CN111134127A - Enconazole spray for poultry houses and preparation method thereof - Google Patents
Enconazole spray for poultry houses and preparation method thereof Download PDFInfo
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- CN111134127A CN111134127A CN201911368887.9A CN201911368887A CN111134127A CN 111134127 A CN111134127 A CN 111134127A CN 201911368887 A CN201911368887 A CN 201911368887A CN 111134127 A CN111134127 A CN 111134127A
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- spray
- enoconazole
- poultry
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- enilconazole
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- 244000144977 poultry Species 0.000 title claims abstract description 63
- 239000007921 spray Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims description 14
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 28
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 28
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 19
- PZBPKYOVPCNPJY-UHFFFAOYSA-N 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=C)CN1C=NC=C1 PZBPKYOVPCNPJY-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000005795 Imazalil Substances 0.000 claims abstract description 18
- 229960002125 enilconazole Drugs 0.000 claims abstract description 18
- 229940073499 decyl glucoside Drugs 0.000 claims abstract description 16
- -1 octyl decyl Chemical group 0.000 claims abstract description 16
- 239000003960 organic solvent Substances 0.000 claims abstract description 13
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims description 22
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 19
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- 230000003078 antioxidant effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
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- 229930182478 glucoside Natural products 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 2
- 241001122767 Theaceae Species 0.000 claims description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 2
- 235000013824 polyphenols Nutrition 0.000 claims description 2
- 235000010388 propyl gallate Nutrition 0.000 claims description 2
- 239000000473 propyl gallate Substances 0.000 claims description 2
- 229940075579 propyl gallate Drugs 0.000 claims description 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 2
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- 239000003899 bactericide agent Substances 0.000 abstract description 2
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- 235000013594 poultry meat Nutrition 0.000 description 52
- 239000000645 desinfectant Substances 0.000 description 8
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- 230000001965 increasing effect Effects 0.000 description 7
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
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- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 201000002909 Aspergillosis Diseases 0.000 description 3
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- 241000894006 Bacteria Species 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
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- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 description 1
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- 239000004902 Softening Agent Substances 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
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- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
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- 235000013622 meat product Nutrition 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an enilconazole spray for poultry houses, which can effectively kill mould spores in the air of the poultry houses and prevent and treat various mycotic diseases. In the invention, the enilconazole is a systemic bactericide, can effectively kill common aspergillus fumigatus and aspergillus flavus in poultry houses, and can prevent and treat mycotic diseases; the octyl decyl glucoside can effectively increase the stability of a solution system, and can effectively enable the enilconazole drug molecules to be combined with mould spores in the air and increase the surface permeability of the spores when in use due to the lipophilic and hydrophilic characteristics of the octyl decyl glucoside; the water-soluble azone is used as a penetration enhancer, and can effectively promote the diffusion of the eniconazole drug molecules in the air particles; the enoconazole spray for the poultry house also comprises polyethylene glycol which is used as an organic solvent, can effectively dissolve the enoconazole raw material, and a plurality of components supplement each other to form a stable solution system to play a role together.
Description
Technical Field
The invention belongs to the field of livestock breeding, and particularly relates to an enoconazole spray for a poultry house and a preparation method thereof.
Background
Among the various meat products, poultry products are an important class of everyday food products. Since the 80's of the 20 th century, the poultry industry has kept a good growth trend, and poultry meat has now become the second largest consumer of meat in the world instead of beef. Poultry farming has been in our country for over 5000 years. The poultry industry in China has been rapidly developed since the reform and the opening, and the poultry feeding quantity and the poultry egg yield are continuously maintained for years in the world first and the poultry meat yield in the world second. In the last half of 2019, the poultry yield in China is 952 ten thousand tons, which is increased by 50 thousand tons and increased by 5.6%; the yield of the poultry eggs is 1516 ten thousand tons, the yield is increased by 53 ten thousand tons, and the yield is increased by 3.6 percent. Domestic poultry varieties have abundant resources and different characteristics, and are closely related to the lives of people in China. Poultry industry is the fundamental industry of animal husbandry in China, and poultry meat and eggs are also the main sources of protein consumption of urban and rural residents in China. Along with the social development, the functions of poultry industry such as cultural value, entertainment value, ecological value, popular science propaganda and education and the like are also highlighted. The development of the poultry industry has very important significance for accelerating the construction of modern animal husbandry, promoting the strategic adjustment of agricultural structures, improving the quality and level of life of people and increasing the income of farmers.
In the process of poultry farming, aspergillosis is a very common fungal disease. The main pathogeny causing the poultry aspergillosis is aspergillus fumigatus and aspergillus flavus, the disease can occur all the year round, the disease is the most serious in 6-11 months, and the growth of the poultry is seriously influenced. The most direct reason for aspergillosis is that a large amount of mould spores are in the air of a poultry house, the quantity of dust contained in the air of the poultry house is large due to poor ventilation and overlarge feeding density, so that the mould spores float in the air and infect poultry through respiratory tracts and drinking water, and the temperature and the humidity of the poultry house are favorable for the propagation of the mould, so that the disease is induced more easily. Mycoses can cause a number of problems in poultry farming, such as: causing atrophy of immune organs such as bursa of Fabricius, thymus and spleen, and inducing immunosuppression; causing frequent diarrhea, the intestinal tract disease is not cured for a long time, and the food intake is greatly reduced; disruption of the digestive tract, causing canker sores, crop inflammation and proliferative adenitis; causing liver multifocal hepatocyte necrosis, and causing problems of canaliculus inflammation and gallbladder brittleness increase; the laying of the breeding poultry is reduced, the quality of the eggshell is reduced, the fertility rate and the hatching rate are reduced, and the dead embryo rate is increased; damage to the kidney, obstruction of the tubules by deformation, and production of urate deposits, leading to an increase in leg disease of unknown etiology. The disinfectant commonly used in the poultry houses is usually glutaraldehyde, formaldehyde, an iodine preparation, a chlorine preparation, a quaternary ammonium salt and the like, and the disinfectant has wide use and good disinfection effect, but can only kill bacteria and viruses on the surfaces of objects, and has undesirable effect on killing mold on the surfaces of the objects. The formaldehyde fumigation method commonly used in poultry houses for air disinfection can inhibit the transmission of some pathogenic bacteria, but also can cause harm to poultry and even people, and cannot disinfect mould spores in the air. Therefore, there is a need for a disinfectant that can directly and effectively kill the mold spores in the air of poultry houses.
Disclosure of Invention
In view of the above, the invention provides a spray capable of effectively killing mold spores in air of poultry houses
In one aspect, the invention provides an enoconazole spray for an aviary, which comprises the following components of enoconazole, octyl decyl glucoside, water-soluble azone and water.
On the basis of the above technical scheme, preferably, the organic solvent further comprises at least one of polyethylene glycol and propylene glycol.
Further preferably, the composition further comprises an antioxidant.
Further preferably, the antioxidant comprises at least one of dibutyl hydroxy toluene, ascorbyl palmitate, butyl hydroxy anisole, tert-butyl hydroquinone, propyl gallate, sodium bisulfite and tea polyphenols.
More preferably, the molecular weight of the polyethylene glycol is 200 to 600.
Further preferably, the mass percentages of the components are as follows: 0.05-0.5% of enilconazole, 0.1-2% of octyl decyl glucoside, 30-45% of organic solvent, 0.01-0.1% of antioxidant and the balance of water.
On the other hand, the invention also provides a preparation method of the enoconazole spray for the poultry house, which comprises the following steps:
s1, adding enilconazole into the organic solvent, and uniformly stirring to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring uniformly to obtain a second solution, adding the first solution into the second solution, and adding an antioxidant to obtain the spray.
On the basis of the technical scheme, at least one of organic solvents of polyethylene glycol and propylene glycol is preferable.
On the basis of the technical scheme, the antioxidant is preferably dibutyl hydroxy toluene.
Further preferably, the polyethylene glycol has a molecular weight of 400.
Compared with the prior art, the enoconazole spray for the poultry house has the following beneficial effects:
(1) the enoconazole spray for the poultry house can effectively kill mould spores in the air of the poultry house and prevent and treat various mycotic diseases. In the invention, the enilconazole is a systemic bactericide, can effectively kill common aspergillus fumigatus and aspergillus flavus in poultry houses, and can prevent and treat mycotic diseases; the octyl decyl glucoside can effectively increase the stability of a solution system, and can effectively enable the enilconazole drug molecules to be combined with mould spores in the air and increase the surface permeability of the spores when in use due to the lipophilic and hydrophilic characteristics of the octyl decyl glucoside; the water-soluble azone is used as a penetration enhancer, and can effectively promote the diffusion of the eniconazole drug molecules in the air particles; the enoconazole spray for the poultry house also comprises polyethylene glycol which is used as an organic solvent, can effectively dissolve the enoconazole raw material, and a plurality of components supplement each other to form a stable solution system to play a role together.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
An enoconazole spray for poultry houses comprises the following raw materials: 0.2kg of enilconazole, 1kg of octecyl glucoside, 38kg of polyethylene glycol, 2.5kg of water-soluble azone, 0.05kg of dibutylhydroxytoluene and 58.25kg of water; wherein the molecular weight of the polyethylene glycol is 400.
The preparation method of the enoconazole spray for the poultry house comprises the following steps:
s1, adding eniconazole into polyethylene glycol, and stirring until the eniconazole is completely dissolved to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring and mixing uniformly to obtain a second solution, adding the first solution into the second solution, adding dibutyl hydroxy toluene, and stirring until the dibutyl hydroxy toluene is completely dissolved to obtain the enoconazole spray for the poultry house.
Enconazole (C) in the invention14H14Cl2N2O) also known as imazalil, chemically 1- [2- (2, 4-dichlorophenyl) -2- (2-allyloxy) ethyl]-1H-imidazole, a systemic benzimidazole fungicide, with the characteristics of high efficiency, broad spectrum and low toxicity. The enoconazole is slightly soluble in water and easily soluble in an organic solvent, and is mainly used as a local antibacterial medicament on veterinary medicines. The invention selects the spray prepared from the enilconazole, not only can effectively kill the mould on the surfaces of cages, instruments and the like, but also has good killing effect on mould spores in the air. The octyl decyl glucoside is an acid and alkali resistant nonionic surfactant, is easy to dissolve in water and common organic solventsThe agent has excellent decontamination, dispersion, emulsification, solubilization, wetting, penetration, foaming, foam stabilization and other performances. The octyl decyl glucoside disclosed by the invention has the advantages that on one hand, the stability of the whole solution system is increased, and the raw material of the water-insoluble enoconazole is prevented from being separated out; on the other hand, the enoconazole gel has two characteristics of lipophilicity and hydrophilicity, so that the enoconazole gel can be quickly adhered to the surface of the mould spores when in use, and the enoconazole drug molecules directly act with the mould spores. The polyethylene glycol is a nontoxic and nonirritating organic solvent, has good water solubility, and has good intermiscibility with a plurality of organic matter components. Polyethylene glycol has excellent lubricity, moisture retention, dispersibility, adhesive, antistatic agent, softening agent and the like. The polyethylene glycol can be used as an organic solvent to effectively dissolve the eniconazole, and the eniconazole still keeps stable and has no precipitate after being mixed with water. The water-soluble azone is a water-soluble product modified by oil-soluble azone, and has obvious permeation-aiding effect on lipophilic and hydrophilic medicines and active ingredients. The water-soluble azone can increase the mobility of the Enconazole drug molecules and particles in the air, so that the diffusion resistance of the drug in the air is reduced, and a strong permeation promoting effect is achieved. The dibutyl hydroxy toluene is one of the most common antioxidants, and has the characteristics of good stability, strong oxidation resistance, no influence on oxidation resistance when heated, safety, no toxicity and the like. The anti-oxidation effect of the dibutyl hydroxy toluene is realized because of the autoxidation of the dibutyl hydroxy toluene, and the invention can well increase the stability of the whole solution system and prolong the shelf life.
Example 2
An enoconazole spray for poultry houses comprises the following raw materials: 0.1kg of enilconazole, 1.5kg of octadecyldlucoside, 35kg of polyethylene glycol, 1.5kg of water-soluble azone, 0.025kg of dibutylhydroxytoluene and 61.875kg of water; wherein the molecular weight of the polyethylene glycol is 400.
The preparation method of the enoconazole spray for the poultry house comprises the following steps:
s1, adding eniconazole into polyethylene glycol, and stirring until the eniconazole is completely dissolved to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring and mixing uniformly to obtain a second solution, adding the first solution into the second solution, adding dibutyl hydroxy toluene, and stirring until the dibutyl hydroxy toluene is completely dissolved to obtain the enoconazole spray for the poultry house.
Example 3
An enoconazole spray for poultry houses comprises the following raw materials: 0.05kg of enilconazole, 0.1kg of octadecyldlucoside, 30kg of polyethylene glycol, 1kg of water-soluble azone, 0.01kg of dibutylhydroxytoluene and 68.84kg of water; wherein the molecular weight of the polyethylene glycol is 400.
The preparation method of the enoconazole spray for the poultry house comprises the following steps:
s1, adding eniconazole into polyethylene glycol, and stirring until the eniconazole is completely dissolved to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring and mixing uniformly to obtain a second solution, adding the first solution into the second solution, adding dibutyl hydroxy toluene, and stirring until the dibutyl hydroxy toluene is completely dissolved to obtain the enoconazole spray for the poultry house.
Example 4
An enoconazole spray for poultry houses comprises the following raw materials: 0.5kg of enilconazole, 2kg of octecyl glucoside, 45kg of polyethylene glycol, 4kg of water-soluble azone, 0.1kg of dibutylhydroxytoluene and 48.4kg of water; wherein the molecular weight of the polyethylene glycol is 400.
The preparation method of the enoconazole spray for the poultry house comprises the following steps:
s1, adding eniconazole into polyethylene glycol, and stirring until the eniconazole is completely dissolved to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring and mixing uniformly to obtain a second solution, adding the first solution into the second solution, adding dibutyl hydroxy toluene, and stirring until the dibutyl hydroxy toluene is completely dissolved to obtain the enoconazole spray for the poultry house.
Example 5
An enoconazole spray for poultry houses comprises the following raw materials: 0.35kg of enilconazole, 1.8kg of octadecyldlucoside, 40kg of polyethylene glycol, 3kg of water-soluble azone, 0.075kg of dibutylhydroxytoluene and 54.775kg of water; wherein the molecular weight of the polyethylene glycol is 400.
The preparation method of the enoconazole spray for the poultry house comprises the following steps:
s1, adding eniconazole into polyethylene glycol, and stirring until the eniconazole is completely dissolved to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring and mixing uniformly to obtain a second solution, adding the first solution into the second solution, adding dibutyl hydroxy toluene, and stirring until the dibutyl hydroxy toluene is completely dissolved to obtain the enoconazole spray for the poultry house.
The spray prepared in example 1 was used in a chicken farm in the city of Hubei province. Two adjacent chick barns are selected, the area of each chick barns is about 30 square meters and the height of each chick barns is about 4 meters, the spray prepared in the embodiment 1 and a 10% glutaraldehyde solution are respectively used for spray disinfection, air sampling is carried out on the chick barns in the corresponding chick barns 20min before spraying, 30min after spraying, 60min, 90min and 120min after spraying, spores in sampled air are observed under a microscope, the comparison disinfection effect of the number of the spores is calculated, and the experimental results are shown in the following table 1.
TABLE 1 disinfectant effect of sprays of the invention with glutaraldehyde solutions
| Example 1 (number of spores/m)3) | 10% glutaraldehyde solution (number of spores/m)3) | |
| Sampling 20min before spraying | 1.9×109 | 1.8×109 |
| Sampling 30min after spraying | 6.9×108 | 1.3×109 |
| Sampling 60min after spraying | 8.7×107 | 0.7×109 |
| Sampling 90min after spraying | 1.8×107 | 0.3×109 |
| Sampling 120min after spraying | 7.4×106 | 9.8×108 |
The disinfectants commonly used in poultry houses are usually glutaraldehyde, iodine preparations, chlorine preparations, quaternary ammonium salts and the like, have different degrees of killing effects on bacteria, viruses and the like, and are widely used in poultry breeding. However, these conventional disinfectants have a poor effect of killing mold, and do not have a sterilizing effect particularly on mold spores (particularly aspergillus fumigatus spores) suspended in air. The spray of the invention is convenient to use, and can be directly sprayed on the surface of an object and in the air by using a spray can or a high-pressure water gun. Compared with the traditional disinfectant, the spray of the invention has good stability, quick effect and long action time, can effectively kill various moulds and spores thereof in poultry houses, effectively reduces the morbidity of various mycotic diseases, and has safe and nontoxic use dosage and low use cost. As can be seen from Table 1, the spray of the present invention can effectively kill spores in air of poultry houses and continuously act compared with the conventional glutaraldehyde disinfectant.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. An enilconazole spray for poultry houses is characterized in that: comprises the following components: eniconazole, octecyl glucoside, water-soluble azone and water.
2. An enoconazole spray for poultry houses as claimed in claim 1, which is characterized in that: the organic solvent comprises at least one of polyethylene glycol and propylene glycol.
3. An enoconazole spray for poultry houses as claimed in claim 2, characterized in that: also comprises an antioxidant.
4. An enoconazole spray for poultry houses as claimed in claim 3, which is characterized in that: the antioxidant comprises at least one of dibutyl hydroxy toluene, ascorbyl palmitate, butyl hydroxy anisole, tert-butyl hydroquinone, propyl gallate, sodium bisulfite and tea polyphenol.
5. An enoconazole spray for poultry houses as claimed in claim 2, characterized in that: the molecular weight of the polyethylene glycol is 200-600.
6. The enoconazole spray for poultry houses as claimed in claim 4, wherein: the weight percentage of each component is as follows: 0.05-0.5% of enilconazole, 0.1-2% of octyl decyl glucoside, 30-45% of organic solvent, 0.01-0.1% of antioxidant and the balance of water.
7. A preparation method of an enilconazole spray for an aviary is characterized in that: the method comprises the following steps:
s1, adding enilconazole into the organic solvent, and uniformly stirring to obtain a first solution;
s2, adding octyl decyl glucoside and water-soluble azone into water, stirring uniformly to obtain a second solution, adding the first solution into the second solution, and adding an antioxidant to obtain the spray.
8. The method for preparing the enoconazole spray for the poultry house as claimed in claim 7, wherein: at least one of polyethylene glycol and propylene glycol as organic solvent.
9. The method for preparing the enoconazole spray for the poultry house as claimed in claim 7, wherein: the antioxidant is dibutyl hydroxy toluene.
10. The method for preparing the enoconazole spray for the poultry house as claimed in claim 8, characterized in that: the molecular weight of the polyethylene glycol is 400.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112656907A (en) * | 2020-12-23 | 2021-04-16 | 武汉川泰科技有限公司 | External liquid preparation for treating pet fungal dermatosis |
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