CN1287861C

CN1287861C - 人源基因引导序列、基因载体及基因表达方法

Info

Publication number: CN1287861C
Application number: CNB018128734A
Authority: CN
Inventors: 夏家辉
Original assignee: Individual
Current assignee: Xia Jiahui
Priority date: 2000-07-17
Filing date: 2001-02-16
Publication date: 2006-12-06
Anticipated expiration: 2021-02-16
Also published as: US7247431B2; EP1304380A1; ATE466940T1; AU2001237201A1; EP1304380B1; JP2004508046A; DE60142052D1; JP4944349B2; EP1304380A4; WO2002020803A1; AU2000258017A1; CN1471581A; US20040137437A1; WO2002010375A1

Abstract

本发明涉及人源基因引导序列、基因载体及基因表达方法。它包括如下内容：(1)以人类D、G组染色体短臂上的无重要生理功能的DNA序列或与该DNA序列严格杂交的DNA序列作为基因的引导序列；(2)构建含有上述引导序列的基因载体；(3)以步骤(1)中提到的D、G组染色体上核仁组织区作为靶位，将目的基因导入人体细胞的D、G组染色体短臂的表达活跃的区域。本发明提供了一种全新的基因引导序列，由此构建的基因载体和基因表达方法。该基因表达方法可应用于人体基因治疗和制备蛋白质。

Description

人源基因引导序列、基因载体及基因表达方法

技术领域：

本发明涉及基因引导序列，用该基因引导序列构建的基因载体和利用该基因载体将目的基因导入人在体或离体细胞中进行基因表达的方法。

背景技术：

人类孟德尔遗传病数据库统计资料表明，到2000年6月30日止，已确定的单基因疾病有1660种，已克隆的疾病基因有989种，其中隐性遗传病大多可通过将正常基因导入患者细胞的方式进行基因治疗，随着研究的深入，显性遗传病及与体细胞突变相关的肿瘤也开始采用基因治疗的方法。虽然，美国学者E.Marshall 1995年曾在Science上提出新载体的研究和发现是研究基因治疗的核心问题，但5年后的今天，基因治疗的载体问题仍未得到解决，其主要原因是研究者未能跳出用病毒来源的元件构建载体的桎梏，而目前使用的病毒性载体普遍存在以下问题：(1)不稳定：由于基因插入效率不高，部分载体以附加体的形式存在于细胞核内，不能随细胞的分裂而稳定遗传，从而导致治疗基因不能长期稳定地表达；(2)安全性差：例如，随机插入所导致的插入突变可能影响插入位点的正常基因的功能或激活癌基因而引起其他疾病或肿瘤，另外病毒性载体还有可能产生具有复制能力的野生型重组病毒对机体造成更大的危害；近年来，在美国进行基因治疗的过程中已出现由于腺病毒载体而导致患者死亡的报道；(3)免疫原性：病毒基因产生的背景蛋白和病毒载体纯化过程中污染的蛋白都会引起机体的免疫反应，因而影响治疗基因的表达。

而80年代中期利用同源重组的原理发展起来的基因打靶载体虽能避免免疫原性和随机整合而达到定点导入的效果，但基因打靶载体用于基因治疗的定点修复或替换缺陷基因必需以基因两侧的特异性DNA片段做为引导序列，从而受到基因特异性的局限且导入效率很低，一般常应用于胚胎干细胞(ES)或受精卵细胞的基因剔除，不宜用于成熟体细胞的定点整合(Galli-TaliadorosLA，Sedgwick JD，Wood SA，et al.J Immunol Meth 1995，181：1-15；Hasty P，Rivera-Perez J，Chang C，et al.Mol Cell Biol 1991，11(9)：4509-4517)。因此，原美国人类基因学会主席、耶鲁大学医学院院长Leon.E.Rosenberg对基因治疗的现状做出的结论是—“在数百个基因治疗的实验中，至今还没有任何一例毫不含糊地具有临床疗效”(Rosenberg L E & Schechter A.N.Science，2000；287：1751)。

所以，寻找和开发一种能稳定遗传，对人体无任何危害，又便于体外操作的基因载体，仍然是基因治疗亟待解决的关键问题。

发明内容：

本申请人在1981年曾发现2个携带额外双随体小染色体(BM)而表型正常的家系，该小染色体分别在2个家系的2代人和3代人之间稳定遗传，且对人体无任何危害。当时查阅国际资料发现欧、美等国总计也有7个家系报导，至今已报导这类家系17个，但没有1人提出用该小染色体为原件组装人源性基因载体的构想。本发明人1991年提出了分离该小染色体原件、组装人源基因载体的设想，并于1994年立项，1995年计划开始具体实施。在研究中申请人用FISH技术查明，该小染色体来源于人的D、G组染色体短臂即13、14、15、21、22号染色体短臂，由于D、G组染色体短臂为核仁组织区，富含核糖体DNA(rDNA)，该区域不但在人群中存在着长度不同的各种多态(即含rDNA的量有多有少)，而且在细胞分裂间期该区域基因转录十分活跃，因此，本发明人推测如果能从BM克隆出具有特异性的DNA片段，并以其作为目的基因的引导序列，将目的基因定点导入人体D、G组染色体短臂核仁组织区，应该有较高的、稳定的和无害的表达。后续的实施例对此作出了有力的证明。

找到BM染色体并克隆出与D、G组染色体短臂核仁组织区同源的特异性DNA片段，具有十分重要的意义。

本发明人首先利用显微切割的方法，构建了小染色体特异性的pUC19文库并从中筛选得到单拷贝片段，该片段经荧光原位杂交(FISH)证实来源于小染色体和D、G组染色体短臂，进一步以此单拷贝片段为探针筛选人PAC基因组DNA文库，获得了约120kb的DNA片段(BMSF)，如序列表1所示，并经FISH证实来源于小染色体和D、G组染色体短臂(图1)。测序分析BMSF的序列特性，未发现与重要生理功能相关的基因，因此证明，以此为靶位点是安全的。

因此本申请人认为上述序列中基因引导序列选自人类D、G组染色体短臂上DNA序列作为目的基因的引导序列是符合发明目的的。例如基因引导序列选自序列表1表示的DNA序列。序列表1所描述的DNA序列是来源于人的。

根据本发明的实施例，申请人采用序列表1中从75590位到79448位，或与该序列严格杂交的序列为基因引导序列(GLS)构建载体。

按构建基因载体的要求可在基因载体中含有正负筛选基因。

更具体地，将序列表1中从75590位到79448位，长度为3.8kb的DNA片段为基因引导序列(GLS)装入pGEM-TK载体，利用TK做为负筛选基因，将正筛选基因Neo基因插入GLS中的1500位，使GLS分为1.5kb和2.3kb两臂，构建成基因载体，含基因载体的菌株已于2000年9月29日向中国典型培养物保藏中心提出保藏(中国.武汉武汉大学校内，邮政编码：430072)，其保藏号是：CCTCCM200030。保藏人对保藏物指定的分类命名为Escherichia coli JM109/JH-4/pNS2。如图2所示，其DNA序列描述见序列表2。

由于本发明提供的含有选自序列表1表示的DNA引导序列来源于D、G组染色体短臂特定的靶位，毫无疑问，由其构建的基因载体能将目的基因导入上述的特定靶位，并且由于该特定靶位的DNA片段不具有重要的生理功能相关的基因，因此目的基因的导入是安全的。

根据上述发明技术方案，本申请人进一步提出的外源基因表达方法，包括下列步骤：

(1)以序列表1中的75590位至79448位，或是与该序列严格杂交的序列为目的基因的引导序列，构建载体；

(2)将目的基因装入上述基因载体；

(3)将目的基因导入宿主细胞的D、G组染色体核仁组织区靶位；

(4)目的基因在体外或体内的细胞内表达。

上述步骤中构建基因载体，将目的基因装入基因载体，将目的基因导入宿主细胞以及实现目的基因的表达过程都可以通过现有技术来完成。

用上述基因引导序列可构建含有正负筛选基因的载体。

本发明实施例2、3说明了上述过程：①从约120kb的BMSF选择特异性较好的3.8kb DNA片段亚克隆入pGEM-TK质粒载体，以TK为负筛选基因，同时在3.8kb DNA片段中间插入正筛选基因Neo，构建成基因载体。②选择目的基因酶切后连入Neo基因一侧的外源基因克隆位点，经PCR测序证实各部分的存在及方向。③在pGEM载体上选择一单酶切位点将基因载体线性化，并利用电穿孔或脂质体转染的方法导入靶细胞。④用G418和GCV对转化的靶细胞进行正、负筛选，获得定点整合的阳性细胞克隆。⑤对阳性细胞克隆进行目的基因的表达检测，最终达到使目的基因定点整合到D、G组染色体短臂稳定表达的目的。

将筛选获得的表达目的基因阳性细胞通过皮下包埋或静脉注射等方式导入患者体内或将含目的基因的载体用脂质体包裹直接注入患者体内，使目的基因能在患者体内长期稳定表达，以纠正缺陷基因导致的临床症状。

本发明实施例中提供的基因载体的DNA序列如序列表2，其中引导序列为序列表1中的75590位至79448位，利用TK做为负筛选基因，将正筛选基因Neo基因插入GLS中的1500位，使GLS分为1.5kb和2.3kb两臂，构建成基因载体，目的基因的插入位点为5910位。本发明实施例中公开了目的基因治疗血栓性疾病的组织型纤溶酶原激活剂基因(TPA)在HT1080细胞内的体外表达，以及目的基因治疗血友病B的凝血因子IX基因(FIX)在HT1080细胞内的表达。

实验表明：其表达是有效和稳定的。

因此，本发明提供的基因表达方法，具有非常巨大的应用前景。不但可用于制备药用蛋白质，而且为基因治疗提供了有效的途径。

本发明人利用一种新的对人体无害的染色体为独特的材料，走出了一条全新的研究路线，该发现在国际上首次找到了人类D、G组染色体短臂核仁组织区是人类基因治疗与基因表达的最佳靶位点(13、14、15、21、22号染色体短臂核仁组织区的10个靶位点)，构建了一种能将目的基因定点导入这些靶位点的新载体—人源基因载体。

本发明与背景技术相比具有如下显著的优点：

1、稳定性好：按权利要求1或2所提供DNA序列作为基因引导序列来构建载体，能将目的基因定点插入到人体细胞的D组和G组染色体短臂上，并使目的基因随染色体而稳定遗传；

2、安全性好：由于在靶位点不含有与重要生理功能相关的基因，证明该靶位点安全，同时FISH证实载体能将目的基因定点插入细胞中安全的靶位点(图3，4)，排除了随机插入突变，也不存在野生型病毒的危害。目的基因在靶位点的表达是安全的。虽然本发明没有提供基因表达方法的临床证明，但申请人及国内外研究者发现的实例从另一角度证明了其安全性(实施例4)；

3、表达效率高：第一，由于本发明提供的基因载体含有来源于D、G组染色体短臂的引导序列，因此对应地在人体细胞中存在10个靶位点，插入效率比其它载体至少高5-10倍；第二，由于引导序列来自于基因转录活跃的D、G组染色体短臂，引导进入靶位点的目的基因能得到高效表达。

4、无免疫原性：由于该载体为人源性的，因此用于人体不会产生免疫原性。

图1是120kb PAC克隆DNA的FISH定位图；

图2是本发明提供的一种基因载体的结构图(基因载体序列全长：11162bp)；其中pGEM-7(8267-11162)：载体复制元件及原核筛选系统；TK(1-2840)：真核细胞负筛选基因，该基因使用TK启动子和TK polyA信号；Neo(4342-5910)：真核细胞正筛选基因，该基因使用sv40启动子和sv40polyA信号；GLS(2841-4341，5911-8267)：目的基因引导序列；Cloningsite(5910)：目的基因插入位点；

图3是外源性tPA基因在阳性细胞克隆中的FISH定位，证明该载体能将tPA定点导入D、G组染色体短臂；

图4是外源性FIX基因在阳性细胞克隆中的FISH定位，证明该载体能将tPA定点导入D、G组染色体短臂；

图5是TPA纯化产物Western结果，1～4为TPA纯化产物，“-”示阴性对照；

图6是FIX阳性细胞Western结果，F3～F23为6个不同阳性细胞株，“-”示阴性对照。

本发明提供的实施例只是实现本发明的一种方式，不能视为对本发明的限制。

实施例1

本发明提供的基因引导序列的制备：

1.基因引导序列PAC克隆的获得

1.1显微切割、PCR、微克隆构建BM特异性pUC19文库(Deng H-X，Yoshiura K，Dirks RW，et al.Hum Genet 1992，89：13.)

1.2BM特异性单拷贝DNA的获得及鉴定

(1)菌落点阵膜的制备：在两张尼龙膜上划好14×14个方格，标记为A、B，分别置于2个有固体LB的平皿中，从文库皿中随机挑取白色克隆分别点到两张膜坐标相同的方格内，共挑14×12个，第13行点100ng单拷贝DNA做阳性对照，第14行点100ng gDNA做为阴性对照，两个皿分别置37℃培养10～12小时，其中B膜置4℃保存，将A膜从皿中取出，分别在用以下溶液浸湿的滤纸上处理，10％SDS，5分钟，0.5N NaOH/1.5M NaCl，3分钟，1.5M NaCl/0.5MTris·HCl，3分钟，2×SSC/0.2M Tris·HCl，10分钟，80℃真空干燥2小时，37℃保存待用。

(2)gDNA探针的制备

取50～75ng gDNA加无菌水至11ml，100℃煮沸变性10分钟，以下列体系做随机引物标记反应：

2mM dNTP(dATP^-) 3μl

primer mixture 2μl

Klenow酶 1μl

α-³²P-dATP 3μl

点离混匀，37℃浮浴30分钟。加8μl stopmixture，过G-50柱纯化探针，取1/10测液闪值。

(3)杂交：菌落点阵膜置于2×SSC中浸泡10分钟，轻轻拭去膜表面的菌落碎片，65℃，5ml杂交液预杂交，30分钟以上。根据液闪值，按1.2×10⁶cpm/ml杂交液的量取探针液于100℃煮沸变性10分钟，加入5ml新鲜杂交液，与菌落点阵膜65℃杂交12小时以上。按以下条件洗膜：2×SSC/0.1％SDS，室温10分钟，2×SSC/0.1％SDS，65℃10分钟，0.1×SSC/0.1％SDS，65℃10分钟，-70℃放射自显影，杂交信号无或弱的初步认为是单拷贝。

(4)测序，Southern杂交鉴定：在B膜上相应位置挑取无杂交信号的克隆，小量扩增，抽提质粒DNA测序，与GenBank数据库比较，无相似性的为单拷贝。最后EcoRI酶切分离插入子DNA，并以随机引物法，用α-32P-dATP标记并与EcoRI消化的gDNA转移尼龙膜杂交，方法同上，1条或2条杂交带的为单拷贝。

1.3BM及D、G组染色体短臂特异性PAC克隆的获得及鉴定

(1)筛选人PACgDNA文库获得阳性克隆编号

利用α-32P-dATP随机引物法标记260bp的单拷贝探针P8-7→G-50柱(中等粒度)纯化→4℃待用→PAC膜7张用2×SSC浸泡10分钟→55℃预杂交3小时→探针100℃变性10分钟→以4.6×10⁵cpm/ml的量加入50ml购买的杂交液中，与PAC膜于65℃杂交1小时→洗膜：2×SSC，室温10分钟一次，2×SSC/0.1％SDS 65℃10分钟洗2次→上X光片，-70℃放射自显影12小时→冲洗X光片→按说明书方法读取阳性克隆编号。

(2)从5个不同的板上随机挑选阳性克隆编号，购买PAC克隆。

1.4PAC DNA与中期相细胞FISH杂交，证实来源于D、G组染色体短臂，如图1所示。

上述实验方法参见《分子克隆实验指南》J.萨姆布鲁克等，第2版，1989(J.Sambrook et al.Molecular Cloning.Second Edition.Cold Spring HarborLaboratory Press.1989)

2.基因引导序列DNA的获得

主要材料：β-agarose(Bio-Labs)NotI Agarose

①Not I酶切PAC169质粒；

②通过PFGE分离约120Kb大小的插入子DNA；

脉冲电泳条件：电极缓冲液：0.5×TBE、High stregth Analytical Grade Agarose：(Bio-Rad，Low Melting point Agarose LMP)1％、Switch Time：2秒→15秒电泳时间：18小时，电压：6V/cm，角度：120°温度：14℃

③电泳结束后，用EB染色(0.2μg/ml)30分钟，根据Marker指示，用无菌小刀片切下约120kb的条带。

④切下的胶块用β-agarase处理，乙醇沉淀。

实施例2

本发明提供的基因载体的制备：

1.基因载体的构建及目的基因的导入

1.1载体的构建

1.1.1用NsiI和StuI(平端酶)酶切PAC DNA，普通琼脂糖凝胶回收3.8kbDNA片段，电洗脱纯化；

1.1.2用HindIII酶切pGEM-TK载体DNA，Klenow酶补平，产生一平头末端；

1.1.3 pGEM-TK/HindIII补平产物进一步用NsiI酶切；

1.1.4 3.8kb/NsiI+StuI纯化产物与pGEM-TK/HK+NsiI酶切产物于16℃连接17小时；

1.1.5连接产物转化JM109感受态细菌，氨苄皿37℃培养18小时；

1.1.6随机挑取单克隆，用NsiI及NheI双酶切鉴定阳性克隆。

1.1.7用XbaI和NheI双酶切pCDN-GPR质粒获得Neo/XbaI+NheI

1.1.8将Neo/XbaI+NheI与pGEM-TK-3.8kb/NheI连接，构建成pNS2基因载体。

2.1TPA/FIX的导入

2.1.1将TPA/FIX(CDS)克隆至pcDNA 3.1(-)；

2.1.2设计引物TPCF和TPCR扩增TPA/FIX基因及表达元件(CMV启动子和BGH poly A信号)，使其两端装上AvrII酶切位点；引物序列为：

TpcF：ATgCAT CCTAggggAggTCgCTgAgTAgTg

AvrII

TpcR：TgCAT gCCTAggTACCCCCTAgAgCCCAg

AvrII

2.1.3用AvrII酶切TPA/FIX基因及表达元件(CMV启动子和BGH poly A信号)并与NheI酶切的pNS2载体连接。

上述实验方法详见《分子克隆实验指南》J.萨姆布鲁克等，第2版，1989(J.Sambrook et al.Molecular Cloning.Second Edition.Cold Spring HarborLaboratory Press.1989)

2.基因载体DNA的抽提

2.1材料：

2.1.1 QIAGE Plasmid Maxi Kit

2.1.2培养基：液体LB

Trypton 5g

Yeast extract 2.5g

Nacl 2.5g

ddH2O 定量至500ml

高压蒸汽灭菌

2.1.3氨苄青霉素(Amp)：100mg/ml(1000×)

2.2方法：

1)挑取阳性单克隆至3ml LB(Amp+)37℃，250rpm培养1小时

2)取100μl上述初级培养物置100ml LB(Amp+)中，37℃，250rpm培养16小时

3)于4℃，6000g离心15分钟收获细菌

4)10ml Buffer P1重悬菌体

5)加入10ml Buffer P2，轻柔地倒转6次混匀，室温5分钟。

6)加入10ml冰上预冷Buffer P3，轻柔倒转6次混匀，冰上20分钟。

7)4℃，20000g离心30分钟。

8)迅速将上清转移至另一40ml高速离心管，4℃，20000xg再次离心15分钟

9)10ml Buffer QBT平衡QIGEN tip 500

10)将上清转移至QIGAE tip 500过柱

11)2×30ml Buffer QC洗柱

12)15ml Buffer QF洗脱，收集洗脱液

13)洗脱液加(0.7倍体积)10.7ml异丙醇，混匀

14)15000g，4℃，离心30分钟

15)去上清，DNA沉淀加入5ml 70％乙醇洗涤，15000g，4℃离心10分钟

16)去70％乙醇，空气中干燥10分钟适量TE溶解DNA沉淀

实施例3

利用实施例2得到的带有目的基因TPA和FIX的基因载体，分别在宿主细胞中导入目的基因，并在体外细胞中表达。

1.材料：

1.1细胞：HT1080

培养基：高糖DMEM+10％FBS(HT1080)EMEM+10％FBS

1.2电穿孔仪：Bio-Rad公司

2.方法：

1)细胞于75cm²培养瓶内传代后长至70％～80％满底

2)收获细胞，用HeBs缓冲液洗2次，计数细胞

3)15000rpm，4℃离心10分钟

4)适量HeBS重悬，使细胞浓度为10⁶～10⁷/ml

5)取0.4ml电击杯，每杯加细胞悬液0.8ml，载体DNA 10μg左右

6)用电穿孔仪进行电击，电击条件设定为电压260V，电容550μF，电击时间一般为11～13毫秒。

7)电击细胞转入75cm²培养瓶中，加14ml含双抗的培养基，37℃，5％CO2中培养，24～48小时。

8)培养基内加入终浓度300μl的G418进行筛选，2～3天换液一次，换液时重新加G418，同时用正常细胞做对照

9)约7～10天后正常细胞全部死亡，计数转染细胞内存活克隆数，改用维持量G418 150μg/ml

10)转染细胞继续用终浓度为500ng/ml的GCV进行筛选

11)7～10天大部分克隆死亡，剩余存活细胞改用维持量GCV 250μg/ml或不加经过筛的细胞长至70～80％满底后，测定转移基因的表达活性。

3.结果

利用该载体将TPA基因和FIX基因用电穿孔的方法分别导入HT1080细胞，经正、负筛选得到阳性细胞株，FISH证实为定点插入(图3、图4)。TPA活性测定结果详见表1。

HT1080细胞阴性对照TPA活性为0U/10⁶细胞/24小时，导入后TPA活性为408 U/10⁶细胞/24小时，转化后95天表达量为407，表达十分稳定，见表1。FIX活性也由阴性对照的低于0.5μg/ml升高到2.5μg/ml，而且转化109天表达量仍为2.6μg/ml，见表2。二者的表达产物均已通过Western杂交证实(图5、图6)。TPA表达产物现已得到纯化。

表1 TPA转化的阳性细胞TPA活性测定

转化后	T1	转化后	T15
转化后	T1	转化后	T15	33天	408	54天	188

37天60天68天74天88天90天95天

396411430430441440.9407

58天95天

204114

(T1、T15为两个tPA阳性细胞株)

表2.FIX活性测定：(ug/10⁶细胞/24小时)

转化后天数	克隆F23
转化后天数	克隆F23	60天72天100天109天	2.52.42.92.6

实施例4

在人群中存在的安全性实例：

从1973年夏家辉从事人类与医学细胞遗传学研究以来，所发现和鉴定的来自全国189个实验室的470位临床细胞遗传学工作者所申报的732种世界首报核型中，有41种核型涉及D、G组染色体短臂，但不论易位到D、G染色体短臂的片段来源于1-22号哪一号染色体，或源于同一号染色体的片段长短各异，所含基因从1个到上千个，而携带者本人的表型都是正常的，说明易位到D、G染色体短臂的基因能正常表达，据此，我们将D、G组染色体短臂作为基因治疗的靶位点应该是安全的。

1、核型：46，XX，t(1；12；22；15；11；8)(1qter→1p11::8p23→8pter；12pter→12q11::1p11→1pter；22qter→22p11::12q11→12qter；15pter→15q15::22p11→22pter；11pter→11q21::15q15→15qter；8qter→8p23::11q21→11qter).

表型：女，28岁，为表型正常的携带者

资料提供者：吴素彬，广东省广州市，中山医科大学附→院妇产科细胞遗传室，邮政编码：510080

2、核型：46，XY，t(1；13)(1pter→1q32::13p11→13pter；13qter→13p11::1q32→1qter).

表型：女，24岁，为表型正常的携带者

资料提供者：肖晟，哈尔滨医科大学生物教研室，邮政编码：150086

3、核型：46，XX，t(2；15)(2pter→cen→15qter；2qter→cen→15pter).

表型：女，26岁，为表型正常的携带者

资料提供者：郭裕萍等，江西省南昌市，江西省妇产科医院细胞遗传室，邮政编码：330006

4、核型：46，XY，t(2；21)(2pter→cen→21pter；2qter→cen→21qter).

表型：男，32岁，为表型正常的携带者

资料提供者：康过秦等，山西省太原市，山西医学院附二院遗传研究室，邮政编码：030001

5、核型：46，XY，t(3；22)(3qter→cen→22pter；3pter→cen→22pter).

表型：男，26岁，为表型正常的携带者

资料提供者：高永，山东省滨州市医学院毒理室，邮政编码：256603

6、核型：46，XY，t(3；22)(3pter→cen→22qter；3qter→cen→22pter).

表型：男，29岁，为表型正常的携带者

资料提供者：石化金等，辽宁锦州市妇婴医院遗传室，邮政编码：121000

7、核型：46，XX，t(4；15)(4qter→4p13::15p13→15pter；15qter→15p13::4p13→4pter).

表型：女，28岁，为表型正常的携带者

资料提供者：周玲等，湖北省武汉市，武汉市儿童医院遗传实验室，邮政编码：430016

8、核型：46，XY，t(4；21)(4qter→4p15::21p11→21pter；21qter→21p11::4p15→4pter).

表型：男，25岁，为表型正常的携带者

资料提供者：徐竞芳等，上海市第六人民医院遗传室，邮政编码：200000

9、核型：46，XY，t(4；14)(4pter→4q31::14p11→14pter：14qter→14p11::4q31→4qter).

表型：男，为表型正常的携带者

资料提供者：周明君等，河志省许昌市中心医院，邮政编码：16100010、核型：46，XY，t(4；14)(4pter→4q35::14p11→14pter；14qter→14p11::4q35→4qter).

表型：男，27岁，为表型正常的携带者

资料提供者：张秀泉等，广东省佛山市，佛山市妇幼保健院，邮政编码：528000

11、核型：46，XX，t(5；22)(5pter→5q13::22p11→22pter；22qter→22p11::5q13→5qter).

表型：女，32岁，为表型正常的携带者

资料提供者：曹建萍，河南安阳市妇幼保健院遗传室，邮政编码：455000

12、核型：46，XY，t(6；22)(6pter→cen6→22qter；6qter→cen22→22pter)

表型：男，25岁，为表型正常的携带者

资料提供者：祝新霞等，山东省泰安市，山东泰安第88医院妇产科细胞遗传室，邮政编码：271000

13、核型：46，XY，t(6；22)(6qter→6p21::22p11.2→22pter；22qter→22p11.2::6p21→6pter).

表型：男，33岁，为表型正常的携带者

资料提供者：杨兰青，山东省滨州市滨州医学院附属医院妇产科，邮政编码：256603

14、核型：45，XX，t(7；21)(7qter→7p22::21p12→21qter).

表型：女，23岁，为表型正常的携带者

资料提供者：孙吉庆等，湖北省武汉市，湖北省武汉市儿童医院医学遗传实验室，邮政编码：430016

15、核型：46，XY/46，XY，t(7；14)(7pter→7q11::14p11→14pter；14qter→14p11::7q11→7qter)

表型：男，28岁，为表型正常的携带者

资料提供者：李麓芸、夏家辉等，湖南省长沙市，湖南医科大学医学遗传学研究室，邮政编码：410078

16、核型：46，XY，t(8；14)(8qter→8p21::14p12→14pter；14qter→14p12::8p21→8pter)

表型：男，27岁，为表型正常的携带者

17、核型：46，XY，t(9；14)(9pter→cen→14pter；9qter→cen→14qter)

表型：男，28岁，为表型正常的携带者

资料提供者：程秋云等，衡阳医学院附一生殖医学研究室，邮政编码：421001

18、核型：46，XX，t(9；22)(9pter→9p13::22p12→22pter；22qter→22p12::9p13→9pter)mat

表型：女，31岁，其母、1妹、1弟、1子具有相同核型，同为表型正常的携带者

资料提供者：李麓芸，夏家辉等，湖南医科大学医学遗传学研究室，邮政编码：410078

19、核型：46，XX，t(9；14)(9pter→9q12::14p12→14pter；14qter→14p12::9q12→9qter)

表型：女，32岁，为表型正常的携带者

资料提供者：孙艳阳等，黑龙江省哈尔滨市，哈尔滨医科大学生物教研室，邮政编码：150086

20、核型：46，XX，t(9；15)(9pter→9q21::15p12→15pter；15qter→15p12::9q21→9qter)mat.

表型：女，36岁，为表型正常的携带者

资料提供者：朱桂珍等，山东省泰安市，山东泰安第88医院妇产科细胞遗传室，邮政编码：271000

21、核型：46，XX，t(10；13)(10pter→10q24::13p11→13pter；13qter→13p11::10q24→10qter).

表型：女，28岁，为表型正常的携带者

资料提供者：严敦清，青岛医学院附属医院妇产科研究室，邮政编码：266003

22、核型：46，XX，t(10；13)(10pter→10q24::13p12→13pter；13qter→13p12::10q24→10qter).

表型：女，29岁，为表型正常的携带者

资料提供者：张影如等，广东省广州市，中山医科大学附一院神经科，邮政编码：510080

23、核型：46，XX，t(11；14)(11pter→cen→14pter；11qter→cen→14qter)

表型：女，2岁，为表型正常的携带者

资料提供者：王志勇，河南省柘城县，柘城县人民医院遗传室，邮政编码：476200

24、核型：46，XX，t(11；21)(11pter→11p11::21p11→21pter；21qter→21p11::11p11→11pter).

表型：女，26岁，为表型正常的携带者

资料提供者：郑军等，陕西省西安市，陕西省妇幼保健院医学遗传实验室，邮政编码：710003

25、核型：46，XY，t(11；15)(11pter→11q13::15p12→15pter；15qter→15p12::11q13→11qter)

表型：男，23岁，为表型正常的携带者

资料提供者：杨瑞芳等，山东医科大学附属医院围产医学中心，邮政编码：250012

26、核型：46，XX，t(12；14)(12pter→cen→14pter；12qter→cen→14qter)

表型：女，28岁，为表型正常的携带者

资料提供者：韩维田等，辽宁省计划生育科研所优生研究室，邮政编码：110031

27、核型：46，XX，t(13；16)(13qter→13p11::16p11.2→16pter；16qter→16p11.2::13p11→13pter).

表型：女，27岁，为表型正常的携带者

资料提供者：安松兰，辽宁省大连市，大连市妇产医院遗传室，邮政编码：110078

28、核型：46，XY/45，XY，t(13；13)(13qter→13p12::13p12→13qter).

表型：男，39岁，为表型正常的携带者

29、核型：46，XY，t(14；18)(14pter→cen→18pter；14qter→cen→18qter)

表型：男，30岁，为表型正常的携带者

资料提供者：王素桂等，北京市计划生育技术指导所，邮政编码：100006

30、核型：46，XX，t(14；15)(14pter→14q13::15p13→15pter；15qter→15p13::14q13→14qter)

表型：女，28岁，为表型正常的携带者

资料提供者：李麓芸，夏家辉等，湖南省长沙市，湖南医科大学医学遗传学研究室，邮政编码：410078

31、核型：45，XX，t(15qter→cen→22qter).

表型：女，27岁，为表型正常的携带者

资料提供者：夏家辉等，湖南医科大学医学遗传学国家重点实验室，邮政编码：410078

32、核型：46，XY，t(15；18)(15pter→cen→18pter；15qter→cen→18qter).

表型：男，30岁，为表型正常的携带者

资料提供者：任国庆等，北京市计划生育技术指导所，邮政编码：100006

33、核型：46，XX，t(15；20)(15pter→cen→2pter；15qter→cen→2qter)

表型：女，26岁，为表型正常的携带者

资料提供者：王新等，湖南医科大学附二医院妇产科遗传室，邮政编码：410011

34、核型：46，XX，t(15；22)(15pter→15q11::22p13→22pter；22qter→22p13::15q11→15qter)。

表型：女，27岁，为表型正常的携带者

资料提供者：符生苗，海南省海口市，海南省人民医院遗传室，邮政编码：570011

35、核型：46，XX，t(15；22)(15pter→15q22::22p11→22pter；22qter→22p11::15q22→qter)

表型：女，29岁，为表型正常的携带者

资料提供者：李牧尧等，新疆乌鲁木齐，新疆医学院医学遗传室，邮政编码：830054

36、核型：46，XY，t(16；21)(16pter→16q21::21p11→21pter；21qter→21p11::16q12→16qter).

表型：男，29岁，为表型正常的携带者

资料提供者：张惠芳等，广东省计划生育科学技术研究所，邮政编码：510080

37、核型：46，XX，t(18；21)(18qter→cen→21qter；18pter→cen→21pter)

表型：女，为表型正常的携带者

38、核型：46，XX，t(18；21)(18pter→18q11::21p12→21pter；21qter→21p12::18q11→18qter)

表型：女，26岁，为表型正常的携带者

资料提供者：李修林等，辽宁省沈阳市，中国医科大学附一院小儿科遗传室，邮政编码：110001

39、核型：45，X，dic(Y；13)(Ypter→Yq1200::13p11→cen→13qter)

表型：男，4岁，为表型正常的携带者

资料提供者：夏家辉等，湖南医科大学医学遗传学国家重点实验室，邮政编码：41007

40、核型：46，XY，t(Y；15)(15qter→15p12::Yq12→Ypter)pat.

表型：男，新生儿，为表型正常的携带者

41、核型：45，X，psu dic(Y；22)(Ypter→Yq1209::22p12→cen→22qter)

