CN1112004A - Spray for treating cold and sore-throat and its preparing method - Google Patents
Spray for treating cold and sore-throat and its preparing method Download PDFInfo
- Publication number
- CN1112004A CN1112004A CN 94115091 CN94115091A CN1112004A CN 1112004 A CN1112004 A CN 1112004A CN 94115091 CN94115091 CN 94115091 CN 94115091 A CN94115091 A CN 94115091A CN 1112004 A CN1112004 A CN 1112004A
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- Prior art keywords
- distilled water
- add
- sore
- spray
- alcohol
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- Pending
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- 239000007921 spray Substances 0.000 title claims abstract description 15
- 206010068319 Oropharyngeal pain Diseases 0.000 title claims description 12
- 201000007100 Pharyngitis Diseases 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 19
- 239000012153 distilled water Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 8
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 229960004756 ethanol Drugs 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 241000411851 herbal medicine Species 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 4
- 244000025254 Cannabis sativa Species 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 229910000831 Steel Inorganic materials 0.000 claims description 2
- 102000011759 adducin Human genes 0.000 claims description 2
- 108010076723 adducin Proteins 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000010959 steel Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000596154 Belamcanda Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000011479 upper respiratory tract disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000000857 drug effect Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- NQOFOJJYNLBNCM-UHFFFAOYSA-N [Na].C1=CC=CC=C1.CC1=CC=CC=C1 Chemical compound [Na].C1=CC=CC=C1.CC1=CC=CC=C1 NQOFOJJYNLBNCM-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The spray for curing cold and upper respiratory tract disease with obvious curative effect is prepared from 7 Chinese-medicinal materials including honeysuckle flower, forsythia fruit, subprostrate sophora root, belamcanda rhizome, magnolia bark, etc. and others through preparing Chinese-medicinal extract and mixing it with alcohol, distilled water and sodium benzoate and features no toxic by-effect.
Description
What the present invention relates to is a kind of medicine for the treatment of diseases caused by exogenous pathogenic factor and upper respiratory tract illness and produces its method.
Flu is that a kind of regular incidence, frequently-occurring disease, sickness rate are up to more than 25%, clinically except that features such as nasal obstruction, watery nasal discharge, sneeze, cough, headache, aversion to cold, heating, general malaise are arranged, and the normal symptoms such as rhinitis, sinusitis, upper respiratory tract infection that cause.Generally adopt oral at present or the injection Pharmaceuticals is treated, the one, all there is certain toxic and side effects in chemicals, and the 2nd, curative effect is relatively poor, takes sometimes to take orally, the multiple medicine of external starts at the same time, also is difficult to prove effective.
The objective of the invention is to avoid the deficiencies in the prior art, and a kind of inner disease outer treat, good effect are provided, without any side effects drives sense sore-throat relieving spray product and produces its method.
Can take following technical scheme to realize purpose.Extractum with Chinese herbal medicine Flos Lonicerae, Fructus Forsythiae, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Cortex Magnoliae Officinalis, Radix Platycodonis, Herba Menthae is active ingredient, and the additive preparing of forming with ethanol, distilled water, sodium benzoate forms.After earlier the medium-height grass medicinal alcohol being extracted respectively as solvent when producing, promptly get the sense sore-throat relieving spray that drives of the present invention with ethanol, distilled water, sodium benzoate mixing preparation again.
Be described in further detail in conjunction with the content of embodiment the technical program.
Both can adopt their primary crude drug to Flos Lonicerae, Fructus Forsythiae, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Cortex Magnoliae Officinalis, a few flavor Chinese herbal medicine of Radix Platycodonis, also can adopt commercially available decoction pieces through processing; Equally, can adopt primary crude drug, also can directly adopt the Mentholum that therefrom extracts Herba Menthae.The pattern of medical material is to driving the not influence of drug effect of sense sore-throat relieving spray, and just technical process is complicated and simple, adopts decoction pieces, Mentholum then can make technology simple.Their consumption can be selected by conventional the taking the circumstances into consideration of the traditional Chinese medical science.Additives are made up of ethanol, distilled water and sodium benzoate, the effect of ethanol, distilled water is as the solvent of Chinese herbal medicine active ingredient, diluent, benzene toluene sodium is as the antiseptic of herb liquid, and selected concentration of ethanol does not have influence to the effectiveness of driving sense sore-throat relieving spray.The proportionate relationship of Chinese herbal medicine active ingredient and additives consumption, promptly dilute strength also can be handled routinely.
