CN112369469A - Infant formula milk powder containing sialic acid and preparation method thereof - Google Patents
Infant formula milk powder containing sialic acid and preparation method thereof Download PDFInfo
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- CN112369469A CN112369469A CN201911121608.9A CN201911121608A CN112369469A CN 112369469 A CN112369469 A CN 112369469A CN 201911121608 A CN201911121608 A CN 201911121608A CN 112369469 A CN112369469 A CN 112369469A
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- sialic acid
- infant formula
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- 239000000843 powder Substances 0.000 title claims abstract description 150
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title claims abstract description 93
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title claims abstract description 92
- 235000013350 formula milk Nutrition 0.000 title claims abstract description 61
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- 239000008267 milk Substances 0.000 title claims abstract description 54
- 210000004080 milk Anatomy 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 33
- 239000000194 fatty acid Substances 0.000 claims abstract description 33
- 229930195729 fatty acid Natural products 0.000 claims abstract description 33
- -1 compound fatty acid Chemical class 0.000 claims abstract description 23
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 22
- 239000011707 mineral Substances 0.000 claims abstract description 22
- 235000013325 dietary fiber Nutrition 0.000 claims abstract description 21
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 21
- 239000000126 substance Substances 0.000 claims abstract description 21
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- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 7
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- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 7
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 6
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- 235000011147 magnesium chloride Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
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- 239000008101 lactose Substances 0.000 description 7
- 235000015097 nutrients Nutrition 0.000 description 7
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 6
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- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dairy Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the technical field of food processing, and particularly relates to sialic acid-containing infant formula milk powder and a preparation method thereof. The invention provides sialic acid-containing infant formula powder which comprises the following components in parts by weight: 3-8 parts of sialic acid, 5-15 parts of dietary fiber, 70-90 parts of milk powder, 1-8 parts of compound fatty acid, 0-8 parts of protein powder, 0-10 parts of mineral substances and 0-10 parts of sweetening agents. The sialic acid-containing infant formula milk powder provided by the invention is directly added with the sialic acid serving as a new food raw material, has the purity of 98%, is clear in components, high in safety and convenient to eat, is beneficial to quickly supplying nutrition, is beneficial to promoting the absorption of protein and fat of an infant, and prevents constipation.
Description
Technical Field
The invention belongs to the technical field of food processing, and particularly relates to sialic acid-containing infant formula milk powder and a preparation method thereof.
Background
Sialic Acid (SA), known by the scientific name "N-acetylneuraminic acid", is a naturally occurring carbohydrate. It was originally isolated from submandibular gland mucin and is therefore also known. Sialic acid is usually present in the form of oligosaccharides, glycolipids or glycoproteins. In humans, the brain has the highest sialic acid content. The content of sialic acid in the grey brain matter is 15 times that of internal organs such as liver and lung. The main food source of sialic acid is breast milk, which is also present in milk, eggs and cheese. It not only has the function of inducing invasive pathogenic bacteria, but also is currently recognized as a transmitter of ganglioside and is a component of the brain. Sialic acid can prevent pathogen invasion. Sialic acid is also a receptor for influenza virus, a binding site for influenza virus to bind in mucus cells.
Sialic acid is a nutrient necessary for cognitive development of human brain, and the supply of exogenous sialic acid can improve the concentration of ganglioside in animal brain and improve learning ability, especially the cognitive level. In infants' cognition, such as olfaction, hearing, touch, memory function and emotional occurrence, has already begun to develop during fetal life, during which sialic acid plays an important role in promoting brain development.
At present, the food with the function of supplementing sialic acid is mainly cubilose or food containing cubilose powder, but has the problems of inconvenient eating, low or undefined content, low purity and the like. However, the milk powder is a main energy and nutrition source of infants, so that the development of the infant milk powder which contains the nutritional ingredients required by the infants and is specially added with sialic acid is urgently needed, so that the effect of the product on the cognitive development of the brain is more prominent, and the nutritional requirements of the infants are further met. The sialic acid content of human milk was 1500mg/L at 250-1500mg/L, although some infant formulas were better similar to human milk, the sialic acid content of infant formulas was less than 200 mg/L. There is no relative standard for the amount of sialic acid added.
Chinese patent application CN103431051A discloses a dry preparation method of sialic acid-containing infant formula milk powder, which comprises the following steps: (1) peeling the raw materials; (2) adding 0-4.2g/kg of sialic acid into the raw materials and mixing; (3) and after uniformly mixing, collecting a product. Although the method can make up for the defect of insufficient sialic acid content in the infant formula in the prior art, the infant still has low absorption of nutrients in the milk powder and can also have the situations of constipation, diarrhea and the like.
