CN113598763A - Non-invasive blood glucose detection device and method based on MIC-PCA-NARX correction algorithm - Google Patents
Non-invasive blood glucose detection device and method based on MIC-PCA-NARX correction algorithm Download PDFInfo
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Abstract
The invention relates to a non-invasive blood glucose detection device and method based on an MIC-PCA-NARX correction algorithm, and belongs to the technical field of biomedical signal acquisition and processing. The device comprises a signal conditioning circuit, a data storage module, a transmission module, a light source driving circuit, a constant temperature control module, a probe board, an MCU, a power supply module and a display module; the probe plate integrates four light sources and a photoelectric receiver; the MCU controls the equipment to operate, transmit and store data and the blood sugar value calculated by a blood sugar prediction model based on an MIC-PCA-NARX correction algorithm according to the input information of the user.
Description
Technical Field
The invention belongs to the technical field of biomedical signal acquisition and processing, and relates to a non-invasive blood glucose detection device and method based on MIC-PCA-NARX correction algorithm.
Background
At present, the detection of blood sugar concentration is mainly carried out by adopting an automatic biochemical analyzer detection method and a rapid glucometer detection method. The automatic biochemical analyzer detection method comprises the steps of collecting a blood sample in a venous blood collection mode, then carrying out centrifugal treatment on the collected blood sample to obtain serum, and analyzing the serum by using a biochemical analyzer to obtain a blood glucose concentration value of a tested person. The blood glucose concentration result measured by the automatic biochemical analyzer is higher in accuracy, but the blood sample demand is larger, the detection time is longer, the volume of the biochemical instrument for detection is larger, and the like, so that the blood glucose concentration detection method is generally only applied to places such as hospitals. The rapid glucometer measurement method adopts a mode of pricking fingertips to collect blood, generally collects about 1-3 mu L of blood sample, sucks the blood sample through the siphoning action of disposable test paper, and can calculate a blood glucose concentration measurement value by a miniature glucometer in a short time. The rapid glucometer on the market at present generally has the advantages of high measuring speed, simple operation steps, small size and convenience in carrying, so that the rapid glucometer is widely applied to daily blood glucose detection of diabetics.
Whether blood is taken from veins or finger tips by needle pricks belong to invasive measurement modes. Frequent measurement of blood glucose concentration inevitably causes pain and even psychological trauma to the patient, and may cause infection if mishandled. In addition, disposable test paper matched with the rapid glucometer measurement method is a small medical expense, and forms a large economic burden for families of patients.
Therefore, the research of the non-invasive blood sugar is very important, the detection of the non-invasive blood sugar can provide humanized and risk-free detection service for a subject, can help a diabetic patient to effectively prevent and control diabetes and complications thereof, and avoids the influence of the blood sugar detection on the life quality of the diabetic patient and the resistance generated by long-term detection.
Among many noninvasive blood sugar detection methods, the near-infrared detection method is the most widely applied detection method by virtue of its simple equipment and cost advantages, and when detecting blood sugar by using near-infrared light, temperature is an important influence factor which is not negligible, and the temperature mainly changes the vibration spectrum of molecules by changing the acting force among molecules, and in the spectrum of water, the temperature can affect O-H stretching vibration and frequency multiplication thereof: as the temperature increases, the O-H frequency band shifts to a lower wavelength and becomes sharper, and under quantitative research of researchers, it is found that near infrared light absorption caused by a temperature change of 0.1 ℃ is approximately equal to a change of 1mmol/L glucose concentration, and the temperature change of the measured part also affects the optical characteristic parameters of the tissue. Researchers have prepared samples of abdominal skin,the reflection and transmission energy of the sample is measured by an integrating sphere device, and the optical characteristic parameters are calculated by adopting an inverse Monte-Carlo algorithm. The results show that the scattering coefficient (u 'is optimized at different wavelengths for dermal tissue's) The tissue absorption coefficient (u) increases with increasing temperatureα) There was no significant change. Researchers have also studied the near infrared wavelength function relationship between temperature and optical parameters of human dermis and subcutaneous tissue in the temperature range of 25-40 ℃. The results of a study of a total of 9 ex vivo skin samples from the abdomen of 3 different human bodies showed that temperature was u 'of the dermis and the subcutaneous tissue'sThe effect of (c) is reproducible. U 'of subcutaneous tissue with increasing temperature'sReduced and dermal u'sWill gradually increase without the absorption spectrum having a fixed trend of change with temperature. In addition, tissues with higher protein content exhibit a positive temperature coefficient, while tissues with higher body fluid content exhibit a negative temperature coefficient. Temperature is therefore a non-negligible factor for near infrared detection of blood glucose.
