CN112439006A - Traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and preparation method thereof Download PDFInfo
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- CN112439006A CN112439006A CN202011315740.6A CN202011315740A CN112439006A CN 112439006 A CN112439006 A CN 112439006A CN 202011315740 A CN202011315740 A CN 202011315740A CN 112439006 A CN112439006 A CN 112439006A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 11-13 parts of cantharis whole worm, 45-55 parts of salicylic acid and 3-5 parts of menthol; the Chinese medicinal composition is in the form of tincture, ointment, plaster, gel or patch; the tincture also contains 75% ethanol, and the Chinese medicinal composition is soaked in 75% ethanol. The invention has the beneficial effects that: the formula is novel, the preparation is convenient and easy to realize, the treatment effect is obvious, the ointment has good effects of removing thick scabs, relieving itching and diminishing inflammation, an affected part feels cool and comfortable after applying the ointment, the pain of a patient suffering from intractable neurodermatitis is relieved, and the defect of a hormone external liniment is overcome.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and a preparation method thereof.
Background
Neurodermatitis, also called as chronic simple lichen, is a chronic functional disorder of skin characterized by paroxysmal pruritus and lichen, and is very painful in severe cases with flaky and thick papules and moss-like changes. The symptoms are mild and severe, and the disease is easy to relapse after being cured.
At present, the intractable neurodermatitis is treated by adopting antihistamine medicine vein and local sealing treatment generally, the treatment mainly depends on 4 types of medicines, namely, corticoids, immunosuppressants, antihistamines and moisturizing emollients, one or more medicines are generally selected to be matched or used alternatively, glucocorticoid medicines are mostly adopted for external use, and the western medicine for treating eczema has quick response but has the defects of incomplete treatment, easy relapse and large side effect.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and a preparation method thereof.
The technical scheme adopted by the invention is as follows: a traditional Chinese medicine composition for treating intractable neurodermatitis is characterized by comprising the following raw material medicines: radix Euphorbiae Fischerianae, Mylabris Scorpio, radix Sophorae Flavescentis, radix et rhizoma Rhei, Borneolum Syntheticum, salicylic acid, and Mentholum.
The Chinese stellera root has the effects of dissipating stagnation and killing insects, is externally used for skin itch, psoriasis and the like, contains gallic acid and derivatives thereof in chemical components, and has the current pharmacodynamic research that the gallic acid has the effects of resisting inflammation, mutation and tumor, can inhibit the metastasis of mast cell tumor and has good antibacterial and antiviral effects;
the cantharis whole worm, cantharis is virulent, pungent and hot, have blood stasis breaking, stasis removing, stagnation dissipating, decay eliminating, toxic material counteracting, sore-removing efficacy, it is suitable for stubborn tinea, wart, malignant sore, dead muscle, etc. to use externally, its chemical composition is mainly cantharidin and derivant, cantharidin has stronger irritation to the mucosa of skin, can cause the local to become red and bubble, but its penetrating power to tissue is smaller, does not involve the deep layer of skin, the blister formed is fully healed very fast without leaving the scar, because cantharidin can stimulate macrophage to produce abundantly while foaming, therefore utilize this characteristic to treat many diseases.
Kuh-seng, bitter in taste and cold in nature, is externally used for killing parasites and relieving itching, and is used for treating eczema, mange, leprosy and other symptoms; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
rhubarb, radix et rhizoma Rhei, bitter in flavor and cold in nature, has the effects of removing food retention, clearing damp-heat, purging fire, cooling blood, removing blood stasis and detoxifying, and can be used for treating pyocutaneous disease and pyogenic infections by external application.
Borneol, being pungent, bitter and cool in nature and flavor, is externally used for sore and swelling disease without healing after ulceration, and has the functions of clearing away heat and toxic material, preventing corrosion and promoting granulation.
Salicylic acid has the functions of sterilization, inflammation diminishing and cutin removing, and is a common component of chemical external drugs.
Menthol, which is used as an irritant in medicine, acts on the skin or mucous membrane to cool and relieve itching.
The prescription fully considers the pharmacodynamics characteristics of each component, adopts the Chinese stellera root with the functions of dissipating stagnation and resisting bacteria, the lightyellow sophora root with the bitter taste and cold property and the functions of killing parasites and relieving itching and the rhubarb with the functions of purging intense heat, cooling blood, removing stasis and detoxifying, utilizes the cytotoxicity and the foaming characteristics of cantharidin, combines the cutin removing and inflammation diminishing characteristics of salicylic acid, can fully remove the thick scab of intractable neurodermatitis, better controls the concentration of the cantharidin, has smaller stimulation degree, is assisted with the menthol with the functions of cooling and relieving itching, and makes the affected part feel cool and comfortable after being applied.
