CN1261783A - Compositions containing select solid polyol fatty acid polyesters - Google Patents
Compositions containing select solid polyol fatty acid polyesters Download PDFInfo
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- CN1261783A CN1261783A CN98806780A CN98806780A CN1261783A CN 1261783 A CN1261783 A CN 1261783A CN 98806780 A CN98806780 A CN 98806780A CN 98806780 A CN98806780 A CN 98806780A CN 1261783 A CN1261783 A CN 1261783A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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Abstract
本发明涉及一种适于局部施用到人头发或皮肤上的组合物,该组合物含有熔点为约30℃至约80℃的固体多元醇脂肪酸多酯和熔点低于约30℃至约－30℃的液体油,该液体油不是固体多元醇脂肪酸多酯,其中所述的固体多元醇脂肪酸多酯含有多元醇结构部分和至少一个脂肪酸结构部分,多元醇结构部分含有至少4个游离羟基,其中至少60%的游离羟基被一个或多个具有约8个至约22个碳原子的脂肪酸结构部分所酯化。该组合物优选进一步含有液体多元醇脂肪酸多酯和固体油的载体。该组合物能提供有效的软化作用和美观优势。The present invention relates to a composition suitable for topical application to human hair or skin comprising a solid polyol fatty acid polyester having a melting point of from about 30°C to about 80°C and a solid polyol fatty acid polyester having a melting point of less than about 30°C to about -30°C The liquid oil at ℃, the liquid oil is not a solid polyol fatty acid polyester, wherein the solid polyol fatty acid polyester contains a polyol structural part and at least one fatty acid structural part, and the polyol structural part contains at least 4 free hydroxyl groups, wherein At least 60% of the free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms. The composition preferably further comprises a liquid polyol fatty acid polyester and a solid oil carrier. The composition provides effective softening and aesthetic benefits.
Description
Technical field
The present invention relates to a kind of compositions that is suitable for locally applying on human hair or the skin, it is about 30 ℃ of selection combinations that are lower than 30 ℃ to about-30 ℃ liquid oil to about 80 ℃ solid polyol fatty acid polyesters and fusing point that said composition contains fusing point.
Background of invention
Aspect handler's hair or skin, contain the existing application practice for many years of topical compositions of softening agent.For example, occlusive Hydrocarbon such as vaseline can form protecting film as the local softening agent and prevent that water loss is in environment at people's skin surface.Vaseline also has been applied in the hair products, as conditioner and modification auxiliary agent.
But the most effective and the most widely used compositions that contains the occlusive softening agent but has the defective of aesthetic, as greasy feeling and viscous sense.In addition, some can stop up pore and hinder the unobstructed of oxygen in order to the occlusive softening agent that the skin care film is provided.Because these heavy inaccessible emollient material have the skin of obstruction or hinder air and the unobstructed shortcoming of moisture, its application just is restricted.In addition, European patent 458,600B1 (on March 2nd, 1994 is open) discloses the occlusive skin care compositions that contains polyol fatty acid polyesters, this polyol fatty acid polyesters contains at least 4 free hydroxyl groups, wherein at least 60% is contained the fatty acid esterification of 8 to 22 carbon atoms by one or more, and it can form the film of occlusive at skin surface after local application.People's such as Macaulay United States Patent (USP) 5,160,738 (being issued on November 3rd, 1999) further discloses occlusive compositions mixture, that have vaseline outward appearance and physical characteristic that contains two or more polyol fatty acid polyesterss.It is unobstructed that but these compositionss also have thick and heavy shortcoming and stop up pore prevention oxygen.
Have been found that and to synthesize the compositions that contains the occlusive softening agent, said composition do not seem thick and heavy, greasy and viscous.It is the combination that about 30 ℃ of extremely about 80 ℃ solid polyol fatty acid polyesters and fusing point are lower than 30 ℃ to about-30 ℃ liquid oil that these compositionss contain fusing point, and these compositionss can be applied to various products, and these products not only have high effect but also have advantage attractive in appearance.
Therefore, the object of the present invention is to provide not only to have the efficient property of softening but also have the compositions of aesthetic property, said composition contains the combination of occlusive softening agent and solid oil.Another object of the present invention provides the topical compositions that contains polyol fatty acid polyesters, and said composition has good effect aspect handler's hair or the skin, and don't shows thick and heavy, greasy and viscous.
Summary of the invention
The present invention relates to a kind of compositions that is suitable for locally applying on human hair or the skin, the fusing point that said composition contains selection is about 30 ℃ of selection combinations that are lower than 30 ℃ to about-30 ℃ liquid oil to about 80 ℃ solid polyol fatty acid polyesters and fusing point, wherein said solid polyol fatty acid polyesters contains polyol structure part and at least one fatty acid structure part, polyol structure partly contains at least 4 free hydroxyl groups, and wherein at least 60% free hydroxyl group is had about 8 fatty acid structure part institute esterifications to about 22 carbon atoms by one or more.Said composition preferably further contains and is applicable to solid polyol fatty acid polyesters and the bonded topical vehicle of liquid oil.
Except as otherwise noted, all percentage ratios used herein and ratio all by weight, all measurements all are to carry out under 25 ℃ of conditions.The present invention can comprise, by or form by neccessary composition and non-essential component basically.
Detailed Description Of The Invention
The term of Shi Yonging " topical skin care compositions " means a kind of compositions that is adapted at the application of human body skin surface local in addition.This term is used for comprising various personal nursings, aesthetic nursing and make-up composition.The non-limitative example of topical compositions comprises water preparation, cream frost, hands usefulness and body and function washing liquid, skin condition liquid and skin condition frost, Derma-Guard compositions, sunscreen composition, cold cream, anti-acne composition, skin regeneration product, non-alveolitoid cleanout fluid, humidizer, facial moisturizer, cosmetics, foundation cream, lip pomade, lip care agent, skin cleaner, hand, face and clean body agent, bath product, shampoo and similar material.
The term of Shi Yonging " local application carrier " is a kind of ordinary skill well known in the art herein, means to be suitable for human body compatible solid or liquid filling diluent or the vehicle of one or more kinds easy to use.Term used herein " compatible " mean the local application carrier composition can with composition blend of the present invention, and mutually mix, under normally used situation, do not have the interaction that can cause cosmetic composition effectiveness and aesthetic property to reduce and take place.This local application carrier must be a kind of pharmaceutically useful carrier.Term used herein " pharmaceutically acceptable " means this local application carrier must sufficiently high purity, and is applicable to human body skin or hair and contacts, and unlikelyly causes toxicity, uncomfortable, unstable, anaphylaxis and similarly side effect.
