[go: up one dir, main page]

CN111297342A - Heart rhythm measuring method based on egg embryo blood flow information - Google Patents

Heart rhythm measuring method based on egg embryo blood flow information Download PDF

Info

Publication number
CN111297342A
CN111297342A CN201911145896.1A CN201911145896A CN111297342A CN 111297342 A CN111297342 A CN 111297342A CN 201911145896 A CN201911145896 A CN 201911145896A CN 111297342 A CN111297342 A CN 111297342A
Authority
CN
China
Prior art keywords
information
blood flow
position line
heart rhythm
phase information
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911145896.1A
Other languages
Chinese (zh)
Inventor
曾亚光
岑颖珊
韩定安
王茗祎
黎思娜
冯俊键
曾锟
张章
杨旭伦
伍海龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Foshan University
Original Assignee
Foshan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foshan University filed Critical Foshan University
Priority to CN201911145896.1A priority Critical patent/CN111297342A/en
Publication of CN111297342A publication Critical patent/CN111297342A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024Measuring pulse rate or heart rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026Measuring blood flow
    • A61B5/0261Measuring blood flow using optical means, e.g. infrared light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7253Details of waveform analysis characterised by using transforms
    • A61B5/7257Details of waveform analysis characterised by using transforms using Fourier transforms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40Animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Mathematical Physics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

本发明公开了一种基于鸡蛋胚胎血流信息的心律测量方法,该方法基于OCT扫描系统,包括:步骤1、将扫描区域横向等分为多个位置线区间;步骤2、通过OCT扫描系统扫描位置线区间,得到在扫描区域中血流在不同的位置线区间上的速度信息;步骤3、对所述速度信息进行傅里叶谱变换得到频率‑加速度关系曲线,根据频率‑加速度关系曲线得到心律。通过OCT扫描系统对于扫描区域进行有深度的扫描,而且,可以利用鸡蛋胚胎大动脉的血流信息从侧面上得到鸡蛋胚胎的心律。相对于现有技术,该方法得到的心律信息更加完整和准确。本发明主要用于鸡蛋胚胎的研究工作中。

Figure 201911145896

The invention discloses a heart rhythm measurement method based on egg embryo blood flow information. The method is based on an OCT scanning system, comprising: step 1, dividing the scanning area horizontally into multiple position line intervals; step 2, scanning through the OCT scanning system Position line interval, obtain the speed information of blood flow on different position line intervals in the scanning area; Step 3, perform Fourier spectrum transformation on the speed information to obtain the frequency-acceleration relationship curve, obtain according to the frequency-acceleration relationship curve heart rate. The scanning area is deeply scanned by the OCT scanning system, and the heart rhythm of the egg embryo can be obtained from the side by using the blood flow information of the aorta of the egg embryo. Compared with the prior art, the heart rhythm information obtained by this method is more complete and accurate. The invention is mainly used in the research work of egg embryo.

Figure 201911145896

Description

一种基于鸡蛋胚胎血流信息的心律测量方法A method for measuring heart rhythm based on egg embryo blood flow information

技术领域technical field

本发明涉及光学成像技术领域,特别涉及一种基于鸡蛋胚胎血流信息的心律测量方法。The invention relates to the technical field of optical imaging, in particular to a heart rhythm measurement method based on egg embryo blood flow information.

背景技术Background technique

心脏的发育情况及周边血流的流动情况都会对动物的后续发育,包括组织及形体上的生长造成影响。光学相干层析成像技术(OCT)是20世纪90年代逐步发展而成的一种新的三维层析成像技术,通常使用宽带光源来实现低相干干涉,从而获得较高的分辨率,一般在10μm左右。目前OCT在心血管系统方面的应用有将光谱OCT成像技术与多普勒技术相结合来检测高度散射生物组织的血流速度,并同时进行组织结构成像,常用于亚表层微血管直径和血流速度分布的测量。The development of the heart and the flow of peripheral blood flow will affect the subsequent development of the animal, including tissue and physical growth. Optical coherence tomography (OCT) is a new three-dimensional tomography technology gradually developed in the 1990s. It usually uses a broadband light source to achieve low coherence interference, so as to obtain higher resolution, generally 10μm. about. At present, the application of OCT in the cardiovascular system includes the combination of spectral OCT imaging technology and Doppler technology to detect the blood flow velocity of highly scattered biological tissues, and to perform tissue structure imaging at the same time. It is often used for subsurface microvessel diameter and blood flow velocity distribution. Measurement.

