CN1115212A - Method for prodn. of chewing gum and bubble gum for prevention and treatment of decayed tooth and periodontitis - Google Patents
Method for prodn. of chewing gum and bubble gum for prevention and treatment of decayed tooth and periodontitis Download PDFInfo
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- CN1115212A CN1115212A CN 94116766 CN94116766A CN1115212A CN 1115212 A CN1115212 A CN 1115212A CN 94116766 CN94116766 CN 94116766 CN 94116766 A CN94116766 A CN 94116766A CN 1115212 A CN1115212 A CN 1115212A
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- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 11
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 9
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 title claims description 5
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 title claims description 5
- 235000010634 bubble gum Nutrition 0.000 title claims description 5
- 201000001245 periodontitis Diseases 0.000 title abstract description 7
- 230000002265 prevention Effects 0.000 title description 3
- 239000000284 extract Substances 0.000 claims abstract description 25
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000010447 xylitol Nutrition 0.000 claims abstract description 10
- 239000000811 xylitol Substances 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 10
- 229960002675 xylitol Drugs 0.000 claims abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 4
- 229930006000 Sucrose Natural products 0.000 claims abstract description 4
- 244000269722 Thea sinensis Species 0.000 claims abstract description 4
- 239000000654 additive Substances 0.000 claims abstract description 4
- 230000000996 additive effect Effects 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 3
- 239000008103 glucose Substances 0.000 claims abstract description 3
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
- 230000000274 adsorptive effect Effects 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 229940013618 stevioside Drugs 0.000 claims description 4
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019202 steviosides Nutrition 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 235000013599 spices Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims 2
- 102100026194 C-type lectin domain family 2 member B Human genes 0.000 claims 1
- 241000723347 Cinnamomum Species 0.000 claims 1
- 244000037185 Cinnamomum burmannii Species 0.000 claims 1
- 235000014487 Cinnamomum burmannii Nutrition 0.000 claims 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 claims 1
- 241000107513 Cinnamomum subavenium Species 0.000 claims 1
- 241000917739 Cinnamomum wilsonii Species 0.000 claims 1
- 241000202807 Glycyrrhiza Species 0.000 claims 1
- 244000303040 Glycyrrhiza glabra Species 0.000 claims 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 claims 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000912618 Homo sapiens C-type lectin domain family 2 member B Proteins 0.000 claims 1
- 240000004580 Magnolia hypoleuca Species 0.000 claims 1
- 241001673966 Magnolia officinalis Species 0.000 claims 1
- 241000721570 Melaphis Species 0.000 claims 1
- 241001516602 Schlechtendalia chinensis Species 0.000 claims 1
- 235000006468 Thea sinensis Nutrition 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 235000019605 sweet taste sensations Nutrition 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 239000004902 Softening Agent Substances 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
- 244000228451 Stevia rebaudiana Species 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000003205 fragrance Substances 0.000 abstract 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 description 8
- 238000001914 filtration Methods 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 5
- 241000194019 Streptococcus mutans Species 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000015111 chews Nutrition 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000401 methanolic extract Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- -1 each 6 hours Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 238000003808 methanol extraction Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Confectionery (AREA)
Abstract
The chewing gum in different fragrance types for preventing and curing decayed tooth and periodontitis is made of medical additive (extract from cassia bark and tea), sweetening agent (stevia rebaudinum sugar and xylitol instead of cane sugar and glucose), softening agent, antioxidant, gum and essence.
Description
The invention belongs to a kind of prevention and treatment dental caries and the chewing gum of periodontitis and the method for production of bubble gum, specifically its leftover bits and pieces of relating to glycyrrhizic legume, Magnoliacea plant Cortex Magnoliae Officinalis, times Aphidiadae insecticide Galla Chinensis, canella Cortex cinnamomi japonici (Ramulus Cinnamomi) and Folium Camelliae sinensis is a raw material, through the science refine, and make sweeting agent with stevioside or xylitol, substitute sucrose and glucose in the traditional handicraft, be processed into the chewing gum that to prevent and treat dental caries and periodontitis and the method for production of bubble gum.
In Finland, once carried out the test of a caries prevention, medical personnel replaces common sucrose with xylitol, join in the chewing gum that the child likes eating, found that the child who chews two xylitol chewing gum every day compares with other children, the incidence rate of dental caries has reduced by 30%, the child who chews 3 xylitol chewing gum every day then reduces by 60%, (report in " Chinese health information newspaper " on June 13rd, 1).
The object of the present invention is to provide and a kind ofly not only can prevent, and can also treat the method for production of novel therapeutic type mouth perfume (or spice) (bubble) sugar of dental caries and periodontitis.
