CN111449993A - Foam type low-carbon alcohol system hand disinfectant and preparation method thereof - Google Patents
Foam type low-carbon alcohol system hand disinfectant and preparation method thereof Download PDFInfo
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- CN111449993A CN111449993A CN202010341849.0A CN202010341849A CN111449993A CN 111449993 A CN111449993 A CN 111449993A CN 202010341849 A CN202010341849 A CN 202010341849A CN 111449993 A CN111449993 A CN 111449993A
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- foam
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- hand disinfectant
- carbon alcohol
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 83
- 239000006260 foam Substances 0.000 title claims abstract description 54
- 239000000645 desinfectant Substances 0.000 title claims abstract description 52
- 229910052799 carbon Inorganic materials 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 15
- 239000003899 bactericide agent Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004088 foaming agent Substances 0.000 claims abstract description 14
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 3
- -1 polydimethylsiloxane Polymers 0.000 claims description 25
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 17
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 5
- PAFRZNKCTXARNY-UHFFFAOYSA-M didecyl-(2-hydroxyethyl)-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(CCO)CCCCCCCCCC PAFRZNKCTXARNY-UHFFFAOYSA-M 0.000 claims description 4
- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 claims description 3
- ZIGNHCMXSPSCSO-UHFFFAOYSA-M didecyl-(3-hydroxypropyl)-methylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(CCCO)CCCCCCCCCC ZIGNHCMXSPSCSO-UHFFFAOYSA-M 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 25
- 230000001954 sterilising effect Effects 0.000 abstract description 13
- 241000894006 Bacteria Species 0.000 abstract description 10
- 241000711573 Coronaviridae Species 0.000 abstract description 7
- 241000709661 Enterovirus Species 0.000 abstract description 7
- 230000000840 anti-viral effect Effects 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 7
- 241000712461 unidentified influenza virus Species 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 6
- 238000010998 test method Methods 0.000 abstract description 6
- 241000192125 Firmicutes Species 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000009471 action Effects 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 238000007655 standard test method Methods 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 230000008030 elimination Effects 0.000 description 4
- 238000003379 elimination reaction Methods 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- JCZPMGDSEAFWDY-SQOUGZDYSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide Chemical compound NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO JCZPMGDSEAFWDY-SQOUGZDYSA-N 0.000 description 1
- RIAJTMUAPNIDSS-UHFFFAOYSA-N 3-aminopropan-1-ol;hydron;chloride Chemical compound Cl.NCCCO RIAJTMUAPNIDSS-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- ITFDXZLLAMYMBM-UHFFFAOYSA-N [Br-].[NH4+].[NH4+].C(CCCCCCCCCCC)C(=CC)C.[Br-] Chemical compound [Br-].[NH4+].[NH4+].C(CCCCCCCCCCC)C(=CC)C.[Br-] ITFDXZLLAMYMBM-UHFFFAOYSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000008149 soap solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/893—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by an alkoxy or aryloxy group, e.g. behenoxy dimethicone or stearoxy dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a foam type low-carbon alcohol system hand disinfectant and a preparation method thereof. The hand disinfectant consists of the following raw materials in percentage by weight: 40-65% of ethanol, 0.1-20% of isopropanol, 0.1-5% of foaming agent, 0.01-3% of foam stabilizer, 0.5-2% of glycerol or diglycerol, 0.1-1% of bactericide and the balance of water. Firstly adding ethanol and isopropanol into a mixing tank, then adding glycerin or diglycerol, a bactericide and water, finally adding a foaming agent and a foam stabilizer into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant. The hand disinfectant provided by the invention has high foam stability, and the sterilization rate of gram-positive bacteria, gram-negative bacteria and drug-resistant bacteria reaches 99.9 percent when the hand disinfectant is tested according to a quantitative sterilization test method in disinfection technical Specification (2002 edition) of Ministry of health; the antiviral activity rate of the antiviral activity of the antiviral agent on enterovirus, influenza virus and novel coronavirus reaches 99 percent according to an ASTM E2011-2009 test.
Description
Technical Field
The invention belongs to the field of disinfectants, and particularly relates to a foam type low-carbon alcohol system hand disinfectant and a preparation method thereof.
Background
Daily hygiene and disinfection of hands are beneficial to public health, and the medical staff's hand hygiene code clearly stipulates that soap (soap solution) and running water are used to wash hands when the hands have macroscopic pollution such as blood or other body fluids; when the hands are not polluted by naked eyes, the quick-drying hand disinfectant is preferably used for disinfecting the hands instead of washing the hands. Among them, alcohol-based hand disinfectants are the most used variety. At present, the quick-drying hand disinfectant is mainly prepared by taking ethanol as a solvent, and the product forms of the quick-drying hand disinfectant mainly include two types: spray type and gel type. The spray type alcohol hand disinfectant has low viscosity, and is not comprehensive in disinfection due to excellent fluidity, easy slipping from hands and short action time; the gel-type product is a new product developed to overcome the drawbacks of the spray-type product, and although the gel-type product can be applied to hands for a long time, the gel-type product gives a sticky feeling to the hands after use due to the characteristics of the thickener. The traditional disinfectant has short disinfection time, and the specific environment affects the disinfection effect of bacteria and viruses.
The foam disinfectant is a novel disinfectant product, is essentially different from a common disinfectant, converts a liquid disinfectant into a gas-phase foam form through a foam generating device and adheres to the surface of an object, and removes a biological film on the surface of the object through the action modes of wetting, emulsifying, permeating, dispersing, solubilizing and the like after the foam disinfectant is contacted with the surface to be disinfected so as to prolong the disinfection time and achieve the aim of deep cleaning and disinfection. However, the foam type alcohol disinfectant in the market is mainly aerosol type foam type alcohol disinfectant [ journal of preventive medicine of liberty military, 1992, 10 (1), 10 ], although the foam is abundant, the disinfectant and the propellant need to be packaged together in a pressure-resistant container with a special valve system, the preparation process is complex and the cost is high. In recent years, chinese patent CN 109288728A, US patent US 7651990B 2 and US201104079a1 respectively report that an atmospheric foam type alcohol disinfectant is prepared by adding organosilicon or organic fluorine as a foaming agent into alcohol, but the foam stability is poor, and the problem of drug resistance generated by using alcohol for many years cannot be solved.
Disclosure of Invention
The invention aims to provide a foam type low-carbon alcohol system hand disinfectant and a preparation method thereof, the disinfectant has high foam stability, the sterilization rate of gram-positive bacteria, gram-negative bacteria and the like reaches 99.999 percent, and the activity rate of resisting viruses such as enterovirus, influenza virus, novel coronavirus and the like reaches 99 percent.
The invention mainly adds the special foaming agent for the low-carbon alcohol system and the corresponding foam stabilizer, so that the low-carbon alcohol system can generate rich and fine stable foam, meanwhile, the mixed alcohol and the novel bactericide are used for effectively reducing the drug resistance, and the action time of the alcohol and the bactericide is prolonged under the synergistic action of the mixed alcohol and the novel bactericide. After the foam is formed, the foam is adhered to the surface of the hand, and the surface tension between solid and liquid is reduced through relatively complicated physical action and chemical action such as wetting, permeation, dispersion, solubilization and the like, so that the organic matter biomembrane on the surface of the hand is decomposed; meanwhile, bacteria and viruses on the surface and in the gaps are killed and disinfected through the alcohol and the bactericide.
The invention provides a foam type low-carbon alcohol system hand disinfectant, which consists of the following raw materials in percentage by weight:
40-65% of ethanol, 0.1-20% of isopropanol, 0.1-5% of foaming agent, 0.01-3% of foam stabilizer, 0.5-2% of glycerol or diglycerol, 0.1-1% of bactericide and the balance of water.
The foaming agent is an organic silicon foaming agent and comprises one or a mixture of more of PEG-n polydimethylsiloxane (wherein PEG is polyoxyethylene ether, and the polymerization number n = 4-20), bis-PEG-n polydimethylsiloxane (wherein n = 4-20), glucamide polydimethylsiloxane and bis-glucamide polydimethylsiloxane.
The foam stabilizer is one or a mixture of sodium polyacrylate and alkanolamide.
The bactericide is one or a mixture of didecyl methyl hydroxyethyl ammonium chloride, didecyl methyl hydroxypropyl ammonium chloride, didecyl methyl ammonium formate, didecyl methyl hydroxyethyl ammonium acetate and (didodecyldimethyl) ethylene diammonium bromide.
In the formula, the foaming agent can enable a low-carbon alcohol system to generate rich and fine foam, the mixed alcohol and the novel bactericide are used for effectively reducing the drug resistance, the foam stabilizer is added to increase the stability of the alcohol foam, and the action time of the alcohol and the bactericide is prolonged.
The preparation method of the foam type low-carbon alcohol system hand disinfectant comprises the following steps: firstly adding ethanol and isopropanol into a mixing tank, then adding glycerin or diglycerol, a bactericide and water, finally adding a foaming agent and a foam stabilizer into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant.
The application method of the foam type low-carbon alcohol system hand disinfectant comprises the following steps: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
The invention has the beneficial effects that:
the hand sanitizer provided by the invention has high foam stability, and prolongs the action time of alcohols and bactericides. Testing with a Roche foam tester according to GB/T7462, wherein the foam height is more than 280mm in time; according to a quantitative sterilization test method in the disinfection technical Specification (2002 edition) of the Ministry of health, the sterilization rate of the antibacterial agent to staphylococcus aureus, escherichia coli and drug-resistant bacteria reaches 99.999 percent; the antiviral activity rate against enteroviruses, influenza viruses and novel coronaviruses was 99.0% as tested according to ASTM E2011-2009 (standard test methods for evaluating manual wash methods and hand rub formulations all for manual elimination of viral activity).
Detailed Description
The present invention is further illustrated by, but is not limited to, the following examples.
Example 1:
a foam-type low-carbon alcohol system hand disinfectant comprises, by weight, 50% of ethanol, 20% of isopropanol, 0.5% of PEG-10 polydimethylsiloxane, 0.5% of glycerol, 0.1% of sodium polyacrylate, 1% of didecyl methyl hydroxyethyl ammonium chloride and the balance of water.
The preparation method of the alcohol disinfectant comprises the steps of adding ethanol and isopropanol into a mixing tank, adding glycerol, didecyl methyl hydroxyethyl ammonium chloride and water, adding PEG-10 polydimethylsiloxane and sodium polyacrylate into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant. The foam height was 330mm in time and 210mm in 3 minutes as measured by a Roche foam tester according to GB/T7462. According to a quantitative sterilization test method in the disinfection technical Specification (2002 edition) of the Ministry of health, the sterilization rate of the antibacterial agent to staphylococcus aureus, escherichia coli and drug-resistant bacteria reaches 99.999 percent; the antiviral activity rate against enteroviruses, influenza viruses and novel coronaviruses was 99.1% as tested according to ASTM E2011-2009 (standard test methods for evaluating manual wash methods and hand rub formulations all for manual elimination of viral activity).
The using method comprises the following steps: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
Example 2
A foam-type low-carbon alcohol system hand disinfectant comprises, by weight, 60% of ethanol, 10% of isopropanol, 3% of bis-PEG-12 polydimethylsiloxane, 1.5% of diglycerol, 1% of alkanolamide, 0.5% of bis (dodecyl dimethyl) ethylene diammonium bromide, and the balance of water.
The preparation method of the alcohol disinfectant comprises the steps of adding ethanol and isopropanol into a mixing tank, adding diglycerol, brominated (didodecyldimethyl) ethylene diammonium and water, adding PEG-10 polydimethylsiloxane and alkanolamide into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant. The foam height was 310mm in time and 215mm in 3 minutes, as measured by a Roche foam tester according to GB/T7462. According to a quantitative sterilization test method in the disinfection technical Specification (2002 edition) of the Ministry of health, the sterilization rate of the antibacterial agent to staphylococcus aureus, escherichia coli and drug-resistant bacteria reaches 99.999 percent; the antiviral activity rate against enteroviruses, influenza viruses and novel coronaviruses was 99.3% as tested according to ASTM E2011-2009 (standard test methods for evaluating manual wash methods and hand rub formulations all for manual elimination of viral activity).
The using method comprises the following steps: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
Example 3
A foam-type low-carbon alcohol system hand disinfectant comprises, by weight, 65% of ethanol, 0.1% of isopropanol, 5% of bis-glucamide polydimethylsiloxane, 1.5% of glycerol, 0.1% of alkanolamide, 1% of didecyl methyl hydroxypropyl ammonium chloride and the balance of water.
The preparation method of the alcohol disinfectant comprises the steps of adding ethanol and isopropanol into a mixing tank, adding glycerol, didecylmethyl hydroxypropyl ammonium chloride and water, adding bis-glucosamide polydimethylsiloxane and alkanolamide into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant. The foam height was 305mm and 211mm for 3 minutes in time, as measured by a Roche foam tester according to GB/T7462. According to a quantitative sterilization test method in the disinfection technical Specification (2002 edition) of the Ministry of health, the sterilization rate of the antibacterial agent to staphylococcus aureus, escherichia coli and drug-resistant bacteria reaches 99.999 percent; the antiviral activity rate against enteroviruses, influenza viruses and novel coronaviruses was 99.5% as tested according to ASTM E2011-2009 (standard test methods for evaluating manual wash methods and hand rub formulations all for manual elimination of viral activity).
The using method comprises the following steps: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
Example 4
A foam-type low-carbon alcohol system hand disinfectant comprises, by weight, 40% of ethanol, 20% of isopropanol, 2% of glucamide polydimethylsiloxane, 2% of diglycerin, 3% of sodium polyacrylate, 0.8% of didecyl ammonium methyl formate and the balance of water.
The preparation method of the alcohol disinfectant comprises the steps of adding ethanol and isopropanol into a mixing tank, adding diglycerol, didecylmethyl ammonium formate and water, adding the bis-gluconamide polydimethylsiloxane and the gluconamide polydimethylsiloxane into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant. The foam height was 280mm in time and 170mm in 3 minutes as measured by a Roche foam apparatus according to GB/T7462. According to a quantitative sterilization test method in the disinfection technical Specification (2002 edition) of the Ministry of health, the sterilization rate of the antibacterial agent to staphylococcus aureus, escherichia coli and drug-resistant bacteria reaches 99.9 percent; the antiviral activity rate against enteroviruses, influenza viruses and novel coronaviruses reached 99.0% as tested by astm e2011-2009 (standard test methods for evaluating manual wash methods and hand rub formulations all for eliminating viral activity manually).
The using method comprises the following steps: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
The above examples are merely illustrative of several embodiments of the present invention, which are described in more detail and detail, but are not to be construed as limiting the scope of the invention. It should be noted that: it is within the ability of one of ordinary skill in the art to utilize the disclosed technology for various modifications and equivalent embodiments. According to the technical essence of the invention, simple modification, equivalent change and modification are carried out on the invention and all belong to the technical scheme of the invention.
Claims (7)
1. A foam type low-carbon alcohol system hand disinfectant is characterized in that: the composite material consists of the following raw materials in percentage by weight:
40-65% of ethanol, 0.1-20% of isopropanol, 0.1-5% of foaming agent, 0.01-3% of foam stabilizer, 0.5-2% of glycerol or diglycerol, 0.1-1% of bactericide and the balance of water.
2. The foam-type low-carbon alcohol system hand sanitizer according to claim 1, characterized in that: the foaming agent is an organic silicon type foaming agent.
3. The foam-type low-carbon alcohol system hand sanitizer according to claim 2, characterized in that: the foaming agent comprises one or more mixtures of PEG-n polydimethylsiloxane, bis-PEG-n polydimethylsiloxane, glucamide polydimethylsiloxane and bis-glucamide polydimethylsiloxane;
wherein PEG is polyoxyethylene ether, and the polymerization number n = 4-20.
4. The foam-type low-carbon alcohol system hand sanitizer according to claim 1, characterized in that: the foam stabilizer is one or a mixture of sodium polyacrylate and alkanolamide.
5. The foam-type low-carbon alcohol system hand sanitizer according to claim 1, characterized in that: the bactericide is one or a mixture of didecyl methyl hydroxyethyl ammonium chloride, didecyl methyl hydroxypropyl ammonium chloride, didecyl methyl ammonium formate, didecyl methyl hydroxyethyl ammonium acetate and (didodecyldimethyl) ethylene diammonium bromide.
6. A preparation method of the foam type low-carbon alcohol system hand disinfectant as claimed in any one of claims 1 to 5, characterized by comprising the following steps: firstly adding ethanol and isopropanol into a mixing tank, then adding glycerin or diglycerol, a bactericide and water, finally adding a foaming agent and a foam stabilizer into the mixing tank, and uniformly mixing to finish the preparation of the alcohol hand disinfectant.
7. The use method of the foam type low-carbon alcohol system hand disinfectant as claimed in any one of claims 1 to 5, is characterized in that: the alcohol hand disinfectant is smeared on the hands by a foam pump and kneaded for 30 s.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010341849.0A CN111449993A (en) | 2020-04-27 | 2020-04-27 | Foam type low-carbon alcohol system hand disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010341849.0A CN111449993A (en) | 2020-04-27 | 2020-04-27 | Foam type low-carbon alcohol system hand disinfectant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN111449993A true CN111449993A (en) | 2020-07-28 |
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| CN202010341849.0A Pending CN111449993A (en) | 2020-04-27 | 2020-04-27 | Foam type low-carbon alcohol system hand disinfectant and preparation method thereof |
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| CN (1) | CN111449993A (en) |
Citations (9)
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Application publication date: 20200728 |