At present, the existing noninvasive glucose meters in China are mainly designed based on the principle of a thermometabolism method, for example, the noninvasive glucose meters developed by Bobong Fangzhou have good detection values in a hyperglycemia area, but cannot be used as clinical medication guidance at present.
In recent years, more and more scientific researchers are researching and developing noninvasive blood glucose detection at home and abroad, but in terms of the current domestic situation, the temperature factor is not eliminated by blood glucose equipment based on near infrared light, only the temperature influence is considered in the algorithm, but the temperature has a complex nonlinear influence on the absorbance of the near infrared light, the temperature influence cannot be well eliminated by the algorithm, in addition, mature and reliable noninvasive blood glucose equipment is still scarce, the purchase price of the foreign noninvasive blood glucose equipment is expensive, the maturity of the foreign noninvasive blood glucose equipment is still short, and the popularization rate in China is extremely low. Such as: the near-infrared-light-based noninvasive blood glucose monitor is developed by the national Israel CONGA company, 4 monochromatic light sources in the range from visible light to near-infrared light (about 600-1000 nm) are adopted in the noninvasive blood glucose monitor, and a color image sensor detects residual light signals after the residual light signals pass through fingers. Compared with invasive blood sugar measuring equipment, the noninvasive blood sugar measuring instrument has good correlation, but the invasive blood sugar measuring instrument needs to be trained by acquiring invasive blood sugar measuring values of 50-60 times in a week or a month for a patient before the instrument is used, and then accurate noninvasive blood sugar values of the corresponding patient can be predicted.
Therefore, there is a need for a non-invasive blood glucose detecting device that can improve the detection accuracy and reduce the equipment cost.
Disclosure of Invention
In view of the above, the present invention provides a non-invasive blood glucose detecting apparatus and method based on MIC-PCA-NARX correction algorithm, which can improve stability and accuracy of non-invasive blood glucose detection and reduce equipment cost.
In order to achieve the purpose, the invention provides the following technical scheme:
a non-invasive blood glucose detection device based on MIC-PCA-NARX correction algorithm comprises a signal conditioning circuit, a data storage module, a transmission module, a light source driving circuit, a constant temperature control module, a probe board and an MCU;
the probe plate integrates four light sources and a photoelectric receiver and is used for detecting a detected medium;
the light source driving circuit is connected with four light source positions of the probe plate, the constant temperature control module is connected with the probe plate, the output end of the probe plate is connected with the signal conditioning circuit, the output end of the signal conditioning circuit is connected with an A/D interface of the MCU, and the data storage module and the transmission module are connected with an I/O port of the MCU;
the light source driving circuit is used for providing working current for the four light sources;
the constant temperature control module is used for controlling the constant temperature of the finger contact area of the user during detection;
the MCU is used for receiving user input information, controlling the equipment to operate, transmitting and storing data and blood sugar values calculated by a blood sugar prediction model based on an MIC-PCA-NARX correction algorithm, wherein the MIC-PCA represents a maximum information coefficient principal component analysis method, and the NARX represents a time sequence;
the data storage module and the transmission module are respectively used for storing and sending the blood sugar detection result of the user.
Furthermore, the device also comprises a display module and a power supply module;
the display module is connected with an I/O port of the MCU, is used for providing a human-computer interaction interface, is used for inputting user information (such as parameters of height, weight, systolic pressure, diastolic pressure and the like, and is used as input information of the blood sugar prediction model to obtain a blood sugar noninvasive detection value), displays a blood sugar detection result of a user and historical blood sugar information (such as a blood sugar value change curve), controls the operation of equipment and the like.
The power supply module is connected with the signal conditioning circuit, the MCU, the light source driving circuit, the display module, the constant temperature control module, the data storage module and the transmission module and supplies power to the modules. Specifically, the power module provides 5V voltage for the display module, 5V and 3.3V voltage for the signal conditioning circuit, 3.3V and 1.5V voltage for the light source driving circuit, 3.3V voltage for the data storage module and the transmission module, 3.3V voltage for the MCU, and 5V voltage for the constant temperature control module.