The fusing point of liquid polyol fatty acid polyesters and solid oil can be measured with routine techniques.Such technology is known in the art, comprises thermometry and calorimetry.The technical description of especially preferred mensuration fusing point licenses to people's such as Letton U.S.P.No.5 on April 26th, 1994, in 306,514, be incorporated herein by reference in full at this, this method typically relates to differential scanning calorimetry (DSC) measures fusing point, and the scanning temperature is 5 ℃/minute.Fusing point is that baseline is promptly than the temperature of the intersection point of hot line and endothermic peak afterbody tangent line.
Solid polyol fatty acid polyesters
The present composition comprises solid polyol fatty acid polyesters, its concentration be composition weight about 0.1% to about 99.9%, be preferably about 0.5% to about 75%, more preferably about 1% to about 50%, especially more preferably about 2% to about 25%.The fusing point of these solid polyol fatty acid polyesters is about 30 ℃ to about 80 ℃, and being derived from how alcohol of any fat that contains at least 4 free hydroxyl groups or fragrance, at least 60% free hydroxyl group is wherein contained the 8 fatty acid institute esterifications to about 22 carbon atoms of having an appointment by one or more.Fatty acid also can be described as carboxylic acid, because term fatty acid and carboxylic acid often can exchange among those skilled in the art.
The solid polyalcohol polyester that uses among the present invention is polyol ester or polyester, wherein the fatty acid ester group of polyester contains following combination: (a) mixture of long-chain unsaturated fatty acid part or long-chain unsaturated fatty acid part and short chain saturated fat acid moieties, and (b) chain saturated fatty acids part, (a) with (b) ratio from about 1: 15 to about 2: 1.The total fatty acids part weight of polyester at least about 15%, preferably at least about 30%,, be C20 or more high-grade saturated fat acid moieties most preferably at least about 60% more preferably at least about 50%.Long-chain unsaturated fatty acid partly typically is straight chain and contains at least about 12, and preferably about 12 to about 22, more preferably about 18 to about 22 carbon atoms.Best unsaturated fatty acid is the single and/or two unsaturated fatty acids of C18.The short chain satisfied fatty acid typically is unbranched and contains has an appointment 2 to about 12, preferably about 6 to about 12, most preferably about 8 to about 12 carbon atoms.Chain saturated fatty acids typically is straight chain and contains at least about 20, and preferably about 20 to about 22, most preferably about 22 carbon atoms.(a) organizes fatty acid part and (b) organizes the mol ratio of fatty acid part from about 1: 15 to about 2: 1, preferably from about 1: 7 to about 5: 3, more preferably from about 1: 7 to about 3: 5 in the polyester molecule.It is esterified that the average esterification degree of these fatty acid esters is at least about 60% hydroxyl groups.For sucrose polyfatty acid esters preferably have an appointment 7 to about 8 polyhydric alcohol hydroxyls esterified.Usually, whole substantially, as at least about 85%, preferably esterified at least about 95% polyhydric alcohol hydroxyl.
The preferred polyhydric alcohols of solid polyol fatty acid ester is a sugar, and sugar is selected from monosaccharide, disaccharide and trisaccharide, contain from about 4 to about 11, preferably from about 4 to about 8, most preferably from about 6 to about 8 hydroxyls.The example that contains the polyhydric alcohol of four hydroxyls has monosaccharide xylose, arabinose and combination thereof.The suitable polyhydric alcohol that contains five hydroxyls has monosaccharide galactose, fructose, mannose, glucose and combination thereof.The example of operable two sugar polyols has maltose, lactose, sucrose and combination thereof, contains eight hydroxyls all.Preferred polyhydric alcohols is a sucrose.
The example of long-chain unsaturated fatty acid part has, but is not limited to myrcene acid esters, myristicol acid esters, palm acid ester, oleate, elaidic acid ester, eruciate, linoleate, linolenate, arachidonate, eicosapentaenoic acid esters and docosahexenoic acid ester.For oxidation stability, single or two unsaturated fatty acids acid moieties are best.
The example of suitable short chain saturated fat acid moieties has, but is not limited to acetas, alkyl caproate, caprylate, decanoin and laurate.
The example of suitable chain saturated fatty acids part has, but is not limited to Arachidate, behenic acid ester, haze tallow acid esters and cerotate.
Certainly, long-chain unsaturated fatty acid part can be separately or intermingling use or use with any mixed with short chain saturated fat acid moieties.Equally, the chain saturated fatty acids part can be used in combination with any ratio mutually.The mixing-in fat acid moieties that comes from the source oil that contains required in a large number unsaturated or saturated acid can be used as acid moieties, to prepare the mixture that uses herein.The fatty acid mixed that comes from source oil should contain at least about 30%, preferably at least about 50%, most preferably at least about 80% required unsaturated or saturated acid.For example, can replace pure C12-C16 unsaturated fatty acid with rapeseed oil fatty acid or soya fatty acid.Can be that the high canola fatty acid of hydrogenation replaces pure C20-C22 saturated acid with sclerosis, preferably C20 and more higher acid, or derivatives thereof as methyl or other lower alkyl esters, concentrates by methods such as distillations.The fatty acid of palm-kernel oil or Oleum Cocois can be as the source of C8 to C12 acid, use source oil with the example for preparing the solid polyalcohol polyester that uses in the compositions herein is, with senior Oleum helianthi and substantially fully the fatty acid of hydrogenant high canola prepare the solid sucrose polyfatty acid esters.Sucrose with the mixture of 1: 3 weight ratio of the fatty acid methyl ester of these two kinds of oil substantially fully after the esterification, unsaturated C18 acid group is about 1: 1 with the mol ratio that C20 reaches more high-grade saturated acid group in the sucrose polyfatty acid esters that produces, and in the polyester total fatty acids weight about 28.6% be the C22 fatty acid.
The ratio that is used for preparing the required unsaturated and saturated acid of the raw material of fatty acid of solid polyalcohol polyester is high more, and ester is strong more with the adhesive power of hereinafter described liquid oil.
The example of the solid polyol fatty acid polyesters that uses in the compositions has herein, but is not limited to the Raffinose octaester, and wherein the fatty acid part of esterification is that mol ratio is that 1: 3 linoleate is with the behenic acid ester; Maltose seven esters, wherein the fatty acid part of esterification is that mol ratio is 3: 4 Oleum Helianthi fatty acid and a haze tallow acid esters; The sucrose octaester, wherein the fatty acid part of esterification is that mol ratio is that 2: 6 oleate is with the behenic acid ester; And the sucrose octaester, wherein the fatty acid part of esterification is that mol ratio is 1: 3: 4 laurate, linoleate He a behenic acid ester.Best raw material is a sucrose polyfatty acid esters, and wherein esterification degree is 7-8, and fatty acid part is the single and/or two unsaturated acids of C18 with behenic acid, and the mol ratio of unsaturated acids ∶ behenic acid is 1: 7 to 3: 5.Best polyol ester is the sucrose octaester, wherein have an appointment in the molecule 7 parts of mountain Yu fatty acids and about 1 part of oleic acid.