表型：男，为表型正常的携带者

资料提供者：刘希贤等，湖北武汉同济医科大学医学遗传学研究室，邮政编码：430030

上述染色体异常携带者均未发现任何异常体征，说明在核仁组织区不但可接受外源基因，而且能让外源基因正常表达。

<110>Xia Jiahui

<120>Gene leading sequence，gene vector，gene targeting site and gene

expression strategy

<160>2

<210>1

<211>～120kb

<212>DNA

<213>Homo sapiens

<400>PAC clone sequence

1 TATTTGTATG TATCCTGGAA TACACAGAAT AAGATCTTGC ATGTAAGAAA

51 CATTTTAATA GTTTTTAATG TGAATCAACA AACAGGTAAA TGGGCTTTTT

101 TATAATAGAA TGTTACAGGT AACATAATAT GCATGACATA TCTAATAATT

151 AAATCTATTA AATTTCTTGA GTGTTGAATT TATCTTTTCT TCTAATGTTG

201 AGAATGTATA AGTTGAGGTG ACATGTTGAG AAAATATGTC ATATAGAAGA

251 AAATAAAATT TAGAAAAGAT GAAAAGGAAA TAGGAAAGGT GGATACAGCC

301 TGTTTTCTAA TATCTTCCAA CTGGAAGCTT AGATTAGGAT TTTAGATTAA

351 ATTTTCTTAA ATTTTTAAAG ACCCAATCAT TTTCTATTAA ATACCTGTTT

401 TTCAGGACAT ACATTACTCT TTCAAATTCT GAATAAAAAT TCTTTCTCCA

451 GCTGTTAAGT TGCTGGAATT TTTTTTCCCT CTCTCTGTAG TAAGAATGTT

501 TCAACTTTCA GATCAATCAT CATGGTTAAC TCTTGGGATG TGTTATTTTA

551 TAGTAAACAA ATGAAACTCT TTCTTACATA AGTATTTACA CAAAACAAAT

601 TGTCGAGTAA ATGCTAACCA GTATTATTAA GCATATATTA TGAACACAAG

651 GTTTTCTTTT AAGCTCATAT TTGATTGACT GGTCATGTCT CTTTTTTTGT

701 TTGTTTCTCC CTCCTTCCCC TTTGTTTAAA AATGATTTAC CTCAGTCTAA

751 CTTTCTCCTT GCAGCCCACA TGTCCTTAGT GTCTATTCTT TCATTTCACT

801 TCTGTTTCTA TTGTCAGCAT ACTTAGTTAC AGCTTTCTAT TTAGTAGCTA

851 TGTGTGGCCT TCATTCATGA ATCATTGCTC CGTAAGGTGG ATGGTTGCTT

901 TGTTCTGTCT TTTTTGGAAG GAGCTTAAGT TATACTATAA TTTGTTTTTA

951 GCTTTTGACA CACTGAATAG AAGCAACTTG TACTGTTTCT GATGCCAACC

1001 CATTTAAATA TAGTACTACT AAAAACTACA TTCTCACATT TTTTCCCACA

1051 AAATGCAATT TGTACAAATA TACATCATGC ATAGCTATTT TGAAAAATAA

1101 TGTGATTAAT TTACTTTTTT ATTATTAGTT TTATTCGGTA ATACTCTAAA

1151 CTACATAGGG TACATTTTTG TTCTAGTTTG TTGTGGTTAA TAAAAGAAAC

1201 TAATGGATAT CATAGTATTT GTATAATAAT CAACTGGGGT TGAAAGGAGT

1251 AACATTTTGA AAATATCTGT CTCACCAATC ATAACCATCA TGCCATGTGA

1301 ATCTGTAGAT AAGTAAATGG CAGACTTGAG GTTTGAATCT ACATATGAGT

1351 GACTTCAACG TCCATACTTT TCCTGTTAGA TCATGTTGTA ATGGTGGGTA

1401 TTATCATTAT TTTAACTTGC CCCATGTTAT TCTTAAACCT ATTGTGTTTT

1451 TCTTCTAGAC TATTTCAAAA CTATACATCC CAGAGAGAAG GATTATTTCT

1501 CTATGATCGA TAGAAGATGG TAAGCTATTT GAAGCCTGCC TATTGCAGTA

1551 TTTACTGATT CTTCATTTGT TTTTTGTTTT TTTTTTCTTT TTTAAACACA

1601 GTCTTACTAG TCTGCAGCCC AGGCTGGAGT GCAGTGGTGC GATCTTGGGT

1651 CACTGCAGCT TCCACCTCTT GGGTTCAAGT GATTCTCCTG CCTCAGCCTC

1701 CCAACTAGCT GAGATTACAG GTGCGCACCA CCACACCTGG CTAATTTTTG

1751 TATTTTTAGT AGAGATGGAG TTTCACAATG TTGTCCAGGC TGGTCTCAAA

1801 CTTTTGACCT CAAGTGATTC CCCCGCCTAG GCCTCCCAAA CTGCTAGGAT

1851 TACAGGCGTG ACCCACCACA CCAGGCCTTG TGGATTATTA TTATTATTTT

1901 TATAAGGATA GAGTCTTGCT ATTTTGCCCA GGCTGGTCTC AAACTCCTGG

1951 GCTTCTCAAG TTATACTTCT GCCTCAGCCT TCTGAGTAGC TGGAATTATA

2001 GGAACAAGAC ACTGTGTTCT TTTATGTTTT TAGTACTCTG TAGTTTTCTA

2051 TTGTTGATTT AAAATGCATT TTACTTTTTC TTTCATAGTG CTTCCTCCTG

2101 TTGAAGAGTG TTTTGACAGG TATGATTTCA CAGATTTTTT AAAGTGATAT

2151 GTTAACTAAG TGAATAGAGA GAATAGAAAC TAGTATCTGT TTAGTGTTCT

2201 ACTCTGTGCT AGACACCATA TTACATGCTT AACATTTATC ATGTCATGTC

2251 ATCTTCACAC GCTTTACAAA CTATTTGTGC TATTATTGCT TTTTTACTAA

2301 TAATAGGCAA CTCTGCTTTA AAGAGGTTGA AATATTGGCT CATGATTCCA

2351 CAGTTAACAG GTAGCCAACC CAAGATTAGA CCATCATCCT GCCTGGCTCT

2401 CAAATCACTT CATTTGCCCC TAAGCATAGA TGGATAGAGG CCTATGCAGC

2451 AATGGGATCA CGGTACTGAT TTACATCGGA TCAATTCAGA AAGTCACATT

2501 TTGTTATATA TTAACTGTCT TTAGAGTGTT ATTTAGAAGC CTGGCTACTC

2551 CAAAAGTTTG TCCAAATATT TTGAAATGGC AGTGGTAACC ATATTACTTT

2601 TTTTTTTAAT CATCAAAGTT TTAAAGGCAG TTATCAGTTA TCTGTGGCCA

2651 CAGGACCCTA AGTTTTTCAT AAGCAAGACC AGGCCAGTCC TAGAAAAATA

2701 TTATCTTACT GTGCTTGGAG AATATCTAAA TATAGTCCAT GTTATGTTAA

2751 CTATATTTAG CATATATTAA AAGGATATTT CTAATTCATT TCTCTACTTA

2801 CTACCTACCC AGTTAGGTTT TCTCTTTCAG TAAGTACCCT GCCTGGTTCT

2851 CTGAAGCTTT TTCTTATTTT CTGGATTCTT TTTTTTCCTT CTGTGACATT

2901 TTAATAATAT TTTCTTGATT TCTTTTTACT TTCTCCTCTG CTTTTCTTAG

2951 GGTTTATGAT CTTCTATTAT AGTTTTCATT TAAGGCAGCT AAATATTCCC

3001 CATTTTCCTA TAGACAAAAT CAGAGGTGCA TAGAATTTCA GAATATTAAG

3051 AAATCCTAGA GACTAAACAA AATATCTTCT AGTACTTGAA TCCTTGCTTA

3101 ACATCCTGAT CAAGTGGTTG TTCAGGTGGA GAACCTGAAA CTCAAAGAGA

3151 GAAAATTATT TGGATACAGT AAATCAGAGA AATGAGAATT GCACTCAGGT

3201 TTCTTAGTTC AAAACCCAGT CTTCTTTTAC ATCATTCTGT CATTGAGTGA

3251 TTTTAGTTTT AGAAAGAGGG AGTGGCTCTG GTGAACACAG TGGAAAAGGA

3301 TGAGAATGGA ATGAGCTGTT GAACCCAATG AAAGTGGATA AGAATGGAAT

3351 TTGCAGGGGA CAGACAAATT TGAAGATGTA GATTGGAGAT TGTCATTGAT

3401 CCCTGCAGAA GAGGGATCCA GAAGGGGGAG CCCATAGGAA GGTATTTAGA

3451 TAGTGATGAA TGAAATGAAG CTGTAAGTAC TCAGGAGGGA GACTTTTCCA

3501 GCAGTCTCTC TCTTGAGTAT CTGAGTGTTT ATGAAGGTTC TTAAGCTTGC

3551 TGGTTTTTGT GGACCTGAAT AAGGCAGGAT CTATATAGTG ACAATAATTG

3601 GATTTTATAA TTTTTAATGT TTTAATCTTC TGTGAGGAAT ATTCCCAGAG

3651 TACATTTGTA CTTTGACTTT TTTACACTCA GCTTTCAAAC ACTTGCAGTG

3701 TTTCAGGGGG CTCCCTGTAG AGTTCTAGAG TAAAGAGAAT CAATGGGCAA

3751 TCTAAGTAGC TTACATGCTG AAGATCCAAG ACTCCCATTT TCCAGTGACA

3801 CAGATTAGTC TTTGAATCAG AAATAGATAA TGCAGAAGAC ACAGTGCCTT

3851 TTCTACCTTG TTTTAGGTTA TCGGGTTTAC TGCAGTTGAG TAACAAAAGT

3901 TGTTTCAGAT ATCAATTGGA TTTTCAGTTT AGTCTTTAGG GTAGATAATT

3951 TATAAAGACA TATTATTGTC TGGCCGTGCC ATTGTAATGC CTGTCACTAT

4001 CTGTTACGGG TTTAAGGGTG AGTCTGCATT GGATATTTCA TAGGTTGGGA

4051 GAGGTGGAGG CAGAAATAGG TAACTGAAAT GTTTTCTAAA ACGGAAGCCA

4101 TATCTTAATT ATACCAAGAA ATATTATTTA ATATAAGGAT AACTGACCTT

4151 CCTCAGACTT TGTTTTACCA TTTTTTTGTG GAGGGGACAT GCATGTATAG

4201 ACTGATGGTT TTTGTTTTCT TTTAAGAAAC GAACGTGCTC ATTTTTGTCA

4251 TATCTTTTTG CTCTGTAGGT GTCGCTACCT ACTGGATAGT GTTGCACAGC

4301 CTGTGACAAA GGATAAGTTT GCTTTGGAAT CTGAAGTAGA GTACTGTCTC

4351 GTGAAATTAA TTTTCTCATT CTGAATCTCA TTTTTTGTAT TATTTTCTTC

4401 TAAAACTTAG CGATTGTCTA CCTATCATTG TTTTATGTTA GTATTAAAAC

4451 TTTTATTAGA GATAACCATT TTAAAGAAAT AGGAGGGCTT AATTTTAATT

4501 TTTTTTTTCA CTTTGCAAAT AAGAAATAGT TGATAAATAC GTTGAGAGGT

4551 GTGATCTGAA AAAAAAAAAA TACATAGTGA CAGAAAAATG TTGTTTGGGA

4601 ACGCTTTCCC ACAAGAGAGG AGATACAAAT TTTGATCTAG GCTTATCTCA

4651 GTAAGTGTTT TTACTTTGAG TTGTATATCA TATGAGTATG ACTAATAATA

4701 CCTCTGTTTA ACTGAATGTT TGTTACATCA GATGACTTAT TATGGGAATC

4751 ATGAAATCAC CCTGTTACAC ACAGCATATA GTTTCTTTTT ATTTCTTGTA

4801 CACCTATTTT AACATCATAC CATATTTTTG CAGAGAGCTA TTTCTTTATT

4851 TTTATTCTTG GTTCTATATA ATTAGACTAA AATAATATTA GAAATTGTGG

4901 AAATTTAACT AGACATGGTA TCATGTGCCT GTAGTCCCAC CTATTCAAGA

4951 GATCAAGCCA GGAGAATTTC TTGATCCCAG GAGTTTAAGA CCAAGCTTGG

5001 CAATATAGCA AGAGCTTATC TCTAATTTTA AAAAGTTGTG GAATATTAGA

5051 AATTTAAATT CTGTTCTCAC ACCTGTATTA GAGAGGGTTT ACCCTGTGTT

5101 TTCCAAGTCT TTTTTATTAA GAGTATACTG TAAACTCTTT ATCTAATCGA

5151 AGAATATGCA TTTTGTTTAA AATAACAACC TGTTTGATAA GCAGAGACTC

5201 TTCATATTTC TGTGGTCAGA CTTTAACTTC ACAAGATTTT TGCATTGTAA

5251 TTAAAAAAAA ATCCGGTCGG GGTCTTTGTA TCTCATTCTA AATTTCAAAT

5301 TTCAGAGGCT TTTGTGCTTA GTTATTGAAA AAATAATTGT AAAGCTCCTG

5351 CATTCGTATG AGCCACTTGA AGCTAGAAAA ACTATTTGTA TGTATCTTGA

5401 GTACCCAGAA TAAGGTCTTG CATGTAAGAA ACATTTTATT AGTTTTTAAT

5451 GTGAATCAGC AAACAGGGAA ATGGGCTTTT TTTAATGGAA TGTTACAGGT

5501 AACATAATAT GCATAAGATA TCTAATAATT AAATCTATTA AATGTCTTGA

5551 ATGTTCTGAA TTTATCTTTT CTTCTAATGT TGAGAATCTA TAAGTTGAGG

5601 TGAGTTATGC TGAGAAAATA TGTCTGAATT TATCTTTTCT TCTAATGTTG

5651 AGAATCTATA AGTTGAGGTG AGTTATGCTG AGAAAATATG TCATAGAATA

5701 AAATGAAAAT TGGAAGAGAT GGAAAGGAAA TAGGAAAGGT GGATACAGCG

5751 TGTTTTCTAA TATCTTCCAA CTGGAAGCTT AGATTGGGAA TTTAGATTAA

5801 ATTTTCAAAG CCCCAACCAT GTTCTATTAA ATACATATTT TTCAGGACAT

5851 ACATTACTCT TTTGAATTCT GAATAAAAAT TCTTTCTCCA GGTGTTAAGT

5901 TCCTGGAATT CTATTGTTTT TTTTTTTCCT CTCTCTGTCA CTCTCTCTCT

5951 CTCTCTCTCT CTTTGTAGTA AGAATGTTTC AGCTTTCAGG TGAATGATCA

6001 TGGTTAACTC TTGGGATGTG TTATTTTATA GTAAACAATC TAAACTTTTT

6051 ATTACATAAG TATTTACACA AAACAAATTG TCGAGTAAAT GCTAACCAGC

6101 ATTATTAGGC ATATATTATG AACACAAGCT TTTCTTTTAA GCTCATATTT

6151 GATTGACTGG TCATGTCTCT TTTTTTGTTT GTTTCTCCCT CCTTCCCCTT

6201 TGTTTAAAAA TGATTTACCT CAGTCTAACT TTTTCCTTGC AGACCACATG

6251 TCTTTAGTGT CTATTCTTTC ATTTCACCTC TGTTTCTGTT GTCAGGATAC

6301 TTAGTTACAC CTTTCTATTC AGTAGCTATG TGTGGCTTTC ATTCGTGAAT

6351 CATTGCTCCA TAAAGTGGAT GGTTGCTTTG TTCTGTCTTT TTTGGAAGGA

6401 GCTGAAGTTA TACAATAATT TGTTTTTAGC TTTTGACACA CAGAATAGAA

6451 GCAACTTATA CTGATTCTGA TGCTAGCCCA TTTAAATATA TTACTACTAA

6501 AAACTACATT CTCACATTTT TTTCCCACAG GAAGTAATTC ACACAAATAT

6551 ATATCATGCA TAAATATTTT GAAAACTAAA GTGATTAATT GACTTTTGAT

6601 TAGTTTTGTT CAGTAATACT CTAAATTACG TATGAGTAAA TTTTTGTCCC

6651 AGTTTGTTGT GGTTAATAAA AGAAACTAAT GGATATCATA GTATTTGTAT

6701 AATAATCAAC CGGGGTTGAA AGGAGTAACA TTTTGAGAAT ATCTGTATCA

6751 CCAATCATAA TCATCATCTC ATGTGAATCT GTAGATAAGT AAATGGCAGA

6801 CTTGAGGTTT GAATCTACAT ATGAGTGACT TCAAAGTCTA TCCTTTTTGT

6851 GTTAGATCAT GTAGTAATGG TGGCAATTAT CATTATTTTA ACTTGCTGAA

6901 TGTTGTTCTT AAACCTATTG TGTCTTTCTT CTAGACTATT TCAGAACCAT

6951 ACTTTACGAA CAGAAGGACT ATTTCTCAAC AATCTGCAGA AAAGTGTAAG

7001 CTATTTGAAA CCTGACTATT GTATTATCTA CTGATTCTTT TTTTTTTTTC

7051 TTTCTTATTT TTTTGTAGAC AGAGTGTTAC TCACTGTTGC CCTGGCTGGA

7101 GTGCAGTGGC ATGATCTTGG CTCACTGCAA CTTCCACCTC CTGGGTTCAA

7151 GTGATTCTCC TGCCTCAGCC TCCTGAGTAG CTGGGATTAC AGGTGTGCAC

7201 CACCACACCT GGCTATTTTT GTATTTTTGG TAGAGATGGA ATTTCACCAT

7251 GTTGGCCAGG CTGGTCTTGA ACACCTGACC TCTTGTATGA TCTGCCTGCA

7301 TGGGCCCACA AAAGTGCTGG GATTAAAGTT GTGAGCCCCC ACACCCGGTT

7351 CTTATTTATT GATTCTTAAT TACACGCATT TCATCTACTC TTGACTTTTT

7401 TTTTACTGTA GTAGATGCTG CATGTGGCAT TGAAAAAACA AAATATGGAA

7451 CCTTTTTTTG AAGACCAAAA TGTTGATAAG GTAAATGAAG ATGTGGTTAA

7501 AAGCCAACAT AGAATAATCA GAGTCGAGTC CTGTTCACCA ACTCACTCTT

7551 ATCTGTTAAT GATCTCTAGT TTTACAATGG TAAATTGTTT TATTTGGAAA

7601 ATATTTTTCC CATGCTTTAT TCACTTGCCA TCTCCCTGTC TTTATAACGA

7651 TGACAAGGAT CCTATAAGGG AATGGAAGTT CTCCAGGTAA TAATAGAAAA

7701 GAAGTGTAAC AACAAGGGAA ATATATGCAT GGGACCAGGA TTCCTAAAAG

7751 GTCATGGGAG TAAATGATTG TTAGGTTTGC CATTAGGGAA GGAAAGAAGT

7801 AGAAAGCAAC CTGAAAGAAC AGCTCCACAA ATACAAAGGT GAAGAGGGGA

7851 AAGAAGTAAG AATACAGAGT TGAATAAGAG TGTCAAGATG ACAAAGATTA

7901 GTATAAAACA CCTCAAAAAC GGTGAATTTA AATGACAGTA GAATGTCTCC

7951 ATATCATATT ATAGAATTAT TTTAAATATA GATTAGGAAA AGAAAGCCAA

8001 GTAATTAAAA TAATGCTCAG ATTCTTCTGA GTGACTTACG GGTGATTTTA

8051 ATAAAGGATT GGAAGAAAAT TTATGGGTGA CTATATTTAA CATTCTGTTT

8101 AACATTTAAA AATAGCCAGG AGAGAATAAC TTGAATATTT CTAGTTTAAA

8151 TAAAACATAC ATATTTAAGG TAATGTGTAT CTCTGTTACC CTCATTAGAT

8201 TATATAGATG GAACAAATCA TCACACGTAC ACTGAAAATA TATGCATCTA

8251 TTTATTAATT TAAAAATTCT AAATGGAAAG AAAATTTAAT CCTAACTTTT

8301 TAAAATTTCA GTAAAGTGAT GTCTCATATT TTATCTAGTG AATATTGTGT

8351 TCATAGATCA TGCAAAGTAA AATGTGTTTT AGGCTATATC AGATTTTGAA

8401 TGAATCATTA ATTTTTGACT CCTGTTAAAA GTTTTTTAAA GTAATATTTG

8451 GTATATTCCC AAGTTGCTTA ACTAATTTAT TTCACTTTTA CATCATCTTG

8501 GCAGCTGTTT TAGCCTTTTT TTGATAATAG AGAAAATAAA TAAGTAATTA

8551 AATAATAGAA AATAAAAAAT AATAAAAATT AATAAAAAAA TTAATAAAAA

8601 TTAAAATTTC TGGTTAATTT TTTTTTTTTG AGAGGGAGTA TCGCTCTGTC

8651 GCCCAGGCTG GAGGGTGGTG GGTGATCTCG GCTCACTGTA AGGTCCACCT

8701 CCCGGGTTCA TGCCATTCTC CTGCCTCAAC CTCATGAGTA GCTGGGACTA

8751 TAGGTGTCCG CCATCACGCC CGGCTAATTT TTAAATATTT TTAGCGGAGA

8801 CGGGGTTTCA CTGTGTTAGC CAGGATGGTC TCGATCTCCT AACCTCATGA

8851 TCTGCCTGCC TCGGCCTCCC AAAGTGCTGG GATTACAGGC GTGAGCCACC

8901 ACACCTAGCC ATTTCTGGTT AATATTAAAG GAGGTTTCTA ATTTATGTTC

8951 ATTGAATGAG AAAAAATATC TTTTTAACCT GGAACCCTCT TAAAGAAATA

9001 AATTATTACT TATTTCTGGA GCTAGTCTGA CTGACCTTGT GCTGATAACC

9051 TCTGTACTTA AGAACATACA TGTGATGAAT GCAGTCAACA CTCATGATTG

9101 TTTTCTAAAC AAAGTACCTA TTTTGATAGA ATCGTAAGGA AAGAAATATT

9151 GCCAACAGTA CACAGAATTA TCTCTGGAAT ATTACTTTTT ACTTTTAAAA

9201 CTATCTCCTG CAGTTGGGAC GTTTTTTATT ATTCTCTGGA AGCATTATTA

9251 ACTTTAGTAT TTATAGTTAT ACCTTGCACA TAAATTTATT CAGCTCTAAA

9301 ACTCAGGAAT CCTTTTGACT TGATGTTTAA AATAAATTTC TTCTCTCTTC

9351 ATGTGAGTAT TGAGTCATGA GTGACAGGCA TAGTGTATTT GAAGACAAGT

9401 AAGTCTTCAG CTTGCATAGT CATATGATTA TTTTACTTGA TCCTTTCTCT

9451 GATTTTTAAC TATTATCTTT ATGGCATAAG TAGGCAATTA GAGCTATTAG

9501 TATATCATTT CAGGAGAATC AGAAAACCAT ATGAACTTTA AAATAGATTT

9551 TGCATTTCTC TCTTATATGT TAGAAGTACT TAAAATGCCT TATAATTCTA

9601 TAATAGAATA AACATTTGTG CAAGTTAAAA ACTTTTAAGA TGATTTTTTG

9651 AAAATGAGCT TTCTTAGGAC ACCTTGACTT ACTGGTTTAG ATAACTGTTT

9701 TCATTAAGTT CAAAAATGCA GATGACCATA ATATTCCAGA AATAAATATC

9751 TGCATACATT TAGAAAATAT ATTTTATATC TTTTAATCCA GTATAGAAAT

9801 ATATAATTGA AATTTTGAAT CACATGTTTT GTTTTCTTTT TATTTTCAAA

9851 ACTTCAGGGT TCTACATAGG TTTAAATTAT TGAATCCTAC CAGTTTAGTA

9901 TACTTTACAA ATGTTGACCT TCTCAACAAC ATATGGTTTT TTTGAGTAAG

9951 GTCATCTATT TCTACTCCAA ATGTATTTAC CCAGATCAGT CTTCTAAGTC

10001 CCCTTTGTGC CTCAAATTTA ATAGGTCTCA AACTGCCTTC CAGATTCTTT

10051 CCTGACTCTT TGTAATCCAT GCTGTCATCT CACTTCCCAA TTTTAGTAAA

10101 TAACACCAAG GAGGTAGTAA TGAAACATTG AAGCAGAAAA ACTGCACTCC

10151 AGGTTTCCCT CACATAGCCA ATCCAGTGAC TCACCAATTT TTGTATTTTC

10201 TACCTTTAAC CACTTCTCAT ATCTTATTAC TGTAATACAC TGTCGGCCCT

10251 ATACTTTTGG AATGTTCGTT TTTGTTTCTT TCTTCTCCCC ATGTTTATCT

10301 ATCTATATAT GTCTTTCAGG GTGACCTTTC TTAAACATGT TTACTTTGAT

10351 CTAAGTCATC TGTTTATGGC TGGACCCTCA TTACATGAAA CAAACATTTA

10401 CATTCTAGCA TAACACTTAT TTTGTGGTTT GGCCTGTTTC TCCCATTTTA

10451 TCTCTCCACT CCACTTTCTC TGTCTGTGTC CAAGTTTTAC CACGTTATTG

10501 TGGTATTTCT TATTGGCTAT GCTGTTTCAT GCTTTATTTT TTTGCACATG

10551 CTGCCCTCAC TAGAAACACT TCACACTCTT ACTCTTCCCT TGTCTATTTT

10601 AAAAATAGAA CCCTAAATTT GCAGTTTCTC AGAAGCTTCC CAAGTAGAAT

10651 TGTTATTGCC TTTGTGCTAT CACTGTATTT TATTGACTTG AATTGTAGAA

10701 ATAATGAATT GTGTCTTTCT GCTTTTGTTT GTTTTTATAA ATTTCTTTTT

10751 TCACTTGATA AATAAATAAA ATTGGTATTT TATTCATATT ATCAGATTTT

10801 CCAGTATAGA TCTTATGAAT TTATAGACAC GGAAAATGTT TCTTGAATTA

10851 CTGACTGATT AAGTAGTAAA TATGACATTT TCTGAAGATT TCTTTTTTTT

10901 TTTTTTAATA GGAAAGAAAA GCACTACCAG CAACTGGACA AAAAGCAAAT

10951 GGTATTGGTA TTATAAAAAG TGCTCCATGA GAGCAATCAA ATAATGATAA

11001 TGTTGTATTT TGTGTACAAT AAAAGATGGT GAGGTAGTGA ATATAGCTGA

11051 ATAATTTTCT ATGCTTTAAT AATATAATTT TTGAAAATAA ATATAACTAA

11101 TTTAAATATA ATTTAAAATA AATTTAAAAT TAAATTAATT GTTAAATTAC

11151 ATTAAATTAT AAGCCTAATT TTAATTAAAT TATAGTTATA ATTTATTAAT

11201 TTTAATAGTA AATATAATTT AATTTAAACA TACTTTTTCT TAAAACTTTG

11251 GTGAACACTT AAACTTGTAG ATCAAAATAT AATATTCATT GTTGAGAAAT

11301 GGACATTAGT ATATTTACAA AAAAATGTGA GGTGGGATTG TGTAAATTAA

11351 GAAAGCAGCT GGCTAGGTAT TTGGAGGTTT CTGATGAGGA AACTTGAGGG

11401 AACTCACTTT ATGTAGACTC AGTATATTCC CACTCAAAGA GAAGATTAAA

11451 TGATTGCTGC TTTGGAGCTT ACTGGAGGCA GAGGGTAGAA GAACGACAGG

11501 AAACCACAGA AACTCATTTC TTCTCTCTAT AGGGGTTACA CATCAATGAT

11551 ATGTGCTTCA TTCATGTTTG TTAGTGAACT GGGATGCACT TGGATATCAA

11601 AACATTGGCA GTTTTCTTTA AAACAATGCT GTTTTTGATG AAATAGCCAT

11651 TGTATAAAAG TACCTCAGAG GCTGCTATGC TATAGCATAT CAAACTGACT

11701 AGAAAAAAAA CAAACGAGAA ATTTATTTCT TTAGTACTAA AAGTGTAACT

11751 GTCAATAATC ATGGCAAATA TTTTGATATG TAAAAGTTGA TTAATCCAGG

11801 CGCAGTGACT CACGGCTGTA ATCCCAGCAC ATTGGGAGGC TGAGGCGGGA

11851 GGATCACGAG GTCAGGAGAT GGAGACCATC CTGGCTAACA TGGTGAAACC

11901 CCATCTCTAC TAAAAATACA AAAAATTAGC CAGGCGTGGT GGCATGTGCC

11951 TGTAGTCCCA GCTACTAGGG AGCCTGAGGC AGGAGAATCA CTTGAACCCG

12001 GGCGGCGGAG GTTGCTGTGA GCCGAGATTG TGCCACTGCA CTCCAGCCTA

12051 GGTAACAGAG CAAGACTCCA TGTCAAAAAA GAAAGTTGAT TAGTATGAAA

12101 AAAAAGTCAA TGGTGATTCA GAGATTTTTG GTTACATTTT GTAAATGAAA

12151 ATCTGAGTAC TCATTAGTTA TTTGATGTGT AACATATACT TTTTTTGCAT

12201 AAGGGAATGA AAAGATGGCA AGAGAACTAA AGTTGAGAAT CCAGAAGTTG

12251 AAAATATCAG AAGTCTTCAT GACTGTGGAT AACATGAGTA TTTTTAGAAA

12301 CGATTTTTCT CCAAGTAGAT ATCTAAACTA ATGATTGAGA GCATTTCCTG

12351 CCAGCAGAAG CGAATGATAC ATTTTCTTTT CTTTTCTTTT TTTTTGAGAC

12401 CGAGTCTCGC TCTGTCACCC AGGCTTGAAT GCAGTTGCGG GATCTCAGCT

12451 CACTGCCAAC TCCGCCTCCC GGGGTTCACG CCATTCTCCT GCCTCAGCCT

12501 CCTGAGTAGC TGGGACTACA GGCGCCTGCC ACCAAGCCCA GCTACTTTTA

12551 TGCATTTTTA GTAGAGATGG GGTTTCACGG TGTTAGCCAG GATGGTATCG

12601 ATCTGCTGAC TTCGTGATCT GCCCGCCTCG GCCTCCCAAA GTGCTGGGAT

12651 TACAGGCGTG AGCCACCGCG CCCGGCCGCG AATAATACAT TTTCATGCTC

12701 TCTCATTGCA ACTTCATAGT TTCTAACATT TATTCTTCTG GGGTCCGCTT

12751 TGGTTCTCTC ATTTGACGTC ACTTTTTTTG GCTTCATCCA GCAGATTCGC

12801 ATTCGTAGAA ATACTTTTCT ATGTTACTTG TAGTCATGTG AAACCTAATC

12851 TCACCCTTGC AATCTGGACT GCATGTTTTA TAGAATCTAT ATTGTGATTT

12901 TTCATGTGTA TATTCCTGTC ATGTTTGTGT GTTAACCAAA ACAAGAGCAA

12951 AGCAACCCAA AGCCTAATGG GTAACAATTT CAAGGGCAAG GACGAAGATT

13001 TCAGCTGGAT ACAAACACTG CATGATTGAT GGTAGGCTAT GTCATATTTC

13051 CCTGTAGTCA ATTTTGTGTT CCTTTTGTTT TTTAGTGTCT CCTGAGCAAC

13101 CGCCTTTATT CACGGTAAGC ATATTTTCTT TAATTATTAA CAAAATGCTC

13151 TGTGATATAT ACATGATATA TTAATCATTA TGTTGTCAAA CCCATTCAGC

13201 ATACGGTGAA AGACAGAGAT CACATTTCAA CTAGATTCTT AGGAAGTATG

13251 GATTCACCAA CTTCCAGTGA AGGTAAATTT GCCACTACAA ATTTCATTCT

13301 AGAAAATGTA GATGAAAATA TTGAAAATGC TCATAGTTTT TTGATTCCCA

13351 CTTTTTATCC AAATGAGATG GAAGGATTTG ATGTAAATAT GCTGATGTTC

13401 TTGTTAATAT CTTTGTTTAT AAAATGATAT TTAAGGCATA AGGCGGACAT

13451 TTTACACCAT GAGCTCTAGC CCAAATGCTT TTCCTTTAAA GTTGTCATCA

13501 TCTGAAGATC CCAGTTTTGA ATTCCTGTGC ATGTTAGGGA TTTGAGGAGG

13551 TGTATTTTGA CACTAAGTAT TTTCAGTGCT TCAAAATTGA TTGGAATACT

13601 CTTCTCTCTT CTTCATCTAG AGAAAAGCTA TACCTGCTGA CGTTACAATT

13651 GTTTTAGAAC TTCAACTCCT TTATGTCAGT GTTGTTACAT TGAGAATCTT

13701 TACTTAATCA CATCTTCTGA TTACCAGATT GAGTTTCTGC ATGTGTATGT

13751 GTGTGTGCAT CTCAGATTAA GAATGAATAA AATGATTAAT CATTCTTTTG

13801 TAACTCTTTG GTAGATACAG TGTTTTAAAA CAATGATTCT GAGCTGTTTT

13851 GGCCTTAGAA TATTTTCTTC TACTACAATT TATTGCCTAC AGGTAGCCAA

13901 CAGCCTGAAT TAACGTTTTT TACTTTTAAG TCACTGCAAT GCACATTAAA

13951 AATACTTTAC AAGATACTTG CACTTTCATA GGTAATATGT AGAATCTGTT

14001 TCCAAGTATC AAGTCTTCTA TACGATTTCA CACAGCGTAC ATAATAGCTG

14051 CAACTCGGCT TTTCTAATCA GTGGTATATA TTTTGGATCT ATCCAGGTTG

14101 ACACAATTTG TTCATCTTTG ATTTGTTGTA TGGTCTTGTG GTATGCCATT

14151 TTATGACTGC ACCACAATTA ATTAAAGTCT CTTCATGCTG ATACAAAATG

14201 AACATAAATA TGATGACATG CCAACATAGA TTTGCTTATG TGGTTGTCTT

14251 TATTGATTTG TACTATATAA GAAATTAAAT AGAAGTATTT CAGATACCCT

14301 GAGTATAGCT GTATACACTG CCATAGCTGT ATTGACTACA TTCATTACCC

14351 CTTAGAGCCA TGTTTTTCCA TCATATTATG ACTCTGAAAA GCCCTAGTGT

14401 ATGCTTTTCA GAGAATGACA TTGGAAAGAA GAAACGGCCA AAGTATCATT

14451 TGGTACCTTG GCTTCCTTAC ATAGATGTTG AACTCCAAGA ATGATCAAAT

14501 CACAGTTTAG AACCCCTTTG TTGGCCCTAT AAAGGGTTTC TGGATATCAA

14551 ATGATAAATA GTCTCCAGAT GAAGAAATGC TCTATAACGC CCCACCGCTG

14601 TGTTTTCCTA TATTTTGTCC TTTTCTGAAA ACTTTAAATA CACGAATTTT

14651 TGGTAGAAAT GAAAATCTTT CTGTTTTATA TATTTGTTTC TGTCCATGGC

14701 ACTCTGATAT CTTTGAATCT AGTAAGGATA TAGCCTTGTC TTATTTATAC

14751 CAGCAAGCAG TGTTGTCACT TAATGCTCTC ATTTTTCACG TAAATGACTG

14801 ACATTTTCCC AAGTCTTCGC AAGTGATTTT TGAAGACGTT GCTGCATTAA

14851 GCAGAGACTA TGTCATTGTA ATTGCAGAAG TTTTTAAATT AAATATGTTT

14901 AATAAAATTT TAGAGCCTGT TTCTGTGGAA CACGTAACAC ATAATGGTGG

14951 TGTAATGTGT ATTTAACCAT AAATTAGCTT CACAAAAATT TGTGTACTTA

15001 AAAGTGTTTA TATCCAAAGA AATTCTTATT TACTGCTCAG TAATCTCTTG

15051 TGTAGAAGAA AATATGTAAC ATAGTTTGCT GAGTCTTTGA TAATAACCCC