Further, the light source driving circuit specifically includes: the light source driving circuit takes the light source driving chip as a core, and the light source temperature control circuit takes the temperature control chip as a core; the light source adopts a current control driving mode, in order to ensure the stability of control current, a driving chip is adopted to output current, and the chip activation mode is a low-level effective triode control circuit; the light source is turned on/off by adopting four I/O ports controlled by a singlechip to output high and low levels to control whether a triode is conducted or not and control whether a driving chip of the light source outputs current or not, thereby controlling the time-sharing lighting of the light sources with 4 wavelengths.
Further, the signal conditioning circuit specifically includes: the current-to-voltage circuit, the filter circuit and the main amplifying circuit; the input end of the current-to-voltage circuit is connected with the output end of the photoelectric receiver of the probe plate, the input end of the filter circuit is connected with the output end of the current-to-voltage circuit, and the input end of the main amplification circuit is connected with the output end of the filter circuit.
Further, the constant-temperature control module comprises a thermistor sensor, a triode switch circuit, a heating sheet and a voltage division circuit, and is used for detecting the temperature of the finger contact area of the user; when a temperature rise instruction is input into the display module, the MCU acquires the voltage of the thermistor in the voltage division circuit, calculates the current temperature of the finger contact area through the voltage-temperature function of the thermistor, and outputs a high level to switch on the triode control circuit and the heating sheet to work if the temperature is lower than 35 ℃; otherwise, the MCU outputs a low level to cut off the triode control circuit, and the circuit is disconnected to wait for cooling; the constant temperature control module is used for eliminating the influence of temperature on near infrared light absorption; because the near infrared light absorption caused by the temperature change of 0.1 ℃ is equal to the glucose concentration change of 1mmol/L, the temperature of the finger joint area of the detection chamber is controlled to be constant, and the influence of the temperature on the near infrared light absorption is eliminated.
Furthermore, four integrated light sources on the probe plate surround the photoelectric receiver, the distance between any one light source and the center of the photoelectric receiver is set to be 3.8-4.5 mm, and the distance between every two light sources is 6-7 mm.
Further, the four light sources include: 1 light source at 1310nm band of 1000-.
Further, the blood glucose prediction model based on the MIC-PCA-NARX correction algorithm comprises: the influence of other physiological parameters of a human body is considered, environmental humidity, systolic pressure, diastolic pressure, pulse rate, age, waist circumference and BMI index are introduced to serve as the influence factors of the precision of the blood glucose noninvasive prediction model, the MIC-PCA method is used for reducing the dimension of input variables, and the trained blood glucose prediction model is input to calculate the blood glucose value by combining diffuse reflection signals of human tissue components corresponding to four kinds of wavelength near infrared light detected in a constant temperature detection area.
Further, the blood glucose prediction model based on the MIC-PCA-NARX correction algorithm further comprises: taking the blood glucose absorbance characterization value R as an input variable and the input variable subjected to MIC-PCA dimensionality reduction as the input of a subsequent NARX model;
the calculation formula of the blood glucose absorbance characterization value R is as follows:
R＝(λ1+λ2)/2-(λ3+λ4)/2
wherein λ is1，λ2Corresponding to the absorbance characterization value, lambda, of blood sugar of the main absorption component of 2 light sources with different wavelengths in the range of 1500-plus 1800nm for human body3，λ4The absorbance average value of the main absorption components of the light source in the ranges of 1350-1430nm and 1000-1310nm corresponding to human tissues.
The invention has the beneficial effects that:
1) the invention designs a non-invasive detection device for human finger tissue blood sugar by utilizing the difference of the blood sugar and other tissue components in a human body on the absorbance of near infrared light, the device does not cause harm to the human body, and the interference of most tissue components can be removed by detecting the near infrared light with 4 wavelengths, so that the blood sugar value with better accuracy and higher prediction precision can be obtained.
2) Aiming at the influence of temperature on the absorption of near infrared light, the invention provides that the temperature of a blood sugar detection area is kept constant, a constant temperature control module is added, the change of the ambient temperature is determined by a heating sheet, a temperature detection sensor (thermistor) detects the ambient temperature once every 0.2s and converts the ambient temperature into an electric signal, an MCU (microprogrammed control unit) acquires the voltage value through AD (analog-to-digital) and compares the voltage value with a voltage value corresponding to the preset temperature, if the voltage value is lower than the preset temperature, a singlechip is conducted with a triode switching circuit, the heating sheet starts to work and the ambient temperature is increased, so that the temperature of the detection area is controlled to be constant, and the influence of different temperatures on the detection result is eliminated.
