CN111437288A - Atomized molecular iodine disinfectant and application thereof - Google Patents
Atomized molecular iodine disinfectant and application thereof Download PDFInfo
- Publication number
- CN111437288A CN111437288A CN202010431438.0A CN202010431438A CN111437288A CN 111437288 A CN111437288 A CN 111437288A CN 202010431438 A CN202010431438 A CN 202010431438A CN 111437288 A CN111437288 A CN 111437288A
- Authority
- CN
- China
- Prior art keywords
- iodide
- preparation
- molecular iodine
- atomized
- iodine disinfectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 239000000645 desinfectant Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 238000009472 formulation Methods 0.000 claims abstract description 18
- 230000001590 oxidative effect Effects 0.000 claims abstract description 18
- 238000000889 atomisation Methods 0.000 claims abstract description 16
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract description 16
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 14
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 14
- 239000011630 iodine Substances 0.000 claims abstract description 14
- 206010035148 Plague Diseases 0.000 claims abstract description 12
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 12
- 239000007800 oxidant agent Substances 0.000 claims abstract description 12
- 230000002378 acidificating effect Effects 0.000 claims abstract description 11
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 241001465754 Metazoa Species 0.000 claims abstract description 10
- 244000005700 microbiome Species 0.000 claims abstract description 10
- 230000001105 regulatory effect Effects 0.000 claims abstract description 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 24
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000005507 spraying Methods 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004327 boric acid Substances 0.000 claims description 6
- -1 iodide compound Chemical class 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 235000009518 sodium iodide Nutrition 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- 206010037742 Rabies Diseases 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 claims description 4
- 241000283073 Equus caballus Species 0.000 claims description 3
- 241000282898 Sus scrofa Species 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- XZXYQEHISUMZAT-UHFFFAOYSA-N 2-[(2-hydroxy-5-methylphenyl)methyl]-4-methylphenol Chemical compound CC1=CC=C(O)C(CC=2C(=CC=C(C)C=2)O)=C1 XZXYQEHISUMZAT-UHFFFAOYSA-N 0.000 claims description 2
- 208000030507 AIDS Diseases 0.000 claims description 2
- 208000007407 African swine fever Diseases 0.000 claims description 2
- 241000193738 Bacillus anthracis Species 0.000 claims description 2
- 206010006500 Brucellosis Diseases 0.000 claims description 2
- 206010069748 Burkholderia pseudomallei infection Diseases 0.000 claims description 2
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims description 2
- 208000012353 Contagious Pleuropneumonia Diseases 0.000 claims description 2
- 241000252233 Cyprinus carpio Species 0.000 claims description 2
- 208000001490 Dengue Diseases 0.000 claims description 2
- 206010012310 Dengue fever Diseases 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 241001115402 Ebolavirus Species 0.000 claims description 2
- 206010014096 Echinococciasis Diseases 0.000 claims description 2
- 208000009366 Echinococcosis Diseases 0.000 claims description 2
- 201000006353 Filariasis Diseases 0.000 claims description 2
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims description 2
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims description 2
- 208000002979 Influenza in Birds Diseases 0.000 claims description 2
- 206010024238 Leptospirosis Diseases 0.000 claims description 2
- 206010024641 Listeriosis Diseases 0.000 claims description 2
- 206010028470 Mycoplasma infections Diseases 0.000 claims description 2
- 208000010359 Newcastle Disease Diseases 0.000 claims description 2
- 208000026681 Paratuberculosis Diseases 0.000 claims description 2
- 208000007634 Peste-des-Petits-Ruminants Diseases 0.000 claims description 2
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010037688 Q fever Diseases 0.000 claims description 2
- 201000005485 Toxoplasmosis Diseases 0.000 claims description 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
- 241000700647 Variola virus Species 0.000 claims description 2
- 206010058874 Viraemia Diseases 0.000 claims description 2
- 241000710886 West Nile virus Species 0.000 claims description 2
- 201000007691 actinomycosis Diseases 0.000 claims description 2
- 229940107816 ammonium iodide Drugs 0.000 claims description 2
- 206010064097 avian influenza Diseases 0.000 claims description 2
- 208000003836 bluetongue Diseases 0.000 claims description 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims description 2
- 229910001640 calcium iodide Inorganic materials 0.000 claims description 2
- 229940046413 calcium iodide Drugs 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 201000005332 contagious pustular dermatitis Diseases 0.000 claims description 2
- 208000025729 dengue disease Diseases 0.000 claims description 2
