CN112741840A - B-vitamin dietary fiber effervescent tablet and preparation method thereof - Google Patents
B-vitamin dietary fiber effervescent tablet and preparation method thereof Download PDFInfo
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- CN112741840A CN112741840A CN202011582962.4A CN202011582962A CN112741840A CN 112741840 A CN112741840 A CN 112741840A CN 202011582962 A CN202011582962 A CN 202011582962A CN 112741840 A CN112741840 A CN 112741840A
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- Prior art keywords
- vitamin
- dietary fiber
- effervescent tablet
- acid
- vitamins
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- 235000013325 dietary fiber Nutrition 0.000 title claims abstract description 74
- 235000019156 vitamin B Nutrition 0.000 title claims abstract description 71
- 239000011720 vitamin B Substances 0.000 title claims abstract description 71
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 229940088594 vitamin Drugs 0.000 claims abstract description 26
- 229930003231 vitamin Natural products 0.000 claims abstract description 26
- 235000013343 vitamin Nutrition 0.000 claims abstract description 26
- 239000011782 vitamin Substances 0.000 claims abstract description 26
- 239000002253 acid Substances 0.000 claims abstract description 17
- 239000003513 alkali Substances 0.000 claims abstract description 17
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 14
- 239000003765 sweetening agent Substances 0.000 claims abstract description 14
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 13
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- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 36
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 36
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 36
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract
The invention belongs to the technical field of health care products, and particularly relates to a B-group vitamin dietary fiber effervescent tablet and a preparation method thereof. The B-group vitamin dietary fiber effervescent tablet comprises the raw materials of B-group vitamins, dietary fibers, an acid source, an alkali source, sugar alcohol, a sweetening agent and essence. The effervescent tablet combines the dosage form of the effervescent tablet with dietary fiber for the first time, supplements B vitamins, increases the intake of the body to the dietary fiber, is eaten in a more favorite eating mode of people, namely the form of the effervescent tablet, has strong effervescent feeling, meets the requirement of the public on beverage, promotes intestinal digestion and absorption, improves the endogenous bioavailability of each effective component, and improves the autoimmunity of the human body.
Description
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a B-group vitamin dietary fiber effervescent tablet and a preparation method thereof.
Background
Vitamins are a class of low molecular weight compounds that cannot be synthesized in the body, but are one of the seven major nutrients required by the human body. The vitamin required by human body is very small, but the vitamin is as important as protein, carbohydrate and other nutrients, has the function of maintaining normal physiological function of human body, and plays an important regulating role in the process of substance metabolism. The vitamins are divided into water-soluble vitamins and fat-soluble vitamins, wherein the B vitamins belong to the water-soluble vitamins.
The B vitamins mainly come from yeast, grains, animal livers, animal kidneys and the like, are essential nutrients for human tissues, participate in the metabolism of sugar, protein and fat in the body and are the key of releasing energy of food. The B vitamins include vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, and biotin. The B vitamins have a synergistic effect, and all the vitamin B plays a role at the same time, which is called the fusion effect of the B vitamins. The effects of various vitamins B are complementary to each other because the activity of cells is increased and thus the demand of the vitamins B is increased when the vitamins B are taken alone. For example: vitamin B6 promotes the absorption of vitamin B12, vitamin B12 and folic acid can act synergistically, and biotin can participate in the metabolism of vitamin B12, folic acid and pantothenic acid.
Dietary fiber is called "seventh macronutrient" of human, and is polysaccharide that is not digested by digestive enzymes in gastrointestinal tract in plant food such as grains and beans, and is not absorbed and utilized. The dietary fiber comprises cellulose, hemicellulose, lignin, gum, pectin and the like, and the recommended intake of the dietary fiber in a human body is obviously higher than the recommended intake of trace elements such as vitamins, minerals and the like. The dietary fiber has certain physiological effects in controlling weight, regulating blood sugar, reducing blood lipid, increasing intestinal tract function, improving intestinal flora and enhancing immunity.
