CN111991475A - 一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶及其制备方法 - Google Patents
一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶及其制备方法。所述风湿骨病、颈肩腰腿痛的软膏凝胶，包括如下重量份原料：祖师麻提取物10～15份、闹羊花提取物10～15份、马钱子提取物10～15份、草乌提取物10～15份、骨碎补提取物10～15份、川乌提取物10～15份、乳香提取物6～10份、没药提取物6～10份、独活提取物6～10份、五加皮提取物6～10份、威灵仙提取物6～10份、细辛提取物6～10份和川续断提取物6～10份。所述原料组分配伍科学合理，能够针对性地祛风除湿、缓解疼痛；并可加速有效成分地吸收，持续消肿生肌，强筋壮骨，综合治疗效果极佳；所述制备方法工艺简单易控，有利于规模化生产。
Description
技术领域
本发明属于药物领域，具体涉及一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶及其制备方法。
背景技术
风湿骨病、颈肩腰腿痛多为慢性劳损及无菌性炎症引起的以病患部位疼痛，肿胀甚至功能受限为主的一组疾病。常见病包括：颈椎病，肩周炎，腱鞘炎，腰间盘突出，腰肌劳损，骨质增生等疾病。因起病比较隐蔽，症状不典型或疼痛时轻时重，有时甚至可自行缓解，因而不被广大患者所认识，从而错过了治疗的最佳时机。
常见的原因主要为：软组织急性损伤、软组织慢性劳损、风寒湿因素、过敏因素或免疫因素等。
现有的药物往往不能根治，治疗效果有限，故提出本发明的技术方案。
发明内容
为了解决现有技术存在的问题，本发明提供了一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶及其制备方法。所述原料组分配伍科学合理，能够针对性地祛风除湿、缓解疼痛；并可加速有效成分地吸收，持续消肿生肌，强筋壮骨，综合治疗效果极佳；所述制备方法工艺简单易控，有利于规模化生产。
本发明的方案是，提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶，包括如下重量份原料：祖师麻提取物10～15份、闹羊花提取物10～15份、马钱子提取物10～15份、草乌提取物10～15份、骨碎补提取物10～15份、川乌提取物10～15份、乳香提取物6～10份、没药提取物6～10份、独活提取物6～10份、五加皮提取物6～10份、威灵仙提取物6～10份、细辛提取物6～10份和川续断提取物6～10份。
优选地，所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶包括如下重量份原料：祖师麻提取物12.5份、闹羊花提取物12.5份、马钱子提取物12.5份、草乌提取物12.5份、骨碎补提取物12.5份、川乌提取物12.5份、乳香提取物8份、没药提取物8份、独活提取物8份、五加皮提取物8份、威灵仙提取物8份、细辛提取物8份和川续断提取物8份。
优选地，所述祖师麻提取物的制备方法包括如下步骤：
(1)取祖师麻原料烘干、切碎、研磨，得祖师麻粉；
(2)将步骤(1)所得祖师麻粉与水混合，回流提取后过滤，得一次滤液和一次滤渣；
(3)将步骤(2)所得一次滤渣与乙醇混合，二次回流提取后过滤，得二次滤液和二次滤渣；
(4)将一次滤液和二次滤液合并，再进行浓缩、蒸干，即得祖师麻提取物。
优选地，步骤(1)中，所述研磨至过80～120目网筛。
优选地，步骤(2)中，所述祖师麻粉与水的重量比为1:3～5；所述回流提取的温度为85～90℃，回流提取的时间为2～4h。
优选地，步骤(3)中，所述一次滤渣与乙醇的重量比为1:2～4；所述二次回流提取的温度为65～70℃，回流提取的时间为5～7h。
优选地，步骤(4)中，所述蒸干的温度为35～45℃。
本发明的再一方案是，提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，包括如下步骤：
(i)将原料进行混合，搅拌均匀后得原料混合粉；
(ii)将步骤(i)所得原料混合粉与基质混合制备成软膏凝胶即可。
优选地，步骤(i)中，所述混合的搅拌转速为60～80r/min。
优选地，步骤(ii)中，所述原料混合粉与基质的重量比为1:9～11。
