CN111903703A

CN111903703A - Active compound composition

Info

Publication number: CN111903703A
Application number: CN201910381838.2A
Authority: CN
Inventors: 罗昌炎; 詹姆斯·T·布里斯托
Original assignee: Jiangsu Rotam Chemical Co Ltd
Current assignee: Jiangsu Rotam Chemical Co Ltd
Priority date: 2019-05-08
Filing date: 2019-05-08
Publication date: 2020-11-10

Abstract

The invention relates to an active compound composition which contains (A) clothianidin and (B) pyraclostrobin. The invention also relates to the use of the active compound compositions for the prevention or control of phytopathogenic fungi and/or harmful organisms; in particular for the treatment of seed to protect the seed from fungal and/or pest attack; also relates to a method for protecting seeds and/or shoots and foliage of plants grown from seeds from attack by phytopathogenic fungi and/or pests.

Description

Active compound composition

Technical Field

The present invention relates to an active compound composition; the invention relates in particular to an active compound combination which is simultaneously effective for controlling phytopathogenic fungi and/or harmful organisms. Also relates to the use of the active compound composition for treating seeds. The invention also relates to a method for improving the health of plants and for protecting seeds from attack by phytopathogenic fungi and/or harmful organisms.

Background

In situations where fungi and/or pests are susceptible to mixing or have developed resistance or risk developing resistance to currently known products, there is a need to find a more effective method of control or prevention.

Seeds and seedlings are easily damaged and infected by various underground and overground pests and pathogenic bacteria, and are the weakest link in the growth process of crops; the phenomena of diseased seedlings and dead seedlings caused by eating of seeds and seedlings by pests or infection of pathogenic bacteria can reduce the effective number of plants of crops in unit area, thereby causing large-area yield reduction and quality reduction of the crops.

The protection of seeds and germinating plants from attack by phytopathogenic fungi and pests by treating the seeds with seed treatment agents has long been known and is a constantly improving study. However, treating seeds also entails a series of problems that cannot always be solved in a satisfactory manner. Therefore, there is a need to develop methods for protecting seeds and germinating plants which avoid the additional application of crop protection products after planting or after emergence of the plants. In addition, it is desirable to optimize the amount of active compound used so that optimum protection is provided to the seed and germinating plant against attack by phytopathogenic fungi and harmful organisms without the active compound used being harmful to the plant itself.

It would be desirable to provide an active compound composition which, when fungi and/or pests are susceptible to mixing, provides improved, e.g. biological, properties such as synergistic properties, especially for the control of phytopathogenic fungi and/or pests in useful plants grown from the treated plant propagation material.

Disclosure of Invention

The invention aims to provide an active compound composition, which contains clothianidin and pyraclostrobin; the active compound combinations are simultaneously effective for controlling phytopathogenic fungi and/or pests.

The invention provides an active compound composition which contains active compounds (A) clothianidin and (B) pyraclostrobin.

The active compound combinations according to the invention have a synergistic action. This effect reduces the incidence of disease by reducing pest infestation and reducing trauma. The active compound combinations according to the invention greatly increase the effectiveness of the control of phytopathogenic fungi and/or pests.

The active compound composition of the invention has the weight ratio of the active compounds in a ratio to obtain the synergistic 1-effect, wherein the weight ratio of the active compounds (A) to (B) is 5:1-50: 1; more preferably from 10:1 to 40: 1; more preferably from 10:1 to 35: 1; more preferably from 10:1 to 30: 1; more preferably from 15:1 to 30: 1.

The active compound composition of the present invention comprises the compounds (A) and (B) in a weight ratio of 5:1,6:1,7:1,8:1,9:1,10:1,11:1,12:1,13:1,14:1,15:1,16:1,17:1,18:1,19:1,20:1,21:1,22:1,23:1,24:1,25:1,26:1,27:1,28:1,29:1,30:1,31:1,32:1,33:1,34:1,35:1,36:1,37:1,38:1,39:1,40:1,41:1,42:1,43:1,44:1,45:1,46:1,47:1,48:1,49:1,50: 1.

The active compound compositions may optionally also contain one or more agriculturally acceptable solid or liquid carriers and/or one or more agriculturally acceptable surfactants.

The active compound composition, which may be in liquid or solid form; preferably in liquid form.

The active compound composition is in the dosage forms of seed treatment slurry wettable powder, seed treatment solution, seed treatment emulsion, seed treatment suspending agent, water dispersible granule, microcapsule suspending agent, oil-based suspending agent, water suspending agent, microcapsule suspension-suspending agent and missible oil.

A further object of the present invention provides the use of the active compound compositions for the treatment of plant propagation material and plant organs which grow subsequently; in particular to the use of said active compound compositions for treating seeds to protect the seeds and germinating plants from attack by phytopathogenic fungi and/or harmful organisms.

The use of the active compound combinations according to the invention for preventing or controlling phytopathogenic fungi and/or harmful organisms.

The use of the active compound compositions described for protecting plants, plant propagation material and plant organs which grow out later. The plant propagation material is a seedling, rhizome, nursery seedling, cutting or seed.

The use of the active compound compositions described for treating plants to protect them from attack by phytopathogenic fungi and/or pests.

The use of said active compound compositions for treating the soil in which plants are growing for protecting plants from fungal and/or pest attack in the soil.

The use of the active compound compositions according to the invention for treating seeds to protect the seeds from fungal and/or pest attack.

It is a further object of the present invention to provide a method for preventing or controlling phytopathogenic fungi and/or pests; in particular to a method for improving the health of plants and protecting seeds from attack by phytopathogenic fungi and/or pests.

The present invention also provides a method for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms, which comprises acting the active compound compositions according to the invention on plants, plant propagation material and subsequently emerging plant organs, cultivation media, materials or spaces.

The present invention also provides a method for the prophylaxis or control of phytopathogenic fungi and/or pests, which comprises applying the active compound compositions according to the invention to plants, to plant propagation material and to the plant organs which grow at a later time, to the soil in which the plants are growing or are to be grown.

The present invention provides a method for the prevention or control of phytopathogenic fungi and/or harmful organisms, which comprises applying the active compound composition according to the invention to the foliage of plants.

The present invention provides a method for the prevention or control of phytopathogenic fungi and/or harmful organisms, which comprises applying the active compound compositions according to the invention to plant propagation material and to the plant organs which grow at a later time.

The present invention provides a method for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms, which comprises applying the active compound compositions according to the invention to the soil in which plants are growing or are to be grown.

The present invention provides a method for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms, which comprises applying the active compound compositions according to the invention to seeds.

The present invention provides a method for the prophylaxis or control of phytopathogenic fungi and/or pests, which comprises acting the active compound composition on plants, plant propagation material and subsequently emerging plant organs, cultivation media, materials or spaces before or after infestation of the plants by phytopathogenic fungi and/or pests.

