CN1250661A - Medicinal composition for treating bone fracture and its preparing process - Google Patents

Abstract

This invention medicinal composition is made up by using coral, abalone shell, ochre, cucumber seed, eucommia bark, calamine, pyrite, gypsum, frankincense, myrrh, dalbergia wood, pilose asiabell root, Chinese angelica root, hydrophite, silver pearl, safflower and musk through decoction according to certain proportion, and is mainly used for curing new and old fractures, distocation of bone, disconnected bone, deficiency in calcium, injury of muscle, tendon and ligament and othen injuries of soft tissue with short curing period.

Description

A kind of pharmaceutical composition and preparation method for the treatment of fracture

The present invention relates to treat the medicine and the preparation technology of orthopaedic disease, exactly is to disclose a kind of pharmaceutical composition and preparation method for the treatment of fracture, belongs to the Mongolia patent drug medicine technology field.

Medicine for bone disease has a lot, loose as Radix Notoginseng Tabellae, Flos Carthami etc., its therapeutic effect also is sure, but treatment cycle, medical expense and user's rule have difference greatly, conventional bone injury drug price compares higher, treatment cycle is long, is 49 days as " Radix Notoginseng Tabellae " for the The average healing of fracturing, and promotes that the union of fracture rate is 87%; The medicine that has also needs therefore, to have influenced the treatment of patient with bone fracture with the yellow wine clothes down, has prolonged treatment time, has increased patient's burden.

The objective of the invention is to disclose a kind of pharmaceutical composition for the treatment of fracture, shorten treatment cycle, reduce medical expense, improve therapeutic effect, simplify Therapeutic Method.

Another object of the present invention provides the preparation of drug combination method of treatment fracture.

To achieve the object of the present invention, concrete solution is based on understanding and the Therapeutic Principle of traditional Mongolian medicine to the morbidity base reason of bone disease, and with reference to the modern pharmacy achievement in research, crude drugs such as selected Corallium Japonicum Kishinouye, Concha Haliotidis are concocted through special process, make pharmaceutical composition; )

Medicine of the present invention is made (by ratio of weight and the number of copies) by following component:

Corallium Japonicum Kishinouye 6～10 Concha Haliotidis 6～10 Haematitums 6～10 Semen Cucumidis sativi 6～10

The Cortex Eucommiae 6～10 Calaminas 6～10 Pyritums 6～10 Gypsum Fibrosum 6～10

Olibanum 6～10 Myrrhas 6～10 Lignum Dalbergiae Odoriferaes 6～10 Radix Salviae Miltiorrhizaes 6～10

Radix Angelicae Sinensis 6～10 Mirabilitum crystallinas 6～10 Vermilion 3～5 Stigma Crocis 1～4

Moschus 0.005～0.008

The medicine of above-mentioned each component is taken by weighing in proportion, and concocts by the following method:

Corallium Japonicum Kishinouye: pulverize the back and add in the fresh milk and soak more than 6 hours, and heated and boiled 1～2 hour, it is stand-by to take out the back pulverize;

Mirabilitum crystallina: Mirabilitum crystallina is forged, be ground into fine powder, become reconciled into sticking bulk, dry in the shade with fresh milk;

Calamina: the earthenware of putting into sealing is forged, and puts into water after grinding, and the rinsing precipitation is got fine flour.

Haematitum: with vinegar forge quench after, smash porphyrize to pieces.

Concha Haliotidis: put into fresh milk after the grinding and spent the night at least 6 hours, boiled 1～2 hour, take out porphyrize.

Pyritum: forge with vinegar and to quench, be ground into fine powder.

Gypsum Fibrosum: place refractory container, put into stove fire and forge, taking-up is put into yoghourt immediately and is quenched, and takes out airing, smashs porphyrize to pieces.

Other single medicine Semen Cucumidis sativi, the Cortex Eucommiae, Olibanum, Myrrha, Lignum Dalbergiae Odoriferae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Vermilion, Stigma Croci, Moschus are pulverized with above-mentioned each medicament mixed after clean system and are evenly promptly made medicine.

This pharmaceutical composition can be made into various pharmaceutical dosage forms such as powder, watered pill, slow releasing capsule, tablet.

Corallium Japonicum Kishinouye, Concha Haliotidis, Haematitum, Cortex Eucommiae medicine sweet in the mouth, hardship are cool in nature and cold in the present invention, have the function of heat-clearing and toxic substances removing, and activating blood circulation to dissipate blood stasis, kidney tonifying synthetism, dry " Xieri Wusu Symptom " play a major role in the prescription; Myrrha, Pyritum, Gypsum Fibrosum, Semen Cucumidis sativi, Stigma Croci bitter in the mouth are and sweet, and property is flat, are suitable for that treatment is got mildewed in warm conditions, tendon and vessel injury, traumatic pain, fracture, edema, wound hemorrhage, use as accessory drugs; Olibanum, Lignum Dalbergiae Odoriferae, Moschus acrid in the mouth and hardship is warm in nature, greasy for controlling " He Yire ", the heart " conspicuous according to ", " conspicuous according to " headache, liver, nephropathy, are adjuvant drug; Mirabilitum crystallina, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Vermilion acrid in the mouth, sweet, property is rough, controls that dyspepsia, heat in the heart, wound do not heal, hepatosplenomegaly, " conspicuous according to " disease, is messenger drug.