The used medicine has good effects of inhibiting and removing skin lichenification, and has the effects of relieving itching, diminishing inflammation, removing blood stasis, detoxifying and the like, and the medicines are used together to directly reach the pathological change part, thereby fully playing the curative effect.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 18-22 parts of borneol, 11-13 parts of blister beetle, 45-55 parts of salicylic acid and 3-5 parts of menthol, and clinical comparison data prove that the proportioning is reasonable.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 40 parts of radix sophorae flavescentis, 40 parts of rheum officinale, 25 parts of borneol, 12 parts of cantharis whole worm, 50 parts of salicylic acid and 4 parts of menthol.
Further comprises one or more of caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, herba Erigerontis, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, and Bulbus Lilii.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 11-13 parts of cantharis whole worm, 45-55 parts of salicylic acid, 3-5 parts of menthol, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily. Clinical comparative data prove that the proportioning setting is reasonable.
Furthermore, the dosage form of the traditional Chinese medicine composition is tincture, ointment, plaster, gel or patch. The Chinese medicinal composition can be prepared into various dosage forms, and is suitable for different conditions.
The application of a traditional Chinese medicine composition for treating intractable neurodermatitis in preparing a medicine for treating intractable neurodermatitis, dermatitis or keratoderma is provided.
The tincture of the traditional Chinese medicine composition for treating intractable neurodermatitis is characterized by further comprising 75% ethanol. Tincture is a clear liquid preparation prepared by extracting or dissolving raw medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract.
A method for preparing a Chinese medicinal composition for treating intractable neurodermatitis is characterized by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris Scorpio, sieving with 100 mesh sieve to obtain fine powder, adding Mentholum, Borneolum Syntheticum and salicylic acid, and mixing well to obtain the final product. The preparation is simple and easy to realize.
A method for preparing a Chinese medicinal tincture for treating intractable neurodermatitis comprises pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris, sieving with 100 mesh sieve, pulverizing into fine powder, adding Mentholum, Borneolum Syntheticum and salicylic acid, soaking in 1300ml of 75% ethanol 1100 for 10 days, stirring for several times, filtering, and packaging in glass bottles.
The invention has the beneficial effects that: the external liniment has the advantages of novel formula, convenient and easy preparation, obvious treatment effect, good effects of relieving itching, diminishing inflammation and decrustation, thorough treatment, difficult recurrence, small side effect, good effect of all 81 cases of clinical observation, capability of relieving the pain of patients with intractable neurodermatitis, remarkable clinical effect and capability of making up the defects of hormone external liniments.
Detailed Description
The following is a description of specific embodiments of the present invention.
The invention relates to a traditional Chinese medicine composition for treating intractable neurodermatitis, which comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, Mentholum, Borneolum Syntheticum, Mylabris Scorpio, and salicylic acid.
The Chinese stellera root has the effects of dissipating stagnation and killing insects, is externally used for skin itch, psoriasis and the like, contains gallic acid and derivatives thereof in chemical components, and has the current pharmacodynamic research that the gallic acid has the effects of resisting inflammation, mutation and tumor, can inhibit the metastasis of mast cell tumor and has good antibacterial and antiviral effects;
the cantharis whole worm, cantharis is virulent, pungent and hot, have blood stasis breaking, stasis removing, stagnation dissipating, decay eliminating, toxic material counteracting, sore-removing efficacy, it is suitable for stubborn tinea, wart, malignant sore, dead muscle, etc. to use externally, its chemical composition is mainly cantharidin and derivant, cantharidin has stronger irritation to the mucosa of skin, can cause the local to become red and bubble, but its penetrating power to tissue is smaller, does not involve the deep layer of skin, the blister formed is fully healed very fast without leaving the scar, because cantharidin can stimulate macrophage to produce abundantly while foaming, therefore utilize this characteristic to treat many diseases.
Kuh-seng, bitter in taste and cold in nature, is externally used for killing parasites and relieving itching, and is used for treating eczema, mange, leprosy and other symptoms; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
rhubarb, radix et rhizoma Rhei, bitter in flavor and cold in nature, has the effects of removing food retention, clearing damp-heat, purging fire, cooling blood, removing blood stasis and detoxifying, and can be used for treating pyocutaneous disease and pyogenic infections by external application.
Borneol, being pungent, bitter and cool in nature and flavor, is externally used for sore and swelling disease without healing after ulceration, and has the functions of clearing away heat and toxic material, preventing corrosion and promoting granulation.
Salicylic acid has the functions of sterilization, inflammation diminishing and cutin removing, and is a common component of chemical external drugs.
Menthol, which is used as an irritant in medicine, acts on the skin or mucous membrane to cool and relieve itching.