现有的对鸡蛋胚胎进行心律测量的方法是通过直接采集待测鸡蛋胚胎心脏区域的图像,The existing method for measuring the heart rhythm of egg embryos is to directly acquire the image of the heart region of the egg embryo to be tested,

利用激光散斑原理以动态信号和静态信号之比作为成像参量得出心律曲线图,再计算一分钟内所述心律曲线图上周期的个数,得到待测鸡蛋胚胎的心律值。该方法需要作用在鸡蛋胚胎的心脏部位,十分不方便。Using the laser speckle principle, the ratio of the dynamic signal and the static signal is used as the imaging parameter to obtain the heart rhythm graph, and then the number of cycles on the heart rhythm graph in one minute is calculated to obtain the heart rhythm value of the egg embryo to be tested. This method needs to act on the heart of the egg embryo, which is very inconvenient.

发明内容SUMMARY OF THE INVENTION

本发明的目的是提供一种基于鸡蛋胚胎血流信息的心律测量方法,以解决现有技术中所存在的一个或多个技术问题,至少提供一种有益的选择或创造条件。The purpose of the present invention is to provide a heart rhythm measurement method based on egg embryo blood flow information, so as to solve one or more technical problems existing in the prior art, and at least provide a beneficial choice or create conditions.

本发明解决其技术问题的解决方案是:一种基于鸡蛋胚胎血流信息的心律测量方法,该方法基于OCT扫描系统,包括:The solution of the present invention to solve the technical problem is: a method for measuring heart rhythm based on blood flow information of egg embryos, the method is based on an OCT scanning system, and includes:

步骤1、将扫描区域横向等分为多个位置线区间;Step 1. Divide the scanning area horizontally into multiple position line intervals;

步骤2、通过OCT扫描系统扫描位置线区间,得到在扫描区域中血流在不同的位置线区间上的速度信息;Step 2. Scan the position line interval by the OCT scanning system, and obtain the velocity information of blood flow on different position line intervals in the scanning area;

步骤3、对所述速度信息进行傅里叶谱变换得到频率-加速度关系曲线,根据频率-加速度关系曲线得到心律。Step 3: Perform Fourier spectral transformation on the speed information to obtain a frequency-acceleration relationship curve, and obtain a heart rhythm according to the frequency-acceleration relationship curve.

进一步,步骤2的子步骤包括:Further, the sub-steps of step 2 include:

步骤2.1、通过OCT扫描系统对位置线区间进行两次截面扫描,得到第一截面图和第二截面图;Step 2.1, perform two cross-sectional scans on the position line interval through the OCT scanning system to obtain the first cross-sectional view and the second cross-sectional view;

步骤2.2、对第一截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第一相位信息;对第二截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第二相位信息;Step 2.2: Perform non-node boundary cubic spline interpolation processing on the first cross-sectional image, and then perform Fourier transform to obtain phase information, which is recorded as the first phase information; perform non-node boundary cubic spline sampling on the second cross-sectional image. After the strip interpolation processing, Fourier transform is performed to obtain phase information, and the phase information is denoted as second phase information;

步骤2.3、根据速度模型得到血流在所述位置线区间的速度信息;Step 2.3, obtaining the velocity information of the blood flow in the position line interval according to the velocity model;

步骤2.4、重复步骤2.1至步骤2.3直至得到所有位置线区间的速度信息;Step 2.4, repeat steps 2.1 to 2.3 until the speed information of all position line intervals is obtained;