Therefore, it is highly desirable to develop a nutritionally complete infant formula powder which can supplement sialic acid and promote the absorption of various nutrients by infants to prevent constipation and diarrhea in infants.
Disclosure of Invention
In order to solve the problems of the prior art, the present invention aims to provide an infant formula powder containing sialic acid and a preparation method thereof. The sialic acid-containing infant formula milk powder provided by the invention is directly added with the sialic acid serving as a new food raw material, has the purity of 98%, is clear in components, high in safety and convenient to eat, contributes to quick supply, is favorable for promoting the absorption of protein and fat of infants, and prevents constipation.
The technical scheme of the invention is as follows:
an infant formula powder containing sialic acid comprises the following components in parts by weight: 3-8 parts of sialic acid, 5-15 parts of dietary fiber, 70-90 parts of milk powder, 1-8 parts of compound fatty acid, 0-8 parts of protein powder, 0-10 parts of mineral substances and 0-10 parts of sweetening agents.
Further, the sialic acid-containing infant formula powder comprises the following components in parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of milk powder, 4 parts of compound fatty acid, 5 parts of protein powder, 5 parts of mineral substances and 6 parts of sweetening agent.
Further, the dietary fiber is one or more of fructo-oligosaccharide, galacto-oligosaccharide and stachyose.
Further, the milk powder is skimmed milk powder or whole milk powder; the protein powder is one or more of animal protein and plant protein.
Further, the compound fatty acid is composed of DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 1-5: 1-4: 5-8: 3-12.
Further, the compound fatty acid comprises DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 3:3:7: 10.
Further, the mineral substance is one or more of magnesium chloride, calcium gluconate and zinc gluconate.
Further, the sweetener is one or more of xylitol, stevioside and sucralose.
In addition, the invention also provides a preparation method of the infant formula powder containing sialic acid, which comprises the following preparation steps:
s1, screening sialic acid, dietary fibers, milk powder, compound fatty acid, protein powder, mineral substances and a sweetening agent by a 200-300-mesh sieve, then putting the materials into a mixer to be mixed for 10-20 minutes to ensure that the materials are uniformly dispersed, and after mixing, bagging and tying to obtain mixed milk powder;
s2, filling the mixed milk powder obtained in the step S2 into a can subjected to ultraviolet sterilization, and thus obtaining the milk powder.
Further, in the step S2, the sterilization treatment is performed for 60 to 90 seconds by using the ultraviolet irradiation time.
At present, the food with the function of supplementing sialic acid on the market is mainly cubilose or food containing cubilose powder, but the problems of inconvenient eating, low or indefinite content, low purity and the like exist.
The sialic acid-containing infant formula milk powder provided by the invention is added with substances such as medium-chain triglyceride powder, OPO structure fat powder and the like, so that the constipation and defecation difficulty of infants can be reduced, the infants can be helped to better absorb and digest nutrition, the possibility of calcium soap generation is effectively reduced, the softness of the excrement of the infants is increased, the occurrence probability of constipation is reduced, and the infants are prevented from getting inflamed.
Compared with the prior art, the infant formula powder containing sialic acid provided by the invention has the following advantages:
(1) the infant formula milk powder containing sialic acid provided by the invention is added with high-purity sialic acid, so that the problem of low sialic acid content is successfully solved; and the components have synergistic effect, so that the infant formula milk powder is beneficial to rapid supply, can improve the absorption of calcium, zinc and other nutrient substances by infants, and can prevent the problems of constipation and the like by matching with dietary fibers. The prepared finished milk powder has higher nutritive value, and the components in the milk powder have synergistic effect, so that the problem of incomplete supplement of nutrients of the basic milk powder can be solved, and the problem of adverse reaction caused by improper matching of the nutrients and the basic milk powder, insufficient or excessive nutrients due to blind supplement of the nutritional supplement by common consumers can be effectively avoided.
(2) According to the sialic acid-containing infant formula milk powder, the added compound fatty acid is composed of DHA algae oil powder, ARA algae oil powder, medium-chain triglyceride powder and OPO structure fat powder according to a certain proportion, all the components are synergistic synergistically, all the nutritional ingredients are easy to absorb by infants, the immunity of the infants can be improved, and the phenomena of getting inflamed, pulling the stomach, constipation and the like caused by dyspepsia are reduced.
Detailed Description
The present invention is further illustrated by the following description of specific embodiments, which are not intended to limit the invention, and various modifications and improvements can be made by those skilled in the art based on the basic idea of the invention, but the invention is within the protection scope of the invention.