The prescription fully considers the pharmacodynamics characteristics of each component, adopts the Chinese stellera root with the functions of dissipating stagnation and resisting bacteria, the lightyellow sophora root with the bitter taste and cold property and the functions of killing parasites and relieving itching and the rhubarb with the functions of purging intense heat, cooling blood, removing stasis and detoxifying, utilizes the cytotoxicity and the foaming characteristics of cantharidin, combines the cutin removing and inflammation diminishing characteristics of salicylic acid, can fully remove the thick scab of intractable neurodermatitis, better controls the concentration of the cantharidin, has smaller stimulation degree, is assisted with the menthol with the functions of cooling and relieving itching, and makes the affected part feel cool and comfortable after being applied.
The used medicine has good effects of inhibiting and removing skin lichenification, and has the effects of relieving itching, diminishing inflammation, removing blood stasis, detoxifying and the like, and the medicines are used together to directly reach the pathological change part, thereby fully playing the curative effect.
The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 18-22 parts of borneol, 11-13 parts of blister beetle, 45-55 parts of salicylic acid and 3-5 parts of menthol, and clinical comparison data prove that the proportioning is reasonable.
The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 40 parts of radix sophorae flavescentis, 40 parts of rheum officinale, 25 parts of borneol, 12 parts of cantharis whole worm, 50 parts of salicylic acid and 4 parts of menthol.
Also comprises one or more of caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, flos Hibisci, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, and Bulbus Lilii.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 11-13 parts of cantharis whole worm, 45-55 parts of salicylic acid, 3-5 parts of menthol, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily. Clinical comparative data prove that the proportioning setting is reasonable.
The dosage form of the traditional Chinese medicine composition is tincture, ointment, plaster, gel or patch. The Chinese medicinal composition can be prepared into various dosage forms, and is suitable for different conditions.
The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract.
Ethanol 75% is used for disinfection. Because too high a concentration of alcohol forms a protective film on the surface of bacteria to prevent it from entering the body of bacteria, it is difficult to kill bacteria thoroughly. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body can not be coagulated, and the bacteria can not be completely killed, and 75% ethanol is suitable for disinfection.
The application of a traditional Chinese medicine composition for treating intractable neurodermatitis in preparing a medicine for treating intractable neurodermatitis, dermatitis or keratoderma is provided. The traditional Chinese medicine composition for treating intractable neurodermatitis can be used for treating eczema and also can be used for treating dermatitis or keratoderma.
The tincture of the traditional Chinese medicine composition for treating intractable neurodermatitis also comprises 1200ml of 75% ethanol. The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract. The concentration of the tincture is otherwise specified, and each 100ml of the tincture contains 10g of drug (medicinal materials); the other tincture is equivalent to 20g of the original medicine per 100 ml.
A Chinese medicinal composition for treating intractable neurodermatitis is prepared by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris Scorpio, adding Mentholum, Borneolum Syntheticum and salicylic acid, and mixing. The preparation is simple and easy to realize.
A method for preparing a Chinese medicinal tincture for the treatment of intractable neurodermatitis comprises pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris Scorpio, adding Mentholum, Borneolum Syntheticum and salicylic acid, soaking in 1200ml 75% ethanol for 10 days, stirring for several times, filtering, and packaging in glass bottles.
Compared with the prior art, the external liniment has the advantages of novel formula, convenient and easy preparation, obvious treatment effect, good effects of relieving itching, diminishing inflammation and decrustation, thorough treatment, small possibility of relapse, small side effect, good effect in clinical observation of 81 cases, capability of relieving the pain of patients with intractable neurodermatitis, remarkable clinical effect and capability of making up the defects of hormone external liniments.
Example 1
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, Borneolum Syntheticum, Mylabris Scorpio, salicylic acid, and Mentholum.
The Chinese stellera root has the effects of dissipating stagnation and killing insects, is externally used for skin itch, psoriasis and the like, contains gallic acid and derivatives thereof in chemical components, and has the current pharmacodynamic research that the gallic acid has the effects of resisting inflammation, mutation and tumor, can inhibit the metastasis of mast cell tumor and has good antibacterial and antiviral effects;
the cantharis whole worm, cantharis is virulent, pungent and hot, have blood stasis breaking, stasis removing, stagnation dissipating, decay eliminating, toxic material counteracting, sore-removing efficacy, it is suitable for stubborn tinea, wart, malignant sore, dead muscle, etc. to use externally, its chemical composition is mainly cantharidin and derivant, cantharidin has stronger irritation to the mucosa of skin, can cause the local to become red and bubble, but its penetrating power to tissue is smaller, does not involve the deep layer of skin, the blister formed is fully healed very fast without leaving the scar, because cantharidin can stimulate macrophage to produce abundantly while foaming, therefore utilize this characteristic to treat many diseases.