其中,所述速度模型为:Wherein, the speed model is:

Figure BDA0002282186250000021
Figure BDA0002282186250000021

v表示为速度信息,λ表示为OCT扫描系统中检测光的波长,Φ1表示为第一相位信息,Φ2表示为第二相位信息,i表示为复审虚部的符号,Im表示为提取复审的虚部,Re表示为提取复数的实部。v is the velocity information, λ is the wavelength of the detected light in the OCT scanning system, Φ 1 is the first phase information, Φ 2 is the second phase information, i is the symbol of the imaginary part of the review, Im is the extraction review The imaginary part of , Re is denoted to extract the real part of the complex number.

进一步,所述扫描区域的尺寸为2.5mm*2.5mm。Further, the size of the scanning area is 2.5mm*2.5mm.

本发明的有益效果是:通过OCT扫描系统对于扫描区域进行有深度的扫描,而且,可以利用鸡蛋胚胎大动脉的血流信息从侧面上得到鸡蛋胚胎的心律。相对于现有技术,该方法得到的心律信息更加完整和准确。The beneficial effect of the present invention is that the scanning area is deeply scanned by the OCT scanning system, and the heart rhythm of the egg embryo can be obtained from the side by using the blood flow information of the aorta of the egg embryo. Compared with the prior art, the heart rhythm information obtained by this method is more complete and accurate.

附图说明Description of drawings

为了更清楚地说明本发明实施例中的技术方案,下面将对实施例描述中所需要使用的附图作简单说明。显然,所描述的附图只是本发明的一部分实施例,而不是全部实施例,本领域的技术人员在不付出创造性劳动的前提下,还可以根据这些附图获得其他设计方案和附图。In order to illustrate the technical solutions in the embodiments of the present invention more clearly, the following briefly describes the accompanying drawings that are used in the description of the embodiments. Obviously, the described drawings are only a part of the embodiments of the present invention, but not all of the embodiments, and those skilled in the art can obtain other design solutions and drawings according to these drawings without creative work.

图1是基于鸡蛋胚胎血流信息的心律测量方法的步骤流程图;Fig. 1 is the step flow chart of the heart rhythm measurement method based on egg embryo blood flow information;

图2是步骤2的子步骤流程图。FIG. 2 is a flow chart of the sub-steps of step 2. FIG.

具体实施方式Detailed ways

以下将结合实施例和附图对本发明的构思、具体结构及产生的技术效果进行清楚、完整地描述,以充分地理解本发明的目的、特征和效果。显然,所描述的实施例只是本发明的一部分实施例,而不是全部实施例,基于本发明的实施例,本领域的技术人员在不付出创造性劳动的前提下所获得的其他实施例,均属于本发明保护的范围。另外,文中所提到的所有联接/连接关系,并非单指构件直接相接,而是指可根据具体实施情况,通过添加或减少联接辅件,来组成更优的联接结构。本发明创造中的各个技术特征,在不互相矛盾冲突的前提下可以交互组合。The concept, specific structure and technical effects of the present invention will be clearly and completely described below with reference to the embodiments and accompanying drawings, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative efforts are all within the scope of The scope of protection of the present invention. In addition, all the coupling/connection relationships mentioned in the text do not mean that the components are directly connected, but refer to a better coupling structure by adding or reducing coupling accessories according to specific implementation conditions. Various technical features in the present invention can be combined interactively on the premise of not contradicting each other.

参考图1和图2,一种基于鸡蛋胚胎血流信息的心律测量方法,该方法基于OCT扫描系统,包括:Referring to Figure 1 and Figure 2, a method for measuring heart rhythm based on egg embryo blood flow information, the method is based on an OCT scanning system, including:

步骤1、将扫描区域横向等分为多个位置线区间;Step 1. Divide the scanning area horizontally into multiple position line intervals;

步骤2、通过OCT扫描系统扫描位置线区间,得到在扫描区域中血流在不同的位置线区间上的速度信息;Step 2. Scan the position line interval by the OCT scanning system, and obtain the velocity information of blood flow on different position line intervals in the scanning area;

步骤3、对所述速度信息进行傅里叶谱变换得到频率-加速度关系曲线,根据频率-加速度关系曲线得到心律。Step 3: Perform Fourier spectral transformation on the speed information to obtain a frequency-acceleration relationship curve, and obtain a heart rhythm according to the frequency-acceleration relationship curve.