The effervescent tablet is a common preparation formulation on the market, and is a formulation loved by the public; the effervescent disintegrant is prepared by the reaction of acid and alkali, and is put into water to generate an effervescent reaction immediately; has the characteristics of convenient taking, good taste, high bioavailability, and convenient carrying, transportation and storage; is especially suitable for children, the elderly and people with difficulty in swallowing the preparation.
At present, the need of providing an effervescent tablet which can supplement the vitamin B group and dietary fiber required by human body is needed.
Disclosure of Invention
The invention aims to provide a B-group vitamin dietary fiber effervescent tablet which is used for supplementing B-group vitamins and dietary fibers required by a human body while meeting the requirements of the public on taste buds, improving intestinal microcirculation, protecting intestinal health, improving the endogenous bioavailability of B-group vitamins of the body and improving the immunity of the human body; the invention also provides a preparation method of the B-group vitamin dietary fiber effervescent tablet, which is scientific, reasonable, simple and feasible.
The B-group vitamin dietary fiber effervescent tablet provided by the invention comprises the raw materials of B-group vitamins, dietary fibers, an acid source, an alkali source, sugar alcohol, a sweetening agent and essence.
The vitamin B group is a mixture of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, pantothenic acid and biotin.
The mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 9.5-11: 8.7-10.5: 8.7-10.5: 0.015-0.016: 0.85-1: 42-49: 14.5-17.5: 0.09-0.1.
The dietary fiber is one or more of fructo-oligosaccharide, galacto-oligosaccharide, polydextrose, xylo-oligosaccharide, isomalto-oligosaccharide or inulin.
The mass ratio of the dietary fiber to the B vitamins is 2-5: 1.
the acid source is one or more of anhydrous citric acid, malic acid, tartaric acid or fumaric acid.
The alkali source is one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate or potassium carbonate.
The molar ratio of the acid source to the alkali source is 0.6: 1.
the weight ratio of the acid source and the alkali source in the B-family vitamin dietary fiber effervescent tablet is not less than 50%.
The sugar alcohol is one or more of lactitol, sorbitol, isomaltitol, mannitol, erythritol or D-mannitol.
The sweetener is one or more of sucralose, aspartame, acesulfame potassium, sodium cyclamate or stevioside.
The B-vitamin dietary fiber effervescent tablet provided by the invention is prepared from the following raw materials in parts by weight:
the B-vitamin dietary fiber effervescent tablet disclosed by the invention is preferably prepared from the following raw materials in parts by weight:
the B-vitamin dietary fiber effervescent tablet disclosed by the invention is more preferably prepared from the following raw materials in parts by weight:
the B-vitamin dietary fiber effervescent tablet disclosed by the invention is more preferably prepared from the following raw materials in parts by weight:
the B-vitamin dietary fiber effervescent tablet disclosed by the invention further comprises lactose in an amount of 10-30 parts.
When the raw materials are B vitamins, dietary fibers, an acid source, an alkali source, sugar alcohol, a sweetening agent and essence, the preparation method of the B vitamins and dietary fibers effervescent tablet comprises the steps of mixing the B vitamins, the dietary fibers, the acid source, the alkali source, the sugar alcohol, the sweetening agent and the essence, and tabletting.
When the raw materials are B vitamins, dietary fibers, an acid source, an alkali source, lactose, sugar alcohol, a sweetening agent and essence, the preparation method of the B vitamins and dietary fibers effervescent tablet comprises the steps of granulating the dietary fibers and the lactose, adding the B vitamins, the acid source, the alkali source, the sugar alcohol, the sweetening agent and the essence, mixing, and tabletting.