During preparation, should earlier the medium-height grass medicinal alcohol be extracted active ingredient respectively as solvent, make extractum after, evenly promptly get preparation of the present invention with the additives mixing preparation again.
Drive in the sense sore-throat relieving spray, their consumption is pressed the spray total weight:
Flos Lonicerae 9.75-10.25%, Fructus Forsythiae 4.25-4.75%,
Radix Sophorae Tonkinensis 2.75-3.25%, Rhizoma Belamcandae 2.25-2.75%,
Cortex Magnoliae Officinalis 2.25-2.75%, Radix Platycodonis 1.25-1.75%,
Mentholum 0.05-0.25%,
Dehydrated alcohol 10-14%, distilled water 64-85%,
Benzoic acid steel 0.5-1%.
And be prepared in the following manner:
When 1, extracting Flos Lonicerae, Fructus Forsythiae medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 5-6, just soak four hours post-heating in advance, extract three times, extracted 40 minutes at every turn.Filtrate with three extractions makes alcohol reflux be condensed into fluid extract under 80 ℃, and fluid extract proportion 1.15-1.20 is standby.
When extracting Rhizoma Belamcandae, Cortex Magnoliae Officinalis medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 3-4, soak four hours post-heating, extract three times, each 40 minutes, the filtrate with three extractions made alcohol reflux be condensed into fluid extract under 80 ℃, and proportion 1.15-1.20 is standby.
When extracting Radix Sophorae Tonkinensis, withered stalk medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 2-3, soak four hours post-heating, extract each 40 minutes three times.Filtrate with three extractions makes alcohol reflux be condensed into fluid extract under 80 ℃, and proportion 1.15-1.20 is standby.
The Mentholum crystalline solid, it is an amount of to add 95% ethanol, dissolves with crystal to be as the criterion, standby.
Ethanol is poured in the distilled water, and mixing is made and is contained pure distilled water.
2, the fluid extract that last process extracted is concerned in proportion that mix homogeneously adds while stirring then and contains pure distilled water; Place after 24 hours, select for use 201 type quantitative filter papers to filter fast, add again in the filtrate sodium benzoate mixing required preparation.
By the preparation that this proportionate relationship and mode was mixed with, result of use the best.
Example: by above best mode, as solvent, extract the extractum of each Chinese herbal medicine respectively with ethanol, with extractum:
Flos Lonicerae 9.75%, Fructus Forsythiae 4.25%,
Radix Sophorae Tonkinensis 2.75%, Rhizoma Belamcandae 2.25%,
Cortex Magnoliae Officinalis 2.25%, Radix Platycodonis 1.25%,
Mentholum 0.05% mix homogeneously adds then while stirring:
Dehydrated alcohol 10%, the solvent of distilled water 66.95% was placed after 24 hours, selected the low filtration fast of the quantitative filter of 201 types for use, added 0.5% sodium benzoate mix homogeneously in the filtrate again, and the sore-throat relieving spray is felt in driving of obtaining.
Or with extractum:
Flos Lonicerae 10.25%, Fructus Forsythiae 4.75%,
Radix Sophorae Tonkinensis 3.25%, Rhizoma Belamcandae 2.75%,
Cortex Magnoliae Officinalis 2.75%, Radix Platycodonis 1.75%,
Mentholum 0.25%, with dehydrated alcohol 14%,
Distilled water 59.25%, the preparation that sodium benzoate 1% mix homogeneously obtains.All has optimum curative effect.
The sense sore-throat relieving spray of making by the technical program that drives has following advantage:
1, pure Chinese medicinal preparation has no side effect to human body, and non-corrosiveness is free from environmental pollution, and is safe and reliable.
2, prevention and treatment diseases caused by exogenous pathogenic factor and the pharyngeal illness effect of complication mouth and nose thereof are remarkable, and be strong to various bacteria and influenza virus sterilizing power, is a kind of active drug of inner disease outer treat;
3, efficacy stability deposits that drug effect does not subtract more than 2 years.