The present invention provides a method for preventing or controlling phytopathogenic fungi and/or pests, which comprises applying the active compound composition to seed before or after infestation of the plants by phytopathogenic fungi and/or pests.

The present invention provides a method for curatively or preventively controlling the phytopathogenic fungi and/or harmful organisms which comprises applying the crop protection agents of the invention to plants, to plant propagation material and to plant organs, to cultivation media, to materials or to spaces subsequently grown, in an agronomically effective and substantially non-phytotoxic application rate, by seed treatment, foliar application, stem application, drenching, instillation, pouring, spraying, misting, dusting, spreading or smoking.

The term "plant propagation material" is understood to mean all plant parts which are capable of propagating, such as seeds and germinating plants, which can be used for propagating plants, and also plant material, such as cuttings or tubers (e.g. potatoes). Thus, plant parts as used herein include plant propagation material. Mention may be made, for example, of seeds, roots, fruits, tubers, bulbs, rhizomes and plant parts. Germinated plants and useful plants to be suppressed post-emergence or post-emergence from the soil may also be mentioned. The young plants can be protected prior to transplantation by a total or partial treatment by dipping.

The invention also provides a method for protecting seeds, comprising contacting the seeds before sowing and/or after pregermination with an active compound composition according to the invention.

The present invention therefore also relates inter alia to a method for treating seeds with the active compound compositions according to the invention in order to protect the seeds and the germinating plants from attack by phytopathogenic fungi and/or harmful organisms.

The invention also provides a method for protecting seeds and/or shoots and leaves of plants grown from seeds from attack by phytopathogenic fungi and/or pests, which comprises treating the unsown seeds with an active compound composition according to the invention.

Furthermore, the present invention relates to seeds treated with the active compound compositions according to the invention for protection against attack by phytopathogenic fungi and/or pests.

The active compound composition contains active compounds (A) clothianidin and (B) pyraclostrobin, and has a synergistic effect. This effect reduces the incidence of disease by reducing pest infestation and reducing trauma. The active compound combinations according to the invention greatly increase the effectiveness of the control of phytopathogenic fungi and/or pests.

Detailed Description

Most plant damage caused by phytopathogenic fungi and/or pests occurs as early as during storage of the seeds, after sowing the seeds into the soil, and during and shortly after germination of the plants. The roots and shoots of growing plants are particularly sensitive and even minor damage can lead to death of the whole plant. Therefore, the protection of seeds and germinating plants by treating the seeds with suitable seed treatment agents is of particular importance.

At present, the control of phytopathogenic fungi and harmful organisms damaging germinating plants is carried out mainly by treating the soil and the aerial parts of the plants with crop protection products. Due to the possible influence of crop protection products on the environment and on human and animal health, efforts are made to reduce the amount of active compound applied.

Protection of seeds and germinating plants from attack by phytopathogenic fungi and/or harmful organisms by treating the seeds of the plants with crop protection products is another effective method. However, the treatment of seeds often entails a series of problems that are not always satisfactorily solved. For example, some agrochemicals useful for controlling pests and phytopathogenic fungi may also be toxic to seeds and to plants that germinate from seeds. This phytotoxic activity limits the amount of these pesticide chemicals that can be safely used on seeds.

There is a need to provide an active compound composition which, when fungi and/or pests are susceptible to mixing, provides improved, e.g. biological, properties such as synergistic properties, especially for the control of phytopathogenic fungi and/or pests in useful plants grown from the treated plant propagation material.

It has been found that the application of the active compounds (a) and (B) in combination or separately provides a more effective control of phytopathogenic fungi and/or pests than the individual compounds alone; the unexpected synergistic effect is obtained.

Synergistic action means that the application rates of (A) and (B) can be reduced while maintaining the same good action; the compositions achieve a high degree of control of phytopathogenic fungi and/or pests, even in low application rates, in which the individual compounds have become completely ineffective. On the one hand, this leads to a broadening of the spectrum of phytopathogenic fungi and/or pest control which can be controlled; on the other hand, the safety of the plants, plant propagation material and plant organs which grow subsequently is increased.

Accordingly, the present invention provides an active compound composition comprising (a) clothianidin and (B) pyraclostrobin.

The active compound composition according to the invention has a weight ratio of active compounds present in such a proportion that a synergistic effect is obtained, wherein the weight ratio of active compounds (A) to (B) is from 5:1 to 50: 1; more preferably from 10:1 to 40: 1; more preferably from 10:1 to 35: 1; more preferably from 10:1 to 30: 1; more preferably from 15:1 to 30: 1.

The term "composition" in the present invention denotes various combinations of the compounds (a) and (B), for example combinations in the form of: a single "pre-mix" form; forms of combined spray mixtures consisting of individual preparations of a single active compound, such as "tank mix"; and combinations where the individual active ingredients are administered sequentially, i.e. one after the other in a reasonably short time, e.g. hours or days.

According to the present invention, the term "carrier" refers to a natural or synthetic organic or inorganic compound which can be combined or associated with an active compound in order to make it easier to apply to a subject (e.g. a plant, crop or grass). Thus, the carrier is preferably inert, at least should be agriculturally acceptable; the carrier may be a solid carrier or a liquid carrier.

Suitable solid carriers are: examples of the inorganic mineral powder include inorganic mineral powders such as powdery plant materials (for example, particles of soybean powder, starch, cereal flour, wood flour, bark powder, saw dust, walnut shell flour, bran, cellulose powder, coconut shell, corn cob and tobacco stalk, and residues after extraction of plant essence), clays (for example, kaolin, bentonite, acidic china clay, etc.), talc powders, silicas (for example, diatomaceous earth, silica sand, mica, hydrous silicic acid, calcium silicate), activated carbon, natural minerals (pumice, attapulgite, zeolite, etc.), calcined diatomaceous earth, sand, plastic media (for example, polyethylene, polypropylene, polyvinylidene chloride, etc.), potassium chloride, calcium carbonate, calcium phosphate, etc., chemical fertilizers such as ammonium sulfate, ammonium phosphate, urea, ammonium chloride, etc., and earth fertilizers, and these substances may be used alone or in combination of 2 or more.

Suitable liquid carriers can be selected from, for example, water, methanol, ethanol, isopropanol, butanol, ethylene glycol, acetone, methyl ethyl ketone, diisobutyl ketone, cyclohexanone, diethyl ether, dioxane, tetrahydrofuran, and the like, kerosene, mineral oil, benzene, toluene, xylene, solvent oil, alkyl naphthalene, lactate ester, carbonate ester, fatty acid ester, N-methylpyrrolidone, dimethyl sulfoxide, mineral and vegetable oils, animal oil, and the like.

Suitable surfactants are emulsifiers, dispersants or wetting agents of an ionic or nonionic nature, or mixtures of these surfactants.