3) The blood sugar noninvasive detection method has the advantages that the detection area of the method selects a human finger area, capillaries are rich, the epidermal layer is thin, near infrared light can better penetrate through the epidermal layer to enter the dermal layer, so that the obtained signals contain more useful information, the detection result is higher due to the fact that the single wavelength sensitive to glucose is used for detection, and the other tissue components of the human body, such as water, protein and the like, can absorb the wavelength at a small part, so that the influence of the components of the water, the protein and the like in the human tissue needs to be considered, and the absorption condition of 1310nm and 1430nm is used as the representation of interference signals of the components of the water, the protein and the like in the human tissue; in order to reduce accidental errors of single-wavelength detection of glucose, two detection wavelengths are selected to detect glucose signals in the capillary in the 1500-1800nm waveband; the signal content that 4 wavelengths were gathered is abundanter, and accidental error is littleer, and convenient processing obtains the blood sugar signal that the SNR is high, reduces the condition of mistake appearing, and then seeks the blood sugar detection value who gets rid of human tissue interfering signal for blood sugar does not have blood sugar and does not have blood sugar detection value stability better, monitoring accuracy is higher.
4) The blood sugar noninvasive detection device preferably adopts the integrated design of a lower computer end and a human-computer interaction end, so that the blood sugar noninvasive detection device can be designed based on an embedded technology, can form an independent miniaturized device, and has the advantages of portability, good flexibility, low cost, convenience in popularization and strong adaptability.
5) The near-infrared light diffuse reflection portable blood sugar noninvasive detection device based on the MIC-PCA-NARX correction algorithm takes the environmental humidity, the systolic pressure, the diastolic pressure, the pulse rate, the age, the waist circumference, the BMI index and the blood sugar near-infrared diffuse reflection absorbance as independent variables, and fully considers the influence of environmental factors and human physiological factors on the near-infrared light diffuse reflection-based blood sugar noninvasive detection.
6) The device of the invention enables the in-vivo non-invasive detection of the blood sugar of the human body to be possible, has the advantages of small volume, constant temperature control of the detection area, portability and non-invasive detection, and is more convenient for daily detection and long-term monitoring compared with the conventional quick glucometer; in addition, the device has the advantages of flexible detection system, convenient system upgrade and low long-term use cost, and is suitable for household long-term blood sugar detection.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention may be realized and attained by the means of the instrumentalities and combinations particularly pointed out hereinafter.
Drawings
For the purposes of promoting a better understanding of the objects, aspects and advantages of the invention, reference will now be made to the following detailed description taken in conjunction with the accompanying drawings in which:
FIG. 1 is a system block diagram of a non-invasive blood glucose detecting device according to the present invention;
fig. 2 is a schematic diagram of a probe board in the non-invasive blood glucose detecting device.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It should be noted that the drawings provided in the following embodiments are only for illustrating the basic idea of the present invention in a schematic way, and the features in the following embodiments and examples may be combined with each other without conflict.
Wherein the showings are for the purpose of illustrating the invention only and not for the purpose of limiting the same, and in which there is shown by way of illustration only and not in the drawings in which there is no intention to limit the invention thereto; to better illustrate the embodiments of the present invention, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by terms such as "upper", "lower", "left", "right", "front", "rear", etc., based on the orientation or positional relationship shown in the drawings, it is only for convenience of description and simplification of description, but it is not an indication or suggestion that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes, and are not to be construed as limiting the present invention, and the specific meaning of the terms may be understood by those skilled in the art according to specific situations.
Referring to fig. 1-2, the present invention provides a non-invasive blood glucose measuring device, wherein the selected measuring part of the device is the finger tip, and the human finger has abundant capillaries, long-term exposure to the outside, convenient sampling and measurement, and optimal measurement effect. The influence of temperature on near infrared light is considered, and the detection area is subjected to constant temperature control; the interference signals generated in the process of detecting the blood sugar of the fingertip of a human body by utilizing the near infrared light mainly come from other components in the tissues of the human body such as: moisture, protein, fat and the like, which slightly absorb near infrared light with the detection wavelength of 1500-. Therefore, the interference of other tissue components of human body such as water, protein and fat needs to be detected by using near infrared light with the wavelength ranges of 1000-1310nm and 1310-1430 nm.
