CN111117812B - Environment-friendly sterilization composition and preparation method thereof - Google Patents
Environment-friendly sterilization composition and preparation method thereof Download PDFInfo
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- CN111117812B CN111117812B CN202010018096.XA CN202010018096A CN111117812B CN 111117812 B CN111117812 B CN 111117812B CN 202010018096 A CN202010018096 A CN 202010018096A CN 111117812 B CN111117812 B CN 111117812B
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 17
- 150000001298 alcohols Chemical class 0.000 claims abstract description 17
- 150000003862 amino acid derivatives Chemical class 0.000 claims abstract description 16
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 11
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 57
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 claims description 38
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 31
- 229960004063 propylene glycol Drugs 0.000 claims description 21
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 17
- 229930195725 Mannitol Natural products 0.000 claims description 17
- 239000000594 mannitol Substances 0.000 claims description 17
- 235000010355 mannitol Nutrition 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000003755 preservative agent Substances 0.000 claims description 13
- 230000002335 preservative effect Effects 0.000 claims description 13
- UYTOHYBIBPDOKX-ZDUSSCGKSA-N (2s)-2-(dodecanoylamino)propanoic acid Chemical group CCCCCCCCCCCC(=O)N[C@@H](C)C(O)=O UYTOHYBIBPDOKX-ZDUSSCGKSA-N 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 11
- 235000013772 propylene glycol Nutrition 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
- 239000012459 cleaning agent Substances 0.000 abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 27
- 239000000047 product Substances 0.000 description 9
- 239000004744 fabric Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 230000002070 germicidal effect Effects 0.000 description 7
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 5
- 235000010234 sodium benzoate Nutrition 0.000 description 5
- 239000004299 sodium benzoate Substances 0.000 description 5
- 244000178870 Lavandula angustifolia Species 0.000 description 4
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000005202 decontamination Methods 0.000 description 4
- 230000003588 decontaminative effect Effects 0.000 description 4
- 239000001102 lavandula vera Substances 0.000 description 4
- 235000018219 lavender Nutrition 0.000 description 4
- 229940034008 mannitol / sorbitol Drugs 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- LSBAZFASKHLHKB-LJQANCHMSA-N (2r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(1,3-thiazol-4-yl)propanoic acid Chemical compound C([C@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C1=CSC=N1 LSBAZFASKHLHKB-LJQANCHMSA-N 0.000 description 2
- ZGNLFUXWZJGETL-YUSKDDKASA-N (Z)-[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium Chemical compound N[C@@H](C\[N+]([O-])=N\O)C(O)=O ZGNLFUXWZJGETL-YUSKDDKASA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000005108 dry cleaning Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical group C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 1
- 239000004247 glycine and its sodium salt Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229940029258 sodium glycinate Drugs 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of cleaning agents, and particularly provides an environment-friendly sterilization composition and a preparation method thereof. The invention provides an environment-friendly bactericidal composition, which comprises, by weight, at least 0.1-5 parts of amino acid derivatives, 2-10 parts of alcohols, 2-10 parts of fatty alcohol-polyoxyethylene ether and 0.1-10 parts of builders.
Description
Technical Field
The invention relates to the technical field of cleaning agents, and particularly provides an environment-friendly sterilization composition and a preparation method thereof.
Background
Along with the development of society, the living standard of people is increasingly improved, the quality requirement on life is higher and higher, people pay more and more attention to how to easily and quickly remove stains and bacteria on various clothes such as down jackets, sweaters, curtains and the like and various household articles without leaving marks, and many washing articles sold on the market are usually cleaned aiming at certain type of articles, have single effect and unsatisfactory effect, have high labor intensity and long time spent in the using process, and have unsatisfactory actual using effect.
In addition, many dry cleaning agents and detergents that are commercially available have a bactericidal function, but many of these products use an oxidation bleaching agent and are sterilized by active oxygen. However, active oxygen is a strong oxidizing agent and has a harmful effect on various articles, and many products have problems such as low stability and poor detergency.
