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CN113166251A - 抗人tim-3单克隆抗体及其应用 - Google Patents

抗人tim-3单克隆抗体及其应用 Download PDF

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Publication number
CN113166251A
CN113166251A CN201980079364.4A CN201980079364A CN113166251A CN 113166251 A CN113166251 A CN 113166251A CN 201980079364 A CN201980079364 A CN 201980079364A CN 113166251 A CN113166251 A CN 113166251A
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China
Prior art keywords
antibody
variable region
chain variable
tim
light chain
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CN201980079364.4A
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CN113166251B (zh
Inventor
宋宁宁
段清
刘礼乐
杨达志
徐丽娜
刘虎
卫培培
王倩
王远东
邵晓慧
胡少平
张瑜
吴建
王美玲
王冬旭
戴朝晖
王梦莹
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Pharmaexplorer Ltd
Shanghai Pharmaexplorer Co Ltd
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Pharmaexplorer Ltd
Shanghai Pharmaexplorer Co Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07—ORGANIC CHEMISTRY
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicinal Preparation (AREA)

Abstract

提供了一种高特异性靶向TIM‑3的高亲和力全人单克隆抗体及其制备方法，所述单抗具有显著的抗肿瘤活性，可用于制备相关的诊断试剂或者预防或治疗与TIM‑3功能异常相关的疾病的药物组合物。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201980079364.4A 2018-11-30 2019-12-02 抗人tim-3单克隆抗体及其应用 Active CN113166251B (zh)

Applications Claiming Priority (3)

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CN201811459248.9A CN111253485A (zh) 2018-11-30 2018-11-30 抗人tim-3单克隆抗体及其应用
CN2018114592489 2018-11-30
PCT/CN2019/122471 WO2020108660A1 (zh) 2018-11-30 2019-12-02 抗人tim-3单克隆抗体及其应用

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CN113166251A true CN113166251A (zh) 2021-07-23
CN113166251B CN113166251B (zh) 2022-08-16

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US (1) US20220033501A1 (zh)
EP (1) EP3901171A4 (zh)
JP (1) JP2022508309A (zh)
CN (2) CN111253485A (zh)
WO (1) WO2020108660A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112961239B (zh) * 2021-02-24 2021-09-10 北京昭衍生物技术有限公司 Tim抑制剂及其应用
CN114751985A (zh) * 2022-06-07 2022-07-15 日照市疾病预防控制中心 Tim-3抗体、制备方法及其应用
CN115561458B (zh) * 2022-07-08 2023-12-05 华中科技大学同济医学院附属协和医院 用于诊断胆道闭锁的胶体金快速检测卡及其制备方法
WO2025090985A1 (en) * 2023-10-27 2025-05-01 Duke University Compositions comprising chimeric antigen receptors targeting citrullinated vimentin and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
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CN102492038A (zh) * 2011-12-09 2012-06-13 中国人民解放军军事医学科学院基础医学研究所 抗人Tim-3的中和性单克隆抗体L3D及其用途
CN103073644A (zh) * 2012-12-31 2013-05-01 中国科学技术大学 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用
WO2017178493A1 (en) * 2016-04-12 2017-10-19 Symphogen A/S Anti-tim-3 antibodies and compositions

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GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
NZ556029A (en) * 2004-12-21 2010-04-30 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
GB0624500D0 (en) * 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
ES2613730T3 (es) 2008-12-18 2017-05-25 Erasmus University Medical Center Rotterdam Animales transgénicos no humanos que expresan anticuerpos humanizados y su uso
AU2011262758B8 (en) * 2010-06-11 2014-09-04 Kyowa Kirin Co., Ltd. Anti-tim-3 antibody
JOP20200096A1 (ar) * 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
IL248511B (en) * 2014-05-13 2022-07-01 Bavarian Nordic As Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3
CA2874083C (en) * 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
US20160200815A1 (en) * 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
CN104592388B (zh) * 2015-03-02 2017-05-31 中国人民解放军总医院 一种抗人Tim‑3的单克隆抗体的抗原结合部分
BR112019000431A2 (pt) * 2016-07-14 2019-07-09 Bristol-Myers Squibb Company anticorpos contra tim3 e usos dos mesmos
US11939380B2 (en) * 2017-04-05 2024-03-26 Les Laboratoires Servier Combination therapies targeting PD-1, TIM-3, and LAG-3

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102492038A (zh) * 2011-12-09 2012-06-13 中国人民解放军军事医学科学院基础医学研究所 抗人Tim-3的中和性单克隆抗体L3D及其用途
CN103073644A (zh) * 2012-12-31 2013-05-01 中国科学技术大学 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用
WO2017178493A1 (en) * 2016-04-12 2017-10-19 Symphogen A/S Anti-tim-3 antibodies and compositions

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Publication number Publication date
US20220033501A1 (en) 2022-02-03
EP3901171A4 (en) 2022-08-03
CN111253485A (zh) 2020-06-09
EP3901171A1 (en) 2021-10-27
JP2022508309A (ja) 2022-01-19
CN113166251B (zh) 2022-08-16
WO2020108660A1 (zh) 2020-06-04

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