CN1253159C - Health product of compound propolis and preparing method - Google Patents
Health product of compound propolis and preparing method Download PDFInfo
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- CN1253159C CN1253159C CNB2003101032410A CN200310103241A CN1253159C CN 1253159 C CN1253159 C CN 1253159C CN B2003101032410 A CNB2003101032410 A CN B2003101032410A CN 200310103241 A CN200310103241 A CN 200310103241A CN 1253159 C CN1253159 C CN 1253159C
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- propolis
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- folium ginkgo
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- 241000241413 Propolis Species 0.000 title claims abstract description 109
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- 238000000034 method Methods 0.000 title abstract description 9
- 150000001875 compounds Chemical class 0.000 title 1
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- 238000002360 preparation method Methods 0.000 claims abstract description 53
- 239000000843 powder Substances 0.000 claims abstract description 51
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The present invention discloses a composite propolis health care product and a preparation method thereof. The health care product is mainly prepared from propolis extract, Ginkgo leave extract, vitamin E and corn oil according to certain proportion. The preparation method comprises the steps that active ingredients of propolis and Ginkgo leaves are extracted by ethanol under certain conditions, and then an extract is obtained by condensing the active ingredients when pressure is reduced. After a baking procedure and a mesh screening procedure, the manufactured propolis extract powder and the Ginkgo leaf extract powder are mixed with a certain amount of vitamin E and corn oil. The heal care product can be made into soft capsules. The composite propolis health care product has no toxicity and the actions of improving immunity, adjusting blood fat concentration, etc.
Description
Technical field
The present invention relates to a kind of health product that improve body immunity, blood lipid regulation function and preparation method thereof, more specifically to composite propolis health product of materials such as a kind of propolis-containing extract, Folium Ginkgo extract, vitamin E and preparation method thereof.
Background technology
Along with the development of society and the raising of people's living standard, people more and more pay attention to the raising of quality of life, resist person in middle and old age's diseases such as all kinds of diseases, particularly coronary heart disease, atherosclerosis, hypertension.Keep vitality, improve body immunity, more and more cause people's attention, people begin to seek the health substance that improves body immunity, and corresponding some health foods of having developed, such as current Development and Production more contain Folium Ginkgo, the health product of fruit extract, and propolis is as free radical in the important elimination human body, the material that improves body immunity is but fully developed, particularly it and vitamin E and have the synergism of the materials such as Folium Ginkgo extract that are rich in ginkgetin and terpene lactone of important improvement effect not to be well studied and to develop to the human body cardiovascular and cerebrovascular vessel do not find function definite at present as yet, each composition synergism is good, the health product that the specific aim effect is strong.
Summary of the invention
An object of the present invention is to provide a kind of enhancing immunity, auxiliary adjustment of blood fat concentration, the composite propolis health product that effect obviously, function is definite, each composition synergism is good, with strong points.
Another object of the present invention provides a kind of preparation method of composite propolis health product.The present invention realizes by following content:
A kind of composite propolis nutritional solution, it mainly is to be made by the composition of following parts by weight:
130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin Es; 220～270 parts of Semen Maydis oil.
Its optimum ratio is made by the composition of following parts by weight:
150 parts of propolis extracts; 100 parts of Folium Ginkgo extract; 7 parts of vitamin Es; 243 parts of Semen Maydis oil.
Composite propolis soft capsule of the present invention mainly is to be made by the composition of following parts by weight: wherein capsule 's content composite propolis nutritional solution consists of: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin; 220～270 parts of Semen Maydis oil; Capsule glue shell materials are material commonly used and and conventional method preparation.
This soft capsule preferably is prepared from by the composition of following parts by weight: wherein capsule 's content composite propolis nutritional solution consists of: 150 parts of propolis extracts; 100 parts of Folium Ginkgo extract; 7 parts of vitamin Es; 243 parts of Semen Maydis oil; Capsule glue shell materials are material commonly used, and preparation according to a conventional method.
