CN111166899A - Moist heat sterilization method for sorbitol eye drops - Google Patents
Moist heat sterilization method for sorbitol eye drops Download PDFInfo
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- CN111166899A CN111166899A CN202010012062.XA CN202010012062A CN111166899A CN 111166899 A CN111166899 A CN 111166899A CN 202010012062 A CN202010012062 A CN 202010012062A CN 111166899 A CN111166899 A CN 111166899A
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- sorbitol
- eye drops
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/12—Microwaves
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- A61L2103/05—
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
本发明公开了山梨醇滴眼液湿热灭菌方法，包括以下步骤：步骤一，将山梨醇滴眼液先采用微波处理20‑30min，微波的功率为100‑200W，然后静置10‑20min，再采用微波二段处理5‑10min。本发明从实施例1‑3灭菌率均达到99％以上，采用本发明的方法可有效的达到灭菌效果，本发明先采用微波处理，然后再进行湿热灭菌，湿热灭菌中伴随着高压脉冲电场处理，同时湿热灭菌中对温度的精准控制，从而相比现有的技术，可显著改善灭菌的效果，具有优异的效果。The invention discloses a moist heat sterilization method for sorbitol eye drops, comprising the following steps: step 1, first microwave the sorbitol eye drops for 20-30min, the power of the microwave is 100-200W, and then stand for 10-20min, Then use the second stage of microwave treatment for 5-10min. In the present invention, the sterilization rate from Examples 1-3 all reaches more than 99%, and the method of the present invention can effectively achieve the sterilization effect. The present invention adopts microwave treatment first, and then performs moist heat sterilization. High-voltage pulsed electric field treatment and precise temperature control in moist heat sterilization can significantly improve the sterilization effect compared to the existing technology, with excellent results.
Description
Technical Field
The invention relates to the technical field of eye drop treatment, in particular to a moist heat sterilization method for sorbitol eye drops.
Background
Aiming at the phenomena that modern people often watch a display screen, or fatigue of eyes and teenagers' myopia are more serious due to high-intensity work, the number of the myopia is more and more serious, glasses are worn at small ages, the degree of the glasses is increased year by year, and the glasses are not reduced, the eyes are relaxed or corrected for eyesight, medicines are applied to the eyes, the fatigue of the eyes is relieved finally, and the myopia is prevented.
Sorbitol eye drops are polluted in production, so that the sorbitol eye drops need to be sterilized, the existing sterilization method is simple, the obtained effect is conceivable, and further improvement treatment is still needed.
Disclosure of Invention
The invention aims to provide a method for moist heat sterilization of sorbitol eye drops, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the wet heat sterilization method of the sorbitol eye drops comprises the following steps:
firstly, treating the sorbitol eye drops by microwaves for 20-30min, wherein the power of the microwaves is 100-200W, then standing for 10-20min, and then treating for 5-10min by microwaves for two stages;
step two, adding the sorbitol eye drops processed in the step one into a processor, standing for 20-30min, starting the processor, raising the temperature of the processor to 60 ℃, and preserving the heat for 20-30 min;
thirdly, increasing the temperature to 90-100 ℃ at the speed of 2 ℃/min, continuing to preserve heat for 15-25min, and then starting a high-voltage pulse electric field;
and step four, cooling the temperature to room temperature after the high-voltage pulse electric field treatment, then standing for 15-25min, and taking out after standing to obtain the sterilized sorbitol eye drops.
Preferably, the microwave power of the microwave secondary treatment in the first step is 50-100W.
Preferably, the microwave power of the microwave secondary treatment in the first step is 75W.
Preferably, the processor in the second step is a wet heat sterilizer which has the functions of regulating pressure and temperature and is accompanied by a high-voltage pulse electric field in the processor.
Preferably, the frequency of the electric field of the high-voltage pulse electric field in the third step is 30-50Hz, the pulse width is 10-40us, the strength of the battery is 25-35v/m, and the action time of the battery is 10-30 min.
Preferably, the electric field frequency of the high-voltage pulse electric field in the third step is 40Hz, the pulse width is 25us, the battery strength is 30v/m, and the battery action time is 20 min.
Preferably, the specific operation steps of reducing the temperature to room temperature in the fourth step are as follows: reducing the temperature to 60 ℃ at the speed of 5 ℃/min, then preserving the heat for 10-20min, and then continuously reducing the temperature to the room temperature at the speed of 1-3 ℃/min.
Compared with the prior art, the invention has the following beneficial effects:
the sterilization rate of the invention reaches more than 99 percent from the examples 1-3, the sterilization effect can be effectively achieved by adopting the method of the invention, the invention adopts the microwave treatment firstly, and then carries out the damp heat sterilization, the damp heat sterilization is accompanied with the high-voltage pulse electric field treatment, and the temperature is accurately controlled in the damp heat sterilization, thereby compared with the prior art, the sterilization effect can be obviously improved, and the invention has excellent effect.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the sorbitol eye drop moist heat sterilization method of the embodiment comprises the following steps:
firstly, treating the sorbitol eye drops by microwaves for 20min, wherein the power of the microwaves is 100W, then standing for 10min, and then treating for 5min by microwaves for two stages;
step two, adding the sorbitol eye drops processed in the step one into a processor, standing for 20min, starting the processor, raising the temperature of the processor to 60 ℃, and preserving the heat for 20 min;
thirdly, raising the temperature to 90 ℃ at the speed of 2 ℃/min, continuing to preserve heat for 15min, and then starting a high-voltage pulse electric field;
and step four, cooling the temperature to room temperature after the high-voltage pulse electric field treatment, then standing for 15min, and taking out after standing to obtain the sterilized sorbitol eye drops.