15101 CAGTGTAAAA TAAAGCTGTA AAGATGAAAT GAGAGTTGAT ACTCAATGAA

15151 ACTGATGTGA GTGAATACAA ACTATGAAAC TGTGTCTAGG GGAGAGAGGA

15201 GGACATGGGG CTGCTATTGT GAAGAAGGAA TTTGTACAAG TTAGTCCATT

15251 TTCTGTAACT TTTATATTCT AATAAAGGAA AACCATATCT TCATATTTAT

15301 AAAAATGGGA TTTTACTGGT TTGATCACAG GGGTTGTGAG AATAATGAAG

15351 AACAAAATGT GGAAGGCAAA GAATGAAGAC CAGATAGTGA GATTAGATTT

15401 ATCAACAAAA AAGAGTGCAA GTGGGGTGGG ATGGTGTAAA TAAAGACAGC

15451 AGCTGGCTAG GTATTTGGGG GTTTCTGATG AGGAAACCTG AGAAAACTCA

15501 CTTTATGTGG ACCTGGTATA TTCGCAGTCG AACAGAATAT TCGATTATTG

15551 TTGCTTCAGA GCTTAATGGA AGCAGAGGTG GAAGAATGAG TAAACCACAG

15601 GGACTCAATT CTTCTCTCTG TAGGGGTAAC ACATCGACAC TAGGATAGGT

15651 GCTTCATGTT AGCAAAATGC GATGCAGTGC ATGTCAAACT GTGGAAGCAA

15701 AACAATCAAG AAATAAATTT CTTAAGTATT ATTTATTTAT TTATCGTTAT

15751 TATACTTTAA GTTTTAGGGT ACATGTGCAC AACGTGCAGG TTTGTTAAAA

15801 TGTAACTGTC AATGATCATG GCAAATATTT TGATATATAA AAGGTGATTA

15851 ACATGAAAAA AGCCTCTGAT ATTTCAAATA TTTTGGTTAG ATTTGTTTTA

15901 TGGGAATCTA ATTACATATT AGGTATTTGG AGTGTAATGT ATACATTTCT

15951 TGCATAAGTG AATGAAGAGA TGGCAGGAGG GCTAAAGTTG AGAATCCAGG

16001 AAATGGAAAA ACACCAGAAG TCTGCATGAC TGTGGACAAC ATGAGTATTT

16051 TTGTTAACTA TGCTTCTGTA TGTAGATATC TGAACTAATG AACTGAGAAT

16101 ACATCCTGCA AGCAGAAGGG AATGATACAT TTTAATGAAA CTGATAGTTT

16151 TTAAGTTAGA GGACAAAATG AAGAACACGA AAACTATTGT AGTATTGTAG

16201 TATAAATGGT TCTTGGGTGA TTTCTTCAGG GTACACCATA GCGTTCTACC

16251 ATGGGCTTTG ACATTTATCC TCCTGGGGTC CTTTCATTTG ACATCACATT

16301 TTTTGGCTTC AGTTAAGAGA ATCACATTGG TAGAAGTACT TCCTTGTGTT

16351 AGTTGTAGTC ATGTGAAACC TAATCTCTCT CTTGAAATCT GGACTACATG

16401 TTTTATGAAA ACTTAATTAT GTGTCCCTTT TGCTTTGTAG AATCTTCTGA

16451 GCGACCTCCT TTATCCACAG TAAACAAATA TATTTTCGTT TTTAATTAAC

16501 AAAATGCTTT GTGATATATA TATGATATAT TAATCAATTA ATCATTATGT

16551 TGTAAAACCC ATTCAGCTTA CTCTGAAAGA GGCAGATCCC AGTTCAAAAG

16601 TAGCCATGAG AAGGAAGGAT TCACCACCTC CAGGAAAAGG TAAATTTGCC

16651 AATACAAATT TCATCTGGAA AGAAGGACAT GAATATATTG GAAATGTTCA

16701 TGGTCTTCTG ATTCTTATTT CTTTTACCCC AATAAGATAG AAGGATTTGA

16751 TCTAAATGAT GCTGATGCTG TTGTTAGTGT CTATGATTAT AAAATGATAT

16801 TTAGAAGAAC AAGGAAAAGA AATGTTTAAA ATGTGAGCTC TAGCTCAGAT

16851 GCTTTTCCTT TTAGGTTGTG ATAAATATCC AATGTGGAAT TTGTATGCAT

16901 GTTAGGGGTT CAAGGAGGTG AATTTTGAAA CTATAAATAT TTTTCAGTGT

16951 TTCAATTTCT GGTTGCAATA CTGTCCTTTA CCTAGAGAAA AGCTATACCA

17001 GCTGACATTA CAATTGTGTT AGAACTTCAA CTTCTTTATG TCGGTGTTGC

17051 CACACTGAGA ACCTTCAAAT CCTCACCCAG TCACATGCTC TGATTACCAG

17101 CTTTTGAATT TCTGCATGTG TATGTGCGTG TGTGCTTTTG TTTGTGAGTT

17151 TGGGTGTGTG TGATACCTCT GATTCTGGAA AATGAATAAA GTCATTAATC

17201 ATTTTTTGGT GACTCTTTGG TAGATACAGG GTTTTAAAGC AATGATTCTG

17251 AGCTGTTTTA GCCTTAGAAT CTTTTCTACT ACTACAATTC ATTGCCTACA

17301 GGTAACCAAC AACCTGAATT AATGTTGGTT CGTTTGTTTT GTATTATACC

17351 ATAAGTTCAG GGATACATGT GAAGAACATG CAGGTTTTTT ACATAGGCAT

17401 ACATGTGCCA TGGTGGTTTA CTGTACCCAT CAACCCATCA GCTACATTAG

17451 GTATTTCTAC TAATACTATC CCTCCCCTAG GACCCCAACC CCCTGACAGG

17501 CCCCGGTGTG TGATGTTCGC CTCCCTGTGT CCATGTGTTC TCATTGTTCA

17551 ACTCCCACTT ACGAGTGAGA AAATGTGGTG TTTGGTTTTC TTTTCCTGTG

17601 TTAGTTTGCT GAGAATGATG GTTTCAGGCT TCATCCATGT CTTTGCAAAG

17651 GACGTGAACT CATCCTTTTT TATGGCTGCA TAGTATTCCA TGATGTGTAT

17701 ATGCCACATT TTCTTTATCC AGCCTATCAC TGATGGGCAT GCGGGTTGGG

17751 TCCAAGTCTT TGCTATTGTG AATAGTGCTG CAATAGACAT ACATGTGCAT

17801 GTGTCTTTAG AGTAGAATTA TTTTTAATCT TTGGGGTATG TATTCAGTAA

17851 TGGGATTGCT GGGTCAAATA GTATTTCTTG TTCTAGATCC TTGAAGAATC

17901 ACCACACTGT CTTCCACAGT GGTTGAAATA ATTGACACTC CCACCAACAA

17951 TATAAAAGTG TTCCTATTTC TCCACATCCT CTCCAGCATC TGTTGTTTCC

18001 TGACTTTTTA ATGATCACCG TTCTAACTGG CGTGAGATGG TATCTCATTG

18051 TGGTTTTGAT TTGCATTTCT CTAATGTTCA GTGATGATGA GCCTTTTTTT

18101 CATATGTTTA CTGGCTGAAT AGATGTCTTC CTTTGAGCAT ATCCTTCACC

18151 CACTTTTTGA TGAGGTTGTC TGTTCTTTTC TCATAAATTT GTTTAAGTTC

18201 CTTTTAGATT CTGGATATTA GCCTTTTGTC AGATGGAGAG ATTGCAAACA

18251 TTTTCTCCTG TTCTGTGGGT TGCCTGTTCA CTCTGATAAT GGTATTGGAA

18301 GTTCTGGCCA GGGCAATCAG ACAAGAGGAA AAAATAAAGG GTATTCAAAT

18351 AGGAAAAAAG GAAGTCAAAT TGTCTCTGCA GATGATATGA TTGTATATTT

18401 AGGAAACCAA AACGTCTCAG CCCCAAATCT CCTTCAGCTG ATAAGCAACA

18451 TCAGCAAAGT CTCAGGATAC AAAATCAGTG TGCAAAAATC GCAATCATTC

18501 CTATACAACG ATAAAAGACA AACAGCCAAA TCATGAGTGA ATGTCCATTC

18551 ACAGTTGCTA CAAAGAGAAT AAAATACCTA GGAATACAAC TCACAAGGGA

18601 TGGGAAAGAC CTCTTCAAGA ACTACAAACC ACTGCTCAAG GATATAAGAG

18651 AGGACACAAA CAAATGGAAA AACATTCCAT GCTCATGGAT AGGAAGAAGC

18701 AATATCATGA AAATGTCTAT ACTGCCCAAA GTAATTTATA GGTTCAGTGC

18751 TATAGACTAC CATTGACTTT CTTCACAGAA TTAGAAAAAA ACTACTGGAA

18801 ATTTCATATG GAACCAAAAA AGAGCTCATA TAGCCGAGAC AATTGTAACC

18851 AAAAAGAACA GAGCTGGAGG CATCACGCTG TCTGACTTCA AACTATACTA

18901 CAAGGCTATA GTAATGAAAA CAACATGGTA CAGGTACCAA AACAGGGATA

18951 TAGACCAATG GAACAGAACA GAGGCCTCAG AAGTAACACC ATACATCTAC

19001 AACCATATGA TCTTTGACAG ACCTGACAAA AAATAATCAA TGGGGAAAAG

19051 ATTACCTATT TAATAAATGG TGTTGGGAAA ACTGGCTAGC CTTATGCAGG

19101 AAACTGAAAC TGGACCACTT CCTTACACCT TATACAAAAA TTAACTCAAG

19151 ATAAATTAAA GACTTAAATG TTTAAGTAAG ACCTAAAACC ATAATAACCC

19201 TAGAAGACAA CCTAGGCAAT ACCATTCAGG ACATTGGCAT GGGCAAAGAC

19251 TTCATGACTA AAACACCAAA AGCAGTGGCA ACAAAAGCCA AAATTGACAA

19301 ACGGGATCTA ATTCAACTAA GGAACTTGTG CAGCTTTATT TGGAAGTGTG

19351 CAATGAGGTA CGTCTGAGTT TCAAAAATGA AGAAAGTAAG TAGTCATGCT

19401 TTCCTGACTC TTTGGTAGAC AGCCTTTTAA GACGGTGATT CTGAGCTGTT

19451 ACTGTTTTGG GTTTTCTATA ATACTAAAGC TTACTGCCAA AATGTAACCA

19501 AGAGCTTGAA TTAAGTAAAA AGAAATCACC CAAATGCACA TTAAAAACCT

19551 CTTACAACAT ATGTGCACAT TCATAGATAA CATGTAGAAC TTGATTTTGT

19601 GTATTAAAAA CTTGTAGAAA AGTTCAGGCA GTGCACTTAT TGAATGCAAC

19651 TTGGTCTTTG TAAAATCAGT GATATATATT TCAGATCTAT CCACCTTGAC

19701 CCAGTGAGGT ATTTCTTGAT TTATTGTATG ATCTCATGAT ATGCCATGTG

19751 ATGACTACAG CATATTATGC TCTCTTCATG CTGATACCAT ATGGACTTAA

19801 ATATGATGAC ATACCAGCAT GGATATGCTT ACGTGGTTGG TTTTATTGAT

19851 TTGTACTATA TTAGAAATGA AACAGAAGTA TTGGAAATCC TAGCAAGCAT

19901 AGCTGTATCT CTCCCATGGC TGTGTTAATT GCAACTGTTT CCCCCTTAAA

19951 GCATGTCTGT TTGACATGTC CTAACTCTGA GAAAATCCAG TGTGTGCTTT

20001 TCAGAGAATA GCAGTAAGGA GTGGAAATGG CCAATGGTCA AAGTGTTACT

20051 TGTCCTCTTG GCTCCCCTTC ATGAATGTTA AACTCTAAAC TACTCAGGTC

20101 ACAATTTAGA ACCCCTTTGT TGATCCCTAT AGAGTGTTCC CAGATATCAA

20151 ATGACAAATA GGTCTTTGAT GAAGAAACAC CCTGTAAAGC CATATTGCTC

20201 TGGTTTTTGT GTGTGAGTGT GTGTGTGTGT ATGTGTGTGT ATTTTCTTCT

20251 CTTTTGAAAA CTGTAAATAG AGGAATTTTC ATTACAAATG AAAATGTTTC

20301 TGTTCCATAT TTATTTCCTG TCTAATGTAC TTTGCTCTTC CTGGATCTAG

20351 TAAGGATCTC AGCTTGTCTT TTTTATACCT GCAAAAAATT ACATCAAGCT

20401 TCATTTTTCA TGTCAATTAC TGACATATTT TCAAGCCTTC ACAAGTTATT

20451 TCTGAAGATT TGGTGCATCA AGGAGAGACT GTCATTGTAG TTAAAGAAGT

20501 TTTTAAATAG GTTATATTCA ATAAAATTTC AGAGCTTGTT TCTCTGGAAA

20551 GCATAGACAT AGTGGTGTTA TGGGTAGTTA AACATAAAAT AGCTCCACAA

20601 AGTGTTGTGT ACATAAAAGT GTTCATATCC TGGAAAATTC TACTTTATTG

20651 CTCAATACTG TCTGCTGGAG AGGAAAATAG GTAAGATAGG CTGCTGAGCC

20701 TATGATAATA ACTCATAATA TGAGGTGAAA GCATAGAGAC AAAATGAGAG

20751 ATGATAGATA CTCAAATGGA TGTGAGTGAA GAACAGCTGT GAACGTGTCT

20801 ATGGGAGATA GGAGGCCATG GGGCTGCTTT TGTGAAGAAG GAATTTGTAC

20851 ACGTTAGTCA AGTGTCTTGA CACATTTAAC ATTTTAATAA AGCTAAACCT

20901 TATCTTCAGA TGTGTCAGAA TGGGATTGTA CAGATGTCAC ATTACAGTGG

20951 TGGTGAAAAT AATGAAGAAA CGAATGTAAG GGTCAAAGAA TCAAGTCCAC

21001 CAATATGGAT ATTAGATTTA TGAATGAAAA AGAGTGTATG TCAAATTGGG

21051 CAGGTGTAAA CAAAGAAAGC AGCTAGCTAG GTAATTTGGA GGTTTCTGAT

21101 GAGGAGATTT GTGGGAAGTC ACTTAATGGA AAGCAGAGGT TAGAAGGATG

21151 AGGGTGACCC ACAGGATCTC ATTTCTTCTC CCTAGAAGTT TTGCACATCA

21201 ATGATACATG CTTCATTCAC ATCAGTTTTT CTTTTTTGGA AAGCTGTGTT

21251 TGCTGGTGTA GTTATTTTGT AAAAGAACCT GAGAGACCCC TATGGTATAT

21301 CATGTGAAAC TAGATTTAGA AAAAAGGAAT CAAATAATGC ATTTTTAGAG

21351 TACTAAACAG ATAACTGCCA ATAATGGTGA CAATCATGAC ATATGTATAT

21401 ATATGTATTA TGTCGTATTG GTTGGTTATT TATAAGAAAA GAAGTCTCTA

21451 GTGATTTAGA AACTTTAGTT TATTTTCATA GGAATCTGAT TACACATTAT

21501 TTCACTGATG TGTATGTTTT TGCAAAAGTG GACGAAGAGA CGGTGAGAAG

21551 GCCGAACTGC TGAATCCAGG AAATGTAAAA ACATCAGGAG TCTTCATGAG

21601 CATAAACAAA ATGATTTTTT AAATTATAAC TCTTAGATTA AGTGAACTCA

21651 CTTCAGATGC ATTCAGAATA TTTGCATAAA GGATGATTTG ATTTTTGGCT

21701 GTTCCAGGAA CTACTGGAAG CAGGAAACAG TGATAGAATT GGGATAAACC

21751 ACAGTGACTC ATTATTCCTC TTTGTTACTA TTGGGCACCA GAGGTATATG

21801 TTTTGTTGAT ATTGGTTATT CAAATGAGAT AAACGTGAAT ATGCATACAT

21851 TGGCTTTGTT TTTCAAGGAG GTATTGGATA AAATAGCAAC TTAATAAAAA

21901 TTCTCTAGAG AATAACATGA TAATTTAACC AGACTATTTT AGAAGTGAAA

21951 ATAATGTTGA ATTCATTACT TGACTCCCAA ATGGTTATTT TCAAGGAATA

22001 TTGGCGTGAT TTCCAGATGT AAAAGCTTAT TCATATCTAA TGCTTGTAGC

22051 AATTTTATTT TGTATAAGTA TGTCAAATTT GGTAATTTAT TATACTTTTT

22101 GATGAAGTTT ATACATTATA CCTTGTTGCC ATGAGTGGAT GAAGATTTCG

22151 GAAGGCTAAA CTAGAAGATG CAAGAGATGT AGGCACATTA TTACACCATA

22201 TGGGTATGAG AAATAATGAA CATTACATAC TATAATTCAC CAAACATATA

22251 TCCAAGCTGA TTAAATTAGG ACACTTCCAC TGAAGTGATG TGAAGTGTAC

22301 ATTCAACTAA AGTGTCATTA TAATTGTGTA CCTTCTCACT GATTGGTCAA

22351 GTTAAAGAAC ATGATGAATG TTTGCAGTAA AATGTTCCAA ATCATTCTGA

22401 TATCTTGCAT GAAAGACACG CGGGTGCATG TATCACCTGC TTTGACGTTG

22451 ATTCCCAGGT GTATGAGTTG AACTCTGATT TTAGATCACA TTTGTCCTCA

22501 ACACTCAGCA TATCCACATT GATATTGACA TGGCTTTATT TTAGTTCTAG

22551 ACATATGGAG AAAGTTATAT CACATTTGAA ATTGTCAGTA TATATTTCTT

22601 GAAGCCTGTA TTACTATTTT CTTCAGTGTA TTTCCTTCAT GTTTAGTCCC

22651 AAGAAACAAA GTATAAAATA TCAAAGCCTA CAGTAATACA GGCAGGAGTA

22701 TAAAACTTGA TGCTAACATG CTATCCATGC ATTAATGTAT GGATAACATT

22751 ATCATATTTA CATATGATTG ATTATGTAAC CCTTTTGCTT TTCAGTGTCT

22801 TCTCAGAAAC AACCAGCTGA GAAGGTAATT AAAGTCTCAT TTATCTGTTG

22851 AATTATTAAC TGTATAGTCT ATGAAACCTA CTTTACGTAT TATTTTGTTT

22901 TCAAATCCCA TTCAGGCTAC AAGTAATGAG AAATATTCTG TTTCAAATAC

22951 AGCCACAGAA ATAAAGGGGG GACCAATATC TGGGACAGGT AATTTTGCAA

23001 AACACATCTA ATGTCACGTT CAATCAAGAT AGAAGAGAAC GTCCCTTCTC

23051 CAAATAAATC AGTGGAGAGT TCATCTAAGC TGCACGTTCT GATTCAGTAT

23101 GCCTGAGATT GTTCATTTGT AGTGAGTTCT CAGGTGACCC TGATGCTGCT

23151 GGTCCTTGGC CATGATCTGA GTAGTAAGAT TATAGACTTC CCTACATTGA

23201 AATTGGGAAG AAGAACCATT GGAGAGCAGT TCAACACATA CCAGGCTAAG

23251 GGAGCAGCAT AATTTTGCTT TAATTCTACA GCATGTTTCC ATCAAGAGGG

23301 GAAAGAGAAC GAGATGAAGT AATAGATATT ATAGGCATCA TATCGTATTG

23351 TTATAAACAG AGGGACAAGT GATCTGAATA ACTCCACAAA CACTGTAGAA

23401 TGAGAACTAA GAAGACCACT GATGGAGCAA TTATTTTCCT CAAGGAAGAG

23451 GGATTGTGAG GCAGGAAGGA GGAAAAAGAA GAAAGTATTT ATGTAATTTT

23501 GGGGTTTCTG CTGAGGAAAC CTGAGTGAAC TCATTTCAGA TGCATTTGGA

23551 ATATTTGCAT TAAAGAAGAT TTGATTTTGG CTGCTCCAAG AAATACTGGA

23601 AGCAGGAAAC AATGCTAGAA TCGGGATAAA CCACAGTGAC TCATTACTCC

23651 TCTTTGTTAC TATTAGGCAT CAGAGATACA TGTTTTGTTG ACTTTAATTA

23701 TAAAAATGAG ATAAACTTGC ATATGAATAC ATTGGCTTCC TTGTTCAAGG

23751 AGCTACCTCT TGGATAAAAT AGCTATTTCA CAAAACTTCT TTAGAGAATA

23801 ACATGATAAT CCCAACAAGG CTATTTTAGA AACAAAAATG ATGTTGAATT

23851 CTAATTAACT CCTAAAGTGG TCATTTTCAA TGAATACTGG GGTGATTTCT

23901 GAATGTAAAA CTTATCAATA TCTAATGCTT GTAGCAGTTT TACTTTGTAG

23951 AAGTATGTTA ACATCGGTAA TTGATGATAT TTTTATTGAG GCTAATATAT

24001 TATCCTTTGG TGCCATGAGT GGATGAAGAA ACTTTCAGAA GGCTAAACTA

24051 GTGGATACAA GAAACTTAGG CAAATTATTA CACCACATGG GTGTGAGAAA

24101 TAATGAATAT TATCTACTAG GTTTCAGGAA ACATATGTCC AAGGTGATCA

24151 ACTTAGGACA CTTCCACTGA AGAGACATGA AATGTAAATT TAACTGAATT

24201 GTCATTGTAA TTGTGTATGT TCTACTTATT GGGCAAGTTA AAGGGCACGA

24251 TGAACGTTTG TAGTATAATG GTGTAAATCC TTCTAATTTC TTGCAAGAAA

24301 GACATACTGG GTCATGTACC ACCTGCTTTG ACATTGATTC TCAGGTGTGT

24351 GAGTTACTCC TCTGATTTGT CCTCATCACT CAGCATATCC ACATTGATAT

24401 TGACACGGTT TTATTTTAGT TTTAGACATA TCACGAATCA TACCATGTTT

24451 GAAATTGTAA GGGTATATTT TGTGAAGCCT GTATTCCTTT TTTTTCAGTG

24501 TATTTCTGTC TTGTTCCAGT CTCCAGACAA AAAGTAGGAA ACATCAAAGC

24551 CTACACTAGT GCAGGCAGGA AGATACAGCT TGATAATAAC ACTGCATGAT

24601 ATATGGATAA ATTTATCATA TGTACATATG AGTGATTATG TATCCCTTTT

24651 GCTTTTCAGT GTCTTCTCAG AAACAACCAG CTGAGAAGGT AAACTCTCCT

24701 TTATATTTTT TATTAGTAAC TGTATGGTCT TTGAAACATT CTTTATATAT

24751 TGATAATTTG CTCCAAATTA CTTTCAGGCT ACAAGTGACA AGACAGATTC

24801 TGTTTTGAAT ATAGCTACAG AAATAAAGGA TGCTTTAAAG TTCATATGGA

24851 ACCAAAAAAG AGCCTGCATC ACCAAGTCAA TCCTAAGCCA AAAGAACAAA

24901 GCTGCAGGCA TCACACTACC TGACTTCAAA CTATACTACA AGGCTACAGT

24951 AACCAAAACA GCATGGTACT GGTACCAAAA CAGAGATATA GATCAATGGA

25001 ACAGAACAGA GCCCTCAGAA ATAACACCGC ATATCTACAA CTATCTGATC

25051 TTTGACAAAC CTGAGAAAAA CAAGCAATGG GGAAAGGATT CCCTATTTAA

25101 TAAATGGTGC TGGGAAAACT GGCTAGCCAT ATGGAGAAAG CTGAAACTGG

25151 ATCCTTTCCT TACACCTTAT ACAAAAATCA ATTCAAGATG GATTAAAGAC

25201 TTAAACATTA GACCTAAAAG CATAAAAACC CTAGAAGAAA ACCTAGGCAA

25251 TACCATTCAG GACATAGGCA TGGGCAAGGA CTTCATGTCT AAAACACAAA

25301 AAGCAATGGC AACAAAAGAC AAAATTGACA AATGGGATCT AATTAAACTA

25351 AAGAGCTTCT GCACAGCAAG AGAAACTACC ATCAGAGTGA ACAGGCAACC

25401 TACAAAATGG GAGAAAATTT TCGCAACCTA CTCATTGACA AAGGGCTAAT

25451 ATCCAGAATC TACAATGAAC TGAAACAAAT TTACAAGAAA AAAACAAACA

25501 ACCCCATCAA AAAGTGGGCA AAGGACATGA ACAGACACTT CTCAAAAGAA

25551 GACATTTATG CAGCCAAAAA ACACATGAAA AAATGCTCAT CATCACTGGC

25601 CATCAGAGAA ATGCAAATCA AAACCACAGA GATACCATCT CACCCCAGTT

25651 AGAATGGCAA TCATTAAAAA GTCAGGAAAC AACAGGTGCT GGAGAGGATG

25701 TGGAGAAATA GGAACATTTT TACACTGTTG TTGGGACTGT AAACTAGTTC

25751 AACCATTGTG GAAGTCAGTG TGGCGATTCC TCAGGGATCT AGAACTAGAA

25801 ATACCATTTG ACCCAGCAAT CCCATTACTG GGTATATACC CAAAGGACTA

25851 TAAATCATGC TGCTATAAAG ACACATGCAC GTGTATGTTT ATTGCGGCAC

25901 TATTCACAAT AGCAAAGACT TGGAACCAAC CCAAATGTCC AACAATGATA

25951 GACTGGATTA AGAAAATGTG GCACATATAC ACCATGGAAT ACTATGCAGC

26001 CATAAAAAAT GATGAGTTCA TGTCCTTTGT AGGGACATGG ATGAAATTGG

26051 AAATCATCAT TCTCAGTAAA CTATCGCAAG AACAAAAAAC CAAACACCGC

26101 ATATTCTCAC TCATAGGTGG GAATTGAACA ATGATATCAC ATGGACACAG

26151 GAAGGGGAAC ATCACACTCT GGGGACTGTG GTGGGGTGGG AGGAGGGGGG

26201 AGGGATAGCT TTGGGAGATA TACCTATTGC TAGATGATGA GTTAGTGTGC

26251 AGCGCACCAG CATGGCACAT GTATACATAT GTAACTAACC TGCACAATGT

26301 GCACATGTAC CCTAAAACTT TAATAATAAA AGAAAGAAAA AGAAAAAAAA

26351 TTAAATATGG TACTGAAGCA AATAAACCAC TAATAGCTGA GAAAAATAAA

26401 TAAAAATAAA TTGTTGATGT AAAAAAAAAA GGATGCACTA CAATGTGGGA

26451 CAGGTAATTT TGCAAAACAC ATTTAATGTC ATTTTCAATC ATTTAGAAAA

26501 GAACTTCTCT TCCCCGAATA AATCAGCGGG GCGGGGCTCG TCGAAGCTGC

26551 ACTTTCTGAT TCAGCAGACC TGAGATTCTT CATTTGTAAT AAATTCTCGG

26601 GTGATGCTGA TGCTGCTGAT CTGGAACATG ATCTTCGCAG TAATATTATA

26651 CACTTCCCCA CATTGAAATT GGGAAGAAGA AACATTGGAG AGCAGATCAA

26701 GACATAAGGG GATCAGGGGA CAGCATAATT TTGCTTTAAT TCTACAGCAT

26751 GTTTTCACCA AGGGTGGAAG GAGAATGAGT TGAAGTATAG ATTTTACAGA

26801 CGTCACATCG TATTGCTAAA AACAGACGGA AAAGTTATTG TAATAACCAG

26851 TAAAATTGTG GAACGAGAAC CAATGAGACC ACTGATGTAG CAATTATTTT

26901 ACTCTAGCAA GAGGGATTGT GAGGCAGGAA GGAGGGAAAA GAAGAAGTTA

26951 TTTATGTAAT TTTGGGGTTT CTGCTGAGGA AACCTGAGTC AACTCACTTC

27001 AGATGCATTT AGCATGTTTA CACAAAAAGG ATTTTATTTT GGCAGCTCCA

27051 GGAACTACTG GATGAAGCAA AGAAAGCTAG AATTGGGATA AACCACATTG

27101 ACTAATTACT TCTCTTCGTT ACTATTAGGC ATAAGACATA TCTTTTGTTG

27151 ATTTTTGTTA TAAAAATTAG ATAAACTTGA ATATCAATAC ATTGGCTTCA

27201 TTCATCCAAG TGCTATCTCA TGGCTAAAAT AGCTATTTAA TGAATATGAT

27251 TTAGAGGATA GCATAATCCT CCTAATGAGA CAAAAACAAC TATAATGTTG

27301 AGTTCATCAA CTGACTCTTA AAATGGTTCA CAGGCGTGAA CCACCGTGCC

27351 TGGCCTAAAA ATATAAGGTT TTATTCAGAT GTTTCTACTT TTACATTTTG

27401 ATACTCTGAA GTTTCCAATT TGGAATTTCA ATAGTTTTTA GAGATTTAAA

27451 GAGATCAATT TTGACACTGT AAAATATTTG TTTTGCTTTA AAAGTCAATT

27501 CAAATTATGG CCACTTTGGT CTCATATATT GTGAGGCTGG TTTGTTATTA

27551 GGGGCATAAA GACTTAGGAT TGTTATGTTT TGTTGATTAA CTGAACCTTT

27601 TACTATTGTG ACATGACATT TGTTATTTAT TGATAGAATT TTTTTTTTTT

27651 TTGCTATGAA ATCTACTTTG TTATTAATAC AGCCACTCCT GCTCTGCTGC

27701 CTTTGGCAAC TGTTAGCATG TATCTTTTTC CATCCTTACA ACCAATTTGT

27751 GTCTTTACAT TTAAAGTGCA TTTCTTATAG GCAGCCTGCA GTTGGGTCTT

27801 GCTTTCTTGC TGAGCCTGAC AGTCTGTATT ATAGTTGAGG TTCTTAGACA

27851 AGTGTCGTTT ATAATGTGAC TATTGATACA GTTATGTTTG TCTAGTAGCT

27901 GTTTGATTGC TATTAGTCCC AACTGTTCTT TGTTCCCCTT CTTTTCCTGC

27951 TTTCTTTTAG ATTAGTCAAC TGTTTTTTAC GATTCAATTT TATATATATT

28001 TTTGGGTTTA TTAGCGATAA CTGTTTTGCT ATCTTAGTGT TTAGGATTTT

28051 TAGTATATAA TTTTAACTTA TCACAGTTCA CCTTCAGTAA TATTATACAT

28101 CATAGATGGT ATAAAAATTA CAATGATACA TTTTCATTTT TTTCTGTCCC

28151 AGACACTTCC TACCTGAATC TGTGAGATTA TGGTTTGTAT TAAGCATTAG

28201 AATATTTTGG GCCATTTTTT CTTTAATTTT TTTTCTGTCT CTTCTTTTTT

28251 ATTTGGGGAG TTATCTGTGA GCTGCTTGAA AGTTTCTTGC AGTTTATTGT

28301 GTCAAATTTA GGAATTTTTC CTTTGTTATC TCTAATTTGT GTTTATTTCC

28351 ATCCACTATA GTTTTTACTT CTGACAATGT AATTTGCATC TCTGCAAGTA

28401 TGGTTTGTTT TTTTTTTTTT AAAAAAAAAA ACCTTCCCTG CTTCCACTTA

28451 TTGTCTTGAG TTTTATTTGG AGTACAGAGA TTTACTTAAA ATCTTTCCAT

28501 GCTTGCTTTT AGATTTGGGG TAATTCCTCA CTCCTGAGAC AAGACCTTTC

28551 TGAATATTCA TTGTCCTGTG AAGTATGTGG TATTTTGGCC TGGCTCATGG

28601 GAATGGACGC TCTTCCAGTC ATTGTGTGAA CCCCAGACAT AGTTTCTGCT

28651 AATTTTCTTT AACTTTTTTT AAATTTTATT TTCCATTGTT CTTAGGAAGT

28701 TTCCTAGCAC ACAAGCACTT TTCATTACTC CACTAAATAC ACAAGAGGGA

28751 ATCTCTGCAC ACCTCCAGGA TTTGTTTCCT GTACTGCTTT TTTCTCTCCA

28801 GTTTTCTGTC CTGTGATCTC TATCTGCTTT GGTTTTCCTA GCCTCTCAGC

28851 TTCATCACCC CAGCTCTATG TCAGATTTTC TCCCTTTTTC ATGGCCTTGA

28901 ACCTCTGTTA AAACTCTGTC AAAAGAGCTG GGACATTTGT AATGCCTGCT

28951 ATATTTGTTT TCTGTCTTTC AGTGATCACC TACCATCTTC ATTGCCTGAA

29001 GTCCACTGTG TTGAAAATCA TTGTTTAATG TATTTTGTCT GTTTTGTTTT

29051 TTATTCATTT AGATAAGATG AAAAATCAGT ATCTGTTACT CCATCAGAGC

29101 TAGTAACAGA TTGCAGCAGA GCTTCAGCAC AGCACATGCT GCAAACCGGC

29151 CAGAGTGATT TTCTTTCCTC TTTGCTTAAC TGCTTCTTTC TCATCCTTCA

29201 TTTCTCAGTG TAGCATCTCT TCCTCACGGA AATCTTCCCT GGATGAAGTA

29251 TAGATCAAAT TATCTTATGC AATCATATAA CTATGGTTTG TGTTTTTTTT

29301 ACAGGACCCA TCTGAGTTTA TAACTGTCAT CTTTTTATCT TGGTTCTTCG

29351 CTATACTTTA AGCTAAAATA ATAGCAGAAG TGTTGTCTTA TCTTCAGAGC

29401 TTATTATAAT ATCTTCCACC TTGTAGGCAC TCAATATGTA CATACTTGTT

29451 CAGTGTCTGA ATGAATACAT GTTAAAAATG CACGGTCCTT TATATCCAGA

29501 AATCTACTCA TGTATTTTAT CTCTACTTTG CTTTTTCCCA GTTACAGATT

29551 GTGTTCACCT ATTGAAAATT AAAAATACAT TTTGTTTGTG TAAAAGATGA

29601 ATAGAACTTA AAGAAAATCT CTGTGAGCAA CTTGGAGTAA AAATTCAAAA

29651 AAATGAAAAA TAAGGCTAGT GTACTACAAA AGAGACTATC TGAAAAAGAA

29701 GAAATAAAAT CACAGTTAGA GCATGAAACA ATTGAATTGG AAAAAGAACT

29751 CTGTAGTTTG AGGTATGACC TAGTTTTAAA TAAATGTTTG AACTATTTGT

29801 TTTATATTAA AGACATATAA GGAGAGGTTT TGTAATTATG AACTTTCCTT

29851 CTAGGATTTA ACAAGGAAGA AAGCTTCTTA ATCTTATAGA GTGTGAAATT

29901 ATTGGATATA ATATCACTAG TTCTTAATTG TGAATACTTC TCTAATAATT

29951 AAATGCATAT TCTTTTAAAT CATAGTTTTA ATGGCTGTAT AGAATTTTAT

30001 GCTTTGGAAA TCTCATTATT TAATTGATGA ATTGAATTTT AGGTTTTAAA

30051 AAGTTTTTGT AATAATGCTA CAAGGAACAT CTTTTATATA CACATAGTTT

30101 TCTACATTTC TAATTATTTA CCTTGGATAA ATTCTTCTGG TTAAAGTATA

30151 GACACTTTTT TAGATCTGTT TTACATCTTT GATCAATATT TCTAAATTGT

30201 TCTTAAGAAT GTTTATATTA ATTTATAATT CAACCAACAG AGTATAAAAC