特别说明的，本发明所述闹羊花提取物、马钱子提取物、草乌提取物、骨碎补提取物、川乌提取物的制备方法如下：
(1)将原料(闹羊花、马钱子、草乌、骨碎补或川乌)烘干、切碎、研磨，得原料粉；
(2)将原料粉与水混合，回流提取2～3次，再将每次提取液进行合并，减压蒸馏浓缩，并继续烘干至含水量低于5％即可。
而乳香提取物、没药提取物、独活提取物、五加皮提取物、威灵仙提取物、细辛提取物和川续断提取物的制备方法如下：
(a)将原料(乳香、没药、独活、五加皮、威灵仙、细辛或川续断)烘干、切碎、研磨，得原料粉；
(b)将原料粉先与乙醇混合回流提取，再与水混合回流提取，将两次提取液进行合并后，减压蒸馏浓缩，并继续烘干即可。
本发明再提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶的使用方法：将软膏凝胶均匀涂抹于患处和相应穴位，直至全部吸收；每天早晚各一次。
为了便于理解本发明，对本发明所用原料的功效及作用做进一步解释。
祖师麻：味辛、苦，性温；归心、肝经；具有祛风通络、散瘀止痛的功效；主治风湿痹痛、四肢麻木、头痛、胃痛、腰痛、跌打损伤等症状。
闹羊花：味辛，性温；归肝经；具有祛风除湿、散瘀定痛的功效；主治风湿痹痛、跌打损伤、皮肤顽癣等症状。
马钱子：味苦，性寒；归肝、脾经；具有散结消肿、通络止痛的功效；主治跌打损伤、骨折肿痛、痈疽疮毒、咽喉肿痛、风湿顽痹、麻木瘫痪等症状。
草乌：味辛、苦，性热；归心、肝、肾、脾经；具有祛风除湿、温经止痛的效果；主治风寒湿痹、关节疼痛、心腹冷痛等症状。
骨碎补：味苦，性温；归肝、肾经；具有补肾、活血、止血的功效；主治腰痛、风湿痹痛、齿痛、跌打闪挫、骨伤等症状。
川乌：味辛、苦，性热；归心、肝、肾、脾经；具有祛风除湿、温经止痛的功效；主治风寒湿痹、关节疼痛、心腹冷痛等症状。
乳香：味辛、苦，性温；归心、肝、脾经；具有活血行气止痛、消肿生肌的效果；主治胸痹心痛、风湿痹痛、筋脉拘挛、跌打损伤等症状。
没药：味辛、苦，性平；归心、肝、脾经；具有散瘀定痛、消肿生肌的效果；主治胸痹心痛、胃脘疼痛、风湿痹痛、跌打损伤等症状。
独活：味辛、苦，性微温；归肾、膀胱经；具有祛风除湿、通痹止痛的效果；主治风寒湿痹、腰膝疼痛、少阴伏风头痛、风寒挟湿头痛等症状。
五加皮：味辛、苦，性温；归肝、肾经；具有祛风湿、补益肝肾、强筋壮骨、利水消肿的效果；主治风湿痹病、筋骨痿软、体虚乏力等症状。
威灵仙：味辛、咸，性温；归膀胱经；具有祛风湿、通经络的效果；主治风湿痹痛、肢体麻木、筋脉拘挛、屈伸不利等症状。
细辛：味辛，性温；归心、肺、肾经；具有解表散寒、祛风止痛、通窍、温肺化饮的功效；主治头痛、牙痛、风湿痹痛等症状。
川续断：味苦、辛，微温性；具有补肝肾、强筋骨、续折伤、止崩漏的功效；主治脾肾亏虚，气阴不足等症状。
本发明的有益效果为：
1、本发明所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，原料组分配伍科学合理，其中：祖师麻提取物、闹羊花提取物、马钱子提取物、草乌提取物、川乌提取物、独活提取物、威灵仙提取物、细辛提取物能够针对性地祛风除湿，缓解疼痛；配合具有活血行气的骨碎补提取物和乳香提取物，能够使有效成分快速达到病灶并被吸收；考虑到伤痛难免会造成劳损，故添加没药提取物用以消肿生肌，可令患处恢复如初；为了增强治疗效果，所添加的五加皮提取物和川续断提取物能强筋壮骨、续折伤，能整体巩固肌体。
2、本发明所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，工艺简单易控，有利于规模化生产。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
实施例1
本实施例提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，包括如下步骤：
(I)制备祖师麻提取物，包括如下步骤：
(1)取祖师麻原料烘干、切碎、研磨，并过80目网筛，得祖师麻粉；
(2)将步骤(1)所得祖师麻粉与水按重量比为1:3混合，在85℃条件下回流提取2h后过滤，得一次滤液和一次滤渣；
(3)将步骤(2)所得一次滤渣与乙醇按重量比为1:2混合，在65℃条件下二次回流提取5h后过滤，得二次滤液和二次滤渣；