The emulsifier can be selected from: sodium lauryl sulfate, sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, nonylphenol polyoxyethylene ether phosphate ester amine salt, castor oil polyoxyethylene ether phosphate ester amine salt, phenylphenol polyoxyethylene ether phosphate ester, styrene polyoxyethylene ether ammonium sulfate salt, alkyldiphenyl ether disulfonate magnesium salt, tristyrenol polyoxyethylene ether phosphate ester amine salt, polyoxyethylene fatty amide, alkylpyridinium salt, alkylisoquinolinium salt, dialkylmorpholinium salt, oleamide sulfonate, diisopropylnaphthalene sulfonate, lignosulfonate, naphthalene sulfonate formaldehyde condensate, benzyl dimethylphenol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene block polymer, polyoxyethylene ether, polyoxyethylene ether block polymer, polyoxyethylene ether block polymer, polyoxyethylene ether, polyoxyethylene ether block polymer, polyoxyethylene, One or more of alkylphenol formaldehyde resin polyoxyethylene ether, polyoxyethylene sorbitol fatty acid ester, sorbitan monostearate polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, polyoxypropylene glycol monofatty acid ester and the like.

The dispersing agent can be selected from: one or more of lignosulfonate, sodium p-hydroxyphenyl lignosulfonate, fatty alcohol-polyoxyethylene ether sulfate, alkylnaphthalenesulfonate, naphthalenesulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether formaldehyde condensate, dodecyltrimethylammonium salt, alkyldimethylbenzylammonium salt, polyoxyethylene lauryl ether phosphate, styrene-maleic acid salt copolymer, p-methoxy fatty acid amido benzenesulfonic acid, p-methoxy fatty acid amido benzenesulfonate, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether, glycerin fatty acid polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene lanolin alcohol, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glyceryl monofatty acid ester, alkylolamide, polyoxyethylene alkylamine, and the like.

The wetting agent can be selected from: one or more of sodium lauryl sulfate, calcium dodecylbenzenesulfonate, sodium isooctyl succinate, sodium oleoyl methyltaurate, sodium polyoxyethylene lauryl ether carboxylate, sodium lauroyl sarcosinate, sodium N-lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkylaryl ether phosphate, trisiloxane polyoxyethylene ether, tristyrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene polyether formaldehyde condensate, alkylphenol polyoxyethylene ether phosphate, polyoxyethylene fatty acid ester, higher fatty acid glyceride, sorbitan fatty acid ester, and the like.

The active compound compositions according to the invention may also comprise additional further components, such as disintegrants, thickeners, antifoams, antifreezes, stabilizers, preservatives, pH regulators and the like.

The disintegrating agent can be selected from: sodium carboxymethyl starch, urea, sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate, magnesium chloride, sodium chloride, bentonite, etc.

The thickening agent can be selected from: one or more of acacia, xanthan gum, gelatin, polyvinyl alcohol, polyvinyl acetate, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose and the like.

The defoaming agent can be selected from: butyl phosphate, isobutyl phosphate, n-octanol, silicone, and the like.

The antifreezing agent can be selected from: one or more of ethylene glycol, propylene glycol, glycerol, etc.

The stabilizing agent can be selected from: triphenyl phosphite, N-soybean oil-based trimethylene diamine, dialkyl succinate sulfonate, epichlorohydrin, butyl glycidyl ether, and the like.

The preservative can be selected from: benzoic acid, sodium benzoate, and the like.

The pH regulator can be selected from: hydrochloric acid, sodium hexametaphosphate, sodium citrate, sodium bicarbonate, sodium hydroxide, potassium hydroxide, triethanolamine, etc.

The active compound compositions of the present invention may be provided in solid or liquid form, and may be provided in the form of emulsions, dispersions, solutions or granules.

In general, tank-mixes for foliar or soil application contain 0.1% to 20%, in particular 0.1% to 15%, of active ingredient, and 99.9% to 80%, in particular 99.9% to 85%, of solid or liquid fillers and/or surfactants, where the fillers and/or surfactants may be based on the tank-mix, in amounts of 0% to 20%, in particular 0.1% to 15%, of surfactants.

Typically, the premix for foliar application comprises from 0.1% to 99.9%, especially from 1% to 95%, of the active ingredient, and from 99.9% to 0.1%, especially from 99% to 5%, of a solid or liquid filler and/or surfactant, wherein the filler and/or surfactant may be based on the premix, in an amount of from 0% to 50%, especially from 0.5% to 40%, of the surfactant.

Typically the tank mix for seed treatment applications comprises from 0.25% to 80%, especially from 1% to 75%, of the active ingredient, and from 99.75% to 20%, especially from 99% to 25%, of a solid or liquid filler and/or surfactant, wherein the filler and/or surfactant may be based on the tank mix, in an amount of from 0% to 40%, especially from 0.5% to 30%, of the surfactant.

Typically, the premix for seed treatment application comprises 0.5% to 99.9%, in particular 1% to 95%, of the active ingredient, and 99.5% to 0.1%, in particular 99% to 5%, of a solid or liquid filler and/or surfactant, wherein the filler and/or surfactant may be based on the premix and comprise 0% to 50%, in particular 0.5% to 40%, of the surfactant.

The active compound compositions according to the invention can be prepared by mixing the active compounds in a known manner with one or more agriculturally acceptable solid or liquid carriers and/or one or more agriculturally acceptable surfactants.

The active compound compositions according to the invention can be used in any customary form. Examples of foliar formulations of the premix composition are:

GR granules

WP wettable powder

WG water dispersible granule

SG soluble granule

SL soluble agent

EC emulsifiable concentrate

EW emulsion and aqueous emulsion

ME microemulsion

SC suspension agent

CS microcapsule suspension

OD oil-based suspension concentrate

SE suspension emulsion

Meanwhile, examples of the dosage form for seed treatment of the premix composition are:

WS wettable powder of seed treatment slurry

LS seed treatment solution

ES emulsion for seed treatment

FS seed treatment suspending agent

WG (water dispersible granule)

CS is microcapsule suspending agent.

Examples of suitable dosage forms for tank-mix compositions are solutions, dilute emulsions, suspensions or mixtures and powders thereof.

The preferred formulation of the active compound composition according to the invention is aerosol, capsule suspension, cold fogging concentrate, hot fogging concentrate, capsule granules, fine granules, ready-to-use solution, sprayable powder, emulsifiable concentrate, oil-in-water emulsion, water-in-oil emulsion, macro granules, micro granules, oil dispersible powder, oil miscible flowable concentrate, oil miscible liquid, foam, paste, suspension concentrate, soluble concentrate, suspension, seed coating, wettable powder, water dispersible granules, soluble powder, microcapsule suspension, coated granules, extruded granules, emulsifiable concentrate, microemulsion, aqueous emulsion, effervescent tablets, ultra low volume liquid, suspoemulsion, ultra low volume cold fogging formulation, ultra low volume hot fogging formulation, double package (twinpack), dry powder, seed treatment emulsion, seed treatment suspension, dry powder, oil-in-water emulsion, effervescent tablet, ultra low volume liquid, suspension concentrate, oil-in-water emulsion, water dispersible granule, oil dispersible powder, seed treatment liquid, seed treatment dispersible powder, seed treatment microcapsule suspending agent, suspoemulsion, emulsion granule, ultra-low volume suspending agent, ultra-low volume liquid, and dispersible concentrate.