The invention has the following beneficial effects:
the effervescent tablet combines the dosage form of the effervescent tablet with dietary fiber for the first time, supplements B vitamins, increases the intake of the body to the dietary fiber, is eaten in a more favorite eating mode of people, namely the form of the effervescent tablet, has strong effervescent feeling, meets the requirement of the public on beverage, promotes intestinal digestion and absorption, improves the endogenous bioavailability of each effective component, and improves the autoimmunity of the human body.
The invention adds the dietary fiber into the B vitamins, and under the synergistic effect of the dietary fiber, the invention is matched with a proper amount of acid-base, sweetener and essence to promote the digestion and absorption of the B vitamins, and has good taste and strong experience.
Detailed Description
The present invention is further described below with reference to examples.
The raw materials or auxiliary materials used in the examples are all available on the market.
Example 1
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 1.
Table 1B vitamins dietary fiber effervescent tablet raw material composition of example 1
| B vitamins | 1.25 |
| Citric acid (Anhydrous) | 28 |
| Sodium bicarbonate | 22 |
| Sorbitol | 41.09 |
| Cyclohexyl amino sodium sulfonate (sodium cyclamate) | 0.4 |
| Sucralose | 0.06 |
| Asparagus phenylalanine methyl ester (Aspartame) | 0.2 |
| Edible essence | 1 |
| Polydextrose | 6 |
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 9.5: 8.7: 8.7: 0.015: 0.85: 42: 14.5: 0.09.
the preparation method comprises the following steps:
(1) weighing and preparing materials
Weighing all the raw materials according to the formula amount, and selecting whether to crush, premix or screen according to the properties of the materials.
(2) Mixing
Placing the B vitamins, the dietary fiber, the acid source, the alkali source, the sugar alcohol, the sweetener and the essence into a mixer, and mixing until the color and the texture of the mixed material are uniform.
(3) Tabletting
Tabletting with a tabletting machine, and periodically checking for tablet weight differences.
(4) Inner package
And (4) filling the qualified tablets into a packaging material, sealing, and then transferring to the next procedure.
(5) External packing
Labeling and boxing.
(6) Inspecting and warehousing
After the quality of the product to be detected is qualified through sampling inspection, the warehousing procedure is handled according to the inspection report sheet, the qualification certificate and the warehousing sheet.
Example 2
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 2.
Table 2 vitamin B dietary fiber effervescent tablet raw material composition of example 2
| B vitamins | 1.25 |
| Citric acid (Anhydrous) | 30 |
| Sodium bicarbonate | 20 |
| Sorbitol | 41.09 |
| Cyclohexyl amino sodium sulfonate (sodium cyclamate) | 0.4 |
| Sucralose | 0.09 |
| Asparagus phenylalanine methyl ester (Aspartame) | 0.27 |
| Edible essence | 1 |
| Polydextrose | 6 |
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 11: 10.5: 10.5: 0.016: 1: 49: 17.5: 0.1.
the preparation method is the same as example 1.
Example 3
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 3.
Table 3B vitamins dietary fiber effervescent tablet raw material composition of example 3
| B vitamins | 1.25 |
| Citric acid (Anhydrous) | 30 |
| Sodium bicarbonate | 20 |
| Sorbitol | 21.09 |
| Lactose | 20 |
| Cyclohexyl amino sodium sulfonate (sodium cyclamate) | 0.4 |
| Sucralose | 0.09 |
| Asparagus phenylalanine methyl ester (Aspartame) | 0.27 |
| Edible essence | 1 |
| Polydextrose | 6 |
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 10: 9.5: 9.3: 0.015: 0.9: 45: 16: 0.1.
the preparation method comprises the following steps:
(1) weighing and preparing materials
Weighing all the raw materials according to the formula amount, and selecting whether to crush, premix or screen according to the properties of the materials.
(2) Granulating
Granulating dietary fiber and lactose, oven drying until water content is less than or equal to 0.5%, and grading to obtain dry granule.
(3) Mixing
Placing the B vitamins, the acid source, the alkali source, the sugar alcohol, the sweetener, the essence and the dry particles into a mixer, and mixing until the color and the texture of the mixed material are uniform.