步骤2的子步骤包括:The sub-steps of step 2 include:

步骤2.1、通过OCT扫描系统对位置线区间进行两次截面扫描,得到第一截面图和第二截面图;Step 2.1, perform two cross-sectional scans on the position line interval through the OCT scanning system to obtain the first cross-sectional view and the second cross-sectional view;

步骤2.2、对第一截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第一相位信息;对第二截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第二相位信息;Step 2.2: Perform non-node boundary cubic spline interpolation processing on the first cross-sectional image, and then perform Fourier transform to obtain phase information, which is recorded as the first phase information; perform non-node boundary cubic spline sampling on the second cross-sectional image. After the strip interpolation processing, Fourier transform is performed to obtain phase information, and the phase information is denoted as second phase information;

步骤2.3、根据速度模型得到血流在所述位置线区间的速度信息;Step 2.3, obtaining the velocity information of the blood flow in the position line interval according to the velocity model;

步骤2.4、重复步骤2.1至步骤2.3直至得到所有位置线区间的速度信息;Step 2.4, repeat steps 2.1 to 2.3 until the speed information of all position line intervals is obtained;

其中,所述速度模型为:Wherein, the speed model is:

Figure BDA0002282186250000041
Figure BDA0002282186250000041

v表示为速度信息,λ表示为OCT扫描系统中检测光的波长,Φ1表示为第一相位信息,Φ2表示为第二相位信息,i表示为复审虚部的符号,Im表示为提取复审的虚部,Re表示为提取复数的实部。v is the velocity information, λ is the wavelength of the detected light in the OCT scanning system, Φ 1 is the first phase information, Φ 2 is the second phase information, i is the symbol of the imaginary part of the review, Im is the extraction review The imaginary part of , Re is denoted to extract the real part of the complex number.

具体的,需要对鸡蛋胚胎的心律进行测量时,通过将扫描区域划定为鸡蛋胚胎大动脉血管所在区域。其中,所述扫描区域的尺寸为2.5mm*2.5mm。先将扫描区域横向划分为多个位置线区间,在本实施例中,则划分为50个位置线区间。然后控制OCT扫描系统对扫描区域进行扫描,其中,扫描的方式为:对每一个位置线区间都扫描两次,每一次扫描均可以得到所在位置线区间的截面图。以对于一个位置线区间为例,第一次扫描得到第一截面图,第二次扫描得到第二截面图。对于OCT扫描系统来讲,得到的截面图中采集的干涉光的光强I为:

Figure BDA0002282186250000051
上述公式记为公式(1),其中,S表示为OCT扫描系统中检测光出光时的光强;Rl与Rr分别表示样品臂和参考臂的光程;k为波矢,k=2π/λ,λ表示为OCT扫描系统中检测光的波长;zl表示为扫描的深度,vl分别表示为扫描位置的血流速度。从公式(1)可以知道截面图中记录了血流速度的信息。Specifically, when the heart rhythm of the egg embryo needs to be measured, the scanning area is defined as the area where the aorta of the egg embryo is located. Wherein, the size of the scanning area is 2.5mm*2.5mm. First, the scanning area is horizontally divided into a plurality of position line sections, and in this embodiment, it is divided into 50 position line sections. Then, the OCT scanning system is controlled to scan the scanning area. The scanning method is as follows: each position line interval is scanned twice, and a cross-sectional view of the position line interval can be obtained in each scan. Taking a position line interval as an example, a first cross-sectional view is obtained by the first scan, and a second cross-sectional view is obtained by the second scan. For the OCT scanning system, the light intensity I of the interference light collected in the obtained cross-sectional view is:
Figure BDA0002282186250000051
The above formula is recorded as formula (1), where S represents the light intensity of the detected light in the OCT scanning system when the light is emitted; R l and R r represent the optical path of the sample arm and the reference arm respectively; k is the wave vector, k=2π /λ, λ represents the wavelength of the detected light in the OCT scanning system; z l represents the scanning depth, and v l represents the blood flow velocity at the scanning position, respectively. From the formula (1), it can be known that the information of the blood flow velocity is recorded in the cross-sectional view.

