CN111617160A - A Chinese medicinal composition with immunity enhancing effect - Google Patents
A Chinese medicinal composition with immunity enhancing effect Download PDFInfo
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The invention belongs to the technical field of functional foods or biological medicines, and particularly relates to a traditional Chinese medicine composition with an immunity improving effect; the traditional Chinese medicine composition comprises the following raw materials: colla Corii Asini, radix astragali, radix Codonopsis, fructus Lycii, and fructus Jujubae; the traditional Chinese medicine composition has the effects of enhancing the disease resistance of a human body and improving the immunity, is an ideal health food for enhancing the immunity, and is particularly suitable for people with low immunity. The product is suitable for people with asthenia. Is also a nutritional health product suitable for young people and middle-aged and elderly people. The product has good effect, has no toxic and side effects after long-term administration, and is suitable for comprehensive maintenance and comprehensive conditioning.
Description
Technical Field
The invention relates to the technical field of functional foods or biological medicines, in particular to a traditional Chinese medicine composition for improving immunity.
Background
In the past, the reason for the disease was misguing to those bacteria and viruses, which actually only produce the disease in people with low resistance. But the real cause of acquired diseases is low resistance (medically called immunity). At birth, everyone brings the body to the world's best "doctor" -immune system. The immune system behaves as a well-trained and sophisticated army. Once the disease invades, the medicine can effectively resist to protect the body. The disease is not developed in one day and the health is not changed in one day. The body requires daily care and it is therefore important to have a correct idea.
Part of the reasons for the decline of immunity:
1. human health is vulnerable to threats, namely living in modern cities, the health of each person is vulnerable to many threats, including air pollution, water pollution, environmental pollution, working pressure, economic pressure, bacteria and viruses, improper diet, and actual restlessness! All these adverse health factors often cause a person to fail to concentrate, have poor memory, often lassitude, age early, and even die. We are not tie-up. In addition to the gradual improvement of the large environment, the functions of the immune system of the human body are enhanced to resist various adverse health factors.
2. The reason of the low immunity of the body is mainly the following aspects: mental imbalance; nutritional insufficiency; noise and depression; high buildings and air conditioners; the life is not regular; exercise is inevitable; medicines are used randomly; the life is disordered. At present, the white-collar workers and some people who take mental labor as occupations have large relative mental stress, so that the mental stress is accumulated for a long time, and the brain is overloaded and runs, thereby causing brain fatigue, further causing the immunity to be reduced, the whole body to be powerless, dizziness, palpitation, short breath, insomnia, amnesia, excessive internal heat, constipation, inappetence and the like. The immunity is reduced, and the people are easy to catch cold and epidemic diseases.
Based on the reasons, the research and development of a new product for improving the immunity have important significance.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition with immunity improving function, which is prepared from raw materials of donkey-hide gelatin, astragalus root, pilose asiabell root, medlar and Chinese date; the Chinese medicinal composition has the effects of enhancing the disease resistance of a human body and improving the immunity, is an ideal health-care food for enhancing the immunity, and is particularly suitable for people with low immunity. The product is suitable for people with asthenia. Is also a nutritional health product suitable for young people and middle-aged and elderly people. The product has good effect, has no toxic and side effects after long-term administration, and is suitable for comprehensive maintenance and comprehensive conditioning.
In the formula, the codonopsis pilosula is sweet and neutral, and has the effects of tonifying middle-jiao, replenishing qi and invigorating spleen; huang Qi is sweet and warm, and has the actions of tonifying Qi and raising Yang, reinforcing Wei and consolidating exterior. The two are reinforced by monarch drugs to make the efficacy of invigorating qi and invigorating yang more prominent, and can be used for treating uterine prolapse and proctoptosis due to qi deficiency and collapse due to qi deficiency; weakness of the spleen and stomach, poor appetite due to improper transportation and transformation, loose stool, diarrhea, lassitude and hypodynamia. Donkey-hide gelatin nourishes yin, enriches blood and stops bleeding, and medlar excels in tonifying essence and qi; the donkey-hide gelatin nourishes blood and invigorates qi, and the Chinese date tonifies spleen and stomach, and has the efficacy of nourishing blood and benefiting qi together. The health care function of enhancing the immunity of the organism is achieved by combining the medicines.
The invention is realized by the following technical scheme.
A traditional Chinese medicine composition comprises the following raw materials: colla Corii Asini, radix astragali, radix Codonopsis, fructus Lycii, and fructus Jujubae.
Wherein 40 to 60 parts of donkey-hide gelatin, 160 parts of astragalus root 140-.
Wherein the donkey-hide gelatin comprises 50 weight parts of donkey-hide gelatin, 150 weight parts of astragalus, 150 weight parts of codonopsis pilosula, 100 weight parts of wolfberry fruit and 100 weight parts of Chinese date.
Wherein the Chinese medicinal composition is prepared into a medicinal preparation.
Wherein the Chinese medicinal composition is prepared into health food.
Wherein the Chinese medicinal composition is prepared into food.
The traditional Chinese medicine composition is applied to preparing medicines or foods for improving immunity.
Wherein the Chinese medicinal composition is prepared into a medicinal preparation, food or health food, and auxiliary materials are added, wherein the auxiliary materials comprise: one or more of semen Sesami Niger, semen Juglandis, Mel, and crystal sugar.
Wherein, the weight portions of black sesame seed 60-90, walnut kernel 60-90, honey 80-120 and crystal sugar 30-50.
The product is prepared from semen Sesami Niger, semen Juglandis, Mel, and crystal sugar. Semen Sesami Niger and semen Juglandis as fragrant substances, and Mel and crystal sugar as sweetener. The black sesame has black surface and is rich in oil. Light smell, sweet taste, oil fragrance. Walnut kernel is crisp and rich in oil. Light smell, sweet taste. The black sesame, the walnut kernel, the honey and the rock candy are common auxiliary materials of the paste, the black sesame and the walnut kernel endow the product with fragrance, and the honey and the rock candy endow the product with sweet taste.
In the formula, the codonopsis pilosula is sweet and neutral, and has the effects of tonifying middle-jiao, replenishing qi and invigorating spleen; huang Qi is sweet and warm, and has the actions of tonifying Qi and raising Yang, reinforcing Wei and consolidating exterior. The two are reinforced by monarch drugs to make the efficacy of invigorating qi and invigorating yang more prominent, and can be used for treating uterine prolapse and proctoptosis due to qi deficiency and collapse due to qi deficiency; weakness of the spleen and stomach, poor appetite due to improper transportation and transformation, loose stool, diarrhea, lassitude and hypodynamia. Donkey-hide gelatin nourishes yin, enriches blood and stops bleeding, and medlar excels in tonifying essence and qi; the donkey-hide gelatin nourishes blood and invigorates qi, and the Chinese date tonifies spleen and stomach, and has the efficacy of nourishing blood and benefiting qi together. The health care function of enhancing the immunity of the organism is achieved by combining the medicines.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is further explained with the following embodiments, but the following embodiments are only the preferred embodiments of the invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention.
The experimental methods in the following examples are conventional methods unless otherwise specified, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1
40g of donkey-hide gelatin, 140g of astragalus, 140g of codonopsis pilosula, 80g of wolfberry fruit, 80g of Chinese date, 60g of black sesame, 60g of walnut kernel, 80g of honey and 30g of rock candy;
weighing the astragalus and the codonopsis pilosula in the formula amount, adding water for extraction twice, adding 10 times of water for extraction for 120min for the first time, adding 8 times of water for extraction for 120min for the second time, combining the two extracting solutions, filtering by a screen of 160 meshes, and discarding medicine residues. Concentration: concentrating the extractive solution under reduced pressure at 70 deg.C under-0.08 Mpa, and concentrating the filtrate to 1:0.8 (i.e. 1000g medicinal materials are concentrated to 800 ml) to obtain fluid extract. And (3) sol process: taking the donkey-hide gelatin according to the formula amount, crushing into small pieces, adding into 1.5 times of purified water, heating, stirring constantly to prevent the donkey-hide gelatin from pasting in a sticking pot until the donkey-hide gelatin is completely dissolved, and obtaining donkey-hide gelatin slurry for later use. And (3) a pulping process: preparation of walnut kernel and black sesame paste: the walnut kernel and the black sesame are taken according to the formula amount, cleaned, added with a proper amount of water, and passed through a pulping machine for 3 times to obtain walnut kernel and black sesame fine paste. Preparing the wolfberry fruit and jujube fine paste: cleaning fructus Jujubae and fructus Lycii, soaking in 0.5 times of purified water for more than 4 hr for softening, mixing soaking materials, and grinding with a pulping machine for 2-3 times to obtain fructus Lycii and fructus Jujubae extract. The boiling process comprises the following steps: putting the fluid extract, the donkey-hide gelatin aqueous solution, the walnut kernel and black sesame fine paste and the wolfberry fruit and Chinese date fine paste into a jacketed pan, heating, mixing and stirring uniformly, adding the formula amount of rock candy, stirring to completely dissolve, adding the honey, and decocting into a thick paste. The test content is that the content in a 200 ml bottle is not less than 240 g. The encapsulating process comprises the following steps: hot filling the paste at 70 ℃, subpackaging into transparent glass bottles with the specification of 240 g/bottle, and screwing a cap. The sterilization process comprises the following steps: flow through steam sterilization at 116 ℃ for 45 minutes.
Example 2
60g of donkey-hide gelatin, 160g of astragalus, 160g of codonopsis pilosula, 120g of wolfberry fruit, 120g of Chinese date, 90g of black sesame, 90g of walnut kernel, 120g of honey and 50g of rock candy;
weighing the astragalus and the codonopsis pilosula in the formula amount, adding water for extraction twice, adding 10 times of water for extraction for 120min for the first time, adding 8 times of water for extraction for 120min for the second time, combining the two extracting solutions, filtering by a screen of 160 meshes, and discarding medicine residues. Concentration: concentrating the extractive solution under reduced pressure at 70 deg.C under-0.08 Mpa, and concentrating the filtrate to 1:0.8 (i.e. 1000g medicinal materials are concentrated to 800 ml) to obtain fluid extract. And (3) sol process: taking the donkey-hide gelatin according to the formula amount, crushing into small pieces, adding into 1.5 times of purified water, heating, stirring constantly to prevent the donkey-hide gelatin from pasting in a sticking pot until the donkey-hide gelatin is completely dissolved, and obtaining donkey-hide gelatin slurry for later use. And (3) a pulping process: preparation of walnut kernel and black sesame paste: the walnut kernel and the black sesame are taken according to the formula amount, cleaned, added with a proper amount of water, and passed through a pulping machine for 3 times to obtain walnut kernel and black sesame fine paste. Preparing the wolfberry fruit and jujube fine paste: cleaning fructus Jujubae and fructus Lycii, soaking in 0.5 times of purified water for more than 4 hr for softening, mixing soaking materials, and grinding with a pulping machine for 2-3 times to obtain fructus Lycii and fructus Jujubae extract. The boiling process comprises the following steps: putting the fluid extract, the donkey-hide gelatin aqueous solution, the walnut kernel and black sesame fine paste and the wolfberry fruit and Chinese date fine paste into a jacketed pan, heating, mixing and stirring uniformly, adding the formula amount of rock candy, stirring to completely dissolve, adding the honey, and decocting into a thick paste. The test content is that the content in a 200 ml bottle is not less than 240 g. The encapsulating process comprises the following steps: hot filling the paste at 70 ℃, subpackaging into transparent glass bottles with the specification of 240 g/bottle, and screwing a cap. The sterilization process comprises the following steps: flow through steam sterilization at 116 ℃ for 45 minutes.
Example 3
50g of donkey-hide gelatin, 150g of astragalus, 150g of codonopsis pilosula, 100g of wolfberry fruit, 100g of Chinese date, 75g of black sesame, 75g of walnut kernel, 100g of honey and 40g of rock candy;
weighing the astragalus and the codonopsis pilosula in the formula amount, adding water for extraction twice, adding 10 times of water for extraction for 120min for the first time, adding 8 times of water for extraction for 120min for the second time, combining the two extracting solutions, filtering by a screen of 160 meshes, and discarding medicine residues. Concentration: concentrating the extractive solution under reduced pressure at 70 deg.C under-0.08 Mpa, and concentrating the filtrate to 1:0.8 (i.e. 1000g medicinal materials are concentrated to 800 ml) to obtain fluid extract. And (3) sol process: taking the donkey-hide gelatin according to the formula amount, crushing into small pieces, adding into 1.5 times of purified water, heating, stirring constantly to prevent the donkey-hide gelatin from pasting in a sticking pot until the donkey-hide gelatin is completely dissolved, and obtaining donkey-hide gelatin slurry for later use. And (3) a pulping process: preparation of walnut kernel and black sesame paste: the walnut kernel and the black sesame are taken according to the formula amount, cleaned, added with a proper amount of water, and passed through a pulping machine for 3 times to obtain walnut kernel and black sesame fine paste. Preparing the wolfberry fruit and jujube fine paste: cleaning fructus Jujubae and fructus Lycii, soaking in 0.5 times of purified water for more than 4 hr for softening, mixing soaking materials, and grinding with a pulping machine for 2-3 times to obtain fructus Lycii and fructus Jujubae extract. The boiling process comprises the following steps: putting the fluid extract, the donkey-hide gelatin aqueous solution, the walnut kernel and black sesame fine paste and the wolfberry fruit and Chinese date fine paste into a jacketed pan, heating, mixing and stirring uniformly, adding the formula amount of rock candy, stirring to completely dissolve, adding the honey, and decocting into a thick paste. The test content is that the content in a 200 ml bottle is not less than 240 g. The encapsulating process comprises the following steps: hot filling the paste at 70 ℃, subpackaging into transparent glass bottles with the specification of 240 g/bottle, and screwing a cap. The sterilization process comprises the following steps: flow through steam sterilization at 116 ℃ for 45 minutes.
The traditional Chinese medicine composition comprises the following components:
the colla Corii Asini is a glue block prepared by dehairing skin of Equus asinus L. Sweet in flavor and neutral in nature. Enter lung, liver and kidney meridians. The functions are as follows: enriching blood, stopping bleeding, nourishing yin, moistening lung, and preventing miscarriage. The main treatment is as follows: blood deficiency, cough due to asthenia, hematemesis, epistaxis, hematochezia, menoxenia, metrorrhagia, and fetal leakage. The donkey-hide gelatin has the effects of protecting lung qi, nourishing liver blood, tonifying deficiency, stopping bleeding, preventing miscarriage, relieving cough and dysentery, treating phlegm and curing atrophy. It is indicated for chronic cough, chronic dysentery, chronic phlegm, consumptive disease and bleeding. The oral administration is as follows (medicine identification): melting yellow wine or boiled water, 3-9 g.
Fructus Lycii is dried mature fruit of Lycium barbarum L. Harvesting fruits in summer and autumn when the fruits are orange red, drying until the skin is wrinkled, solarizing until the skin is dry and hard and the pulp is soft, and removing fruit stalks; or hot air drying at low temperature to remove fruit stalks. Wolfberry fruit, fructus Lycii, sweet and neutral. It enters liver and kidney meridians. Nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating asthenia, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision. The tonic effect of medlar is very important for health preserving families and medical scientists in all ages. As early as in Shen nong Ben Cao Jing, it is pointed out that: strengthening the muscles and bones after long-term administration; "Ming Yi Bie Lu" (famous medical records) is good at tonifying essence and qi; the recorded Chinese wolfberry in the dietetic herbal medicine can benefit the people and remove consumptive disease. Oral administration: 6-12 g.
Radix Codonopsis is root of Codonopsis pilosula (Franch.) Nannf. Also named as Shang Dang Ginseng (the origin of meridian). Sweet in flavor and neutral in nature. Enter spleen and lung meridians. The functions are as follows: tonify middle warmer, replenish qi, and promote fluid production. The main treatment is as follows: weakness of spleen and stomach, deficiency of both qi and blood, tiredness, weakness, poor appetite, thirst, chronic diarrhea, and rectocele. Oral administration: decoct 9-15 g.
The radix astragali is dried root of Astragalus membranaceus (Fisch.) bge. of Leguminosae or Astragalus mongholicus bge. of inner Mongolia. Also named Huang Qi (Ben Jing) and mian Huang Qi (Ben Cao Tu Jing). Sweet in flavor and slightly warm in nature. Enter lung and spleen meridians. Unprocessed: benefiting defense, consolidating superficial resistance, inducing diuresis to alleviate edema, expelling toxin, and promoting granulation. The main treatment is as follows: spontaneous perspiration, night sweat, blood arthralgia, edema, carbuncle and deep-rooted carbuncle can not be ulcerated or ulcerated for a long time. Roasting: tonify middle-jiao and Qi. The main treatment is as follows: internal injury, fatigue, diarrhea due to spleen deficiency, rectocele, qi deficiency, blood collapse, and all syndromes due to qi deficiency and blood deficiency. Oral administration: decoct 9-15 g.
The fructus Jujubae is mature fruit of Ziziphus jujuba Mill. var. inermis (Bge.) Rehd. of Rhamnaceae. Also named as fructus Jujubae (entry of medical science), dried fructus Jujubae (miscellaneous records of famous physicians), etc. Sweet in flavor and warm in nature. Enter spleen and stomach meridians. The functions are as follows: invigorating spleen, regulating stomach function, invigorating qi, promoting fluid production, regulating ying and wei, and relieving drug toxicity. The main treatment is as follows: stomach deficiency, poor appetite, spleen weakness, loose stool, deficiency of qi, blood and body fluids, disharmony between ying and wei, palpitation, and irritability of women. Oral administration: decoct 6-15 g.