Based on the detection device, the invention designs a noninvasive blood glucose detection method based on an MIC-PCA-NARX correction algorithm, aims to keep the temperature in a detection area constant through the difference of the absorption degree of human tissues to near infrared light, realizes the blood glucose detection of a user by using a noninvasive blood glucose meter, and provides a new solution for the noninvasive detection of blood glucose.
The blood sugar non-invasive detection method provided by the invention takes the fingertip of a human body as a non-invasive detection area of blood sugar, keeps the temperature of the detection area constant, takes the absorption condition of the fingertip area to near infrared light with wave bands of 1000-.
The implementation process of the blood sugar noninvasive detection method mainly comprises the following steps:
1) and opening the detector, and inputting the ambient humidity, the systolic pressure, the diastolic pressure, the pulse rate, the age, the waist circumference and the BMI index as input variables of a subsequent model.
2) After the step 1) is finished, clicking a detection button on the serial port screen, enabling the glucometer to start working, after the temperature control module controls the temperature in the detection area to be at a set temperature, putting a finger into the detection port, clicking a determination button for waiting for 40s to obtain 4 wavelengths of diffuse reflection light, pre-amplifying and conditioning the 4 wavelengths of diffuse reflection light, and then carrying out analog-to-digital conversion on the light intensity signal by using a microcontroller.
3) The invention provides a blood sugar prediction model based on MIC-PCA-NARX correction algorithm, which is established by utilizing a plurality of parameters obtained in the steps 1) and 2) to realize a noninvasive blood sugar prediction model, and the specific realization process is as follows:
performing dimensionality reduction on input data by using a principal component analysis method of an MIC-PCA maximum information coefficient to obtain the input of a subsequent NARX model;
constructing a network structure of a NARX model based on a microcontroller platform according to a formula Nhid＝2Nin+1 determining the number of hidden layer neurons, where Nin、NhidRespectively representing the number of neurons of an input layer and a hidden layer;
the NARX model not only has the simulation function of a time sequence, but also can well depict the nonlinear relation, so that the NARX model can have a better prediction function on the non-stable and nonlinear time sequence. The NARX model is defined as follows:
y(t)＝f[y(t-1)，y(t-2)，...，y(t-ny)，x(t-1)，x(t-2)，...，x(t-nd)]
wherein, y (t-1), y (t-2),.. and y (t-n)y) Is the past output time series, x (t-1), x (t-2)d) Representing a multidimensional input time series, and the mapping f (-) represents a non-linear process.
Particularly, in the present embodiment, the specific technical design points of the non-invasive blood glucose detecting apparatus are mainly divided into the following parts:
1) the specific structural design and wavelength of the blood glucose information acquisition probe plate are combined with the position of the photoelectric receiver;
2) controlling the temperature of the detection area to be constant;
3) the light source driving module is used for realizing driving and control of different near infrared light sources;
4) the signal preprocessing circuit is used for preprocessing the blood sugar signal;
5) the serial port screen inputs personal parameters of a user, and finally displays a blood glucose calculation value of the user, and in addition, blood glucose value data can be transmitted to the smart phone application for displaying, analyzing and storing through the expanded wireless transmission function of the device.
The following is a detailed description of each section.
As a specific preferred design, in this embodiment, each sub-module of the blood glucose detecting apparatus employs unified power supply, and then employs a corresponding regulated power supply module according to the working voltage required by each module to provide a rated working voltage for each module.
In this embodiment, the blood glucose information collecting probe plate is used for attaching to a finger tip, and detects the intensity of the emergent light of the infrared light reflected by the finger tip irradiated by the 1000-. The specific light source arrangement and PD position are shown in fig. 2, four light sources (i) integrated on the probe board surround the photoelectric receiver (ii), the central distance between any one light source and the photoelectric receiver is set to be L2-4 mm, and the central distance between two light sources is set to be L1-6.35 mm.
