CN111166805A - Preparation method and application of plant extract for treating tonsillitis and pharyngolaryngitis - Google Patents
Preparation method and application of plant extract for treating tonsillitis and pharyngolaryngitis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a preparation method and application of a plant extract for treating tonsillitis and pharyngolaryngitis, which comprises the following steps: s1, extracting immersion liquid: mixing radix Cyathulae, herba Moslae, JIANGHUANWANGCHA, and water, and heating to obtain water extractive solution; s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate; s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid; s4, filling and sterilizing: filling the water-extracted fine-filtered oxidized liquid obtained in the step S3 into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product; the invention combines medicinal cyathula root, elsholtzia and Jianghua bitter tea, fills oxygen into water extraction fine filtration liquid, mixes and oxidizes the mixture to obtain water extraction fine filtration oxidation liquid, and fully dissolves and combines the effective components of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea, thereby having remarkable effect of treating tonsillitis and pharyngitis without any side effect.
Description
Technical Field
The invention belongs to the technical field of plant extraction and biological pharmacy, and particularly relates to a preparation method and application of a plant extract for treating tonsillitis and pharyngolaryngitis.
Background
At present, the oxidation of a human body is aggravated, the immunity of the human body is reduced and the resistance is reduced due to environmental pollution and food pollution; acute and chronic pharyngolaryngitis and tonsillitis are common, and especially tonsillitis is easily obtained by children; seriously harming the health of people; the treatment with chemical drugs has certain side effects, and particularly, the drug resistance is easy to generate when the treatment is used for a plurality of times.
Radix Cyathulae, herba Moslae and Jianghua bitter tea are known to have the function of resisting respiratory tract inflammation; the effect of resisting respiratory tract inflammation is enhanced through a reasonable formula and a certain process technology, and the plant water extract oral liquid for treating tonsillitis and sphagitis with good effect is of great significance.
Disclosure of Invention
The invention aims to: provides a preparation method and application of a plant extract for treating tonsillitis and pharyngolaryngitis.
The technical scheme adopted by the invention is as follows: a preparation method of a plant extract for treating tonsillitis and pharyngolaryngitis is characterized by comprising the following steps:
s1, extracting immersion liquid: mixing radix Cyathulae, herba Moslae, JIANGHUANWANGCHA, and water, and heating to obtain water extractive solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
The reaction mechanism of the invention is as follows: the invention combines medicinal cyathula root, elsholtzia and Jianghua bitter tea, fills oxygen into water extraction fine filtration liquid, mixes and oxidizes the mixture to obtain water extraction fine filtration oxidation liquid, and fully dissolves and combines the effective components of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea, thereby having remarkable effect of treating tonsillitis and pharyngitis without any side effect.
Further, the extraction of the extract from the medicinal cyathula root in step S1: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 3-5: 1-4: 1-3: 10-60, heating and extracting at 80-100 deg.C for 40-150 min; through a large number of experiments, the optimal proportion, extraction temperature and extraction time are obtained, and the effective ingredients in the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea can be fully dissolved in water, so that the raw materials are utilized to the maximum extent.
Further, radix cyathulae is replaced by radix achyranthis bidentatae or radix achyranthis bidentatae; the two kinds have similar effects and can be used alternatively.
Further, the impurities removed by the filtration in the step S2 are substances larger than 0.25 micron, and the pore size of the filtration membrane used for the filtration is smaller than or equal to 0.25 micron; the water extraction fine filtration liquid has high purity and no precipitation impurity.
Further, the oxidation time in step S3 is: 0.3-3.5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 4 times per hour; the consumption of edible or medical oxygen is 1-9 cubic meters per ton of extracting solution under one atmosphere; through oxidation reaction, the medicine effect is better, the effect is obvious when the medicine is taken by patients with tonsillitis and sphagitis through Yao medicine, and the actual effect is good.
Further, the temperature for sterilization in the filling and sterilizing in the step S4 is 104 to 128 ℃; the time is 10 to 90 minutes; the product is sterilized after being filled, so that the curative effect of the product during the shelf life is ensured.
Further, in the step S4, the capacity of the oral liquid bottle during filling and sterilizing is 10-50 ml/piece of the oral liquid bottle; the qualified oral liquid bottle can be selected according to the dose.