(4)将一次滤液和二次滤液合并，再进行浓缩，并于鼓风条件下35℃蒸干，即得祖师麻提取物。
(II)制备治疗风湿骨病、颈肩腰腿痛的软膏凝胶，包括如下步骤：
(i)将10g祖师麻提取物、10g闹羊花提取物、10g马钱子提取物、10g草乌提取物、10g骨碎补提取物、10g川乌提取物、6g乳香提取物、6g没药提取物、6g独活提取物、6g五加皮提取物、6g威灵仙提取物、6g细辛提取物和6g川续断提取物进行混合，于60r/min条件下搅拌均匀，得原料混合粉；
(ii)将步骤(i)所得原料混合粉与基质按1:9的重量比混合均匀，并制成软膏凝胶即可。
实施例2
本实施例提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，包括如下步骤：
(I)制备祖师麻提取物，包括如下步骤：
(1)取祖师麻原料烘干、切碎、研磨，并过120目网筛，得祖师麻粉；
(2)将步骤(1)所得祖师麻粉与水按重量比为1:5混合，在90℃条件下回流提取4h后过滤，得一次滤液和一次滤渣；
(3)将步骤(2)所得一次滤渣与乙醇按重量比为1:4混合，在70℃条件下二次回流提取7h后过滤，得二次滤液和二次滤渣；
(4)将一次滤液和二次滤液合并，再进行浓缩，并于鼓风条件下45℃蒸干，即得祖师麻提取物。
(II)制备治疗风湿骨病、颈肩腰腿痛的软膏凝胶，包括如下步骤：
(i)将15g祖师麻提取物、15g闹羊花提取物、15g马钱子提取物、15g草乌提取物、15g骨碎补提取物、15g川乌提取物、10g乳香提取物、10g没药提取物、10g独活提取物、10g五加皮提取物、10g威灵仙提取物、10g细辛提取物和10g川续断提取物进行混合，于80r/min条件下搅拌均匀，得原料混合粉；
(ii)将步骤(i)所得原料混合粉与基质按1:11的重量比混合均匀，并制成软膏凝胶即可。
实施例3
本实施例提供一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，包括如下步骤：
(I)制备祖师麻提取物，包括如下步骤：
(1)取祖师麻原料烘干、切碎、研磨，并过100目网筛，得祖师麻粉；
(2)将步骤(1)所得祖师麻粉与水按重量比为1:4混合，在88℃条件下回流提取3h后过滤，得一次滤液和一次滤渣；
(3)将步骤(2)所得一次滤渣与乙醇按重量比为1:3混合，在67℃条件下二次回流提取6h后过滤，得二次滤液和二次滤渣；
(4)将一次滤液和二次滤液合并，再进行浓缩，并于鼓风条件下40℃蒸干，即得祖师麻提取物。
(II)制备治疗风湿骨病、颈肩腰腿痛的软膏凝胶，包括如下步骤：
(i)将12.5g祖师麻提取物、12.5g闹羊花提取物、12.5g马钱子提取物、12.5g草乌提取物、12.5g骨碎补提取物、12.5g川乌提取物、8g乳香提取物、8g没药提取物、8g独活提取物、8g五加皮提取物、8g威灵仙提取物、8g细辛提取物和8g川续断提取物进行混合，于70r/min条件下搅拌均匀，得原料混合粉；
(ii)将步骤(i)所得原料混合粉与基质按1:10的重量比混合均匀，并制成软膏凝胶即可。
为了表明本发明所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶的效果，选取如下案例进行说明：
案例1：
刘某，男，45岁；刘先生腰突深受腰突困扰，在多家医院治疗一个多月，走路仍困难，需人搀扶。使用本发明所述软膏凝胶涂抹后背膀胱经到委中，之后按摩、正骨，第四天时腰突已经明显好转，又持续使用15天后，腰痛消失，但大腿后侧仍偶发僵硬隐痛，建议持续涂抹。
案例2：
李某，女，28岁；李女士坐月子期间无意间受风，致使脊背发凉、胳膊疼痛；使用本发明所述软膏凝胶涂抹至脊背、胳膊相应位置，约1星期后，李女士症状消失，即使吹空调也没有任何不适感。
案例3：
王某，女，45岁；王女士左膝关节半月板损伤已两年，双脚踝关节经常疼痛，走路及下楼梯困难；使用本发明所述软膏凝胶约1星期，疼痛有所缓解，持续使用2个月后疼痛消失，为巩固疗效，后续使用1个月。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，包括如下重量份原料：祖师麻提取物10～15份、闹羊花提取物10～15份、马钱子提取物10～15份、草乌提取物10～15份、骨碎补提取物10～15份、川乌提取物10～15份、乳香提取物6～10份、没药提取物6～10份、独活提取物6～10份、五加皮提取物6～10份、威灵仙提取物6～10份、细辛提取物6～10份和川续断提取物6～10份。