This drug main will be used for the treatment of new and old fracture, dislocation, bone does not connect, ischemic necrosis of femoral head, useless in orthopaedic diseases such as property decalcification, muscle, flesh muscle, ligament injury, meniscus and soft tissue injurys.

Instructions of taking: 4～6 grams/time, day clothes secondary, eliminating cold for resuscitation water clothes are down.

Good effect of the present invention is: have no side effect, compare with similar medicine, the treatment cost is low, and healing time shortens, and has expanded set a broken bone and has been suitable for the disease scope.

The present invention is through the clinical observation of 120 routine systems, and does matched group with similar medicine " Radix Notoginseng Tabellae ", is basis with " Bollinger body Mongolian medicine's osteopethy handed down from one's ancestors " (96 years versions of a distant place, Inner Mongol publishing house) union of fracture standard and criterion of therapeutical effect, and it is as follows to compare the result:

120 routine typical case history statistics

120 routine typical case history medication efficacy analysis

Compare with the medical expenses of similar medicine:

	Healing time/sky	Average one day medical expense/unit	Whole medical expense/unit
				Radix Notoginseng Tabellae	????49.30	????38.94	????1919.74
Medicine of the present invention	????27.15	????42.70	????1159.31

Further specify the present invention below in conjunction with embodiment:

Embodiment 1

Take by weighing raw material by following proportioning:

Corallium Japonicum Kishinouye 6kg Concha Haliotidis 6kg Haematitum 6kg Semen Cucumidis sativi 6kg

Cortex Eucommiae 6kg Calamina 6kg Pyritum 6kg Gypsum Fibrosum 6kg

Olibanum 6kg Myrrha 6kg Lignum Dalbergiae Odoriferae 6kg Radix Salviae Miltiorrhizae 6kg

Radix Angelicae Sinensis 6kg Mirabilitum crystallina 6kg Vermilion 3kg Stigma Croci 1kg

Moschus 6g

To soak 8 hours in the Corallium Japonicum Kishinouye pulverizing back adding fresh milk, and heat and boiled 2 hours, taking-up back pulverize is stand-by;

Mirabilitum crystallina: Mirabilitum crystallina forged be ground into fine powder, become reconciled with becoming to glue bulk and dry in the shade with 2 times of volume fresh milks;

Calamina: the earthenware of putting into sealing is forged, and puts into water after grinding, and the rinsing precipitation is got fine flour;

Haematitum: with vinegar forge quench after, smash to pieces, be ground into fine powder;

Concha Haliotidis: put into fresh milk after the grinding and spend the night and boil 1～2 hour, take out porphyrize;

Pyritum: forge with vinegar and to quench, be ground into fine powder;

Gypsum Fibrosum: place refractory container, put into stove fire and forge to being popular in, taking-up is put into special yoghourt immediately and is quenched, and takes out airing, smashs to pieces along thin;

Other single medicine Semen Cucumidis sativi, the Cortex Eucommiae, Olibanum, Myrrha, Lignum Dalbergiae Odoriferae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Vermilion, Stigma Croci, Moschus are pulverized with above-mentioned each medicament mixed after clean system and are evenly promptly made powdered medicine, and this medicine is a light brown powder, feeble QI perfume (or spice), bitter in the mouth.Oral, one time 4～6 gram, 2 times on the one.

Claims (3)

1, a kind of pharmaceutical composition for the treatment of fracture, by following medicine by weight mark than forming:

Corallium Japonicum Kishinouye 6～10 Concha Haliotidis 6～10 Haematitums 6～10 Semen Cucumidis sativi 6～10

The Cortex Eucommiae 6～10 Calaminas 6～10 Pyritums 6～10 Gypsum Fibrosum 6～10

Olibanum 6～10 Myrrhas 6～10 Lignum Dalbergiae Odoriferaes 6～10 Radix Salviae Miltiorrhizaes 6～10

Radix Angelicae Sinensis 6～10 Mirabilitum crystallinas 6～10 Vermilion 3～5 Stigma Crocis 1～4

Moschus 0.006～0.008

2, the preparation method of aforementioned pharmaceutical compositions, realize by following technology:

The medicine of above-mentioned each component is taken by weighing in proportion, and concocts by the following method:

Corallium Japonicum Kishinouye: pulverize in the back adding fresh milk and soak more than 6 hours, and heat and boiled 1～2 hour, it is stand-by to take out the back pulverize;

Mirabilitum crystallina: Mirabilitum crystallina forged be ground into fine powder, become reconciled with fresh milk and dry in the shade;

Calamina: the earthenware of putting into sealing is forged, and puts into water after grinding, and the rinsing precipitation is got fine flour;

Haematitum: with vinegar forge quench after, smash to pieces and be ground into fine powder;

Concha Haliotidis: put into fresh milk after the grinding and spend the night and boil 1～2 hour, take out porphyrize;

Pyritum: forge with vinegar and to quench, be ground into fine powder;

Gypsum Fibrosum: place refractory container, put into stove fire and forge to being popular in, taking-up is put into special yoghourt immediately and is quenched, and takes out airing, smashs to pieces along thin;

Other single medicine Semen Cucumidis sativi, the Cortex Eucommiae, Olibanum, Myrrha, Lignum Dalbergiae Odoriferae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Vermilion, Stigma Croci, Moschus are pulverized with above-mentioned each medicament mixed after clean system and are evenly promptly made medicine.

3,, can be made into various pharmaceutical dosage forms such as powder, watered pill, slow releasing capsule, tablet according to the pharmaceutical composition of claim 1.