Kuh-seng, bitter in taste and cold in nature, is externally used for killing parasites and relieving itching, and is used for treating eczema, mange, leprosy and other symptoms; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
rhubarb, radix et rhizoma Rhei, bitter in flavor and cold in nature, has the effects of removing food retention, clearing damp-heat, purging fire, cooling blood, removing blood stasis and detoxifying, and can be used for treating pyocutaneous disease and pyogenic infections by external application.
Borneol, being pungent, bitter and cool in nature and flavor, is externally used for sore and swelling disease without healing after ulceration, and has the functions of clearing away heat and toxic material, preventing corrosion and promoting granulation.
Salicylic acid has the functions of sterilization, inflammation diminishing and cutin removing, and is a common component of chemical external drugs.
Menthol, which is used as an irritant in medicine, acts on the skin or mucous membrane to cool and relieve itching.
The prescription fully considers the pharmacodynamics characteristics of each component, adopts the Chinese stellera root with the functions of dissipating stagnation and resisting bacteria, the lightyellow sophora root with the bitter taste and cold property and the functions of killing parasites and relieving itching and the rhubarb with the functions of purging intense heat, cooling blood, removing stasis and detoxifying, utilizes the cytotoxicity and the foaming characteristics of cantharidin, combines the cutin removing and inflammation diminishing characteristics of salicylic acid, can fully remove the thick scab of intractable neurodermatitis, better controls the concentration of the cantharidin, has smaller stimulation degree, is assisted with the menthol with the functions of cooling and relieving itching, and makes the affected part feel cool and comfortable after being applied.
The used medicine has good effects of inhibiting and removing skin lichenification, and has the effects of relieving itching, diminishing inflammation, removing blood stasis, detoxifying and the like, and the medicines are used together to directly reach the pathological change part, thereby fully playing the curative effect.
Example 2
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 11-13 parts of blister beetle, 45-55 parts of salicylic acid and 3-5 parts of menthol, and clinical comparison data prove that the proportioning is reasonable.
Example 3
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 47 parts of radix euphorbiae lantu, 47 parts of radix sophorae flavescentis, 18 parts of rheum officinale, 22 parts of borneol, 11 parts of cantharis whole worm, 45 parts of salicylic acid and 3 parts of menthol.
Example 4
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 53 parts of radix euphorbiae lantu, 53 parts of radix sophorae flavescentis, 22 parts of rheum officinale, 28 parts of borneol, 13 parts of cantharis whole worm, 55 parts of salicylic acid and 5 parts of menthol.
Example 5
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 53 parts of radix euphorbiae lantu, 53 parts of radix sophorae flavescentis, 22 parts of rheum officinale, 22 parts of borneol, 11 parts of cantharis scorpion, 45 parts of salicylic acid and 3 parts of menthol.
Example 6
A traditional Chinese medicine composition for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 40 parts of radix sophorae flavescentis, 40 parts of rheum officinale, 25 parts of borneol, 12 parts of cantharis whole worm, 50 parts of salicylic acid and 4 parts of menthol.
Example 7
The dosage form of the Chinese medicinal composition of any one of embodiments 1 to 6 may be a tincture, an ointment, a plaster, a gel or a patch. The Chinese medicinal composition can be prepared into various dosage forms, and is suitable for different conditions.
Example 8
The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract. The ethanol can dissolve sebum, loosen epidermis, and absorb water in skin. The ethanol also has effects of relaxing muscles and tendons, promoting blood circulation, dilating peripheral blood vessel, enhancing permeability of peripheral blood vessel, and promoting drug absorption, so as to exert pharmacological effect of the drugs in the medicated liquor. Meanwhile, the alcohol has the functions of disinfection, sterilization and itching relief.
The ointment is a semisolid external preparation with certain consistency prepared by uniformly mixing a medicament and a proper matrix. The common base is divided into oleaginous, water-soluble and emulsion base, wherein the ointment prepared from the emulsion base and easy to be coated is called cream.
Plasters are preparations which are sticky and which are intended for external application. Is prepared by mixing the medicine and proper matrix. Is usually uniformly coated on cotton cloth or other backing materials, and sometimes a plurality of small holes are arranged on the surface of the backing material. After being attached to the skin, the patch gradually exerts the drug effect at the body temperature. Common uses include adhesive plaster (i.e. adhesive plaster) and plaster (e.g. wound plaster).