- 208000006275 fascioliasis Diseases 0.000 claims description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims description 2
- BLQJIBCZHWBKSL-UHFFFAOYSA-L magnesium iodide Chemical compound [Mg+2].[I-].[I-] BLQJIBCZHWBKSL-UHFFFAOYSA-L 0.000 claims description 2
- 229910001641 magnesium iodide Inorganic materials 0.000 claims description 2
- QWYFOIJABGVEFP-UHFFFAOYSA-L manganese(ii) iodide Chemical compound [Mn+2].[I-].[I-] QWYFOIJABGVEFP-UHFFFAOYSA-L 0.000 claims description 2
- 201000004015 melioidosis Diseases 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 2
- 150000002978 peroxides Chemical class 0.000 claims description 2
- 208000009305 pseudorabies Diseases 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 208000006531 swine vesicular disease Diseases 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 18
- 239000007921 spray Substances 0.000 abstract description 7
- 241000251468 Actinopterygii Species 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract description 2
- 230000000816 effect on animals Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- 239000003570 air Substances 0.000 description 20
- 230000001954 sterilising effect Effects 0.000 description 14
- 238000002156 mixing Methods 0.000 description 13
- 241000700605 Viruses Species 0.000 description 9
- 244000052616 bacterial pathogen Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000001502 supplementing effect Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 5
- MLIWQXBKMZNZNF-KUHOPJCQSA-N (2e)-2,6-bis[(4-azidophenyl)methylidene]-4-methylcyclohexan-1-one Chemical compound O=C1\C(=C\C=2C=CC(=CC=2)N=[N+]=[N-])CC(C)CC1=CC1=CC=C(N=[N+]=[N-])C=C1 MLIWQXBKMZNZNF-KUHOPJCQSA-N 0.000 description 4
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 4
- 239000001230 potassium iodate Substances 0.000 description 4
- 235000006666 potassium iodate Nutrition 0.000 description 4
- 229940093930 potassium iodate Drugs 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001233242 Lontra Species 0.000 description 1
- 241000282342 Martes americana Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an atomized molecular iodine disinfectant and application thereof, wherein the disinfectant comprises a preparation 1 and a preparation 2; the formulation 1 includes iodide; the preparation 2 comprises an oxidant capable of oxidizing the iodide to generate iodine molecules, and an acidic pH regulator for regulating the mixture of the iodide and the oxidant to be acidic; the preparation 1 and the preparation 2 are separately packaged in two independent containers which are communicated with an atomization device together. The atomized molecular iodine disinfectant is applied to the medicines for treating plague and diseases caused by microorganisms. The iodine molecule spray preparation of the invention is more convenient to use, has wider application range when being applied, not only can be directly sprayed on human body or animal skin, but also can be used in indoor environment, and aquatic fishery including fish or other aquatic animals and plants, and has disinfection effect on animals and plants in the fields of livestock raising, agriculture and forestry, and the like and living environment thereof.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a molecular iodine disinfectant and application thereof.
Background
The current methods for treating influenza infection include isolation, washing hands, antiviral drugs, vaccination, and the like. Some sudden epidemic diseases are not well controlled by good specific drugs in sudden onset. The development of vaccines also requires a certain amount of time, and the epidemic viruses have a certain variability, so that the antiviral drugs and the vaccination do not play a great role in a certain time. Isolation is an effective means for epidemic viral infections, but effective isolation in confined spaces such as hospitals and crowded places is somewhat difficult, requiring a more effective way to protect the health and safety of the public.
Iodine is the most effective agent for killing viruses, particularly influenza viruses. Iodine is the most effective, low toxicity, broad spectrum fungicide. Iodine is commonly used as a germicidal preservative for various forms of skin, wound and mucous surfaces. And also to disinfect air and inanimate objects such as gut and surgical instruments. If the iodine can be sprayed while being isolated, the iodine is safer for patients, medical staff and all people engaged in public work.
Disclosure of Invention
The first technical problem to be solved by the invention is as follows: aiming at the defects in the prior art, the atomized molecular iodine disinfectant is provided, has good sterilizing effect and good stability, can be stored for a long time without reducing the sterilizing effect, and is more convenient to store and use.
The second technical problem to be solved by the invention is: aiming at the defects in the prior art, the application of the atomized molecular iodine disinfectant in the preparation of the medicines for treating plague and diseases caused by microorganisms is provided.