Solid fatty acid polyester herein can be according to the method preparation of knowing in the existing technical merit for preparing polyol polyester.See No. 5,306,516, the United States Patent (USP) of authorizing people such as Letton on April 26th, 1994; No. 5,306,515, people's such as mandate on April 26th, 1994 Letton United States Patent (USP); No. 5,305,514, people's such as mandate on April 26th, 1994 Letton United States Patent (USP); No. 4,797,300, people's such as mandate on January 10th, 1989 Jandacek United States Patent (USP); No. 3,963,699, people's such as mandate on June 15th, 1976 Rizzi United States Patent (USP); No. 4,518,772, the United States Patent (USP) of mandate on May 21st, 1985 Volpenhein; No. 4,517,360, the United States Patent (USP) of mandate on May 21st, 1985 Volpenhein; All these are quoted as a reference in this integral body.
Liquid oil
The present composition comprises a kind of liquid oil, and this liquid oil is used with solid polyol fatty acid polyesters as described herein.Can be used alone liquid oil or use the combination of multiple liquid oil, its concentration range be composition weight about 0.1% to about 99.9%, preferred about 0.5% to about 75%, more preferably from about 1% to about 50%, especially preferred about 2% to about 25%.
" liquid oil " of Shi Yonging refers to fusing point and is lower than about 30 ℃ herein, preferably from about 30 ℃ to-30 ℃ approximately, more preferably from about 27.5 ℃ to-30 ℃ approximately, especially preferably from about 25 ℃ to-30 ℃ materials approximately.The liquid oil dissolubility in water usually is very little, is lower than about 1% weight under common 25 ℃ of conditions.The example of appropriate liquid oil has, but is not limited to mineral oil, contains 5 hydrocarbon to about 16 carbon atoms of having an appointment, contains 3 aliphatic alcohol esters to about 22 carbon atoms of having an appointment, contains have an appointment 3 fatty acid esters to about 30 carbon atoms, vegetable oil and composition thereof.Other liquid oil that is suitable for the present invention's use is described among people's such as disclosed Gordon on the 5th in January nineteen ninety-five the WO95-00166, is incorporated herein by reference in full herein.
The mineral oil of the Shi Yonging vaseline oil that is otherwise known as herein.The mixture that this chemical compound is made up of the liquid hydrocarbon that obtains from oil.With reference to Merck index, the 10th edition, 7048 sections, P.1033 (1983) and international cosmetic ingredient dictionary, the 5th edition, Vol.1, p.415-417 (1993) are incorporated herein by reference herein in full.
The suitable hydrocarbon that herein uses comprises having about 5 straight chain and branched-chain hydrocarbons to about 16 carbon atoms.The nonrestrictive example of these hydrocarbon has dodecane, Fancol ID, Parleam, hexadecane, 2-Methylpentadecane, and ((South Plainfield NJ) discusss the hydrocarbon Permethyl that sells by Presperse
).Also can use the isoparaffin of C5-C16 herein, i.e. the branched paraffin of C5-C16.
The suitable aliphatic alcohol ester that herein uses comprises and contains 3 ester and the diester to the aliphatic alcohol of about 22 carbon atoms of having an appointment.Containing 3 fatty acid esters to about 30 carbon atoms of having an appointment also can use.The limiting examples of these esters comprises isopropyl myristate, isopropyl palmitate, isopropyl stearate, diisopropyl adipate and di-n-octyl sebacate.
Also be applicable to the present invention for the vegetable oil of liquid to about 25 ℃ of conditions for about 20 ℃ in room temperature.The example of the vegetable oil that is fit to comprises cod-liver oil, dolphin oil, Adeps Sus domestica, neat's foot oil, dolphin oil, seal oil, sperm oil, whale oil, acorn oil, almond oil, beech nut oil, chaulmoogra oil, rapeseed oil, soybean oil, Oleum Helianthi, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Semen Maydis oil, safflower oil, olive oil, pilchardine, Oleum sesami, Oleum Ricini, hazelnut oil, hemp seed oil, Semen Lini oil, Semen Sinapis (deceiving) oil, Neem oil, Oleum Arachidis hypogaeae semen, pistachio nut oil, poppy seed oil, pumpkin seed oil, Oleum Verniciae fordii, white mustard oil, Oleum Pini, wheat germ oil and derivant thereof and mixture.
The local application carrier
The present invention comprises about 0.1% to about 99.9%, and preferred about 50% to about 99%, more preferably from about 60% carrier to the local application that is used for solid polyol fatty acid polyesters of the present invention and liquid oil combination and any other nonessential composition of about 95% weight.
Solid polyol fatty acid polyesters of the present invention and liquid oil combination can be mixed with the multiple product type, comprise emulsifiable paste, water preparation, emulsion, gel, hands usefulness and body and function washing liquid, cold cream, the agent of non-alveolitoid clean water, facial moisturizer, sunscreen, anti-acne formulations, local analgesia agent, mascara, lip pomade, skin cleaner, hand, face and body and function cleaning agent, bathe with product, shampoo etc.The carrier and any interpolation component that are used to prepare these products change with product type, and can be selected with conventional method by those skilled in the art.
The local application carrier can be in a variety of forms.Emulsion carriers for example includes but not limited to that here O/w emulsion, water-in-oil emulsion, Water-In-Oil water wrap not only the emulsion of oil and the emulsion of oil-in-water siloxanes but also Bao Shui.The range of viscosities of these emulsions is very wide, and 100cps is to about 200 according to appointment, 000cps.Other local application carrier that is suitable for comprises anhydrous liquid solvents, as pure and mild polysiloxanes (as ethanol, isopropyl alcohol, dimethicone, SILIBIONE OIL 70047 V20 DC-21330 DC21330 etc.); Water base single-phase liquid solvent (as the water-alcohol solvent system); The thickening form of and water base single-phase solvent anhydrous with these (as, by adding suitable natural gum, resin, form solid or semisolid thereby wax, polymer, salt etc. increase viscosity).The example that is used for local application carrier system of the present invention has description at the following document that is incorporated herein by reference in full: " Sun ProductsFormulary ", cosmetics and toilet articles, volume 105,122-139 page or leaf (nineteen ninety December); " Sun Products Formulary ", cosmetics and toilet articles, volume 102,117-136 page or leaf (in March, 1987); Grant people's such as Figueroa USP4960 764 October 2 nineteen ninety; Granted people's such as Fukuda USP 4254105 on March 3rd, 1981; Nineteen ninety, December granted people's such as Orr USP 4976953 on the 11st; Decembers in 1991 were granted people's such as Turner USP 5073372 on the 17th; Decembers in 1996 were granted people's such as Ha USP 5585104 on the 17th; Granted people's such as Moore USP 5607678 on March 4th, 1997; Granted people's such as McAtee USP 5607980 on March 4th, 1997; Grant people's such as Kaleta USP5618522 with on April 8th, 1997.
The local application carrier also can comprise a kind of O/w emulsion system, and this system has the labyrinth as liquid crystal and crystal gel network.The characteristic of the essence of liquid crystal, the formation of liquid crystal, liquid crystal and the anisotropy stratiform mutually oil-in-water characteristic of advantage at the G.Dahms work, 101 cosmetics and toilet articles, liquid crystal in 113-115 (1986) one literary compositions, in the cosmetic emulsion of P.Loll work, the heterogeneous O/w emulsion of showing with G.M.Eccleston in ICI surfactant communique RP94-93E one literary composition, 41, J.Soc.Cosmet.Chem., 1-22, in (January/February 1990) literary composition further description is arranged, above document all is incorporated herein by reference in full.
Add component
Can use a variety of interpolation components in the compositions of this paper.Nonrestrictive example is as follows: active constituents of medicine
Compositions of the present invention can contain the active constituents of medicine of certain safe and effective amount.Term used herein " safe and effective amount " means in the scope of correct medical judgment, live vol is enough high with can be obviously or improve situation to be treated really, but the enough low and unlikely serious adverse (with reasonably useful/harmful ratio) that causes of live vol.The safe and effective amount of pharmaceutically active is with the activity of concrete active component, the compositions character to persistent period of the order of severity of the penetrating ability of skin, the consumption of compositions, the specific condition of treatment, the age of being treated patient and physical qualification, the state of an illness, treatment, other Therapeutic Method of adopting simultaneously, and similar factor and changing.
The active constituents of medicine content that can in compositions of the present invention, use preferably account for composition weight about 0.1% to about 20%, more preferably about 0.1% to about 10%, and most preferably about 0.1% to about 5%.Also can use the mixture of active constituents of medicine.
The non-limitative example of active constituents of medicine comprises following material:
Available active constituents of medicine comprises anti-acne medicine in the compositions of the present invention.The anti-acne medicine that uses among the present invention comprises keratolytic such as salicylic acid, sulfur, lactic acid, glycolic, acetone acid, resorcinol and N-acetylcystein; Retinoid material such as retinoic acid derivatives (, trans isomer suitable) as it; Antibiotics and anti-little living agent such as benzoyl peroxide, Octopirox, erythromycin, zinc, tetracycline, two phenoxy chlorophenols, Azelaic Acid and derivant, phenyl phenol and phenoxypropanol, ethyl acetate, clindamycin and meclocycline; Sebostats such as flavonoid; α and beta hydroxy acid; Bile salts is scymnol sulfate and derivant thereof for example, dexycholate and cholate.Preferred anti-acne active component is selected from salicylic acid, sulfur, resorcinol, lactic acid, zinc, erythromycin, benzoyl peroxide and mixture thereof.Salicylic acid more preferably.
Available active constituents of medicine comprises non-steroidal anti-inflammatory drugs (NSAIDS) in the compositions of the present invention.NSAIDS is selected from following material: propanoic derivatives; Acetogenin; Fenamic acid derivatives; Xenyl carboxylic acid derivates and oxicams.All these NSAIDS authorize people's such as Sunshine U.S.P.4 on January 15th, 1991, carried out comprehensive description in 985,459, and these contents are all quoted as a reference at this.Propanoic acid NSAIDS most preferably, comprise following material, but be not limited in these: aspirin, acetyl amino phenyl, ibuprofen, naproxen, BENO, flurbiprofen, fenoprofen, fenbufen, Ketoprofen, indoprofen, Pirprofen, carprofen, Evil promazine, Pranoprofen, miroprofen, Tioxaprofen, suprofen, alkene phenalgin propanoic acid, Artiflam, fluorobenzene propanoic acid, bucloxic acid.Available steroid antibiotic medicine also comprises hydrocortisone and similar material.
Available pharmaceutically active comprises antipruritic in the compositions of the present invention.The antipruritic of admixing in the compositions of the present invention preferably comprises the salt of pharmaceutically useful Dilosyn and alimemazine.
Available pharmaceutically active comprises anesthetics in the compositions of the present invention.The anesthetics of admixing in the compositions of the present invention preferably comprises the salt of pharmaceutically useful lidocaine, marcaine, chloroprocaine, cincaine, clothing ferrum caine, mepivacaine, tetracaine, dyclonine, hexylcaine hydrochloride, procaine, cocaine, ketamine, pramoxine and these materials of phenol.
Available pharmaceutically active comprises antimicrobial drug (antibacterium class, antimycotic, protozoacide class and antiviral agents) in the compositions of the present invention.The antimicrobial drug of admixing in the compositions of the present invention preferably comprises pharmaceutically useful b-lactams medicine, Du-6859a, encircle the third fluorine chloromycetin, norfloxacin, tetracycline, erythromycin, the fourth kanamycin, triclosan, doxycycline, capreomycin, chlohexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, metronidazole, pentamidine, gentamycin, kanamycin, the line mycin, methacycline, hexamethylenamine, minomycin, neomycin, ethyl sisomicin, paromomycin, streptomycin, tobramycin, mikonomycin and amanfadine.The antimicrobial drug of admixing in the compositions of the present invention preferably comprises quadracycline, erythromycin propionate lauryl sulfate, Erythromycin Stearate (salt), amikacin sulfate, doxycycline hyclate, capreomycin sulfate Capastat sulfate, chlorhexidine gluconate, chlorhexidine dihydrochloride, chlortetracycline hydrochloride, tetramycin hydrochloride, Luijiemycin Hydrochloride, ebutol, the hydrochloric acid metronidazole, the hydrochloric acid pentamidine, gentamycin sulfate, kanamycin sulfate, hydrochloric acid line mycin, methacycline hydrochloride, methenamine hippu, hexamine mandelate, the hydrochloric acid minomycin, polygynax, netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, obracine, the hydrochloric acid mikonomycin, hydrochloric acid amanfadine, sulphuric acid amanfadine, triclosan, Octopirox, parachlorometaxylenol, nystatin, tineatonsurans is moved back the salt with these materials of Cray azoles.