The gel is thick liquid or semisolid preparation prepared by the drug and auxiliary materials capable of forming gel and prepared into solution, suspension or emulsion. Gels are typically topically applied to the skin and body cavities (e.g., nasal, vaginal, and rectal). Emulsion type gelling agents are also known as emulsors. Gelling agents made from a polymeric matrix (e.g., tragacanth, etc.) may also be referred to as mucilages. A gel formed by small particles of a small-molecular inorganic drug (such as aluminum hydroxide) existing in a liquid in a network structure belongs to a two-phase dispersion system and is also called a suspension type gel. Suspension gels can be thixotropic, semi-solid at rest and liquid when stirred or shaken.
The patch is a sheet-like preparation which can be adhered to the skin and the medicine can produce systemic or local effect. Modern transdermal absorption preparation is a patch or a patch medicine which is absorbed through skin, can quickly and durably enter the whole body according to the dosage required by the disease condition through a controlled release mechanism.
The Chinese medicinal composition can be made into various dosage forms, and is suitable for different disease occurrence positions and disease development stages.
Example 9
A traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following raw materials in parts by weight: 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 25g of borneol, 12g of cantharides whole worm, 50g of menthol, 4g of 75% ethanol and 1200ml of water, wherein the 75% ethanol is used for disinfection. Because too high a concentration of alcohol forms a protective film on the surface of bacteria to prevent it from entering the body of bacteria, it is difficult to kill bacteria thoroughly. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body can not be coagulated, and the bacteria can not be completely killed, and 75% ethanol is suitable for disinfection. The medication basis is as follows:
the Chinese stellera root has the effects of dissipating stagnation and killing insects, is externally used for skin itch, psoriasis and the like, contains gallic acid and derivatives thereof in chemical components, and has the current pharmacodynamic research that the gallic acid has the effects of resisting inflammation, mutation and tumor, can inhibit the metastasis of mast cell tumor and has good antibacterial and antiviral effects;
the cantharis whole worm, cantharis is virulent, pungent and hot, have blood stasis breaking, stasis removing, stagnation dissipating, decay eliminating, toxic material counteracting, sore-removing efficacy, it is suitable for stubborn tinea, wart, malignant sore, dead muscle, etc. to use externally, its chemical composition is mainly cantharidin and derivant, cantharidin has stronger irritation to the mucosa of skin, can cause the local to become red and bubble, but its penetrating power to tissue is smaller, does not involve the deep layer of skin, the blister formed is fully healed very fast without leaving the scar, because cantharidin can stimulate macrophage to produce abundantly while foaming, therefore utilize this characteristic to treat many diseases.
Kuh-seng, bitter in taste and cold in nature, is externally used for killing parasites and relieving itching, and is used for treating eczema, mange, leprosy and other symptoms; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
rhubarb, radix et rhizoma Rhei, bitter in flavor and cold in nature, has the effects of removing food retention, clearing damp-heat, purging fire, cooling blood, removing blood stasis and detoxifying, and can be used for treating pyocutaneous disease and pyogenic infections by external application.
Borneol, being pungent, bitter and cool in nature and flavor, is externally used for sore and swelling disease without healing after ulceration, and has the functions of clearing away heat and toxic material, preventing corrosion and promoting granulation.
Salicylic acid has the functions of sterilization, inflammation diminishing and cutin removing, and is a common component of chemical external drugs.
Menthol, which is used as an irritant in medicine, acts on the skin or mucous membrane to cool and relieve itching.
The prescription fully considers the pharmacodynamics characteristics of each component, adopts the Chinese stellera root with the functions of dissipating stagnation and resisting bacteria, the lightyellow sophora root with the bitter taste and cold property and the functions of killing parasites and relieving itching and the rhubarb with the functions of purging intense heat, cooling blood, removing stasis and detoxifying, utilizes the cytotoxicity and the foaming characteristics of cantharidin, combines the cutin removing and inflammation diminishing characteristics of salicylic acid, can fully remove the thick scab of intractable neurodermatitis, better controls the concentration of the cantharidin, has smaller stimulation degree, is assisted with the menthol with the functions of cooling and relieving itching, and makes the affected part feel cool and comfortable after being applied.
The used medicine has good effects of inhibiting and removing skin lichenification, and has the effects of relieving itching, diminishing inflammation, removing blood stasis, detoxifying and the like, and the medicines are used together to directly reach the pathological change part, thereby fully playing the curative effect.
Example 10
A Chinese medicinal tincture for treating intractable neurodermatitis:
50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rhubarb, 40g of cantharis, 12g of borneol, 25g of salicylic acid, 50g of menthol, 4g of 1200ml of 75% ethanol
A method for preparing a Chinese medicinal tincture for treating intractable neurodermatitis comprises pulverizing radix Euphorbiae Fischerianae 50g, radix Sophorae Flavescentis 40g, radix et rhizoma Rhei 40g, and Mylabris Scorpio 12g, sieving with 100 mesh sieve to obtain fine powder, adding Mentholum 4g, Borneolum Syntheticum 20g and salicylic acid 50g, soaking in 1200ml 75% ethanol for 10 days, stirring for several times, filtering, and packaging in glass bottles.
