CN111728217A - 一种玛咖纳豆制品复合制剂及其制备方法 - Google Patents
一种玛咖纳豆制品复合制剂及其制备方法 Download PDFInfo
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Abstract
本发明属于保健品食品领域，具体涉及一种玛咖纳豆激酶复合制剂及其制备方法，由以下组分构成：玛咖提取物、纳豆制品、人参、寡聚糖、水溶性膳食纤维、沙棘果、黑枸杞提取物、促生长激素；玛咖与纳豆激酶相结合是本发明首次提出，可以有效增强男性精力，增加受孕率。针对纳豆激酶在胃液中容易失去活性的问题，本发明首次将其做成了肠溶性微囊，在经过胃时不会被消化。在到达人体小肠时可以充分的释放出来。制成的微囊既可以掩盖纳豆激酶的特殊味道，也可以增加吸收效果。
Description
技术领域
本发明属于保健品食品领域，具体涉及一种玛咖纳豆制品复合制剂及其制备方法。
背景技术
玛咖(MACA)，一种生长在南美洲秘鲁安地斯山区海拔四千米以上的高原上的植物，属十字花科。原产于秘鲁中部基宁及帕斯科附近4000米以上的安第斯山区。MACA富含高单位营养素，对人体有滋补强身的功用，食用过的人会有体力充沛、精神旺盛不会疲劳的感觉；MACA并且能促进新陈代谢、抵抗压力并提升人类及动物的性能力，生育力及乳汁分泌，并能消除更年期障碍、减缓老化、增进脑活力等。近十年来，已经成为世界保健品市场最引人关注和最有前景的健品。
纳豆(Natto)是以大豆为原料，经纳豆枯草芽孢杆菌(Bacillus subtilisnatto)发酵制成的即食豆制品。纳豆富含蛋白质、有机酸、纤维素、钙、铁、多种维生素等营养物质。此外，纳豆还富含纳豆激酶、益生菌、吡啶二羧酸、血管紧张肽转化酶抑制剂、维生素K2等多种具保健功能的活性物质，这些营养成分及活性物质对人体健康有重要作用。纳豆主要盛行于日本，也流行于朝鲜、韩国及欧美国家。我国对纳豆的重视起步较晚，传统纳豆的制作以黄豆为原料，如今纳豆的原料越来越多样化，不少研究采用不同的豆类、杂粮进行发酵。这利于纳豆品种的多样化生产，满足不同人群的喜好。虽然纳豆营养价值高，但由于我国消费者对纳豆独特风味的排斥，纳豆在中国的推广并不理想。
沙棘果棘果为胡颓子科沙棘属植物沙棘(Hippophae rhamnoides L.)的果实，又名醋柳果，酸刺果。沙棘果是一种小浆果植物，落叶灌木或小乔木。沙棘是目前世界上含有天然维生素种类最多的珍贵经济林树种，其维生素C的含量远远高于鲜枣和猕猴桃，从而被誉为天然维生素的宝库。
黑枸杞含有大量的原花青素，是迄今为止，发现原花青素(OPC)含量最高的天然野生植物，OPC是最有效的天然水溶性自由基清除剂，具有很强的抗衰老作用，是一种新型高效抗氧化剂。
纳豆中所含有的纳豆激酶在强酸环境会导致活性丧失。纳豆激酶在中性、碱性环境保持稳定，一旦PH值低于5时，迅速变性失活。由于人体的胃酸环境中的PH值只有1.2到2之间，纳豆激酶在胃酸中容易失活，所以经胃消化吸收的纳豆激酶对人体来说效果较差。
发明内容
基于上述背景技术中的问题，本发明拟提供一种风味良好，能够被人体吸收，且对男性精力有保健作用的保健品食品的配方及制备。
本发明是通过以下方法来制备的：
一种玛咖纳豆激酶复合制剂，由以下组分构成：
玛咖提取物、纳豆制品、人参、寡聚糖、水溶性膳食纤维、沙棘果、黑枸杞提取物、促促生长激素。