Here available also have sun-proof reagent.A variety of sun-proof reagent have been described: people's such as mandate on February 11st, 1992 Haffey U.S.P.No.5,087,445 in following article; People's such as December in 1991 mandate on the 17th Turner U.S.P.No.5,073,372; People's such as December in 1991 mandate on the 17th Turner U.S.P.No.5,073,371; People such as Segarin, chapter 8, after 189 pages, " cosmetic science and technology ", above all the elements are all quoted as a reference at this.In compositions of the present invention in the available sun-proof reagent, preferably be selected from p-methoxycinnamic acid 2-Octyl Nitrite, N, N-dimethyl para-amino benzoic acid 2-Octyl Nitrite, para-amino benzoic acid, 2-Phenylbenzimidazole-5-sulphuric acid, octocrilene, oxybenzone, the high ester of salicylic acid, ethylhexyl salicylate, 4,4 '-methoxyl group-t-butyl dibenzoyl methane, 4-isopropyl diphenyl formyl methane, 3-benzylidene Camphora, 3-(4-methylbenzene methylene) Camphora, titanium dioxide, zinc oxide, Silicon stone, ferrum oxide, and their mixture.
Also have some other available sunscreen open in following patent: to authorize the U.S.P.No.4 of Sabatelli, 937,370 June 26 nineteen ninety; People's such as mandate on March 12nd, 1991 Sabatelli U.S.P.No.4,999,186; This two parts reference content is all quoted as a reference at this.Wherein in disclosed sun-proof reagent individual molecule 2 different chromophores with different ultraviolet radiation absorption spectrums are arranged.One of them chromophore mainly absorbs in the UVB radiation scope, and another absorbs in the UVA radiation scope by force.Compare with common sun-proof reagent, these sun-proof reagent are more effective, and the uv absorption scope is wideer, are difficult for penetrating into skin and effectiveness longer duration.Particularly preferred sun-proof reagent is selected from 2, the 4-N of 4-dihydroxy benaophenonel, N-(2-ethylhexyl) methylamino benzoate, the 4-N that forms with 4-hydroxy benzophenone acyl methane, the 4-N of N-(2-ethylhexyl) methylamino benzoate, 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone, the 4-N of N-(2-ethylhexyl) methylamino benzoate, 4-(2-hydroxyl-oxethyl) dibenzoyl methane, N-(2-ethylhexyl) methylamino benzoate, and their mixture.
Usually, sunscreen used herein can account for about 0.5% to about 20% of compositions.Its accurate consumption changes with selecteed sunscreen and desired sun protection factor (SPF).SPF is generally used for weighing sunscreen and prevents that illumination from playing erythema.See Federal Register, the 43rd volume, No.166, pp.38206-38269, on August 25th, 1978, this part content is all quoted as a reference at this.
Available among the present invention also have non-Exposure to Sunlight type suntan, comprises dihydroxy acetone, glyceraldehyde, indole and derivant thereof, and similar material.These non-Exposure to Sunlight type suntans also can use with sunscreen is mixed.
Other available active component comprises Porcelana Skin Bleaching Agent Porcelana (or brightening agent), comprises following material, but is not limited only to this: hydroquinone, ascorbic acid, kojic acid and sodium metabisulfite.Wetting agent and humidizer:
Compositions of the present invention also contains one or more other wetting agent or humidizers except above-mentioned substance.Many kinds of this class material all may be utilized and every kind content be composition weight about 0.1% to about 20%, more preferably from about 1% to about 10%, most preferably from about 2% to about 5%.These materials comprise: guanidine, glycolic and glycollate (as ammonium and season alkylammonium); Lactic acid and lactate (as ammonium and season alkylammonium); Multi-form Aloe (for example Aloe glue); Polyhydric alcohol is as sorbitol, glycerol, hexanetriol, propylene glycol, butanediol, hexanediol etc.; Polyethylene Glycol; Sugar and starch; The derivant of sugar and starch (as oxyalkylated glucose); Hyaluronic acid; The lactamide monoethanolamine; The acetamide monoethanolamine; And their mixture.Emulsifying agent
Said composition also contains various emulsifying agents.These emulsifying agents are used for the various carrier component of emulsifying said composition.The surfactant that is suitable for comprises multiple non-ionic, cationic, anion and zwitterionic emulsifying agent, in these former patents and other list of references explanation is arranged all.Referring to, " detergent and emulsifying agent " (North America version) by the McCutcheon of Allured Publishing Corporation publication in 1986; The people's such as Ciotti that on April 30th, 1991 authorized U.S. Patent No. 5,011,681; The people's such as Dixon of nineteen eighty-three December mandate on the 20th U.S. Patent No. 4,421,769; The people's such as Dickert that on August 28th, 1973 authorized U.S. Patent No. 3,755,560; These four pieces of documents here in full as a reference.
Suitable emulsifying agent comprises ester, the polymers of carboxylic acid of ester, the anhydro sorbitol acid anhydride of fatty acid ester, the sorbitol of fatty acid ester, the polypropylene glycol of ester, the Polyethylene Glycol of ester, the propylene glycol of glycerol, ester and ether, ethyoxyl ether, ethoxy alcohol, alkyl phosphate (salt), polyoxyethylene aliphatic ether phosphate ester (salt), fatty acid amide, lactic acid acyl ester, soap and their mixture of glucose.
Suitable emulsifying agent can comprise, but be not limited only to: mono laurate Polyethylene Glycol 20 Isosorbide Dinitrates (Polysorbate 20), Polyethylene Glycol 5 soyasterols, Steareth-20, Ceteareth-20, distearyl acid PPG-2 methyl glucoside ether-ether, Ceteth-10, Polysorbate 80, cetyl phosphate ester (salt), cetyl phosphate ester potassium, cetyl p diethylaminobenzoic acid hydramine, Polysorbate 60, tristerin, PEG-100 stearate, and their mixture.