30251 AGATATTTTT CTTTACACAG AATAATTATT TTAAAAACTA TCAGCCAGGT

30301 GCAGTGGCTC ATGCCTGTAA TCCCAGCACT TTTGTAGGCC GAGGTGGGCA

30351 GATCACGAGG TCAGGAGTTT GAGACCAGTC TGCCCAACAT AGTGAAATGC

30401 TATCTCTACT AAAAATACAA AAAATTAGCC AGGTGTTGTA GTTGAACCTG

30451 TAATCCCAGC TACTCAGGAG GCTGAGGCAG GAGAATCACA TAAACCTGGG

30501 AGGCAGAGGT TGCAGTGAGC CAAAATTGCA CCATTGCACT GCAGCCCAGT

30551 GATAGTATGA GACTCCCTCT CAAAAAAAAA AAAAAAAGGA ATCCAGTTTT

30601 ATTGTTAATA TGCAGGGAAT AAAAAGTAAA ATAGAAAGTG ATTACTGATT

30651 AGCTTATTCA ACATCTCTGT CTCTGCTATG TAGATAAAAT TAATTCAGTT

30701 TTATGCTGAA GACATGTATT ATTCTTTATT GTTTAATTAA ATATTAGATC

30751 TTGTGTTGTT CCAAAACATA TTTTAAAATT GGTTATAAAA TACATACTAA

30801 TCAATAGGAT AGACTGGAAG TGTTACCCAA AAAACAATCT TAAAAAGTGT

30851 AGGGTAACAT ATTACATTCT TAACCTAGTC TTGGATTACA ATAATCTGTA

30901 GATATGTTTC ATAAAGACAT CAAAAATGCT ATCTTACAAT ATAAATTATG

30951 TTTAGGGATA CTTGCAATGA ATGTTTCATG AAGATGAAAA TGTATTTCTA

31001 GTGAATGTAT CAACTTGTTT ATAAAAAGTA ACTTTATGTT AATTAACTAA

31051 ATGATTCATC CTAACTGAGG AGTAATTACT GTGTGAAGAA AAGATAATTT

31101 TTATCTTGTA ACTTTACTGA ATAATTTTCA ACATCCTTTT TCATACTATT

31151 TGCTGGAGTT ACTAGTAACA GAAACTTATG CAGGTTGTTC TTTTATCAAT

31201 ACATTTCAAC TTACACATGT CCTTTGGATG AGATTGAGGT GAGAAACTAA

31251 AAACATGAGG ACTAGAAAGA AAAATAATAT TTAAGAACAT AGAAATTTCT

31301 TTAGGATAAT AAACCAACAT ACGAATGTTT TCTAATATCA ACAAAGAGAG

31351 TCAAACTCTG TAAGATATTT GAAGAGATTT ATTCTGAGCC AAATATGAGT

31401 GACTGTGGCC CCTGACACAG CCCTCAGGAG GTCCTGAGAA CATGTTCCCA

31451 AGGTGGTCGG GGCGCAGCTT GGTTTTATTC ATTTTAGGGA GGCATGAGAC

31501 ATCAATCAAA TACATTTAAG AAATACATTG GTTTGGTTCA GAAAGGCAGG

31551 CCAACTCAAA GCTGGGGCTT CCAGGCTACA GGTAAATTTA AACATTTTAT

31601 CGTTGACAAT TGGTTGAGTT TATTTGAAGA GCTGGGATTA ATGGAAAGAA

31651 ATGTTCAGAT TAAGATAAAT GATTGTGGAG ACCAAGTTTT ATTGTGCAGA

31701 GAAATCTCTC AGCAGACTTC AGAGAGAGCA GTTGTAAAAT GTTTCTTATC

31751 GGACCCAAAA GGGTGCCTGG CTGTTAGCTG ATTATCCCCT GGATCTGCAT

31801 AGAAAGGAAG GAAAACAAAG GGGAAAGGGG GTACTCTATG GAATGTGGAT

31851 TTTTCCCACA AGAGACTTTG CAGGGCAATT TCAAGGCATG GCAAGGAAAT

31901 ATATTTTGGA TTAAATATTT TCTTCCTTGT CTCATAATGT TATGCCAGAG

31951 TCAGATTGAA AAGCAAGTCA CAATATACAG GGTCAAATAA AACCCATCTG

32001 ATGAGAATCC ATGGTTTGTA GAGCATGACT CCCTGGACCC CTTAGGTAGG

32051 AATTTGGGCA AGATAAAAAA TTAGAGCTTA GTTCTCACTG ATAAGATAAA

32101 TTCTAAGATA AGTATATTTA CAGATTTGCC ATGCAGCAAG GAAAAAAAGA

32151 AAAGAAGAAA TGTTGAAGAG TTGCACCAAA AAGTTAGGGA AAAGTTAAGA

32201 ATAACAAAAG AGCAATGGAA GATAGAAGCT GATACGACAA AACAAATTAA

32251 ACCGGCTCTT GAATCAGTGG AGGTGGAATT AAAGACAGGA GGAAATAATT

32301 CAAATCAGGT AAATTAATGT TTCGTAAAAC TTCATATTTC TACTCATTAA

32351 TATTACTTAC AATATCTCTT TCATTTAATG TATATTATTT AGACCTAAAC

32401 AGTCCCCAAA TTTTATTTCA TCTTAAAAAT GAATCATGGT GGGCCGGGCG

32451 CGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCG AGGCAGGCGG

32501 ATCACAAGGT CAGGAGATCG AGACCATCCT GGCTAACACG GTGAAACCCT

32551 GTCTCTACTA AAAATGCAAA AAAAAGTAGC CAGGCATGGT GGTGGGTGCC

32601 CGTAGTCTCA AGCTACTAGG GAGGCTGAGG CAGGAGAATG GCGTGAACCC

32651 AGGAGGTGGA GGCTTGCAGT GAGCCGAGAT CCCGCCACTG CACTCCAGCC

32701 TGGGCGACAG AGTGAGACTC TGTCTCAAAA AAATAAAAAA TAAAAAATAA

32751 AAAATAAAAA AAAGAATCAT GGCATTTATA GCTACAATTA TTTATAATAA

32801 ATCTTGAAAT ATTTTATTTT AGTTCAAAGG CCTTATGGAA AGCAATGCTA

32851 TTCTATAATA TATACTTAAT GATATTGTAA GTATTTTGTT CCTTGTGACA

32901 TAGTTCAGCA TATTTTCCCC TATTTCATGT TAATTACGTT TCAAATGTTA

32951 TGGAAAAGAA ATAAAAGTTA TCCCAATAGT AAATAATCTC ATGATTCTCT

33001 AAAAAGAGCT TTATAAATTT AATTTTCTTG CCTTTTGGTG TCTTGAAATA

33051 GAAGATTATT TTTGTATGTA TGTATCTACC TCACAGAAGT TATTGATTTG

33101 GTGGAAGAGC ACTAGGAGTA GAGTCAGAAA AGCTGGGAAA AATTCCTGCC

33151 AGCTTCCCTT AAATTTTTAA CCTTTTGCTA TAGAATTATA ACTAAATGAG

33201 TTCATTGATT TGTGTGTGTA AAAGTGCTTA GTACAATGCC TAGACTTATC

33251 ATTTATCAAT AAATATCATT CTTAAAACTG ACAATAAAAA TATTAGAAAA

33301 GTAGAATATC TAGACAATAT TTTAGAAAAA GGGAGCTTAA AGAATTTGGA

33351 AAATGTCATT CATCTGTCCA AATGTCTGCC AAGCTACGGC TCTCACTACA

33401 GGGAGAGGTA TAGTTTAGAT GTTAGAGTGT AAACCCAATT TTTTAATGTG

33451 GTCATAGTTA TTAATTCTTT ATGCCTTGCA AATTGTTGTA ATTCAGTAAA

33501 AGCCTTTGTT CATCCTGAAA ATTTAAAAAA ATTATCTAGT GGTTTTTTTT

33551 TTGCTTTCAT GGATTCACTG TCTTCAAATA AACTTTTGAA CTTTGGGGAA

33601 TTTATGCCAT ATGAAGTTTG AGGTTTTGAC TCAACTTCTT TTTTCCCATT

33651 TAGATATACA GTTATGGCAA CCTCTCATTG TATAAATGTA CGGGTTATTA

33701 TTTAATTTCA GAAACAATCA CAATATGTTA TCCTATTGGA TACTAGTTAC

33751 AAGTTTTCTT TGTTTTATTT AGATTTCTGA AACTGATGAA AAAGAAGACC

33801 TGCTGCATGA AAACCGCTTG ATGCAAGATG AAATTGCCTG GCTCAGGCTG

33851 GAAAAAGACA CAATAAGAAA CCAAAACCTG GAAAATAAAT ACTTAAAAGA

33901 CTTTGAAATT GTGAAAAGAA AGCGTAAAGA CCTTCAAAAG GCTCTAAAAC

33951 GGAATGGGGA AACAATTAGC AACAATGATA GCCTGTTATA GTGGACAGCT

34001 TGCGTGCTCT GACAGATGAA AACACAACGC TGCATTCCAG ACTGGAGAAG

34051 CAAAGAGAGA GCAGGCAAAG ACTGGAAACA GAAATGCAAT CATGTGGTTG

34101 TAGACTGAAT GCTGCCTCTA TGTGATCATG ATCAAAGTCA TTCATCACGA

34151 AAGAGATCAA GAGCTTGCTT TCCAGGGCAC AGTAGATAAA TGGTGTCCAT

34201 TAACAGGAAA ATTTGAATTT TTGATCCTGA TTCTTTTCTC TGCAACTTTT

34251 CCAAAGCTGA GAGTAAGTCC AAGAGTCCTC GAAACTTGAG CTCCATTACA

34301 CAAGAGAGGC TCTGAAAGAA AAGGCTTTGG TTTTTGAACA CGTGCAAAGT

34351 GAGCTAAAGC AAAAACAGAG TCGAGTGAAG GACACTGAAA AAATGTACAA

34401 AAGTGGATAC AGTACAATGG AAAAATGCAT AGAAAAGCAG GAAAGATTTT

34451 GTCAACTAAA AAAACAAAAT ATGTTGCTTC AACAGCAATT GGATGATGCT

34501 CGCAACAAAG CTGACAATCA AGAAAAAGCA ATACTTAATA TTCAAGCCAG

34551 ATGTGATGCT AGAGTAGAAA GCCTTCAAGC TGAGTGCAGA AAGCACCGTC

34601 TTTTACTAGA AGACAGTAAA AGGTTGGTCA ATGGATTGAA TCATTTGAAA

34651 GAAAAAGAAC GTCAATATGA AAAAGAGAAA GCAGAAAGAG AAGTAAGTAT

34701 CAAGAAAAAT AAGTATTTTT CAAACTTCCT GAAGCACAAT TTAAAGTAAT

34751 ATTTGGTTAC AGCTGAATGG TGGATCTAGT TGAATATAAA AAAGGATACA

34801 TATGATAAAT ATATCTGCTT AGAAACATTC CTTGTTTCCA ACAAGTCAAA

34851 GTTAGATCTG AGAGATGTTT TCCTCTGATT AAAGTCAATG TGTCACTTAT

34901 AAAATTTTAA GTTATAAAAT GTCAATATAG ACTAATAGTA ATAATATAGG

34951 TCATACTACT GAAATAATAA TTTTAATGTA TTTATGTTGC AACATTTTAA

35001 GACCATGATA AATCAGATAT ATGGAAATGC TCATACCTAA AATGGTATTT

35051 TGAAGTTGAT TCAATAAAGT GCGGTCCTTT GACAGTTAAT TTCAGATTTC

35101 CTAGATGAAC TGAAGTGTAT TCCCTATTTC ATAATTACTT TTCTTCAGTA

35151 GCTTTAAATA TGTCTTAGTT GGTAAAATTT TGTTTTTCTT CATGTCAGTT

35201 TGACTTAAAT CTCTAACTAT TTCAATCTCA AGTTATGTAT AGAAATGATC

35251 ATTCTATTCT TCAAAGGCAT CTAATTTTAC TTATAATATG GGGAAAATGC

35301 AGTAAATTTT AGCCCAAATA ATATTTGATT TAATCTTCCC ACTGGCATTT

35351 ATAAATTACT TTCATTTTTA AATAAAAAAT TTGCTCATAA TTTTTATTTC

35401 AAGGATCAAT TACTATCATT TGGATATAAC TTTGTTCAGG ACAAAAAGAG

35451 GCATAGCTAT CTGTGATTTA TTAGTTTGAC ACTGGATCCC CATTTTCAGA

35501 CTAAGGAGGA TTTCAGACTA ACGAGGAGTG GCAGGACTCA GAGTAGGAAT

35551 GGAGTGAGTA GGGAAGAGAG ATATAGCAGC TGAGTCAGGT GTGGGAGGTG

35601 GAGGGCAGGT TAATTAGAGC ATCTAAGGCC ACTGTAATTT TACTTTTCTT

35651 CTGAGATAGA CATCTATTGG AAGGATTTAA GCAGATGATT TAATGTGAGG

35701 AACTCTGAGG TTGATTTGAG TTTCTAATAA AAAGAAAGAG GGAAATCATT

35751 CCACAATGTA TAATTTACTA CCATCGGTCT CACCCACATA CTCATTTCTT

35801 TTTGAGACTT CAGGTTTTTA AGCATTGCAG ATTCATCAGG GGAGGAATGA

35851 CTAGTGGGCT GAATATGTTG TGTGAATAAC AATACCAGTT TGGCAGGAAG

35901 ATAACACCTT CTGTATCCTT ANCTGGATTC AGTAATACAC AGGAATGTGT

35951 ACACATGAGG AAAAGAAGGT GAATCGATCT GTGTGGTGAT ATTTTTCAAA

36001 GTGTATGCTT TAGAGTTAAA TATTATTAAT GGTTTAATAA TAAGGTGATT

36051 TGTAAAATCA GTAACAAAAA TAACATCAAG TAGCTGTGAG ACAGCTTCAA

36101 TGAAAACGAG ATGATGTCTT AAACAAACAA TCAGCAACAA AAGCTTTGCT

36151 GGATGCTTCA TCGCGTCATT GCATCTATTT AGAAAATGAG ATGCAGGATT

36201 CAAGGAAGAA ATTAGACCAG ATGAGAAGTC AAGTATGTAT GAAACTTTGC

36251 ATGCCAACAA CTGTTAATCT GTAGCTAGTT AACTAATATA AAGTGTTTTG

36301 GGGTACTAAT TTTGGTGGAT GGCTTTCTTT TGTATTTTTA TTATAATTAA

36351 TTTTATTAAA ATTTTATAGT GGATGGCTTT CTTTTGTATT TTCCTTATTA

36401 TTATTTTTAT TAAAGTTTTA TTATAATGAA CCTATATCTT AATCTCTTTT

36451 ATTCTGCCAT TTTTTATACA TATTTTTTTC TTAAATATTT AACCTTAGGA

36501 AAGTTGAGAA TTATGCATCA TTTCTCACAG AAGTTGAGAG AGTTTTTTTT

36551 TTTTTTTTTT TACCTGTTAA ACAGTCTATT TTTAATGATT TCTCTGTTGG

36601 CATGGTGAGG CAAGCCAGAT TAATTCAGAG GACAATGTCT AATGGAATGT

36651 TTCAGAAAAT TATCTTATTT TTAGTCTCTA CTTTTCTGAA CGTATAAAGA

36701 ACTTGTGTGT ACTTATTTCA TAGATTTCAG GTTAACTTGT TCAGAAAGGC

36751 CATTTTACTG AATAAATTTT TATTATGAAG AAAATCCTTA CTCTCTTTCT

36801 ATTGGGCTCA GAGAACACAT TTTGTCTCTA TATGAATAGG ACAGTTAGCA

36851 TTTGCCAACA TGTATCTATT TTCTCTTATT TATAGAAAAA GCTAAACTAA

36901 AAAGGGGGTT ATAGAAGGTC AGCAAAGGAT GAGTTGAGAT GTTCAGGGTT

36951 GGTTAAGTGG GCATTTAGAC AACAAGGTTT CTCCTTTGGC ATGTTTAATG

37001 GACATCTTTG CAGTTTAAGA TGACGCTTTT AAATTACTTC TCTCCTAATG

37051 ATGACTTGAG TCCTGCTATT CAATGGGAGA GTCAATAAGA TCCTGTAGGA

37101 TCTTATTTGG AACTGACTTT GTCGATTTTA ATTTTGTTCC TGCTTGTTTT

37151 TAAATTTTCT TGTTGTTTCC CTAGAAAGGA AAGATGTCGC TTAGTTTTAA

37201 ATATTTAAAA ATGTGCAAGT TGCTTTGCTA TAATAAAACT AAATGCATAC

37251 ATACAAAAAA TAAAATTATA GTTGATGTGG TAGTGTTTGG AATTCAAAAT

37301 ATAAATGCTT AGCGTGAGGT AATCCTTTAT CTTTCCACAT TTTACCAGTT

37351 TGCAAGTTTG AGTATTTAAC TGATAAAATG TAATTCAAAA GCAAGAAGAA

37401 TGTGTTTTAG TCCTAGAGCA GGGGTCTGTG AACTTTTCTG TAAAGGGCCA

37451 GATATTATTT AAGGCTTTGT GAGCCATAAT ATCACTGTTG CAATAACTCA

37501 GCCCTGCAGT TATAGCACAA AAGTAGCCAT GAACAATATG CAGATTGAAG

37551 GGGTGTGGCA GTGTCCCACT AAAATTAATT ACAAAAAACA GGTAATGGGA

37601 TGATTTATCC TAGATTCTGA CCTTTTTTAA ATAAAAAAGA TTGTGATAGT

37651 CTAAAATATT TATATATATT TTGTTGATTC ATTCATCTAC TGATGGACAT

37701 TTAGGTCATT TCCAAATGTA ATTTTTTTTT AATTCTNTGT TTTAGTTTCA

37751 AGAAATACAG GATCAACTTA CAGCTACTAT AAGAAGTACT AAGGAGGTGG

37801 AAGGTGACGC ACAAAAGTAA AATTTGAAGC AGCACACAAA ATAACTTGAG

37851 TATTTATAAA GCAAAAGAGC ACTGTAGTAT GAAAATTGTA TCAGTTATGA

37901 TAATAAGTAT GTCTTTGTGA AGCCAAAAAA GTTTCATCTG TAAGCTATAT

37951 TGAAATACAT CATTTTTCTA CATTATTCCT AAATTTTGCA TATTATCAAA

38001 ACACAGGTAG AAAAATGACA GTAGCCCAGT CATCTACTTT TGCAATTGCT

38051 AAGAATTTGT GTAATTATAC CTTCAGAAGT TTGTTTAGAA TTTACATGAT

38101 TTAAAAACAA TTATGTGTGA GAGTAATTAT TTTAAAATGC ACATTTTAGG

38151 CTTGAAGTAG AAAATGCCAT GATGAGAAAA ATGATTGyAA AAAACAGGAT

38201 GACCAAATTG AGTGGCTTGA GAAAATCCTG CAGCGTTCAA GTTTGGTAAG

38251 CTGATCTCTT AATTTCTGTC ATACTGAAAA GGAATTTTAT TTTTCCAGTA

38301 GGATGGGTTA AATATCCCTT GTCCAAAATG CTTGGGACCA AAAGTAGATT

38351 TTTTCTCAGA TTTTGGAATA TTTGTATATA GCTAATGAAA TAGCTTGGGG

38401 ATGGTACCTG AGTCTAAACA TGAAATTCAT TTATGTTTCA TATATACCTT

38451 ATGCACATAG CCTGAAGGTA ATTCTCTACA ATGTTTTACA GTAATTTTTT

38501 GCAGGTAACA AAGTTTTTAC TGTTTTCACC AGAGCCTGTC ACATGAGGTC

38551 AGGTGTGGAA CATTGCAGTT GTGGTGTCAT GTCCGTGCTC AAAAAGTTTC

38601 AGATTGTAGA GCATTTTGGA TTTCAGATTT TTAGATTAGG GATGATCAAT

38651 CTACAGTACA GATGCTCCTT GACTTACAGT GGGTTTACAT GATAATGTTT

38701 CTTGTTTGAC TGAAACATTA TAAGTAATAT TTGATTTATT TCAGATGCTG

38751 CAGGTGTTCA AGAGCTAGAT GAAGGTATGC TGCCAAATTT ATGAATTAAT

38801 TCAATCATTG ATTTCTTGAA ATAAACTCTA ATTAATGAAC GGTATTCCTC

38851 TCAATTGCTT GGTTAATACA TGCTACATTA AATATTTTTT CTTATACACA

38901 TCTAGTGAAA GATGTGAAAA CATAAACATT CATAGTGAAG GGTATACTTA

38951 TGCTTTGTTA CTTCGTCATG TTCCATGGCT TTAAAAAAAT CACAAGAAGT

39001 CTGTGTATCT CTCTTTTTCT GGCCCTACAC TTTTCTTCTG CCACCCCAAT

39051 AGAACTGTCA GCCTGCACAC TGAAACTGTT CTCAGAAAAC AAAGGCATCA

39101 TCAACTTCTC AAGGTTAAGG TAGTGATTTA AGCTAACAGA CCCCACACTC

39151 ATGTGATAAT AATTGGTTAA GCAATTACAG GTCACAAGCA GTCACTTGAC

39201 CAGTGACATT TTAAATCTCT AGTCATTGAC TTTGTCATTG GTTTACTTTT

39251 GCACCTGGGA AAAGTTGAAA ATTCCTTAGC ATGGAATCAA AACTCTCACA

39301 TCAGTGTGGT TCTTGTCAGG TTATTCAGCC TTATCTTTCG CCACTTACCA

39351 TACTCTGCAA CTTTGTTCTA GCATCCAGAC AAACTAGACT ACACGGAGCT

39401 CCACAGTGAT CATCCTCACC TCCAGCTCTT TGCATTGACT TCTTCCCTCT

39451 ATCCTACATG TGTTTTCCTT CCCCTTCAGA TATCAACCTA TGAATTGCCT

39501 CTACCAAAAA GCCTACAATA TTGACACAAA CCTGGGCTAG TATCCCTTCT

39551 ATGTCTTCCA GTAAGTGGCG TCTTATGCCT GTCATTGTAC GTATGACTCT

39601 GCATGGGAAT TGCCTGTTTG TTTTTTCAGA TTATAACATA CAGTTGTTGA

39651 GGGGTGGACC GTATCATCTT TATCGTGTTA TTCCAGTGCT TGTCCTAGTA

39701 CCTTAGCACA TGGTTGCTGA ATACATGAAT GAAGAGTGAG AAACCAGAAG

39751 CTCTGATACT TAACTGCCAT GATAATGAAT TCAGTGTGCA ACTATGGGCG

39801 AATTATATTT AATAGTAATT GCATATTGTA CATATTTTTC ATTCTAATTA

39851 ACACTGATAA ACTTTTCAAC TTATACTGAC TTTCTCTTAG TTAACTGTGA

39901 AATCATTTAG ATAAAGAATA TAATCCTTTT TCACTCTAAC TTCTGAATTA

39951 TAATCTGAAT CCTCTATAGC AGGGGTCCCC AACCCACAGG CCACAGTCAG

40001 GTCCATGGAG TATACAGTTT AAGACCTCTG CTGAACAGCT ATACCTCCAT

40051 GCTTGTTTCC AGTGGCCATG ACACTTTATT TAAATATGTA AGTTTTATTA

40101 AGACTGAGCT CTTAAAAAGA AAAAACCAAG AACCTTAGAT ACAACTAGTG

40151 AAGAATTGAG ACCTGTCCAT ATTTAAAACC AAGCACACGA TACCACTTAA

40201 AAGGTTCCCC AGAAAGCCTC TATCCTGAAA TGCTTGAAAG TGAGGCAGTG

40251 CTGACTCTCG ATTATTACCA ATTGCATTAA ATATGACACT TGTTTTGTTT

40301 CTTTT~GGCT ATAAGGAGAA AATGTCATTT TGTATATGAG TGAGCACAGA

40351 GGAGAGAGAC TGGGGGAAAG AACAGAATGA GCTAATAATT TTTTACTAAA

40401 TACTCCAGTT CTCAGCTTTT TAAATCAACA GACAAAATGA ATCAGCTAAA

40451 CCTAAAATCT TTGTGAATAG TATAAATTGT CTTTTAAATT AAATGCATAT

40501 ATTTTTATGT TTTACTTTTT CAAGACAAAA GCAGGATATT AGTACAATAT

40551 AAGATTTATA GAGGAGCAAA TTTCTTGAGA TAGGAAACCC TTAAAAGCAG

40601 TATTTAAAGT GCTTAAATAC TGTCACATAT GTTTAATAAT CATAATACTT

40651 AATTGTGAGA ACTGGGAGCT CATGTTACTA CTAAAACCAA ATAAAAATTC

40701 AATACATATT TGTTAACTCA ATTTAAGGAT GTTTACCTTA ATACTGACAA

40751 AGTACGGATG GTAACACTGC CACACTGAGA ACAGGCAAAG TAATCTTCCT

40801 TCTGCTCCTT GGCCAAAACT GCCACAAACT ACACACATAT CCTGAAGTTA

40851 AGAAAGCAGA ACATATTTTA AATGGAGACT AAGCTAAAAA CCTACAAATT

40901 TACTTTAAAA ATACCTTCTT AACTAATATA GCTCTATAGC TAAATATTGG

40951 ATCACTTCTG TGTAGATGAG ATAAAGCAGA AATGTGCAAG GAGGAATTCA

41001 ATGAGGAAGA CAGTAAATTG TCAAGTTCAA ACCTGATTCA AAGTGAACTT

41051 GTCACTGCTA GAAAACAACA CAACCGTAGT GTGCATAGAG TTTTCTTCAT

41101 CATCCTTATT TGATGAAATA TCTGCAGTAG ACACCTATAA AAAGCAAAAT

41151 ACACAAAATA CGAAGTTATA TTTTTCACTT GTTTTACACT TAACTGAAAA

41201 GCTTCAGAAA ATTCATAATC AAAACATATA TTTTTGCTAA GGTCTAGAAT

41251 AACGATTCCA AATATTAATG CTAAGATACT ACAGTAAAAT GGAGTCATGA

41301 CATTTTATTA TTCAACTCAT TCTCTCTTTA GAGGTAGAAT TCTAATCAAG

41351 AAATTATAAA TGATAATATT ATAGGTATGT ACACACACAA ATCTATCACT

41401 ATTTTAATGA CACACACTTG GGATCTGCAA TGTAGTTAGT CTGAACTGAG

41451 ATGTCCTGCA AACATAAAAT ACAGCACATA ATTACATATT ACATGTTGAA

41501 ATGGTAATAT TTCAGATATA TCGGTCGAAA TGGAAGGCAT TAAAATTAAT

41551 TTCGTCTGTT CACTATAACC TTTATTTTGT TTCGAGAGGA GTTTCACTCT

41601 TGTTGACCAG GCCTGTTCTC CCTGCCTCAG CCTCCCAAGT AGCTGGGATT

41651 ACAGTTGTCC ACCACCATGC CCAGCTAATT TCTGTATTTT TAGTAGAGAC

41701 GGGGTTTCAC CATATTGGTC AGGCTGGTCT CTTAACTCCT GACCTCAAAT

41751 GATCCACTGC ACCCAGCTCA TTGTAACTTA TTAATGTGGC TACTAGGAAG

41801 TTTTAAATTG CATATGTGGT TCTCATTATA TTTCTGTTAG CACCGCTTTA

41851 GAATATTATT TTGAATAACA TCCAAATTTC AGTATTAGCC AAATGATTAT

41901 CAACCAATAT TGTTCAGTCT GGACTTAGTT CTATTTGACT AAATCAACTA

41951 AGTACCCACT GGTTTGTTAA TAATTTCTAG AGTGATTATG AAACAAAATA

42001 AAGCTCTGAA CTAGAAGTTG TAGAAGAAGA CAAGGAGGGC ACTGCCAAAA

42051 TCATAAAATA CAGTCCTCTT TCTTTAAAAA GCTTACAACC GAGGCCTGGA

42101 AAGACAGAGT TGAAACACAA CAGGTTATGT TCAAGGTCAA AAACATAACA

42151 CACCTGAATT ATTTTTCTTG AGGAACAATG GAAAGAAGAT TAACCAGCTG

42201 GGTGTAGTGG CTCATGCCTA TAATCTTAGC ACTTTGGGAG GCTAAAGTGG

42251 GTGGATTGCT TGAGCTCAGG AGTTTGAGAC CAGCCTGGGC AACTTGGTGA

42301 AATCCTGTCT CTACCAAAAA TACAAAAAAC AGCCGAGCAT GGTGGAACAC

42351 GCCTGTAGTC TCAGCTATTC AGGAGGCTGA GGCAGGAGAA TCACTTGAAC

42401 CCAGGAGGCA GAGGTTACAA GTGAGCCAAG ATTGTGCCAT TGCACTCCAG

42451 CCTGGGTGAC AGAGCAAGAC TCCATCTCAA AAAACAAAAA CAAAAACAAA

42501 ACAAAAAAAA AACCCAGCAA CCTTCAAAAT CAGAAACAAA TCAAACTCGA

42551 TGTCATCCTT TTTCTCTCCA CTGAGAAATG ACCACTGGTT ATCAAAAAGC

42601 ACTCCAATAT TTAAAGTGAT CTGACTCCCA GTCACAGCGT GACTGAATTC

42651 TTAGAAACAT ACAGCAGGTG TTAAGTATTT CTCTTGGACT GATTTATGAG

42701 AGAGGAAAGC CCTGAACATA TAGAAAATAC ATTTAAAAGC AGATTTTTTG

42751 TTTTTTTTTG GTTTGTTTGT TTTTGAGACA GAGTCTCGCT ATGTTGCCCA

42801 GGCTGGAGTG CAGTGGCGCA ATCTTGGCTC ACTGCAAGCT CTGTCTCCCA

42851 GGTTCATGGC ATTCTCCTGC CTCAGCCTCC TGAGTAGCTG GGACTACAGG

42901 CACCTGCCAC CATGCCAAGC TAATTTTTTG TATTTTTAGT AGAGACGGGG

42951 TTTCACCATG TTAGCCAGGA TGCCAGGATG GTCTCGATCT CCTGACCTCA

43001 TGATCCGCCC ACCTCGGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC

43051 ACCATGCCCA GCCTAAAAGC AGTTTTAATG GATAGTACTA ATGCTTTATA

43101 AGAGCAATTT ATAGTCATAT GAACCCTAAT GACTACAAGT GTTAATAATG

43151 CCAATATTCA TCATTAGGGA GTAAATAAAG CCATGACAAA TCCAAACATT

43201 AGAAAAGTAT GCAACATTTT AAAAGTAGGG AGGTAGAAAC TTGTATAGAC

43251 TGCCATGAAA GAAATTATCA AAGACACTGT TGAGTGAAAA AATAAATTGC

43301 AGAACAGTAT TTGAGGTATA GCACTATAAT ATAAAAACAT GCAAAGCCAT

43351 TACATGTAGT CTATGGGCAC ATATAATAGG CTGACTCATA AGAAATTGCT

43401 GCTTTTCATC AGTTCAGAAA TAATATTGGC AATTTCATAT GGATCAACCT

43451 AATATATAAA TATACCAAAC TGGTAACAGG GAAATAAGGA GGACTGAGGA

43501 GTTAGTAATG GTAAATTCTG ATATACCTAT AACGCTTTAA TTTTTTAATA

43551 GAGAAAATGT ATTGATGTGT TATATGCATA GCATTAACAA AATTAGCTTT

43601 CTAAGATTTT AGAGAATCAT CCAAGATGAT TCACAGAAGT AGAATCATCA

43651 TCATCAGTAA GAAATTAAGT GACTACTAAA AGTAATCATT AATTCAGTCA

43701 TAGGACTAAT GATGCATTGA CAAGGCTATT GAGATATATA ATTATGGAAA

43751 TGGCTAAAAT AGAGATAAAG GTATCTATTT CTACCTCCCA ACCACTAACA

43801 GAAAATTCAA CACATTATAC ACACTGAGCA GCTCAAAGAA ATTGTAAAGA

43851 TCCATTATTA TTTTTAAAAG GAAATTTAAA CAGTGAATGC TTTCACTGAA

43901 AATGATAAAC AATATATTCC CAGGATAAAC TGGAAATAAA GTCTGCAGTA

43951 GAAAACTACA AAGTCCCTAG ATTCAAGTGG GGGTGGGGAG TCATATTTGA

44001 ATAATAAGTG CAGAAAAACC AAAATATTTT AAAATAATTG TCCATGGAAG

44051 AAAGAAAACA GTATCATCTA GCTTGAAGAC CCATTGTTCT TATTTTATAA

44101 TTTATTTCAG ACCTTTAGAC TGTTAGAATA ATAAAACCTA ACTTGAGGGC

44151 AAAGGTAATC TTTGAGAAAA TATGTGCTAT TTTTGCCTGC ATAGATAATA

44201 GTGTGATTTA TCCAGAAGGT GATAGAAATA TCATTTTCCT AGACCACAGA

44251 TATAAGCCAA GGAGAACAGA AAGCTCTGAC CTAAACTTCA CAAGTGTCCC

44301 TTCCAAGCAG GGACATGTAA GAGTAAACAA AAAAAGAAGA TCAAATTAAA

44351 CTCAAAGTGG GAAAATAGGA AAAAATAAAG ATGAGAATAT AAATCAATAA

44401 AACAGAAAGG GGAAAGAAAA TAGAGAAAAG TCCATGAAAA CAAAGGCTGA

44451 CTCAAGAAGA TCAATAAGAT TGATAAATCT CTAGCCAGAC TGATCAGGAA

44501 AAAAATTAGA CACACATTAT TAGTATCAAG AATGAGGAAG GTGAAATCAC

44551 TACAGATTCT ACAGGTATTA AAATTATTAG AAACATTATG ATCAACTCCA

44601 TTCCTTTAAT TTGTGAAGAT AGACAAAATG AACAAATTTC TTGAAAGATG

44651 CAAATTTATG CAAGGAGAGA CAGATAACCT AAATAGGTAC CTATTAAAGA

44701 AATAAAATTT GTTGTTAAAA ACTGTCCCAC AGGCTGGGCA CTGGTGGCTC

44751 ATCCACTAAT CCCAGCACTT TGGAGACGGA TCACCTGAGG TCAGGAGTTC

44801 GAGACCAGCC TGGCTAACAT GGTGAAACCC CATCTCTACC CAAAACACAA

44851 AAATTAGCTA GGCATGTTGG TGCATGCCAG TAATCCCAGC TACTCAGAAG

44901 GCCTGAGGCA GGAGAATTGC TTGAACCTGG GAGGTGGAGG CTGTAGTGAG

44951 CAGAGATCAC GCCACTACAC TCCAGACTGG GCATGGTGGC TCACGCCTGT

45001 AATCCCAACA CTTTAGGAGG CCAAGGCAGG TGGATCACCT GAGGTCAGGA

45051 GTTCGAGACC AGCCTGGCCA ACATGGTGAA AAACTGTCTC TACTAAAAAG

45101 ACAAAAAAAG AAATTAGCCA GGCATGGTGG CAGGCACCTG TAATCCCAGC

45151 TACCCAGGGG GCTGAGGCAG GGGAATCACT TGAGCCTGGG AGGCAGTGGT

45201 TGCATGAGCT GAGATTGTGC CATTGCACTT GCAGCCTAGG CAACAAGAGC

45251 AAAACTGCAT CTCAAAAGAA AGAAAAAAAA AAGAAAACAC AACAAAAACC

45301 CCCCACAAAG AAAATTTCAG GCCAAGATGG TTTCACTAAT AATTTCATGT