作为优选，所述组分按以下重量份组成：玛咖提取物20-30份、纳豆制品10-20份、人参5-10份、寡聚糖2-5份、水溶性膳食纤维0.5-2份、沙棘果3-5份、黑枸杞提取物2-5份、促促生长激素0.05-0.1份。作为优选，所述组分按以下重量份组成：玛咖提取物25份、纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、黑枸杞提取物3份、促促生长激素0.08份。
制备工艺为：
(1)所述玛咖提取物的制备过程为：在新鲜玛咖中加入体积分数为30％的乙醇溶液，料液比为1:5，加热回流提取1h，最后减压、浓缩、干燥得到粉末状的玛咖提取物；
(2)所述黑枸杞提取物的制备过程为：
A:原料处理：按照重量份数取黑枸杞再去杂，洗净，置于温度为65℃的恒温干燥箱中干燥24h，粉碎后过0.2mm筛；
B:超声辅助处理:向超声仪中加入步骤(1)制得的粗粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
C:向得到的B液中加入硅藻土：海泡石重量比为5:1的吸附剂，加热至85℃，回流1h，过滤，待用，所述吸附剂质量为B液体的十分之一，干燥既得黑枸杞提取物；
(3)将纳豆破碎至200目，加入纳豆3倍体积当量的壁材羟丙基甲基纤维素酞酸酯；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为85℃，制成目数为200目的微囊制剂；制得纳豆微囊；
(4)将步骤(1)、(2)、(3)得到的玛咖提取物、黑枸杞提取物、纳豆微囊与余下的物质混合粉碎、过筛控制目数为200目；干燥制粒，既得。
所述制剂可以是片剂、压片糖果剂、固体饮料剂、胶囊、粒剂、水剂、肠溶制剂或注射剂中任意一种。
本发明的有益效果
(1)玛咖与纳豆激酶相结合是本发明首次提出，可以有效增强男性精力和耐力，加强性能力，增加受孕机率。
(2)针对纳豆激酶在胃液中容易失去活性的问题，本发明首次其做成了肠溶性微胶囊，在经过胃时不会被消化。在到达人体小肠时可以充分的释放出来。制成的微囊既可以掩盖纳豆激酶的特殊味道，更容易被接受，也可以增加吸收效果。
(3)加入黑枸杞具有极高的原花青素(OPC)含量，是最有效的天然水溶性自由基清除剂，具有抗衰老作用，提取过程设计合理，可以最大限度去除其他的杂质，得到含原花青素很高的提取物。
具体实施方式
以下实施例用于进一步阐述本发明，但不应理解为对本发明权利要求书请求保护范围的限制。
实施例1
配方为玛咖提取物25份、纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、黑枸杞提取物3份、促促生长激素0.08份。
制备工艺为：
(1)所述玛咖提取物的制备过程为：在新鲜玛咖中加入体积分数为30％的乙醇溶液，料液比为1:5，加热回流提取1h，最后减压、浓缩、干燥得到粉末状的玛咖提取物；
(2)所述黑枸杞提取物的制备过程为：
A:原料处理：按照重量份数取黑枸杞再去杂，洗净，置于温度为65℃的恒温干燥箱中干燥24h，粉碎后过0.2mm筛；
B:超声辅助处理:向超声仪中加入步骤(1)制得的粗粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
C:向得到的B液中加入硅藻土：海泡石重量比为5:1的吸附剂，加热至85℃，回流1h，过滤，待用，所述吸附剂质量为B液体的十分之一，干燥既得黑枸杞提取物；
(3)所述纳豆制品的制备方式为：将纳豆破碎至200目，加入纳豆3倍体积当量的壁材羟丙基甲基纤维素酞酸酯；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为85℃；制得纳豆微囊；
(4)将步骤(1)、(2)、(3)得到的玛咖提取物、黑枸杞提取物、纳豆微囊与余下的物质混合粉碎、过筛控制目数为200目；干燥制粒，既得。
