CN111956526A - Eye patch and preparation method thereof - Google Patents
Eye patch and preparation method thereof Download PDFInfo
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- CN111956526A CN111956526A CN202011067470.1A CN202011067470A CN111956526A CN 111956526 A CN111956526 A CN 111956526A CN 202011067470 A CN202011067470 A CN 202011067470A CN 111956526 A CN111956526 A CN 111956526A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- Life Sciences & Earth Sciences (AREA)
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- Birds (AREA)
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Abstract
The invention relates to an eye patch, which comprises a substrate back lining layer, a binding layer and a hydrogel layer; the main components of the hydrogel layer comprise the following components: 8-12 parts of polysiloxane elastomer with the viscosity of 500-8000 Pa.S, 8-10 parts of sodium hyaluronate, 5-10 parts of poloxamer, 1-3 parts of auxiliary gel-sol agent, 1-2 parts of small molecular peptide, 5-8 parts of glycerol, 20-25 parts of graphene oxide modified water-soluble film-forming polymer, 2-4 parts of skin active ingredient and 30-40 parts of water. By using the polysiloxane elastomer with the viscosity of 500-8000Pa & S and the graphene oxide modified water-soluble film-forming polymer in the hydrogel for the eye patch, comfortable sensory experience of the eye patch can be obtained, and the eye patch is ensured to have excellent effects of moisturizing, whitening, removing wrinkles and the like.
Description
Technical Field
The invention belongs to the field of cosmetics, relates to an eye patch, and particularly relates to an eye patch with the effects of moisturizing, whitening, removing wrinkles and the like.
Background
Cosmetics are increasingly gaining attention from people, especially women, in the current society. This is because the skin is the first line of defense against external environmental insults and is also the outermost surface of the human body that exhibits its own aesthetic appearance with respect to the outside. Accordingly, in order to ensure the health protection and aesthetic appearance of the skin to the human body, the care of the skin including whitening, moisturizing, removing wrinkles, and the like, becomes important to the human body.
In modern life, various work activities and leisure and entertainment activities of human beings are directly related to an electronic display, people need to face the display with eyes for a long time, so that the skin near the eyes is easy to fatigue, and meanwhile, the skin can also be a breakthrough of the external environment invading the skin of the human body, so that the skin near the eyes firstly has the phenomena of fine lines, yellow spots, dryness, desquamation and the like.
In order to effectively care the eye skin, people develop an eye patch based on the improvement of a facial mask. However, the skin near the eyes has certain particularity, and the ordinary eye patch usually has an unsatisfactory effect of caring the skin of the eyes.
The skin near the eyes can be driven by blinking to do high-frequency stretching and shrinking movement, and after the common eye patch is pasted on the surface of the skin near the eyes, the situations of wrinkles, dehydration, nutrient loss and the like are easy to occur, so that the nursing effect is lower than expected.
To this end, the present invention seeks to provide an eye patch particularly suitable for skin surface care in the vicinity of the eyes.
Disclosure of Invention
In order to solve the technical problems in the existing eye patches, the invention provides an eye patch with excellent tiling effect and moisturizing and water locking effect.
An eye patch comprising a base backing layer, a binding layer, a hydrogel layer, wherein the hydrogel layer comprises the following constituents: 8-12 parts of polysiloxane elastomer, 8-10 parts of sodium hyaluronate, 5-10 parts of poloxamer, 1-3 parts of auxiliary gel-sol agent, 1-2 parts of small molecular peptide, 5-8 parts of glycerol, 20-25 parts of graphene oxide modified water-soluble film-forming polymer, 2-4 parts of skin active ingredient and 30-40 parts of water.
The graphene oxide modified water-soluble film-forming polymer is selected from one or more of graphene oxide modified polyethylene oxide polymer, graphene oxide modified polyvinyl alcohol copolymer, graphene oxide modified methyl cellulose, graphene oxide modified carboxymethyl cellulose, graphene oxide modified hydroxyethyl cellulose, graphene oxide modified hydroxypropyl methyl cellulose and graphene oxide modified starch. The graphene oxide modified water-soluble film-forming polymer can effectively lock moisture, and gather surrounding moisture and humidity near the eye patch area, so as to promote the absorption and utilization of moisture and skin active ingredients by the skin in the eye area.