Disclosure of Invention
In order to solve the technical problems, the invention provides an environment-friendly sterilization composition in a first aspect, which comprises, by weight, at least 0.1-5 parts of amino acid derivatives, 2-10 parts of alcohols, 2-10 parts of fatty alcohol-polyoxyethylene ether, and 0.1-10 parts of builders.
In a preferred embodiment of the present invention, the alcohol includes 1, 2-propanediol.
In a preferred embodiment of the present invention, the alcohol further comprises mannitol or sorbitol.
As a preferable technical scheme of the invention, the weight ratio of the 1, 2-propylene glycol to the mannitol or the sorbitol is (6-9): 1.
as a preferred embodiment of the present invention, the builder comprises guanidinoacetic acid.
As a preferred embodiment of the present invention, the builder further comprises citric acid.
As a preferable technical scheme of the invention, the weight ratio of the guanidinoacetic acid to the citric acid is 1: (4.8-5.8).
As a preferable technical scheme, the preparation raw materials further comprise 0.05-0.2 part by weight of preservative.
As a preferred embodiment of the present invention, the weight ratio of the builder to the alcohol is 1: (1-2).
The second aspect of the invention provides a preparation method of the environment-friendly sterilization composition, which at least comprises the following steps: adding the components into a mixer, and stirring and mixing uniformly to obtain the product.
Has the advantages that: the invention provides an environment-friendly bactericidal composition, supramolecular amino acid is used as an amino acid type surfactant, and the cleaning capability is strong; specific alcohol substances and builders are added, and the composition with good appearance state and high stability is prepared by controlling the content, so that the storage requirements of products in different environments can be met; the composition contains a surfactant with low foam and strong permeability, and has remarkable decontamination and sterilization effects; the composition has the function of sterilization, high biodegradation degree, no pollution to the environment and environmental protection. The composition has simple preparation process, can be used in various cleaning products, and has high economic benefit and social benefit.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the invention provides an environment-friendly sterilization composition in a first aspect, which comprises, by weight, at least 0.1-5 parts of amino acid derivatives, 2-10 parts of alcohols, 2-10 parts of fatty alcohol-polyoxyethylene ether, and 0.1-10 parts of builders.
In a preferred embodiment, the environment-friendly sterilization composition is prepared from at least 2.5 parts by weight of amino acid derivative, 6 parts by weight of alcohol, 6 parts by weight of fatty alcohol-polyoxyethylene ether and 4 parts by weight of builder.
In a more preferred embodiment, the preparation raw material further comprises 0.05-0.2 parts by weight of preservative.
In a more preferred embodiment, the preparation raw material further comprises 0.13 parts by weight of a preservative.
In a more preferred embodiment, the preparation raw materials further comprise a proper amount of essence and sodium hydroxide.
<Amino acid derivatives>
The amino acid derivative disclosed by the invention is a compound containing amino and carboxyl in molecules.
In one embodiment, the amino acid derivative is selected from the group consisting of lauroyl alanine (CAS: 52558-74-4), 3- (hydroxynitrosoamino) alanine (CAS: 16931-22-9), Fmoc-D-4-thiazolylalanine (CAS: 205528-33-2), and combinations thereof.
In a preferred embodiment, the amino acid derivative is lauroyl alanine.
<Alcohols>
The alcohol is selected from one or a combination of more of 1, 2-propylene glycol, 1, 3-propylene glycol, mannitol and sorbitol.
In a preferred embodiment, the alcohol comprises 1, 2-propanediol.
In a more preferred embodiment, the alcohol further comprises mannitol or sorbitol.
In a more preferred embodiment, the weight ratio of 1, 2-propanediol to mannitol or sorbitol is (6-9): 1; more preferably, the weight ratio of 1, 2-propanediol to mannitol or sorbitol is 7.5: 1.
in the invention, the addition of alcohols can improve the moisturizing effect and is beneficial to system stability, while in different alcohol attempts, the inventor unexpectedly finds that the appearance of the 1, 2-propylene glycol system is better than that of the 1, 3-propylene glycol system, and the appearance of the 1, 2-propylene glycol system is maintained stable by compounding a small amount of mannitol, and the inventor unexpectedly finds that when the weight ratio of the 1, 2-propylene glycol to the mannitol/sorbitol is (6-9): 1, the low-temperature stability of the composition is obviously improved, and the inventor speculates that the hydroxyl structures of adjacent molecules in the mannitol/sorbitol can be effectively assembled with the lauroyl alanine through intermolecular hydrogen bonds, the addition of the 1, 2-propylene glycol promotes the head ends of two molecules of the lauroyl alanine to be connected with the mannitol/sorbitol through hydrogen bonds, the tail ends of two molecules of the lauroyl alanine are mutually associated to form a single closed ring structure, the rings are sequentially stacked to form a hollow tubular structure, and the 1, 3-propylene glycol can form an intramolecular six-membered ring structure by itself to prevent the formation of a self-assembled structure.
<Fatty alcohol polyoxyethylene ether>
The fatty alcohol-polyoxyethylene ether (CAS: 68131-39-5) is also called polyoxyethylene fatty alcohol ether and is used as a nonionic surfactant to play roles in emulsification, foaming and decontamination.
<Builder>
The builder of the present invention comprises guanidinoacetic acid.
In a preferred embodiment, the builder further comprises citric acid.
In a more preferred embodiment, the weight ratio of guanidinoacetic acid to citric acid is 1: (4.8-5.8); more preferably, the weight ratio of guanidinoacetic acid to citric acid is 1: 5.3.
in a more preferred embodiment, the weight ratio of builder to alcohol is 1: (1-2); more preferably, the weight ratio of builder to alcohol is 1: 1.5.
the inventor finds that the detergency can be effectively improved by using the builder, and the detergency of the system can be remarkably improved when the builder comprises guanidinoacetic acid and citric acid, and the inventor also finds that when the weight ratio of the guanidinoacetic acid to the citric acid is 1: (4.8-5.8), the heat and cold resistance stability of the system is excellent, and the cleaning performance and stability are reduced when citric acid is singly used, the inventor speculates that the acidity of the citric acid is stronger than that of the guanidinoacetic acid, the carboxyl of the citric acid interacts with the amino of the guanidinoacetic acid, the carboxyl of the guanidinoacetic acid interacts with the amino of the lauroyl alanine, and the hydrogen bonding of mannitol/sorbitol and the lauroyl alanine improves the solubility of the builder, and the specific geometric configuration and the charge distribution in the geometric configuration lead to head-to-tail order connection, so that a larger hollow tubular structure is formed by stacking, and the decontamination effect and the stability are improved.
The inventors have found that when the weight ratio of builder to alcohol in the present invention is 1: (1-2), the stability is improved, particularly the heat-resistant stability is obviously improved, the inventor speculates that on one hand, a stronger non-covalent bond effect is possibly formed between a hydrophilic group of a hollow tubular structure and a hydrophilic group of fatty alcohol polyoxyethylene ether, the enrichment of the hollow tubular structure increases the interfacial tension, the interfacial film strength is increased, and further the system stability is improved, on the other hand, the molecular motion energy is larger at high temperature, and through the interaction of alcohol, a builder and amino acid, particles such as alcohol, builder and the like are bound within a certain time, so that the motion process is hindered, and the high-temperature stability is improved.
<Preservative>
The preservative is selected from one or a combination of more of sodium benzoate, potassium sorbate, N-hydroxymethyl sodium glycinate, 5-chloro-2-methyl-4-isothiazoline-3-ketone and 2-methyl-4-isothiazoline-3-ketone.
In a preferred embodiment, the preservative is sodium benzoate.
<Essence>
The essence is commonly used in the industry, is lavender essence, and is purchased from Jinan Ji Yi Li chemical Co. In the formula, corresponding essence can be freely selected according to the requirement.
<Sodium hydroxide>
The molar concentration of the sodium hydroxide is 1mol/L, and the sodium hydroxide is used for adjusting the pH of a system.
The second aspect of the invention provides a preparation method of the environment-friendly sterilization composition, which at least comprises the following steps: adding the components into a mixer, and stirring and mixing uniformly to obtain the product.