对于第一截面图和第二截面图分别进行非节点边界三次样条插值处理,其中,非节点边界三次样条插值处理可以对输入图像进行频域分析,得到频域信息和相位信息。故,对第一截面图进行非节点边界三次样条插值处理得到第一截面图的频域信息和相位信息。其中,频域信息对于本实施例没有作用,故舍弃,得到相位信息,记为第一相位信息。同理,对第二截面图进行非节点边界三次样条插值处理得到第二截面图的相位信息,记为第二相位信息。由于血流在流动,因此,第一相位信息和第二相位信息可以反应出血流的流动情况。因此,通过速度模型得到所在位置线区间的速度信息。重复上述操作,直至得到所有位置线区域的速度信息。并对得到的速度信息进行傅里叶谱变换得到频率-加速度关系曲线,根据频率-加速度关系曲线得到心律。由于鸡蛋胚胎的心脏在整个鸡蛋胚胎中处于血流中心位置,因此,扫描区域的各个位置线区域的加速度信息的整体可以反映出鸡蛋胚胎的心律信息。Non-node boundary cubic spline interpolation processing is performed on the first cross-sectional image and the second cross-sectional image respectively, wherein the non-node boundary cubic spline interpolation processing can perform frequency domain analysis on the input image to obtain frequency domain information and phase information. Therefore, the non-node boundary cubic spline interpolation processing is performed on the first cross-sectional view to obtain frequency domain information and phase information of the first cross-sectional view. The frequency domain information has no effect on this embodiment, so it is discarded to obtain phase information, which is recorded as the first phase information. Similarly, non-node boundary cubic spline interpolation processing is performed on the second cross-sectional view to obtain phase information of the second cross-sectional view, which is recorded as second phase information. Since the blood is flowing, the first phase information and the second phase information can reflect the flow of the blood. Therefore, the speed information of the position line section is obtained through the speed model. Repeat the above operation until the speed information of all position line areas is obtained. The obtained velocity information is subjected to Fourier transform to obtain a frequency-acceleration relationship curve, and the heart rhythm is obtained according to the frequency-acceleration relationship curve. Since the heart of the egg embryo is at the center of blood flow in the whole egg embryo, the whole of the acceleration information of each position line area in the scanning area can reflect the heart rhythm information of the egg embryo.

以上对本发明的较佳实施方式进行了具体说明,但本发明创造并不限于所述实施例,熟悉本领域的技术人员在不违背本发明精神的前提下还可做出种种的等同变型或替换,这些等同的变型或替换均包含在本申请权利要求所限定的范围内。The preferred embodiments of the present invention have been specifically described above, but the present invention is not limited to the embodiments, and those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention , these equivalent modifications or substitutions are all included within the scope defined by the claims of the present application.

