[go: up one dir, main page]

CN1292798A - 用于治疗和诊断与胰岛素相关疾病的方法和组合物 - Google Patents

用于治疗和诊断与胰岛素相关疾病的方法和组合物 Download PDF

Info

Publication number
CN1292798A
CN1292798A CN 99803812 CN99803812A CN1292798A CN 1292798 A CN1292798 A CN 1292798A CN 99803812 CN99803812 CN 99803812 CN 99803812 A CN99803812 A CN 99803812A CN 1292798 A CN1292798 A CN 1292798A
Authority
CN
China
Prior art keywords
insulin
polypeptide
degrading enzyme
degradation
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 99803812
Other languages
English (en)
Chinese (zh)
Inventor
威廉·C·达克沃思
弗雷德里克·G·哈梅尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Frederick C Hamel
Original Assignee
Frederick C Hamel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frederick C Hamel filed Critical Frederick C Hamel
Publication of CN1292798A publication Critical patent/CN1292798A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN 99803812 1998-01-08 1999-01-08 用于治疗和诊断与胰岛素相关疾病的方法和组合物 Pending CN1292798A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7082198P 1998-01-08 1998-01-08
US60/070,821 1998-01-08

Publications (1)

Publication Number Publication Date
CN1292798A true CN1292798A (zh) 2001-04-25

Family

ID=22097585

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 99803812 Pending CN1292798A (zh) 1998-01-08 1999-01-08 用于治疗和诊断与胰岛素相关疾病的方法和组合物

Country Status (7)

Country Link
EP (1) EP1045860A2 (fr)
JP (1) JP2002500234A (fr)
CN (1) CN1292798A (fr)
AU (1) AU2313899A (fr)
BR (1) BR9906833A (fr)
CA (1) CA2317674A1 (fr)
WO (1) WO1999035169A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102369015A (zh) * 2009-02-02 2012-03-07 雷蒙特亚特特拉维夫大学有限公司 肽、包含该肽的药物组合物及其用途
US8901074B2 (en) 2010-08-04 2014-12-02 Ramot At Tel-Aviv University Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases
CN104961706A (zh) * 2015-07-06 2015-10-07 成都知普莱生物医药科技有限公司 一种合成胰岛素降解酶抑制剂ml345的方法
CN119322179A (zh) * 2024-09-03 2025-01-17 中日友好医院(中日友好临床医学研究所) 生物标志物在预测糖尿病强化治疗效果中的应用、试剂盒

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465714B2 (en) * 1999-11-05 2002-10-15 Arexis Ab Congenic animal models of non-insulin dependent diabetes mellitus
WO2006132530A2 (fr) * 2005-01-31 2006-12-14 Leiden University Medical Center Methodes et moyens a utiliser dans le diagnostic et le traitement de diabetes
WO2010049180A1 (fr) * 2008-10-31 2010-05-06 B.R.A.H.M.S. Ag Procédés et dosages pour la classification des denrées alimentaires et/ou des boissons et/ou des régimes alimentaires et/ou des traitements nutritionnels et/ou des médicaments, concernant leur effet sur le système cardio-vasculaire
CN115477686B (zh) * 2022-09-22 2024-01-30 北海黑珍珠海洋生物科技有限公司 一种具有美白功效的珍珠贝活性肽及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891435A (en) * 1993-04-16 1999-04-06 Research Corporation Technologies, Inc. Methods and compositions for delaying or preventing the onset of autoimmune disease
AUPM411994A0 (en) * 1994-02-25 1994-03-24 Deakin Research Limited Epitopes
US5594100A (en) * 1995-02-22 1997-01-14 Regents Of The University Of Colorado Epitope for prevention of type I diabetes

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102369015A (zh) * 2009-02-02 2012-03-07 雷蒙特亚特特拉维夫大学有限公司 肽、包含该肽的药物组合物及其用途
US8691760B2 (en) 2009-02-02 2014-04-08 Ramot At Tel-Aviv University Peptides, pharmaceutical compositions comprising same and uses thereof
US8901074B2 (en) 2010-08-04 2014-12-02 Ramot At Tel-Aviv University Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases
CN104961706A (zh) * 2015-07-06 2015-10-07 成都知普莱生物医药科技有限公司 一种合成胰岛素降解酶抑制剂ml345的方法
CN119322179A (zh) * 2024-09-03 2025-01-17 中日友好医院(中日友好临床医学研究所) 生物标志物在预测糖尿病强化治疗效果中的应用、试剂盒
CN119322179B (zh) * 2024-09-03 2025-11-11 中日友好医院(中日友好临床医学研究所) 生物标志物在预测糖尿病强化治疗效果中的应用、试剂盒

Also Published As

Publication number Publication date
CA2317674A1 (fr) 1999-07-15
EP1045860A2 (fr) 2000-10-25
AU2313899A (en) 1999-07-26
WO1999035169A2 (fr) 1999-07-15
WO1999035169A3 (fr) 1999-10-07
JP2002500234A (ja) 2002-01-08
BR9906833A (pt) 2001-11-27
WO1999035169A9 (fr) 1999-11-11

Similar Documents

Publication Publication Date Title
CN1268391C (zh) 外周给予的glp－1类似物和衍生物在控制肥胖中的用途
CN1191272C (zh) 亲脂组分和血管活性肠肽片段的缀合物
CN1188485A (zh) 胰高血糖素样肽-2及其治疗应用
CN1622941A (zh) 基于谷氨酰胺酰基的dpiv抑制剂
CN1568195A (zh) 用于治疗代谢性疾病的肽yy及肽yy激动剂
CN101057968A (zh) 用于预防或治疗体重过重的胃肠激素
CN1287789C (zh) 15－脂肪氧化酶抑制剂在制备减少骨损失的药物中的应用
CN1300220A (zh) 肽组合物和制剂及其使用
CN1164192A (zh) 多相催化蛋白酶的抑制剂
O'Harte et al. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
CN1491233A (zh) 长效生长激素释放因子衍生物
CN1886423A (zh) 脂联素的糖基同工型及其用途
CN1376166A (zh) 降低血液葡萄糖水平的肽
CN1362967A (zh) 含有D－氨基酸的β－淀粉样肽聚集的调节因子
CN1688696A (zh) Ghrh类似物
CN1870893A (zh) 胰岛素样生长因子－1(igf－1)缺陷的治疗方法
CN1678341A (zh) 促红细胞生成素的应用
CN1226290C (zh) 新颖的核受体配体
CN1292798A (zh) 用于治疗和诊断与胰岛素相关疾病的方法和组合物
CN1753662A (zh) 用于治疗β－淀粉状蛋白相关疾病的治疗制剂
CN1188164C (zh) 调节吞噬作用和icam－1表达的组合物和方法
HK1080363B (zh) 具有血管活性肠肽的生物学活性的化合物在治疗结节病中的用途
CN1125450A (zh) 因子vii衍生的肽
JP2008535797A (ja) ヒトレプチン由来のポリペプチドとその使用
CN1301269A (zh) 模板结合的npyy2受体激动剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1056682

Country of ref document: HK