In this embodiment, the blood glucose noninvasive detection device includes a signal conditioning circuit, a power module, a light source driving circuit, a display module, a constant temperature control module, a data storage module, a transmission module, and a probe board. The signal conditioning circuit is used for conditioning reflected light containing human body physiological information and comprises a current-to-voltage amplifying circuit and a filter circuit main amplifying circuit. The power module mainly provides power for the equipment. The light source driving circuit comprises a light source driving current circuit taking a light source driving chip as a core and a light source temperature control circuit taking a temperature control chip as a core; the display module is used for inputting user information, displaying a user blood sugar measurement value and controlling the operation of equipment; the constant temperature control module is used for controlling the constant temperature in a narrow space for placing fingers, comprises a heating circuit and a temperature detection circuit and is used for eliminating the influence of different temperatures on near infrared light absorption. The data storage module and the transmission module are used for storing and transmitting the blood sugar detected by the user. The probe board module integrates 4-wavelength light sources and PD receivers as the detection front end of the human tissue optical information.
Therefore, an independent miniaturization device can be formed, and the device has the advantages of portability, good flexibility, low cost, convenience in popularization and strong adaptability.
Whether the detection device works or not is controlled by issuing an instruction through the serial port screen, user information, namely environment humidity, systolic pressure, diastolic pressure and the like, is input on the serial port screen, after the detection is finished, a detection button is clicked, a program operation instruction is issued through the serial port screen, the equipment starts to work, firstly, a constant temperature control module operates, a change heating sheet of the environment temperature determines, a temperature detection sensor (thermistor) detects the environment temperature once every 0.2s and converts the environment temperature into an electric signal, an MCU (microprogrammed control unit) collects the voltage value through AD (analog-to-digital) and compares the voltage value corresponding to the preset temperature, if the temperature is lower than the set temperature, a singlechip switches on a triode switch circuit, the heating sheet starts to work, and the environment temperature is increased so as to control the temperature of a detection area to be constant; and after the temperature reaches the set temperature, independently lightening 4 near infrared lights in the probe plate in a time-sharing manner. The on-off of the light sources with the 4 wavelengths is controlled by the light source driving module, and the low level is output through an I/O pin of the microcontroller, so that the triode circuit is conducted, the light source control chip works, and the constant current is output to drive the light sources to work. The light sources sequentially emit light, incident light penetrates through the epidermis layer of the fingertip of the human body to reach the dermis layer, is transmitted through a banana-shaped path and then is reflected to the photoelectric receiver at the central position, and the photoelectric receiver converts an optical signal containing the blood sugar information of the human body into an electric signal. Because the current signal converted from the optical signal is very weak, in order to improve the resolution of the signal, the signal needs to be amplified and filtered, the signal passing through the signal conditioning circuit is sent to an AD port of the singlechip, the singlechip performs analog-to-digital conversion on the signal, and a complete blood sugar information acquisition is completed; and finally, uploading the blood sugar calculation result to a serial port screen through a single chip microcomputer for displaying, so that a complete blood sugar collection process is completed, and in addition, the equipment also has a wireless transmission function, can transmit the blood sugar information of the user to an intelligent mobile phone application for displaying, analyzing and storing, and can also obtain health guidance and service of professionals through an APP.
In conclusion, the invention develops the in-vivo non-invasive detection method and the in-vivo non-invasive detection device for the blood sugar of the human body by utilizing the difference of the absorption degrees of different components of the human tissue on near infrared light, does not cause harm to the human body, and simultaneously considers the interference of other tissue components, so that the non-invasive prediction model of the blood sugar is more stable and the prediction precision is higher. The blood sugar noninvasive detection method and the device thereof have the advantages that the finger tip area of the human body is selected as the monitoring area, the capillary vessels are rich, the near infrared light can better penetrate through the external structure to enter the dermal tissue, the obtained signal contains more useful information, and other interference components in human tissues and environmental influence factors are considered, for example, the influences of moisture, protein and human body temperature, the absorption conditions of 2 light sources in the wave bands of 1310nm and 1430nm of 1000-. Therefore, the invention provides a new solution for the noninvasive detection of blood sugar, and is beneficial to promoting the clinical application of the noninvasive detection of blood sugar.
Finally, the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all of them should be covered by the claims of the present invention.