Purpose of the present invention can reach by following method: Cortex Magnoliae Officinalis, Galla Chinensis, Radix Glycyrrhizae are pulverized, extract 2-3 time with ethanol or methanol eddy, be no more than 6 hours at every turn, extract temperature and be no more than 120 ℃, pressure is no more than 4 atmospheric pressure, and extracting liquid filtering is condensed into dry extract, to grind powder stand-by.Cortex cinnamomi japonici (Ramulus Cinnamomi) is pulverized, and less than 20 organic solvent reflux, extract, 24 hours, the extraction temperature was no more than 80 ℃ with ε value, and pressure is no more than 2 atmospheric pressure; Residue extracts 2-3 times greater than 26 solvent refluxing with the ε value, extracts temperature and is no more than 120 ℃, and extraction time is no more than 6 hours, and pressure is no more than 4 atmospheric pressure, extracting liquid filtering, concentrate dry extract, it is stand-by to grind powder.With low and middle-grade green tea end, add 100 ℃ of boiling water stirring and leaching that are no more than 10 times of amounts and be no more than 1 hour, lixiviate 1-3 times, the extracting solution after the filtration adds an amount of ALCL
3, use 1mol/LNaHCO
3Transfer PH complete, centrifugalize to precipitation.Precipitation is changeed molten back equal volume of ethyl acetate with 4-6mol/L hydrochloric acid, concentrates the precipitation matchmaker after vacuum drying makes the near-white coarse crystallization.Tea extract DA-201 macroporous adsorptive resins of also can flowing through, water lotion and effluent merge, and go up the H103 macroporous adsorptive resins again, after the washing, two posts are each got 5 flow points respectively with 25%, 50%, 75%, 95% ethanol and acetone gradient elution, and merging flow point, spray drying get dry product.
With dry fine powder 50-4000 grams of above-mentioned five kinds of extracts, commercially available xylitol 1000-4000 grams and stevioside 10-80 grams, drop into fragrant (bubble) sugar of mouth of the various odor types of producing behind softening agent, antioxidant, starch, gum base and the edible essence uniform mixing by the amount of producing thousand (sheets), than having five big advantages with xylitol as additive merely:
One, bacteriostasis is extremely strong: synthetic to Streptococcus mutans and the catalytic glucosan of GTF institute as the methanolic extract of Radix Glycyrrhizae, when concentration during at 50-200mg/ml, suppression ratio reaches 100%.(Namba?T，etal?Shoyakugaku?Zasshi，1985，39(2)：146)。
Two, bacteriostasis is rapid: the methanolic extract as Cortex Magnoliae Officinalis can be killed the oral cavity Streptococcus mutans in the half at two minutes, and general mouthful of fragrant (bubble) sugar in the mouth time of chewing all more than three minutes, thereby once just cariogenic bacteria can be killed.(Wu Aiju, etc.Stomatology 1987,7 (1): 1).
Three, antimicrobial spectrum is wide: above-mentioned five kinds of extracts are to Streptococcus mutans, and dental plaque forms and the growth of periodontal bacteroid all has wide model inhibitory action.
Four, above-mentioned five kinds of extracts all derive from daily spice, beverage and conventional Chinese medicine, therefore to nontoxic pair of effect of human body.
Five, said extracted thing natural resources are very abundant; especially can be with the low-grade tea processing and utilization; raw material is inexpensive; simpler than xylitol extraction process; be convenient to large-scale production; product price is no more than the price of commercially available common chewing gum at present; but have two the most common oral diseases of control; thereby protected human especially numerous children's oral hygiene effectively, dental caries and the periodontitis of World Health Organization (WHO) being classified as one of the three big diseases of global keypoint control have played positive impetus.
Therefore, the present invention has reached purpose, and has the technological progress of highly significant.
Below be one embodiment of the present of invention:
Cortex cinnamomi japonici (Ramulus Cinnamomi) 500 grams are pulverized, extract 4 times with 5 liters of hexanes, each 6 hours, extract 65 ℃ of temperature, remove quintessence oil.Add 10 liters of 50% ethanol in the residue and extract each 1 hour 3 times in 80 ℃.Extracting liquid filtering, concentrating under reduced pressure is dry that dry product 35 restrains.
With Cortex Magnoliae Officinalis 200 gram, Radix Glycyrrhizae S0 gram pulverizes altogether, with 4 liters of methanol extraction 3 times, and each 1 hour, extract 90 ℃ of temperature, extracting liquid filtering, concentrating under reduced pressure is dry that dry product 30 restrains.