The preparation method of the graphene oxide modified water-soluble film-forming polymer comprises the following steps:
(1) preparing a graphene oxide nanosheet dispersion liquid: dispersing graphene oxide nanosheets in deionized water with the concentration of 3-5g/L, and sequentially carrying out mechanical stirring and ultrasonic shearing to obtain a uniform dispersion liquid;
(2) preparing a water-soluble film-forming polymer aqueous solution, dissolving a water-soluble film-forming polymer to be modified in deionized water at a concentration of 50-80g/L, and mechanically stirring until the water-soluble film-forming polymer is completely dissolved;
(3) graphene oxide catalytic liquid: adding 1-2g of a catalyst into 1L of the graphene oxide nanosheet dispersion liquid in the step (1) to activate carboxyl groups on the surface of the graphene oxide, wherein the catalyst is at least one of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine and N-hydroxysuccinimide;
(4) and (3) mixing the water-soluble film-forming polymer aqueous solution obtained in the step (2) with the graphene oxide catalytic solution obtained in the step (3) according to the volume ratio of 1 (3-5), uniformly stirring, reacting at 40-50 ℃ for 3-4h, and dialyzing, filtering, washing and drying the product after complete reaction to obtain the graphene oxide modified water-soluble film-forming polymer.
Wherein the rotation speed of the mechanical stirring is 300-500r/min, and the stirring time is 20-30 min; the ultrasonic shearing time is 60-120min, and the ultrasonic frequency is 30-40 KHz.
According to the invention, the water-soluble film-forming polymer is modified by the graphene oxide, so that the water-soluble film-forming polymer can fully utilize the steric hindrance structure of the graphene group, and the aggregation and retention effects of the modified water-soluble polymer on water are promoted.
Generally, the average blink frequency of a person is about 15 blinks per minute, and one blink drives the skin in the local region of the eye to stretch and contract once, i.e. the local stretch and contraction of the skin near the eye is about 30 times per minute. The high frequency of local skin is tensile and the shrink can drive the corresponding stretch and shrink of surperficial skin pad pasting, and this can make the skin pad pasting produce the fold easily, can't keep permanent tiling effect, and the moisture in the skin pad pasting is discharged by the local extrusion force of tensile, shrink easily simultaneously. Therefore, a skin patch applied near the eyes is required to have excellent effects of spreading and moisturizing and water-locking.
The water-soluble film-forming polymer modified by the graphene oxide has excellent water-locking and moisturizing effects, and can meet the application requirements of eye patches.
Further, the eye patch of the present invention uses a silicone elastomer, wherein the viscosity of the silicone elastomer is preferably about 500-8000 Pa.S. As for the viscosity of the silicone elastomer, when the viscosity is less than 500Pa · S, there is a defect that a good moisturizing effect cannot be provided; when the viscosity is more than 8000Pa · S, the eye patch cannot be spread evenly, the sensory experience after the patch is stuck is poor, and the active ingredients in the eye patch cannot be released effectively.
Further, the bonding layer is selected from one or more of ethyl vinyl acetate, acrylate, methacrylate, urethane, polyisobutylene, polystyrene-isoprene copolymer, polystyrene-butadiene copolymer, polybutadiene
Further, the auxiliary gel-sol agent is selected from one or more of laureth, oleyl polyether, fatty alcohol polyether, glyceryl stearate and glyceryl oleate.
Further, the skin active ingredients comprise one or more of freckle removing ingredients, whitening ingredients, moisturizing ingredients, wrinkle removing ingredients and moisturizing ingredients.
In addition, the sodium hyaluronate is used in the hydrogel layer of the eye patch, so that the biocompatibility of the eye patch and eye skin can be improved, and the sensory experience effect after the eye patch is attached can be improved. By using the poloxamer, the slow-release effect of the hydrogel can be improved, so that water and skin active ingredients in the hydrogel are slowly released, and the hydrogel is beneficial to full absorption and utilization of skin. A small amount of small molecular peptides can relieve the fatigue of eye skin, improve the skin activity and promote the improvement of the skin care effect of hydrogel.
Detailed Description
The present invention will be described in detail below with reference to specific examples. The following examples are described based on representative embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples. Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, devices, and steps that are well known to those skilled in the art have not been described in detail so as not to obscure the present invention.
Example 1
Firstly, a graphene oxide modified water-soluble film-forming polymer is prepared, in this embodiment, only graphene oxide modified hydroxyethyl cellulose is taken as an example for illustration, and in a specific application, graphene oxide modified hydroxyethyl cellulose may be replaced with other graphene oxide modified water-soluble film-forming polymer in the present invention.