45351 ATAATATAAG AAGATACATT TCCACTACTA CACAACTTTT CCAGAAAACT

45401 GAAGAGGAGA ATATACTTTC TGATTCATTC TATGAAGCTG GAGTTATGCT

45451 GATACCAAAA CCAGATGAAG ACATTACAAG AATGTAAGAC TACAGGCTGG

45501 GGAATGGTGA CTCATGCCTG TAATCCCAGC ATTTTGGGAA GCCAAGGCCG

45551 GGAAAATTGC TTGAGCTCAG AAGTTCGAGA CCAGCCTGGA CAACATAGTG

45601 AGATGCTGTC TCTATTAAAA AATTTAAAAA AGTAGTTGGG TGTGGTGACA

45651 CACACCTATG GTCCCAGCTA CTTGGGAGAC AGAGGTGGGA GGTCGAAGCT

45701 GGAGTTAGCT ATGATCGCAC CACTGCACTC CAGCCAGGAA TTATAATGAG

45751 AACCTGTATC AGAAAAAAAA GTGCACAGGT TTACAACCGT GGTGCATCCA

45801 GTTTTATTAA TAGCAAGAAC AGGGAGTACG CTGTTAAACA CAACAGCATA

45851 GATGAATCTC CAAATAATTT TGCTGAAATA AATCAGTCCA AAAAGCATAC

45901 AGTTCTGTAT GATTCCACTT ATATACAACT CTAGAAGATG CAAACTAATC

45951 TTGGGGACAA GGACGGATGG CAGGAGGAAT GCAGAAAATT ACAGAGGGAC

46001 ATGAAGAAAC ATTGGGAGAT GAATATATTC ACTATCATGA TTGTAGTATC

46051 GTTTTCAAGG GTGTATATGT ATATATCAAA GCTTATGGAA TTGTACATGT

46101 CAAATATAGC TTATATCAAC TATACCTCAA TAAGCCTGGT TTTAAAATTT

46151 TTCTTTTTGA AAAAAGGACG AGAATCTAAG CTTCCTTATT CCTGGTTTAG

46201 TAGTAAACTT TGAACAATTT CACCTGTCTC CTATACTTAA AATGACATTT

46251 CAGAATTTTA AAAACAGGAT TTTAATAAAA TAGCGAAGTT ATTACATAAA

46301 ATATTTGCTA GTAGTTAGCA ACTGTATTTG TAATACACAT ATAAATAAAG

46351 CCTCATAACA TGATAGTAAG CAAATATCAA TCTTAAAATT TTTTAAATAA

46401 AGGAGCAACT ATATTACATA CTGACTTTTT AGAAAGGGTT GGCATAGAAA

46451 GATAAGGAGT CAAAGAGGAA GGTAAGAAAA GAGGAAGGTA AGAAAAGAGG

46501 AAGGATGAGA AAGTAAATAT ACAAGAAAAT GTAACCAGTG GCTCAAAAAA

46551 AAAGCGAAGT AGGACAGTAA AATAAACATT TTGACCTATT TATATGACTC

46601 TTAAGTTCAA AATAACTTGC TATGAGATTT TCATCATTAA CTGACATTTA

46651 GATTAGATAA AATATACATG AAGCAAGCCT CACCCCAGGC AATACAACAG

46701 CTCCGATTCC ACTTTTCAGC TTTGACTTGC CTCGGCCACC TCGCCCTGAC

46751 AGTCCTGCAC CTCGAGGTCT CTGCTTTCCT GGAAATCCAG ACCCACGGCC

46801 CTATGTAACA GATTAGGAAA AGTCAACATT CTGTGTCAGC CCAAAATGAT

46851 TTTTAAATCC AAATGCCACT GAGATAAAAC ATTTTATTAA ATGTTATACA

46901 AACACTTCTT TAGATAAGTA TTAAGAAACC TGGCTTATTA TTTTTATCTT

46951 TAAAAGTATA CTGCACAACT TAAAAATCTA AATATAAAAT GCTTACAAAC

47001 TTAGAATCAT ACCTTAGGCC TGTCACTGTG AACGCTATCA GCAAGCCTTT

47051 GCATGATTTT TCTCTTTCCC ACTCCTACAT TCTCGGTGAC GACAACAACT

47101 ATAGCCTGAT CCAGATATTT TGAAGTGCAA CAAATTGTAT TCAATATAGA

47151 GTAAGGATAA GGAAGAACTC TCTCATTAAC TGGTCTCACG GTGATTACAG

47201 TAATAGCTAA CATCTATTGA GTGCTTACTA TGTACTAATC TAAGTATTTT

47251 TTACTCTCAA CAATCTCATA TAGTAGGTTT TATTATCCTT ATTTGAGATG

47301 AGCGTGCTGA GGAATAAAAT GGTTAAGTAA CTTGTCCAAG GTCGCTTAGC

47351 TAGCAAGTCT GGCTCCAGCG TCCCTGGGTT GAAAGCATAT TTGGACTGCT

47401 ACATCAGCAG AAATTTCGTT TTTGGCTAGT GTGTAACAGA TTCTTCCCTG

47451 TCATTAAAAA TTAAGTCAGT TTCCTTCACT ATTCCAACAG TTCTCTTATG

47501 AACTCAACAT TTCTACCTCA TTCACCCATT GTATTTAGAG GAAAATTTAT

47551 TATTATTGTT ATTACTTTTA TTTTTGAGAC AAGAACTTTA TCCATCACTC

47601 AGGTTGGACT GCCAGTGGTG TGATCACAGC TCATTGCAGC CTAGAACTCT

47651 TGGGCTCAAG TGATCCTCCT GCTTCTGCCT CCCGAAGTGC CAGGATTACG

47701 GGAGTAAGCC AAAGCATCCA GCCAGGAAAA ATTATTTGAG GATTACAGGA

47751 AAGCTGACAA AAGGCTTTGT GAAAGCTTTG CTTTAAATAA TCTGAATAAT

47801 AAATACTTGA AATGGAAATA ATTTATCTGA CTTCTTACAC AAGAAATAAA

47851 CCTATGGGAA AATGTGTTAA ATTCCCTGAT AATTTCAGAC ATTAAGTACC

47901 AGAGTATCGT GTTCCCTGCC CCCTCACCCT TGTTTGTACT AATTAATTAC

47951 TCCTTAAAGA AACCTGGCAC CTACCTAAGT AGATGAATTA TGTATATTTA

48001 AAATTATCCA GATGCTCAGG AAAATACTTA GACGTTTCCC TCACGACAAG

48051 TTAAACAATA TGTCATATAT TCAACTGATC GTCCCTTATC ATAGTTTGAA

48101 ATGAACTTAT TCCCTATTTA TCAGAATGGA CCCAAGTCAA AAATTAATGG

48151 TGATACTGTA AGCATTAAAT AGAAACACAT GAACAAAAGG AACGGGAGGA

48201 ATGGCTTTCT CCCTTTGGAT GTAATAAATA CAGCCAGCTC CCAGTTTCAA

48251 ACTGCCACTC CTGTCTTCTC TTACCCTGCT CTCCTTGAGA TCCCTTTTGA

48301 GAAGTGCATC AGCTTCTTTG CACAACAGAT GGATGGGGTC AGGTTAGTTT

48351 TTTGGGTTTT TTGTTTGTTA GTTTTTGAGA TGGAGTCTCG CTTCTTTGCC

48401 CAGGCTGGAG TGCAATGGTG TGATCTTGGC TCACTGCAAC CTCCGTCTCC

48451 TGGGATCAAG CAATTCTCCT GCCTCAGCCT CCCTAGCAGC TGGGATTACA

48501 GGCACATGCC ACCACGCACA GCTAAATCTC TTTGTATTTT TAAGTAGAGA

48551 CGGGGTTTCA CCACGTTGTC AAGTTTGGCC TCTAACTCCT GACCTCAGTG

48601 ATCTGCCCCC TCAGCCTCCC AAAGTGCTGG GATTACAGGC GTGAGCCACT

48651 ACCCCTGGCC GAGTTTGTTT TGTTATTAAA TTGGGATAAA AGAGTTTTGA

48701 AAAATTAAAT CAGTGATTAA AAATCAAGAC TACAGGTAAT TCTCTAAATT

48751 TATTTTCTTG AACATGAAAA TGGCTTGACC CAGAAAAAAA GTAAGTTAAA

48801 AATTGGTGGT CTATATTATC AAACTGTCAA ATGAGGTATA TTTATACCTC

48851 AATATCTTGG ATGATATCAG GGGGAGGTAG GGAGGTTAAA AAAATAGTTC

48901 TTCCAGTCAT GAAAGAAAAT AATCTAGAAT TCCTTAAAAT CCTTCATTAG

48951 GCTAAATTAA ACAGCCATAT TCCAGAATAT TAAATATAGA ATATGAAGAA

49001 AAACTGTCAT CTCCAGTCAA TGAAGTATTT TAACTTTTGA GTTAATACTT

49051 TTTCAAATTA ATTTTTTTAT CTTCAAAATG CATCACACTA CTTAACTCAC

49101 TTCAAGGACT GGCAGAGCCA TCAAACAATG TCATGGGGGA AAAAGCCTTT

49151 TAAGTCATTT TAAGGTATTA ATACAGACAA TGAAATCTCC CACAATTTTG

49201 GTATTTCTTC TCCATGAGAA CATAATAAAT TAATGGAGTT TTTTCTTTTG

49251 CTTTTTTCTA AGCAACAAAG TTTTATGATA TCATGAATGA AAAGGTCCTT

49301 AATTACCTTT TGGTCTCATG TCAAGGACTT CTCCCTCATA AAACCAGTAG

49351 TAATCACAAC AAAAGGAATT AACCATAAAA AGAGGTATTA AAAATGTATA

49401 CTTGATTTTT AAATGCAAGC ATATTATTTC TTTACATTAA AATTTTTAGA

49451 TTTAAAAAGT GTTTCTGGAA GCTCAATCTA GAAAAGAAAG ATTTAATTCT

49501 TAACATCCAG TAGGGCAAAA CAAATCAGAC AGAAATGATA TATGAAATGT

49551 AAATGCAATT TTATGTACCA CTTTGATGCT CCAAATGGCA CTGCCAGGAA

49601 GTGCCTGGGT TTAAAAATTT CCCGACCTCC TGAAATGTCT GGGGACCAGG

49651 AAGGTGGGCT CACTGTATTA TGGGTACTCC AAGCCTCCTA GGATATGGCA

49701 GTTGAGAAAA TAGATGTGTA AAACTCAGCA ACATAAAAGG TCAAAGCCAG

49751 CAACTAAGGA ATTTTAGGAC AGCAAAAACA AATGCAAACG TATGGAAATT

49801 TAGGACAAAT TGCTTCAAGG AAGGCAAAAT AAGCTAATCA CTAACAGTGA

49851 TTTAAACATT TAAGTATAAC AAATGTTTGC TGCTACAGAG ACATCACTAC

49901 AATGAAACAT TAAAAATTAA GGGTTTATAT GACATCAACA TTGACTCATG

49951 AACTGCAATT ACTGCACCAA GAAGTAAATA AAAGTCAATC ACACTTTAAG

50001 AATTGACACT AGAAGAAAGT ATTGGGGGGT TATTTTTCTT CTAACAACTA

50051 TCGCTCTACT TAAAAGGAGA AATGGATAAC CATAAGGGAT TCTATATTCT

50101 ATAGCTATTA ACAACCAAAA CCAGTAGGCC AAAGAATGCA ATGAGAAACA

50151 TAAGCAATCG ATAAATGCAT AAACTTTAAA CTGTAGAGAG CTGGTAACAT

50201 TAAAATGCAA ATACCATTAT AATCTTAGCA TTTAATCACT CTTTCTTCAG

50251 TGACCACTAG TTGTCGGTTT GGTTTCGGTT TTTACTTAGG GAAATGAATA

50301 CTTTATGGAA ATTACATCCA ATGGACAAAA GTGAAGAAAC GTTAAAGCAA

50351 ATTGTCCTAA ATTTGCAAAT TAAAATGCCT TAAGTGCCTG ATAAATTATA

50401 TAGAAAGTAG TATCTTATTA AAATCTATAT AACTAAAACT AAAGCGTTTT

50451 ACTTCCAAAC AACCACATTC AGCAATACCC TGAACTAATC TGAAGATGCT

50501 AAACAGCATA AAGAAAAATG TTTACTCCAC AAAAATAAAA TTTTAAAGAA

50551 AAACAAGACA AATGTCAAAC AATAAAAGAA TATATTTTGA CTTAGGTAAT

50601 TCAATGGTGC ATGCATAATT TTACCAATCA AGTAACCAAA ACTTAAGACA

50651 AGGTACGTAG TACTTACCAG GTTTCTAGAA TATCATCAAA TTAACAAGTA

50701 CTATCTCATT AATCACATGA AAATACCACC AGGAATTAAA ATAACCAGAA

50751 ATAAGAATGT GACTGACTAC TCTTGGGGTA AGAGATAGGA AATGGAATAA

50801 CAGTATTTTG AGAAAAGCCA CACAAGCAAT AGACTGGTTT CATTTTTAAG

50851 TCACAAACTC AACCCGCACA CATTGAAGTC CAGCAATCCA ACTCATTCTC

50901 TCCAGCAAAC ACTATTTTTT TTCCCTTCCA GGATTACCCT CAGGTGTTCT

50951 TTCTTACCCA TCAAATCTCT AACCTAGCTC AGGTAATCAC TATGCTGATT

51001 TCACTGAGCA GCAACCACTG CAGGTCAATT ACCTCACTTT CATAATTTCA

51051 AATCAACTTG AATCTGGCCT ATGTCTTCTT CCCTACTATT AGTAGGGAAC

51101 TGTTGTCAAA AAGCCATTTC TCTTTTATCA TTTTACTCAA GCTCCTGACA

51151 TCTGGCATAC TGTTCTGCTG GATTTGGCAG CAGCCCACCT GTGGATATTT

51201 CACTGACTTC CTCGCTAATC TTTCTTCATC TCCTGTACGT GTTCTTCGTC

51251 TATTTGACTT CCAAAGCCCT GGAGTTTCCC AGGGCTTGAG CCTAGATCCT

51301 AAATGGTATT ATCTACAATG AGGGCATCTT GGAAGTTGAT GCTTCCCACA

51351 TTCTTATTTC TGGTTTTAAT CAAAGATCTC CAAAGTAGCA GGATTTTCAA

51401 CTTCCTTCTT AGCATTTCCA TTTTCTCACA CAAAACCCCT CTTAAGTTTG

51451 CCAAGTTTAA AATTTCTCCC TTAACCGGTT TCATCCCAGT CTTCCCCATC

51501 CTTATAAATG GCATCCAGTC CCTTGTCACT CTCCTCTGCT CCTTCAGTCC

51551 TCTCCCCCAA CACTTTGTCA ATGCAAATCA TCAGCAAATT CAAGACTTTT

51601 TATCTTCAAG TTTTGTCTCC AATCCTTCTA CTTCTTGTCA CTTCCACCAC

51651 TAGCAGCACA CTCGTGGCCA CCACCATCTC TCACCTAACC TGCTACAGAG

51701 CCTACTGCTG GTTATGCTTC TCCCACCCTG CATATACTCA AACCTTTCCC

51751 CACAGCAGCC AGAGGAACTT TTCAAAAGTA CAAATGTGAT CAAGCAAGTC

51801 ACTATTCTAT TTTAAACCTT TCAATTGCTT CTCAGAGCAC TTAAAATACA

51851 AACCTTTCCC AGTGCCTTTC TCCAACTCAT TTTGTGGCAC TTGTCTCCCC

51901 TAGTGCTATG CTCCAGCTAT TCTGGCTTCC TTGCTGTCCT TCAAACATGC

51951 CAAGCTCTGT ATCAATCAGA GCCCAGCTGA CTCAGAACAC TTCACTATAC

52001 CATTCTGGCC CTTCAATAAA TGTCTGGCAT TTTCTTTCTT TCTTTTTTTT

52051 TTTGAGATGG AGTCTCACTC TGTCACCCAG GCTAGAGTGT GGTGGTGTGA

52101 TCTCGGCTCA CTGCAACCTC TACCTCCCAG GTTCAAGCAG TTCTCCTGCC

52151 TCAAGCCTCC TGAGTAGCTG GGATTACAGG CATGCACCAC CAGGCCCGGC

52201 TAATTTTTGT ATTTTAGGAG CAATAACATG TTGGTCAGGC TGGTCTCAAA

52251 CACCTGAGCT TGTGATCCAA CCAGGCTTGG CATCCCAAAG TGCTGGGATT

52301 ACAGATGTGA TCCACCACGG CCAGCCATGT CTGGCGTTTT CTAACCCTTC

52351 AGGTATGGCC TTACATATTT TCTCATCAGG AGACCTTTCC TTAGTGCTCC

52401 CAGTGAACCA TCATCTCTCT TACCACACCA TTAGTGCCTC TCATTGCATC

52451 ACCACCTAGG ACGTTTTATT GTTTGTAATT TTATTTAGTG GTAGGCTGTG

52501 GGGCAAGAGA TACCTAAATT ACTTCTCTCA ATATTTCCAT TGGTTTTTCT

52551 CTGAGATTTG GCTAACATAC ATCTTAAATT CTTTTTAGTC AATAGTTTAA

52601 TATTATGTTG GCAGTAGACA GTTCTAAAAA ATATGAGACA GAAAGTCATA

52651 CTCTAAGATA AAAATAATGT TGAATAATTT TATTTCAGAA ATAAGAATTT

52701 TCTGGTAATT ATGTATTATT CATCATAATT TAAAAGTTAG CTTTGATGCC

52751 AAAATTTTAT CTCACTTTGA AAAGACAGAC TTTGTGTAAT TTTATAGTTC

52801 TGAAGAAAAA TTATCATTAT ACTTAGATAT TCTGACAAAT TATCTAGTAT

52851 ATTCCTTAGA CCTTAAAACT AAAATATAGC TATAATTATC AAAGTTTAAA

52901 TTATCCTTCA GATCTTAGCT TTGATCAAGA ATTTACACAA ACCATTCAGA

52951 AAAGGTTACC TGCCCCTGTA ATGTATGGGC TCTTCTCCTA CAATCCAGTT

53001 GCAGCACTTT TTACACTGAA TTAAAGATCA TGCCCCTTTC TGTCCACTGC

53051 TACGTTAAGC ACACTGTTCA GCACTTACTG AACTTTTTTT CTGCTGAGCA

53101 TCTATTATCT TTTTTTGCAT GTGTGTATGA ATTCATCAAT AAACAATGAG

53151 CTATGATATG AAACACACTA ATGCCTCCAC CAGTAATAAC CTAGAATCTT

53201 GAATTTCTTC ACTTAAAAAA AAGTTACTAA AAATTACTAA AAAAATCTAT

53251 ATAATGCCTC CTTAATCTAC AAACTGAATT AAAAGCAAAA TAGTTCCTAA

53301 TGTAATCATT ATTAAGTTGT AAATAGAATC AACTTGCTAT CAAATACTAC

53351 AGAAACTAAA AAAACACTAC CTGGCAGGGA CTGAATTTGA ACCCAAGAAA

53401 AATAATTTAA CCCAAAAATA GTTTAATATT AGCATTAAGT TTCTTTCTGC

53451 TTTGAGGCCA ATTTCTCAGG TAAACTGTCC AAGCTAGTAA ATCATACAAG

53501 GACTGTGGGA TGGGGAAATG AGAACAATAA TGACAAGTGG AGGATAGGCT

53551 ATTTAGAAGC AACTTTCTAT TAAAAGTCAA ATTCTATTGC TGATTGTTAA

53601 ATACGATCAA AGTCATTCTT ACAGCCCAAG AGTACTATCA GTTTTAAAAG

53651 CAGCCATACA AGGTTTGGTG TCTCAAAGGC AAACTTTACA CCTCCAAATC

53701 TTAAATCAAC CCCGGCCCCA CACTCTTCCA ACATACTATG TAAAACCAAG

53751 GTTGCTTATA AACAGTAAGT CTAATTTAGG AAAAGTGAAA GCAATGAAGA

53801 CAGAGGGCAG AAAGGAAGAT AACTGGTAAA AGAAACAAAA GAGTTTACAG

53851 TTTGTCTTTT TGGTAAATAC AATCACTTGT ATACACTGGA GCTACAGCAG

53901 CAAACACTTC ACTCTTTAGG GAATTCTTAA AAGAAGTCTC ATATATAAAA

53951 TTGAGTTCAA TATCAAGTAG AACAAGAAAT TAGACCCAAT CCTGTTTTGA

54001 TAACTACAGG AACAGCTATT ATCAGCTTTA GCCTTCAATA ATTTCACAAT

54051 ACAAATTAGG TAGTGCTAGC AACAGTAATG TCTCCAAAAA TACCACAACA

54101 AGCACAAGTG AACTAAAAGC AAAGTCTGGT ACTTCTAATC TGCTGTGTTG

54151 TTAGCTTGGT GTTCCAAAGG GGTAGGTATT TTTTAGGTTT AACACTATGG

54201 TTCTCTGGCT ACTTTTAAAA CTGAAAGTAC TCTTCTTATA ATATAAAGTA

54251 AACTTCTAAT AATTTGTCCA AGAGATATCA AAATACAGTA CCTATGTTTC

54301 CATTTATGAA ATTTTCTTGA AATATTTACT GCAGGCTGGG CATGGTGGCT

54351 CACCCCTGTA ATCCCAGCAC TTAGGGAGGA CAAGGCGGGT GGATCACCTG

54401 AGGTCAGGAT TTCGAGACCA GCCTAACCAA TATGGTGAAA CACCATCTCT

54451 ACTAAAAATA TAAAAAAAAT TAGCCAGGTG TGTTGACGTG CACCTGTAGT

54501 CCCCGCTACT CAGGAAGCTG AGACAGGAGA ACTGCTTGAG CCAGGCAGGC

54551 AGAGGCTGCA GTGAGCGAGG TCGTGCCACA ACTCCAGCCT GGGTGACAGA

54601 GCAAGACTCA ATCTCAAAGA AATAAATAAA AATAAAATAA ATATCTACTG

54651 CAAATAATAC GTTTCATAAA ATGCTTAATA AAAACTTTCA ATACCACCAT

54701 GAAAGCAATT AGAACATGAG GGTGCCTGAA GTAGATCATA GTAGTGTGAT

54751 TACATTCAAT ATCTTTCTAT AAGACGTGAT GATACATACA GGGTAAATCA

54801 TACAAGAAGA CCTAAGATTA TTATCTCAGA ATTTCCTAAT TAGAATGGGA

54851 ATCAATTGTG CAATGAGAGA AATGGACTGA AGACAGAAAT AAAAACAAAT

54901 TTTATGATTT AATATGACAA ATTTAAAATT TCCACTTTAT TTTCCACCAT

54951 TTTTAAAGGG CATTCCTTAT AGTATTAATT TTAATGCATT TTTAAAAATC

55001 AGTAAGACAA GTAGCACATT TCTCTAGTTC AGGACTCCAC TTTCAGGGTT

55051 ACAGTTAAAG ATGATCCTAG AAGTGCATTT TAATTGGTCT AGGGGAGGGT

55101 CATTAGCTTG ATGTTCTAAA ATCTACTGAG TTGATTACAA TATGTGTCAG

55151 TGTCAATAAC CACTTT.CTT AAACCCAAGT CGCAAAGCAC ATATACCTAT

55201 AGAAATGTCG AAAATGGGCC AGGTGCTGTG GGGCTCACAC CTGTAATCCC

55251 AGCACTCTGG GAGACCCGAG ATGGGAGGAT CACTTGAGGC CAGGACTTTG

55301 TAAGGAGCCT GGTCTACACA GCAAGACCCC CATCTCTATA AAAAAATAAA

55351 AAATATTTTT AAATGCTGAA AAATGAAATA CTAAATTATT TATGAATATA

55401 TAACTTCAAT AAAAGATGAG AAAATACAAC TAGGTCATTA GGACAATTTG

55451 TATGAAACAA TATCCAATTT GCTGTCTGTT ACTTCTACCT TATCATGTCT

55501 AATTTTTCCT CATCTTTGTG AAATCCTGCA TCTACAATAG GCAAAAAAAC

55551 AAAAAACAAA AGGAATCTTA TTCTATTCAC AGCCATCAGA AAAATGTGTT

55601 ACTATTCCTG TAGTCAGTTA GGTTCTAAAT CATACATTTG AGATATATCT

55651 CAAACATGTC ATAAAGAAAA TAAGCATCAT ATTTCTAACT AAATAGCACC

55701 TGAAATATTC CATATGAAAG GAAAAATACG AAAAACTAAA CTTTTAATTA

55751 CTAACCTCCT TAAAGGAAAA TAATTCTATA TGATTTGATA TTTCATAATG

55801 GATGTCCAAT ACCTGAGATA TAAATTCCAT TTTCTGTGTC CTAACATCTC

55851 ACCTTCAGAA AATCTCCAAT ATTGGGTTAT TTGGATTATA TATTTAAAAC

55901 TGAATATACT TGAAGATGTG AATGATTTGT TGCCACAACA AATGGTTTAC

55951 AATTATCTGC ATTAAAATGT GTTCCATGAA CAACAGAAAA AGAATATTTC

56001 TACTTCAGTC CTTAAAAATT GTGAAAGCAC AGCCACAGTC TTAGTTTGTC

56051 GATCTTCAAT TCTTTTGGTA TTTTAATTTC ACCAATAATT CTGGAACTGC

56101 TGGTTTTGTA TTTCTCAAAA TGTTTGTCTT GCTCATGCAT CTTGCTTACA

56151 TCACAATCAC AGCTAGGAAA AGCAGCTTAT TTTACCGGCA GTCCCCGTGT

56201 GAAGAATATG TAGAAGCACC AGTAAATAAA AAAGGAAGTT TATCCAGAAT

56251 GCCTAATTCA AAGAAATTCA TGTAACATGA ATACTGAACT TCAGTATTTC

56301 TAATATACGT ATATACACAT TCCTGCTAAC TGTAGAATAT TCTCCTGCAA

56351 GTTTATGGTC CCTGTGCCTC ACCAATGGAA GATCTATCTT GTACTATTCA

56401 ATTCATACTC TCCCTAATAA CAGCACTATA TTAGCAGGTA TCATCATCAA

56451 GTGAAGGCTG CTTGCTAGAT AACTAAAACC AAGATTGGAA AACTAAAAAG

56501 CTGGAGGGAG GGAAAACACA GCCTACAAAA TGCTTACACG ATTAGCAGCA

56551 AATGATGAAG TAGTTACAAG AGGGGCCGAA GAATAGAAAG ATTATCATCG

56601 GATTTGGGAA TTCAAAGGCA GCTCAGCAAA ATACTAGGAC ATGGCTCATA

56651 TAAGATGGAA ATATAAGATG GAATAAGCCT GGAAATACAC CCTCCTCCCC

56701 AATATTTCAG AACATAAAGT CTACAGAAAG AGAGTCCTAA TGTATTGAAC

56751 CTGGTTTCTC AATTGAAACA AAAGTCTTCA AGGAAGGAGA GATACGTAAA

56801 ATTTAACAGG AATACATATG AAGCAGTATC TTTAAAGAAT GTAAATATAT

56851 CAACCAAAAG TAAACTTGAG ATTCAAATTT CCATTGCTAA AGTCTTTTCA

56901 GAGTCAGAAC GACATAATTA TTATATAACT ATTCAAAACA AAACAAAAAA

56951 ACTTACTGGA AAAAAGAACA ACTGGTTTGA GAAGAAAATC TTTTCATGGT

57001 AGAGCAGAAA TAACTGTCAA GGAAAATACT TAGAAAAAGT CATATATAAA

57051 GAGTGGCCTA GTTTTACTGC ACACGTCTTT GCCATGCAGA AACAGCTAAA

57101 TCCCATCTGA CAACTACTTT CCCTTTCGTG TACCTTGTCT TTAGAGAATA

57151 AAATATATCT GGGTTTGATA TAGAGAGAGA CTAATTTTCA CATTAAAAAT

57201 GATTTTCTTA AAAGCCTGGC CTTACAGTTT AAAAATTATA CGATTAACAA

57251 TCAAGATATT ATTCCTATAA AAAGCCAAAC TTTAATCCAT TTAAATCATG

57301 AAACTTAAAA CTTCACTTGA AGCAATTTCA ATCATGAAAC TTAAAACTCC

57351 AAATTACTAT TGTGAATTAA CACTTCTCCA CTATGTATCT TGCAATTTTA

57401 AAAAAACACT TCAGAAAGTA GCATATTTGT AAAACAATAA ATAATTCATA

57451 CCTATATTAT CCTCATTTTG CCATGCAGTT TTACTTAAAT CTCACTTAGA

57501 AATGGAACTC ATTCTTAAAG GGTAGAATGC ACATGATGTA AAGCAGACAC

57551 AGGAAGATTT ATCTTTACTT ACTGAAAGTC AATAGTACAA TTCTAAGATT

57601 TTTTCCATGA AACTACTGAA ATAAGTCCTA CTTGAAAAAA GAAATCCCAC

57651 AAGAGTTAGG AATTAATAAA AACACCAAAA TGAGAAACCC CCCAGCATGG

57701 AAAATTCCTG TCATAAATGT TGATGTTTAT CCAGTTAAAA ATATATACAA

57751 TGAATAATAT CAATAAATAT ATTAGAAGGA AATAATAGAT GTCAGTTACT

57801 GTACCCAAAA CTATACTGTA TTTTAGGCTC TATATTTACT GCAGCACAGA

57851 ACTAAAAGAA TTTTTAAAGC TCTTGCTATT AGAAACTATT ATCCATAGGG

57901 TGCATCTTTA TGCACCAGCT GAGTTGAAAT TCCAAATAAG ATTCCCTTCC

57951 AAATTTAATA AATGGCATTC TTCATTAACA GCATTTAAAA AATAATGGCT

58001 GAAACATATA ATCAACATTA CACTGAAGTT CTATCTGAAG ACAGAAAAAG

58051 TTGCCATCCA CACCAAAGCT ACACATATAC CTTCTGATTT TATAGAATTG

58101 TTCCAATATC TTTTCTGTCA ATATCATTAA AATCAACCTA CCTGTTTGGA

58151 CCGAGGTCTA CCAGGAGAAA ATTTTCTCTT AGTAATAGCT GGTTTACCCA

58201 TGCCAGTTTC TTGGAGTGAC TGAGATGTAA GTTGTTGGCA TGATGTTTCC

58251 AGCAGACGAA CTAAGAGCTG AAGGGTAATT ATGCAGCATG TCATGCGAAG

58301 GCAAGTCTGA AGAAGGTGTT GGGGAGGAAG ACACATCTGC CTTGCTTATG

58351 TCTGCTGATA ATGAAAATGA TGACTCTGTC TCAGATGATA ACTTTATAGA

58401 TTTGCCTCCT TGGTATGAAA CATCTTTCAC ACAACCCTCA ATTGTAGGAG

58451 TCATTTCAGA GTCCATCAAT CCAGTAGAAA GTTCAGAATC TTATTTCTGT

58501 TCCTTTTCTC CTTGTAGCCT TTCTATAACC AACTGTTCCT CAGGACATAA

58551 TGAAGTGCTT TCCTCATGTG GGGACACTAA GGTTTCTAGT GGGAAGAGTG

58601 ACAGATTCAA TGACAAATTT TGGAGGCCTT GATTCTTCTT TTGGATCCAC

58651 TGTTTTAGGT TCCTCTAACA ACTGCAGTTG CTCTGCTGCA CAGTGATCTG

58701 GTGTGTAACG ACTTCAATGT TTTCCGGCAC TCCCATTTTA TCTTCAATTT

58751 GATCTCCCCC ACAAATATGT TTCACTTCAG AAGACATTTT CATTTCTTCA

58801 CTATCAGCCT CATTAGAATT CTGTTTTTCC AATTCGGGTA TTCACTGTAT

58851 GTTGGGATGA TATTGCCAAA ATTCAAGAAC ATTTTGTTAT GGTAATGTAC

58901 AACCAAATTT TTAAATTTTC TAACTATAGA TATATAAAAC ATTTGGCTAC

58951 ACTAGAACTT AAATCAGAAG GTATTCATCA AAGCAGACAA TTATTAAGTG

59001 AATGAAAGCC AAAGTACATA AGGATTTATG GATTAGAATC ANCCNCNCAC

59051 CAGAAAACCT AATGAAAACA TGTTTTACAA CACAAGTACT TCCAAATGGA

59101 TTGAAAATTA CACAGGAAAA GCTCTCATAC TCATTTTTTA GTTAAGAAAA

59151 TGAGGATCAA TCATGTTATG TGAGGTACCT AAGTTAAAAA GTAAAGACTG

59201 ATCTAGAATG TGTAGGCATT TTCTAATAGT AAATACCCAG ATGCGACAAA

59251 GTTACTATAG ACTCAAAAGC ACAGACAGAA AAGATTTGCT AACCACCAAT

59301 ATTTATTTTG CTTAACCATA CCTGCCAACC TAGCCAAAAT ATTCTTTGGA

59351 TATAATCGTT GTTCTTCATC ATTGTCTGTA AATTAAAAGA CTAATCTCAG

59401 GAAATCTATA AACTTAGATA TCAGAAACAT AGTCACCGGT AAATTTTAAA

59451 TCAGGATACC AGTATGTTAA ACCTTTAACT CAATCTCATC AAGGTAATTT

59501 TTAAGTTATA GTAAAAAGAC ACTGCTAGCC TCATTTACCA ATCAGTGACT

59551 AAAATTTATC TATTTATCTA TGTTCTTTTT TTTTTTGAAA CAGGATCTCA

59601 CTCTGTGACC CAAGCTGGAG TGCAGTAGCA GAAACATGGC TCACTGCAGC

59651 CTCAACCTCC TGGGCTCAAG TGGTCCTCCC ACCTCAGCCT CCCAAGCTGC

59701 TGGGACTGCA GGCATGTGTC ACCATGCCCA GGCCTATACA TGTTCTGATA

59751 CCAAACTGAT ACCAAACTGA AATCTCATCT TCTTTCCCAC TTTATTGAAA

59801 GACTCCAGGT AAGGATAAAA GAAAACTCCC GAATACCAGA TCTGATAGTT

59851 AGTCCAAAAT ATTTTTAATC ATGACCTCCC CCCTCCAAAA AAAAAAGCCT

59901 TTCAAGAGGA ACCTAACCTA TCTTTAGATC CATTGTCAAT TCTTTTCCAG

59951 AATCTCTTAA CTAAAAGATT TAGTTACTGT AATGTATATA CATCCACGCA

60001 ATTGCAAAAA TGTCTTTGAG ATAAAGACAT TATCTTATAA CTCAGTCCAA

60051 TTAGACAATA TGAACATACT GCTTACCAGC AATGAGAAGA CTATCTGTGT

60101 CCTCTATACC GTCAGTGTAG GGAAAGGCTT TCTGAATATG ACTCAAAAAT

60151 CCAGAAGCAA AAGAAGATTA ATAATTCTAA CTCCACAAAA AGAAACTTTT

60201 GCATGGCAAA AAAAAATAAT AAAAACAAAG TCAAAAGACA CATAATACAG

60251 CCTGGATAAC ATGGTAAGAC CCTGTCTCTA CAAAAGTAAA AAATTAGCTG

60301 GGCTTCGTGG TACACATAAC TCCTAGCTAA CTCGGGAGGC TGAGGCAGGA

60351 AGATTGCTTG AGCCCAGGTC AAGGCTACAG TGAACTATGA CCATACCAAT

60401 GTATTATGGC TGGGGTGACA GGGTGAGACA CTGTCTCACA CAAATAAGCA

60451 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAC AAGCTAGCAG AAAGTATCTG