Its capsule glue shell materials parts by weight are preferably: 30 parts in gelatin; 75 parts of glycerol; 45 parts in water.
The preparation method of composite propolis nutritional solution of the present invention is:
It is mainly made by the composition of following portions by weight: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin Es; 220～270 parts of Semen Maydis oil, its preparation method is as follows:
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo by active ingredient extraction ratio 5%, and Folium Ginkgo is pulverized, standby;
B. the 9-12 that presses Folium Ginkgo weight doubly adds 50% ethanol in the Folium Ginkgo of pulverizing, extract under 95 ℃ of conditions and refluxed 1 hour, extracts altogether 3 times, and each ethanol consumption is identical, merges 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. the filtrate decompression that makes among the c is concentrated the extractum of relative density 1.35, vacuum 0.08Mpa 50 ℃ the time;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder, the extraction ratio of Folium Ginkgo active ingredient is 5%;
(2) preparation of propolis extract:
A. take by weighing propolis raw material by active ingredient extraction ratio 40%, and propolis raw material is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. with the propolis powder for preparing among a successively with 95%, 85%, 75% alcohol dipping of 3-6 times of propolis raw material weight, each ethanol consumption is identical, all dissolves 24 hours;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, when concentrating under reduced pressure gets 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder, the extraction ratio of effective bee glue components is 40%;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder, propolis extract powder and vitamin E, Semen Maydis oil are mixed in proportion, stir, be heated to 40 ℃;
B. the mixed liquor after the heating in (3) is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature.
The preparation method of composite propolis soft capsule of the present invention is:
It is prepared from by the composition of following portions by weight: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; Vitamin E 5-9 part; 220～270 parts of Semen Maydis oil; 30 parts in gelatin; 75 parts of glycerol; 45 parts in water, its preparation method comprises:
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo by active ingredient extraction ratio 5%, and Folium Ginkgo is pulverized, standby;
B. the 9-12 that at every turn presses Folium Ginkgo weight doubly adds 50% ethanol in the Folium Ginkgo of pulverizing, extract under 95 ℃ of conditions and refluxed 1 hour, extracts altogether 3 times, and each ethanol consumption is identical, merges 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. the filtrate decompression that makes among the c is concentrated the extractum of relative density 1.35, vacuum 0.08Mpa 50 ℃ the time;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder, the extraction ratio of Folium Ginkgo active ingredient is 5%;
(2) preparation of propolis extract:
A. take by weighing propolis raw material by active ingredient extraction ratio 40%, and propolis raw material is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. with the propolis powder for preparing among a, use 95%, 85%, 75% alcohol dipping of 3～6 times of propolis raw material weight successively, each ethanol consumption is identical, all dissolves 24 hours;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, when concentrating under reduced pressure gets 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder, the extraction ratio of effective bee glue components is 40%;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder, propolis extract powder and vitamin E, Semen Maydis oil are mixed in proportion, stir, be heated to 40 ℃;
B. the mixed liquor after the heating among a is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature;
(4) preparation of soft capsule:
A. glue preparation: in gelatin, glycerol, water input glue bucket, water-bath is heated, is dissolved, stirring, evacuation, puts into the glue bucket of insulation at last;
B. suppress film, preparation soft capsule: on the soft capsule pellet press, the nutritional solution that makes in (3) is circulated in the rubber softgel shell of glue preparation, makes soft capsule.
The present invention selects propolis extract, Folium Ginkgo extract, vitamin E, corn wet goods composition for use, and with they reasonable combination, make each composition effect produce synergism, thereby can improve immunity effectively, prevent aging, improve the human body cardio and vascular function.