In a preferred embodiment, the preparation method of the environment-friendly sterilization composition at least comprises the following steps: adding the components into a mixer at 20-30 ℃, and stirring for 2-5 min to mix uniformly to obtain the product.
The environment-friendly bactericidal composition can be applied to various cleaning agent products, is suitable for cleaning various clothes and fabrics such as down jackets, sweaters, curtains and the like, and can be applied to products such as hand sanitizer, dishwashing liquid, toilet cleaner and the like.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials used are all commercially available, unless otherwise specified.
Example 1
Embodiment 1 of the invention provides an environment-friendly bactericidal composition, which comprises, by weight, 1.5 parts of amino acid derivatives, 5 parts of alcohols, 4 parts of fatty alcohol-polyoxyethylene ether and 5 parts of builders.
The preparation raw materials also comprise 0.1 part of preservative.
The preparation raw materials also comprise a proper amount of essence and sodium hydroxide.
The amino acid derivative is lauroyl alanine.
The alcohols include 1, 2-propanediol.
The alcohols also include mannitol.
The weight ratio of the 1, 2-propylene glycol to the mannitol is 6: 1.
the builder of the present invention comprises guanidinoacetic acid.
The builder also includes citric acid.
The weight ratio of the guanidinoacetic acid to the citric acid is 1: 4.8.
the preservative is sodium benzoate.
The essence is lavender essence and is purchased from Jinan Jiyi Yili chemical Co.
The molar concentration of the sodium hydroxide is 1 mol/L.
The preparation method of the environment-friendly sterilization composition comprises the following steps: adding the components into a mixer at 25 deg.C, stirring for 4min, and mixing.
Example 2
Embodiment 2 of the invention provides an environment-friendly bactericidal composition, which comprises, by weight, 4 parts of amino acid derivatives, 6.7 parts of alcohols, 8 parts of fatty alcohol-polyoxyethylene ether and 3.3 parts of builders.
The preparation raw materials also comprise 0.18 part of preservative.
The preparation raw materials also comprise a proper amount of essence and sodium hydroxide.
The amino acid derivative is lauroyl alanine.
The alcohols include 1, 2-propanediol.
The alcohols also include mannitol.
The weight ratio of the 1, 2-propylene glycol to the mannitol is 9: 1.
the builder of the present invention comprises guanidinoacetic acid.
The builder also includes citric acid.
The weight ratio of the guanidinoacetic acid to the citric acid is 1: 5.8.
the preservative is sodium benzoate.
The essence is lavender essence and is purchased from Jinan Jiyi Yili chemical Co.
The molar concentration of the sodium hydroxide is 1 mol/L.
The preparation steps of the environment-friendly sterilization composition are the same as those of the embodiment 1.
Example 3
Embodiment 3 of the invention provides an environment-friendly bactericidal composition, which comprises, by weight, 2.5 parts of amino acid derivatives, 6 parts of alcohols, 6 parts of fatty alcohol-polyoxyethylene ether and 4 parts of builders.
The preparation raw materials also comprise 0.13 part of preservative.
The preparation raw materials also comprise a proper amount of essence and sodium hydroxide.
The amino acid derivative is lauroyl alanine.
The alcohols include 1, 2-propanediol.
The alcohols also include mannitol.
The weight ratio of the 1, 2-propylene glycol to the mannitol is 7.5: 1.
the builder of the present invention comprises guanidinoacetic acid.
The builder also includes citric acid.
The weight ratio of the guanidinoacetic acid to the citric acid is 1: 5.3.
the preservative is sodium benzoate.
The essence is lavender essence and is purchased from Jinan Jiyi Yili chemical Co.
The molar concentration of the sodium hydroxide is 1 mol/L.
The preparation steps of the environment-friendly sterilization composition are the same as those of the embodiment 1.
Comparative example 1
Comparative example 1 of the present invention provides an environmentally friendly germicidal composition, which is similar to example 3 except that the weight ratio of 1, 2-propanediol to mannitol is replaced with 3: 1.
comparative example 2
Comparative example 2 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3, except that 1, 2-propanediol is replaced with 1, 3-propanediol.
Comparative example 3
Comparative example 3 of the present invention provides an eco-friendly composition, which is similar to example 3, except that 1, 2-propanediol is not included.