The plant extract for treating tonsillitis and pharyngolaryngitis has application in preparing traditional Chinese medicines for treating tonsillitis and pharyngolaryngitis; can be used for treating tonsillitis and pharyngolaryngitis with good therapeutic effect.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
the invention has simple process, high extraction and utilization rate of effective components, obvious administration effect, homology of medicine and food and no toxic or side effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A preparation method of plant extract for treating tonsillitis and pharyngolaryngitis is characterized by comprising the following steps:
s1, extracting immersion liquid: mixing radix Cyathulae, herba Moslae, JIANGHUANWANGCHA, and water, and heating to obtain water extractive solution; the radix cyathulae of the extract is: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 3-5: 1-4: 1-3: 10-60, heating and extracting at 80-100 deg.C for 40-150 min; through a large number of experiments, the optimal proportion, extraction temperature and extraction time are obtained, and the effective ingredients in the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea can be fully dissolved in water, so that the raw materials are utilized to the maximum extent.
S2, filtering: filtering the water extracting solution obtained in the step S1 through a filter membrane to remove impurities, wherein the impurities removed by filtering are substances larger than 0.25 micron, and the aperture of the filter membrane used for filtering is smaller than or equal to 0.25 micron; obtaining water extraction fine filtration liquid;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid; the time of the oxidation is as follows: 0.3-3.5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 4 times per hour; the consumption of edible or medical oxygen is 1-9 cubic meters per ton of extracting solution under one atmosphere; through oxidation reaction, the medicine effect is better, the effect is obvious when the medicine is taken by patients with tonsillitis and sphagitis through Yao medicine, and the actual effect is good.
S4, filling and sterilizing: filling the water-extracted fine-filtered oxidized liquid obtained in the step S3 into 10-50 ml/per oral liquid bottle, and sterilizing at high temperature to obtain a finished product; the sterilization temperature in the filling sterilization is 104-128 ℃; the time is 10 to 90 minutes; the product is sterilized after being filled, so that the curative effect of the product during the shelf life is ensured.
The plant extract for treating tonsillitis and pharyngolaryngitis has application in preparing traditional Chinese medicines for treating tonsillitis and pharyngolaryngitis; can be used for treating tonsillitis and pharyngolaryngitis with good therapeutic effect.
Examples of the present invention are given below
Example 1
S1, extracting immersion liquid: mixing 25 kg of achyranthes aspera, 15 kg of elsholtzia, 10 kg of Jianghua bitter tea and 500 liters of water, heating to 95 ℃, and extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.25 micron to obtain water extraction fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 80 ℃; then filling edible or medical oxygen into the water extraction fine filtration liquid, wherein the total dosage is 2 cubic meters under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1200 liters per hour; the time from the beginning of oxygenation to the end of oxygenation is 150 minutes, and water extraction, fine filtration and oxidation liquid is obtained;
s4, sterilization: filling the oxidized water extraction fine filtration oxidation liquid into each 50 ml oral liquid bottle and screwing the cover tightly; placing the filled bottles into a sterilization cabinet, heating to 108 ℃ and sterilizing for 30 minutes; obtaining finished plant extract for treating tonsillitis and pharyngolaryngitis;
through the operations, the obtained water extraction oral liquid of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea has obvious effect of treating tonsillitis and sphagitis.
Example 2:
s1, extracting immersion liquid: mixing 20 kg of achyranthes aspera, 12 kg of elsholtzia, 8 kg of Jianghua bitter tea and 400 liters of water, heating to 90 ℃, and extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.2 micron to obtain water extraction fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 70 ℃; then charging edible or medical oxygen into the water extraction fine filtration liquid, wherein the total dosage is 1.5 cubic meters under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the time from the beginning of oxygenation to the end of oxygenation is 110 minutes, and water extraction, fine filtration and oxidation liquid is obtained;
s4, sterilization: filling the oxidized water extraction fine filtration oxidation liquid into each 50 ml oral liquid bottle and screwing the cover tightly; placing the filled bottles into a sterilization cabinet, heating to 110 ℃ and sterilizing for 20 minutes; obtaining finished plant extract for treating tonsillitis and pharyngolaryngitis;
through the operations, the obtained water extraction oral liquid of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea has obvious effect of treating tonsillitis and sphagitis.
Example 3
S1, extracting immersion liquid: mixing 25 kg of radix cyathulae, 15 kg of elsholtzia, 10 kg of Jianghua bitter tea and 500 liters of water, heating to 95 ℃, and extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.25 micron to obtain water extraction fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 80 ℃; then filling edible or medical oxygen into the water extraction fine filtration liquid, wherein the total dosage is 2 cubic meters under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1200 liters per hour; the time from the beginning of oxygenation to the end of oxygenation is 150 minutes, and water extraction, fine filtration and oxidation liquid is obtained;
s4, sterilization: filling the oxidized water extraction fine filtration oxidation liquid into each 50 ml oral liquid bottle and screwing the cover tightly; placing the filled bottles into a sterilization cabinet, heating to 108 ℃ and sterilizing for 30 minutes; obtaining finished plant extract for treating tonsillitis and pharyngolaryngitis;
through the operations, the obtained water extraction oral liquid of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea has obvious effect of treating tonsillitis and sphagitis.
Example 4
S1, extracting immersion liquid: mixing and heating 20 kg of medicinal cyathula root, 12 kg of elsholtzia, 8 kg of Jianghua bitter tea and 400 liters of water to 90 ℃ and extracting for 90 minutes at constant temperature to obtain a water extract;
s2, filtering: filtering the water extract obtained in the step S1 through a filter membrane with the pore size of 0.2 micron to obtain water extraction fine filtrate;
s3, oxidation: heating the water extraction fine filtrate obtained in the step S2 to 70 ℃; then charging edible or medical oxygen into the water extraction fine filtration liquid, wherein the total dosage is 1.5 cubic meters under one atmosphere; in the process of oxygen filling, water extraction and fine filtration liquid is circulated from the inside to the outside of the tank and then to the inside of the tank by a pump, and the flow rate of the pump is controlled to be 1000 liters per hour; the time from the beginning of oxygenation to the end of oxygenation is 110 minutes, and water extraction, fine filtration and oxidation liquid is obtained;
s4, sterilization: filling the oxidized water extraction fine filtration oxidation liquid into each 50 ml oral liquid bottle and screwing the cover tightly; placing the filled bottles into a sterilization cabinet, heating to 110 ℃ and sterilizing for 20 minutes; obtaining finished plant extract for treating tonsillitis and pharyngolaryngitis;
through the operations, the obtained water extraction oral liquid of the medicinal cyathula root, the elsholtzia and the Jianghua bitter tea has obvious effect of treating tonsillitis and sphagitis.
Radix Cyathulae is also called radix Cyathulae, radix Achyranthis bidentatae, and is the dried root of radix Cyathulae of Amaranthaceae. Radix Cyathulae is sweet in taste, slightly bitter in taste and neutral in nature, enters liver and kidney meridians, has the effects of removing blood stasis and dredging meridians, easing joint movement, inducing diuresis and treating stranguria, and is used for treating amenorrhea and abdominal mass, retention of exocytosis, traumatic injury, rheumatic arthralgia, flaccidity of feet and muscle spasm, hematuria and stranguria;
achyranthes bidentata is the dry root of achyranthes bidentata of Amaranthaceae, has mild nature, bitter, sweet and sour taste, enters liver and kidney channels, and has the functions of nourishing liver and kidney, strengthening bones and muscles, inducing diuresis for treating stranguria and drawing blood downward; can be used for treating amenorrhea, dysmenorrhea, soreness of waist and knees, myasthenia of bones and muscles, stranguria, edema, headache, vertigo, toothache, aphtha, hematemesis, and epistaxis; modern pharmacological and clinical research shows that achyranthes bidentata has the effects of reducing blood pressure, improving liver function, enhancing humoral immunity, resisting inflammation and pain, promoting urination, relieving spasm, resisting aging and the like;
the achyranthes aspera is roots and rhizomes of achyranthes aspera, achyranthes bidentata wild species and achyranthes aspera of amaranthaceae, has the effects of activating blood circulation, dissipating blood stasis, clearing damp, inducing diuresis, clearing heat, removing toxicity and the like, is used for treating diseases such as gonorrhea, hematuria, amenorrhea of women, abdominal mass, rheumatic pain, pain in throb, dermatophytosis, edema, dysentery, malaria, diphtheria, carbuncle swelling, traumatic injury and the like in ancient Chinese medical science, is bitter and sour, is flat, is a ' Fojijian folk herbal medicine ' which is bitter, flat and nontoxic ' Guangxi Chinese herbal medicine ' which is slightly bitter and sour, cold in nature, nontoxic, is a ' Yunnan Chinese herbal medicine ' which is sweet and slightly sour, cool in heart, liver and large intestine meridians ', is treated by a modern product commonly used in traditional Chinese medicine, and has a clinically obvious effect;