Emulsifying agent can use separately or use with the form of mixture of two or more, and its content in compositions of the present invention is about 0.1% to about 10%, more preferably about 1% to about 7%, most preferably about 1% to about 5% of composition weight.The polymers of carboxylic acid thickening agent
Another component is the polymers of carboxylic acid thickening agent in the present composition.These crosslinked polymer contain one or more monomers, these monomers are by acrylic acid, substituted acrylic acid, or these acrylic acid and substituted acrylic acid salt or ester are derived, wherein cross-linking agent contains two or more carbon-to-carbon double bonds, and it is by polyol derivative.Here preferred polymer has two big classes.First kind polymer is that (be that acrylic acid has substituent group on two or three carbon locations, these substituent groups are selected from C to the acrylic monomers or derivatives thereof separately
1-4Alkyl ,-CN ,-COOH, and their mixture) cross-linked homopolymer.Second base polymer is two kinds of monomeric cross-linked copolymers, and wherein a kind of monomer can be selected from acrylic monomers or derivatives thereof (just as described above), and short chain alcohol (is C
1-4) the acrylate monomer or derivatives thereof (be that acrylate moiety in the ester has substituent group on two or three carbon locations, these substituent groups are selected from C separately
1-4Alkyl ,-CN ,-COOH and their mixture), and their mixture; Second kind of monomer is that long-chain alcohol (is C
8-40) the acrylate monomer or derivatives thereof (be that acrylate moiety in the ester has substituent group on two or three carbon locations, these substituent groups are selected from C separately
1-4Alkyl ,-CN ,-COOH, and their mixture).Also can be used in combination this two base polymer among the present invention.
In the first kind cross-linked homopolymer, monomer whose is acrylic acid preferably, methacrylic acid, ethylacrylic acid, and their mixture, and acrylic acid most preferably.In the second class cross-linked copolymer, the acrylic monomers or derivatives thereof is acrylic acid preferably, methacrylic acid, ethylacrylic acid, and their mixture, and acrylic acid most preferably, methacrylic acid, and their mixture.The acrylate monomer or derivatives thereof of short chain alcohol is acrylic acid C preferably
1-4Alcohol ester, methacrylic acid C
1-4Alcohol ester, ethylacrylic acid C
1-4Alcohol ester, and their mixture, and acrylic acid C most preferably
1-4Alcohol ester, methacrylic acid C
1-4Alcohol ester and their mixture.Acrylate long-chain alcohol ester monomer can be selected acrylic acid C
8-40Arrcostab, preferably acrylic acid C
10-30The alkyl alcohol ester.
Cross-linking agent in this two base polymer is a kind of polyene-based polyether of polyhydric alcohol, contains the alkenyl ether group more than in its each molecule, and the parent polyhydric alcohol in the cross-linking agent contains at least 3 carbon atoms and at least 3 hydroxyls.Preferred cross-linking agents is selected from the allyl ether of sucrose and the allyl ether of tetramethylolmethane, and their mixture.People's such as mandate on February 11st, 1992 Haffey U.S.P No.5,087,445; People's such as mandate on April 5th, 1985 Huang U.S.P.No.4,509,949; Authorize the U.S.PN.o2 of Brown July 2 nineteen fifty-seven, the polymer that uses among the present invention is had more full and accurate description in 798,053.These contents are all quoted as a reference fully at this.Reference " CTFA international cosmetic ingredient dictionary " again, the 4th edition, 1991, pp.12 and 80; Wherein content is quoted as a reference fully at this.
The example of the commercially available homopolymer of the first kind that the present invention is used comprises carbopol preparation (carbomer), and it is with the crosslinked acrylate homopolymer of the allyl ether of sucrose or tetramethylolmethane.The Carbopol that commercial carbopol preparation is produced for the B.F. Goodrich
900 series.The example of the commercial copolymer of second class that the present invention is used comprises acrylic acid C
10-30Arrcostab and one or more monomeric copolymers, these monomers can be acrylic acid, methacrylic acid or their short chain (are C
1-4Alcohol) a kind of in the ester, wherein cross-linking agent is the allyl ether of sucrose or tetramethylolmethane.Known these copolymers are acrylate/acrylic acid C
10-30The Carbopol that the cross linked polymer of Arrcostab, these commercially available polymer have the B.F. Goodrich to produce
1342, Pemulen TR-1 and Pemulen TR-2.In other words, the used carboxylic acid polymer thickeners useful of the present invention can be selected from carbopol preparation, acrylate/acrylic acid C
10-30The cross linked polymer of Arrcostab, and their mixture.
The content of carboxylic acid polymer thickeners useful is about 0.025% to about 1%, more preferably about 0.05% to about 0.75%, most preferably about 0.10% to 0.50% in the compositions of the present invention.
Other adds composition
Compositions of the present invention can contain a large amount of other adding ingredients." CTFA cosmetic composition handbook " (the 2nd edition, 1992) described the cosmetic composition and the pharmaceutical compositions of various indefinitenesses commonly used in the skin care item industry, all is applicable to the present invention, is incorporated herein by reference.At 537 pages of non-limiting examples of having described the functional classification of composition of this book.The example of the composition of functional classification comprises absorbent, abrasive material, anti-acne agents, anticaking agent, defoamer, antimicrobial, antioxidant, binding agent, bio-additive, buffer agent, filler, chelating agen, chemical addition agent, coloring agent, the used for cosmetic astringent, the used for cosmetic biocide, denaturant, medicinal astringent, film former, fragrance component, opacifiers, the pH regulator agent, plasticizer, antiseptic, propellant, Reducing agent, other skin protectant, suspending agent (non-surface-active agent), UV absorbent, viscosifier (moisture or not moisture).Other functional category that is applicable to this relevant raw material well known to those of ordinary skill in the art also has solubilizing agent, sequestering agent etc.
Also comprise following material at these non-limiting example and other materials that are applicable to this that add composition described in " CTFA cosmetic composition handbook ": vitamin and derivant thereof [for example, vitamin C, vitamin A (being tretinoin), retinol, retinoid etc.]; Antioxidant; Polyethylene Glycol and polypropylene glycol; The polymer that helps compositions film property and affinity is (as the copolymer of eicosylene and vinylpyrrolidone, available from the Ganex of GAF chemical company
V-220); The antiseptic that keeps the antibiotic integrity of said composition; Antioxidant; Chelating agen and sequestering agent; Crosslinked or not crosslinked nonionic and PAMC are [for example, available from the Salcare SC92 of the CTFA called after polyquaternary ammonium salt 32 of Seppic company (with) mineral oil, and the Salcare SC95 of CTFA called after polyquaternary ammonium salt 37 (with) mineral oil (with) PPG-1 trideceth-6, and nonionic Seppi-Gel polyacrylamide]; With aesthstic composition such as spice, pigment, pigment, essential oil, s skin S enates, astringent, skin stretching agent, skin healing agent etc., the non-limiting example of aesthstic composition comprises: cloves oil, menthol, Camphora, Eucalyptus oil, acetaminol, lactic acid ester, Radix Hamamelidis Mollis distillate, bisabolol, glycyrrhizic acid dipotassium etc.