The specific preparation steps of the graphene oxide modified hydroxyethyl cellulose are as follows:
(1) preparing a graphene oxide nanosheet dispersion liquid: dispersing graphene oxide nanosheets in deionized water, wherein the concentration of the graphene oxide nanosheets is 5g/L, and sequentially carrying out mechanical stirring for 30min at the rotating speed of 400r/min and ultrasonic shearing for 90min at the ultrasonic frequency of 35KHz to obtain uniform dispersion liquid;
(2) preparing a water-soluble film-forming polymer aqueous solution, dissolving hydroxyethyl cellulose in deionized water at a concentration of 60g/L, and mechanically stirring until the hydroxyethyl cellulose is completely dissolved;
(3) graphene oxide catalytic liquid: adding 2g of catalyst N-hydroxysuccinimide into 1L of graphene oxide nanosheet dispersion liquid obtained in the step (1) to activate carboxyl on the surface of graphene oxide;
(4) and (3) mixing the water-soluble film-forming polymer aqueous solution obtained in the step (2) and the graphene oxide catalytic solution obtained in the step (3) according to the volume ratio of 1:4, uniformly stirring, reacting at 60 ℃ for 4 hours, and dialyzing, filtering, washing and drying a product after complete reaction to obtain the graphene oxide modified hydroxyethyl cellulose.
A hydrogel was then prepared, which in this example had the composition: 10 parts of polydimethylsiloxane with the viscosity of about 2000Pa & S, 10 parts of sodium hyaluronate, 8 parts of poloxamer, 2 parts of glyceryl stearate, 2 parts of small molecular peptide, 6 parts of glycerol, 22 parts of graphene oxide modified hydroxyethyl cellulose, 2 parts of a whitening component, 2 parts of a water supplementing component and 36 parts of water.
And finally, preparing the eye patch, namely forming an ethyl vinyl acetate layer on the surface of the substrate backing layer, and then forming the hydrogel layer on the surface of the ethyl vinyl acetate layer to obtain the eye patch consisting of the substrate backing layer, the binding layer and the hydrogel layer.
Example 2
Firstly, a graphene oxide modified water-soluble film-forming polymer is prepared, in this embodiment, only graphene oxide modified starch is taken as an example for illustration, and in a specific application, the graphene oxide modified starch may be replaced with other graphene oxide modified water-soluble film-forming polymers in the present invention.
The specific preparation steps of the graphene oxide modified starch are as follows:
(1) preparing a graphene oxide nanosheet dispersion liquid: dispersing graphene oxide nanosheets in deionized water, wherein the concentration of the graphene oxide nanosheets is 6g/L, and sequentially carrying out mechanical stirring for 30min at the rotating speed of 400r/min and ultrasonic shearing for 90min at the ultrasonic frequency of 35KHz to obtain uniform dispersion liquid;
(2) preparing a water-soluble film-forming polymer aqueous solution, dissolving starch in deionized water at a concentration of 50g/L, and mechanically stirring until the starch is completely dissolved;
(3) graphene oxide catalytic liquid: adding 2g of catalyst 1-ethyl- (3-dimethylaminopropyl) carbonyldiimine hydrochloride into 1L of graphene oxide nanosheet dispersion liquid in the step (1) to activate carboxyl on the surface of graphene oxide;
(4) and (3) mixing the water-soluble film-forming polymer aqueous solution obtained in the step (2) and the graphene oxide catalytic solution obtained in the step (3) according to the volume ratio of 1:3, uniformly stirring, reacting at 40 ℃ for 4 hours, and dialyzing, filtering, washing and drying a product after complete reaction to obtain the graphene oxide modified starch.
A hydrogel was then prepared, which in this example had the composition: 10 parts of polydimethylsiloxane with the viscosity of 2500Pa & S, 8 parts of sodium hyaluronate, 10 parts of poloxamer, 2 parts of oleyl polyether, 2 parts of small molecular peptide, 8 parts of glycerol, 20 parts of graphene oxide modified starch, 2 parts of a wrinkle removing component, 2 parts of a water supplementing component and 36 parts of water.
And finally, preparing the eye patch, namely forming a carbamate layer on the surface of the substrate backing layer, and then forming the hydrogel layer on the surface of the carbamate layer to obtain the eye patch consisting of the substrate backing layer, the binding layer and the hydrogel layer.
In addition, in order to clarify the specific action and effect of each component in the present invention, the following comparative examples were set for comparison.
Comparative example 1
With reference to example 1, the step of preparing the graphene oxide modified water-soluble film-forming polymer is omitted, and the graphene oxide modified hydroxyethyl cellulose is directly replaced by hydroxyethyl cellulose, so that the hydrogel and the eye patch are prepared accordingly.
Comparative example 2
With reference to example 2, the graphene oxide modified starch component was omitted, and the hydrogel and the eye patch were prepared accordingly.
Comparative example 3
With reference to example 1, a hydrogel and an eye patch were prepared by replacing a polydimethylsiloxane having a viscosity of about 2000Pa · S therein with a polydimethylsiloxane having a viscosity of about 10000Pa · S.