herba Moslae is a vertical herbaceous plant belonging to Labiatae and Elsholtzia genus, and has dense fibrous root, stem usually branched from the middle part, blunt four-branched-in-one, with groove, no hair or soft hair, yellow straw, and purple brown color after aging; herba Moslae can induce sweat, relieve exterior syndrome, eliminate dampness, regulate the middle warmer, induce diuresis and alleviate edema; after being used as a medicine, the medicine can also promote lung qi to induce diuresis and reduce edema, has the similar effect as ephedra herb, has strong medicine efficacy, and is most suitable for treating yin cold block summer heat and wind-water edema, so the medicine is called as ephedra herb in summer; can be used for treating acute gastroenteritis, abdominal pain, emesis, diarrhea, summer-autumn heatstroke, headache, fever, aversion to cold, anidrosis, cholera, edema, epistaxis, halitosis, etc.;
the Jianghua bitter tea is used as a few large-leaf tea trees in Hunan province, and has red bright soup color, sweet, tasty and refreshing mouthfeel and no bitter.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention, and the scope of the present invention is defined by the appended claims, and all changes that come within the meaning and range of equivalency of the specification are therefore intended to be embraced therein.
Claims (8)
1. A preparation method of plant extract for treating tonsillitis and pharyngolaryngitis is characterized by comprising the following steps:
s1, extracting immersion liquid: mixing radix Cyathulae, herba Moslae, JIANGHUANWANGCHA, and water, and heating to obtain water extractive solution;
s2, filtering: filtering the water extract obtained in the step S1 by a filter membrane to remove impurities to obtain water extract fine filtrate;
s3, oxidation: charging edible or medical oxygen into the water extraction fine filtration liquid obtained in the step S2 to mix and oxidize to obtain water extraction fine filtration oxidation liquid;
s4, filling and sterilizing: and (5) filling the water-extracted fine-filtered oxidized liquid obtained in the step (S3) into an oral liquid bottle, and sterilizing at high temperature to obtain a finished product.
2. The method for preparing the plant extract for treating tonsillitis and pharyngolaryngitis according to claim 1, wherein the radix cyathulae extract of step S1 is: herba Moslae: jianghua bitter tea: the weight ratio of water is as follows: 3-5: 1-4: 1-3: 10-60, the heating extraction temperature is 80-100 ℃, and the extraction time is 40-150 minutes.
3. The method for preparing the plant extract for treating tonsillitis and pharyngolaryngitis according to claim 2, wherein said radix cyathulae is replaced by radix achyranthis bidentatae or radix achyranthis bidentatae.
4. The method as claimed in claim 1, wherein the impurities removed by the filtration in step S2 are substances larger than 0.25 μm, and the pore size of the filtration membrane used for the filtration is smaller than or equal to 0.25 μm.
5. The method for preparing the plant extract for treating tonsillitis and pharyngolaryngitis according to claim 1, wherein the oxidation time in step S3 is: 0.3-3.5 hours; the temperature is 60-95 ℃; in the process of mixed oxidation, circulating oxidation inside and outside the tank is carried out by a pump, and the circulation is carried out for 1 to 4 times per hour; the consumption of edible or medical oxygen is 1-9 cubic meters per ton of extract under one atmosphere.
6. The method for preparing the plant extract for treating tonsillitis and pharyngolaryngitis according to claim 1, wherein the temperature for sterilization in the filling and sterilizing process of step S4 is 104-128 ℃; the time is 10-90 minutes.
7. The method for preparing a plant extract for the treatment of tonsillitis and pharyngolaryngitis according to claim 1, wherein said oral liquid bottle in the filling and sterilizing of step S4 has a volume of 10-50 ml/bottle.
8. The plant extract for treating tonsillitis and pharyngolaryngitis according to any one of claims 1-7, having application in preparing traditional Chinese medicine for treating tonsillitis and pharyngolaryngitis.
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| CN111888455A (en) * | 2020-04-26 | 2020-11-06 | 任秀江 | Preparation method and application of plant extract for inhibiting xanthine oxidase activity |
| NL2032123B1 (en) * | 2022-06-10 | 2023-12-18 | Univ Gannan Medical | Mosla chinensis extract and application thereof |
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Application publication date: 20200519 |