Propolis: propolis is the classic famous medicine of medical treasure-house, the history in existing thousands of years, pharmaceutical research finds that propolis has multiple biological agent, as antibiotic, antiinflammatory, antiviral, pain relieving, anesthesia, promotion tissue regeneration, antitumor, antioxidation, antiulcer, influence metabolism, improve cardiovascular function etc.This research has been observed propolis HC has been caused immunologic hypofunction model mouse immune function influence, is that the clinical effect and the anti-ageing research of propolis provides experimental basis with it.This experimental result shows: (1) propolis can improve immunologic hypofunction Mus T total cellular score and L
3T
4, Lyt
2Cell divides rate and L in vain
3T
4/ Lyt
2Ratio; (2) propolis can be worked in coordination with the propagation that ConA promotes mouse lymphocyte, this shows that EEP has immunostimulant and immunoregulatory effect, and the cellular immune function that can make HC cause the immunologic hypofunction model mouse returns to normal level.
Folium Ginkgo: Folium Ginkgo is a kind of of many uses, natural materials of having no adverse reaction, China is used as medicine with it and has the history of more than one thousand years, countries in the world have been used its preparation for treating angina pectoris, brain aging, alzheimer disease, brain insufficiency, asthma etc. clinically at present, have received promising result.Its effective ingredient mainly is ginkgetin and terpene lactone.The removing free radical of Folium Ginkgo; the effect of antioxidation now is proved; it is by removing the oxidative damage that oxyradical can improve the animal blood vessels endotheliocyte; improve hemorheology thereby reach; blood vessel dilating, the effect of treatment coronary heart disease studies have shown that recently; Folium Ginkgo can also have the certain protection effect to treating myocardial ischemia damage to the mitochondrial lipid peroxidation of anti-myocardial.Utilize Folium Ginkgo can remove the characteristics of free radical, can reduce membrane fluidity and protein conformation change that free radical causes, play the effect of neuroprotective cell.As seen Folium Ginkgo can protect the cerebral cortex neurocyte to avoid the damage of free radical.
Vitamin E: leukocyte and Immune Effects are had many reports about VitE, can influence leukocytic chemotaxis as VitE, random migration and activate the phagocytic capacity, and mastitis patient's PMN (poltmorphonuclear leucocytes) vigor is improved; Can protect leukocytic function to the serious burn patient, and can prevent women's leukocyte function in puerperal to descend or the like.In the experiment, we cause the pathological model of leukopenia with CTX, observe the influence of VitE to model then, and the result shows that VitE can resist obviously that the inductive quantity of leucocyte of CTX descends and function reduces, the peripheral blood leucocyte counting is risen, and phagocytic activity of leukocytes strengthens.As everyone knows, the patient of leukopenia often shows as immunologic hypofunction simultaneously, so we also induce the animal model that has caused immunologic hypofunction with CTX, observe the influence of VitE simultaneously to model, found that VitE can obviously resist the inductive immunologic hypofunction state through CTX, thymus and spleen weight are increased; LgG content increases in the serum; The T lymphproliferation response increases, and can make also that IFN-γ content significantly improves in the blood, and we know, immunologic function is regulated in IFN-γ wide participation, very big to immunity of organism stability of network influence, when immunologic hypofunction, it is extremely beneficial that the increasing of IFN-γ content is undoubtedly body.
The effect of Semen Maydis oil: Semen Maydis oil is as the substrate of soft capsule, and rich in vitamin E simultaneously has the effect of antioxidation, defying age, raising immunity.
Composite propolis health product of the present invention have following beneficial effect:
(1) improves immunity (2) blood lipid regulation concentration (3) avirulence
Effect of the present invention further is verified by following animal experiment:
Provide the unit of following animal experiment survey report to be " disease prevention and control center, Hunan Province "
One. the test of safety toxicological evaluation:
1. sample title: silver-colored honeybee board silver honey soft capsule (being soft capsule trade name of the present invention)
2. sample character: dosage form: soft capsule content character: brown liquid
3. inspection item: acute oral toxicity (LD
50) measure, three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test), fed in 30 days
4. test basis: " toxicological evaluation of food safety procedure and method " GB15193-94
5. assay: silver-colored honeybee board silver honey soft capsule toxicological assessment result:
(1). acute oral LD
50Result: to acute oral LD female, male mice
50All, belong to non-poisonous material greater than 21500mg/kg.bw.