In order to solve the first technical problem, the technical scheme of the invention is as follows:
an atomized molecular iodine disinfectant formulation comprising formulation 1 and formulation 2; the formulation 1 includes iodide; the preparation 2 comprises an oxidant capable of oxidizing the iodide to generate iodine molecules, and an acidic pH regulator for regulating the mixture of the iodide and the oxidant to be acidic; the preparation 1 and the preparation 2 are separately packaged in two independent containers which are communicated with an atomization device together.
As an improved technical scheme, the preparation 1 and the preparation 2 are mixed in the atomization device and then atomized for use, or mixed and then used in the spraying process.
As a preferable technical solution, the iodide is an iodide compound capable of generating iodide anions in a solution, and the iodide compound is one or more of sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and zinc iodide.
Preferably, the oxidant is a substance capable of oxidizing the iodide to generate iodine molecules, and the oxidant is at least one of iodate, periodate and peroxide.
As a preferable technical scheme, the acidic pH regulator is one or more of phosphoric acid, citric acid, tartaric acid, salicylic acid, malic acid and boric acid.
Preferably, the atomization device comprises a compression atomizer, a pressure sprayer or a pressure spray bottle.
Specifically, a humidifier, a high-pressure sprayer, a small household watering can, an atomizer, a spray bottle, a sprayer, or the like, which can spray or atomize the liquid preparation in the environment can be preferably used.
In order to solve the second technical problem, the technical solution of the present invention is:
the atomized molecular iodine disinfectant is applied to the medicines for treating plague and diseases caused by microorganisms.
As a further improved technical scheme, the atomized molecular iodine disinfectant is applied to medicines for treating human black-and-dead-man disease, plague, smallpox, influenza, rabies, tuberculosis, dengue fever, AIDS, West Nile virus and Ebola virus.
As a further improved technical scheme, the atomized molecular iodine disinfectant is applied to medicaments for treating animal foot-and-mouth disease, swine vesicular disease, swine plague, African swine fever, highly pathogenic porcine reproductive and respiratory syndrome, African horse plague, cattle plague, bovine contagious pleuropneumonia, bovine spongiform encephalopathy, itch disease, blue tongue disease, peste des petits ruminants, sheep pox, goatpox, highly pathogenic avian influenza, new castle disease, carp spring viremia, white spot syndrome, rabies, brucellosis, anthrax, pseudorabies, Clostridium welchii disease, paratuberculosis, toxoplasmosis, echinococcosis, leptospirosis, colibacillosis, listeriosis, melioidosis, actinomycosis, fascioliasis, filariasis, eperythrozoonosis and Q fever.
As a further improved technical scheme, the atomized molecular iodine disinfectant is applied to medicines for treating plague and diseases of aquatic animals caused by microorganisms.
As a further improvement, the atomized molecular iodine disinfectant formulation can also be used for treating livestock and poultry such as: the application of the medicine in the medicines of chicken, duck, goose, bird, pigeon, quail, cattle, sheep, pig, horse, donkey, mule, camel, deer, marten, otter, musk and the like.
Due to the adoption of the technical scheme, the invention has the beneficial effects that:
the atomized molecular iodine disinfectant preparation comprises a preparation 1 and a preparation 2; the formulation 1 includes iodide; the preparation 2 comprises an oxidant capable of oxidizing the iodide to generate iodine molecules, and an acidic pH regulator for regulating the mixture of the iodide and the oxidant to be acidic; the preparation 1 and the preparation 2 are separately packaged in two independent containers which are communicated with an atomization device together. The preparation of the invention is used after being sprayed by an atomizing device, and has the characteristic of more excellent and convenient use compared with liquid solid preparations. When in use, only spraying is needed, and a sterilization and disinfection environment with controllable concentration can be formed in the air. Iodine sprays can be used as a practical means of controlling indoor infections during epidemics such as influenza. Can also be used as a barrier for resisting bacteria of human skin. Airborne viruses that cause influenza can be killed at low concentrations. Iodine has no toxicity, almost has no side effect except high dose, and can also play a certain role in resisting bacteria and viruses in or on the human body through the respiratory system, the digestive system, the skin of the human body and the like.
The spray preparation of the invention is more convenient to use, has wider application range when being applied, not only can be directly sprayed on the skin of human bodies or animals, but also can be used in indoor environment, and aquatic fishery including fishes or other aquatic animals and plants. Has the function of disinfection for animals, plants and living environment in the fields of animal husbandry, agriculture and forestry and the like.