The active compound compositions of the present invention include not only compositions which can be applied to the subject to be treated immediately by means of a suitable device, such as a spraying or dusting device, but also concentrated, commercially available compositions which are intended to be diluted prior to application to the subject.

The invention also provides the use of the active compound combinations for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms.

The use of the active compound compositions according to the invention for the treatment of plant propagation material and plant organs which grow out later; in particular to the use of said active compound compositions for treating seeds to protect the seeds and germinating plants from attack by phytopathogenic fungi and/or harmful organisms.

The active compound compositions according to the invention can be used for the treatment of any kind of plant seed, preferably seed of agronomic plants. The term "agronomic plant" refers to a plant cultivated by any person or harvested part or product thereof for human use. The agronomic plant may be a gymnosperm, a dicotyledon, or a monocot.

Examples of agronomic plants useful in the present invention include, but are not limited to: cereals (wheat, barley, rye, oats, rice, sorghum, related crops, etc.), sugar beets, stone fruits, apples, pears, plums, peaches, apricots, cherries, strawberries, blackberries, tomatoes, peppers, etc.), beans (beans, lentils, peas, soybeans), oil plants (oilseed rape, canola, mustard (canola), mustard, poppy, olives, sunflowers, coconuts, castor beans, cocoa beans, peanuts, soybeans, corn, etc.), cucurbits (squash, cucumbers, melons, etc.), citrus plants (citrus, lemon, grapefruit, tangerine, cabbage, chinese cabbage, radish, carrot, onion, potato, etc.), camphor trees (avocado, cinnamon, camphor, etc.), corn, tobacco, nuts, coffee, sugar cane, tea, grape trees, hops, and bananas.

Suitable seeds are seeds of cereals, root crops, oil crops, vegetables, spices, ornamentals. For example, seeds of the following plants: durum and other wheat, barley, oats, rye, corn (fodder and sweet/sweet and field corn), soybean, oil crops, crucifers, cotton, sunflower, banana, rice, oilseed rape, kohlrabi, sugar beet, fodder beet, eggplant, potato, grass, turf, pasture, tomato, tuber onion, squash, cabbage, pepper, cucumber, melon, bean, pea, garlic, onion, carrot, tuber plants (such as potatoes), sugar cane, tobacco, grape, petunia, geranium, pansy and impatiens.

The active compound compositions according to the invention are preferably used for the treatment of seeds for rice, wheat, barley, maize, cotton, soya, peanut; in particular wheat, corn, cotton, soybean, rice, peanut; more particularly for treating seeds of rice, rape, cotton, wheat, barley, soybean, maize, peanut.

The use of the active compound compositions according to the invention for the treatment of seeds to protect the seeds and germinating plants against phytopathogenic fungi. The active compound compositions according to the invention can be used for the treatment of seeds to protect the seeds and germinating plants against a wide variety of phytopathogenic fungi. For example: is selected from the group consisting of Ascomycetes (Ascomycetes), Basidiomycetes (Basidiomycetes), Phycomycetes (Phycomycetes) and Deuteromycetes (Deuteromycetes).

Oomycetes, including Phytophthora (Phytophthora), such as Phytophthora infestans (Phytophthora sojae), Phytophthora sojae (Phytophthora sojae. gaspierma), Phytophthora citrus (Phytophthora parasitica), Phytophthora cinnamomi (Phytophthora cinnamomi), and Phytophthora cucurbitae (Phytophthora capsici); diseases of Pythium species (Pythium), such as Pythium turfgrasum fusarium (Pythium aphanidermatum); and diseases of the Peronosporaceae family (Peronosporae) such as Plasmopara viticola (Plasmoparaviticola); peronospora species (Peronospora) (including Peronospora tabacum (peronosporaabacina) and Peronospora parasitica (Peronospora paralica)); pseudoperonospora (Pseudoperonospora) species of bacteria (including Pseudoperonospora cubensis (Pseudoperonospora cubensis) and Bremia (Bremia lactucae), Pythium (Pythium) species such as Pythium aphanidermatum (Pythium aphanidermatum), and Plasmopara (Plasmopara).

Ascomycetes, including Alternaria (Alternaria) diseases such as early blight of tomato (Alternaria) and black spot of cabbage (Alternaria); globulus (Guignardia) diseases such as botrytis cinerea (Guignardiabidwelli); scabies (Venturia) diseases such as apple scab (Venturia inaequalis); septoria (Septoria) diseases such as glume blight (Septoria nodorum) and leaf blight (Septoria); erysiphe species (Erysiphe) such as Erysiphe graminis (Erysiphe graminis) and Ustilaginoidea virens (Erysiphe polygonini), Stachybotrys graminis (Uncinula necaurantiaca), Cucumis sativus erysipelas (Sphaerothecaulogena) and Malaria pumila (Podosphaeraleucotricha); species of pseudocercospora herpotrichoides; diseases of Botrytis species such as Botrytis cinerea (Botrytiscinerea), Monilinia persicae (Moniliniafructicola) diseases; diseases of species of the genus Sclerotinia (sclerotina) such as Sclerotinia sclerotiorum (sclerotina sclerotiorum); pyricularia species (Pyricularia oryzae Ecav.) such as Magnaporthegrisea; helminthosporium species diseases such as the species alternaria turcicola (Helminthosporium tritici), reticulata (pyrenophores); anthrax (Colletotrichum) species such as Colletotrichum kamuranus (Colletotrichumgraminicola) and Colletotrichum citrulli (Colletotrichum biculare)); gaeumannomyces graminis such as gaeumannomyces graminis (gaeumannomyces graminis); genus aphanotheca (Podosphaera); streptozoctonia (Monilinia); devil's claw (Uncinula); mycosphaerella (Mycosphaerella).

Basidiomycetes, including rust diseases caused by rusts (Puccinia genus) (e.g., Pucciniarecondita (Pucciniarecondita), Pucciniastriiformis (Pucciniastriiformis), Puccinia (Pucciniahordei), Puccinia (Pucciniagraminis), and Pucciniarachidia (Pucciniaarachidis)), coffee rusts (Hemilavastarix), Camellia rusts (Hemiliia), soybean rusts (Phakopsorapaphyrizi); smut (Llstilaginalcs).