(2). three genetic toxicity test results: the result is negative for three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test).
(3) .30 days feeding trial results: the silver-colored honeybee board silver honey soft capsule content with 0.42g/kg.bw, 0.84g/kg.bw, 1.67g/kg.bw dosage was irritated stomach 30 days to rat oral, duration of test, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, internal organs/body weight ratio and matched group compare, there was no significant difference (P＞0.05).Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking.Point out this submitted sample to feed in 30 days the every observation index of rat is not produced obvious toxic-side effects.
6. brief summary
Silver honeybee board silver honey soft capsule is to acute oral LD female, male mice
50All, belong to non-poisonous material greater than 21500mg/kg.bw.The result is all negative for three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test).Silver-colored honeybee board silver honey soft capsule content with 0.42g/kg.bw, 0.84g/kg.bw, 1.67g/kg.bw dosage was irritated stomach 30 days to rat oral, duration of test, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, internal organs/body weight ratio and matched group compare, there was no significant difference (P＞0.05).Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking.Point out this submitted sample to feed in 30 days the every observation index of rat is not produced obvious toxic-side effects.
Two. blood lipid regulation effect animal experiment
1. sample title: silver-colored honeybee board silver honey soft capsule
2. sample character: dosage form: soft capsule content character: brown liquid
3. sample size: content: 3kg
4. inspection item: blood lipid regulation effect animal experiment
5. test basis: the health food function assessment assessment process and the method for inspection
6. assay:
With 0.083,0.167, the silver-colored honeybee board silver honey soft capsule content of 0.500g/kg.bw dosage gave rat oral gavage 30 days, compare with high fat matched group, 0.500g/kg.bw the dosage group can significantly reduce high lipid food Serum TC, the TG level (P＜0.05) of raising, to rat blood serum HDL-C level do not make significant difference (P＞0.05).Point out this sample to have the blood lipid regulation effect.
7. brief summary
With 0.083,0.167, the silver-colored honeybee board silver honey soft capsule content of 0.500g/kg.bw dosage gave rat oral gavage 30 days, compare with high fat matched group, 0.500g/kg.bw the dosage group can significantly reduce high lipid food Serum TC, the TG level (P＜0.05) of raising, to rat blood serum HDL-C level do not make significant difference (P＞0.05).Point out this sample to have the blood lipid regulation effect.
Three. the immunoregulation effect animal experiment
1. sample title: silver-colored honeybee board silver honey soft capsule
2. sample character: dosage form: soft capsule content character: brown liquid
3. inspection item: immunoregulation effect
4. test basis: Ministry of Public Health " the health food function assessment assessment process and the method for inspection "
5. assay:
Per os gives the silver-colored honeybee board silver honey soft capsule 30 days of mice 0.083g/kg.bw, 0.167g/kg.bw, 0.501g/kg.bw dosage, can improve the ability that delayed allergy, half hemolysis value, antibody-producting cell number, the monokaryon one macrophage carbon of mice are cleaned up.Weight of mice, thymus body weight ratio, spleen body weight ratio, the inductive mouse lymphocyte conversion capability of ConA, mouse macrophage are engulfed ability, the NK cell activity of chicken red blood cell and all do not had obvious influence.Point out this sample to have immunoregulation effect.
6. conclusion
Per os gives the silver-colored honeybee board silver honey soft capsule 30 days of mice 0.083g/kg.bw, 0.167g/kg.bw, 0.501g/kg.bw dosage, can improve the ability that delayed allergy, half hemolysis value, antibody-producting cell number, the monokaryon one macrophage carbon of mice are cleaned up.Weight of mice, thymus body weight ratio, spleen body weight ratio, the inductive mouse lymphocyte conversion capability of ConA, mouse macrophage are engulfed ability, the NK cell activity of chicken red blood cell and all do not had obvious influence.Point out this sample to have immunoregulation effect.