Example 11
A Chinese medicinal tincture for treating intractable neurodermatitis:
a Chinese medicinal tincture for treating intractable neurodermatitis is prepared by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris Scorpio into fine powder, sieving with 100-mesh sieve and 200-mesh sieve, adding Mentholum, Borneolum Syntheticum and salicylic acid, heating in 1200ml 75% ethanol round-bottom flask (with condenser at the upper end of the round-bottom flask) at 50 deg.C for 10 days, stirring for several times, vacuum filtering, and packaging in glass bottles.
Sieving with 100-200 mesh sieve means sieving with one or more of 100, 120, 140, 170, 200 mesh sieves
Example 12:
a Chinese medicinal tincture for treating intractable neurodermatitis:
100g of radix euphorbiae lantu, 100g of radix sophorae flavescentis, 100g of rheum officinale, 80g of borneol, 50g of cantharides whole worm, 22g of salicylic acid, 100g of menthol, 8g of 75% ethanol and 2400ml
The method for preparing the tincture of the traditional Chinese medicine composition for treating the intractable neurodermatitis comprises the following steps: pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, and Mylabris Scorpio into fine powder, sieving with 100 mesh sieve, sieving with 120 mesh sieve to obtain fine powder, adding Mentholum, Borneolum Syntheticum and salicylic acid, adding into 2400ml round-bottom flask with 75% ethanol, installing reflux device, refluxing at 78 deg.C for 72 hr, filtering, and packaging in glass bottles.
Example 13
A traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, Mentholum, Borneolum Syntheticum, Mylabris Scorpio, salicylic acid, caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, herba Erigerontis, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, Bulbus Lilii, and 75% ethanol.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
A Chinese medicinal tincture for treating intractable neurodermatitis is prepared by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, Mylabris Scorpio, Borneolum Syntheticum, caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, flos Hibisci, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, and Bulbus Lilii into fine powder, sieving with 100 mesh sieve, mixing with Mentholum, Borneolum Syntheticum and salicylic acid, soaking in 1200ml 75% ethanol for 10 days, stirring for several times, filtering, and bottling. The preparation is simple and easy to realize.
Example 14
A traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 11-13 parts of cantharis whole worm, 22-28 parts of borneol, 45-55 parts of salicylic acid, 3-5 parts of menthol, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily, and 1200 parts of 75% ethanol.
Clinical comparative data prove that the proportioning setting is reasonable.
A method for preparing a traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the steps of crushing 45-55 parts of radix euphorbiae lantu, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 11-13 parts of whole cantharis worm, 1-3 parts of borneol, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily into fine powder, sieving the fine powder with a 100-mesh sieve to obtain fine powder, adding menthol, borneol and salicylic acid into the fine powder, uniformly mixing, putting the fine powder into 1200 parts of 75% ethanol, soaking for 10 days, stirring for multiple times in the middle, carrying. The preparation is simple and easy to realize.
Example 15
A traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following raw material medicines in parts by mass: 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of cantharides whole worm, 25g of borneol, 50g of salicylic acid, 4g of menthol, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe, 1g of rosemary and 1200ml of 75% ethanol.
A method for preparing a traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the steps of crushing 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of blister beetle, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe and 1g of rosemary into fine powder, sieving the fine powder with a 100-mesh sieve, mixing the fine powder with 4g of menthol, 20g of borneol and 50g of salicylic acid uniformly, putting the mixture into 1200ml of 75% ethanol, soaking for 10 days, stirring for multiple times in the middle, carrying out suction filtration, and subpackaging in glass bottles for later use. The preparation is simple and easy to realize.
Example 16
The use method of the traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following steps:
applied to the affected part twice a day with cotton bud.
Clinical observations
1 clinical data
1.1 general data
On the premise of informed consent, 90 cases of intractable neurodermatitis patients, 51 cases of men and 39 cases of women, which meet the Tunne standard and exclusion standard in the XX hospital during the 9 th month to the 12 th month in 2019; the ages were 20-76 years, with the average (38.26 s 4.17) year. The Chinese herbal medicines are numbered in turn according to the sequence of the people's houses and are randomly divided into three groups of 30 cases. The general data of each group, namely sex, age, course of disease and difference of score of major symptoms, have no statistical significance P >0.05) and are comparable.