Deuteromycetes, including Rhizoctonia species (such as Rhizoctonia solani (Rhizoctonia) and Rhizoctonia rubescens (Rhizoctonia oryzae)), Fusarium (Fusarium) diseases, such as Fusarium graminearum (Fusarium graminearum), Fusarium candidum (Fusarium moniliforme), Fusarium oxysporum (Fusarium oxysporum), Fusarium moniliforme (Fusarium proliferatum), Fusarium solani (Fusarium solani), Verticillium dahliae (Verticillium dahliae), Rhizoctonia sclerotiorum (Sclerotinula rolfsii), Physalospora reticulata (Rychiaspora), Rhizoctonia nigra (Cercosporium), Pyrophora (Pyrococcus), Pyrococcus cercosporium (Pyrococcus), and Pyrococcus (Fusarium), Fusarium solani (Pyrococcus) and Fusarium (Pyrococcus).

The active compound combinations according to the invention are effective in particular against the following phytopathogens: pythium (Pythium), Fusarium (Fusarium), Rhizoctonia (Rhizoctonia), Phytophthora (Phytophthora), Botrytis (Botrytis), Pyricularia (Pyricularia), Helminthosporium (Helminthosporium), Fusarium (Fusarium), Septoria (Septoria), Cercospora (Cercospora), Alternaria (Alternaria), Pyricularia (Pyricularia), Pseudocercospora (Pseudocercospora), Rhizoctonia (Rhizoctonia), camelina (hematuria), Puccinia (Puccinia), usticum (wolfiporia), Fusarium (Phytophthora), Phytophthora (Plasmopara), Phytophthora (Phytophthora), Phytophthora (Pseudoperonospora (Phytophthora), Phytophthora (Phytophthora) and Phytophthora (Phytophthora) are (Phytophthora).

The active compound combinations according to the invention are particularly effective against phytopathogenic fungi on:

diseases of rice: magnaporthegrisea, Cochliobacter oryzae (Cochliobolus miyabenus), Rhizoctonia solani (Rhizoctonia), cellulose-degrading bacteria (Gibberellafujikuroi);

wheat diseases: gramineous powdery mildew (erysiphe graminis), fusarium graminearum (fusarium graminearum), f.avenacum, fusarium culmorum (f.culmorum), snow mold leaf blight (microdochiumnivalate), wheat stripe rust (pucciniae), wheat straw rust (p.graminis), wheat leaf rust (p.recandia), snow mold (micronictiella nivale), wheat flour smut (ustilagoti), wheat reticuloticus (tillus), wheat basal rot (pseudomonas aeruginosa), wheat needle spore (mycosphere graminis), glume nodosum (stanospora nodosa), wheat straw rot (pyelothecium graminis), wheat basal rot (pseudomonas graminearum), wheat straw spore (polyporus graminearum-rei);

barley diseases: gramineous (erysiphe graminis), fusarium graminearum (fusarium graminearum), f.avenaceum, fusarium culmorum (f.culmorum), snow mold leaf blight (microdochiumnivalate), wheat stripe rust (pucciniae), wheat straw rust (p.graminis), barley brown rust (p.hordei), black powdery mildew (ustilanida), barley leaf rot (ryncosporium), barley net blotch (phytophthora infestans), barley spot germ (cochliobolus), barley stripe germ (pyrenophora graminea), sheath blight (rhizoctonia solani);

corn diseases: ustilago zeae (Ustilago maydis), Cochlospora heterosporum (Cochliobolus heterosporus), Cercospora johnsonii (Gloecocosporansghi), Puccinia polycarpa (Puccinia polysora), Botrytis zeae (Cercosporaceae-maydis), Rhizoctonia solani (Rhizoctoniaspalasonii), Pythium zeae (Pythimum fluoride matrix.), Anthragma zeae (corn anthracnose), Fusarium zeae (Fusarium graminearum).

Citrus diseases: aschersonia (Diaporthecii), Cicerospora citrella (Elsinoefawceti), Penicillium digitatum (Penicillium digitatum), Penicillium italicum (P. italicum), Nicotiana tabacum (Phytophthoraparatica), Phytophthora citri (Phytophthoractrophthora);

apple tree diseases: sclerotinia sclerotiorum (monilinia), valproa canker (valproa), aleureria pulmona (podosphaera), alternaria mali (alternaria lobata), alternaria mali (alternaria alternata), alternaria mali (venturia inaequalis), anthracnose (colletotrichum);

pear tree diseases: venturia inaequalis (v. pirina), alternaria alternata (alternaria japonica japan), rust disease (gyrosporangium haratum), phytophthora malorum (phytophthora malorum);

peach tree diseases: brown rot fungus (monilini fructicola), cladosporium cucurbitatum (cladosporium carpopophilum), the endophytic fungus of neem plant (phenopsisp.);

grape diseases: vitiligo (Elsinoeampinelina), Microchacterium circinelloides (Glomellanthus), erysiphe necator (Uninulanecator), phakopsora (Phakopsoraamopelopsis), Mycobacteria vitis (Guignardiabidwellii), Peronospora destructor (Plasmoparaviticola);

persimmon tree diseases: sporophytes of persimmon (Gloeosporiumkaki), persimmon angular leaf spot (Cercosporakaki), coccomycotina of persimmon (mycosphereelawae);

gourd diseases: colletotrichum cucurbitacearum (colletotrichum lagenarium), erysiphe cucumerinum (sphaeraceae), fusarium oxysporum (fusarium oxysporum), peronospora cubensis (pseudoperonospora cubensis), phytophthora parasitica (phytophthora), pythium (pythium sp.);

tomato diseases: early blight of tomato (Alternaria), Phytophthora solani (Cladosporium fulvum), late blight of potato (Phytophthorainfantis);

eggplant diseases: phomopsis (phomopsis vexans), erysiphe cichororaceae (erysiphe cichoracearum);

diseases of cruciferous vegetables: alternaria Raphani (Alternaria japonica), white spot (Cercosporella brassicca), Plasmodiophora (Plasmodiophora brassicca), Peronospora parasitica (Peronosporaparitica);

onion diseases: pucciniaallii (Pucciniaallii), Peronospora destructor (Peronosporasterctors);

soybean diseases: soybean purpurea (cercosporakikuchi), soybean elsinoeglycocinia (elsinoeglycocinia), podocarpus phaseoloides (diaporthe phaseolorum var. sojae), septoria fusca (septoria), soybean griseofulensis (Cercosporasojina), phakopsora pachyrhizi (phakopsoriazuri), phytophthora sojae (phytophthora sojae), rhizoctonia solani (rhizoctoniasolasonii), corynebacterium sp (corynebacterium), corynebacterium (corynebacterium caseoides), sclerotinia (sclerotiorum);

bean diseases: colletotrichumlindelmthaanum;

peanut diseases: coccobacillus (Cercosporaraperonata), ananas arachidicola (Cercosporararachidicola), sclerotium alba (Sclerotiumrolfsii);

pea diseases: pea powdery mildew (Erysiphepisi);