Using method
Use reason compositions of the present invention with traditional method, beauty treatment or medicinal effects can be arranged, and for example sun-proof, anti-acne, wrinkle resistant, anti-skin aging, manually tanned, pain relieving, skin condition, face heat, lip care, cleaning skin, modification auxiliary agent and similar effect.Such using method is relevant with the type of the compositions of use, but the common effective dose of application product on skin." effective dose " means the dosage that is enough to provide the effect that requires.The typical doses of applying the compositions of the present invention on hair or skin is relevant with desired effect with the type of compositions, and still, typical scope normally about 1 restrains about 25 grams, and typical dosage is about 2 grams.
Embodiment
Following examples will further describe and illustrate the embodiment in the scope of the invention.These embodiment only for purposes of illustration, not being interpreted as is limitation of the present invention, because in essence of the present invention and scope, also has many kinds of schemes.
Each component is all represented with chemical name or CTFA title.Embodiment 1
By using conventional hybrid technology following ingredients to be mixed the topical composition for preparing with softening agent cleaning agent form.Said composition uses the mixture of solid polyol fatty acid polyesters (solid sucrose polyfatty acid esters) and liquid oil that bating effect and aesthetic property are provided, and does not make skin that thick and heavy, greasy and viscid sensation is arranged.
Composition percetage by weight A phase EDTA disodium 0.100 glycerol 4.000 methyl parahydroxybenzoate 0.200 acrylate/acrylic acid C10-C30 alkyl ester cross-linked polymer
10.150Carbomer 954
20.250 water is in right amount to 100B phase stearic acid 0.110 stearyl alcohol 0.875 cetanol 0.875 propylparaben 0.150Steareth-2 0.250Steareth-21 0.500 solid polyalcohol polyester31.0000C phase sodium hydroxide
40.130D phase decanedioic acid diisopropyl ester 1.500 isohexadecane 5.000E phase phenoxetols 0.500 essence 0.150F phase glucose amide 0.9601Pemulen from B.F. Goodrich Co.'s acquisition
TR-1
2Carbomer from B.F. Goodrich Co.'s acquisition
954
3Solid sucrose octaester has oleic acid and seven Ge behenic acid structure divisions
450% aqueous solution
In suitable containers, the composition of A phase is at room temperature mixed the formation suspension, and be heated to 70-80 ℃ while stirring.In another container, the composition of B phase is heated to 70-80 ℃ while stirring.While stirring B is added to the middle mutually emulsion that forms of A then.Next, add C phase neutralization composition.Add the D phase constituent while stirring, be cooled to 45-50 ℃ then.Add the E phase constituent while stirring, be cooled to 40 ℃ then.F under agitation is heated to 40 ℃ mutually, joins in the emulsion, then composition cools is arrived room temperature.Embodiment 2
Prepare to bathe topical composition by using conventional hybrid technology that following ingredients is mixed with product form.Said composition uses the mixture of solid polyol fatty acid polyesters (solid sucrose polyfatty acid esters) and liquid oil that bating effect and aesthetic property are provided, and does not make skin that thick and heavy, greasy and viscid sensation is arranged.
Composition percentage by weight C12/14 alkyl ether glycerine sulphonic acid ester sodium 12.00 lauryl ethers-3 aluminum sulfate 3.00 myristic acids 1.00 myristyl alcohols 1.00 Cocoamidopropyl betaines 3.00 trihydroxy stearins 1.75 solid sucrose polyfatty acid esterses11.20EDTA four sodium, 0.13 glycerine 6.24 essence, 0.80 Polyquaternium-10s (JR-30M) 0.30Glydant, 0.20 Malaysia soybean oil, 1.00 water are in right amount to 1001Solid sucrose octaester has oleic acid and seven Ge behenic acid structure divisions
In a suitable containers, polyquaternary ammonium salt-10 joined mix in the distilled water until complete hydration.Add surfactant and water soluble ingredient then, be heated to 70-80 ℃ while stirring.In another container, the solid sucrose polyfatty acid esters is combined with liquid oil and trihydroxy stearin, heat while stirring until reaching homogeneous, join then in the mixture that is heated to 70-80 ℃.Under stirring condition, mixture is cooled to 25-35 ℃.Under agitation add glydant and perfume ingredient then, at last mixture is cooled to room temperature.Embodiment 3
Prepare the topical composition of bathing by using conventional hybrid technology that following ingredients is mixed with product form.Said composition uses the mixture of solid polyol fatty acid polyesters (solid sucrose polyfatty acid esters) and liquid oil that bating effect and aesthetic property are provided, and does not make skin that thick and heavy, greasy and viscid sensation is arranged.
Composition percentage by weight lauryl sulfate ester ammonium 3.15 lauryl ethers-3 ammonium sulfate 9.45 bay both sexes sodium acetates 5.40 Polyquaternium-10s 0.30 trihydroxy stearin 2.00 solid sucrose polyfatty acid esterses11.20EDTA four sodium, 0.13 glycerine, 3.00 essence, 0.80 citric acid, 0.76 laruyl alcohol, 2.00 mineral oil, 3.00 water are in right amount to 1001Solid sucrose octaester has oleic acid and seven Ge behenic acid structure divisions
In a suitable containers, polyquaternary ammonium salt-10 joined mix in the distilled water until complete hydration.Add surfactant and water soluble ingredient then, be heated to 70-80 ℃ while stirring.In another container, the solid sucrose polyfatty acid esters is combined with liquid oil, lauryl alcohol and trihydroxy stearin, heat while stirring until reaching homogeneous, join then in the mixture that is heated to 70-80 ℃.Under stirring condition, mixture is cooled to 25-35 ℃.Under agitation add glydant and perfume ingredient then, at last mixture is cooled to room temperature.Embodiment 4
By using conventional hybrid technology following ingredients to be mixed the topical composition for preparing the humidizer form.Said composition uses the mixture of solid polyol fatty acid polyesters (solid sucrose polyfatty acid esters) and liquid oil that bating effect and aesthetic property are provided, and does not make skin that thick and heavy, greasy and viscid sensation is arranged.