Claims (3)

1.一种基于鸡蛋胚胎血流信息的心律测量方法,该方法基于OCT扫描系统,其特征在于:包括:1. a heart rhythm measurement method based on egg embryo blood flow information, the method is based on OCT scanning system, it is characterized in that: comprise: 步骤1、将扫描区域横向等分为多个位置线区间;Step 1. Divide the scanning area horizontally into multiple position line intervals; 步骤2、通过OCT扫描系统扫描位置线区间,得到在扫描区域中血流在不同的位置线区间上的速度信息;Step 2. Scan the position line interval by the OCT scanning system, and obtain the velocity information of blood flow on different position line intervals in the scanning area; 步骤3、对所述速度信息进行傅里叶谱变换得到频率-加速度关系曲线,根据频率-加速度关系曲线得到心律。Step 3: Perform Fourier spectral transformation on the speed information to obtain a frequency-acceleration relationship curve, and obtain a heart rhythm according to the frequency-acceleration relationship curve. 2.根据权利要求1所述的一种基于鸡蛋胚胎血流信息的心律测量方法,其特征在于:步骤2的子步骤包括:2. a kind of heart rhythm measurement method based on egg embryo blood flow information according to claim 1, is characterized in that: the sub-step of step 2 comprises: 步骤2.1、通过OCT扫描系统对位置线区间进行两次截面扫描,得到第一截面图和第二截面图;Step 2.1, perform two cross-sectional scans on the position line interval through the OCT scanning system to obtain the first cross-sectional view and the second cross-sectional view; 步骤2.2、对第一截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第一相位信息;对第二截面图进行非节点边界三次样条插值处理后再进行傅里叶变换得到相位信息,所述相位信息记为第二相位信息;Step 2.2: Perform non-node boundary cubic spline interpolation processing on the first cross-sectional image, and then perform Fourier transform to obtain phase information, which is recorded as the first phase information; perform non-node boundary cubic spline sampling on the second cross-sectional image. After the strip interpolation processing, Fourier transform is performed to obtain phase information, and the phase information is denoted as second phase information; 步骤2.3、根据速度模型得到血流在所述位置线区间的速度信息;Step 2.3, obtaining the velocity information of the blood flow in the position line interval according to the velocity model; 步骤2.4、重复步骤2.1至步骤2.3直至得到所有位置线区间的速度信息;Step 2.4, repeat steps 2.1 to 2.3 until the speed information of all position line intervals is obtained; 其中,所述速度模型为:Wherein, the speed model is:
Figure FDA0002282186240000011
Figure FDA0002282186240000011
v表示为速度信息,λ表示为OCT扫描系统中检测光的波长,Φ1表示为第一相位信息,Φ2表示为第二相位信息,i表示为复审虚部的符号,Im表示为提取复审的虚部,Re表示为提取复数的实部。v is the velocity information, λ is the wavelength of the detected light in the OCT scanning system, Φ 1 is the first phase information, Φ 2 is the second phase information, i is the symbol of the imaginary part of the review, Im is the extraction review The imaginary part of , Re is denoted to extract the real part of the complex number.
3.根据权利要求1所述的一种基于鸡蛋胚胎血流信息的心律测量方法,其特征在于:所述扫描区域的尺寸为2.5mm*2.5mm。3 . The method for measuring heart rhythm based on egg embryo blood flow information according to claim 1 , wherein the size of the scanning area is 2.5mm*2.5mm. 4 .
CN201911145896.1A 2019-11-21 2019-11-21 Heart rhythm measuring method based on egg embryo blood flow information Pending CN111297342A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911145896.1A CN111297342A (en) 2019-11-21 2019-11-21 Heart rhythm measuring method based on egg embryo blood flow information

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911145896.1A CN111297342A (en) 2019-11-21 2019-11-21 Heart rhythm measuring method based on egg embryo blood flow information

Publications (1)

Publication Number Publication Date
CN111297342A true CN111297342A (en) 2020-06-19

Family

ID=71144840

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911145896.1A Pending CN111297342A (en) 2019-11-21 2019-11-21 Heart rhythm measuring method based on egg embryo blood flow information

Country Status (1)

Country Link
CN (1) CN111297342A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275812A1 (en) * 2008-03-04 2009-11-05 Glucolight Corporation Flowometry in Optical Coherence Tomography for Analyte Level Estimation
KR20120134477A (en) * 2011-06-02 2012-12-12 경북대학교 산학협력단 Pulse analyzing system using optical coherence tomography for oriental medical and the method
US20140236002A1 (en) * 2011-10-17 2014-08-21 University Of Washington Through Its Center For Commercialization Methods and Systems for Imaging Tissue Motion Using Optical Coherence Tomography
CN109431484A (en) * 2018-12-10 2019-03-08 佛山科学技术学院 A kind of device and method of the egg Embryo sexing based on heart rate measurement