Claims (4)
1, a kind of sense sore-throat relieving spray that drives, it is characterized in that: it is that extractum with Chinese herbal medicine Flos Lonicerae, Fructus Forsythiae, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Cortex Magnoliae Officinalis, Radix Platycodonis, Herba Menthae is active ingredient, the goods that the additives mixing preparation of forming with ethanol, distilled water, sodium benzoate forms.
2, a kind of described sense sore-throat relieving spray preparing process of driving of claim 1 that is used for is characterized in that: after it extracts the medium-height grass medicinal alcohol respectively as solvent earlier, again with ethanol, distilled water, sodium benzoate additives mixing preparation.
3, the sense sore-throat relieving spray that drives as claimed in claim 1 is characterized in that: their consumption, press the spray total weight:
Flos Lonicerae 9.75-10.25%, Fructus Forsythiae 4.25-4.75%,
Radix Sophorae Tonkinensis 2.75-3.25%, Rhizoma Belamcandae 2.25-2.75%,
Cortex Magnoliae Officinalis 2.25-2.75%, Radix Platycodonis 1.25-1.75%,
Mentholum 0.05-0.25%,
Dehydrated alcohol 10-14%, distilled water 64-85%,
Benzoic acid steel 0.5-1%.
4, preparation method as claimed in claim 2 is characterized in that:
When a, extraction Flos Lonicerae, Fructus Forsythiae medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 5-6, just soak four hours post-heating in advance, extract three times, extracted 40 minutes at every turn, the filtrate with three extractions makes alcohol reflux be condensed into fluid extract under 80 ℃, and is standby;
When extracting Rhizoma Belamcandae, Cortex Magnoliae Officinalis medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 3-4, soak four hours post-heating, extract three times, each 40 minutes, the filtrate with three extractions makes alcohol reflux be condensed into fluid extract under 80 ℃, and was standby;
When extracting Radix Sophorae Tonkinensis, Radix Platycodonis medicinal liquid, press crude drug weight and add doubly 95% alcohol solvent of 2-3, soak four hours post-heating, extract three times, each 40 minutes, the filtrate with three extractions makes alcohol reflux be condensed into fluid extract under 80 ℃, and was standby;
With the Mentholum crystalline solid, it is an amount of to add 95% ethanol, dissolves to crystal to be as the criterion, standby;
B, the fluid extract that last process extracted is concerned mix homogeneously in proportion, add while stirring then and contain pure distilled water; Place after 24 hours, select for use 201 type quantitative filter papers to filter fast; In filtrate, add the sodium benzoate mixing, required preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94115091 CN1112004A (en) | 1994-08-26 | 1994-08-26 | Spray for treating cold and sore-throat and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94115091 CN1112004A (en) | 1994-08-26 | 1994-08-26 | Spray for treating cold and sore-throat and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1112004A true CN1112004A (en) | 1995-11-22 |
Family
ID=5037358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94115091 Pending CN1112004A (en) | 1994-08-26 | 1994-08-26 | Spray for treating cold and sore-throat and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1112004A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055410C (en) * | 1997-05-26 | 2000-08-16 | 朱进忠 | Medicine for curing acute tonsillitis and upper respiratory tract infection and its preparing method |
| JP2008517999A (en) * | 2004-10-27 | 2008-05-29 | エスケー ケミカルズ カンパニー リミテッド | Bitter extract useful for prevention and treatment of respiratory diseases |
-
1994
- 1994-08-26 CN CN 94115091 patent/CN1112004A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055410C (en) * | 1997-05-26 | 2000-08-16 | 朱进忠 | Medicine for curing acute tonsillitis and upper respiratory tract infection and its preparing method |
| JP2008517999A (en) * | 2004-10-27 | 2008-05-29 | エスケー ケミカルズ カンパニー リミテッド | Bitter extract useful for prevention and treatment of respiratory diseases |
| EP1811940A4 (en) * | 2004-10-27 | 2009-12-02 | Sk Chemicals Co Ltd | Sophorae subprostratae radix extract for prevention and treatment of respiratory diseases |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |