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CN113316818A - 新生抗原的鉴定方法 - Google Patents

新生抗原的鉴定方法 Download PDF

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Publication number
CN113316818A
CN113316818A CN202080008090.2A CN202080008090A CN113316818A CN 113316818 A CN113316818 A CN 113316818A CN 202080008090 A CN202080008090 A CN 202080008090A CN 113316818 A CN113316818 A CN 113316818A
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tumor
sequencing
mutation
gene
cancer
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CN113316818B (zh
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姜宁
张文宏
田晔
仇超
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Jiang Ning
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Mark Zhun Biotechnology Co ltd
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
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Abstract

本发明涉及肿瘤免疫治疗的领域。具体而言，本发明提供了患者中肿瘤特异性新生抗原的鉴定方法和装置。通过本发明的方法或装置鉴定的新生抗原可用于开发针对所述肿瘤的疫苗或T细胞疗法。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN202080008090.2A 2019-03-15 2020-03-13 新生抗原的鉴定方法 Active CN113316818B (zh)

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CN201910198582.1A CN111696628A (zh) 2019-03-15 2019-03-15 新生抗原的鉴定方法
CN2019101985821 2019-03-15
PCT/CN2020/079131 WO2020187143A1 (zh) 2019-03-15 2020-03-13 新生抗原的鉴定方法

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CN113316818A true CN113316818A (zh) 2021-08-27
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115295084A (zh) * 2022-08-05 2022-11-04 南开大学 一种肿瘤新抗原免疫组库数据可视化分析方法和系统

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118326008A (zh) * 2024-04-18 2024-07-12 香港大学深圳医院 一种基于panel基因测序数据的肿瘤新抗原、筛选方法及应用
CN118351934B (zh) * 2024-04-26 2025-01-28 广州润生细胞医药科技有限责任公司 一种基于二代测序数据的肿瘤新抗原识别方法及系统
CN119446264B (zh) * 2025-01-09 2025-05-06 天津市肿瘤医院空港医院 一种恶性实体肿瘤的新抗原预测方法及系统
CN120319309A (zh) * 2025-03-28 2025-07-15 贵州生诺生物科技有限公司 一种抗原检测系统及其方法

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US20170199961A1 (en) * 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
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CN107704727A (zh) * 2017-11-03 2018-02-16 杭州风起智能科技有限公司 基于肿瘤新抗原特征值的新抗原活性预测和排序方法
CN108388773A (zh) * 2018-02-01 2018-08-10 杭州纽安津生物科技有限公司 一种肿瘤新生抗原的鉴定方法
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WO2018183544A1 (en) * 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Method for identification of retained intron tumor neoantigens from patient transcriptome

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CN108796055B (zh) * 2018-06-12 2022-04-08 深圳裕策生物科技有限公司 基于二代测序的肿瘤新生抗原检测方法、装置和存储介质
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US20170016075A1 (en) * 2015-07-14 2017-01-19 Personal Genome Diagnostics, Inc. Neoantigen analysis
WO2017024006A1 (en) * 2015-08-03 2017-02-09 The Johns Hopkins University Personalized, allogeneic cell therapy of cancer
US20170199961A1 (en) * 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
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WO2018183544A1 (en) * 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Method for identification of retained intron tumor neoantigens from patient transcriptome
CN107704727A (zh) * 2017-11-03 2018-02-16 杭州风起智能科技有限公司 基于肿瘤新抗原特征值的新抗原活性预测和排序方法
CN108388773A (zh) * 2018-02-01 2018-08-10 杭州纽安津生物科技有限公司 一种肿瘤新生抗原的鉴定方法
CN108491689A (zh) * 2018-02-01 2018-09-04 杭州纽安津生物科技有限公司 基于转录组的肿瘤新抗原鉴定方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115295084A (zh) * 2022-08-05 2022-11-04 南开大学 一种肿瘤新抗原免疫组库数据可视化分析方法和系统

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WO2020187143A1 (zh) 2020-09-24
CN111696628A (zh) 2020-09-22

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