Using of composite propolis soft capsule of the present invention: suitable crowd is middle-aged and elderly people, the higher person of blood fat; Oral consumption is secondary every day, each one, and the soft capsule of the present invention of specification 0.5g/ grain.Contain total flavones (in rutin) 6.58g among every 100g, vitamin E 1.01g.
The specific embodiment
Embodiment 1: prepare a kind of composite propolis nutritional solution
The composite propolis nutritional solution, it consists of: propolis extract 170g, Folium Ginkgo extract 80g, vitamin E 4g, Semen Maydis oil 265g.
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo 1600g, and Folium Ginkgo is pulverized, standby;
B. in the Folium Ginkgo of pulverizing, add 50% ethanol 16000g at every turn, under 95 ℃ of conditions, extract and refluxed 1 hour, extract altogether 3 times, merge 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. the filtrate decompression that makes among the c is concentrated into the extractum of (50 ℃ time measure) relative density 1.35, vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder 80g, the extraction ratio of effective component of ginkgo leaf is 5%;
(2) preparation of propolis extract:
A. propolis raw material 425g is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. with the propolis powder for preparing among a, flood three times with each 1700g of 95%, 85%, 75% ethanol successively, dissolved respectively 24 hours, obtain impregnation liquid three times;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, during concentrating under reduced pressure to 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder 170g; The extraction ratio of propolis active ingredient is 40%:
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder 80g, propolis extract powder 170g and vitamin E 4g, Semen Maydis oil 265g are mixed, stir, be heated to 40 ℃;
B. the mixed liquor after the heating among a is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature and promptly make this nutritional solution 519g.
Embodiment 2: prepare a kind of composite propolis nutritional solution
The composite propolis nutritional solution, it consists of: propolis extract 150g, Folium Ginkgo extract 100g, vitamin E 7g, Semen Maydis oil 243g.
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo 2000g, and Folium Ginkgo is pulverized, standby;
B. in the Folium Ginkgo of pulverizing, add 50% ethanol 20000g at every turn, under 95 ℃ of conditions, extract and refluxed 1 hour, extract altogether 3 times, merge 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. the filtrate decompression that makes among the c is concentrated into the extractum of (50 ℃ time measure) relative density 1.35, vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder 100g, the extraction ratio of effective component of ginkgo leaf is 5%;
(2) preparation of propolis extract:
A. propolis raw material 375g is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. the propolis powder for preparing among a is flooded three times with each 1500g of 95%, 85%, 75% ethanol successively, dissolved respectively 24 hours, obtain impregnation liquid three times;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, during concentrating under reduced pressure to 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder 150g, the extraction ratio of propolis active ingredient is 40%;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder 100g, propolis extract powder 150g and vitamin E 7g, Semen Maydis oil 243g are mixed, stir, be heated to 40 ℃;
B. the mixed liquor after the heating among a is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature, make these liquid health care product of 500g;
Embodiment 3:
The preparation of composite propolis nutritional solution, it consists of: propolis extract 130g, Folium Ginkgo extract 120g, vitamin E 9g, Semen Maydis oil 220g.
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo 2400g, and Folium Ginkgo is pulverized, standby;
B. in the Folium Ginkgo of pulverizing, add 50% ethanol 24000g at every turn, under 95 ℃ of conditions, extract and refluxed 1 hour, extract altogether 3 times, merge 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. the filtrate decompression that makes among the c is concentrated into the extractum of (50 ℃ time measure) relative density 1.35, vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder 120g;
(2) preparation of propolis extract:
A. propolis raw material 325g is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. the propolis powder for preparing among a is flooded three times with each 1300g of 95%, 85%, 75% ethanol successively, dissolved respectively 24 hours, obtain impregnation liquid three times;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, during concentrating under reduced pressure to 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder 130g;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder 120g, propolis extract powder 130g and vitamin E 9g, Semen Maydis oil 220g are mixed, stir, be heated to 40 ℃;
B. the mixed liquor after the heating among a is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature, make these health product 479g.