2.根据权利要求1所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，包括如下重量份原料：祖师麻提取物12.5份、闹羊花提取物12.5份、马钱子提取物12.5份、草乌提取物12.5份、骨碎补提取物12.5份、川乌提取物12.5份、乳香提取物8份、没药提取物8份、独活提取物8份、五加皮提取物8份、威灵仙提取物8份、细辛提取物8份和川续断提取物8份。
3.根据权利要求1或2所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，所述祖师麻提取物的制备方法包括如下步骤：
(1)取祖师麻原料烘干、切碎、研磨，得祖师麻粉；
(2)将步骤(1)所得祖师麻粉与水混合，回流提取后过滤，得一次滤液和一次滤渣；
(3)将步骤(2)所得一次滤渣与乙醇混合，二次回流提取后过滤，得二次滤液和二次滤渣；
(4)将一次滤液和二次滤液合并，再进行浓缩、蒸干，即得祖师麻提取物。
4.根据权利要求3所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，步骤(1)中，所述研磨至过80～120目网筛。
5.根据权利要求3所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，步骤(2)中，所述祖师麻粉与水的重量比为1:3～5；所述回流提取的温度为85～90℃，回流提取的时间为2～4h。
6.根据权利要求3所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，步骤(3)中，所述一次滤渣与乙醇的重量比为1:2～4；所述二次回流提取的温度为65～70℃，回流提取的时间为5～7h。
7.根据权利要求3所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶，其特征在于，步骤(4)中，所述蒸干的温度为35～45℃。
8.权利要求1～7任一所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，其特征在于，包括如下步骤：
(i)将原料进行混合，搅拌均匀后得原料混合粉；
(ii)将步骤(i)所得原料混合粉与基质混合制备成软膏凝胶即可。
9.根据权利要求8所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，步骤(i)中，所述混合的搅拌转速为60～80r/min。
10.根据权利要求8所述治疗风湿骨病、颈肩腰腿痛的软膏凝胶的制备方法，步骤(ii)中，所述原料混合粉与基质的重量比为1:9～11。
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| CN103520308A (zh) * | 2013-01-09 | 2014-01-22 | 席安胜 | 一种治疗腰、颈、肩、膝疼膏药的组方 |
| CN104189124A (zh) * | 2014-09-11 | 2014-12-10 | 洛阳民华生物科技有限公司 | 一种用于改善颈肩腰腿疼痛的中药药油及其制备方法 |
| CN108175784A (zh) * | 2017-12-29 | 2018-06-19 | 何泉宏 | 一种治风湿病的中药组合物及其药剂制备方法 |
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| CN1285196A (zh) * | 2000-08-28 | 2001-02-28 | 赵芳可 | 风寒湿痹证蠲痹膏 |
| CN101347520A (zh) * | 2007-07-20 | 2009-01-21 | 班倩 | 万安祛痛保健膏 |
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| CN108175784A (zh) * | 2017-12-29 | 2018-06-19 | 何泉宏 | 一种治风湿病的中药组合物及其药剂制备方法 |
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