60501 CATCATGTAA CACATATAAA GGCTTACATC CCTAACTTAT AAAGAACTCT

60551 TAAGTTAGGG AAAAATGCCA AAATCTTTAA TAACAGGCAA ATCACATGAA

60601 CAGACAATTC ATGAGAAGAA ATAAAAACTG TCCCTTTAAC ACATGAAAAA

60651 ACGATCAACT TCACTCTTAG GATAAACAAA AATTAAAACT TCTTTGATAC

60701 ACTACTTTTT ACCCAGATGA CAGACAAACT TTCAAAAGCT AAACAAGTCA

60751 TCCTGTTTGC AAAGACGTAG GAAAAGTTCT CTCACACATC TCTGGTGGCA

60801 ATGCAAAGTA CCATAAGCCC CAAAAAAGGG AATTTCACAG TATCTAACAA

60851 AGCTACATAT GTGTACACTC CTGAGGCAAT AATCCTAGGA ATTTACCCTA

60901 CAGATTTGTC CCTGAGAATT CAAAAACACA CATGCACAAA GCCAGGGAGT

60951 GTAAAATCAT TTATAATGCA AAAATGTCAT AACCTTACTG AAATACCCAA

61001 TTACAGGCCA CTTGGGTTGA GTAACCGATT AGCACAGATA CACAATGGAG

61051 TGCTATTGCA GCTGTTTAAA AGGAGAATGA GATCTCTTGA ACTTGCCTAA

61101 CTTGCCTGGA AGTGACTTCC AGATTTTATT ACATGAAAAA AGCATCATGC

61151 TAAAGAACAT ATACAACATG CTACCTTCAC TGAAAGAGCA ATATATCCTC

61201 TTATTCTTAG ATGAAAAATA ACAGGAGGTT TAAAACAGAT AACAATGAAG

61251 TTCGTTACTT CCAAGAGGCT GGGGGAAATG CGGTATAAGT ATTGACAAGA

61301 GACAGTGACA ATTCTGAGCA AAATTTCATA TAGTTTTTGA GTTTTGAAAG

61351 TATACTAATA CCTTCTATAT TTAAAAAATT AAATCACTAA GAAAAAGGGG

61401 AATAAAATCT ATTACTGAGA GCAAACTGAA GCAGACTTGC TTTTTAGATT

61451 GAGCAACTGA ATAAATGTGC TGCTCTACAA CCCAGAATTT TTATTGTAGA

61501 AGAACAGACA TGCAAGAATG AAAAGGCAAA GAACTCAGTG GAGAAGGATA

61551 AGAACTGGAG GTGCTGGTAT AAATTCATTA TTTCTAAGTG ATGTATATGT

61601 ATATGAACAT TTATGTGTAT ATACATAACG TGTAGGGGTG TTCAATCTTT

61651 TGGCTTTCCT GGAGCACATT GATAGAAGAA TCGTCTTGGG CCACACACAA

61701 GATACACTAA CACTANTGAC AACTGATGAG CTACACACAC ACACACACAC

61751 ACACACACAC ACACACACAC ACACACCCAA AAAAAAAACC TCATAATGTT

61801 TTAAGAAATT TTATGAATTT CTGTTGGGCC ACATTCAAAG CCATCCTGGA

61851 CCACATGTAG CCTGCGGGCC ATGGGTTGGA CAAACTTCTG TAAGTGTATA

61901 CACATGCATG CATTTCGTGA CACCACCTGC TGAAAGGGTG AAGAAGTAAA

61951 CACCCTCCAG TAGCAATGAG CACACCCGGC ACCCATTCCC CACTAAAGGA

62001 ATCTGGGTTA CTTATTTAAC AATGGACTTA TTTCAGGACT CGGGCATGGG

62051 AGGTATAAGA TGAGCTTGTA ACATCTTGTC ACACCAAAAA GTAATGAAGT

62101 TGTTCAAAAA AGCGGTGAGG GCAGAACACC AGTGCCAGCG TTGAAGGAGC

62151 AACTGACAGC AAGTATGTGA CTATTTGAGC CAAAAAATAA TTAGGTAATG

62201 AGTTGTAAAT GATTGAAGAT AATAGGAGTT CATGAGTCAA TATTAATAGT

62251 AAGCTTAACA TGTGAAAGAA GTGTTCTTGC TTACAAAAGA AAGCAGAGGG

62301 CTAACTGGTA AATGTGGTGG GAGTGCTAGA GCTGGAAATG CATCATTTGC

62351 AACCAAAAGA AAGCATGTTA AAATGGCATC ATCAGGCAGT AAGTTTGTTG

62401 TTGTTTCTGT TGTTGTTGTT GTTGTTGCTG TTTTTTGAGA TAAGAAGTCT

62451 ATCTCTGTCA CCCAGGCTGG AGTGAAGTAG CATGAGTCCA ACTCACTGCA

62501 ACCTCACCTC CTGGGTTCAA GCGATTCTCC GGTCTCAGCA TCTGAGTAGC

62551 TGGGATTACA TGGCACCCGC TACCATGCCT GACCTAATTT TTGTATTTTT

62601 TAGTACAGAC AGGGGTTCAC CATGTTGGCT AGGCTGATCT TGAACTCCTG

62651 ACCTCAGGTG ATCCACCCAC TTTAGCCTTC CAAAGTGCTG GGATTACAGG

62701 TGTGAGCCAC CACACCCGCC TAGGGAGTAA GTTTTTCAAA ATCTTTAAGG

62751 AAATTCTGAG GAAAGCAAGA TATTTGCATG GTCTTAAAGT ATCCTCACAT

62801 ACTGCTTTAT TAGATACAAA GGAGGGGGGA ATAGAAATTG GGCAACAGCC

62851 TGACCAGGTG ATTCTCATGA GGGAAAGTGG AATAATATGT GCTTCCAGTT

62901 GTGATACCCT GAGGATGGAT CAGCATTTTA CAGTATTCTG GCCAATAATG

62951 CATGCCTCTC ATCTAATTAT AAGGGGTTAT CAAAAACAAA ATGGGGAAAT

63001 TTCTGTTTGA ACAAAGAAAA AAAACAAATA TATCGAGAAC TCTATTCTTC

63051 ATAAATACCA ATGACAAAAA CTAAATCCTA GAACCTACTT GGAGGAAGGG

63101 GTAGATTATG AGGGACATAA GATCAAATGA CATAACTGTA ATATGGCTGG

63151 TACATTAGAT AAACATACGG CATTGATGTA AGTTTAGGAA TTTGATAGCA

63201 GGATTGTGAT TTTTAAAGAA TATTCCTACT ATTAAGAAAT ACATACTGAA

63251 ATGGTGGTAA AAAGGCACAA TGTATGTAAT TAACCCTCAA ATAGTAGGGG

63301 GGTTGGGGGA ATAGAGACAC ACAGACACAC ACACATACAC ACACACACAC

63351 ACAGAGAAAG TGAGAGAGGG CATGCCCAAT GATAATGAAA TGCTAACAAC

63401 AGATATATCT AAGTAAATGG GATATGGGTA TTATTTTTAT TTTTTCCAAC

63451 TTTTAGAGTT TGAACTTATT TTCAAGTAAA AGCTTTCTAA AAACGCATAA

63501 CATACCAAAG AACAGACATT CTTGAGATAA AAGTAGGAAA AAGAAACCTA

63551 TCTGACAATG ACTGGTTTAC AATAAAGATC CTTAAAAGAT TAACCCCACT

63601 CCAGCTCACC AGGGAGCAGC CCCAAACTAG ACTGACAGCC CCGTGGGGGC

63651 ACACTGATTT GCCCCAACAT CTCCAGCCTT CACTACAGTG GTGTTCGCAC

63701 ACAGTAAACA CTCAAATGTT AAATGCAAAC AAATGAGCAA ATTATGACTC

63751 AAGACTACAG AGAGAACTAC AGAAGAATTA AACAGCAGAG AAAGATGATC

63801 ATTCTTCAAA TGGTTCAAAG GACAAACCTT TCAATCTATG AAAAACTCTA

63851 TGGTACCTGT TTCTGTACTT ACTTTGTGTT AGGCATTGTG CTGGGCACCT

63901 TTATAGATAC CACTTCATTA AATCCCAACA TCCCTGTGAG GTAAGTACCG

63951 TTAACCTTCT ATACACTGAC TTTAGGGAAG TTAAACAGGT AGCCAAAGAT

64001 CATCAATTTA GTAACTGAAA AAACTGCAGT TTGACTCCAC AGCATAAGCT

64051 TTTAACCACC ACACTATAGT GCCTTCATAG AACAGAATAA AAAAATTAAG

64101 TATCCAATAG TATTCCCAGA AATTATGTAA TCCTGTCACT CTCAAAAGAG

64151 AATAGCAGAT TACAAAGAGC AAATCAAAAA GAAGCACACC AAAGAGGAGA

64201 CAGAACAAGC TGAGAAAGAC ACCCAGAATT CTCTACCAGT TCTCAAGACA

64251 ATGAAAACCA TAATAAAGAA GATTAAGAGC AAGAGACAAA AATTATCCAG

64301 TAGTTACTAG ATATTATTAG AGAGTGTAAA GAAGGTAATT TTTTAAGTAA

64351 ATATATTTTT TAAAAAAGGT GCTGGGGTGG GGGGTGAAGG CGGGGATGGG

64401 GATTCACACA TCTCCCAAAG CTTTCAGGAA GAAAAAAAGG ATTATGATTA

64451 AATTTTTTCA AGTTAAGATT TTTCTCGGTG ACAGCATAAA CTGAAAAAAC

64501 TGAAGAAAAT GTTTTCAGAG TATAAAAAAG AAAAATTTGT AATATGAAAC

64551 ATTATACTGT GCCAAGTTCT TATAGCCTAA AAGGAACAGT CTCTTTCCGA

64601 CATGTAGGGT TTCAAAAACT TTATAATTAT TTTTAAAGGA TCACAACCAA

64651 GACTCCGAAA GATTGAGGGT AAAGTTGGAA TTAACAGAGG AAATATATTT

64701 TTGCAAGAAA ATTGTGACAA GGTTTACAAT CTAGGTTAAT CAAATCAAAC

64751 AGAGAAAAGG GGAATAAAAA CTTTATTTTC AGTGGGGAAT GGGAGAAAAT

64801 TTATATCTTT AATATTTATA ATCATTTACA TTCACAAAAT GAAGATTCTG

64851 AATTATAAAT CATTGCAGGA AGTAAAAGAA GAGAAAAATA GAAAGAAAAG

64901 AAAGTTTTGC CTCAAAACAG CCAAGCATTT CAATTACAAA CCGTCAATCC

64951 AAACAGTTAC CTCTATTAAG CTTTTCAAAA GATACATTTT TATAACACAA

65001 AAGAATCCAA AATAAATGTG AAAAGATAAC CATTCAACTG TTAAACTAAC

65051 ACCCTACGTG GCCATAGTGT CAGGCAAAGC AAAATACCTG CCCTTCCTGA

65101 TCCCTCAACA AAAAACACAT TACATAGAAT AAAGAACAAT TTTATACTGG

65151 TAAAAAACAC AATATATTAA CACTGGCCTG ACCTACTTGC TAAATAACAG

65201 CCACAAATTA TTTGTTTAAA AATATGATAA ATTGATAGGA ACAATTAATA

65251 GTGGTCAATT GTAACTTGTT GAATCAACAA GTCAAAAAAT AAGGTAAAAG

65301 GACTTCATCT AACTAAATGA AATTAATAAA CACAAATGCT ACACCTTTAA

65351 AAAGTCAATA CTTCAAGTAT CAAAATATTT ATTTTAAAAA ACCTACCTTA

65401 GTTAAATTCT CTGATTAAAT GAAATGTAAG CATAAATTAA CATACTTCAG

65451 CACAACTTAA AAAAAAGTTA TTCGCTNAGG GATATACATA CATTAAAGGT

65501 TACAAATACA ATAAACTTGG CTTCAGTCAA AGCTATAGCC TAAGGTAAAC

65551 TTATAGGCTT AAATGTCCTT TTTCCTTAGG AAAGAAAATG AATTACAAAT

65601 TCAACTTCAT ATTAAAAGTA AAAAGGCAAG TAGAGGAACT GAGTGAAGAT

65651 AAGAGTGTTA ATATCCAATC AGTCAAACAG CAGAGTTTTC CTTTCCAATG

65701 ATGTCATTCA GCAAGAGAAG GAATCTGAAC AACCTGAGGA AGCAGGCCAG

65751 AGTTCATCAC AATCCTTCAG CCCTCAGGTC CCACTTCCCA GGTAGCCACA

65801 GCTGAGCACA GTTACCCAGC AGCTCTTTTT CCCCCCAGGA GAGAAAGCCC

65851 CTCCCCTCAA CCCCCACCAC TCAGGCAGAT GCCTAGTAGA ACTTGCTGAA

65901 GACCACAACA GAACCTGGTA ATACTGCTTG CAGTTCTAGG TGCCAAACCT

65951 CACTGGCGAG GACAGGGTGC AGGTACAGAA TCTCTCTGCG TCTGCTCCCA

66001 CATCCTCCCC ACGCCAGGGA CCTGGGGTTC TGGCGACATC ACCCTCCTTT

66051 TCCAGGCCCT CCACCTTCAC CCTAGAAAAA GCAGTTCCGA GAAGGGCAAT

66101 GACAATGCTG TGCCTTCCAC TCCCGCACAC GGGCCATCAC GCCCTTTTCA

66151 GCTCCAGGGA AAACCCGCTT CAGGCCCCAT GCAGCACCTG AGGGTCATCT

66201 TCATCCCTCA ACCTCGCGAC ACCAGCAGCC CAGGAAGACT AAGCTTAAAA

66251 GCTAAACCGC ACCTTGGATT CCAAGGGCTA TGTCCACTAC CCCACTGCCC

66301 CCAACCCGGC TCTGAACGCC TCACCCTGAA GGGGCAGAAG CCAAGTGAGG

66351 TAGGAAGTTA GTTAATGAGT TCATCGGCAT TTTTTATAAT AGCTCAAAAT

66401 TTTGAAGGAC CCAAATGTTC ACCAACAGGT GATTCAATAC ACAAATTGTG

66451 GTATCTCCAG CACTCGGTAA TACAAAAGAA TCACTACTGA TCTGTGCAGC

66501 AATAGGGATG CATTTCAAAA TAATTACACT GAGTTAAAGA AGCCAGACCA

66551 AAAACGAGTA TATACTATAT GAAGCTTTTA TTAAAAATTC TAGGAAGTGA

66601 ATACTAATCT ATAGTGAAAA AGCAGACTAG GAAGACAGAG GGTTTGGGTT

66651 TGAACAGCCA CAAAGCAAGC CAAGAGGCAC CAGGAAACTT TGACGGTGAT

66701 GACTATGTTC ATTATCTTGA AGAGTGTACA GTTTACTGTA TGTCAGTTAT

66751 ATGTCAATAA AGCTGTTTTT AAAAAGCTGA TGGTAATGTA TAGATTTGAA

66801 TAGATATCCG ATTTGTCTGT TCTCCATATA AAACATACAG AGGATTTAAA

66851 AAAGTAAACA ACTTACTTTG CATTTCCAGC CATTGGTTGG TACAGATTTC

66901 GTAATTCGTT GAAGACAAAA AGTATGATAC CCTTTGTCAC ACGTATCACA

66951 CACTAGCATC TTGCTATCTT CTCCCGATTG TCTAAAAAGT AAGATAGCAT

67001 TAATGATGGC TTATCTTTAA ACTTATGTTT TGCAACATAA GTAATCATGA

67051 AAATCATCAG TCCTGGGAAC CGCACAGTTC ATAAATACCT CAGTATCTGT

67101 TTTGTCTCTG CAGATAGTAC CAGAGGTACC CTCCATAAGG ATTACCTCCT

67151 AAATGGTGAT CTTTACCCCA ATGCTCACCT ATGGTTAACT TGCTCTAGCC

67201 ATTTTAGGTT TCCTGCAAAT GAGGAAGGGT TAAGGCAAGA TGAATAGCCT

67251 CTGATCTTTA CTTTTAAAAT ATAATTTTTG AGAGGAAGGC GCTGTAACTG

67301 CTATGTGCTA CTGTGTGGAA AGATCAAATC TTGGCACAGC AAATTGAAAA

67351 GACTTGTCAT ATAACGTAAA GAGGATCAAA TTTGACATCA GATCTCTATT

67401 TGTATCCAGG CTGCTGTTTT CTAGCTGTGT CACTAACAAC TTAGACTAAA

67451 GCTCTCTGAG TTTCAGGTAT AAAACGGGAA TAATAAACAT TACTGTGAGA

67501 ATTAAATGTA ATGCAGGTTC AAGTGCTTAG AATGTCTATT AAGCAATTAA

67551 ATGCTGAATA ATTATTTCAA AAGATGAACC TTGTCATAAT TATTAAGAAT

67601 TATAATTGAA AACCTAAAAC CTTTCTTTAA ACACTCTTCT GCCCCCAAAG

67651 ATTGGGCCCC TGTCCTACAG CATTATCTCT GTTGAGATTT TTGACTATAA

67701 TTACTTTCAG ATACTATGAT TTTAAATTCA AGAGGAGGGG AAGAGAAAAT

67751 ACAGGGAAAG CAAGAAGAGC TGAGAGAGGA ATCTCTGAAT GAAATCTGGG

67801 GGATAAACAG AAGTCAACAG GAAGATGGGT CAGTTGGCCT CCAATTATTA

67851 TTCAGTTCAA CCTCTCCATA AAAAGTCACA TGTTTTATCT CTTCAGCTAC

67901 ATGCAAAGAT CTTGGAGAAC AAGTACTCTT CCTTCAAGTT CTTTTAATCC

67951 TTCCCAAGAA ACTGAGTGCA GATACAAGGT ATCGAATAAA TGTTTACTGA

68001 ATATTTTATC TAATTTTTAC CAAAATATGA AGGTACATAG TCCTATTTAT

68051 GTCACGTAAC TCTAAGATAT TGACGCTTAT TTCTTATAAA ACTAAATAAT

68101 AAAAACAGAC TGATCATGGC AGTTGGGCAT AATTCTTGCT GGTAACAACA

68151 AAAATTCTCA GCCTGTAAGT GAAGATGCTG GTAACATCCC CAAATTATCA

68201 TGCTCATTAG AATCATGGGG GTGCAAGCGG AAATCACAGA AAAGACTGGA

68251 GAAATGACCA AGAGATGAAA TACAATAGGA AAAGATAACC CCCTTACAAA

68301 TTTGTAAATG CCACATATTT CATTTTGGAA TTATGCTGAC CAGGATCTAC

68351 TCAAGGTGGC TTTTAGAGAG ATGCAGATGT ACATTAAAAT AATAGTAGAA

68401 AGTGTCCTTC CTGGAATGGA AATTCAAACA CATGACTGAC GTTTTGACTC

68451 AACTCTAATT CTTCTACGTC TGTAGTGAGA GGTTTAAATC CTATCACATC

68501 CCCTCCCCAG TGCCCCTGAA GACAAGTTAC TTTATTCTTC TCATGCTTGT

68551 TTTAAATTGT TAATATCGCT TATTTTTTAA ACTGTTGGTA AATTTAAATT

68601 AGCTCTTTAG ACGACCAGAA CAATTTAAAT GATTAAAATC AGTTTTGTTT

68651 AGACTTCTTT CAAAATAATA TAAACGTTAA TATCCAGTAA TTTTTTTAAG

68701 TATGATGAAG TCACTCTGAA TGAATACAGC CAAAATATGA ACAACCTCTA

68751 TTATATTACA CAAACTTTTA GCGCCTAGCA ATAGGGTGCC TCTTAAACCC

68801 AATACACAGC TTTGAATTGA AATGAAAACT TACTTGCAGT TCTGGCACAC

68851 TTTGCACTCA GGACATTGCC AACCTGCACG TTTTAAAGGA GTAACCGCTA

68901 TATCCAGGCA CATTCCATGA TAGTGCTGAC CACAAGTAGT ACAAAAGAAC

68951 TGATCTAAGA GGTCTCCCGG GCTGTCGCAC ACTGCACAGT TTGCATCTTC

69001 CTTCGCTATA ATTAACAGTA AAACAATGAA ATTGTTGTAT AAGAATTTAA

69051 ATTTTTTCTG ACTACACAGT AAAATCATTT GAAAGGATTT GCATCATGAA

69101 CCTTTCAGAC ATTTGAAGTT ATTCACATTG AATTGTCATC TAATCAAAAA

69151 GAGGTATCAA TAAAAACACT GTAGGGTATT TAATCTAAAT GTAACCACAT

69201 TAAATTTAAT CGTATAGTTT TGCAATTATT TGGTGGCTAT ATCTACTTAA

69251 GCCATAAGCA GGTCTTTCTT TAATTTTCTA TTCCTAATGC CAATGATAAT

69301 GCTGGATACC TAATTAATGC TCAATATATG CTCACTGCAA AGAACCAAAC

69351 AAGGAAAATA CCAACTAAGA AATGCTTTGC AGTGTAACAT AAACATTTTC

69401 TTTGAATGCT AAATATATTT TGAAATTACA AAATCAGACA AGAGACAAAA

69451 TTAAGAAACG TTAATATCAA TTAGACTAAG ATGCTTCTTA AGCATAAACA

69501 GACTATTCAA ATCACATAAG GGCTTTTTTT TGATTACTGG AAAATGTCTT

69551 ATGTGGAAGA ACATTAAAGA CAGAAGCTAC ATATTCATAC ACAAACACAT

69601 TACTTAATAT ACTAATTCTA TATTCATCTA TATTAATTTC TAGTTGTAAA

69651 AGCATTAAAA TCCACATAAT TATGGACATC ATCCATCCCT AAATGTGGAT

69701 TAAAAGAAAA TGTACTAACA GTTCTTTTAC CATATAAAAC AGAAAATATA

69751 AGGATAAACT GCCCTGCCAA ATATACAGTT AAACTTATGC ATATTGCAAA

69801 ATAAGGAAAA TAATGTATTC TAAAATCATA CCAATCTTAG ATAATGTATA

69851 AAAAATATGC CTGTATATAA CAAGTATCAC AAAGTATATG AATCTTTTCA

69901 TTTTTTGAAG GTTTGATCAT TCCTATCTAC TATTCTGACT CATATGTTCT

69951 TTCTTTTCCA GTCAAGCTTA TCATACCAAC ATTTGATAAT AATATATAAA

70001 TATGCCTGTA TTTAACAAGT ATAACAAAGT ATATGAACCA TTATTTTTCC

70051 CTTTTTTTTT AGACAGTTTC ACTCTGTCAC CAAGGCTAGA GAGCAATGGC

70101 GCGATCTAGG CTTACTGTAA CCTCCGCCTC CCAGGTTCAA GGGATTCTCA

70151 CGCCTCAGCC TCCTCAGTAG CTGGGATTAC TGGAGTGTGC CACCATGCCC

70201 ACCTAATTTT TATATTTTTA GTAGAGACGA TGTTTCACCA CATAGCCCAG

70251 GCTGGTCTCA AACTCGTGAG CTCAAGCAAT CCTCCTGCCT CACCCTCCAA

70301 AAGTGCTGGG ATTACAGGTG TCACCTACCG CACTCAGCCT TTTTCCCATT

70351 TTTTGAAGGT TTGGTCAGTC CTATCAATTT CTCTCTGACT CATACGTTCT

70401 TTCTTTTCCA GTCAAGCATC TTGAAACAGA GTAAAAATAT ATTTCTTTTA

70451 TTTGTACCGG AGTCTGCAAA CTTTTCCTGA AAAGGGCCAG ATAGTAAATA

70501 TTTTAGGCTT TGTGAGCCAT AGCAGTCTCT GACAAAAAGT CAGACCTTTT

70551 GTTTTAATTT ACACTCTTTT AAAAATGTAA AAATAATTCC TCGCTTGAGG

70601 GCAGTACAAA AACAGGCTTC AAAATGTGGA CGCTGGCTGG ACCTCTGACA

70651 TACTTCAGGA AGGCTGGCTT AGCACCTAAT ACTCATCTGA AGCTGCATTA

70701 GTGAGGCTGC CAATGCCCAT AGGAAACCCG ATTTAGTCTT TGGCTTTTTT

70751 GCACTTTGTA GCATTTGCAT TGCTAGCCAC TCCCACATTA AAACGCCCCT

70801 TTCCTTAGTT TCTATCACGG CAACTCTCTC CTAATTTCTC CTTAGTTTTC

70851 CCCCACTTTC ATCTCATCCT CCTTTGTTGG CTTTTGTACC TATACAATCT

70901 TTCTAAATGC TGGAGTTTCT TAGGATTTCA TCCTTTTCCT TCTTTCCTAA

70951 TCCCCCATAG TTTCCCTTTG TGATCACATC AACTCTCACG CCATAAAATG

71001 CCACCATGAT TCCCAAATCT GTATTATTGG CCCTAGAATT CTTTCATAAA

71051 CCCCAAACCT TTATTCTTCA AGTCTTACTG GATCTCAATA GCCAAGTGTT

71101 CTAAACACTC AATCTCAACT GCTCTAAAGT GAAACTTTTT TAAAAACCCG

71151 AAACAGCATC CATTTTTCTC AAGAATAGAT AAAGGCAGAA ACCTTAGTAT

71201 CATTGTTGAC TCTGAACTCA GCTTTGACCC AACACATCCA GCCAGATCCC

71251 AATTCTTATG TATTAAACTT CCTACACATC ATTCTTTCTT TATATGTTTA

71301 TAGTTTAGTC TATCATACTA GGTTGGTGCA AAAGTAACTG CAGTTTTTGA

71351 CATTACTTTT AATGGCAAAG ACTGCAATTA CCTTTGCACC TACCTAATAC

71401 TCTGTCTCGC TAACTGCAGT ATCTTCTGCA TCAAATCATC TCTACTTACG

71451 GTTCTGACAT CCTCTCTAAA TCATTTTCTA CACATCCAGA ACAATCTTTC

71501 AAAAATGTAA ATCTAATTGT TAACCTCTGT ATAAATTAAA ACTCCACCAA

71551 TACCTCATTT TTCACCTAAA AGAAAATCAG AATTTTCAAG TATGATGCAA

71601 AAAGGTCCTT ATCTCCCTTT CCAACTGAAT CTCAGAACCA CTCACTATTT

71651 CGTGGTCATG GTGGGTTGTC TTCCATGCAC CTCACATAAC ATGCTATTCA

71701 TGTCTGTGTG CTTTTACACA TTCTGTTCCC TCTGCTTGAA ATTTTGTTTT

71751 TCTGCTGTGC TCCCAGCCTT CAAAACTCTG CTCATGGCTG GGCACAGAGG

71801 CTCATGCCTG TAATCCCAGC ACTCTGGGAG GCCAAAGCAG ATGGATCACC

71851 TGAGGTCAGG AGTTCGAGAC CAGCCGGGCC AACATGGTGA AACCCCATCT

71901 CTACTAAAAA TACAAATTAG CAGGGTGTGG TGGCACATGC CTGTAGTCCC

71951 AGCTACTCAG GAGGCTGAGG CAGGAGAATC GCTTGAACCA AGGAGGTGGA

72001 GGCTGCAGTG ACTAGAGTTT ATGCCACGGC ACTCCAGCCT GGGGGACAGA

72051 GTGAGCACCT GTCTCAAAAA AAAAATCTGC ACATTATTTC CTGAATACCT

72101 ATTACCACAC CCAAATACCC ATTTAGTTGT CGAATATTAC TTTTACCCAT

72151 ATGCTTACAA GAAACTTCTG TTACATAATC ATTTATTTAC AGCACAACTC

72201 TGTGAATCCT TGAAGGACAG GAGCCTTAAC TTTTTTAACT TTGTATCCCC

72251 AACTGCCTAA CATGAATCAA GTCTTATTGA ACATATTTTA AGTGAAGGAC

72301 TTACTGCTAA AATAACTTTT AAATGGCTCT TTAAGTGATA GGCATTTAAA

72351 ATAAATCATT AATCTAACAA TGGAAGCATC ATAAATTGGT TCATTTTTGA

72401 TAGAAAGGAC ATAACTGGGA TGTTATGTTT CTTAATATTA AGAGAGTACT

72451 AGTATTTATC TTTCAAAATA TGTACATTGA AAAATTGATC TCTTTTTGCT

72501 CACTGTAAAA CTTTTAAAAA TTGGGGGAAT ACTCAACTAA TTATCAGAAA

72551 CTAATTATCA GATAATCAAT TCATTTTTCT ATTATACTCT CCTAGGAACA

72601 CTAAAATGCT TCTGTGAAAC TTTCTAGAGT TTGCTCCCCT GACCACTTCA

72651 AGTTGCCATG GTAGCTACTA GCGACATGTG GTTTCTGAAC AAGTGAAATG

72701 TAATTAGTTC AAATCGAGGT ATGCAGTAAG CATAAAATGC ACACTGGATT

72751 CCAAAATCTT AATGGGGAAA AAGATCTCAA AATTTGAAAT ATTACTATTT

72801 TGGATTACTG AATTAAATAA AATTTACTAC AATTGTTCCC AAATGTTTCC

72851 TTTTCCTCAA ATTTTTAACA TACCCACTAG AAAAATTACT TATGTTGCTC

72901 ACATTATATT TATACTGCAC AGCACTGTTA TATGCAACAA AGTTCACTCT

72951 GCAACAAGAC AACTGTCATT GTCACAAAAA TCACTTTTTA GACTATGATG

73001 ATCTCCACCA ATGCCTTACT GACAACCTTG CTGTGTTATC TGATTACTAT

73051 GGATCATTGG TAATAAATTA GTCAAAGAAA AACATCCATG TAATACATCT

73101 GGTGCAAAAA CACTTAATAT GCCTTATGTG AAAAACAATA TTATTTTTAA

73151 AAGCACTACC ACAAAGAAAT GAGGTTGGTT CCAACCCTCC CAGTCAGGGA

73201 GAAGATGTGT GGGAATACTG AAACAACCTT ATGGAGGTCA TGTATAAGAA

73251 GATTATCGAT ACTACTGGAT AGGTTTGGTG TCATCACAGA AATTAAATAT

73301 GAATATTTAG ACACACATGT CTGTAAGCCA GAGACATTAA GTTTAAAGCA

73351 ATAATCAACT AAGAAATTTT TCTTTAAACA GTTGAAAAAG CAAAAAGACA

73401 GGCTATAACT AAAGATAATT TAAGAGGGGA GAGGAGTAAA ATCCAGGTCT

73451 ATTTGGCTTC TAAGATCAGG CTCTTGACTA CTAATCAAAT TGACTCCTCA

73501 GCAAACTATA CTACTGATCA ATGAAAGTGA TGAATATTTG AGTATACACA

73551 AAAGTAGACA TGAAATTCCA ACAGTGGCAT ACAGTGAAGC TAAATGAAGT

73601 AAAGGGAGCA AGGTTCTTAG GCAGGAGAAA AGTGAGAGGA AACAAAATGA

73651 TCATCTTTAA AGAAGGTCAT TTCCTAAGAG ACAGCTGTAA AAAAAGAAGA

73701 GATAAATAAA AAAGACAAAA ACATTGAGCT TAAATTAGAA CAGAGCTTAT

73751 CACAGATCCT TAAACTTGAT GAAACTGTTG CTTAAGAAAG TCCAGACAAC

73801 ACATAAGAAT AAAAGCATTG GTGAACAGCA AGAAAAGTCA AAATAGCTGT

73851 CATACAGTGT AAATTGAAGA AGGACCAAAT CAGCATTGCT TTCTAATTTC

73901 CATCAAACCC TATCATCTGC CAATTTTCAT TACTGGCAGG ACACTGGGCT

73951 GAGTGATTTG TCTATAAAAG AGAATCTCTG GAAAGAAAAA ATAAATCATG

74001 GATGTCATCC AAAGAGGCTA GACCGTATCA TTGGCAGGTA GATAAGAAAG

74051 GTCAGAGGAC TGACAGAATT TAGGGCAAAA GAAAAGCAGC AGGACTTAAT

74101 GTCAAGAAAT ACAAAGATAA CCAGAGAAAA GAGGCTGGAG TTAAAGCTTA

74151 AGTGAAGTAA AAGGAATTAA AGCTAAATGA TGAGTAAATA CATTGAGGAA

74201 CAGGGGGTGA ATTAAGATAT GTAGCATTTC CATGTTTAAA CCTTGCAAAA

74251 ACTTCTCATT GCAGACCGAA CAGGACCCAA ACTCCTTCCC TTGCTTATAA

74301 GCCTACATGA TCTAGCCTTT GTTCGCCTTG ATGATGTCTC TACTACCCTC

74351 ACCTAGTAGG CTACTATGCT CCAAGTAAAT GATGTCTCTA CTACCCTCAC

74401 ATAGTAGGCT ACTATGCTCC AAGTAAACGA CATGCTGTCT GTTCATGAAT

74451 CATGCCAAGT CCACTCCTCA AGGTCTGCGT AGCGGTCTGT TCCCTCTCCC

74501 TGGAATGTTC TTTCCTCTTA TCTCGCATGA TTGGCTTCTT ACCATTCAGT

74551 TTTCCTATTC AGGAAGTATA TCTGGTTGTA TCTCCTAGAT GGATTTTTAG

74601 TGTAAAATTT CCAGACAAGG TTAATGTATC CTTGTATCAT CATGAAAATA

74651 ATGTTGCAAC AANGACCAGC CATTTAACTA TGACAGAGCA CCCTAAAAGT

74701 GTTTCCTGAT GAAAATCTTG GCCTTCTTCA CAGATACTCT CTTTAGTGGA

74751 TTTCTTTATA ATGAGATACA TGCTTTTGTT AAATTTCTCA ACTTTTATAA

74801 AAAGAGGTCA ACCTTACTCC TAACTCAGTC AACTATCACA GCTACTGCTC

74851 TGCCCTTTAG GAAGCATCAG AAAATACATA TACTCAATAT GTATTATCAT

74901 TCTCATAACT TAAGCCTTAG ATATGAGGTA AAATAACTAC CCTTTTTAAA

74951 GCAATTAATA TATACAAGGC ACAATGTTAT GTGAATTCCA TTCATTGTGT

75001 TCATTTAACC CTCATAATAA CACTATGAGT TTAAGACAGT ATCATTTTAA

75051 AAGCATAAAA AGTAACTTCT GCCATGACAC ACAATTAGGA TAGGAAGAAA

75101 TATTTATAAA AGATGTTAAA AAGGTGACAA AACATCCTAT CTGCAATATT

75151 CTTTAAATTA TATCCTTGGA ACTTAATCCA AGATTATGAT CTTCTTAACA

75201 GATGGGTCAG AACGCTGTGT GGTTAGAATG CACTGTTTAA GATCCCCAAG

75251 GAGGCCAGGC ACGATGGCTC ACACCTCTGT ATCCCAGCAG TTTGGGAGGC

75301 TGAGACGGGC AGACCACGAG GTCAGGAGTC CGAGACAAAT CTAGCCAACA

75351 TAGTGAAACC CCGTCTCTAC TAAAAATACA AAAAATTAGC CGGGTGTTAT

75401 GATGTGCACC TGTAATCCCA CCTACTTGGG AGGCTGAGGC AGGAGAAATC

75451 ACCTGAACCC AGAAAGCGGA GTTTTCAGTG AGCCAAGGCC ATGCCACTGC

75501 ATTCCAGCCA GGGTGACAGA GCGAGACTCC ATCTCAAAAA AAAAAAAAAA

75551 AAAAAAAAAC CAAAGCAAAT ATAATTTAGT CATTTAGGCC TTAATTTTAT

75601 ACCACTGACT TATTTTGAAG GCTGCTATAA GAAACAGCCC TATGAAACTG

75651 GTATTTTCCT ACTGCAAGGT GGCTACTTTA AGACAATTTT TCATTGCATT

75701 CTATCAAGGG ATGTCTTATT ATTATATCAT TATATCAAGT GATGTTATAA

75751 ATAGTAAGAA TCAGATTAAG GGCTCATATG TCCTTCTTTG TATTGACTGT

75801 TGAAAAGGTA TGGGGCCAAA TTTGTAGTTT GTCTGGAATT ACATATTTTT

75851 GGGGGTCTCT ATTATCTTCA TACTTATCCT ATCTAAATTT TCCATTGCCA

75901 AATTTCCTTA CTTATTTTTA GTTTTATCCT ATTGCTCATG TATTTTTATG

75951 TCTCCATAAG TCTATTTTGG AAAAAGGCAG AGTACTCATA ATTTTAGTAT

76001 ATCTTTTAGC TTTATGTTGC CATAAACCTT TCATTATATA CATGATCAAC

76051 AACAGCAAAT TATCTCACTT CAGTATTTAG TTTATTATTT TACAAACTGA

76101 TTTATGATTG CTAACATGTA ACTGAAGGTA TACACTATTA GAACACAGTT

76151 TTCAGTAGAA AGTAGCACTG CCATTGAGTA AAAAAATGTT CTAACATTAG

76201 AGCAACATTC TTATACAAGT TTGCATGTTG TTTACTGAGG TCTAAAGCAT

76251 GACTACACAA AAGGCTGAAT AAAATTCAGA TTCTTACATA CACATAAAAT

76301 TGTTTTATTG AGATGACAAA GTATATTTAT TATGCCACCC AGAATATAAT

76351 CCACTCTGAT AACTGCCAGT GTATGCACTT GCTGAAGTAA CTCAGTACAT

76401 AAATGGTAGC CACAACAGTT GCTGTGCATG AAAGTTCTTC TCTTCCAGAT

76451 TGAAGAGTGT ACAATCTAAA GCATTTTAAA ACTTTAAATC CCTTATTAGC

76501 TTAAATATAA TTTAAAATTT TAGTTTGCCG TACCTATAAT TTGTCTGTAC

76551 ACTAGGTTAC TAAGGGTGAT ATGATTACAT ATGTGGATAC AAAATAATTT

76601 TAATGGAAAA TGAAATTAGG GTACTCAACA AAGATAAAGG GTAATGATCA

76651 TGTACACTAA CCGTATTTGA GATTAGTTTA AGCCTGGGGT AGCTATACTT

76701 ATGTTTCACA GACCTTGAGA AGATAGGGAA AAAAAGCTTT TATCAACATT

76751 GCTAAGGAAC AGGTAAAAGC TAACATTAGG TAACTAAGAG GTGACATAAA

76801 AAAGACTGAA TAAAATATCA TGGAGGTTTC ATAATAAGAT TGGAAATTCC

76851 ATAGACTAGG AGAGAAAAGA TCCCAAAATA TACATGCTCA TTGGGAAAAC

76901 AGCTAGTAAG AACAAGGAGA GATCTCTATT TAATGATACA ATAGTAGAGT

76951 TATAATTTCC TGTATATTGT AAATTTCAAG CATTTAAACA TTTTCATTGA

77001 ATTATAAAAT ATTATTTGTA AAAGAAAGAA AAACAGCACA ACTGCAGATT

77051 ACAGATGACT AAGATAGATG AATCATGAAA AGGTGCTAGC AGAGATTTCT

77101 ATCACACCTA TCAGGGATAC ACAATTTCCA AGAATTTCAG AAGTGTTTGG

77151 TGTTCCTATT AACATAAATC CGGAAATAAC ACCTGAGTGA ACTGTCTTCT

77201 AATTCTTCAA CTGGATGGCT TTTTAGTGTA AAAGATGTTG AATACTGATT

77251 GACTTTTTAA TAATTTTATA GTATATGTCA GAAATATTGC ACAGTCCCTA

77301 TTTACATCAT TCTACAGTGG TTTTTAAAAT GTTTTAAGAA TAAAAAACAT

77351 GAAAACTTTA TTTGATTTTT CTGAGGAAAT AACTTTTTGG ATTTAATTTC

77401 AATGAAACCG TTGATAACAT TTCCCTCCCC AACAATCTCT GGCAACGATC

77451 CCTCAGATTT TAATGATTAT GTATTATTAC CTTTTAATAC AAGTAGAATA

77501 ACACTCAGGG AATTTACAAC ATTTGTTATT TTCAGTAAAT ACATTGGTTG

77551 AAGTTTAAAA GTCTATCCGT AGTAAACTTA CATCTTTCAG GAGCTTGGTC

77601 AATGTGTTCT GGACAAAGCA GGAAGATGTG ACTGAAATCC TGAAAGGAGC

77651 CGGCTCCTGC AGCACAAGGA TAATGATACA TCTGGGTACA TTTCTCRRCA

77701 CAGCATTTGA TAGTGGCTCC AAAGTGCTTA CAAAATGCAC ATTGCTGAAA

77751 GGGGTAAAGG AGAGAAATCT CTTTATAAAA CCTTGAAAAG GAATATTTAA

77801 ATATAAGCTG GGAAGGTATA AAAAACTCTC TGTAACATCA CAAGTAAACA

77851 AATTGAACCT GCAAAATATT AAACAAAGGA TTCATTAAAA ATAATAAAAT

77901 CTACATTACT CAATTTAGTG CTTTGTGTGC TACCAACTCA TCCTTCCATT

77951 CAAATTAGAA AGTTAGAATT TCATTCCTTA TATTTTCAAA AATAAATTGT

78001 GAAGCATTTT AGAAACAAAA CCTAAAATTT TTTTTTAAAA GCAAATAGTA

78051 ATATGGTTAA AGGGGCAGGT TTCTATATTG AGGATTATTA TAAAGTTTTT

78101 AAATCCTACC AAAACTAGTA ATAGGAACAT ATATTATTTA TGAGACATAT

78151 TACTATTTTT TACCCTGCCT AAAAATAAAT ACAAATAAAT TCATCAATTA

78201 TAAGTTAACA GGGACACAAA TGGTTAAAGA CTCACACACA AAAAAAACAA

78251 AACTACATAC TTCAATGTAG CAATCAACTT CAAATTTCTT AACAAAAGAT

78301 GGAAATGTTG GGGAAAAAAT TAGTCATCTG GTATCTTTCC CATTTCAACC

78351 TGCCTCCATT ATCTTGCAAG TGGTAAAATG CACAGAAATA AGCCTCAAAC

78401 AAGAGGGGCA GTCTAGGGCA AGTGAACACA TAAGTCGGAA GAAATTATGT

78451 AAAATGTTGC ATTTACTTAT TCAGTTTTCC CTTAGAATGA TTCACAAACT

78501 CTTCCTCATT CTCCCAAGTC CATTTTGAGT ATCATTTTCT TTGAAGAGAG

78551 TCTGATGGGC CCTGTACTAT ACAGTATGAA ATCTCTCTGT GGGAAATGAC

78601 TATCTAACAT AAATTTTTGT TTACACCGTT ACATGGTACC TACTTGCTTA

78651 TGCCATTACA TGATCAGTTT ACCTTTTTCT CAACCTAATC CAAGATCCTT

78701 CAATTGAGGC ACTATACTAT CTTTGTATCC AAAGCACCAA AAATGCTGCT

78751 TCAAACAGGC CCTAATAGAT AGGTGTTCCT ATACATATAC CAAAAAGACT

78801 TAACTTTTGG TGATCTTGTT TGTGAGTGTG GCTCATAAAC AGCTTAGTTG

78851 AGATAACTGG AGCCTCATGT AGCAGAGACA GTTGGACCCT GCTAACATTA

78901 CTGTGGATAT CTTCACATGT TACTACATTG ACTTTATATT CTGCTAATTA

78951 ACCAGGGACT ACAGTAGTTA AAATTATAAT TGTTTTCAAT GTTTTATGTG

79001 TAAATCTGTA TCTCACATAC TATCAAACTC TTCCTCACTG TCATCAGTCT

79051 ACTGCATTGA ATCCAACATA ACAAAGCTAA ATGACTCCTG AGGGCTGAAT

79101 CAGAAAGAAG AAAAGAAAGA GATACAAAAC TTTAGTCGGC CCGGTGGCTC

79151 ACACCTGTAA TCCCAGCACT TTGGAAGGCC AAGGCGGGCG GATCACGAGG

79201 TCAGGAGATC GAGACCATCC TGGCTGATAC AGTGAAACTC CATCTCTACT

79251 GAAAATACAA AAAATTAGCT GGACGTGGTG GTGGGCACCT GTAGTCCCAG

79301 CTACTCAGGA GGCTGAAGCA GGAGAAGCTT CTAAATAACT CATAAACACT

79351 AATTACTGTT GTGACACTTT AATTTTATAC AATATTTATA AGTATACAGA

79401 ATAACATTTC AGTGCTATTT TGGCACTCAA GGGTATTAAT GCATTAGAAA

79451 CACAGAAAAA AATAAATATT TGTCTTCATT GATAAAGTGT AATAACCAGC

79501 TTTTACAAAA CAGGTAATTT TTTATATTGT AACTCCCAAG GTATCTAAAT

79551 TTGTTTAGTG CATTAACAGA ACCCAGAATT AACTACAAAT ACAACACCTT

79601 GATAGTCTAA ATGTCCAAAC AGAAAGGTCA CGTAAATGTC GAAAGAAAAA

79651 GTACAATCAA TCTGTTGAAA AATGTTTATA ACAGCTCATT AACATAACTA

79701 ATTTCTGCTA AATTGTTAAA ATCTAAAATC GCTTATTTTG ATACCATATG

79751 GCAAGTTTTG CAGAAGCTTT TTGCACTAAA AATAATCTTG GCAGATAAAA

79801 TATAATGAGA GGTAAGTATG TAATAACAGA AAATAATTTA AATTGACCAG

79851 CTTCTCAATG TCTTTCTCAT TTTAGAAACA CCAATATGTT CTCTTAATCA

79901 TATCTGCAAT GAAAAATATT ATATTAGCTA AACTATTATG AAAAGTACTG

79951 GAATATATCT AACATACTAA TTTACAATAT CATATAAAGA TATCAGTGTA

80001 TAAAAGAAGG AAAATAAAAC ACTACATTTA GGAGAACGCT TTAAACCCAT