Embodiment 4 preparation of soft capsule:
A. glue preparation: prepare 1000 seed lac softgel shells, take by weighing in gelatin 30g, glycerol 75g, the water 45g inputization glue bucket, water-bath is heated, and dissolving, stirring, evacuation are put into the glue bucket of insulation at last;
B. suppress film, preparation soft capsule: on the soft capsule pellet press, the nutritional solution that makes in the various embodiments described above is filled in the rubber softgel shell of glue preparation, makes 1000 soft capsules, every soft capsule includes nutritional solution 0.5g.
Claims (7)
1. composite propolis nutritional solution, it is characterized in that: it mainly is to be made by the composition of following parts by weight:
130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin Es; 220～270 parts of Semen Maydis oil.
2. composite propolis nutritional solution, it is characterized in that: it mainly is to be made by the composition of following parts by weight:
150 parts of propolis extracts; 100 parts of Folium Ginkgo extract; 7 parts of vitamin Es; 243 parts of Semen Maydis oil.
3. composite propolis soft capsule, it is characterized in that: it mainly is that its composition by following parts by weight is made: wherein capsule 's content composite propolis nutritional solution consists of: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin; 220～270 parts of Semen Maydis oil; Capsule glue shell materials are capsule adjuvant commonly used and preparation according to a conventional method.
4. composite propolis soft capsule, it is characterized in that: its composition by following parts by weight is prepared from: wherein capsule Dissolve things inside composite propolis nutritional solution consists of: 150 parts of propolis extracts; 100 parts of Folium Ginkgo extract; 7 parts of vitamin Es; 243 parts of Semen Maydis oil; Capsule glue shell materials are capsule adjuvant commonly used, and preparation according to a conventional method.
5. according to claim 3 or 4 described composite propolis soft capsules, it is characterized in that: its capsule glue shell materials parts by weight are: 30 parts in gelatin; 75 parts of glycerol; 45 parts in water.
6. the preparation method of a composite propolis nutritional solution, it is characterized in that: it is mainly made by the composition of following portions by weight: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; 5～9 parts of vitamin Es; 220～270 parts of Semen Maydis oil, its preparation method is as follows:
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo by active ingredient extraction ratio 5%, and Folium Ginkgo is pulverized, standby;
B. the 9-12 that presses Folium Ginkgo weight doubly adds 50% ethanol in the Folium Ginkgo of pulverizing, extract under 95 ℃ of conditions and refluxed 1 hour, extracts altogether 3 times, and each ethanol consumption is identical, merges 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
Measure the extractum of relative density 1.35, vacuum 0.08Mpa when d. the filtrate decompression that makes among the c being concentrated into 50 ℃;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder, the extraction ratio of Folium Ginkgo active ingredient is 5%;
(2) preparation of propolis extract:
A. take by weighing propolis raw material by active ingredient extraction ratio 40%, and propolis raw material is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. with the propolis powder for preparing among a successively with 95%, 85%, 75% alcohol dipping of 3-6 times of propolis raw material weight three times, each ethanol consumption is identical, dissolves respectively 24 hours, obtains impregnation liquid three times;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, during concentrating under reduced pressure to 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder, the extraction ratio of effective bee glue components is 40%;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder, propolis extract powder and vitamin E, Semen Maydis oil are mixed in proportion, stir, be heated to 40 ℃;
