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CN111163778A - 一种mor受体激动剂药物组合物 - Google Patents

一种mor受体激动剂药物组合物 Download PDF

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Publication number
CN111163778A
CN111163778A CN201980004491.8A CN201980004491A CN111163778A CN 111163778 A CN111163778 A CN 111163778A CN 201980004491 A CN201980004491 A CN 201980004491A CN 111163778 A CN111163778 A CN 111163778A
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CN
China
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
present disclosure
oxaspiro
methoxy
Prior art date
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CN201980004491.8A
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English (en)
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CN111163778B (zh
Inventor
杨晓容
蒋艳霞
陈昊
贺峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Chengdu Suncadia Pharmaceuticals Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Chengdu Suncadia Pharmaceuticals Co Ltd
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Publication of CN111163778A publication Critical patent/CN111163778A/zh
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Publication of CN111163778B publication Critical patent/CN111163778B/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

本披露中涉及一种MOR受体激动剂药物组合物。具体而言，本披露涉及的MOR受体激动剂药物组合物其包含(1S,4S)‑4‑甲氧基‑N‑(2‑((R)‑9‑(吡啶‑2‑基)‑6‑氧杂螺[4.5]癸烷‑9‑基)乙基)‑1,2,3,4‑四氢萘‑1‑胺或其可药用盐，和磷酸盐缓冲液。本披露中之药物组合物在储存数月之后展现了良好的稳定性。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980004491.8A 2018-05-14 2019-05-13 一种mor受体激动剂药物组合物 Active CN111163778B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810455502 2018-05-14
CN2018104555021 2018-05-14
PCT/CN2019/086544 WO2019218953A1 (zh) 2018-05-14 2019-05-13 一种mor受体激动剂药物组合物

Publications (2)

Publication Number Publication Date
CN111163778A true CN111163778A (zh) 2020-05-15
CN111163778B CN111163778B (zh) 2023-01-24

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ID=68539514

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CN201980004491.8A Active CN111163778B (zh) 2018-05-14 2019-05-13 一种mor受体激动剂药物组合物

Country Status (3)

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CN (1) CN111163778B (zh)
TW (1) TW202015678A (zh)
WO (1) WO2019218953A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026007980A1 (zh) * 2024-07-03 2026-01-08 上海海雁医药科技有限公司 一种mor受体激动剂的液体组合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090028873A1 (en) * 2007-07-27 2009-01-29 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
PL3290415T3 (pl) * 2011-03-23 2021-07-19 Trevena, Inc. Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI,XIN ET AL.: "《Discovery of SHR9352: A Highly Potent G Protein-Based u-Opioid Receptor Agonist》", 《ACS OMEGA》 *

Also Published As

Publication number Publication date
TW202015678A (zh) 2020-05-01
WO2019218953A1 (zh) 2019-11-21
CN111163778B (zh) 2023-01-24

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