Sialic acid was purchased from Shanghai Allantin Biotechnology GmbH and meets the requirements of the relevant quality standards in the national database of new food materials.
The other reagents are common reagents and can be purchased from conventional reagent production and sale companies.
EXAMPLE 1 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 3 parts of sialic acid, 5 parts of fructo-oligosaccharide, 70 parts of skimmed milk powder and 1 part of compound fatty acid.
Further, the compound fatty acid comprises DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 1:4:8: 12.
The preparation method of the infant formula milk powder containing sialic acid comprises the following preparation steps:
s1, screening sialic acid, fructo-oligosaccharide, skimmed milk powder and compound fatty acid through a 200-mesh sieve, then putting the sieved materials into a mixer to be mixed for 10 minutes to ensure that the materials are uniformly dispersed, and bagging and tying the materials after mixing to obtain mixed milk powder;
s2, filling the mixed milk powder obtained in the step S2 into a can subjected to ultraviolet sterilization, and thus obtaining the milk powder.
In step S2, the sterilization process is performed for 60 seconds of ultraviolet irradiation time.
EXAMPLE 2 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of whole milk powder, 4 parts of compound fatty acid, 5 parts of animal protein, 5 parts of mineral substances and 6 parts of sweetening agent.
The dietary fiber is composed of fructo-oligosaccharide, galacto-oligosaccharide and stachyose according to the weight ratio of 1:3: 6.
The composite fatty acid is composed of DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 3:3:7: 10.
The mineral substances comprise magnesium chloride, calcium gluconate and zinc gluconate according to the weight ratio of 1:1: 1.
The sweetening agent is composed of xylitol, stevioside and sucralose according to the weight ratio of 1:3: 2.
The preparation method of the infant formula milk powder containing sialic acid comprises the following preparation steps:
s1, screening sialic acid, dietary fibers, whole milk powder, compound fatty acid, animal protein, mineral substances and a sweetening agent through a 250-mesh sieve, then putting the materials into a mixer to be mixed for 15 minutes to ensure that the materials are uniformly dispersed, and bagging and tying after mixing to obtain mixed milk powder;
s2, filling the mixed milk powder obtained in the step S2 into a can subjected to ultraviolet sterilization, and thus obtaining the milk powder.
In step S2, the sterilization process is performed for an ultraviolet irradiation time of 80 seconds.
EXAMPLE 3 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 8 parts of sialic acid, 15 parts of dietary fiber, 90 parts of skimmed milk powder, 8 parts of compound fatty acid, 8 parts of vegetable protein, 10 parts of mineral substances and 10 parts of sweetening agent.
The composite fatty acid is composed of DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 5:1:5: 3.
The mineral calcium gluconate and the mineral zinc gluconate are mixed according to the weight ratio of 1: 1.
The sweetening agent is composed of stevioside and sucralose according to the weight ratio of 1: 1.
The preparation method of the infant formula powder containing sialic acid comprises the following preparation steps:
s1, sieving sialic acid, dietary fiber, skimmed milk powder, compound fatty acid, vegetable protein, mineral substances and a sweetening agent with a 300-mesh sieve, then putting into a mixer for mixing for 20 minutes to uniformly disperse the materials, and bagging and tying after mixing to obtain mixed milk powder;
s2, filling the mixed milk powder obtained in the step S2 into a can subjected to ultraviolet sterilization, and thus obtaining the milk powder.
In step S2, the sterilization process is performed with the ultraviolet irradiation time being 90 seconds.
Comparative example 1 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of whole milk powder, 4 parts of compound fatty acid, 5 parts of animal protein, 5 parts of mineral substances and 6 parts of sweetening agent.
The dietary fiber is composed of fructo-oligosaccharide, galacto-oligosaccharide and stachyose according to the weight ratio of 1:3: 6.
The composite fatty acid is composed of DHA algae oil powder, ARA algae oil powder and medium chain triglyceride powder according to the weight ratio of 3:3: 7.
The mineral substances comprise magnesium chloride, calcium gluconate and zinc gluconate according to the weight ratio of 1:1: 1.
The sweetening agent is composed of xylitol, stevioside and sucralose according to the weight ratio of 1:3: 2.
The preparation of the infant formula powder containing sialic acid is similar to that of example 2.
The difference from example 2 is that the OPO-structured lipid powder was not added to the complex fatty acid.
Comparative example 2 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of whole milk powder, 4 parts of compound fatty acid, 5 parts of animal protein, 5 parts of mineral substances and 6 parts of sweetening agent.
The dietary fiber is composed of fructo-oligosaccharide, galacto-oligosaccharide and stachyose according to the weight ratio of 1:3: 6.
The composite fatty acid is composed of DHA algae oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 3:7: 10.
The mineral substances comprise magnesium chloride, calcium gluconate and zinc gluconate according to the weight ratio of 1:1: 1.
The sweetening agent is composed of xylitol, stevioside and sucralose according to the weight ratio of 1:3: 2.
The preparation of the infant formula powder containing sialic acid is similar to that of example 2.
The difference from example 2 is that no ARA algal oil powder was added to the complex fatty acid.
Comparative example 3 an infant formula containing sialic acid
The sialic acid-containing infant formula milk powder comprises the following components in parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of whole milk powder, 4 parts of compound fatty acid, 5 parts of animal protein, 5 parts of mineral substances and 6 parts of sweetening agent.
The dietary fiber is composed of fructo-oligosaccharide, galacto-oligosaccharide and stachyose according to the weight ratio of 1:3: 6.
The composite fatty acid is composed of DHA algae oil powder, ARA algae oil powder, medium chain triglyceride powder and OPO structure fat powder according to the weight ratio of 1:1:1: 1.
The mineral substances comprise magnesium chloride, calcium gluconate and zinc gluconate according to the weight ratio of 1:1: 1.
The sweetening agent is composed of xylitol, stevioside and sucralose according to the weight ratio of 1:3: 2.
The preparation of the infant formula powder containing sialic acid is similar to that of example 2.
The difference from example 2 is that the complex fatty acid consists of DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder, OPO structural lipid powder in a weight ratio of 1:1:1: 1.
Test example I, animal absorption Performance simulation test
1. Test materials: infant formula powders containing sialic acid prepared in examples 1-3 and comparative examples 1-3.
2. Test subjects: 60 Kunming mice (male) with an average body weight of 20. + -. 0.05g were divided into 6 groups of 10 mice each.
3. The test method comprises the following steps:
(1) 6 groups of mice were fed with the sialic acid containing infant formula powders prepared in examples 1-3 and comparative examples 1-3, respectively, and after one week of acclimation, fasted for 48 hours during which water was freely available. Then, milk powder with a concentration of about 40% was quantitatively poured into each of 0.5mL, 10 of each group were slaughtered at a time point of 2 hours, the abdominal cavity was rapidly opened, the stomach and duodenum were taken out, and the small intestine was stored in an ice box.
(2) Determination of fat digestibility
Flushing the digestive tract with normal saline, collecting gastric juice and intestinal juice in normal saline, determining the fat content in each sample by an acid hydrolysis method, wherein the obtained fat content is the digestibility as compared with the total fat content of the gavage emulsion, and the calculation formula is as follows:
(3) determination of lactose digestibility
Flushing the digestive tract with normal saline, collecting gastric juice and intestinal juice in normal saline, determining the lactose content in each sample by a Rionene-Ke agricultural method, wherein the obtained lactose content is the digestibility compared with the total lactose content of the gavage emulsion, and the calculation formula is as follows:
(4) determination of protein digestibility
Flushing the digestive tract with normal saline, collecting gastric juice and intestinal juice in the normal saline, determining the protein content in each sample by a Kjeldahl method, wherein the obtained protein content is the digestibility compared with the total protein content of the gavage emulsion, and the calculation formula is as follows:
4. test results
The test results are shown in table 1.
TABLE 1 digestibility measurements
As can be seen from Table 1, the results of the digestibility tests of fat, lactose and protein of the infant formula powders containing sialic acid prepared in examples 1 to 3 are better than those of comparative examples 1 to 3, wherein the group of example 2 is the best example of the present invention. Compared with the test results of the example groups, the infant formula milk powder containing sialic acid has the advantages that the fat digestibility, the lactose digestibility and the protein digestibility are greatly reduced after the component proportion of the compound fatty acid is changed in the groups of the comparative examples 1 to 3, the components of the infant formula milk powder containing sialic acid are different, the synergistic effect is obvious, the infant formula milk powder containing sialic acid has higher fat digestibility, lactose digestibility and protein digestibility, and the absorption of the infant to nutrition can be better ensured.
Test example two, measurement of Effect of intestinal motility in mice
1. Test materials: infant formula powders containing sialic acid prepared in example 2 and comparative examples 1-3.
2. The test method comprises the following steps:
(1) and (3) grouping animals, namely taking 60 clean-grade Kunming mice, half male and half female, weighing 20-25g, and randomly dividing the mice into 6 groups, namely a normal control group, a model control group and 4 test groups, wherein each 10 groups comprise the mice.