(4) Tabletting
Tabletting with a tabletting machine, and periodically checking for tablet weight differences.
(5) Inner package
And (4) filling the qualified tablets into a packaging material, sealing, and then transferring to the next procedure.
(6) External packing
Labeling and boxing.
(7) Inspecting and warehousing
After the quality of the product to be detected is qualified through sampling inspection, the warehousing procedure is handled according to the inspection report sheet, the qualification certificate and the warehousing sheet.
Example 4
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 4.
Table 4 vitamin B dietary fiber effervescent tablet raw material composition of example 4
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 9.5: 10.5: 8.7: 0.016: 0.85: 49: 14.5: 0.1.
the preparation method is the same as example 3.
Example 5
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 5.
Table 5 vitamin B dietary fiber effervescent tablet raw material composition of example 5
| B vitamins | 1.25 |
| Citric acid (Anhydrous) | 30 |
| Sodium bicarbonate | 20 |
| Sorbitol | 44.09 |
| Cyclohexyl amino sodium sulfonate (sodium cyclamate) | 0.4 |
| Sucralose | 0.09 |
| Asparagus phenylalanine methyl ester (Aspartame) | 0.27 |
| Edible essence | 1 |
| Polydextrose | 3 |
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 11: 10: 9.5: 0.015: 1: 48: 17.5: 0.1.
the preparation method is the same as example 1.
Example 6
The composition of the B vitamin dietary fiber effervescent tablet raw materials in parts by weight is shown in Table 6.
Table 6B vitamins dietary fiber effervescent tablet raw material composition of example 6
The B vitamins are vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, a mixture of pantothenic acid and biotin, and the mass ratio of the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the folic acid, the nicotinamide, the pantothenic acid and the biotin is 9.5: 10.2: 9: 0.015: 0.85: 43: 16.5: 0.09.
the preparation method is the same as example 3.
The B-vitamin dietary fiber effervescent tablets prepared in the examples 1 to 6 are detected, and the detection results are as follows:
1. the performance indexes of the B-vitamin dietary fiber effervescent tablets prepared in the examples 1 to 6, such as angle of repose, hardness, friability and the like, are detected, and the detection results are shown in Table 7.
TABLE 7 Performance indices of B-vitamin dietary fiber effervescent tablets prepared in examples 1-6
2. The B-vitamin dietary fiber effervescent tablets prepared in example 2 and example 6 were taken, and 20 sensory evaluation persons were asked to evaluate the effervescent tablets prepared in example 2 and example 6 according to 4 sensory indexes of appearance, smell, taste and novelty, wherein each index was full of 5 points, the total full of 20 points, and the evaluation results were averaged. Sensory index scoring results are shown in tables 8 and 9.
Table 8 sensory evaluation of B vitamin dietary fiber effervescent tablets of example 2
Table 9 sensory evaluation of B vitamin dietary fiber effervescent tablets of example 6
As can be seen from tables 8 and 9, the products of examples 2 and 6 have good sensory properties, good aroma, good taste when dissolved in the oral cavity, novel product and high acceptability.
3. The B-group vitamin dietary fiber effervescent tablets of examples 1-6 were tested for sticking and at the same time, evaluated as described in taste experience. The results are shown in Table 10.
Table 10B vitamin dietary fiber effervescent tablets of examples 1-6 have a sliming performance and mouthfeel experience
| Test items | Sticking phenomenon | Taste experience |
| Example 1 | Is not easy to be adhered and punched | The taste is sour and sweet |
| Example 2 | Is not easy to be adhered and punched | Has sweet and sour taste |
| Example 3 | Is not easy to be adhered and punched | Has sweet and sour taste |
| Example 4 | Is not easy to be adhered and punched | The taste is sour and sweet |
| Example 5 | Is not easy to be adhered and punched | Has sweet and sour taste |
| Example 6 | Is not easy to be adhered and punched | Has sweet and sour taste |
Claims (10)
1. A B-group vitamin dietary fiber effervescent tablet is characterized in that raw materials comprise B-group vitamins, dietary fibers, an acid source, an alkali source, sugar alcohol, a sweetening agent and essence.