The eye patches obtained in examples 1-2 and comparative examples 1-3 were compared in terms of performance and effect, and the results are shown in the following table. To ensure objectivity of the test structure, women aged between 27 and 32 years were randomly selected to use the above 5 patches of the present invention for 30 days, and effect summary and comparison were performed. Wherein, the A-effect is very obvious, the B-effect is obvious, the C-effect is general, and the D-effect is not.
| Example 1 | Example 2 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Flatness of application | Leveling | Leveling | Leveling | Leveling | Local thickness unevenness |
| Sensory experience with application | Comfort of the wearer | Comfort of the wearer | Comfort of the wearer | Comfort of the wearer | Slight foreign body sensation |
| Water replenishing effect | A | A | B | C | B |
| Whitening effect | A | - | B | C | - |
| De-graining effect | - | A | - | - | B |
In the invention, the polysiloxane elastomer with the viscosity of 500-8000Pa & S and the graphene oxide modified water-soluble film-forming polymer are simultaneously used in the hydrogel for the eye patch, so that comfortable sensory experience of the eye patch can be obtained, and the eye patch is ensured to have excellent effects of moisturizing, whitening, removing wrinkles and the like.
Claims (8)
1. An eye patch comprising a base backing layer, a binding layer, a hydrogel layer, wherein the hydrogel layer comprises the following constituents: 8-12 parts of polysiloxane elastomer, 8-10 parts of sodium hyaluronate, 5-10 parts of poloxamer, 1-3 parts of auxiliary gel-sol agent, 1-2 parts of small molecular peptide, 5-8 parts of glycerol, 20-25 parts of graphene oxide modified water-soluble film-forming polymer, 2-4 parts of skin active ingredient and 30-40 parts of water.
2. The eye patch according to claim 1, wherein the graphene oxide modified water-soluble film-forming polymer is selected from one or more of graphene oxide modified polyethylene oxide polymer, graphene oxide modified polyvinyl alcohol copolymer, graphene oxide modified methyl cellulose, graphene oxide modified carboxymethyl cellulose, graphene oxide modified hydroxyethyl cellulose, graphene oxide modified hydroxypropyl methyl cellulose, and graphene oxide modified starch.
3. The eye patch according to claim 1 or 2, wherein the graphene oxide modified water-soluble film-forming polymer is prepared by a method comprising:
(1) preparing a graphene oxide nanosheet dispersion liquid: dispersing graphene oxide nanosheets in deionized water with the concentration of 3-5g/L, and sequentially carrying out mechanical stirring and ultrasonic shearing to obtain a uniform dispersion liquid;
(2) preparing a water-soluble film-forming polymer aqueous solution, dissolving a water-soluble film-forming polymer to be modified in deionized water at a concentration of 50-80g/L, and mechanically stirring until the water-soluble film-forming polymer is completely dissolved;
(3) graphene oxide catalytic liquid: adding 1-2g of a catalyst into 1L of the graphene oxide nanosheet dispersion liquid in the step (1) to activate carboxyl groups on the surface of the graphene oxide, wherein the catalyst is at least one of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine and N-hydroxysuccinimide;
(4) and (3) mixing the water-soluble film-forming polymer aqueous solution obtained in the step (2) with the graphene oxide catalytic solution obtained in the step (3) according to the volume ratio of 1 (3-5), uniformly stirring, reacting at 40-50 ℃ for 3-4h, and dialyzing, filtering, washing and drying the product after complete reaction to obtain the graphene oxide modified water-soluble film-forming polymer.
4. The eye patch as claimed in claim 3, wherein the rotation speed of the mechanical stirring is 300-500r/min, and the stirring time is 20-30 min; the ultrasonic shearing time is 60-120min, and the ultrasonic frequency is 30-40 KHz.
5. The eye patch according to claim 2, wherein the silicone elastomer has a viscosity of preferably about 500-.
6. The eye mask of claim 2, wherein the binding layer is selected from one or more of ethyl vinyl acetate, acrylate, methacrylate, urethane, polyisobutylene, polystyrene-isoprene copolymer, polystyrene-butadiene copolymer, polybutadiene.
7. The eye mask of claim 2, wherein the auxiliary gel-sol agent is selected from one or more of laureth, oleyl polyether, fatty alcohol polyether, glyceryl stearate, and glyceryl oleate.
8. The eye patch according to claim 2, wherein the skin active ingredient comprises one or more of a spot removing ingredient, a wrinkle removing ingredient, a whitening ingredient, a moisturizing ingredient, and a moisturizing ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202011067470.1A CN111956526A (en) | 2020-10-06 | 2020-10-06 | Eye patch and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011067470.1A CN111956526A (en) | 2020-10-06 | 2020-10-06 | Eye patch and preparation method thereof |
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Application publication date: 20201120 |