potato diseases: potato late blight (phytophthora infestans), phytophthora infestans (phytophthora infestans), potato powdery scab (spongospora scabbing terrana, f.sp.subterranean);

strawberry diseases: erysiphe (Sphaerothecahumuli), Sphaerotheca circinelloides (Glomeellacingulata);

tea tree diseases: exophiala reticulata (Exobasidium reticulatum), Alternaria chrysosporium (Elsinoeleucospira), Pestalotiopsis sp, Colletotrichum anthracnose (Colletotrichum-sinensis);

tobacco diseases: alternaria alternata (alternaria alternata), erysiphe cichororaceae (erysiphe cichororaceae), colletotrichum nicotianae (colletotrichum tabacum), peronospora tabacum (peronospora tabacum), peronospora tabacum (phytophthora nicotianae);

rape stalk disease: sclerotinia sclerotiorum (sclerotiniobacterium), rhizoctonia solani (rhizoctonia solani);

cotton diseases: rhizoctonia solani (rhizoctonia solani);

beet diseases: cercospora betanae (cercospora betacola), Rhizoctonia solani (thanatephorus), Rhizoctonia solani (aphanomyces cochlioides);

diseases of Rosa: rosa bivalvia (Diplocarponrosae), Rosa filamentosa (Sphaerothecapanannosa), Rosa peronospora (Peronospora parsa);

diseases of plants of the Compositae and Asteraceae: bremia lactuca (Bremia lactuca), Septoria septoria (Septoria sinensis-indica), Horikoshi rust (Pucciniahoriana);

various plant diseases: pythium graminearum wilt (pythium aphanidermatum), pythium debaryanum, pythium graminum (pythium graminicola), pythium teratum (pythium irregorale), pythium ultimum, botrytis cinerea (Botrytiscinerea), sclerotinia sclerotiorum (sclerotinia sclerotiorum);

radish diseases: alternaria brassicae (alternarabrassicicola);

zoysia japonica disease: silver spot pathogen (sclerotinia homococca), rhizoctonia solani (rhizoctonia solani);

banana diseases: myrothecium virescens (mycosphaeraseliaensis), mycosphaerella mussaensis (mycosphaerella sp.);

sunflower diseases: peronospora species (Plasmopara halstedii).

The active compound compositions of the invention are effective in particular against seed diseases or diseases at the early stages of plant growth caused by: ustilago (Ustilago), Aspergillus (Aspergillus), Penicillium (Penicillium), Fusarium (Fusarium), Gibberellaspp (Gibberellaspp), Trichoderma (Tricodermaspp), Rhinochromyces (Thielavissipp), Rhizopus (Rhizopusspp), Mucor (Mucorspp), Coriolus (Corticiumspp), Phoma (Rhomaspp), Rhizoctonia (Rhizoctoniaspp), Diplasmodium (Diplodia), Ustilago (Sphacelotheca), and the like.

Preferably, the active compound combinations according to the invention for the prevention or control of plant diseases comprise: basic stem rot, root rot, damping off, bakanae disease, leaf spot, scab, white silk, anthracnose, northern leaf spot, banded sclerotial blight, false smut, rice blast, leaf spot of flax, rust disease, powdery mildew, net blotch, gibberellic disease, head smut, seed-borne wheel spot, loose smut of wheat, damping-off and gray leaf spot.

Fungi which occur on plants or on plant organs (fruits, flowers, leaves, stems, tubers, roots) of different useful plants can be prevented or destroyed by the active compound combinations according to the invention, whereby plant organs which continue to grow thereafter are not attacked by these fungi. It can also be applied post-harvest or applied as a seed dressing, or used for the treatment of plant propagation material, in particular seeds.

The use of the active compound compositions according to the invention for treating seeds to protect the seeds and germinating plants against attack by pests. Such pests include, for example: lepidoptera, coleopteran, diptera, homoptera, hemiptera, hymenoptera, thysanoptera, and the like.

Lepidopteran pests include, for example: chilospora (chilopodisclosed) (Walker), Tryporyza incertulas (Walker), Cnaphalocrocis medinalis (cnaphalocrocis medinalis), Pieris medinalis (Wallichenbacea), Pieris punctifera (Hellullaundalis), Pieris punctifera (Conethospunctivis), Pieris citrifolia (Papilioxus), Pieris alba (Pieris rapacivora), Plectria recti (parafarica), Pleurospora canicola (Pararugosus), Pieris versicolor (Maliosomala Neustitica), Pieris dispirica (Lymantria dispar), Hyphantria cunea (Hypphaleria punctata), Pleurospora orientalis (Hypoglauca), Spirocha veneta (Spodoptera), Spodoptera nigrostrinia (Spodoptera), Spodopterocarpa punctifera (Spodopterocarpa punctifera), Spodopterocarpus punctifera (Spodopterocarpus punctifera), Spodopterocarpus punctifera (Spodopterocarpus punctifera), Spodopteria frugiperda (Spodopterocarpus punctifera), Spodopteria (Spodopterocarpus punctifera), Spodopteria frugiperda (Spodopteria frugium), Spodopteria frugiperda (Spodoptera), Spodopteria frugiperda (Spodopterocarpa), Spodopteria frugiperda (Spodopterocarpa), Spodopterocarpa punctata (Spodopterocarpa), Spodopteria frugiperda (Spodopteria frugiperda), Spodopter.

Coleopteran pests include, for example: elephants (sinophilius oryzae eine), elephants of corn (s.zeamais), elephants of grain (s.granaria), apes (gibberella), apes (cabbegeleaf beetle), apes (daikonleaf beetle), flea beetle (flambe), grape flea beetle (altiachalyba), striped flea beetle (phyllotratatriola), cucumber flea beetle (epitixcuccumeris), tobacco flea beetle (ehirtiphennis), eggplant beetle (e.fuscula), yellow datura (autolorandica (gemlin), yellow striped flea beetle (phyllotraspp), white grub (holotrichia balica bates), and golden beetle (Elateridae).

Dipteran pests include, for example: rice plant fly (agromozaoryza), barley water fly (hydralligriseola), gerbera camomilla (liriomyzatrifolii), pea leaf fly (chromoniahorticola), tomato leaf fly (liriomyzabryoniae), gray fly (delactatura), green onion fly (delavata) mediterranean fly (ceratitis capitata wiedman), apple fly (rhagoletisponella), cherry fly (r.

Hemipteran pests include, for example: stinkbug (megatiptatticimum), corium elephatis (eurydemasum), stinkbug (eusartorius major), stinkbug (eusarcocylilissis), stinkbug (eusarcocorisparvus), stinkbug (nezaraviridula), stinkbug (platistali), stinkbug (halirphista), stinkbug (clethostachydigitalis), stinkbug (clethostus punctiger), stinkbug (lygus lucentis), stinkbug (leptospiensis), stinkbug (sterrisitis), and stinkbug (gonotylupestium).