2. The B vitamin dietary fiber effervescent tablet according to claim 1, wherein the B vitamin is a mixture of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, pantothenic acid and biotin, the mass ratio of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinamide, pantothenic acid and biotin is 9.5-11: 8.7-10.5: 8.7-10.5: 0.015-0.016: 0.85-1: 42-49: 14.5-17.5: 0.09-0.1.
3. The B-vitamin dietary fiber effervescent tablet according to claim 1, wherein the dietary fiber is one or more of fructo-oligosaccharide, galacto-oligosaccharide, polydextrose, xylo-oligosaccharide, isomalto-oligosaccharide or inulin, and the mass ratio of the dietary fiber to the B-vitamin is 2-5: 1.
4. the B vitamin dietary fiber effervescent tablet of claim 1, wherein the acid source is one or more of anhydrous citric acid, malic acid, tartaric acid or fumaric acid, the alkali source is one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate or potassium carbonate, and the molar ratio of the acid source to the alkali source is 0.6: 1.
5. the B vitamin dietary fiber effervescent tablet of claim 1, wherein the sugar alcohol is one or more of lactitol, sorbitol, isomalt, mannitol, erythritol or D-mannitol.
6. The B vitamin dietary fiber effervescent tablet of claim 1, wherein the sweetener is one or more of sucralose, aspartame, acesulfame potassium, sodium cyclamate or stevioside.
7. The B vitamin dietary fiber effervescent tablet according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
8. the B vitamin dietary fiber effervescent tablet according to claim 1, characterized in that the raw materials further comprise lactose, and the addition amount of the lactose is 10-30 parts.
9. A method for preparing the B vitamin dietary fiber effervescent tablet according to any one of claims 1 to 7, which is characterized in that the B vitamin, the dietary fiber, the acid source, the alkali source, the sugar alcohol, the sweetener and the essence are mixed and tableted to obtain the B vitamin dietary fiber effervescent tablet.
10. A preparation method of the B vitamin dietary fiber effervescent tablet according to claim 8, wherein the B vitamin, the acid source, the alkali source, the sugar alcohol, the sweetener and the essence are added after the dietary fiber and the lactose are granulated, and the B vitamin effervescent tablet is obtained by tabletting.
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| CN114432259A (en) * | 2022-01-12 | 2022-05-06 | 澳美制药(苏州)有限公司 | Electrolyte effervescent tablet and preparation method thereof |
| CN116439378A (en) * | 2023-04-07 | 2023-07-18 | 柏维力生物技术(安徽)股份有限公司 | Rapidly disintegrating effervescent tablet composition and preparation method thereof |
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| WO2020078036A1 (en) * | 2018-10-17 | 2020-04-23 | 汤臣倍健股份有限公司 | Micro-effervescent buccal tablet and preparation method thereof |
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| CN113498862A (en) * | 2021-08-27 | 2021-10-15 | 上海英库商务咨询有限公司 | Diet formula capable of preventing beriberi, herpes and corner inflammation and losing weight |
| CN114432259A (en) * | 2022-01-12 | 2022-05-06 | 澳美制药(苏州)有限公司 | Electrolyte effervescent tablet and preparation method thereof |
| CN114432259B (en) * | 2022-01-12 | 2023-03-03 | 澳美制药(苏州)有限公司 | Electrolyte effervescent tablet and preparation method thereof |
| CN116439378A (en) * | 2023-04-07 | 2023-07-18 | 柏维力生物技术(安徽)股份有限公司 | Rapidly disintegrating effervescent tablet composition and preparation method thereof |
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