Detailed Description
The invention is further illustrated below with reference to specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1
Dissolving 1g of sodium iodide in water at normal temperature, adding 10g of glycerol, and adding 89g of water to obtain a solution 1 after completely mixing and dissolving. Dissolving 0.3g of potassium periodate in water at normal temperature, adding 3.5g of acid pH regulator phosphoric acid, supplementing 96.2g of water, and mixing and dissolving completely to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 (namely 1g of solution 1 and 1g of solution 2) are mixed and sprayed for use, disinfection and sterilization are carried out, and the sterilization components are atomized into the air or the environment by virtue of atomization to kill germs in the air and the environment.
Example 2
Dissolving 2g of potassium iodide in water at normal temperature, adding 5g of pentanediol, adding 1g of octanediol, complementing the water to 92g, and mixing and dissolving completely to obtain a solution 1. Dissolving 0.5g of potassium iodate in water at normal temperature, adding 3.5g of acid pH regulator malic acid, adding 96g of water, and mixing and dissolving completely to obtain solution 2.
The solution 1 and the solution 2 are separately arranged in two independent containers and are sprayed for use simultaneously, and the solution 1 and the solution 2 are sprayed out from the nozzles, so that the solution 1 and the solution 2 can contact at the moment of spraying, and the free iodine of the bactericidal active ingredient can be instantly generated, the bactericidal ingredient is atomized into the air or the environment, and germs in the air and the environment are killed.
Example 3
Dissolving 2g of sodium iodide and 10g of potassium iodide in 88g of water at normal temperature, and mixing and completely dissolving to obtain a solution 1. Dissolving 3g of potassium iodate in water at normal temperature, adding 5g of boric acid and 2g of propylene glycol, supplementing 90g of water, and mixing and dissolving completely to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 mixing, adding water to dissolve, spraying (i.e. 1g of solution 1 and 1g of solution 2 are dissolved in 50 g of water), sterilizing, atomizing the sterilizing components into air or environment by atomization, and killing germs in the air and environment.
Example 4
Dissolving 0.1g of potassium iodide into a small amount of water, adding 10g of glycerol, supplementing 89.9g of water, and uniformly stirring to obtain a solution 1. Dissolving 0.1g of potassium periodate with a small amount of water, dissolving 10g of pentanediol, 2g of tartaric acid and 87.9g of complementary water, and uniformly stirring to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 (namely 1g of solution 1 and 1g of solution 2) are mixed and sprayed for use, disinfection and sterilization are carried out, and the sterilization components are atomized into the air or the environment by virtue of atomization to kill germs in the air and the environment.
Example 5
Dissolving 2g of potassium iodide into a small amount of water, adding 3g of boric acid, supplementing 95g of water, and uniformly stirring to obtain a solution 1. Dissolving 0.5g of potassium periodate with a small amount of water, dissolving 5g of pentanediol, 0.5g of tartaric acid and 94g of complementary water, and uniformly stirring to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 (namely 1g of solution 1 and 1g of solution 2) are mixed and sprayed for use, disinfection and sterilization are carried out, and the sterilization components are atomized into the air or the environment by virtue of atomization to kill germs in the air and the environment.
Example 6
Dissolving 5g of sodium iodide in water at normal temperature, adding 10g of boric acid and 5g of pentanediol, complementing the water to 80g, and mixing and dissolving completely to obtain a solution 1. Dissolving 4g of potassium iodate in water at normal temperature, adding 2g of acid pH regulator malic acid, supplementing 94g of water, and mixing and dissolving completely to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 (namely 1g of solution 1 and 1g of solution 2) are mixed and sprayed for use, disinfection and sterilization are carried out, and the sterilization components are atomized into the air or the environment by virtue of atomization to kill germs in the air and the environment.
Example 7
Dissolving 8g of potassium iodide in water at normal temperature, adding 92g of water, and mixing and dissolving completely to obtain a solution 1. Dissolving 4g of potassium iodate in water at normal temperature, adding 5g of an acidic pH regulator citric acid, supplementing 91g of water, and mixing and dissolving completely to obtain a solution 2.
The solution 1 and the solution 2 are separately packaged in two independent containers according to the proportion of 1 to 2: 1 (namely 1g of solution 1 and 1g of solution 2) are mixed and sprayed for use, disinfection and sterilization are carried out, and the sterilization components are atomized into the air or the environment by virtue of atomization to kill germs in the air and the environment.
Example 8
The disinfectant prepared according to the previous example was used as a test fluid. Test the killing effect of molecular iodine on pathogenic microorganisms in the environment.