实施例2
配方为：玛咖提取物20份、纳豆制品15份、人参5份、寡聚糖3份、水溶性膳食纤维2份、沙棘果3份、黑枸杞提取物2份、促生长激素0.08份。其制备工艺同实施例1。
实施例3
配方为：玛咖提取物30份、纳豆制品20份、人参10份、寡聚糖5份、水溶性膳食纤维2份、沙棘果5份、黑枸杞提取物2份、促生长激素0.08份，提取备工艺同实施例1。
实施例4
配方为：玛咖提取物25份、纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、黑枸杞提取物3份、促生长激素0.08份。
制备方式为：
(1)所述玛咖提取物的制备过程为：在新鲜玛咖中加入体积分数为30％的乙醇溶液，料液比为1:5，加热回流提取1h，最后减压、浓缩、干燥得到粉末状的玛咖提取物；
(2)所述黑枸杞提取物的制备过程为：
A:原料处理：按照重量份数取黑枸杞再去杂，洗净，置于温度为65℃的恒温干燥箱中干燥24h，粉碎后过0.2mm筛；
B:超声辅助处理:向超声仪中加入步骤(1)制得的粗粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；除去乙醇既得；
(3)所述纳豆制品的制备方式为：将纳豆破碎至200目；干燥得粉末既得；
(4)将步骤(1)、(2)、(3)得到的玛咖提取物、黑枸杞提取物、纳豆制品与余下的物质混合粉碎、过筛控制目数为200目；干燥制粒，既得。
实施例5
配方为：玛咖提取物25份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、促生长激素0.08份。其余制备工艺同实施例1。
实施例6
配方为：纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、黑枸杞提取物3份、促生长激素0.08份。黑枸杞提取物的制备方式为：加入6倍重量当量的浓度为65％乙醇，合并煎煮，过滤，烘干，制粒。
其余制备工艺同实施例1。
实施例7
配方为玛咖提取物25份、纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、促生长激素0.08份。其余制备工艺同实施例1。
将实施例1-7所制的制剂进行测试。
昆明小鼠，36-38g，800只雄性(约52周大)，上海实验动物中心购买。室温18-22℃，相对湿度维持在60％-70％，光照12hr∶12hr(光∶暗)，使用前适应环境3天。
药效学实验：
材料和方法：
实验材料:实施例1-7所制备的保健品。
实验动物：昆明种雄性小鼠(约52周大)
给药方法：与食品一起喂食，每天早上8点一次。
小鼠生存实验：将800只52周大小鼠随机分成8组，每组100只。
实验方法：将小鼠进行负重游泳抗疲劳测试(所负重量为小鼠自身体重10％的铁)，分别记录每组服用本产品2h后当天的游泳测试时间(s)，取平均值。结果见表1。
表1
从上表1可以看出，实施例4采用了制微囊技术，该微囊在胃部无法被消化，在小肠部消化吸收良好，与实施例1相比雄性小鼠的负重游泳能力明显下降。其原因可能是纳豆激酶在胃酸的作用下失活严重。
实施例5与实施例1相比未添加纳豆，其效果也不佳，实施例6与实施例1相比未添加玛咖，其负重效果增加了10s的时长。耐力增加不多。实施例7未添加黑枸杞提取物，对精力稍有降低。
昆明小鼠，36-38g，800只雌雄各半(26周大)，上海实验动物中心购买。室温18-22℃，相对湿度维持在60％-70％，光照12hr∶12hr(光∶暗)，使用前适应环境3天，每组雌雄小鼠各50只，给药方法：与食品一起喂食，每天早上8点一次，测试记录喂食雌性小鼠受孕率(％)，详见表2。