In the first step of this embodiment, the microwave power of the microwave secondary treatment is 50W.
The processor in the second step of this embodiment is a moist heat sterilizer, which has the functions of pressure and temperature regulation and is accompanied by a high-voltage pulse electric field inside the processor.
In the third step of this embodiment, the frequency of the high-voltage pulse electric field is 30Hz, the pulse width is 10us, the battery strength is 25v/m, and the battery action time is 10 min.
In the fourth step of this embodiment, the specific operation steps of reducing the temperature to room temperature are as follows: the temperature is reduced to 60 ℃ at the speed of 5 ℃/min, then the temperature is preserved for 10min, and then the temperature is reduced to room temperature at the speed of 1 ℃/min.
Example 2:
the sorbitol eye drop moist heat sterilization method of the embodiment comprises the following steps:
firstly, treating the sorbitol eye drops by microwaves for 30min, wherein the power of the microwaves is 200W, then standing for 20min, and then treating for 10min by microwaves for two stages;
step two, adding the sorbitol eye drops processed in the step one into a processor, standing for 30min, starting the processor, raising the temperature of the processor to 60 ℃, and preserving the temperature for 30 min;
thirdly, raising the temperature to 100 ℃ at the speed of 2 ℃/min, keeping the temperature for 25min, and then starting a high-voltage pulse electric field;
and step four, cooling the temperature to room temperature after the high-voltage pulse electric field treatment, then standing for 25min, and taking out after standing to obtain the sterilized sorbitol eye drops.
In the first step of this embodiment, the microwave power of the microwave secondary treatment is 100W.
The processor in the second step of this embodiment is a moist heat sterilizer, which has the functions of pressure and temperature regulation and is accompanied by a high-voltage pulse electric field inside the processor.
In the third step of this embodiment, the frequency of the high-voltage pulse electric field is 50Hz, the pulse width is 40us, the battery strength is 35v/m, and the battery action time is 30 min.
In the fourth step of this embodiment, the specific operation steps of reducing the temperature to room temperature are as follows: the temperature is reduced to 60 ℃ at the speed of 5 ℃/min, then the temperature is preserved for 20min, and then the temperature is reduced to room temperature at the speed of 3 ℃/min.
Example 3:
the sorbitol eye drop moist heat sterilization method of the embodiment comprises the following steps:
firstly, treating the sorbitol eye drops by microwaves for 25min, wherein the power of the microwaves is 150W, then standing for 15min, and then treating for 7.5min by microwaves for two periods;
step two, adding the sorbitol eye drops processed in the step one into a processor, standing for 25min, starting the processor, raising the temperature of the processor to 60 ℃, and keeping the temperature for 25 min;
thirdly, raising the temperature to 95 ℃ at the speed of 2 ℃/min, continuing to preserve heat for 20min, and then starting a high-voltage pulse electric field;
and step four, cooling the temperature to room temperature after the high-voltage pulse electric field treatment, then standing for 20min, and taking out after standing to obtain the sterilized sorbitol eye drops.
In the first step of this embodiment, the microwave power of the microwave secondary treatment is 75W.
The processor in the second step of this embodiment is a moist heat sterilizer, which has the functions of pressure and temperature regulation and is accompanied by a high-voltage pulse electric field inside the processor.
In the third step of this embodiment, the frequency of the high-voltage pulse electric field is 40Hz, the pulse width is 25us, the battery strength is 30v/m, and the battery action time is 20 min.
In the fourth step of this embodiment, the specific operation steps of reducing the temperature to room temperature are as follows: the temperature is reduced to 60 ℃ at the speed of 5 ℃/min, then the temperature is preserved for 15min, and then the temperature is reduced to room temperature at the speed of 2 ℃/min.
Examples 1-3 the results of the performance test are as follows
| Sterilization (%) | |
| Example 1 | 99.4 |
| Example 2 | 99.5 |
| Example 3 | 99.9 |
From the examples 1-3, the sterilization rate of the example 3 of the invention is more than 99%, and the sterilization effect can be effectively achieved by adopting the method of the invention.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
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| CN202010012062.XA CN111166899A (en) | 2020-01-07 | 2020-01-07 | Moist heat sterilization method for sorbitol eye drops |
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| CN202010012062.XA CN111166899A (en) | 2020-01-07 | 2020-01-07 | Moist heat sterilization method for sorbitol eye drops |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939278A (en) * | 2020-07-31 | 2020-11-17 | 珠海润都制药股份有限公司 | Sterilization process of higenamine hydrochloride injection |
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| CN110140909A (en) * | 2019-05-30 | 2019-08-20 | 重庆康菌泰生物科技股份有限公司 | A kind of Rosa roxburghii Tratt comprehensive enzyme and preparation method thereof |
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2020
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| WO2010054113A2 (en) * | 2008-11-06 | 2010-05-14 | Amira Pharmaceuticals, Inc. | Cycloalkane[b]azaindole antagonists of prostaglandin d2 receptors |
| CN105412003A (en) * | 2014-09-12 | 2016-03-23 | 广东东阳光药业有限公司 | Besifloxacin hydrochloride eye drops and preparation method thereof |
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| CN111939278A (en) * | 2020-07-31 | 2020-11-17 | 珠海润都制药股份有限公司 | Sterilization process of higenamine hydrochloride injection |
| CN111939278B (en) * | 2020-07-31 | 2021-08-17 | 珠海润都制药股份有限公司 | A kind of sterilization process of higenamine hydrochloride injection |
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Application publication date: 20200519 |