Comparative example 4
Comparative example 4 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3, except that mannitol is not included.
Comparative example 5
Comparative example 5 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3 except that citric acid is not present.
Comparative example 6
Comparative example 6 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3, except that guanidinoacetic acid is not present.
Comparative example 7
Comparative example 7 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3, except that no builder is present.
Comparative example 8
Comparative example 8 of the present invention provides an eco-friendly germicidal composition, which is similar to example 3 except that the builder is used in an amount of 11 parts.
Comparative example 9
Comparative example 9 of the present invention provides an eco-friendly composition, which is similar to example 3, except that no alcohol is present.
Performance testing
1. Appearance delamination test
A direct observation method is adopted to observe whether the compositions prepared in the examples 1-3, the comparative examples 1-4 and the comparative examples 8-9 are layered or not, namely, whether the sample is layered or has obvious suspended matters or precipitates or mechanical impurities. Each example was provided with 100 parallel samples, and the probability of delamination of the appearance of the samples, i.e. the number of samples delaminated, was recorded as a percentage of the total number tested.
2. Stability test
Heat resistance stability: the compositions prepared in examples 1-3 and comparative examples 5-9 were kept at 40 ℃ for 24 hours, and whether there was a significant change after returning to room temperature was recorded compared to before the experiment, 100 parallel samples were set for each example, and the probability of the significant change in the samples, i.e., the percentage of the number of samples that have undergone a significant change to the total number tested, was recorded.
Cold resistance stability: the compositions prepared in examples 1-3 and comparative examples 1-9 were kept at-5 ℃ for 24 hours, and it was recorded whether there was a significant change after returning to room temperature compared to before the experiment, 100 parallel samples were set for each example, and the probability of the significant change in the samples, i.e., the percentage of the number of samples that had undergone a significant change to the total number tested, was recorded.
3. Detergency test
Manufacturing the polluted cloth: taking cotton cloth required by national standard MLBT42882008 as a stain cloth substrate, coating stains on the surface of the stain cloth substrate, wherein the types of the stains are as follows: the chili oil, after drying, was used for testing and cut into pieces of 120 × 120mm size.
Dry cleaning test: manufacturing a small bucket with the volume of 2 liters, fixing the small bucket on equipment rotating like a roller, simulating a roller washing mode to carry out a decontamination performance test, taking 1 piece of dirty cloth with the size of 120mm, adding 1kg of the composition prepared in examples 1-3 and comparative examples 5-7, washing at normal temperature for 30min, taking out the dirty cloth after the completion, naturally airing, testing the whiteness of the dirty cloth, recording the change rate of the whiteness before and after washing, respectively setting 10 parallel samples in each example, and finally taking an average value.
TABLE 1
TABLE 2
| Layer (%) | Cold resistance stability (%) | |
| Comparative example 1 | 10 | 10 |
| Comparative example 2 | 30 | 10 |
| Comparative example 3 | 45 | 50 |
| Comparative example 4 | 30 | 30 |
TABLE 3
TABLE 4
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (2)
1. An environment-friendly sterilization composition is characterized in that the preparation raw materials at least comprise, by weight, 0.1-5 parts of amino acid derivatives, 2-10 parts of alcohols, 2-10 parts of fatty alcohol-polyoxyethylene ether and 0.1-10 parts of builders;
the amino acid derivative is lauroyl alanine;
the alcohols include 1, 2-propanediol;
the alcohols also include mannitol or sorbitol;
the weight ratio of the 1, 2-propylene glycol to the mannitol or the sorbitol is (6-9): 1;
the builder comprises guanidinoacetic acid;
the builder further comprises citric acid;
the weight ratio of the guanidinoacetic acid to the citric acid is 1: (4.8-5.8);
the preparation raw materials also comprise 0.05-0.2 part of preservative by weight;
the weight ratio of the builder to the alcohol is 1: (1-2).
2. The preparation method of the environment-friendly sterilization composition according to claim 1, characterized by at least comprising the following steps: adding the components into a mixer, and stirring and mixing uniformly to obtain the product.
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