In the formula, the codonopsis pilosula is sweet and neutral, and has the effects of tonifying middle-jiao, replenishing qi and invigorating spleen; huang Qi is sweet and warm, and has the actions of tonifying Qi and raising Yang, reinforcing Wei and consolidating exterior. The two are mutually reinforced to ensure that the efficacy of tonifying qi and invigorating yang is more remarkable, and the medicine is used for treating uterine prolapse and proctoptosis caused by deficiency of middle-qi and sinking of qi; weakness of the spleen and stomach, poor appetite due to improper transportation and transformation, loose stool, diarrhea, lassitude and hypodynamia. Donkey-hide gelatin nourishes yin, enriches blood and stops bleeding, and medlar excels in tonifying essence and qi; the donkey-hide gelatin nourishes blood and invigorates qi, and the Chinese date tonifies spleen and stomach, and has the efficacy of nourishing blood and benefiting qi together. The health care function of enhancing the immunity of the organism is achieved by combining the medicines.
Test examples
Test example 1
Influence on spleen lymphocyte transformation of immunocompromised mice
The test method comprises the following steps: taking BALB/C male mice with the weight of 18-20g, randomly grouping, modeling the mice with low immunity, not modeling the normal group, starting administration when the modeling is successful, and administering 0.2ml/20g of physiological saline to the control group. Examples 1-3 groups were administered by gastric gavage at a dose of 2g crude drug/kg for 30 days, mice were sacrificed by decapitation 24 hours after drug withdrawal, spleens were removed under aseptic conditions, spleen cell suspensions were prepared from 1640 culture medium (containing 10% calf serum), mouse spleen cells were adjusted to 5X 106 cells/ml and added to 96-well plates at 100. mu.l per well, and each well was divided into two portions (i.e., one with ConA and one without ConA). ConA 20. mu.l (concentration: 1000. mu.g/ml), 1640 medium 80. mu.l, in a volume of from 200. mu.l per well, was incubated at 5% CO237 ℃ for 72 hours in an incubator, and 3H-TdR3.7X 109 (iucr) was added to each well 24 hours before termination of the incubation. The cells were harvested on a type 49 glass fiber filter paper using a cell harvester (TITERTEK CELLHARVESTER 550), washed sequentially with distilled water, 5% triamineacetic acid, and absolute ethanol, the filter paper was dried in an incubator at 60 ℃, added to a cup containing 5ml of scintillation fluid, measured for radioactivity (cpm) by a liquid scintillation counter (BECKMEN LS 9800), and the Stimulation Index (SI) was calculated, i.e., SI = add/no-add ConA well cpm.
And (3) test results: see table 1.
Table 1 effect on splenic lymphocyte transformation in immunocompromised mice.
| Group of | SI |
| Normal group | 0.685±0.028** |
| Control group | 0.139±0.016 |
| EXAMPLE 1 group | 2.503±0.095** |
| EXAMPLE 2 group | 2.749±0.134** |
| EXAMPLE 3 group | 2.480±0.104** |
| EXAMPLE 3 group | 2.480±0.104** |
Note: p <0.01 compared to control group.
And (3) knotting: the composition can obviously increase the spleen lymphocyte transformation of mice with low immunity (compared with a control group, P is less than 0.01), and has good function of improving immunity.
The foregoing is a preferred embodiment of the present invention, and is not intended to limit the invention in any way, so that modifications and equivalents may be made thereto without departing from the spirit and scope of the invention.
Claims (9)
1. A traditional Chinese medicine composition is characterized by comprising the following raw materials: colla Corii Asini, radix astragali, radix Codonopsis, fructus Lycii, and fructus Jujubae.
2. The composition as claimed in claim 1, wherein the composition comprises colla Corii Asini 40-60, radix astragali 140-160, radix Codonopsis 140-160, fructus Lycii 80-120 and fructus Jujubae 80-120.
3. The Chinese medicinal composition according to claim 1, wherein the composition comprises colla Corii Asini 50 weight parts, radix astragali 150 weight parts, radix Codonopsis 150 weight parts, fructus Lycii 100 weight parts, and fructus Jujubae 100 weight parts.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared into a pharmaceutical preparation.
5. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared into a health food.
6. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared as a food.
7. Use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a medicament or food for enhancing immunity.
8. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared into a medicinal preparation, a food or a health food, and is added with auxiliary materials, wherein the auxiliary materials comprise: one or more of semen Sesami Niger, semen Juglandis, Mel, and crystal sugar.
9. The traditional Chinese medicine composition according to claim 8, wherein 60-90 parts by weight of black sesame, 60-90 parts by weight of walnut kernel, 80-120 parts by weight of honey and 30-50 parts by weight of rock candy.
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