表2
| 1周 | 2周 | 3周 | 4周 | 5周 | |
| 实施例1 | 65％ | 83％ | 89％ | 95％ | 99％ |
| 实施例2 | 63％ | 82％ | 87％ | 96％ | 99％ |
| 实施例3 | 58％ | 78％ | 85％ | 99％ | 100％ |
| 实施例4 | 35％ | 42％ | 45％ | 52％ | 58％ |
| 实施例5 | 23％ | 35％ | 38％ | 40％ | 43％ |
| 实施例6 | 15％ | 21％ | 25％ | 31％ | 33％ |
| 实施例7 | 61％ | 72％ | 78％ | 88％ | 92％ |
| 空白组 | 10％ | 18％ | 20％ | 25％ | 29％ |
采用HPLC检测该产品实施例1-7所制的制剂的花青素含量和。结果见表3。表3
| 花青素含量(mg/kg) | |
| 实施例1 | 35 |
| 实施例2 | 33 |
| 实施例3 | 32 |
| 实施例4 | 38 |
| 实施例5 | 26 |
| 实施例6 | 12 |
| 实施例7 | 36 |
从上表可以看出，采用本发明对黑枸杞的预处理方式可以明显提高花青素的提取效果。
Claims (5)
1.一种玛咖纳豆制品复合制剂，其特征在于，由以下组分构成：
玛咖提取物、纳豆制品、人参、寡聚糖、水溶性膳食纤维、沙棘果、黑枸杞提取物、促生长激素。
2.根据权利要求1所述的复合制剂，其特征在于：上述组分按以下重量份组成：玛咖提取物20-30份、纳豆制品10-20份、人参5-10份、寡聚糖2-5份、水溶性膳食纤维0.5-2份、沙棘果3-5份、黑枸杞提取物2-5份、促生长激素00.5-0.1份。
3.根据权利要求1所述的复合制剂，其特征在于：上述组分按以下重量份组成：玛咖提取物25份、纳豆制品15份、人参6份、寡聚糖2份、水溶性膳食纤维0.5份、沙棘果4份、黑枸杞提取物3份、促生长激素0.08份。
4.根据权利要求3所述的复合制剂，其特征在于：制备工艺为：
(1)所述玛咖提取物的制备过程为：在新鲜玛咖中加入体积分数为30％的乙醇溶液，料液比为1:5，加热回流提取1h，最后减压、浓缩、干燥得到粉末状的玛咖提取物；
(2)所述黑枸杞提取物的制备过程为：
A:原料处理：按照重量份数取黑枸杞再去杂，洗净，置于温度为65℃的恒温干燥箱中干燥24h，粉碎后过0.2mm筛；
B:超声辅助处理:向超声仪中加入步骤(1)制得的粗粉，再加入6倍重量当量的浓度为65％乙醇，控制超声功率为350W、超声时间为100min；
C:向得到的B液中加入硅藻土：海泡石重量比为5:1的吸附剂，加热至85℃，回流1h，过滤，待用，所述吸附剂质量为B液体的十分之一，干燥既得黑枸杞提取物；
(3)所述纳豆制品的制备方式为：将纳豆破碎至200目，加入纳豆3倍体积当量的壁材羟丙基甲基纤维素酞酸酯；加入固化剂谷氨酰胺转氨酶，用量为壁材质量的2％；采用喷雾干燥法进行干燥制粒，控制进风温度为85℃，制成目数为200目的微囊制剂；制得纳豆微囊；
(4)将步骤(1)、(2)、(3)得到的玛咖提取物、黑枸杞提取物、纳豆微囊与余下的物质混合粉碎、过筛控制目数为200目；干燥制粒，既得。
5.根据权利要求1-4任意一项所述的复合制剂，其特征在于，所述制剂可以是片剂、压片糖果剂、固体饮料剂、胶囊、粒剂、水剂、肠溶制剂或注射剂中任意一种。
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