Homopteran pests include, for example, the leafhopper (nonphyttixcinceps), the laodelphax striatellus (laodelphaxstratella), the brown planthopper (nilaparvatalens), the sogatella furcifera (sogatella furcifera), the psylla pyricularis (psyllicularia), the diaphorina citri (diaphorinatabaaci), the bemisia tabaci (bemisia), the aphid (homoptera), the aphis malus (erioglaciarius).

Among hymenoptera (hymenoptera), there are Ouioia flaviperida (athaliararosa ruficornis), Argemina rosea (Argepagana), Formica japonicum (Formicajonica), Castanea mollissima (dryocsumuriphilus), and the like.

Thysanoptera pests (Thysanoptera) of the family thrips (Thripidae), such as Frankliniella occidentalis, Frankliniella asiatica, Frankliniella harderi (Scirothripsis), Frankliniella tabaci (Thripsabacavirus), Frankliniella quinquefolia (Frankliniella intonasa), Frankliniella solani (Frankliniella fusca).

The active compound combinations according to the invention are particularly suitable for controlling pests such as cutworm (agrostipsilon), white grub (micromelaucidulella hope), armyworm (mythimnasedata (Walker)), chilo suppressalis (Chilossuppersalis (Walker)), tryporyza incertulas (Trypazaincertulas) (Walker), Cnaphalocrocis medinalis (Cnaphalocrocis medinalis Guenee), rice bud (Ricehellpest), aphid (Homoptera), Sogatella furcifera (Sogatella furcifera), Nilapavatalus (Nilapavatalugens), Plutella xylostella (Plutella xylostella), Spodoptera exigua (Spodoptera), Spodoptera litura (Lignocardia), Spodoptera littora (Ligulata), Spodoptera litura (Spodoptera), Spodoptera litura (Spodoptera litura), Spodoptera litura (Spodoptera frugiperda (Spodoptera), Spodoptera litura (Spodoptera litura), Spodoptera frugiperda (Spodoptera litura), Sphaemaphila (Spodoptera), Spodoptera litura (Spodoptera littora (Spinosa), Spinosa (Spinosa litura), Spinosa (Spinosa), Spinosa littora (Spinosa), Spinosa (Spinosa), Spinos.

Preferably, the pests to which the active compound compositions of the invention are applied for prophylaxis or control include: brown planthopper, thrips, leaf miner, striped rice borer, yellow rice borer, cotton bollworm, asparagus caterpillar, aphid, bemisia tabaci, cabbage caterpillar, striped flea beetle, diamond back moth, prodenia litura, black cutworm, rice leaf roller, whitefly, bean pod borer, armyworm, nematode, wireworm and grub.

The active compound composition is used for treating seeds to protect the seeds and germinating plants from being invaded by harmful organisms such as cutworms, wireworms, grubs, mole crickets, root knot nematodes, thrips, aphids, trematodes, whiteflies, rice planthoppers, longicorn beetles, scale insects, tea lesser leafhoppers, cotton bollworms, asparagus caterpillars, striped rice borers, tryporyza incertulas, black tail leafhoppers, prodenia lituras, diamond back moths and the like.

The present invention also provides a method for protecting seeds from attack by phytopathogenic fungi and/or pests and/or for improving the health of plants, which comprises contacting the seeds before sowing and/or after pregermination with an active compound composition as described herein.

Most of the damage to crop plants caused by phytopathogenic fungi and pests occurs as early as during storage of the seeds and after the seeds have been sown into the soil and during or after germination of the plants. This stage is particularly critical because the roots and shoots of growing plants are particularly sensitive, and even minor damage can lead to death of the entire plant. Therefore, it is of particular interest to treat seeds to protect the seeds and germinating plants by applying suitable seed treatment agents. Also mentioned are germinating plants and useful plants to be suppressed after germination or after emergence from the soil. The young plants can be protected prior to transplantation by a total or partial treatment by dipping.

The present invention therefore also relates to a method for protecting seeds from attack by phytopathogenic fungi and/or pests, in particular soil germs and pests, and of the seedlings' roots and shoots from phytopathogenic fungi and pests, in particular soil and foliar fungi and pests, which comprises contacting the seeds before sowing and/or after pregermination with an active compound composition according to the invention.

The seed treatment composition of the invention is particularly advantageous for treating plant seeds, in particular seeds of rice, rape, cotton, wheat, barley, soybean, maize, peanut.

A method for protecting seeds, which comprises contacting the seeds before sowing and/or after pregermination with a synergistically effective amount of the active compound compositions according to the invention.

A method for protecting seeds and/or shoots and foliage of plants grown from seeds from attack by phytopathogenic fungi and pests which comprises contacting the seeds before sowing and/or after pregermination with a synergistically effective amount of the active compound compositions according to the invention.

The method for protecting seeds according to the invention comprises a method for treating the seeds simultaneously or separately with the active compound (a) and the active compound (B).

The invention also relates to a seed treated with an active compound composition according to the invention.

The active compound compositions according to the invention can be applied to the seed as such or in suitable dosage forms. Preferably, the seeds are treated in a steady state so that the treatment does not cause any damage. The treatment of the seeds can generally be carried out at any time between harvesting and sowing. Care must generally be taken during seed treatment that the amount applied to the seed and/or the amount of other additives is selected so as not to affect the germination of the seed or damage the crop plants. Seed treatment is applied before the plant is sown or before the plant emerges.

As used herein, "improving plant health" refers to improving crop characteristics, including: emergence, crop yield, protein content, more developed root system, tillering increase, plant height increase, leaf enlargement, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less fertilizer needed, less seeds needed, improved water stress tolerance, increased plant vigor, increased plant stand and early germination; or other advantages known to those skilled in the art.

Biological test example

Synergistic effects exist when the effect of the active compound combination exceeds the sum of the effects when the active compounds are administered separately. The expected effect of a particular combination of two active compounds can be calculated using the so-called "Colby formula" (cf. s.r. Colby, "cutting synergy and diagnostic responses of pharmacological compositions", Weeds1967,15,20-22) if

X is the pharmacological effect when using active compound A in mg/ha or mppm concentration;

y is the effect when active compound B is used in ng/ha or nppm concentration, expressed as a percentage of the untreated control;

e is the activity when using active compound A, B in amounts m and ng/ha or concentrations mppm and nppm,

then

E=X+Y-XY/100

If the observed effect of the active compound combination is higher than the expected effect "E", the combination of the two active compounds has a superadditive, i.e. synergistic, effect.

Test example 1 Effect against head smut of corn

The test plot is flat, the soil quality is black calcium soil, the soil is fertile, the soil fertility is basically consistent, and the pH value of the soil is about 7. The experimental ground is divided into a plurality of experimental cells according to experimental design requirements. Area per cell is 30m². 3 replicates.

The active compounds are applied as dry seed dressings. By mixing the active compound alone or in combination with finely ground minerals, a finely powdered composition is obtained which is uniformly distributed over the surface of the seed.