Composition percentage by weight cetanol 1.80 stearic acid 0.25 stearyl alcohol 1.20Peg 100 stearates 0.25 mineral oil 2.00 vaselines 1.50 isopropyl palmitates 1.00 ricinoleic acid cetyl 1.00 solid sucrose polyfatty acid esterses12.00 dimethicone 350
20.50 propyl p-hydroxybenzoate 0.10Arlatone (RTM) 2121
31.00 glycerol 9.00 ureas 2.00 octyl methoxycinnamates 2.00 phenyl phenol 0.25Carbomer 1382
40.05Carbomer 954
50.35EDTA four sodium, 0.10 titanium dioxide, 0.15 methyl parahydroxybenzoate 0.20NaOH, 0.22 dimethicone Q-21403
61.00 2-Methylpentadecane 1.00 water, have the Dow Corning that oleic acid and seven Ge behenic acid structure divisions 2 obtain from Dow Corning Corporation in right amount to 1001 solid sucrose octaesters
The Carbopol that stearic acid Isosorbide Dinitrate that 200 fluids (350 centistoke) 3 95% are heavy and 5% heavy coconut oil sucrose ester 4 obtain from B.F. Goodrich Co.
13825 Carbopol from B.F. Goodrich Co.'s acquisition
9546 Dow Corning from Dow Corning Corporation's acquisition
Q-2 1403, and it is the mixture of 85% heavy dimethicone and 15% heavy dimethiconal.
Prepare its first pre-composition by liquid sugar polyester, Arlatone 2121 and other water soluble ingredient being mixed and heating in water.By oil-phase component except polysiloxanes being mixed and heating prepares its second pre-composition, and second pre-composition is joined in the water pre-composition.Mixture cooling with gained.Then polysiloxanes is joined in the O/w emulsion of gained, before adding other submember, mixture is cooled off.
Claims (10)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86234597A | 1997-05-23 | 1997-05-23 | |
| US08/862,345 | 1997-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1261783A true CN1261783A (en) | 2000-08-02 |
Family
ID=25338279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98806780A Pending CN1261783A (en) | 1997-05-23 | 1998-05-20 | Compositions containing select solid polyol fatty acid polyesters |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0983048A1 (en) |
| JP (1) | JP2001517242A (en) |
| KR (1) | KR20010012848A (en) |
| CN (1) | CN1261783A (en) |
| AR (1) | AR015696A1 (en) |
| AU (1) | AU7227598A (en) |
| BR (1) | BR9812300A (en) |
| CA (1) | CA2289696A1 (en) |
| CO (1) | CO4940375A1 (en) |
| PE (1) | PE89599A1 (en) |
| WO (1) | WO1998052531A1 (en) |
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|---|---|---|---|---|
| AU9556898A (en) * | 1997-11-10 | 1999-05-31 | Procter & Gamble Company, The | Compositions containing combinations of solid polyol fatty acid polyesters and asolid oil |
| GB9902632D0 (en) | 1999-02-05 | 1999-03-31 | Unilever Plc | Hair treatment compositions |
| JP2002145758A (en) * | 2000-09-04 | 2002-05-22 | Kose Corp | Cosmetic |
| US7763587B2 (en) * | 2002-06-13 | 2010-07-27 | L'oreal S.A. | Derivative of glucose and of vitamin F, compositions comprising it, uses and preparation process |
| DE10252396A1 (en) * | 2002-11-12 | 2004-05-27 | Beiersdorf Ag | Cosmetic cleaning composition containing alkali soaps, useful for cleaning skin, hair and nails, includes polyacrylate as thickener to improve temperature stability |
| DE102006022514A1 (en) * | 2006-05-15 | 2007-11-22 | Henkel Kgaa | Cosmetic agent with special sugar esters |
| US8936796B2 (en) | 2008-02-25 | 2015-01-20 | The Procter & Gamble Company | Hair care compositions comprising sucrose polyesters |
| EP2467124B1 (en) * | 2009-08-20 | 2016-08-17 | The Procter and Gamble Company | Hair care compositions comprising first and second sucrose polyesters |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8514975D0 (en) * | 1985-06-13 | 1985-07-17 | Sempernova Plc | Compositions |
| EP0383380B1 (en) * | 1989-02-17 | 1994-04-13 | Unilever N.V. | Edible fat-containing products |
| JP2887485B2 (en) * | 1989-08-09 | 1999-04-26 | 花王株式会社 | Oily cosmetics |
| US4966779A (en) * | 1989-12-21 | 1990-10-30 | Basf Corporation | Stable, water miscible emulsion comprising a fat-soluble vitamin |
| EP0541830A1 (en) * | 1991-11-09 | 1993-05-19 | ISP Van Dyk Inc. | Absorption base containing sucrose ester |
| ATE156972T1 (en) * | 1992-10-30 | 1997-09-15 | Procter & Gamble | INDIGESTIBLE, SOLID POLYOL POLYESTER POLYMERS CONTAINING FAT COMPOSITIONS WITH PASSIVE OIL LOSS CONTROL |
| FR2710854B1 (en) * | 1993-10-08 | 1995-12-01 | Oreal | Oil-in-water emulsion usable for obtaining a cream. |
| WO1996016636A1 (en) * | 1994-11-28 | 1996-06-06 | The Procter & Gamble Company | Topical skin care compositions containing thickened polyol carboxylic acid esters as skin conditioning agents |
-
1998
- 1998-05-20 KR KR1019997010813A patent/KR20010012848A/en not_active Ceased
- 1998-05-20 EP EP98919402A patent/EP0983048A1/en not_active Withdrawn
- 1998-05-20 WO PCT/IB1998/000787 patent/WO1998052531A1/en not_active Ceased
- 1998-05-20 BR BR9812300-9A patent/BR9812300A/en not_active IP Right Cessation
- 1998-05-20 JP JP55018098A patent/JP2001517242A/en not_active Ceased
- 1998-05-20 CN CN98806780A patent/CN1261783A/en active Pending
- 1998-05-20 PE PE1998000396A patent/PE89599A1/en not_active Application Discontinuation
- 1998-05-20 AU AU72275/98A patent/AU7227598A/en not_active Abandoned
- 1998-05-20 CA CA002289696A patent/CA2289696A1/en not_active Abandoned
- 1998-05-22 AR ARP980102390A patent/AR015696A1/en unknown
- 1998-05-26 CO CO98029444A patent/CO4940375A1/en unknown
Also Published As
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|---|---|
| PE89599A1 (en) | 1999-10-24 |
| JP2001517242A (en) | 2001-10-02 |
| CA2289696A1 (en) | 1998-11-26 |
| EP0983048A1 (en) | 2000-03-08 |
| CO4940375A1 (en) | 2000-07-24 |
| WO1998052531A1 (en) | 1998-11-26 |
| KR20010012848A (en) | 2001-02-26 |
| BR9812300A (en) | 2000-07-18 |
| AR015696A1 (en) | 2001-05-16 |
| AU7227598A (en) | 1998-12-11 |
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