80051 ATGTTACAAT TAAATAGCTA ATGAAGAGCA CTCGGCATTA AAAGAAAATG

80101 TTTCCTATAT ATACACAGTC TGGAATGTAT CTTCCTAAAC CAAATAAAAA

80151 GTGCTTGTAA AATCATAGAC AATATCAAAG AATAGATTTC TACAGGGAAC

80201 TTCTCAAATG TCAACACTCT TATACACTAC ACATAAAAGA ATCAAACAAG

80251 TTAAAATATT AATAATATAA TAAGTAATAT ATAATACATA AGTAACAATT

80301 ACAAAGCTAA TTAACATTTG GGGAGGAGGG ATGAAGTAAA CAGCTCTTGG

80351 CCGGGCATGG TGGCTCACGC TTTTAACCCC AGCACTTTCG GAGGCTGAGG

80401 CAGGTGGATC ATTTGAGCTC AGGAGTTCGA AACCAGCCTG GGCAACATGG

80451 TGAAACTCCA ACTCTACAAA AAGTACAATA ATTAGGTAGG CATGGTGGCA

80501 TGCACCTATA GTCCCAGCTA CTCATGAGCC TGGGGTGGGA AAATTGTTTG

80551 AGCCCAGGAG GTTGAGGCTG CAGTGAGCTG TGATCATGCT ACTGCACTCT

80601 AGCCTGGGCA ATGAAAGTGA GAACCTGTCT ATAAAAATTA AAAAAAAAAA

80651 GCCCTTAAAT GGTTTATCAA CTAAATGGTT TATTTGAATC AATAATGAAA

80701 ATTCCTAGAC ACCATTTTTT CTTTTCACTT TTATTCATCA TTAAAAAGAC

80751 ACGGAGTAAG AAAAGGAAAA AAAGTAACAT GTTATAATAA TATTTTCCCA

80801 TATTAATCCA AGAACACAAT AACAACAACA AAAACTCAGT GAGAACTCAT

80851 ATTACCAATT TTAAGAATGA GTCTGAGGAA TTTTCAAAAC TTTTATTTAA

80901 TAGATTGAAA TAATCTGTCA AAATGTATCT ATAAAACACA ACAGAATGAA

80951 CAAAATTTCT GAGATTAAAG TTGTATCATT AAAAAATACC AAGAAGTTAA

81001 ATATTCCACA GTTCATTTAA TTAATTATCC AGTATTTATT CTGTACCAAC

81051 TATAGCAATG GTTTTAGGCT ACGTGCTCTA ATAAATAAGT ATTGTAAGGC

81101 TCCCCATGCT CCAAATTTGT TTTTAATCTT CACTAATCTG TTTTTCGTGT

81151 TAGGCAACTA GGATTCTCCC AGGATGCAGT AATAAAGAAC AAAGATGGAA

81201 AGCAAGAGAA AGAGGTAGAA TGACATGAAA ATCTGATCCA GAAGGTACAA

81251 CGTCTGTTTT ATATGAGTAC CAGAAAGGGA GAAAATAGGA GGGATTATAA

81301 TCACCAAAAT TCTAAAGGAA AAGTTATGTA TATATCTAAT AATAAAAGCT

81351 AACATTTAAT TAAACATAAT CCTCATTCAA CAGATGAGGA ATCTAAAACC

81401 CAAAGAGTCA TTATCACTGT TCCACTTATC TCTATATCCC TACAAAAATA

81451 CTCACTCTTG ATCTGTAACA ATGCCTCCTT AAACTCCCTG AATGGCAGCT

81501 TCAGGTAAAA ACTTCCCAGA AAGTTTGAAA CAACAAGGGT AAAAGGAAAA

81551 TTCTTGGAAC CACATAAAAA AGAAAACAGA TCATTACAAA AAAAGAAGAA

81601 TCAGGCATCA GTTCTCATTA CCAATACTGA ATTAAAAAGA AACCCCCAAA

81651 AAATCATTAT TTTCCTAGGT CTATAAAAAA TTATTTAAAA CCAAAATTTT

81701 AATGTCTGTT AAGCTAACAT TCAAGTCCAT GGATAACAAA TGTAAATGGG

81751 TTAAATTCTC TAGTAAAAGA CAGCAACTTT CAAAATATGC AAAATATACT

81801 ACTTAACACA TACACATATT TTACATGTAA CTATACTACA GACTTCATTT

81851 ATGTATGTGT GTGTGTGTAC ACATATATAA TATAAAATGA ATGAAATACT

81901 TTGGATATTT GTCCCCACCA AAATTTCATG TTGAAATGTA ATCCCCGATG

81951 TTGGAGGTGG GGCCTTATGG GAGGTGTTTG TTTGGGTCAT GGGGGCAAAT

82001 CCCTCATGGC TTGGTGCTGT ACTTGCAATA ACAAGTGAGT TCTCACAAGA

82051 TCTGGTTGTT CAAAAGTGTA TGGCATCTCC ACCCGTCTCC TTTGCTCCTG

82101 TTCTTGCCAT GTGAGATGCC TGCTCCCCCT TCTCTTTCCA CCATTATTTC

82151 AAACTTTTTT TTTAAATTTA TTATTTATTA TTATTTTTTT TTTGAGACAG

82201 AGTTTCACTC TGTTGCCCAG GCTGGAGGGC AATGGCCCGA TCTCAGCTCA

82251 CTGCAACCTC CACCCCCCAG GTTCAAGCGA TTCTCCTGCC TCAGTCTCCT

82301 GAGTAGCTGG GATTACAGGC ACCTGCCACC ACACCTGGCT AAATGATTTC

82351 AAACTTCTTG AAGCCCTCAC CAGAAGCAGA TGCCAGCACC ACACTTCCTG

82401 TACTGTCTGC AGAATCGTGA GCCAATTAAA CCTCTTTTTG TTATCAATTA

82451 CCCAGCGACA GGTATTTCTT TACAACAACA CAGGAGCGGC TGTATATATA

82501 TATATATTCA TACATATGCA CAATGTACAG TGACATACAC AATTCAAAAA

82551 CAGCCTTGAG GGGAAAAAAC ACAAACGCTA TCCAAAAAAT GCAGGTATAG

82601 CAATAATTGC AAAGAAACAG AATTTAAACT AAAAAGCAGT GAATAAGTCA

82651 AAGATAATAA TTCACAATAA CATAAGTTTT ATGTTACAGT GTAAATTCCA

82701 AAAGAAGCCA TAGTCATTAA AGTTTATACA CCTAATAAAT ATATGTCACA

82751 TATAGAAAGT AAAGCTGAGT AGAAATAACA TGCATAGATT AGACTTTAAC

82801 ATAGCTCTCA AATCAGGATA TTAAATAGAT ATGAAATAAA TAATAACAAT

82851 GATCGGGTTT GATTCAAACA GACACATAAA ATACACACAG ATCTCTGAAT

82901 TCCAAAAATA GAGAAAACAT TCTATTCAAA TGTACACAGA ATTTTCAAAA

82951 AAAAATTCAC ATGTATGGTC ATAAAGAAAT GTCCACATAT TTTAAAAAGC

83001 AGGTATTTCC TAGGTTATAT CCAGTAAAAG CAGATGCGTC CCTAGACCTA

83051 ATACAATAAA AATTAGAAAT TCACAATATA AGGATAAACT CCCAAATCTA

83101 TCCACTGGCA AAATTTAAAA GTCCTTTCTA TATAACGGCA GAGTTTCAAT

83151 CAAGAAGAAA AATCATGTAT TATTTTTAAA TGATTAAGGA AACATCAAAA

83201 AAATCTCTGA GACGTGGCAA ATGTGGTATT CAGAGGAAAA AAATACAGCT

83251 TCAAACATGC AAAACTGTAA GACTAAAGAA TTACAATAAA TAATGCCCTA

83301 TTCAAAAATT AAGCCAATAA GAATCAACAT ATAACCCATG AGATTCGCTA

83351 TCTAGGGAAG TAAACCCACC CTAATACTGG GTTTATTAAA ATGCTGTAAT

83401 GAGATCGGAG GGTTAAACAA CTTTTCGGTT TAGGAAGTGA AATAAAGCTG

83451 ACTGAAATAA AACCTAATCT ATGAAATTAT TCTGTATATG AATTGACCTG

83501 AAGTAATGAA CAGTTCAATG ACTGACTCAT GACTCTTGTT CTGGTCCAGG

83551 CTAATCATTC TAGTTGGCAT ACTATTAAAC ACACATTTCT GATTGAAACA

83601 TCTGCTAAAA AAATAACATC AAACGACATT ACAAAATCAA AATGGAAACT

83651 GCTAAGAGTG GGATTTTTCT CCTGCCAGTA TCTTTCCTTT CTGCCACATC

83701 CTCCTCCCTG CTGCCACAGC AATCTTTCTA AAGGAATACA AATATATTCT

83751 GAATCACACA CAAACCCCTC AATACAGAAT GTGTGGTAGG CAGTATTCTA

83801 AAATGCCCGC ATACCACCAA CCCCACCAAA TTTCCTACCC TAATACAGAG

83851 GCTGTAAATA TGATGAAATA TCACGGCAAG GTAATGCCAT TAATATACTA

83901 TATGGCAAAG GAATTCTGCA GATGTGATTA AAGCCATCAA TCAACTGCCT

83951 TTGAATTAAT CAAAAGGGAG ATTTGCCTAA TCTAATCAAA TAACCTCTTT

84001 GAAAGCGGAG TTTTATCCAG CTACTAGCAA AAGGGAAATT CATAGCAAGG

84051 GAACATTTCA GTACACTGTT GCTATGTTTG AAGATTAAAA GAGCCAGGAG

84101 CAATAACCAA AGAGTGGCCT CTAGGAACTG AGGGTGACCC AAGCCAATAG

84151 GCAGTAAGAA AATGGTGAGC TCAGCAGGGT GTGGTGGCTC ATGCCTGTAA

84201 TCCCAGCACT TTGGGAGGCC AAGGCAGGAG GATCACGATG TCATGAGATC

84251 GAGACCATCC TGGCTAACAC GGTAAAACCC CGTTTCTACT AAAAATACAA

84301 AAAAAAAAAA TTAGCCGGCA TGGTGGTGCA CGCCTGTAAT CCCGGCCACT

84351 TGGGAGGCTG AGGCATGAGA ATCACTTGAA CCCAGGAGGC AGAGGTTGCA

84401 GTGAGCCGAG ACTGCACCAC TGCACTCCAG CCTGTGCGAC AGAGCAAGAC

84451 TCTGTCTCAA AAAAAAAAAA AAAAGAAAAG AAAAAGAAAA TGGCAAGCTC

84501 AGCCCTACAA CTTCATAGAA CTGAATTCCT CCCACACCTG AATGCCCCAG

84551 AAGAGGATTC ACCCCCGGAG CCTCACCCAG GTAACACCTT GATTTGAATC

84601 CTGTGAGACC TTAAACAGAG AGCACAGTTG AGCCTGCCCT GAGTTCTGAC

84651 CTAAGTAAAT GGGTGCTGTT TTAAGATATT AAGTTTATGG TAATTGCTTT

84701 ATAATAATAG ATAACAAATA GAGCAGCATT TCAAGGCCCT CCCTGCTTTG

84751 GTCTCTGCCA AATCACTATT AGATTTTTAA GATTTTTTTT TACACATTAT

84801 ACTTACATTA CACAATGTCT TAACACTATG AAGTAAAAAT GTAAATATTT

84851 TAAACTCTGG CTTGGAAATG AGGAGGCAGA ATCTCAGAAA TTTTCCTAAA

84901 ATAAAATAGG AGAGGCAAGC TTTCTGAGTC CACAAAAATG CCCTCTACCT

84951 ATTGGGTCAA AGAAAAAGTA ATTTCTCTAT TTGTAACAAC ATACATAAAT

85001 TATAAACCCT GAAGAAATAG GTCCCTAATA GCTATAATCT TTAACATAAC

85051 CATAAATAAA AACATGAATA AATCTGACTA CATAAAAATG TAAAAACTTC

85101 TATGTGGTGA GAACACACAT TACAGAAAAA AAATCAAATG ACAAAAAATA

85151 ACCTCCAATT TGGATTACAA ATATCTAGTA TCCTGGATAT ATACAAATAA

85201 AGCATGTAAG TTATAAAAAT GAGTATAATT TTAAAATAGA CAAGGATACT

85251 TTATAGAATT TCATAATTTA AGGAAGACAT AAAGTTAGCC AATAAACTAT

85301 GGGTAATATG CAAGAATCAG TAAGCATTAT TATTTGCCAG CAGCTAAGCC

85351 AAGTACTTTA TAAGAATTAC TTTATTCCCA TCTATGCCAG GCACAGTGGC

85401 TCACGCATGT AATCCCAACA CTTCGGAAGG CAGAGGTGGG TGGATCACCT

85451 GAGGTCAGGA GTTTTAGACC ACCCTGGCCA ACATGGTGAG ACCACGTTTC

85501 TATTAAAAAT ACAAAAATTA GCTGGGCCTG ATGGCCAGGT GCCTGTAATC

85551 CCAGCTACTT GGAAGGCTGA GGCAGGAGAA TCAGTTGAAC CCAGGAGGTA

85601 GAGGTTGCAG TGAGCCGAGA TCATGCCACT GCACTCCAGC CTGGGCAACA

85651 GAGTGAGACT CCATCTCAAA AACAAAAACA AAAACAAAAA CAAAAACAAA

85701 GAAATTACTT TATTCCCATC TAACCACAAC CACTTTAGGT AGATATCACT

85751 ATTTTTCATT TTACAAATGA AGCAGAGAGG TTAAATTTCC TTGTTCAAGT

85801 CCATAGAGTC AGGAAATGAA AAAGGAACTG AACTCAAGGA GTTCATAATT

85851 ATTTATATAC AAGTAATAAA GACAAATTCA TTGACTATGG AAATGTACTG

85901 AGTATTTTGT CTTGTTTACA TAATGGTTTT TATTTAGGTT GTAAGAAAAT

85951 AACATATAAC CAGGCACGGT GGCTCGTGCA TGTAATCCCA GCACTTTGGG

86001 AGACCAAGGC AGGCGGATCA CTTGAGACCA GGAGTTCGAG ACCAACCTGG

86051 CCAACATGGC GAAACCCCAT TTCTACCAAA AAAATACAAA AATTAGCCAG

86101 GCGTGGTGGT GCACACCTGT AATCCTAGCT ACTTGAGAGG CTGAGACAGG

86151 AGAATCGTTT GAACCCGGGA GGTGGAGGTT GCAGTGAGCC AAGATTGCAC

86201 CACTGCACTC CAGCCTGGGT GACAGAGCTG GACTTTGTCT CAAAAAAATA

86251 AAAAATAAAA AAGAAAGTAA GAAAAGAAAG TAGCCACTTT GGGGTTAGAA

86301 TCCATAATAC TCTCAGTGTC AACCAAAAGA AAGGTACTGC AATGTTCACA

86351 GAACACAATT CATAATGACC TCAAATTGAA AGTCCTCAAA ATGCCCAACG

86401 GTAAAATAAA TAATTTATAG TACTCTTAAC AACAGAATAC TATATATCAA

86451 TGAGAAAAAT AAACGACTGG AAGGAACAAT TTGGATTTAT CTCATAAATA

86501 TATACGTGAA AGATGACAGA AAACAGTACT TAGTAGCTCA ATTATACGAA

86551 GTACAAAGCC AATTATGCAA AGTACAAACA TAGGCAAGAC TCACCTATGT

86601 TGTTACTAGA TGATAGTGCA TGTCTCTGGG GAGTTAGGAA TAGCAGCCAA

86651 CAGGAGGCTT GAATGGAATA TCTGGGGCGC TATTATTTGT TTCCTGATGT

86701 GATTTAGTAT ATAGGTTCTA ATATTTTGGG TATTCCTAGA AATGTGTACC

86751 TATTATTCAC TTGCTCTATA TATAGAGAGA GCTATATAGC TCTCTCTCTA

86801 TATATATATA TAGCTATATA TATAGCAAAG TGAATTTTAT ATATAATTCT

86851 TCAACATATT TTTAGAAAAA TTAAGTTTTT TTAGAAAATT AAGAGAATTT

86901 TAGATAAAAA CTCAACTTTT AATGGAAAAT ATTGCCTTTT TCTTTCTCAC

86951 ATGAAATCCT CTATCAAGGT TAGTATCCTA CCTGGCATCT CTCCAATACT

87001 GGGTTAAGAG TTTTTCTTCT CAAGTAACCT GTATTATATT AAGATGATAT

87051 TAACTGAAAT AATCAGATAG ATGACTGCGC CATAAAGCTA ATTCTAAGGT

87101 ATCTGTCCTT AGCCAAAAGC AGAAAAGGGA TACACATAAC TTCCACATAA

87151 AACATCCACC CCCATTTCTT TGGTTATTCT TAAAAGCTCA TAATGTATAC

87201 AATGATAAAA TTTATTGTTT CAAATTAGGG TTTTTGAAAT TGAAATATTA

87251 ATTTAAACAC GTTTGCTTAA CACAACTTTA AAGTTAATAA GAAAACACTG

87301 CATATTACAG AAGAGTTAAA TACTTCAAAA AGTGGGAAAG AATTTAAAAG

87351 CTTTCACTTG AGTAGGAGTA AACACAAACA CACTAAGAAT CTAGTTGGAT

87401 ACACTTAAAT CATGTCTTTT AAGAACATAA GAACAGATTA TTTGCTTTCT

87451 CTTTAGTCCA AAACCTTGGT GTAATTTTAG TCCAAATTTG AAACTAACAG

87501 AAGAATACTC AGCTTCTTAA AAGTTTTATT TCAAGAACAG TAAAAGAACT

87551 TCTGGTCTTA CAAACATTAC ACAGATAAAA CGAGTTTCTC CAAACAGATG

87601 TATGTAAAAA TCTAGTACAT ATACCCCCAA GTTGAGTCAA TAAGGTGAAC

87651 CAGATTCTGG TTGAATGGAA TCCTTGAAAT ATAACTTTGG TGAACAAACT

87701 GTTTGTGTTT TCCACTTTTC TTAAAAAAGA AGTGATAAAG CAGATTTCCA

87751 GTAACTGCCA GCTGACAAAA TGCTACTTAC CAGGTAAAAA CCACTACCAA

87801 AAATCAGAAT CACAGAAGAG CTATCAGTAA AATTATTAAT GCCACAAATT

87851 AACATGATGT TAACAGCTGA TTTATGCATC AAAAGAGTAT TTATATAATC

87901 ACAGCAAATA ACTCAAATCT TTTACATCAC TAGTAAACTC AAAAAATATA

87951 GCAAAAAGCA ATAACATTAA ATTTCATTAT TGATCTACTA GCTTTAACTA

88001 TTTAATACTA GTACACTTAG TTTTGATTAC TTTGAAATTG AAGCAAAAAC

88051 AATAATCTTT TCTTCTTTTA ATGACTTTTT CAGTTATAGG AAAGATGACA

88101 TTAAAAGAAA ATATACAACT ATAGCTTAGC TACAGGTATA AAATTGTTTT

88151 AAAGATATGT AATTGTGCTA TTGAATTAAA CTGAAAACAT AACTATCAAC

88201 TCATGATTTT GAAAAAAAAT CTTTTTTATG TTTGGTTTTG GTAAAAGGAG

88251 AGACAAATAA GTCAGAAGAA CAGAAAATAC AGAAATAGGC AAACTTTCCC

88301 ATATTCAATT AATTTTTGAG CAAGGGGCCA AGGTAATTCA AGAGAGCAAT

88351 AAATAATCTT TTAGAATGAT GCTGAACTGC CAAATAATTC ATATGGAAAA

88401 CAAAGAAACA TGAATCTTAT CTTGTATTCT CTTATCATAT GTGTAATTTA

88451 ACCATAAATG GATTTTTAAA CCTACAAGTA ACACTGCGGC AAGCAAAGAT

88501 TTTTAATAAA GCATAAAGAG CATAATTTTT TCAACTTCAA AAAATTAACA

88551 AATGACAAAT GTCATCAAAA TGAAACCCTC TGCTGTTCAA TAAACATTGC

88601 TAAATAAATG AAAACAAGTC ACACATTAGG CAAAAATATT TATAAAATGC

88651 ATCTCCAATA ACTGACTTCT GTGAATAATA TATAAAAAAA ACTTAGAACT

88701 CAAGAAGATG ACAAGCAAAT CAATTGGAAA AAAATGGTGG TAGAGACAAA

88751 ATCTTTAACA GACATGTCAC CAAAGATACA CAAATGGCAA AAAAAGACAT

88801 AAAAAGAGGC TCAATCTAAT TAATCATCAG AGAATGCAAA ATCAAACCCA

88851 CAATAAATTG CACTAAATGC CACCAGATGG CTAAAATTTA GAAATAGTGG

88901 CAATAGCCAA TGCTGGCAAC AATGTACAGC AAATGGAACT CTCAGATCTC

88951 TAGAAATGGA AAAGTATACA GACACTTTTT AAGAAACTGC XTGAAACTGT

89001 TTTCCAAAGT TAAGAATATT ATTTCCAACA AGTCAGAAAT TCCAGTCCTA

89051 GGTATTTACC CAAGAAACAT GAAAAGATAC ATCTACAACG AAGCATGTTA

89101 CATAAATGCT CACAGCAGCT TTATATACTG GCCAAAAATT GAACGAAACT

89151 TAACTGTAAG CTAGTGAATG GACCAATCTC AAAATGATTA TGCTAAGCAA

89201 AAATAAGGCA GATGGAAAAG ATTCTATACT GTATGGTTCC ATTCATATAT

89251 TAGTCTAGAA AAGGCAAAAC TATAGGAAAG CAACAGATCG GTGATTGCCA

89301 GGAGCTGGAG TGGGAGGTAG GCAGTAACTT CAAAAGGTCA TGAGCGAATT

89351 TATGGGTAAA GGGTCTATTC TGTATCTTGA CTATGATGGT AATTACATGA

89401 CTGTTCATAT TTACCAAATC ACATTCAATA CACACCTTAG AAAGGGTGAA

89451 TTATAGTGTA TGCAAAATAT ACCTTAACAA AACAATGACT CTACACATAA

89501 CTTTATTTAT TTATTGGGTA ACAGCATAGG GACTAATATC AGAATAACTT

89551 TCCTAAAATG TCTCAAATCT GAAGAAAATG TAAAAGCTAA CTAATTGAAG

89601 TTACCTGTAA ATAACCAAAA ACTGGCTGGA ATGGGAGGAC ATTTTACCCT

89651 TGGAAAAAAA GCGGAATGTC ATTGGCTAAA ATCTATATTT AAATAGAGTT

89701 TCAGTCTGGG CACGATGGCT CCTGCCTGTA ATCCCAGCAC TCTGGAAGGC

89751 CGAGGAAGGT GGACCACCTA AGGCCAGGAT TTTGAGAGCA GCCTAGCCAA

89801 CATGGTGAAA CCCCACCTCT ACTAAAAATA TAAAAATTAG CTGGGTGTGG

89851 TGGTGGGCAC CTTATAGTCC CGGCTACTTG AGAGGCGGAG GCATGAGAAT

89901 CGCTTGAACC TGGGAGGTGG AGGTGGCTGT GAGCCGAGAT CGCGTCATTG

89951 CACTCCAGCC TGGGCGACAG AGACCCTGTC TCAAAAGAAA AGAAAAGAAA

90001 ATTCTACAAC TAATAAGTAT AGTAATTTCA ATGAAAATTT TAGTGGATGG

90051 GCTTAACAAG AGATTGGTAG AAAATTGGTC CATCTCCTTG AAAATACATG

90101 AATAGTGTAT CTATTCTGAG GAACTAAAAG TAAAAACACT GGGAAGAAGA

90151 TGAACAGACC CTCAGTAATC TACAAAATAT CAAATATACT AACATTCATG

90201 TAATTAGAGT TACAGAGGAA GAGGAGAGAG AAATGAGACA GAAAAAGAAT

90251 AAGAAATAAA AGTCAAGCTT TTCACAAATT TGGTGAAAAA TATCAACTTA

90301 CACTTTCAAG AAGCTCAGCA ACCCCCAAGC AGGATGAACA CAAAGAAAAC

90351 CACACCTAGG CACATCATAG TCAGACTGCT GAAAACCAAA GATAAAGAGA

90401 AAATCCTGAA AGCAGCCAGA GAATATCAAA ACATTATTAT ATACATGGGA

90451 ATAATGATAC TACTGACACC ACACCTGACT TCTTATTAGA AACCATGGAA

90501 GACAGGAAAC AATGCAACAT CTTTTAAATG CTTGAAGAAG AAAAACATAA

90551 TCATCCCAGA ACTCTATATT CAGGGAAAAA AAGGCAAAAA TGCATGCAGA

90601 CTTCCACTTC CAGACAAAAT GCGAGAAAAT GTACTTTCCC TGTTCTTTCC

90651 ACTAAATACA GCTTTAAAAA CCCTTGGCGG TGATACATAA GACAAACAAA

90701 GGAAGACAAC AAAATGTAGA GAGACGGCAG ACCAATTAGG GCTTCAGGTG

90751 CCAAGAAACA CAAGAGGATG AATTCCCTAG GTTTCCTTTC TGACTCATAT

90801 ATACAAAAAA GTTGCTAGAG AAGCAGACAA CTCAGAAACA CCAACAGGCA

90851 CACACATACG TAAAACTCCA AGAAAATTCT GCTGTCTCTT GTCAAAAAAG

90901 CAGGGAAGCG GCAGGCTACT AAGAAAAAAA AAACTCACAG ACAACAACCA

90951 ACCAGTTTAA GCCAAAGGGG ACAAATAAAA CCCCAAGCCA TATACCTTTT

91001 GCAAAGACTT AAAAGGAGGA CATAGTCAGC CATTCCCCAC TCCTACCCAC

91051 AGACAACATG ATACCACAGC AGGCCAAGGG GGGACACAGG ACACTCATAC

91101 CCACTGAGCA GCAACGCGGC TTCCTCCCTC TAGAGTGGGA GTGGAAAAAA

91151 AGTGGGGAGC CTGAGTTCAA CACCCACCCA ATGAGAAGGG CATATTCCTA

91201 TCCCTCCCTC TACAGAGATA TGACAGCAGA GGCCTACTGG AGAATCCAAA

91251 CTCAAAGCAC TGCTCAGTGA TAACTTAACC ACCCCTCCAT CCCAGTGTCA

91301 GTGGAGGCCA AGTGAAAAGC AGGAACCTTT TGAGCCAGGG TGGTATTCAC

91351 AAAGGTATAA TGCAAGTCCA GAGTTTTCAT TCCTACTCAG CATTTACTAG

91401 GTGTACGTCT CCATCAATGA GTCAACAAAG GCCTACTATG AAACTGGAAT

91451 CTTCACATAC ACCTGGGGGT AGTAACAAGG CTATGCCCCA CCTCCACCCC

91501 AAAAGCAAAT TTTCAGATAA ATCCTACTAA AAGGGGGGAT TTAAATAAAA

91551 TGCAGAGCTT CATAACACAA CACTTAAAAT GCAAAGGATT CAACCAAATA

91601 TAACATGTCA TACCATACTA AGAAGCAGGA AAATCTGAAC AGGAATTTGA

91651 AAATATAGTC AAAAGGTGCA AACAATGAGT ATTCATAGAT GTCATAATTA

91701 TCTATCAAAG ATTTTAAACT ATATATTATA AAACTGCTTC AACAAGCAAT

91751 TACAGCCAGA CACAGTGGCT CACGCCTGTA ATTCCAGAAC TTTGGGAGGC

91801 AGAGGTGGTT GGATCACTTG AGGTCAGGAG TTCGAGACCA GCCTGGCCAA

91851 CATCGTGAAA CCCCATCTGT ACTAAAAATA CAAAAATTAC CCAGGCATGG

91901 TGGTTCACAC CTGTGATTCC AGCTACTCGG GAGGCTGAGG CATGAGAATC

91951 ACTTGAGCCC AGGAAGCAGA GGTTGCAGTG AGCTGAGATC ATTCTACTGC

92001 ATTCCAGCCT GGGCAACAGA GCAAGAGTCC GCCTCAAAAA AAAAAAAAAA

92051 AAAAAAAAAG CAATAACAAA CATAATTTTG AAACAAAGGA AACAATACAA

92101 TGTTTCGCAT AGAAATCAAG AAAGAAACAA ATACCAAGTT GAAAATTAAA

92151 AAATATGCTA GCAATAATAA AATACAAACT AAAGCTGAAC ACAAAATGGG

92201 GGAGATTACC CAACCTAGAG AAGAAAATGA ACTGATTAAA AAAAAAAAAA

92251 AGTGGCCAGG TGCGGTTGCT CAGGCCTGTA ATCCTAGCAC TTTGGGAGGC

92301 CGAGATGGGT GGATCACCTC AGGTGAGGAG TTCAAGACCA GCCTGGACAA

92351 CATGGCAAAA CCCTGTCTCT AATAAAAATA CAAAAATTAA CTGGGCATGG

92401 TGGCACACAC CTATAATTCC AGCTACTCAG GAGGCTGAGG CAGGAGAATC

92451 ACTTAGACCC AGGGGCGGAG GCTGCAGTGA GCTGAGATTG TACCACTTCA

92501 CTTCAGCCTG GGCAAAAGAG CAAAACTCTG ACAATAAATA AACAAATAAA

92551 TATATATATA TTTTTTAAAA AAAGGCATTA AAGACACTTG TGGTACTATA

92601 ATAAATGATG CAACATTCCT GTCACTGGAA TCTCAGAAAA GGAACATGAT

92651 GCAGCTGAAC AATTATTCGA AGACCCACAG ATTCAAGAAA TTGAATAAAT

92701 CCTAAGAGGA TACACACAAA TAAATCAATG CTAATATATA TCATAAACTT

92751 NTGAAAACTA ATGACTAAAC TTAAAAACCT TGNGATAAAT AAGAGAAATG

92801 ACACCTTATC CACAGATGAA AAACAACTCA NATGACAGCA GATTTCTCAC

92851 CCGAAACCAT GGAGGCCAGA ACAAAGCAGC ATAACATTTT TGTAAGTCCT

92901 AAAAGAACTG ACAACAAAGA ATTCTATATC CAGCAAAAAC ATCCATTAGT

92951 AATGAAAGGG AAATCAAGAA TTTGTGAGAT GAATGAGAAC TAAAAATTAG

93001 TCATGAGACA AAACTACACC AAAAGAATAG TGAGAAAAGT TATTGAACCA

93051 GAAAGGAGAA TGATAAAAAG AAGGATTCTT AGAACATCCT GAAGGAAGAA

93101 AGAACAAACA AATAGTAAAA CTATGGGCAA TAAAACAGAC TTTACTCTTC

93151 CTTGAGTTTC CAAAATAATG TTTAACAATT GAAGCAAAAA TTGTTACATG

93201 ATGCAAAAGC TATGGTGGGT AAAACTGTTG ATGCATTTCC AAAACTGAAG

93251 GCAGCTGGCA CCAAGCTGTA TTAGAAGTTG TCACATTCTC AACTGGTACT

93301 ACAACTACAG TAAAAATAAT GTAGAGTATC ATTGAGAATA TCACTGATGA

93351 AGCAGCAAAA ATCTTTAATG CTTTAAGTCT TGATCCATGA ATACACCATC

93401 TTTTAATTAT CTATGTGACA AAATGAGAAA TGAAGCGTAA AATAATTGTT

93451 ACACCACAGT TTTTCTTGAG GAAAGAATTT GTGATCATGT GATTTATAAA

93501 CTGAAATAAC CTGCTTTTTT AATGGAACAC TGTTTTTACA TGTAAGAACA

93551 ACTAAGAAAC CACAATTATT AAAACTTGAT TATCTGACAT ATTTCTTCAA

93601 AAATGAATAA AGTGAGCCTG CCACTTCAAG GAAAACAACT AACATGAGTG

93651 GACAATAAGA AGATTTGAAA ACCTTACAAC CAACAATGTA AGCTTAACTA

93701 ATTCCAATAC TTAAAGACTT TTCTGATGAG AGCAGTTGAT TATAACAAAT

93751 GTGAATTTTT GTTATTAACT AAAAATGTGT AGGGACTAGG TAAGCTGGCT

93801 ACACTTGTAA TCCCAGCACT TCGGGATCAC TGGAGGTCAG GAGTTCAAGA

93851 CAAGCCTAGC CAACATAGTG AAACCCCATC TCTACTAAAA ATATGAAAAT

93901 TAGCTGGGCC TGGTGGTGCA TGCCTATAGT CCCAGCTACT CAGGAGGCTG

93951 AGGCATGAGC ATCACCTGAA CCCAGGAGAC GGAAGTGAGC TGAGATCGCA

94001 CCACTGCATT TCCAGCCTGG GCAACAGAGT GAGATTCTGT CTCAAACAAA

94051 CAAAACAAAA CAAAACAAAC AAACAAAAAC AACCGTATCA ATAGTTGGAA

94101 TATCTGGATC ACTCAGTGAA CCAATATTTT CCAAAGACCA CTTAGTAATC

94151 TTATAAAATC ATATATGGGT AAAAGATCCC CTGAAATTGC AAGGTAGTCT

94201 AATAAATTAT ATATATATAT ATATATATAT ATATTTTGTC TCAGAGATAA

94251 AGTCTCACTC TGTTACCCAC GCTGGAGTGC AGTGGCACAA TCTCGGCTCA

94301 CTGCAACCTC CACCTCCTGG GTTCAAGAGA TTCTCTGCCT CGGCCTCCCC

94351 CGTAGTTGGG ATTGTAGGTG CCTGTTACAA TGCCTGGCTA ATTTTTGTAT

94401 TTTTAGTAGA GACGGGGTTT CACAATCTTG GCCAGGCTGG TCTTCAGCTC

94451 CTGACCTCGT GATCCACCCA CTTCAGCCTC CCAAAGTGCT GGGATTACAG

94501 GCGTGAACCA CTGCGCCCAG CCCATAAATT ATAATTTTAA AGGATAAAGA

94551 TATAAAGTTC ATTGATGGGA TTGCAGTCTT CAGACTGCAC CAAACCACTT

94601 GAAAAACTTG AGAAACTACC ACTTCTCAAG CTTTGGTTTT AGTATCAAAC

94651 AGGAATATTC ATTAGGGCTT GTGCTTTCAT TCTTACAGTA TATTTTAATA

94701 AACAGAAGTT ATTTCTCAAA TGTAGTTGAA TGCTCCAATA TTTTCCTTTA

94751 CGTTCAGTGC TGTATCTCAA GAACTCTTTT ACAAAAATAT TATCCTATAT

94801 TATCTTTTTA AGTATAAATA AAAATAATTA TCTTTTTAAA AGCTTATGAG

94851 TTTAGGTGGA AATATGAAGG GCCAAAAGGA ATTGGAAGAC ATTTTCCTAC

94901 TATTTGTTCT TTCTCTTGAT TTTCATGATT CATTATTCTT GTAGAAGTGA

94951 CCTTACCACA GTATAAGGTT CACTTATAAT CACTGTTCTG CCTTGTAATT

95001 TTAGGTGAAT TTGTTACAAA ATATTATGAA ATCTATAGGA AAAGCCAACT

95051 TTCAAAGCTA TTAAGCATTT GACTTAACAG TTGAGGGCAA TATTATTCAG

95101 AAAAATTTCA ATCTCATTCC TCAGCGCAAA AAACTGAAAT AAAACTTTAC

95151 CACTGCCAAG TCAGTAAATT GCTATGTAGA ATGGCAATTC AGTATATTCT

95201 GCCTCTATAT CTAACAAAAA TTCATAGGAT TTGATGATGA AGTCCACAAA

95251 TGCCAGTCAA AATCACTGCT GACACTATTA TATAATAGTT CACTAAAACA

95301 TGACAGATTT AAATATTTTC TGCAAAGTAC CTGCTAATAA ATAATACAAT

95351 AAATAATCAG GCTTTAAACA CCTGACATTT AACAAGCTTT GTAAATTTGT

95401 CCAACTCAAG TCTTTCTGCT CCACAGTTAT TTTTGCCACT ATCAACTGTA

95451 ACACATCTTA GCGGATTCCA CTTCAGGTTG TACTAAGTTA GTGTTTGCTC

95501 AACTTTTCTG AAAATATTTT CTCTTGTAGT TGTTTCACAT AGACTATGCA

95551 TAAACACTAA TTCTTCGGCA TCTTCAAACT CAGCACTGAC TTCTGGAATA

95601 TGTAACAACT GAACAGTACT GGTACTGGTA ACACCTATTC ATCCATCAAA

95651 AGCCTAAGAA ACTCCATGAA AAATCATTCA CCCTTCTTTC CAAAATGGCT

95701 TGATATTACT CCCAATGTCC TTAACTTTTA GAGCAATTAC TCTCGCTGAA

95751 AGGTTAATAG TCTTTTTAAA AGTTTATTTT CTATGGACAC ATCTTTGGTT

95801 ACCGTAATGA AACATAATTT AATTACCTCC TGTTGGTCAT GGTTTTCCTT

95851 CCTTGGCTCA CACATCAGCC ATTGAAAAAA CTTACTTTAA TTATAGCCTA

95901 ATTTCCATTT TTTGTTTTTG AGAAGAAATT CTGCTGTGAT AAAATTTTGT

95951 TTTAATTTAC TATTTTTTTT CCTACCTTTT AGTTAAGTTA ATCCCTGTGG

96001 TTGGGAAAAT TGTAAAAGTG CCCATTCTGG CAATGTTGCC ATATATAATA

96051 TTCTTTTAGC CAGCCATAGT CTTCTAGCAT AACCAATATA ATGCTTTTGC

96101 TATCTAATTT GTTAATAATA ATATACATTC CACTATGCCA ATAAAGTGTT

96151 ACATATAAAG TCCACTTTTC TCCTTTTCTT GTTTTAACAT GATAGGTAAG

96201 TATGCACTGG TAATGAGAGA AATAAATAAG ATGCCAGGGC AATATGTGTG

96251 GTGCACACAC ACACACACAT ACTGACAAAC AGTAACTATG TCATTGTGAT

96301 TCGTAGCATG CAGAGCAGCA ATTTGAAATA TATGTGCTCT CTGCAGCAAC

96351 CAACTCTGAC ACTGTAGTGC AACGGAAGTC ATATATAATG CCCAAACAAT

96401 TCAGGGAAAG GAAAAGTCAC GTGCCTCTCA TTTTAACTGA AAAGCTACAA

96451 ATGATTAATC TTAGTGGGGA AGGAATATCA AAAAGTGAGA AAGGCCTAAA

96501 GCTAGGCCTC TTGTACCACT CAGACAATTA TGAATGTAAA CGAAAATTCT

96551 TGAATAAAAT TAAAAGCACT ATGTCAGTGA ACATGAAACA ATCTTATTGC

96601 TAATATGAAG AAAGTTTTAG TGGTCCATAT GAAAGATCAA ACCAGCCACA

96651 ACATTCCCTT AAGCAAAAAA CCTAATCCAC AGCAAGGCTC TAAGCTTCTT

96701 CAGTTCTATG AAGGCTGAGA GAGGTGAGAA AACTGCAGCA GAAAAACTGG

96751 AAGCAAGTAG AAGTTGGCTC ATGAGGAAAA ATGCTCTTGT CATAACATAA

96801 AAGTGGAAAG TGAAGCAGCA AGTGCTGACA TGGAAGCTGT AGCAAGTTAT

96851 CCAGAATATC TATCTAAGAT CATTGCTGGA GGTGGCTATA CTAAACAAGG

96901 TGTTTTAAGT AGACAAAAGA GCCTTCCATT AGAAGAAGAT GCCATCTAGG

96951 ACTTTCACAG CTAGAGAGGG AAAATCAATG CCTTGCTTCA AAGTTCAGGC

97001 TGGGGCCACA CCTGTTATTC CAGCACTTTG AGAGGCCAAG GTAAGAGAAT

97051 CACTTGAGCC CTAGGAGTTC AAGGCGAGCC TGGACAAAAA GGCGAGACTC

97101 TTGTCTCTTT TAAAAATAAA TAAATAAATA AATAAATAAA TAAATAAATA

97151 AAAACTGACT CTCTTGTTAG GGGCTAATGC AGCTGGTAAC TTGACGTTGA

97201 AGCTAATGCT CATTTGCCAC TCAAAAAGCC CTAGAGCTCT TAAGAATTAT

97251 GCTATATCTA ATCTGCTTGC TATCTACATA TGGAACAACA GTCTCCTGGA

97301 TGACAGCACA TCTGTTTAGA GGTTGGCTTA CTGAATATTT TCAGTCCACT

97351 GTCAAGACCT ACTGCTAAGG AAAAAACATT AATTTCAAAA TATTAGCACT

97401 CACTAACAAT GGACCAGGTC ATTAGAGGGC TTTGATGGAT ATGTTCAGAA

97451 AGAAGAATGT TACTTTCATG CCTGCCAGTA CAATACAACA TCTATCCTGC

97501 AGCCCATGCA TCAATGAGTA ATTTCAATTT TTAAGTCTTA CTGTTTAAGA

97551 AATACATTTC AGCCAGGCAC GGCAGCTCAT GCCTGTAATC CCAGCACTCT

97601 GGGACACAAA GGCAGGAGGA TCACTTGAAG CCGGGAGTTC GAGAACACCC

97651 TGGCCAACAT GGCAAAACCC CATCTCTACT AAAAATACAA AAATTAGCCA

97701 GGCGTGGTGG CACCCACCTG TAGTCCCAGA TACTCGGGGG GCTGAGTCAG

97751 GAGAATCGCT TGAACCGGGA GGCAGAGGTT GCAGTAAACC AAGATCACAC

97801 CACTGCACTC CAGCCAGGCT GAGAAAGCGA GACTCCATCT CAAAAAAAAA

97851 AGTGATTCCT GTAGTAGATT TGGGCAAAAT AAACTGAAAA CCTTCTGGAA

97901 AGGCTTCACC ACCGTAGATG TCATTAAGAA CATTCATAAT TCATGAGAGG

97951 AAGTCAAAAT ATCAACATGA ACAGGTGTTT GGAAGAAGTT GATTCCAACT

98001 CTCATGGATG ACTTTGAGAG GTTCAAGACT CAAGTGGAGG AAGTCACTGC

98051 AGATGTAGTG GAAACAGNAT GAGAATTAGA AGTGGAGCCT GAAGATGTGA

98101 CTGAATTGCT GCAATCTCAT GATAAAACTT GCACAGATTA GGAGTTGTTC

98151 CTTACAGATG ACCCAAGAAA GTGGTTTCTT AAAGATGGAA ACTACTCCTG

98201 GTGAAAAGGC TGTGAAATTA TTGAATGACA ACAAAGGATT TAGAATACTA

98251 TATAACGTTA GTTGTTAAAG CAGTGGCAGG GTTTGAGCTG ACTCCAATTT

98301 TGAAAAAAAG TTCTACTTTT GGGTAAAAAA TGCTATCAAA CAGCATCAAG

98351 TGCTACAGAG AAATCTTTCA TGAAAGAAAG AGGCAATCAA TGTAGCAAAC

98401 TTCATTGTTG TCTTATTGTA AGAAACTGCC AGAGGCACCC CAACCTTCAG

98451 CAATCACTGC TGGCATCAGT CAGCAGCCAC CAACATCCTC TATCAGCAAA

98501 AAATCTTACA ATTTACTGAA AGCTCAGATG ATCAGTAGCA TTTTTTAGCA

98551 ATAAAGTATT TTTAAATTAA AGTATGCACA TTGGTTTTTT AAATATAACG

98601 CTATTGAACA TTTAATAGAC TGAAGTAGAA TATAAACATA ATATTTACAT

98651 ACACTGGTAA ACCAAAATAT TTGTGGCCTT GCTTTATGGT GATATTCACT

98701 TTATTGTGGT AGTCTATAAT GGAACCTACA GTATCTCCAA AGGTATGCTT

98751 TGTATTTACC TTTGGTACCA AATTCTAGAT ATACATCTGC ATATACCTGG

98801 GTATTTAACT TCCTGGTCTC ATGTTCCTTA AATAGTTAAT AAGAAAGAGT

98851 AATTATGAAC CATGCAGACC AATTAACAAG CCTAACTTCC AATATTTTCT

98901 TCACTCTGAA ATAAGTATTT CCAACATTGT ATTATGTCAG AAGTTCTCGG

98951 TTTTGGGGGT GCTGTATCTT AATTTTTCTG TACTCTATTT TCAACTTCAC

99001 TGACATAATA CAAGCTCTAT CTTCCTTACA AATTTATAAG GAATCAAATG

99051 AAATGAAATA TATAAAAGTT GTCCTCTTTC TCCCATCTTC AAAAAACTTC

99101 CCCCTGCATT TCATTTCCTG TTAGCCCTCT CTCCTTCAAC AGCCTGGTCT

99151 GTAGAAAGAG TCCATACATG GCCTCCCTCC ACTCCCTCAT CTTCCATTCA

99201 CTCCTTGTTC CAAGGCCTTC CCAACACCAC TGAAACTTTT TTCAATGCCC

99251 TTTTTTTAAT TTTTTTTTAA AAGCAAATTC TGCCCCCAAC TTTTCATTCT

99301 TTCAGTTGAA CCACTTTTTC CAAGACACTG CAGATGTAAA AAATACGTAG

99351 TTAAGGCCAG TGTCCAGTGG CTCATGCCTG TATTCCCAGC ACTGTGGGAG

99401 TCCAAGGCAG GAAGATCACA GGTCTGGAGT TCAAGACCAG CCTGGTCAAC

99451 ATGGTGAAAC CTCATCTCTA CTAAATATAC AAAAATAAGT CAGGCATGGT

99501 GGCAGGCACC TGTAATCCCA GCTACTCAGG AGGCTGAGGC AGGAGAATTG

99551 CTTGAACCCA GGAGGCGGAG GTTGCAGTGA GCCAAGATCG CACCATTGAC