(2) Preparing a model, namely injecting 2.5 mg/kg-day of morphine hydrochloride into mice of other groups except a normal control group subcutaneously for 5 days, wiping the tails of the mice by using a 75% alcohol cotton ball on the 1 st day to dilate blood vessels and engorge the blood, cutting off the tips of the mouse tails by 0.3cm, then immersing the mouse tail wounds into warm water at about 37 ℃ until the mice lose about 0.5ml of blood, and preparing the blood-deficiency constipation model.
(3) The administration method comprises the steps of performing intragastric administration of distilled water to mice of a normal control group and mice of a model control group at the same time of molding, and respectively performing intragastric administration to 8 mice of a test group to 6g/kg of body weight of the infant formula powder containing sialic acid, which is prepared in example 2 and comparative examples 1-3. Each group was administered 1 time per day for 5 consecutive days. In the last administration, 2% India ink indicator is added into distilled water and the medicinal liquid.
(4) Index observation, after the last administration, each group of mice was placed in a beaker with filter paper for observation, and the average time for discharging the 1 st black stool was recorded, and the total number of average stools and the average stool weight within 4 hours of the last administration were recorded.
3. Test results
The test results are shown in table 2.
Table 2 influence of formula milk powder of the present invention on intestinal motility of blood deficiency type constipation model mice
| Group of | Average defecation time (min) | Average number of defecation granules | Average stool weight (mg) |
| Normal control group | 99.8 | 16.2 | 228.9 |
| Model control group | 201.8 | 6.4 | 100.9 |
| Example 2 | 108.4 | 19.3 | 249.5 |
| Comparative example 1 | 159.8 | 11.2 | 152.3 |
| Comparative example 2 | 154.1 | 13.8 | 168.1 |
| Comparative example 3 | 148.6 | 15.7 | 145.9 |
As can be seen from Table 2, the defecation of the mouse in example 2 is better than that of the mice in comparative examples 1-3, which shows that the average defecation time is obviously longer than that of example 2 and the average defecation number and the weight of the excrement are greatly reduced after the components of the compound fatty acid are changed in the groups of comparative examples 1-3 of the invention, and the added compound fatty acid interacts with other components, so that the occurrence of constipation is effectively prevented.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. An infant formula powder containing sialic acid, which is characterized by comprising the following components in parts by weight: 3-8 parts of sialic acid, 5-15 parts of dietary fiber, 70-90 parts of milk powder, 1-8 parts of compound fatty acid, 0-8 parts of protein powder, 0-10 parts of mineral substances and 0-10 parts of sweetening agents.
2. The sialic acid containing infant formula of claim 1, which comprises the following components and parts by weight: 6 parts of sialic acid, 10 parts of dietary fiber, 80 parts of milk powder, 4 parts of compound fatty acid, 5 parts of protein powder, 5 parts of mineral substances and 6 parts of sweetening agent.
3. An infant formula powder containing sialic acid according to claim 1 or 2, wherein the dietary fibre is one or more of fructo-oligosaccharide, galacto-oligosaccharide, stachyose.
4. An infant formula containing sialic acid according to claim 1 or 2, wherein the milk powder is a skim milk powder or a whole milk powder; the protein powder is one or more of animal protein and plant protein.
5. The sialic acid containing infant formula powder of claim 1 or 2, wherein the complex fatty acid comprises DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder, and OPO-structured lipid powder in a weight ratio of 1-5: 1-4: 5-8: 3-12.
6. The sialic acid containing infant formula of claim 5, wherein the complex fatty acids consist of DHA algal oil powder, ARA algal oil powder, medium chain triglyceride powder, OPO structural lipid powder in a weight ratio of 3:3:7: 10.
7. The sialic acid containing infant formula of claim 1 or 2, wherein the mineral is one or more of magnesium chloride, calcium gluconate, and zinc gluconate.
8. An infant formula powder containing sialic acid according to claim 1 or 2, wherein the sweetener is one or more of xylitol, steviol glycosides, sucralose.
9. A process for the preparation of an infant formula powder containing sialic acid according to any of claims 1 to 8, wherein the preparation process comprises the following steps:
s1, screening sialic acid, dietary fibers, milk powder, compound fatty acid, protein powder, mineral substances and a sweetening agent by a 200-300-mesh sieve, then putting the materials into a mixer to be mixed for 10-20 minutes to ensure that the materials are uniformly dispersed, and after mixing, bagging and tying to obtain mixed milk powder;
s2, filling the mixed milk powder obtained in the step S2 into a can subjected to ultraviolet sterilization, and thus obtaining the milk powder.
10. The method of claim 9, wherein the step S2 is performed by sterilizing with ultraviolet radiation for 60 to 90 seconds.
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