When the seeds are mixed, the medicaments are mixed into slurry according to the designed dosage, then the seeds and the liquid medicine are shaken in a closed glass flask for 3 minutes, after the seeds are evenly coated with the medicine, the seeds are poured out and spread out to be placed in a ventilation position, and the seeds are sowed after being dried. (the ratio of the amount of the syrup to the seeds is 1: 100)

Adopting an artificial inoculation mode, and preparing the fine soil and the head smut fungus spore powder into 0.1 percent of fungus soil according to a ratio of 1000:1 for later use. Corn is sown by a hole sowing method, and 50g of 0.1% fungus soil is covered in each hole after sowing.

After the corn is sowed for one week, the emergence condition of the corn is observed at any time. And (4) when the symptoms are obvious after the ears are full, poor adjustment is carried out, and the occurrence condition of the maize head smut in each cell is observed and recorded.

Drug effect calculation method

TABLE 1

The combination of clothianidin and pyraclostrobin has an unexpected synergistic effect on preventing and treating the maize head smut; and the combination had no adverse effect on corn growth at each of the concentrations tested.

Test example 2 Effect on controlling corn Stem root rot

The corn stalk base rot pathogen is cultured by adopting a liquid shake bacteria mode. The concentration of pathogenic bacteria spores reaches 106/mL, two kinds of pathogenic bacteria (pythium and fusarium) are independently subjected to liquid shaking and then mixed in a ratio of 1: 1; adding 50ml into 600g sterilized corn kernels, incubating in an incubator for 7-10 days, pouring out the corn kernels with mycelium, and drying in the shade; each hole is covered with 20g when the seeds are sowed.

When the corn is sowed, seeds after seed dressing treatment and seeds with bacteria are sowed in the same hole (the weight ratio of the seeds after seed dressing treatment to the seeds with bacteria is 1: 10). After the corn is sowed for one week, the emergence condition of the corn is observed at any time. The occurrence of the corn stalk rot in each cell was observed and recorded after 40 days.

Drug effect calculation method

Table 2:

the combination of clothianidin and pyraclostrobin achieves unexpected synergistic effect on preventing and treating the basal rot of the corn stalk; and the combination had no adverse effect on corn growth at each of the concentrations tested.

Test example 3 determination of control Effect of greenhouse potting-cutworm

Corn variety Yu 335 is selected first. When the seeds are mixed, the medicaments are mixed into slurry according to the designed dosage, then the seeds and the liquid medicine are shaken in a closed glass flask for 3 minutes, after the seeds are evenly coated with the medicine, the seeds are poured out and spread out to be placed in a ventilation position, and the seeds are sowed after being dried.

The test was carried out with the same soil and sand source and without any pesticide treatment. Each treated 60 seeds, 3 replicates, and each replicate 20. All treated pots were placed at 15^oC in a controllable sunlight greenhouse. And observing the growth condition of the crops. After emergence, 15 corns are planted in each pot. And 5-head 4-year old black cutworm larvae are potted in each pot on the 7 th day after emergence. 5 days after inoculation, pots are cleaned, the condition of the cutworms treated is checked, and the damage rate and the larva mortality rate are calculated.

Percent damage rate (%) = (number of strains of little cutworm bitten/total number of strains) × 100%

Dead insect rate (%) = (dead insect number/total insect number) × 100%

Table 3:

the combination of clothianidin and pyraclostrobin achieves unexpected synergistic effect on controlling the soil insects, namely the cutworms; and the combination had no adverse effect on corn growth at each of the concentrations tested.

Test example 4 measurement of control Effect on greenhouse potting-on grubs

The test was carried out with the same soil and sand source and without any pesticide treatment. Each treated 60 seeds, 3 replicates, and each replicate 20. All treated pots were placed at 15^oC in a controllable sunlight greenhouse. And observing the growth condition of the crops. After emergence, 15 corns are planted in each pot. 5 grub larvae are transplanted in each pot on the 7 th day after emergence. 5 days after inoculation, the grubs are cleaned, the grubs are checked for damage, and the damage rate and the larva mortality rate are calculated.

The damage rate (%) = (number of grub-bitten and broken seedlings/total number of the grub) × 100%

Dead insect rate (%) = (dead insect number/total insect number) × 100%

TABLE 4

The combination of clothianidin and pyraclostrobin achieves an unexpected synergistic effect on controlling grubs of soil insects; and the combination had no adverse effect on corn growth at each of the concentrations tested.

Claims

1. An active compound composition, which is characterized by comprising (A) clothianidin and (B) pyraclostrobin.

2. Active compound composition according to claim 1, characterized in that the weight ratio of active compounds (a) and (B) in the active compound composition is from 5:1 to 50: 1; more preferably from 10:1 to 40: 1; more preferably from 10:1 to 35: 1; more preferably from 10:1 to 30: 1; more preferably from 15:1 to 30: 1.

3. The active compound composition according to claim 1, further comprising one or more agriculturally acceptable solid or liquid carriers and/or one or more agriculturally acceptable surfactants.

4. The active compound composition according to claim 1, wherein the dosage form is a wettable powder for seed treatment slurry, a seed treatment solution, an emulsion for seed treatment, a suspension for seed treatment, a water dispersible granule, a microcapsule suspension, an oil-based suspension, an aqueous suspension, a microcapsule suspension-suspension, or an emulsifiable concentrate.

5. Use of the active compound combinations according to claim 1 for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms.

6. Use of the active compound compositions according to claim 1 for treating plant propagation material and subsequently emerging plant organs to protect plants from attack by phytopathogenic fungi and/or pests.

7. Use of the active compound compositions according to claim 1 for treating plants to protect them from attack by phytopathogenic fungi and/or pests.

8. Use of the active compound composition according to claim 1 for treating the soil in which plants are growing to protect the plants from fungal and/or pest attack in the soil.

9. Use of the active compound composition according to claim 1 for treating seeds for protecting the seeds from fungal and/or pest attack.

10. A method for the prophylaxis or control of phytopathogenic fungi and/or harmful organisms, which comprises applying an active compound composition according to claim 1 to plants, to plant propagation material and to the plant organs which grow at a later time, to the soil in which the plants grow or are to be grown.

11. A method for the prophylaxis or control of phytopathogenic fungi and/or pests, which comprises applying the active compound compositions according to claim 1 to plants, to plant propagation material and to the subsequently emerging plant organs, to the soil on which the plants are growing or are to be grown, before or after infestation of the plants by the phytopathogenic fungi and/or pests.

12. A method for protecting seeds and/or shoots and foliage of plants grown from seeds from attack by phytopathogenic fungi and/or pests, which comprises treating the unsown seeds with an active compound composition according to claim 1.

13. The method according to claim 12, comprising treating the unsown seed simultaneously or separately with active compound (a), active compound (B).