Claims (10)
1. A non-invasive blood sugar detection device based on MIC-PCA-NARX correction algorithm comprises a signal conditioning circuit, a data storage module and a transmission module, and is characterized by further comprising a light source driving circuit, a constant temperature control module, a probe board and an MCU;
the probe plate integrates four light sources and a photoelectric receiver and is used for detecting a detected medium;
the light source driving circuit is connected with four light source positions of the probe plate, the constant temperature control module is connected with the probe plate, the output end of the probe plate is connected with the signal conditioning circuit, the output end of the signal conditioning circuit is connected with an A/D interface of the MCU, and the data storage module and the transmission module are connected with an I/O port of the MCU;
the light source driving circuit is used for providing working current for the four light sources;
the constant temperature control module is used for controlling the constant temperature of the finger contact area of the user during detection;
the MCU is used for receiving user input information, controlling the equipment to operate, transmitting and storing data and blood sugar values calculated by a blood sugar prediction model based on an MIC-PCA-NARX correction algorithm, wherein the MIC-PCA represents a maximum information coefficient principal component analysis method, and the NARX represents a time sequence;
the data storage module and the transmission module are respectively used for storing and sending the blood sugar detection result of the user.
2. The non-invasive blood glucose detecting apparatus according to claim 1, wherein the light source driving circuit comprises: a light source driving current circuit and a light source temperature control circuit.
3. The non-invasive blood glucose detection apparatus according to claim 1, wherein the signal conditioning circuit comprises: the current-to-voltage circuit, the filter circuit and the main amplifying circuit; the input end of the current-to-voltage circuit is connected with the output end of the photoelectric receiver of the probe plate, the input end of the filter circuit is connected with the output end of the current-to-voltage circuit, and the input end of the main amplification circuit is connected with the output end of the filter circuit.
4. The non-invasive blood glucose detecting device according to claim 1, wherein the thermostatic control module comprises a thermistor sensor, a triode switch circuit, a heating plate and a voltage dividing circuit, and is used for detecting the temperature of the contact area of the finger of the user; when a temperature rise instruction is input into the display module, the MCU acquires the voltage of the thermistor in the voltage division circuit, calculates the current temperature of the finger contact area through the voltage-temperature function of the thermistor, and outputs a high level to switch on the triode control circuit and the heating sheet to work if the temperature is lower than 35 ℃; otherwise, the MCU outputs a low level to cut off the triode control circuit, and the triode control circuit is disconnected to wait for temperature reduction.
5. The noninvasive blood glucose detecting device of claim 1, wherein four light sources integrated on the probe board surround the photoelectric receiver, and the central distance between any one light source and the photoelectric receiver is set to be 3.8-4.5 mm, and the central distance between every two light sources is 6-7 mm.
6. The non-invasive blood glucose detecting apparatus according to claim 1 or 5, wherein the four light sources comprise: 1 light source at 1310nm band of 1000-.
7. The non-invasive glucose detection apparatus according to claim 1, wherein the blood glucose prediction model based on MIC-PCA-NARX correction algorithm comprises: and reducing the dimension of the input variable by using an MIC-PCA method, and inputting a trained blood sugar prediction model to calculate the blood sugar by combining human tissue component diffuse reflection signals corresponding to four wavelengths of near infrared light detected in a constant temperature detection area.
8. The non-invasive glucose detection apparatus according to claim 7, wherein the blood glucose prediction model based on MIC-PCA-NARX correction algorithm further comprises: taking the blood glucose absorbance characterization value R as an input variable and the input variable subjected to MIC-PCA dimensionality reduction as the input of a subsequent NARX model;
the calculation formula of the blood glucose absorbance characterization value R is as follows:
R＝(λ1+λ2)/2-(λ3+λ4)/2
wherein λ is1，λ2Corresponding to the absorbance characterization value, lambda, of blood sugar of the main absorption component of 2 light sources with different wavelengths in the range of 1500-plus 1800nm for human body3，λ4The absorbance average value of the main absorption components of the light source in the ranges of 1350-1430nm and 1000-1310nm corresponding to human tissues.
9. The noninvasive blood glucose detection device of any one of claims 1-5, further comprising a display module connected to the I/O port of the MCU for providing a human-computer interface for inputting user information, displaying the blood glucose detection result and historical blood glucose information of the user, and controlling the operation of the device.
10. The noninvasive blood glucose detection device of any one of claims 1-5, further comprising a power module, wherein the power module is connected to the signal conditioning circuit, the MCU, the light source driving circuit, the display module, the thermostatic control module, the data storage module and the transmission module, and supplies power to each module.
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