Pouring the disinfectant into atomization equipment, and keeping the air humidity at 95% -100% by the atomization equipment, wherein the dosage of the mixed liquid of the molecular iodine spray contained in the atomized liquid maintaining the environmental humidity of 1 cubic meter is 22ml, and keeping the humidity for 30 min. And then sampling according to a liquid impact type sampler, testing, and culturing microorganisms to obtain the result that the germ killing rate is not less than 90%. The method has certain effect of killing microorganisms in the air.
Example 9
The molecular iodine solution prepared in the example 7 is put into a spraying device, and is uniformly sprayed on the surface of an object (comprising the ground, a door handle, a stainless steel table top and a scalpel), and after at least 10min of action, microorganisms on the surface of the object are sampled and tested. And the bactericidal rate is greater than or equal to 90 percent compared with the blank control group.
Example 10
Dissolving 1g of potassium iodide into a small amount of water, adding 3g of boric acid, supplementing 96g of water, and uniformly stirring to obtain a solution 1. Dissolving 0.5g of potassium periodate with a small amount of water, dissolving 5g of pentanediol, 0.5g of citric acid and 94g of complementary water, and uniformly stirring to obtain a solution 2. And mixing the solution 1 and the solution 2 according to the equal amount to obtain the test solution. The following is a test experiment of viruses in the air after the test solution was atomized by the atomizer.
Remarking: at 1.5m3And (3) in a closed experiment chamber, collecting air as initial virus concentration after spraying viruses for 15min, then uniformly mixing and atomizing sample liquids No. 1 and No. 2 for 30m L, testing the sample liquids in the experiment chamber for 60min, 120min and 180min, and spraying the viruses for 5min respectively at 30min, 90min and 150min in the testing process.
And (4) conclusion: the atomized molecular iodine has good effect of killing virus and microorganism in the ambient air.
Claims (10)
1. An atomized molecular iodine disinfectant formulation characterized by: the disinfectant preparation comprises a preparation 1 and a preparation 2; the formulation 1 includes iodide; the preparation 2 comprises an oxidant capable of oxidizing the iodide to generate iodine molecules, and an acidic pH regulator for regulating the mixture of the iodide and the oxidant to be acidic; the preparation 1 and the preparation 2 are separately packaged in two independent containers which are communicated with an atomization device together.
2. The aerosolized molecular iodine disinfectant formulation according to claim 1, wherein: the preparation 1 and the preparation 2 are mixed in the atomization device and then atomized for use, or mixed in the spraying process and then used.
3. The aerosolized molecular iodine disinfectant formulation according to claim 1, wherein: the iodide is an iodide compound capable of generating iodide anions in a solution, and the iodide compound is one or more of sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and zinc iodide.
4. The aerosolized molecular iodine disinfectant formulation according to claim 1, wherein: the oxidant is a substance capable of oxidizing the iodide to generate iodine molecules, and the oxidant is at least one of iodate, periodate and peroxide.
5. The aerosolized molecular iodine disinfectant formulation according to claim 1, wherein: the acidic pH regulator is one or more of phosphoric acid, citric acid, tartaric acid, salicylic acid, malic acid and boric acid.
6. The aerosolized molecular iodine disinfectant formulation according to claim 1, wherein: the atomization device comprises a compression type atomizer, a pressure atomizer or a pressure atomizing bottle.
7. Use of an atomized molecular iodine disinfectant formulation as claimed in any one of claims 1 to 6 in the preparation of a medicament for treating plague and diseases caused by microorganisms.
8. Use of an aerosolized molecular iodine disinfectant formulation according to claim 7 wherein: the atomized molecular iodine disinfectant can be used in medicines for treating human black-dead-man disease, plague, smallpox, influenza, rabies, tuberculosis, dengue fever, AIDS, West Nile virus and Ebola virus.
9. Use of an aerosolized molecular iodine disinfectant formulation according to claim 7 wherein: the atomized molecular iodine disinfectant is applied to the medicines for treating animal foot-and-mouth disease, swine vesicular disease, swine fever, African swine fever, high-pathogenicity porcine reproductive and respiratory syndrome, African horse fever, cattle plague, bovine contagious pleuropneumonia, bovine spongiform encephalopathy, itch, bluetongue disease, peste des petits ruminants, sheep pox, goat pox, high-pathogenicity avian influenza, Newcastle disease, spring carp viremia, white spot syndrome, rabies, brucellosis, anthrax, pseudorabies, Clostridium welchii disease, paratuberculosis, toxoplasmosis, echinococcosis, leptospirosis, colibacillosis, listeriosis, melioidosis, actinomycosis, fascioliasis, filariasis, eperythrozoonosis and Q fever.
