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CN1281358A - 噻唑烷二酮在高血糖症治疗中的应用 - Google Patents

噻唑烷二酮在高血糖症治疗中的应用 Download PDF

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Publication number
CN1281358A
CN1281358A CN98812016A CN98812016A CN1281358A CN 1281358 A CN1281358 A CN 1281358A CN 98812016 A CN98812016 A CN 98812016A CN 98812016 A CN98812016 A CN 98812016A CN 1281358 A CN1281358 A CN 1281358A
Authority
CN
China
Prior art keywords
hyperglycemia
plasma glucose
compound
insulin sensitizer
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98812016A
Other languages
English (en)
Chinese (zh)
Inventor
R·E·白金汉
S·A·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1281358A publication Critical patent/CN1281358A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN98812016A 1997-10-13 1998-10-12 噻唑烷二酮在高血糖症治疗中的应用 Pending CN1281358A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9721692.3A GB9721692D0 (en) 1997-10-13 1997-10-13 Novel treatment
GB9721692.3 1997-10-13

Publications (1)

Publication Number Publication Date
CN1281358A true CN1281358A (zh) 2001-01-24

Family

ID=10820481

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98812016A Pending CN1281358A (zh) 1997-10-13 1998-10-12 噻唑烷二酮在高血糖症治疗中的应用

Country Status (24)

Country Link
EP (1) EP1023057A1 (pt)
JP (1) JP2001519383A (pt)
KR (1) KR20010024482A (pt)
CN (1) CN1281358A (pt)
AP (1) AP1223A (pt)
AU (1) AU9547198A (pt)
BG (1) BG104405A (pt)
BR (1) BR9815220A (pt)
CA (1) CA2305289A1 (pt)
CZ (1) CZ20001298A3 (pt)
EA (1) EA200000418A1 (pt)
GB (1) GB9721692D0 (pt)
HR (1) HRP20000256A2 (pt)
HU (1) HUP0003673A3 (pt)
ID (1) ID24439A (pt)
IL (1) IL135515A0 (pt)
NO (1) NO20001897L (pt)
OA (1) OA11519A (pt)
PL (1) PL339804A1 (pt)
SK (1) SK5322000A3 (pt)
TR (1) TR200000957T2 (pt)
UA (1) UA66809C2 (pt)
WO (1) WO1999018944A1 (pt)
YU (1) YU28700A (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
AP2001002036A0 (en) * 1998-07-21 2001-03-31 Smithkline Beecham Plc Use of glucose uptake enhancer for reducing apoptosis.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306228B1 (en) * 1987-09-04 1999-11-17 Beecham Group Plc Substituted thiazolidinedione derivatives
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5457109A (en) * 1993-09-15 1995-10-10 Warner-Lambert Company Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus

Also Published As

Publication number Publication date
YU28700A (sh) 2003-10-31
AP2000001788A0 (en) 2000-06-30
CA2305289A1 (en) 1999-04-22
OA11519A (en) 2004-02-09
EP1023057A1 (en) 2000-08-02
WO1999018944A1 (en) 1999-04-22
AU9547198A (en) 1999-05-03
PL339804A1 (en) 2001-01-02
JP2001519383A (ja) 2001-10-23
BR9815220A (pt) 2000-11-14
NO20001897D0 (no) 2000-04-12
CZ20001298A3 (cs) 2001-08-15
TR200000957T2 (tr) 2000-08-21
NO20001897L (no) 2000-06-09
EA200000418A1 (ru) 2000-10-30
HRP20000256A2 (en) 2000-12-31
HUP0003673A2 (hu) 2001-10-28
IL135515A0 (en) 2001-05-20
AP1223A (en) 2003-11-13
HUP0003673A3 (en) 2001-12-28
GB9721692D0 (en) 1997-12-10
BG104405A (en) 2000-12-29
UA66809C2 (uk) 2004-06-15
KR20010024482A (ko) 2001-03-26
SK5322000A3 (en) 2000-09-12
ID24439A (id) 2000-07-20

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication