CN1111419C - A kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof - Google Patents
A kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof Download PDFInfo
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- CN1111419C CN1111419C CN00110629A CN00110629A CN1111419C CN 1111419 C CN1111419 C CN 1111419C CN 00110629 A CN00110629 A CN 00110629A CN 00110629 A CN00110629 A CN 00110629A CN 1111419 C CN1111419 C CN 1111419C
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 206010008190 Cerebrovascular accident Diseases 0.000 title claims abstract description 30
- 208000006011 Stroke Diseases 0.000 title claims abstract description 30
- 208000024891 symptom Diseases 0.000 title claims abstract description 15
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 229960001126 alginic acid Drugs 0.000 claims abstract description 11
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 11
- 229920000615 alginic acid Polymers 0.000 claims abstract description 11
- 239000000783 alginic acid Substances 0.000 claims abstract description 11
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 11
- 241000218176 Corydalis Species 0.000 claims abstract description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 9
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 9
- 241000131808 Scolopendra Species 0.000 claims abstract description 9
- 210000000582 semen Anatomy 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 230000005070 ripening Effects 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 4
- 241000407170 Curcuma Species 0.000 claims description 8
- 235000014375 Curcuma Nutrition 0.000 claims description 8
- 241000219780 Pueraria Species 0.000 claims description 8
- 241000305492 Gastrodia Species 0.000 claims description 7
- 241000522620 Scorpio Species 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000009490 scorpio Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
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- 230000000694 effects Effects 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000005059 dormancy Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
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- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
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- 208000007107 Stomach Ulcer Diseases 0.000 description 1
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- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
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- 210000004351 coronary vessel Anatomy 0.000 description 1
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- 208000015238 neurotic disease Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 230000036280 sedation Effects 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000009692 xuesetong Substances 0.000 description 1
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Abstract
The invention discloses a kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof, it is that medicine such as to receive, stabilize with the two fat of Rhizoma Chuanxiong, Rhizoma Corydalis, JINCHONG, Rhizoma Gastrodiae, Radix Paeoniae Rubra, the Radix Aucklandiae, Semen Ziziphi Spinosae, Radix Curcumae, Rhizoma Acori Graminei, Scolopendra, Radix Salviae Miltiorrhizae, Radix Puerariae, Radix Notoginseng, alginic acid be raw material, prescription is prepared from through steps such as air-dry, pulverizing, ripening sterilization, mixing meticulously.Pharmaceutical formulation of the present invention and manufacture method uniqueness, therapeutic effect are remarkable.
Description
The present invention relates to medicine of section treatment cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof.
Cerebrovascular sclerosis causes apoplexy, the nervous headache that premonitory apoplexy symptom and various diseases cause, dizzy, tinnitus, deaf, cardiopalmus, uncomfortable in chest, breathe hard, insomnia, the few dormancy, hypomnesis, xerostomia, eye is done, dryness of the tongue, yellow and greasy fur, myasthenia of limbs, the mood fear, on tenterhooks, uneasy, dreary grief, nervous edema, two side of body distending pains, the chest pain side back of the body, the backache pleurobranch, ademosyne disease etc., these diseases all are the common frdquently encountered diseases of serious harm human health, at present, the total incidence of China is more than 50%, because these diseases are not come out with the Medical Instruments inspection, do not descend any diagnosis, the traditional Chinese medical science often is diagnosed as thanks to, and gas loses blood, deficiency of vital energy blood deficiency, suffer from a deficiency of the kidney, but the more satisfactory medicine of also readily good at present therapeutic effect, BUCHANG NAOXINTONG, DIAOXINXUE KANG, arklemin closes readily good strongly fragrant and sedations such as ball, there is not blood fat reducing yet, blood viscosity, expand microcirculatory effect, Radix Salviae Miltiorrhizae, though XUESAITONG has certain effect to blood viscosity lowering, curative effect can not be lasting.
The objective of the invention is to provide a kind of and have blood viscosity lowering, alleviate intracranial pressure, microcirculation improvement, prevention ademosyne state, alleviate the cardiovascular and cerebrovascular vessel spasm, reduce the downright bad effect of cerebrovascular, have no side effect, the treatment cardiovascular and cerebrovascular vessel apoplexy of taking convenience and medicine of premonitory apoplexy symptom and preparation method thereof.
Solution of the present invention is based on pathogenetic understanding and the Therapeutic Principle of the traditional Chinese medical science to above-mentioned two kinds of diseases, the Western medicine of choosing during with reference to western medical treatment, and simultaneously according to my clinical experience for many years, prescription is formulated meticulously.
Medicine of the present invention is the medicament of being made by the following weight proportion raw material:
10～40 parts in 10～40 parts of Rhizoma Gastrodiaes of 10～40 parts of Scorpio of 10～40 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
10～40 parts of 10～40 portions of Radix Curcumaes of 1 0～40 parts of Semen Ziziphi Spinosaes of 10～40 parts of Radix Aucklandiae of Radix Paeoniae Rubra
10～40 parts of 10～40 parts of Radix Puerariaes of 1.5～6 Radix Salviae Miltiorrhizaes of 10～40 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 10～40 parts of alginic acid of Radix Notoginseng are received 1～4 part stable 0.025～0.1 part
The preferred weight proportioning of making pharmaceutical formulation of the present invention is:
15～25 parts in 15～25 parts of Rhizoma Gastrodiaes of 15～25 parts of Scorpio of 15～25 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
15～25 parts of 15～25 portions of Radix Curcumaes of 15～25 parts of Semen Ziziphi Spinosaes of 15～25 parts of Radix Aucklandiae of Radix Paeoniae Rubra
15～25 parts of 15～25 parts of Radix Puerariaes of 2.5～3.75 Radix Salviae Miltiorrhizaes of 15～25 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 15～25 parts of alginic acid of Radix Notoginseng are received 1.5～2.5 parts stable 0.0375～0.0625 part
The optimum weight proportioning of pharmaceutical formulation of the present invention is:
20 parts in 20 parts of Rhizoma Gastrodiaes of 20 parts of Scorpio of 20 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
20 parts of 20 portions of Radix Curcumaes of 20 parts of Semen Ziziphi Spinosaes of 20 parts of Radix Aucklandiae of Radix Paeoniae Rubra
20 parts of 20 parts of Radix Puerariaes of 3 Radix Salviae Miltiorrhizaes of 20 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 20 parts of alginic acid of Radix Notoginseng are received 2 parts stable 0.05 part
Above-mentioned component is made medicine production method of the present invention is:
1, the two fat of alginic acid of choosing formula ratio are received, are stabilized and mix;
2, the air-dry 120 order fine powders that are ground into of all the other medicines in will filling a prescription are placed on and carried out the ripening sterilization treatment under 100～110 ℃ 30 minutes;
3, after the cooling all medicament mixed are made powder, also can incapsulate.
Pharmaceutical formulation of the present invention can be made into any medically said dosage form.
Medicine of the present invention has following advantage through the clinical observation proof:
1, medicine of the present invention nontoxic to human body, have no side effect;
2, medicine of the present invention need not decoct, taking convenience;
3, for determining the therapeutic effect of medicine of the present invention to cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom, the inventor is according to inside and outside woman's disease diagnosis efficacy criteria of in October, 1998 Department of Medical Administration of State Administration of Traditional Chinese Medicine issue, the patient who suffers from apoplexy sequela, premonitory apoplexy symptom, cardiovascular and cerebrovascular vessel, coronary heart disease, nervous headache, insomnia, few dormancy, cardio palmus shape has been carried out clinical observation, and the result is as follows:
Treatment 14442 examples are observed in outpatient service;
Treatment 135 examples are hospitalized for observation;
Add up to 14577 examples.
One, the treatment of premonitory apoplexy symptom was a course of treatment in ten days, treated 5337 examples altogether general 3～5 courses of treatment, cured 5216 examples, effective 121 examples, effective percentage 100%.
Two, apoplexy sequela is treated 233 examples altogether, and 135 examples are cured, and 98 examples are effective, effective percentage 100%.
Three, cerebrovascular neuralgia 3598 examples are cured 3469 examples, effective 129 examples, cure rate 100%.
Four, neurasthenia, insomnia or hypersomnia are treated 1542 examples, cure 1465 examples, effective 77 examples, effective percentage 100%.
Five, gastric ulcer, gastritis, stomach neurosis are treated 257 examples, cure 246 examples, effective 11 examples, effective percentage 100%.
Six, hepatopathy causes that the nervous system syndrome treats 56 examples, cures 51 examples, effective 5 examples, effective percentage 100%.
Seven, diabetes cause cardio-cerebral vascular nervous system disease treatment 116 examples, cure 98 examples, effective 18 examples, effective percentage 100%.
Eight, coronary heart disease 1236 examples are cured 1125 examples, effective 111 examples, effective percentage 100%.
Nine, hyperthyroidism 98 examples are cured 89 examples, effective 9 examples, effective percentage 100%.
Ten, cause cardio-cerebral vascular nervous system disease treatment 49 examples behind the various surgical operations, cure 46 examples, effective 3 examples, effective percentage 100%.
11, anemia causes that neurological symptom treats 98 examples, cures 91 examples, effective 7 examples, effective percentage 100%.
12, various difficult miscellaneous diseases 172 examples are cured 169 examples, effective 3 examples, effective percentage 100%.
13, cervical spondylosis causes nervous system syndrome 1785 examples, cures effective 16 examples of 1769 examples, effective percentage 100%.
More than 13 kinds of treatment for diseases cure 13969 examples, cure rate is 95.83%, effective 608 examples, total effective rate 100%.
Specify embodiment below:
Choose medicine at first in proportion:
Rhizoma Chuanxiong 25 gram Rhizoma Corydalis 25 gram Scorpio 25 gram Rhizoma Gastrodiaes 25 gram Radix Paeoniae Rubra 25 grams
1.5 of the Radix Aucklandiae 25 gram Semen Ziziphi Spinosaes 25 gram Radix Curcumaes 25 gram Rhizoma Acori Graminei 25 gram Scolopendras
The two fat of Radix Salviae Miltiorrhizae 25 gram Radix Puerariaes 25 gram Radix Notoginseng, 25 gram alginic acid are received stable 0.0625 gram of 2.5 grams
The two fat of alginic acid are received mix with stabilizing; With the air-dry 120 order fine powders that are ground into of all the other medicines, be placed on and carried out the ripening sterilization treatment under 100～110 ℃ 30 minutes; After the cooling all medicament mixed are made powder.During use, each 10 grams, every day 2 times, one after each meal.
Claims (6)
1, a kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom is characterized in that it is the medicament of being made by the following weight proportion raw material:
10～40 parts in 10～40 parts of Rhizoma Gastrodiaes of 10～40 parts of Scorpio of 10～40 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
10～40 parts of 10～40 portions of Radix Curcumaes of 10～40 parts of Semen Ziziphi Spinosaes of 10～40 parts of Radix Aucklandiae of Radix Paeoniae Rubra
10～40 parts of 10～40 parts of Radix Puerariaes of 1.5～6 Radix Salviae Miltiorrhizaes of 10～40 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 10～40 parts of alginic acid of Radix Notoginseng are received 1～4 part stable 0.025～0.1 part
2, a kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
15～25 parts in 15～25 parts of Rhizoma Gastrodiaes of 15～25 parts of JINCHONG of 15～25 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
15～25 parts of 15～25 portions of Radix Curcumaes of 15～25 parts of Semen Ziziphi Spinosaes of 15～25 parts of Radix Aucklandiae of Radix Paeoniae Rubra
15～25 parts of 15～25 parts of Radix Puerariaes of 2.25～3.75 Radix Salviae Miltiorrhizaes of 15～25 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 15～25 parts of alginic acid of Radix Notoginseng are received 1.5～2.5 parts stable 0.0375～0.0625 part
3, a kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom according to claim 1. it is characterized in that wherein the weight proportion of each raw material is:
20 parts in 20 parts of Rhizoma Gastrodiaes of 20 parts of Scorpio of 20 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
20 parts of 20 portions of Radix Curcumaes of 20 parts of Semen Ziziphi Spinosaes of 20 parts of Radix Aucklandiae of Radix Paeoniae Rubra
20 parts of 20 parts of Radix Puerariaes of 1.5～6 Radix Salviae Miltiorrhizaes of 20 parts of Scolopendras of Rhizoma Acori Graminei
The two fat of 20 parts of alginic acid of Radix Notoginseng are received 2 parts stable 0.05 part
4, according to claim 1,2 or 3 described a kind of medicines for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom, it is characterized in that: described medicament is a said dosage form on any pharmaceutics.
5, a kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom according to claim 4 is characterized in that described medicament is powder or capsule.
6, the preparation method of the medicine of a kind of apoplexy and premonitory apoplexy symptom is characterized in that: choose the two fat of alginic acid and receive 1～4 part, stable 0.025～0.1 part of mixing; With 10～40 parts of Rhizoma Chuanxiongs, 10～40 parts of Rhizoma Corydalis, 10～40 parts of Scorpio, 10～40 parts in Rhizoma Gastrodiae, 10～40 parts of Radix Paeoniae Rubra, 10～40 parts of the Radix Aucklandiae, 10～40 parts of Semen Ziziphi Spinosaes, 10～40 parts of Radix Curcumaes, 10～40 parts of Rhizoma Acori Graminei, 1.5～6 of Scolopendras, 10～40 parts of Radix Salviae Miltiorrhizaes, 10～40 parts of Radix Puerariaes, 10～40 parts of air-dry 120 order fine powders that are ground into of Radix Notoginseng are placed on and carried out the ripening sterilization treatment under 100～110 ℃ 30 minutes; After the cooling all medicament mixed are made powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00110629A CN1111419C (en) | 2000-07-05 | 2000-07-05 | A kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00110629A CN1111419C (en) | 2000-07-05 | 2000-07-05 | A kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1283473A CN1283473A (en) | 2001-02-14 |
| CN1111419C true CN1111419C (en) | 2003-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN00110629A Expired - Fee Related CN1111419C (en) | 2000-07-05 | 2000-07-05 | A kind of medicine for the treatment of cardiovascular and cerebrovascular vessel apoplexy and premonitory apoplexy symptom and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102423443B (en) * | 2011-12-27 | 2014-08-06 | 峨眉山天梁星制药有限公司 | Double-formula medicine used for treating insomnia, and preparation method thereof |
| CN105169107A (en) * | 2015-10-19 | 2015-12-23 | 吉林大学 | Anti-depression dispersible traditional Chinese medicine tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171248A (en) * | 1996-07-22 | 1998-01-28 | 赵广钧 | Chinese medicine capsule for treating apoplexy |
| CN1186429A (en) * | 1995-06-07 | 1998-07-01 | R·P·谢勒公司 | Process and composition for preparing soft gelatin capsules resistant to penetration of filler into shell |
-
2000
- 2000-07-05 CN CN00110629A patent/CN1111419C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186429A (en) * | 1995-06-07 | 1998-07-01 | R·P·谢勒公司 | Process and composition for preparing soft gelatin capsules resistant to penetration of filler into shell |
| CN1171248A (en) * | 1996-07-22 | 1998-01-28 | 赵广钧 | Chinese medicine capsule for treating apoplexy |
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| CN1283473A (en) | 2001-02-14 |
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