10. Use of an aerosolized molecular iodine disinfectant formulation according to claim 7 wherein: the atomized molecular iodine disinfectant is applied to the medicines for treating plague and diseases of aquatic animals caused by microorganisms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010431438.0A CN111437288A (en) | 2020-05-20 | 2020-05-20 | Atomized molecular iodine disinfectant and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010431438.0A CN111437288A (en) | 2020-05-20 | 2020-05-20 | Atomized molecular iodine disinfectant and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111437288A true CN111437288A (en) | 2020-07-24 |
Family
ID=71655448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010431438.0A Pending CN111437288A (en) | 2020-05-20 | 2020-05-20 | Atomized molecular iodine disinfectant and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111437288A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791097A (en) * | 2020-11-27 | 2021-05-14 | 金玉东 | Application of iodine in preparing medicament for preventing and treating respiratory infectious diseases and method for preparing low-particle-size iodine-containing aerosol |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670648A (en) * | 2012-06-07 | 2012-09-19 | 维尔信科技（潍坊）有限公司 | Liquid iodine disinfectant, preparation method and used container thereof |
| CN102688257A (en) * | 2012-06-07 | 2012-09-26 | 维尔信科技（潍坊）有限公司 | Liquid molecular iodine disinfectant, preparation method and used container |
-
2020
- 2020-05-20 CN CN202010431438.0A patent/CN111437288A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670648A (en) * | 2012-06-07 | 2012-09-19 | 维尔信科技（潍坊）有限公司 | Liquid iodine disinfectant, preparation method and used container thereof |
| CN102688257A (en) * | 2012-06-07 | 2012-09-26 | 维尔信科技（潍坊）有限公司 | Liquid molecular iodine disinfectant, preparation method and used container |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791097A (en) * | 2020-11-27 | 2021-05-14 | 金玉东 | Application of iodine in preparing medicament for preventing and treating respiratory infectious diseases and method for preparing low-particle-size iodine-containing aerosol |
| WO2022111497A1 (en) * | 2020-11-27 | 2022-06-02 | 金玉东 | Application of iodine in preparation of drugs for preventing and treating respiratory tract infectious diseases |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109646361B (en) | Composite biological deodorization spray for pets and preparation method thereof | |
| US20220257642A1 (en) | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract | |
| US20220370493A1 (en) | Methods and compositions for generating nitric oxide and uses thereof | |
| JP2005531637A (en) | Disinfecting composition | |
| CN111249173B (en) | Deodorizing and purifying concentrated solution and preparation method and application thereof | |
| US20240016831A1 (en) | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 | |
| TWI619519B (en) | Volatile disinfectant and method for manufacturing volatile disinfectant | |
| CA3190747A1 (en) | Methods and uses of producing compositions stably comprising free available chlorine species and peroxides | |
| CN111437288A (en) | Atomized molecular iodine disinfectant and application thereof | |
| EA025666B1 (en) | Powder composition for disinfection of the teats of dairy animals | |
| US20060075922A1 (en) | Controlled-acidity composition | |
| JPH07502518A (en) | wound disinfectant | |
| KR20230145023A (en) | Compositions and methods for disinfecting, treating and preventing microbial infections | |
| CN101132778B (en) | Composition for regulating water quality of water used for administering drugs or vaccines sensitive to water disinfectants | |
| RU2097030C1 (en) | Preparation for aerosol use for control over respiratory illnesses in animals and birds | |
| CN107753937A (en) | A kind of wound disinfection agent and preparation method thereof | |
| RU2063231C1 (en) | Preparation for aerosol therapy and prophylaxis against respiratory disease in animals | |
| RU2854201C1 (en) | Disinfectant with repellent properties | |
| RU2075974C1 (en) | Preparation for aerosol treatment and prophylaxis of respiratory sickness in animals | |
| CN117837593A (en) | Disinfectant for body surfaces and houses of livestock and poultry | |
| CN1097452C (en) | Skin spraying sterilizing agent | |
| RU2107501C1 (en) | Iodotriethylene glycol, veterinary preparation for treatment of infectious diseases in poultry | |
| AU2023375559A1 (en) | Compositions comprising stable free available chlorine species and peroxides, methods of making and uses thereof | |
| KR20250100231A (en) | Insect repellent composition and method for repelling insect | |
| RU2123355C1 (en) | Disinfection agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200724 |