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275812A1 (en) * 2008-03-04 2009-11-05 Glucolight Corporation Flowometry in Optical Coherence Tomography for Analyte Level Estimation
KR20120134477A (en) * 2011-06-02 2012-12-12 경북대학교 산학협력단 Pulse analyzing system using optical coherence tomography for oriental medical and the method
US20140236002A1 (en) * 2011-10-17 2014-08-21 University Of Washington Through Its Center For Commercialization Methods and Systems for Imaging Tissue Motion Using Optical Coherence Tomography
CN109431484A (en) * 2018-12-10 2019-03-08 佛山科学技术学院 A kind of device and method of the egg Embryo sexing based on heart rate measurement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IRINA V. LARINA 等: "Live imaging of blood flow in mammalian embryos using Doppler swept-source optical coherence tomography", 《JOURNAL OF BIOMEDICAL OPTICS》 *
窦世丹: "基于光学相干层析成像的胚胎心脏血流参数研究", 《中国优秀博硕士学位论文全文数据库(硕士) 医药卫生科技辑》 *

Similar Documents

Publication Publication Date Title
JP5788174B2 (en) Real-time spectral domain optical coherence tomography using distributed acquisition and processing
Yang et al. EDA-Net: dense aggregation of deep and shallow information achieves quantitative photoacoustic blood oxygenation imaging deep in human breast
JP4454030B2 (en) Image processing method for three-dimensional optical tomographic image
EP1910997B1 (en) Methods, systems and computer program for 3d-registration of three dimensional data sets obtained by preferably optical coherence tomography based on the alignment of projection images or fundus images, respectively
US9858668B2 (en) Guidewire artifact removal in images
US12249052B2 (en) Correction of flow projection artifacts in octa volumes using neural networks
EP3494880A1 (en) Automatic stent detection
US20140099011A1 (en) Removal of a-scan streaking artifact
CN105342568B (en) The optical coherence angiographic method and system of joint phase and amplitude
EP2903532A2 (en) Methods and systems for establishing parameters, playback, and artifact removal three-dimensional imaging
CN107862724B (en) Improved microvascular blood flow imaging method
US9471975B2 (en) Methods, systems and computer program products for dynamic optical histology using optical coherence tomography
WO2014100291A1 (en) System and method for imaging subsurface of specimen
Nogueira et al. Tissue biomolecular and microstructure profiles in optical colorectal cancer delineation
KR100982619B1 (en) Non-invasive early diagnosis method and device of fruit disease
KR101442708B1 (en) Optical coherence tomography for processing three-dimensional oct data using 64 bit based dynamic memory allocation method
Alexandrov et al. Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
CN105654497B (en) A kind of time reversal method for reconstructing of intravascular photoacoustic image
Sun et al. Real-time optical-resolution photoacoustic endoscope
CN111297342A (en) Heart rhythm measuring method based on egg embryo blood flow information
Chen et al. Cube data correlation-based imaging of small blood vessels
US11779277B2 (en) Systems and methods for endovascular device detection and apposition measurement
Elahi et al. Complex regression Doppler optical coherence tomography
Smirni et al. In-vivo assessment of microvascular functional dynamics by combination of cmOCT and wavelet transform
JP2018102359A (en) Processing apparatus and processing method

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Country or region after: China

Address after: No.33 Guangyun Road, Shishan town, Nanhai District, Foshan City, Guangdong Province

Applicant after: Foshan University

Address before: No.33 Guangyun Road, Shishan town, Nanhai District, Foshan City, Guangdong Province

Applicant before: FOSHAN University

Country or region before: China

CB02 Change of applicant information