage difference is smaller than the first voltage difference.
4. The method of claim 1, wherein adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold comprises:
adjusting bias voltage loaded to the auxiliary electrode based on a preset voltage step length;
Re-detecting to obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
Determining a new second voltage difference according to the actual voltage value of the working electrode obtained through re-detection and the actual voltage value of the auxiliary electrode obtained through re-detection;
and under the condition that the absolute value of the difference value of the first voltage difference and the new second voltage difference is larger than a preset threshold value, continuously adjusting the bias voltage loaded to the auxiliary electrode based on the preset voltage step length until the absolute value of the difference value of the first voltage difference and the determined new second voltage difference is smaller than or equal to the preset threshold value.
5. The method of claim 1, wherein the continuous blood glucose monitoring device further comprises an analog to digital conversion unit and a switch, the analog to digital conversion unit being connected to the switch, the switch being provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein,
Said detecting an actual voltage value of said working electrode and an actual voltage value of said auxiliary electrode, determining a second voltage difference, comprising:
Under the condition that a connecting channel of the switch and the working electrode is connected, acquiring an actual voltage value of the working electrode through the analog-to-digital conversion unit;
and under the condition that a connecting channel of the switch and the auxiliary electrode is connected, acquiring an actual voltage value of the auxiliary electrode through the analog-digital conversion unit.
6. The method of any one of claims 1-5, wherein the continuous blood glucose monitoring device further comprises an extraction electrode, wherein,
In the case that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes:
obtaining current generated by electrochemical reaction based on the electrochemical reaction generated by the tissue fluid extracted by the extraction electrode in the electrochemical sensor;
determining the concentration of glucose in the tissue fluid based on the current generated by the electrochemical reaction.
7. A continuous blood glucose monitoring device control apparatus, comprising:
The device comprises a voltage loading module, a voltage detection module and a voltage detection module, wherein the voltage loading module is used for respectively loading corresponding bias voltages for a working electrode of an electrochemical sensor in continuous blood glucose monitoring equipment and an auxiliary electrode of the electrochemical sensor, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in electrochemical reaction in the electrochemical sensor is glucose;
The voltage detection module is used for detecting and obtaining the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
the voltage difference determining module is used for determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;
And the adjusting module is used for adjusting the bias voltage loaded to the auxiliary electrode under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is larger than a preset threshold value so as to enable the absolute value of the difference value of the first voltage difference and the second voltage difference to be smaller than or equal to the preset threshold value.
8. A continuous blood glucose monitoring device control apparatus comprising a memory and a processor, the memory storing a computer program for controlling the processor to operate to perform the method of any one of claims 1 to 6.
9. A continuous blood glucose monitoring device comprising a control device according to claim 7 or 8, an AFE unit and an electrochemical sensor, wherein the control device is connected to the AFE unit, three electrodes in the electrochemical sensor are connected to the AFE unit, and the three electrodes comprise a working electrode, a reference electrode and an auxiliary electrode.
10. The continuous blood glucose monitoring device of claim 9, further comprising an analog to digital conversion unit and a switch, wherein one end of the analog to digital conversion unit is connected to the control means, the other end of the analog to digital conversion unit is connected to the switch, the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein,
The control device is also used for collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit under the condition that the connecting channel of the switch and the working electrode is connected;
and under the condition that a connecting channel of the switch and the auxiliary electrode is connected, acquiring an actual voltage value of the auxiliary electrode through the analog-digital conversion unit.
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