99601 TCCAGCCTGG GGCAAAAAGC AAGACTGTGT GTGTGTTTGG AGGGGGGGAC

99651 CTGTTAATAA AAAGAAAAGA AAACAACTCA ATTTCAAAAT GGGCAAAGGA

99701 GGCCTGCCAT GGTGGCTCCT ATCTATAATC CCAGCACTTT CAGAGGCCAA

99751 GGCGGGTGGA TCACCTGAGG TCAGGAGTTC AAGACCAGCC TGGCCAACAT

99801 GGCAAAATCC CGTCTCTACT AAAAACACAA AAATTAGCCA GGCATGGTGG

99851 TGCACGCCTG TAGTCTCAGC TACTCAGGAG GCTGAGGCAG GACAATCACC

99901 TGAACCCAGA AAGTGGAGGT TGCAGTGAGC CGAGATCATG CCACTGCACT

99951 CCAGCCTAGG TGACAAGAGT AAGTCTCTGT CTCCAAAAAA AACAAACAAA

100001 AATGGGCAAA GGAGCCAAGC ATGGTGGTGC ACACATAGAG TCCCAGCTAC

100051 TGAGAGGCTG AAGTAGGAGT ATCACTTGAG CTAGAGGATC ACTTGACCCC

100101 AGGAGTTCAA GGCTGCAGTG AGCTAGAACT GTGCCACTGC AATCCAGCCT

100151 GTGTGACAGA GTAAGACTCC AAAAAAGACA AGGGCAAAGA CATGACGAGA

100201 GAGAAAAAAT AAGTATAAAA GTAAAGACAG AGAGAGAGAG ACTTCAAAGA

100251 GGAGGACAGG GCAAGACACA GTGGCCCATG CCTGTAATCC CAGCACTTTG

100301 GGAGGCTATA ATGGGAGGAT CACTTGAGCC CATGGGTTCG AGACCAGCCT

100351 AGGCAACACA GCGAGACCCC AGTATCTACA AAAACTAGCC GGGAATGGCT

100401 GGGCATGGTG GCTCACACCT GTAATCCTAG CACTTTGGGA GGCCGAGGCA

100451 GGCGGATAGC CTGAGCTCAG GAATTAGAGA CCCGCTGGGT AACAAGGAGA

100501 AACCCCATCT CTACTAAAAT ATAAAAACTT AGCCAGGGGT GGCAGCATGC

100551 ACCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TCACTTGAAC

100601 CCAGGAGGCA GAAGTTGCAC GTGAGCTGAG ATCACACCAC TACACTACTG

100651 CACTCCAGGC TGGGCAACAC AGCTACGACT CCCTCTCAAA AAAAAAATGT

100701 AAAACTAAGC TGGGCACAGT GGCTCACACC TATAATCCCA TCACTTTGGG

100751 AAGCCGAGGC AGGCAAGATC ACCTGAGGTC AGGAGTTCAA GGCCAACCTG

100801 ACCACTATGA TGAAACCCCA CCTCTACTAA AAACTCAGAA ATTAGCTGAG

100851 CATGGGGGCA TGCGACTATA ATCCCAGCTA CTCGAGAGGC AGAGACAGGA

100901 GAATCGCTTG AACCTGGGAG GAAGAGGTTG CAGTGAGCCG AGATCACACC

100951 ATTGCACTCC AGCCTGGGCA ACAAGAGTGA AACTCTGTCT CAAAAAAAAA

101001 AAAAAAAAAA AAAAAACTAG CCGGGCACAG TATTGTGCAC CTGTATTCCC

101051 AGCTACTTGG GAAGCTAAGA TGGGAGGGTC ATTTGGGCCC AGAAATTCGA

101101 AGCTGCAGTC AACTATGATT GTGCCACCGC GCTCCTGTCT AAGTAACAGA

101151 ATGAGATATT GTAATTTAAA AAATAAAAGG ATAGGTAGGA TTTACCGACT

101201 GAAAGATGAG AGTGGAAAAA GGAAGGAGGG ATAGCAAGAA TGGCGGGCAG

101251 GTAGACAGAA AGGTAAAATT CAGCCATGTT CAAAAGGGAA CAAATAAAAG

101301 CATTGAAAGG TAAGACAGAC CTAGTATATT TATGACTTGA ATCCCAAGCT

101351 AAGAAACTGG AACATAATTT AGCAGAGAGA CTCCAAAAGT TTTACAGCAA

101401 AAAGTATTAG AATCATTTAT ATACTGGGAA AAAATAGCCT CCTCATTTTA

101451 ATAATCCAGA TTGGGAAATC AGATCTAAAA CAGATGTTCA ATGGACATCC

101501 CATTTC1TTT GTAAAAGCAA CTTGAAAGGT CAGACAGCAA GTTGTGTTCT

101551 GTTTTTAATT CACAATGAAA ATCTGACTAC TCATTTATTC AACAAATATT

101601 TGAGTACCAG CTATGTGCTA GGCACTGTTC TAAACACGCC AATAACATTT

101651 ATTTAGTGGT ACTGATTCTG TACTCTAGAA CAATGGTTCT TAACTGGGGA

101701 GAGGGAGCAA TTTTTGCTGC CCAAGGGACA TCTGGCAATG TCTAAAGATA

101751 TTTTTGGTTG TCACAGGGGC AGGGGGGAGG GGAGGGGCGC GGGTGTGCTA

101801 CTATATCTAG TGGATGGAGG CCAGAAATGC TGCTTAACAT CCTACACACA

101851 GGATATACTG CCCGTGACAA GGAATTAGCT AGCCCAAAAT GTCAATAGTG

101901 CCAAAGTTGA ATAAACCTGT TCAAGAGCAA CACATTTCTA TTCCCTCTTC

101951 CATAGTAACT GTTAATAAAC ATTAGTTCCA TTTTCTACTA TTTCTGTTCT

102001 ACAATAGAGG CTTTAAAATA TCTTAAGAAA TGTAACACCA TTTTAATAAT

102051 TTGGCAAGTA GAAGTAAAGA TACCATGAAT CCTGAGATTT CACTTTCAAA

102101 AATGTATTAA GCTACATTTA TTTTACAATA AAACTTTTAG GAACAAAGTT

102151 GTCTTCTCCT TCANACACTG TTCTCAAAAA CTGTGCTAAA AGCCTTGAGT

102201 AATGTTTGAT AACTCCTTTT ATTTTGGGGT CCTTATAGCT GTTAATAACC

102251 ACATTCTGCC AGTTCTTTCC ATGTGAATGC CTCACATTTC AATGGATCTT

102301 TTTATATACC AATGTATTAT CTTGAAACAT TTTACTAACT GGTTTTTCTG

102351 AAGCTCAATG TCCTTGTCTC CTTCCCTCCC AAGCTATCCC TACCCATTAA

102401 TACTGTACTT TTCACCTGCT CAAAAGTCCA TATGGTTGCC TGTAACATAC

102451 CAAATAAGAA CCTAATTCCT AAAGCTTGAC ATTCAAATCC TTTTTTCAAC

102501 TAGCTACAAT CCACTTTTCC AACTCTTTTT TCCACTGCTC TCCCTTAGGA

102551 GTAGCCTTTT TTAGCAAAAT GACTTATTCT GAGATACACA AATAACCTTT

102601 CCAGATCAGA GACATCAAAA GCCATTCAGG CTTCACTGAG ACAAAAGATA

102651 TGCACACAAC TCAGAATAAC AGTAAGGAAT CAACTTATAG GGAAACCAGA

102701 TGTAGCCATG CTCTTTAAAT ATTGAGAGAT AACCCCGTTG GCTCATGCCA

102751 CTGTCCTTAT ATATAACAGC CCGTATTTGC CTTTCTACTT TTCTGATCTC

102801 CTTATACTTC AAATGTACAA TCTTTTCAAA AACCCAAACA CAGAGTCACC

102851 TCAGTCACCA CTNNTTGCCC TTCTCCTACC GCACCCAATG CCTGNGGCTT

102901 TCAGGTCATT TATTTTGCAN TAAACTTGTT ATCTCAATTT TACTGGTTCT

102951 CTTTTAGATT CAGACAGCTG AGATTATGAT AGATTCATTA GTAAGCTGAA

103001 TGGGGAAGGA AAGGATATTT ACATTCCCAG GCCAATTTTC AATGCTTTTT

103051 GGAAGATTCT GTTAAATTCA TAATTTCCAG AACTGGCAAG GAATAGGTAA

103101 ATATATACAC TCATATATAA CTGGTAAGAC TATAAATTGG TATAATTATC

103151 CTACAGTGAT ATCTGCCAAC ATTGAAAGTC TTTAAAATCT GTATACCCTT

103201 TGGCCTAGGA ATTCAACTTG AAAATTTATC ATGAGTAAAT TATAAAATGT

103251 ACAAAGGTTT AACTATAAAG ACACTCATCT CTGCATTGTT TCTAACTCTC

103301 AAAGATTGAG GGGGAGGGGA AAATCCCTTG TCCAATAAAA AAAGACTATT

103351 CCATGAATCA TTTATTTAAG TAATGTAATA CTTTGCAACT ACTAAAATCC

103401 TATAGTATCA TGGTTATTGA CATGTAACTC TTTTAATGGC TTTCTTTCCT

103451 AAGCTAAAAA AATACAAACA TGATTCCACA TAATGTATTT CAAAAATTGG

103501 TATACATTTT TCTACTTTTC TATATTTTCT ACACATCTAT ATATAATTTG

103551 TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTATGCA TGCATGTAAA

103601 TAAAATATAC CTCTAAGTCT TTGTAACCTT AAGATGGTGG AGCAAAATAT

103651 TTTTATTTTC TGTTGTTGAT TATTTAAAAT TTAGCTATAT TAAATCTTTT

103701 CTGATTTAGT AAACATACAT AAGGCCTATT TATAGTTGAA TGGCAGTCTT

103751 ACAAAACCTA AGCAACCTTG GTTTACTCTA TCTGTGGGAA AAGCATTTTT

103801 AGTAGAATGC TTGCGCATCT TCCTACATTC CTGAATCAAC CAGTATTTAT

103851 CATCAACTAT GTTGGTGACT CTCACTTTGA CATAGGCTGA ACCAGAAATC

103901 CTAGGAAAAA CTGATGACAG AAAGCTAAGG GGAAGGATAG GAAACCGGGA

103951 AACCCCGGGA AAGGAGGGAT TATATTACAC ATGTTATGGG AACTAGTTTG

104001 TATGTGCGGG GCACAGAGCA TACACTTAGA TAAGAAGGGG GTCATAAAAC

104051 CAGAAAGGCA ATAAATAGAA TGTTATGAGC ATGAACTCTA GACGCAAACT

104101 GTTCAGGTTC AATCTCACCT CTGCTTCTTA CTACATTTAT TACCTTAAGC

104151 AAGTCACTTA ACTTCTCCCT GCCGTTTCTG CCACATCTGT ATAATGGGGA

104201 TAACAGACCC TACCTTAGAG GGCTGTCACA CTAATGAATT CTGAGAATAG

104251 TCCCTGGTAC TACAGTTAAG TGCTCATTAG TTGTCCACAC TCATCATCTT

104301 CATTACTCCC ATTACTATGA TGTGAAGAGT TGTGCTGTTA GGACGGGAGA

104351 AGCAACTTTT CAACACCAAT CACTTTTTTA GACGGCCTCC TTTCTAGCCT

104401 TGTTAGTTGC CCAAATTCTG AAAAAAACAA GAACTAAGAC TCTAGAAGGA

104451 GATCCGAGAG GCAGACGTGT GTCTCTGTGT GTGTTTGTGT GTGTGTGTAG

104501 GTGCGTGTGC ATGTAGACGA AGGAGGAATC AGGAGTAATG CCAAGAATGA

104551 GAATCAAATC TGTATAAGCA GTTCAGAAAA GGGGCATCAT GAGTCGCTCT

104601 TCTCAGTGCT GCCCCAAGGG TTCCACAGTT TGCTCCTTCC ATCATTCACT

104651 TGGATAAAAC CTTTCAATGT CTCTCCATGG CCTTCAGAGT TAAATCAAAA

104701 CTATTCCTTG GAATGACTTA AAACCCATAC TATCTCTAAA GCCTCATCTC

104751 TTGGCTCTCT CGCACCAAGC TCACTGAGCT TCCAGCCCTA CCAAATTTCT

104801 TCAGTAACAA CCTCTCACAT CTCAGAGCCT TTGCATATGC TGCTCCCTCT

104851 GCCTGAAAAG TAACCTCTAC CTCCTCCAAT AGCAAACTGC TACTCAACCT

104901 TCAAAACACA GCTCAAGGAT AACTCCAGAG CTCTTTCGTG ATTTCAAGCT

104951 AAATGACTCT GCTATATTAT CCCCCATGTG CATAACACCA CCACTACCAC

105001 CACCACCATC ACCACTAAAA CCACGACCAC CACTACTCAC GCACTACCAC

105051 CACCACCACC ACCAACACCA ACACCACCAC CATGACCACT ACCACTACCA

105101 CCACCACCAC CATCACCACT ACTCACCACC ACCACTACCA CCACCAACAC

105151 CAACACCAAC ACCACCACCA TCACCACTAC CACTACCACC ACCACCAACA

105201 CCATCACCAC TACGACCACG ACCACCACCA CTACCACCAC CACCACCACC

105251 ACTACCACCA CCACCACCAT CACCACTAAA ACCACGACCA CCACCACCAC

105301 CATCACCACC ATCACCACCA CCACCACCAC CATCACGCAC CACCACCACC

105351 ACCACCATCA CCACCACCAC CACCATCACC ACCACTATCA CCACCACCAC

105401 AATGACCAGC ACCACCATTA GCACCAGCAT CACCACGAG. ........GG

105451 TTCAAGCAAT TCTCTGCCTC AGCCTCCCAA GTAGCTGGGA TTACAGGTGC

105501 CTGCCACCAT GCCTGGCTAA TTTTTGTAGT TTTAGTAGAG ATGGGGTTTC

105551 ACCATCTTAG CCAGGCTGGT CTTGAACTCC TGACCTCGTG ATCCATCTGC

105601 CTCAGCCTCC CAAAGTGCTG GGATTACAGG CGTGAGCCGC TGTTCCTGGC

105651 AGAGATTCTA AGTTTTTTGA GAATAGTGAC TGTGTTTCTT GGGTCATGGC

105701 TCTATCTTAT ACATTTGGCA CAGTGTGTGT GTGTAGCAGG TGTTTAATAT

105751 TTGTTAAACA CAAGTGGTCC TTAATATCAA ACAGCATGGG ATTTAAGACA

105801 TGAACTTAGG TTTGAGTCTC AGCACTTTCA CTTCTTAGTT GTATGACCTT

105851 GGTCATTTAA TCTCTTTGAT CTTGAATTTC CTTATCCGAA AAATAGGGGA

105901 CATACTAATT AACATCTATT GTGATGGGTT GTAATGAGAA TTAAATGACA

105951 ATGTGTACAA AATACCTAAC TTGATTGGAT TTGTGGTACG CAGTAGCTAT

106001 AATGACCATT TTAACCCCAA TATGAGAAGG ATTCACTCGT CACACTGTTG

106051 TATACTTCGT AGCTATTACT TCTTTAATCC CCAAGGACTT GTTTAACAAA

106101 GTGTTCTTCA GTTTCTACTT CCCAATTCCT TTGTGGAACT GGAAAAATTT

106151 AAAATATCTT AACATAATAT TTTATTTCAA ATGACAAACA GTAAGGTAAA

106201 ATGTGGTTTT TCTTGGCAAC ATATGGTAGA ATGATGTCTA GAATATTTAG

106251 TTATGCATTT AATACTTTTT TTCTTTACCA TTTTTTAAAA AAATATTTTA

106301 TTTTAGATTC GGGGGTACAC ATGCAGGTTC GTTACATGGC TAGATTATGT

106351 AATGCCGAGG TTTGGCCTGC TAGCACAGCC ATCATCCAAA GTGATCCTAG

106401 TACCCAATAG GTAGTTTTCA ACCTGTGTAC CTCCTCTTCT ACCTTCTCTT

106451 TTGGAATCTC TAGTCTATTA CTTCCATCTT TATGTTCACA TGTACTCATT

106501 GTTTAGCTCC CACTTAGAAA TGAGACCATG TGGTATTTGA TTTTCTGGTT

106551 CTGAGTTACT TCTTTTAGGA CAAAGGATGA AAAAGAATGT AGCCTCCAGC

106601 TCCATCCATG TTGCTGCGAA GGACATGATT CCATTCTTTT TTATGGCTGA

106651 rTATATTTTT ACCTTTTTTG TGAGGGGGAG AGGATTTAAA TATGGACCAG

106701 CATAATGAAG AAAATATCTG TAATCCCACT ATTCACATAA CCCTTGCTAG

106751 TTTAAAACAA GTTCATGTAG GCTGAGCATG GTGGCTCACA CCTATAATCC

106801 CAGCACTTTG GGAGTCCAAG GCTGGAGGAT CACTTGAGTT TAAGAGTTTA

106851 AGACCAGCTT GAGTAACATA GTGAAACACC ATGTCTACAA AAAATAAAAA

106901 TTAGCCAGGT ATGGTGGTGT ATGCCTGTAG TCCCAGCTAC TTGGGAGGAT

106951 TGCTTGAGGC CAAGAGTTCG AGGCTGCAGT AAGCTGTGAT TGTGCCACTG

107001 CACTCCACCA GGTGTTTAAA AAAAAAAGTA AATAATTACA AAATTTAAAT

107051 AGTGTAAACT AGAGGCCTCT CCTATTAGTT TGCTAGAGTT ACCATAACAA

107101 AATACCACAA ACTGAGTGAC ATAAGTGACA CTATTTTTTT TTTTTTGAGA

107151 TGCAGTCTCA CTCTGTCACC AGGCTGCACG ATCTCGGCTC ACTGCAGCCT

107201 CGGCCTCCCA GGTTCAAGTG ATTCTCCTAC CTCGGCCTCC CGAGTAGCTG

107251 GGACTTCCAG CCTCCAGAAT TGAGAAATTT AATTTCTTTT AATTTTAAAA

107301 AATTAAGAGT GACACTTGGC CGGGCGCAGT GGCTCATGCC TATAATCCCA

107351 GCACTTTGGG AGGCTGAGGC GGGCAGATCA CGAGGCCAGG AGATCGAGAC

107401 TATCCTGGCT AACACAGTGA AACCCCGTCT CTACTAAAAA TACAAAAAGT

107451 TGGTCGGGCG TGGTGGCTCA TGCCTGTAAT CCCAGCACTT TGGGAGTCCG

107501 AGGTAGGCGG ATAACCTGAG GTTGGGAGTT TCAGACCAGT ATGACCAACA

107551 CGGAGAAACC CTGTGTCTAC TAAAAATACA AAATTAGCTG TGCATGGTGG

107601 TGCATGCTTG TAA

<210>2

<211>11162bp

<212>DNA

<213>

<400>gene vector sequenence

1 GGGCGAATTG GGCCCGACGT CGCATGCTCC TCTAGACTCG AGGAATTCTA

51 CCGGGTAGGG GAGGCGCTTT TCCCAAGGCA GTCTGGAGCA TGCGCTTAAG

101 CAGCCCCGCT GGGCACTTGG CGCTACACAA GTGGCCTCTG GCCTCGCACA

151 CATTCCACAT CCACCGGTAG GCGCCAACCG GCTCCGTTCT TTGGTGGCCC

201 CTTCGCGCCA CCTTCTACTC CTCCCCTAGT CAGGAAGTTC CCCCCCGCCC

251 CGCAGCTCGC GTCGTGCAGG ACGTGACAAA TGGAAGTAGC ACGTCTCACT

301 AGTCTCGTGC AGATGGACAG CACCGCTGAG CAATGGAAGC GGGTAGGCCT

351 TTGGGGCAGC GGCCAATAGC AGCTTTGCTC CTTCGCTTTC TGGGCTCAGA

401 GGCTGGGAAG GGGTGGGTCC GGGGGCGGGC TCAGGGGCGG GCTCAGGGGC

451 GGGGCGGGCG CCCGAAGGTC CTCCGGAGGC CCGGCATTCT GACGCTTCAA

501 AAGCGCACGT CTGCCGCGCT GTTCTCCTCT TCCTCATCTC CGGCCTTTCG

551 ACCTGCAGCG ACCCGCTTAA CAGCGTCAAC AGCGTGCCGC AGATCTTGGT

601 GGCGTGAAAC TCCCGCACCT CTTCGGCAAG CGCCTTGTAG AAGCGCGTAT

651 GGCTTCGTAC CCCTGCCATC AACACGCGTC TGCGTTCGAC CAGGCTGCGC

701 GTTCTCGCGG CCATAGCAAC CGACGTACGG CGTTGCGCCC TCGCCGGCAG

751 CAAGAAGCCA CGGAAGTCCG CCTGGAGCAG AAAATGCCCA CGCTACTGCG

801 GGTTTATATA GACGGTCCTC ACGGGATGGG GAAAACCACC ACCACGCAAC

851 TGCTGGTGGC CCTGGGTTCG CGCGACGATA TCGTCTACGT ACCCGAGCCC

901 GATGACTTAC TGGCAGGTGC TGGGGGCTTC CGAGACAATC GCGAACATCT

951 ACACCACACA ACACCGCCTC GACCAGGGTG AGATATCGGC CGGGGACGCG

1001 GCGGTGGTAA TGACAAGCGC CCAGATAACA ATGGGCATGC CTTATGCCGT

1051 GACCGACGCC GTTCTGGCTC CTCATATCGG GGGGGAGGCT GGGAGCTCAC

1101 ATGCCCCGCC CCCGGCCCTC ACCCTCATCT TCGACCGCCA TCCCATCGCC

1151 GCCCTCCTGT GCTACCCGGC CGCGCGATAC CTTATGGGCA GCATGACCCC

1201 CCAGGCCGTG CTGGCGTTCG TGGCCCTCAT CCCGCCGACC TTGCCCGGCA

1251 CAAACATCGT GTTGGGGGCC CTTCCGGAGG ACAGACACAT CGACCGCCTG

1301 GCCAAACGCC AGCGCCCCGG CGAGCGGCTT GACCTGGCTA TGCTGGCCGC

1351 GATTCGCCGC GTTTACGGGC TGCTTGCCAA TACGGTGCGG TATCTGCAGG

1401 GCGGCGGGTC GTGGCGGGAG GATTGGGGAC AGCTTTCGGG GACGGCCGTG

1451 CCCGCCCCAG GGTGCCGAGC CCCAGAGCAA CGCGGGCCCA CGACCCCATA

1501 TCGGGGACAC GTTATTTACC CTGTTTCGGG CCCCCGAGTT GCTGGCCCCC

1551 AACGGCGACC TGTACAACGT GTTTGCCTGG GCCTTGGACG TCTTGGCCAA

1601 ACGCCTCCGT CCCATGCACG TCTTTATCCT GGATTACGAC CAATCGCCCG

1651 CCGGCTGCCG GGACGCCCTG CTGCAACTTA CCTCCGGGAT GGTCCAGACC

1701 CACGTCACCA CCCCCGGCTC CATACCGACG ATCTGCGACC TGGCGCGCAC

1751 GTTTGCCCGG GAGATGGGGG AGGCTAACTG AAACACGGAA GGAGACAATA

1801 CCGGAAGGAA CCCGCGCTAT GACGGCAATA AAAAGACAGA ATAAAACGCA

1851 CGGGTGTTGG GTCGTTTGTT CATAAACGCG GGGTTCGGTC CCAGGGCTGG

1901 CACTCTGTCG ATACCCCACC GAGACCCCAT TGGGGCCAAT ACGCCCGCGT

1951 TTCTTCCTTT TCCCCACCCC ACCCCCCAAG TTCGGGTGAA GGCCCAGGGC

2001 TCGCAGCCAA CGTCGGGGCG GCAAGCCCTG CCATAGCCAC GGGCCCCGTG

2051 GGTTAGGGAC GGGGTCCCCC ATGGGGAATG GTTTATGGTT CGTGGGGGTT

2101 ATTATTTTGG GCGTTGCGTG GGGTCAGGTC CACGACTGGA CTGAGCAGAC

2151 AGACCCATGG TTTTTGGATG GCCTGGGCAT GGACCGCATG TACTGGCGCG

2201 ACACGAACAC CGGGCGTCTG TGGCTGCCAA ACACCCCCGA CCCCCAAAAA

2251 CCACCGCGCG GATTTCTGGC GCCGCCGGAC GAACTAAACC TGACTACGGC

2301 ATCTCTGCCC CTTCTTCGCT GGTACGAGGA GCGCTTTTGT TTTGTATTGG

2351 TCACCACGGC CGAGTTTCCG CGGGACCCCG GCCAGGACCT GCAGAAATTG

2401 ATGATCTATT AAACAATAAA GATGTCCACT AAAATGGAAG TTTTTCCTGT

2451 CATACTTTGT TAAGAAGGGT GAGAACAGAG TACCTACATT TTGAATGGAA

2501 GGATTGGAGC TACGGGGGTG GGGGTGGGGT GGGATTAGAT AAATGCCTGC

2551 TCTTTACTGA AGGCTCTTTA CTATTGCTTT ATGATAATGT TTCATAGTTG

2601 GATATCATAA TTTAAACAAG CAAAACCAAA TTAAGGGCCA GCTCATTCCT

2651 CCCACTCATG ATCTATAGAT CTATAGATCT CTCGTGGGAT CATTGTTTTT

2701 CTCTTGATTC CCACTTTGTG GTTCTAAGTA CTGTGGTTTC CAAATGTGTC

2751 AGTTTCATAG CCTGAAGAAC GAGATCAGCA GCCTCTGTTC CACATACACT

2801 TCATTCTCAG TATTGTTTTG CCAAGTTCTA ATTCCATCAG AAGCTCCTTA

2851 ATTTTATACC ACTGACTTAT TTTGAAGGCT GCTATAAGAA ACAGCCCTAT

2901 GAAACTGGTA TTTTCCTACT GCAAGGTGGC TACTTTAAGA CAATTTTTCA

2951 TTGCATTCTA TCAAGGGATG TCTTATTATT ATATCATTAT ATCAAGTGAT

3001 GTTATAAATA GTAAGAATCA GATTAAGGGC TCATATGTCC TTCTTTGTAT

3051 TGACTGTTGA AAAGGTATGG GGCCAAATTT GTAGTTTGTC TGGAATTACA

3101 TATTTTTGGG GGTCTCTATT ATCTTCATAC TTATCCTATC TAAATTTTCC

3151 ATTGCCAAAT TTCCTTACTT ATTTTTAGTT TTATCCTATT GCTCATGTAT

3201 TTTTATGTCT CCATAAGTCT ATTTTGGAAA AAGGCAGAGT ACTCATAATT

3251 TTAGTATATC TTTTAGCTTT ATGTTGCCAT AAACCTTTCA TTATATACAT

3301 GATCAACAAC AGCAAATTAT CTCACTTCAG TATTTAGTTT ATTATTTTAC

3351 AAACTGATTT ATGATTGCTA ACATGTAACT GAAGGTATAC ACTATTAGAA

3401 CACAGTTTTC AGTAGAAAGT AGCACTGCCA TTGAGTAAAA AAATGTTCTA

3451 ACATTAGAGC AACATTCTTA TACAAGTTTG CATGTTGTTT ACTGAGGTCT

3501 AAAGCATGAC TACACAAAAG GCTGAATAAA ATTCAGATTC TTACATACAC

3551 ATAAAATTGT TTTATTGAGA TGACAAAGTA TATTTATTAT GCCACCCAGA

3601 ATATAATCCA CTCTGATAAC TGCCAGTGTA TGCACTTGCT GAAGTAACTC

3651 AGTACATAAA TGGTAGCCAC AACAGTTGCT GTGCATGAAA GTTCTTCTCT

3701 TCCAGATTGA AGAGTGTACA ATCTAAAGCA TTTTAAAACT TTAAATCCCT

3751 TATTAGCTTA AATATAATTT AAAATTTTAG TTTGCCGTAC CTATAATTTG

3801 TCTGTACACT AGGTTACTAA GGGTGATATG ATTACATATG TGGATACAAA

3851 ATAATTTTAA TGGAAAATGA AATTAGGGTA CTCAACAAAG ATAAAGGGTA

3901 ATGATCATGT ACACTAACCG TATTTGAGAT TAGTTTAAGC CTGGGGTAGC

3951 TATACTTATG TTTCACAGAC CTTGAGAAGA TAGGGAAAAA AAGCTTTTAT

4001 CAACATTGCT AAGGAACAGG TAAAAGCTAA CATTAGGTAA CTAAGAGGTG

4051 ACATAAAAAA GACTGAATAA AATATCATGG AGGTTTCATA ATAAGATTGG

4101 AAATTCCATA GACTAGGAGA GAAAAGATCC CAAAATATAC ATGCTCATTG

4151 GGAAAACAGC TAGTAAGAAC AAGGAGAGAT CTCTATTTAA TGATACAATA

4201 GTAGAGTTAT AATTTCCTGT ATATTGTAAA TTTCAAGCAT TTAAACATTT

4251 TCATTGAATT ATAAAATATT ATTTGTAAAA GAAAG AAAA CAGCACAACT

4301 GCAGATTACA GATGACTAAG ATAGATGAAT CATGAAAAGG TGCTAGATTG

4351 TGAGCGGATA ACAATTTCAC ACAGGAAACA GCTATGACCA TGATTACGCC

4401 AAGCTCTCGA CGGGATCGCG GCCGCGATCC AGACATGATA AGATACATTG

4451 ATGAGTTTGG ACAAACCACA ACTAGAATGC AGTGAAAAAA ATGCTTTATT

4501 TGTGAAATTT GTGATGCTAT TGCTTTATTT GTAACCATTA TAAGCTGCAA

4551 TAAACAAGTT GGGGTGGGCG AAGAACTCCA GCATGAGATC CCCGCGCTGG

4601 AGGATCATCC AGCCGGCGTC CCGGAAAACG ATTCCGAAGC CCAACCTTTC

4651 ATAGAAGGCG GCGGTGGAAT CGAAATCTCG TGATGGCAGG TTGGGCGTCG

4701 CTTGGTCGGT CATTTCGAAC CCCAGAGTCC CGCTCAGAAG AACTCGTCAA

4751 GAAGGCGATA GAAGGCGATG CGCTGCGAAT CGGGAGCGGC GATACCGTAA

4801 AGCACGAGGA AGCGGTCAGC CCATTCGCCG CCAAGCTCTT CAGCAATATC

4851 ACGGGTAGCC AACACTATGT CCTGATAGCG GTCCGCCACA CCCAGCCGGC

4901 CACAGTCGAT GAATCCAGAA AAGCGGCCAT TTTCCACCAT GATATTCGGC

4951 AAGCAGGCAT CGCCATGGGT CACGACGAGA TCCTCGCCGT CGGGCATGCT

5001 CGCCTTGAGC CTGGCGAACA GTTCGGCTGG CGCGAGCCCC TGATGCTCTT

5051 CGTCCAGATC ATCCTGATCG ACAAGACCGG CTTCCATCCG AGTACGTGCT

5101 CGCTCGATGC GATGTTTCGC TTGGTGGTCG AATGGGCAGG TAGCCGGATC

5151 AAGCGTATGC AGCCGCCGCA TTGCATCAGC CATGATGGAT ACTTTCTCGG

5201 CAGGAGCAAG GTGAGATGAC AGGAGATCCT GCCCCGGCAC TTCGCCCAAT

5251 AGCAGCCAGT CCCTTCCCGC TTCAGTGACA ACGTCGAGCA CAGCTGCGCA

5301 AGGAACGCCC GTCGTGGCCA GCCACGATAG CCGCGCTGCC TCGTCTTGCA

5351 GTTCATTCAG GGCACCGGAC AGGTCGGTCT TGACAAAAAG AACCGGGCGC

5401 CCCTGCGCTG ACAGCCGGAA CACGGCGGCA TCAGAGCAGC CGATTGTCTG

5451 TTGTGCCCAG TCATAGCCGA ATAGCCTCTC CACCCAAGCG GCCGGAGAAC

5501 CTGCGTGCAA TCCATCTTGT TCAACCATGG TGGATCGATC CAAGCTCCCA

5551 ACACAACTAT GTCAGAAGCA AATGTGAGGA GCAACTGATC CTACCTCACC

5601 TTATATGCTC TGCCCTGGCT CCTGCCCTCT CTATCCTGTG TGAGCAGATT

5651 GGCCCTTACC AAGGTGTGGC TCTACGGAAT CAGGCTTCGG TGATGACAAG

5701 CATATTTCTC CCTAGAATGC TGTGCCACTC ACTGGCTTAG GAGTCTCAGC

5751 TCTGGGTACT CCCTCTGAAT AATGTTTGTC CTTATCTGTG CAGAGAACAC

5801 TGTCTCTAAA GCATCCTTTT TGGCAACGCA TTTGCTCAAT CAACTACTGA

5851 ATTGGTGTTA AAATTAATTT TCCTTTTTTT CTCATTATGC AAATAAGAAA

5901 TTGAGAAGCA AAGCTAGCAG AGATTTCTAT CACACCTATC AGGGATACAC

5951 AATTTCCAAG AATTTCAGAA GTGTTTGGTG TTCCTATTAA CATAAATCCG

6001 GAAATAACAC CTGAGTGAAC TGTCTTCTAA TTCTTCAACT GGATGGCTTT

6051 TTAGTGTAAA AGATGTTGAA TACTGATTGA CTTTTTAATA ATTTTATAGT

6101 ATATGTCAGA AATATTGCAC AGTCCCTATT TACATCATTC TACAGTGGTT

6151 TTTAAAATGT TTTAAGAATA AAAAACATGA AAACTTTATT TGATTTTTCT

6201 GAGGAAATAA CTTTTTGGAT TTAATTTCAA TGAAACCGTT GATAACATTT

6251 CCCTCCCCAA CAATCTCTGG CAACGATCCC TCAGATTTTA ATGATTATGT

6301 ATTATTACCT TTTAATACAA GTAGAATAAC ACTCAGGGAA TTTACAACAT

6351 TTGTTATTTT CAGTAAATAC ATTGGTTGAA GTTTAAAAGT CTATCCGTAG

6401 TAAACTTACA TCTTTCAGGA GCTTGGTCAA TGTGTTCTGG ACAAAGCAGG

6451 AAGATGTGAC TGAAATCCTG AAAGGAGCCG GCTCCTGCAG CACAAGGATA

6501 ATGATACATC TGGGTACATT TCTCTTCACA GCATTTGATA GTGGCTCCAA

6551 AGTGCTTACA AAATGCACAT TGCTGAAAGG GGTAAAGGAG AGAAATCTCT

6601 TTATAAAACC TTGAAAAGGA ATATTTAAAT ATAAGCTGGG AAGGTATAAA

6651 AAACTCTCTG TAACATCACA AGTAAACAAA TTGAACCTGC AAAATATTAA

6701 ACAAAGGATT CATTAAAAAT AATAAAATCT ACATTACTCA ATTTAGTGCT

6751 TTGTGTGCTA CCAACTCATC CTTCCATTCA AATTAGAAAG TTAGAATTTC

6801 ATTCCTTATA TTTTCAAAAA TAAATTGTGA AGCATTTTAG AAACAAAACC

6851 TAAAATTTTT TTTTAAAAGC AAATAGTAAT ATGGTTAAAG GGGCAGGTTT

6901 CTATATTGAG GATTATTATA AAGTTTTTAA ATCCTACCAA AACTAGTAAT

6951 AGGAACATAT ATTATTTATG AGACATATTA CTATTTTTTA CCCTGCCTAA

7001 AAATAAATAC AAATAAATTC ATCAATTATA AGTTAACAGG GACACAAATG

7051 GTTAAAGACT CACACACAAA AAAAACAAAA CTACATACTT CAATGTAGCA

7101 ATCAACTTCA AATTTCTTAA CAAAAGATGG AAATGTTGGG GAAAAAATTA

7151 GTCATCTGGT ATCTTTCCCA TTTCAACCTG CCTCCATTAT CTTGCAAGTG

7201 GTAAAATGCA CAGAAATAAG CCTCAAACAA GAGGGGCAGT CTAGGGCAAG

7251 TGAACACATA AGTCGGAAGA AATTATGTAA AATGTTGCAT TTACTTATTC

7301 AGTTTTCCCT TAGAATGATT CACAAACTCT TCCTCATTCT CCCAAGTCCA

7351 TTTTGAGTAT CATTTTCTTT GAAGAGAGTC TGATGGGCCC TGTACTATAC

7401 AGTATGAAAT CTCTCTGTGG GAAATGACTA TCTAACATAA ATTTTTGTTT

7451 ACACCGTTAC ATGGTACCTA CTTGCTTATG CCATTACATG ATCAGTTTAC

7501 CTTTTTCTCA ACCTAATCCA AGATCCTTCA ATTGAGGCAC TATACTATCT

7551 TTGTATCCAA AGCACCAAAA ATGCTGCTTC AAACAGGCCC TAATAGATAG

7601 GTGTTCCTAT ACATATACCA AAAAGACTTA ACTTTTGGTG ATCTTGTTTG

7651 TGAGTGTGGC TCATAAACAG CTTAGTTGAG ATAACTGGAG CCTCATGTAG

7701 CAGAGACAGT TGGACCCTGC TAACATTACT GTGGATATCT TCACATGTTA

7751 CTACATTGAC TTTATATTCT GCTAATTAAC CAGGGACTAC AGTAGTTAAA

7801 ATTATAATTG TTTTCAATGT TTTATGTGTA AATCTGTATC TCACATACTA

7851 TCAAACTCTT CCTCACTGTC ATCAGTCTAC TGCATTGAAT CCAACATAAC

7901 AAAGCTAAAT GACTCCTGAG GGCTGAATCA GAAAGAAGAA AAGAAAGAGA

7951 TACAAAACTT TAGTCGGCCC GGTGGCTCAC ACCTGTAATC CCAGCACTTT

8001 GGAAGGCCAA GGCGGGCGGA TCACGAGGTC AGGAGATCGA GACCATCCTG

8051 GCTGATACAG TGAAACTCCA TCTCTACTGA AAATACAAAA AATTAGCTGG

8101 ACGTGGTGGT GGGCACCTGT AGTCCCAGCT ACTCAGGAGG CTGAAGCAGG

8151 AGAAGCTTCT AAATAACTCA TAAACACTAA TTACTGTTGT GACACTTTAA

8201 TTTTATACAA TATTTATAAG TATACAGAAT AACATTTCAG TGCTATTTTG

8251 GCACTCAAGG GTATTAATGC ATAGCTTGAG TATTCTATAG TGTCACCTAA

8301 ATAGCTTGGC GTAATCATGG TCATAGCTGT TTCCTGTGTG AAATTGTTAT

8351 CCGCTCACAA TTCCACACAA CATACGAGCC GGAAGCATAA AGTGTAAAGC

8401 CTGGGGTGCC TAATGAGTGA GCTAACTCAC ATTAATTGCG TTGCGCTCAC

8451 TGCCCGCTTT CCAGTCGGGA AACCTGTCGT GCCAGCTGCA TTAATGAATC

8501 GGCCAACGCG CGGGGAGAGG CGGTTTGCGT ATTGGGCGCT CTTCCGCTTC

8551 CTCGCTCACT GACTCGCTGC GCTCGGTCGT TCGGCTGCGG CGAGCGGTAT

8601 CAGCTCACTC AAAGGCGGTA ATACGGTTAT CCACAGAATC AGGGGATAAC

8651 GCAGGAAAGA ACATGTGAGC AAAAGGCCAG CAAAAGGCCA GGAACCGTAA

8701 AAAGGCCGCG TTGCTGGCGT TTTTCGATAG GCTCCGCCCC CCTGACGAGC

8751 ATCACAAAAA TCGACGCTCA AGTCAGAGGT GGCGAAACCC GACAGGACTA

8801 TAAAGATACC AGGCGTTTCC CCCTGGAAGC TCCCTCGTGC GCTCTCCTGT

8851 TCCGACCCTG CCGCTTACCG GATACCTGTC CGCCTTTCTC CCTTCGGGAA

8901 GCGTGGCGCT TTCTCATAGC TCACGCTGTA GGTATCTCAG TTCGGTGTAG

8951 GTCGTTCGCT CCAAGCTGGG CTGTGTGCAC GAACCCCCCG TTCAGCCCGA

9001 CCGCTGCGCC TTATCCGGTA ACTATCGTCT TGAGTCCAAC CCGGTAAGAC

9051 ACGACTTATC GCCACTGGCA GCAGCCACTG GTAACAGGAT TAGCAGAGCG

9101 AGGTATGTAG GCGGTGCTAC AGAGTTCTTG AAGTGGTGGC CTAACTACGG

9151 CTACACTAGA AGGACAGTAT TTGGTATCTG CGCTCTGCTG AAGCCAGTTA

9201 CCTTCGGAAA AAGAGTTGGT AGCTCTTGAT CCGGCAAACA AACCACCGCT

9251 GGTAGCGGTG GTTTTTTTGT TTGCAAGCAG CAGATTACGC GCAGAAAAAA

9301 AGGATCTCAA GAAGATCCTT TGATCTTTTC TACGGGGTCT GACGCTCAGT

9351 GGAACGAAAA CTCACGTTAA GGGATTTTGG TCATGAGATT ATCAAAAAGG

9401 ATCTTCACCT AGATCCTTTT AAATTAAAAA TGAAGTTTTA AATCAATCTA

9451 AAGTATATAT GAGTAAACTT GGTCTGACAG TTACCAATGC TTAATCAGTG

9501 AGGCACCTAT CTCAGCGATC TGTCTATTTC GTTCATCCAT AGTTGCCTGA

9551 CTCCCCGTCG TGTAGATAAC TACGATACGG GAGGGCTTAC CATCTGGCCC

9601 CAGTGCTGCA ATGATACCGC GAGACCCACG CTCACCGGCT CCAGATTTAT

9651 CAGCAATAAA CCAGCCAGCC GGAAGGGCCG AGCGCAGAAG TGGTCCTGCA

9701 ACTTTATCCG CCTCCATCCA GTCTATTAAT TGTTGCCGGG AAGCTAGAGT

9751 AAGTAGTTCG CCAGTTAATA GTTTGCGCAA CGTTGTTGGC ATTGCTACAG

9801 GCATCGTGGT GTCACGCTCG TCGTTTGGTA TGGCTTCATT CAGCTCCGGT

9851 TCCCAACGAT CAAGGCGAGT TACATGATCC CCCATGTTGT GCAAAAAAGC

9901 GGTTAGCTCC TTCGGTCCTC CGATCGTTGT CAGAAGTAAG TTGGCCGCAG

9951 TGTTATCACT CATGGTTATG GCAGCACTGC ATAATTCTCT TACTGTCATG

10001 CCATCCGTAA GATGCTTTTC TGTGACTGGT GAGTACTCAA CCAAGTCATT

10051 CTGAGAATAC CGCGCCCGGC GACCGAGTTG CTCTTGCCCG GCGTCAATAC

10101 GGGATAATAG TGTATGACAT AGCAGAACTT TAAAAGTGCT CATCATTGGA

10151 AAACGTTCTT CGGGGCGAAA ACTCTCAAGG ATCTTACCGC TGTTGAGATC

10201 CAGTTCGATG TAACCCACTC GTGCACCCAA CTGATCTTCA GCATCTTTTA

10251 CTTTCACCAG CGTTTCTGGG TGAGCAAAAA CAGGAAGGCA AAATGCCGCA

10301 AAAAAGGGAA TAAGGGCGAC ACGGAAATGT TGAATACTCA TACTCTTCCT

10351 TTTTCAATAT TATTGAAGCA TTTATCAGGG TTATTGTCTC ATGAGCGGAT

10401 ACATATTTGA ATGTATTTAG AAAAATAAAC AAATAGGGGT TCCGCGCACA

10451 TTTCCCCGAA AAGTGCCACC TGTATGCGGT GTGAAATACC GCACAGATGC

10501 GTAAGGAGAA AATACCGCAT CAGGCGACGC GCCCTGTAGC GGCGCATTAA

10551 GCGCGGCGGG TGTGGTGGTT ACGCGCAGCG TGACCGCTAC ACTTGCCAGC

10601 GCCCTAGCGC CCGCTCCTTT CGCTTTCTTC CCTTCCTTTC TCGCCACGTT

10651 CGCCGGCTTT CCCCGTCAAG CTCTAAATCG GGGGCTCCCT TTAGGGTTCC

10701 GATTTAGAGC TTTACGGCAC CTCGACCGCA AAAAACTTGA TTTGGGTGAT

10751 GGTTCACGTA GTGGGCCATC GCCCTGATAG ACGGTTTTTC GCCCTTTGAC

10801 GTTGGAGTCC ACGTTCTTTA ATAGTGGACT CTTGTTCCAA ACTGGAACAA

10851 CACTCAACCC TATCTCGGTC TATTCTTTTG ATTTATAAGG GATTTTGCCG

10901 ATTTCGGCCT ATTGGTTAAA AAATGAGCTG ATTTAACAAA TATTTAACGC

10951 GAATTTTAAC AAAATATTAA CGTTTACAAT TTCCATTCGC CATTCAGGCT

11001 GCGCAACTGT TGGGAAGGGC GATCGGTGCG GGCCTCTTCG CTATTACGCC

11051 AGCTGGCGAA AGGGGGATGT GCTGCAAGGC GATTAAGTTG GGTAACGCCA

11101 GGGTTTTCCC AGTCACGACG TTGTAAAACG ACGGCCAGTG AATTGTAATA

11151 CGACTCACTA TA

Claims

1、一种载体，包括用于定点整合的基因引导序列，其特征在于所说的基因引导序列为序列表1中的75590位至79448位，或是与该序列严格杂交的序列。

2、根据权利要求1所述的载体，其特征在于含有正负筛选基因。

3、根据权利要求2所述的载体，其特征在于该载体的DNA序列如序列表2，其中利用TK做为负筛选基因，将正筛选基因Neo基因插入引导序列中的1500位，使基因引导序列分为1.5kb和2.3kb两臂，构建成基因载体，目的基因的插入位点为5910位。

4、外源基因表达方法，包括下列步骤：

(1)构建权利要求1至3之一所述的载体；

(2)将目的基因装入上述载体；

(3)将目的基因导入人体细胞的D、G组染色体短臂的核仁组织区靶位；

(4)目的基因在离体宿主细胞内表达。

5、一种基因治疗药物，含有治疗基因与载体的重组体，其特征在于载体是权利要求1至3之一所述的载体。