1.2 methods
The first treatment group: the traditional Chinese medicine formula tincture (the traditional Chinese medicine composition tincture for treating intractable neurodermatitis) is used for treatment, and is externally applied to an affected part for 4 weeks, wherein the traditional Chinese medicine formula tincture comprises the following raw material medicines, by mass, 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of cantharis whole worm, 25g of borneol, 50g of salicylic acid, 4g of menthol and 1200ml of 75% ethanol.
The second treatment group: the traditional Chinese medicine formula tincture (a traditional Chinese medicine composition tincture for treating intractable neurodermatitis) is used for treating and is externally applied to an affected part, and the tincture is applied once in the morning and at night for 4 weeks continuously, wherein the tincture comprises the following raw material medicines, by mass, 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of blister beetle, 25g of borneol, 50g of salicylic acid, 4g of menthol, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe, 1g of rosemary and 1200ml of 75% ethanol.
The control group is treated by Tacrolimus ointment (Astellas Toyama Co., Ltd. Toyama Plant, Chinese medicine standard J20100016), applied to affected part once in the morning and at night for 4 weeks, and simultaneously self-enhanced disease management is carried out, skin protection is well carried out, and solarization is avoided.
Three groups of patients were cured and followed for 3 months and observed for relapse rates.
3 analysis of therapeutic effects
3.1 Observation index
The main symptoms and signs including pruritus, pimple and moss before treatment, during treatment and after stopping the drug for 2 weeks are observed and recorded according to 0-3 grade scoring method from none, light, medium and heavy. 0 min to 4 min. ② the cure rate, the total effective rate and the adverse reaction of each group of patients after stopping taking the medicine for 2 weeks are compared. And thirdly, comparing the healing time of the skin lesion, the disappearance time of symptoms and the 3-month recurrence rate of the patients.
3.2 therapeutic criteria
Integral reduction index (%) — (total integral of pre-treatment cardinal signs-total score of post-treatment cardinal signs)/total integral of pre-treatment cardinal signs x 100%. The total effective rate is curing, obvious effect and improvement.
The pruritus, the pimple and the moss disappear completely;
the pruritus, the pimple and the moss basically disappear, and the integral drop index is more than equal 60 percent;
the improvement is that the itch, the pimple and the moss basically disappear and relieve, and the integral reduction index is more than or equal to 30 percent and less than 60 percent;
the skin itch, pimple and moss basically disappear, are not relieved or even aggravated, and the integral drop index is less than 30 percent.
3.3 statistical methods
Processing with SPSS 18.0, and t-testing the measured data
Representing, counting data by x2Inspection, P<A difference of 0.05 is statistically significant.
3.4 therapeutic results
All 90 patients in the group are successfully tested and treated, and no obvious adverse reaction occurs in three groups of patients. 3.4.1 the cure rate and total effective rate of three groups of patients after stopping taking the medicine for 2 weeks are compared (see Table 1)
The results show that the cure rates of the first treatment group, the second treatment group and the control group are respectively 66.67%, 70.00% and 50.00%, the total effective rates are respectively 100%, 100% and 83.33%, and the clinical curative effects of the first treatment group and the second treatment group are better than those of the control group. However, the difference between the first treatment group and the second treatment group was not statistically significant. The clinical efficacy of the first treatment group and the second treatment group was superior to that of the control group, but the difference between the A treatment group and the second treatment group was not statistically significant.
Table 1 three groups of comparative examples of clinical efficacy (%)
3.4.2 comparison of healing time of rash, disappearance time of symptom and recurrence rate of follow-up 3 months for each group of patients (see Table 2)
The healing time of the rash, the symptom disappearance time and the recurrence rate of the patients cured in the first treatment group and the second treatment group are respectively lower than those of the control group, the differences have statistical significance (P is less than 0.05), and the differences between the first treatment group and the second treatment group by the soil indexes have no statistical significance. The three groups of relapsing patients still have effective treatment by simply using traditional Chinese medicine external washing, while the traditional Chinese medicine treatment curative effect of the first treatment group and the second treatment group of relapsing patients is obviously better than that of a control group, but the re-grouping contrast study cannot be carried out because the total sample amount of the relapsing patients is less.
TABLE 2 comparison of healing time, symptom disappearance time and follow-up 3 month recurrence rate
At present, western medicines still have a plurality of defects in the aspect of antifungal treatment, and researches show that the traditional Chinese medicine has unique curative effects in the aspect of intractable neurodermatitis, no matter the traditional Chinese medicine is a single medicine or an effective component of the traditional Chinese medicine, or a compound preparation. The treatment method comprises external treatment, internal treatment and combination treatment, and the simple external treatment is suitable for patients with initial onset and limited focus.