Said extracted thing 65 grams are pulverized, added xylitol 500 grams, stevioside 2 grams drop into softening agent, antioxidant, starch, gum base and edible essence by thousand volumes of production, produce routinely, sterilize and pack, promptly.This chewing gum has fast, thoroughly kills the function that the oral cavity causes dental caries and periodontal disease antibacterial.
Claims (8)
1, the method for production of a kind of mouthful of perfume (or spice) (bubble) sugar, the invention is characterized in Cortex Magnoliae Officinalis (comprising Magnolia Officinalis and M.obovata), Glycyrrhiza (comprises Glycyrrhiza uralensis Fisch, 18 kinds such as Glycyrrhiza glabra L), Galla Chinensis (insect gall of Melaphischinensis (Bell) Baker and Melaphis peitan Tsai et Tang), Cortex cinnamomi japonici (Ramulus Cinnamomi) (comprises Cinnamomum chingii Metcalf, Cinnamomum japonicumSieb, Cinnamomum burmannii (Nees) BI, Cinnamomum Wilsonii Gamble and Cinnamomum cassia Presl), Folium Camelliae sinensis (Camellia sinensis O, Ktze) be raw material, with raw material drying, directly or through pulverizing, with the ε value is organic solvent between 26-34, pressure is 1-2 atmospheric pressure (gauge pressures), temperature is 1-130 ℃ and extracts 1-6 times down, filter to get filtrate, filtrate is through reclaiming solvent, dry below 80 ℃, make the control additive.
2, in accordance with the method for claim 1, it is characterized in that the organic solvent that Cortex Magnoliae Officinalis, Radix Glycyrrhizae are adopted is a methanol, extract temperature and be 1-105 ℃ that pressure is 0.1-5 atmospheric pressure.
3, in accordance with the method for claim 1, it is characterized in that the organic solvent that Galla Chinensis adopts is an ethanol, extract temperature and be 1-120 ℃ that pressure is 0.1-5 atmospheric pressure.
4, in accordance with the method for claim 1, it is characterized in that it is water that Folium Camelliae sinensis adopts the extraction solvent, extract 10-100 ℃ of temperature, pressure is normal pressure, with AICL
3Being precipitant, is extractant with the ethyl acetate.
5, in accordance with the method for claim 4, it is characterized in that Folium Camelliae sinensis hot water extraction liquid stream is through DA-201 macroporous adsorptive resins, water lotion and effluent merge, go up the H103 macroporous adsorptive resins again, after the washing, two posts are respectively with 25%, 50%, 75%, 95% ethanol and acetone eluting, gained flow point concentrating under reduced pressure, freezing or spray drying.
6, in accordance with the method for claim 1, it is characterized in that the present invention can also only do the control agent with the single extract and produce, or mixed production afterwards with other kind extract with Cortex cinnamomi japonici (Ramulus Cinnamomi) extract.
7, in accordance with the method for claim 1, it is characterized in that Cortex cinnamomi japonici (Ramulus Cinnamomi) is directly with 50-100 ℃ of water normal pressures lixiviate 1-3 times.Or with the ε value less than 21 organic solvent extraction 1-4 times, extract 40-70 ℃ of temperature, oil removing; Residue extracts 1-3 times under 10-120 ℃ of temperature with 30%-70% ethanol.
8, special cylinder of the present invention is to be control additive or sweeting agent with the xylitol, is the sweet taste corrigent with the stevioside, and comes processing chewing gum and bubble gum with sucrose in its alternative traditional handicraft and glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94116766 CN1115212A (en) | 1994-07-19 | 1994-07-19 | Method for prodn. of chewing gum and bubble gum for prevention and treatment of decayed tooth and periodontitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94116766 CN1115212A (en) | 1994-07-19 | 1994-07-19 | Method for prodn. of chewing gum and bubble gum for prevention and treatment of decayed tooth and periodontitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1115212A true CN1115212A (en) | 1996-01-24 |
Family
ID=5038079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94116766 Pending CN1115212A (en) | 1994-07-19 | 1994-07-19 | Method for prodn. of chewing gum and bubble gum for prevention and treatment of decayed tooth and periodontitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1115212A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| JP2009114101A (en) * | 2007-11-05 | 2009-05-28 | Kazuo Nagai | Pharmaceutical composition, oral hygiene agent, and food composition for prevention or treatment of periodontal disease |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
-
1994
- 1994-07-19 CN CN 94116766 patent/CN1115212A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| JP2009114101A (en) * | 2007-11-05 | 2009-05-28 | Kazuo Nagai | Pharmaceutical composition, oral hygiene agent, and food composition for prevention or treatment of periodontal disease |
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