B. the mixed liquor after the heating in (3) is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature.
7. the preparation method of a composite propolis soft capsule, it is characterized in that: it is prepared from by the composition of following portions by weight: 130～170 parts of propolis extracts; 80～120 parts of Folium Ginkgo extract; Vitamin E 5-9 part; 220～270 parts of Semen Maydis oil; 30 parts in gelatin; 75 parts of glycerol; 45 parts in water, its preparation method comprises:
(1) preparation of Folium Ginkgo extract:
A. take by weighing Folium Ginkgo by active ingredient extraction ratio 5%, and Folium Ginkgo is pulverized, standby;
B. the 9-12 that at every turn presses Folium Ginkgo weight doubly adds 50% ethanol in the Folium Ginkgo of pulverizing, extract under 95 ℃ of conditions and refluxed 1 hour, extracts altogether 3 times, and each ethanol consumption is identical, merges 3 times extracting solution;
C. the extracting solution that makes among the b is filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
Measure the extractum of relative density 1.35, vacuum 0.08Mpa when d. the filtrate decompression that makes among the c being concentrated into 50 ℃;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 3-4 days under 70 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make Folium Ginkgo extract Folium Ginkgo extract powder, the extraction ratio of Folium Ginkgo active ingredient is 5%;
(2) preparation of propolis extract:
A. take by weighing propolis raw material by active ingredient extraction ratio 40%, and propolis raw material is pulverized under-4 ℃ of conditions, cross 100 mesh sieves, standby;
B. with the propolis powder for preparing among a, use 95%, 85%, 75% alcohol dipping three times of 3～6 times of propolis raw material weight successively, each ethanol consumption is identical, dissolves respectively 24 hours, obtains impregnation liquid three times;
C. three impregnation liquid among the b are all filtered with rotating speed 3000rpm, 400 purpose tripodia frame centrifuges;
D. three filtrates that make among the c are merged, during concentrating under reduced pressure to 50 ℃ relative density be 1.35, the extractum of vacuum 0.08Mpa;
E. with the extractum drying under reduced pressure vacuum 0.08Mpa that makes among the d, baking is 2 days under 50 ℃ of conditions, and system gets dry extract;
F. the dried cream powder that makes among the e is broken, cross 100 mesh sieves, make propolis extract propolis extract powder, the extraction ratio of effective bee glue components is 40%;
(3) preparation of nutritional solution:
A. ginkgo biloba extract powder, propolis extract powder and vitamin E, Semen Maydis oil are mixed in proportion, stir, be heated to 40 ℃;
B. the mixed liquor after the heating among a is passed through colloid mill 2-3 time, and take out bubble, drop to room temperature;
(4) preparation of soft capsule:
A. glue preparation: in gelatin, glycerol, water input glue bucket, water-bath is heated, is dissolved, stirring, evacuation, puts into the glue bucket of insulation at last;
B. suppress film, preparation soft capsule: on the soft capsule pellet press, the nutritional solution that makes in (3) is circulated in the rubber softgel shell of glue preparation, makes soft capsule.
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| CN100340250C (en) * | 2005-06-09 | 2007-10-03 | 周云川 | Composite propolis soft capsule |
| CN101843308B (en) * | 2010-06-07 | 2012-12-12 | 杭州天厨蜜源保健品有限公司 | Propolis soft capsule and preparation method thereof |
| CN102552732B (en) * | 2012-02-23 | 2013-08-14 | 山东金硕生物科技股份有限公司 | Chinese medicinal preparation or Chinese medicinal health care product with effect of reducing blood fat |
| CN102726643A (en) * | 2012-07-11 | 2012-10-17 | 李效铭 | Formula of propolis, grape pip and folium ginkgo compound preparation with function of reducing blood fat |
| CN103190621B (en) * | 2013-04-03 | 2015-05-27 | 上海春芝堂生物制品有限公司 | Propolis soft capsule and preparation method thereof |
| CN104958345A (en) * | 2015-07-14 | 2015-10-07 | 陈雨 | Soybean lecithin soft capsule with lipid-reducing function and preparation method thereof |
| CN109785516A (en) * | 2017-11-13 | 2019-05-21 | 王建忠 | A kind of site intelligent production selling system of more category fresh foods |
| CN108813499A (en) * | 2018-07-09 | 2018-11-16 | 武汉康思农生物科技有限公司 | A kind of bee glue soft capsule formula and preparation process |
| CN109700011A (en) * | 2019-01-23 | 2019-05-03 | 王鸿雁 | A kind of health food and preparation method thereof improving sleep |
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