The data show that the traditional Chinese medicine formula tincture of the first treatment group (the traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises the following bulk drugs of, by mass, 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of whole cantharis, 25g of borneol, 50g of salicylic acid, 4g of menthol and 1200ml of 75% ethanol) and the traditional Chinese medicine formula tincture of the second treatment group (the traditional Chinese medicine composition tincture for treating intractable neurodermatitis comprises, by mass, 50g of radix euphorbiae lantu, 40g of radix sophorae flavescentis, 40g of rheum officinale, 12g of whole cantharis, 25g of borneol, 50g of salicylic acid, 4g of menthol, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe, 1g of rosemary and 1200ml of 75% ethanol) are fully combined according to the pharmacodynamics characteristics of each component, the antibacterial radix euphorbiae lantu, the lightyellow sophora root which is bitter in taste and cold in nature and can kill parasites and relieve itching, and the rhubarb which has the effects of purging intense heat, cooling blood, removing stasis and detoxifying are adopted, the cytotoxicity and the bubbling characteristics of cantharidin are utilized, the cutin removing and inflammation diminishing characteristics of salicylic acid are combined, thick scabs of intractable neurodermatitis can be fully removed, the concentration of cantharidin is well controlled, the irritation degree is low, and the menthol which has the effects of cooling and relieving itching is used as an auxiliary material, so that the affected part feels cool and comfortable after being applied. The used medicine has good effects of inhibiting and removing skin lichenification, and has the effects of relieving itching, diminishing inflammation, removing blood stasis, detoxifying and the like, and the medicines are used together to directly reach the pathological change part, thereby fully playing the curative effect.
The embodiments of the present invention have been described in detail, but the present invention is only the preferred embodiments of the present invention, and is not to be considered as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating intractable neurodermatitis is characterized by comprising the following raw material medicines: radix Euphorbiae Fischerianae, Mylabris Scorpio, radix Sophorae Flavescentis, radix et rhizoma Rhei, Borneolum Syntheticum, salicylic acid, and Mentholum.
2. The traditional Chinese medicine composition for treating intractable neurodermatitis according to claim 1, which is characterized by comprising the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 11-13 parts of cantharis whole worm, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 45-55 parts of salicylic acid and 3-5 parts of menthol.
3. The traditional Chinese medicine composition for treating intractable neurodermatitis according to claim 2, which is characterized by comprising the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 12 parts of blister beetle, 40 parts of radix sophorae flavescentis, 40 parts of rheum officinale, 25 parts of borneol, 50 parts of salicylic acid and 4 parts of menthol.
4. The traditional Chinese medicine composition for treating intractable neurodermatitis according to claim 1, which is characterized by further comprising one or more of ivy, fructus kochiae, salvia miltiorrhiza, angelica sinensis, erigeron breviscapus, bergamot, aloe, rosemary, folium artemisiae argyi and lily.
5. The traditional Chinese medicine composition for treating intractable neurodermatitis according to claim 4, which is characterized by comprising the following raw material medicines in parts by mass: 45-55 parts of radix euphorbiae lantu, 11-13 parts of cantharides whole worm, 36-44 parts of radix sophorae flavescentis, 36-44 parts of rheum officinale, 22-28 parts of borneol, 45-55 parts of salicylic acid and 3-5 parts of menthol, wherein the composition comprises one or more of 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily.
6. The traditional Chinese medicine composition for treating intractable neurodermatitis according to any one of claims 1 to 5, wherein the dosage form of the traditional Chinese medicine composition is tincture, ointment, plaster, gel or patch.
7. Use of the Chinese medicinal composition for treating intractable neurodermatitis according to any one of claims 1 to 5 in the preparation of a medicament for treating intractable neurodermatitis, dermatitis or keratoderma.
8. The tincture containing the traditional Chinese medicine composition for treating intractable neurodermatitis of claim 6, which is characterized by further comprising 75% ethanol.
9. The method for preparing the traditional Chinese medicine composition for treating intractable neurodermatitis as claimed in claims 1-5 is characterized in that radix euphorbiae lantu, cantharis whole worm, radix sophorae flavescentis and radix et rhizoma rhei are pulverized, sieved by a 100-mesh sieve to form fine powder, then added with menthol, borneol and salicylic acid, and uniformly mixed to obtain the traditional Chinese medicine composition.
10. The method for preparing the tincture of Chinese medicinal composition for treating intractable neurodermatitis as claimed in claim 8, wherein the tincture is prepared by pulverizing radix Euphorbiae Fischerianae, Mylabris Scorpio, radix Sophorae Flavescentis, and radix et rhizoma Rhei, sieving with 100 mesh sieve to obtain fine powder, adding Mentholum, Borneolum Syntheticum and salicylic acid, soaking in 1300ml of 75% ethanol 1100-.
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Application publication date: 20210305 |