CN111094339A - 抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 - Google Patents
抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 Download PDFInfo
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Abstract
提供一种抗PD‑1抗体和抗LAG‑3抗体联合在制备治疗肿瘤的药物中的用途。具体而言，涉及抗PD‑1抗体或其抗原结合片段和抗LAG‑3抗体或其抗原结合片段联合在制备治疗肿瘤和/或增强T细胞活性的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017109659268 | 2017-10-17 | ||
| CN201710965926 | 2017-10-17 | ||
| PCT/CN2018/110324 WO2019076277A1 (zh) | 2017-10-17 | 2018-10-16 | 抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111094339A true CN111094339A (zh) | 2020-05-01 |
| CN111094339B CN111094339B (zh) | 2023-01-24 |
Family
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|---|---|---|---|
| CN201880059078.7A Active CN111094339B (zh) | 2017-10-17 | 2018-10-16 | 抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN111094339B (zh) |
| TW (1) | TW201916890A (zh) |
| WO (1) | WO2019076277A1 (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616788A (zh) * | 2020-05-08 | 2021-11-09 | 勤浩医药（苏州）有限公司 | 抗lag-3抗体与shp-2抑制剂联合治疗肿瘤的用途 |
| CN115845052A (zh) * | 2022-12-28 | 2023-03-28 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗结肠癌中的应用 |
| CN115845051A (zh) * | 2022-12-28 | 2023-03-28 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗肝癌中的应用 |
| CN115869399A (zh) * | 2022-12-28 | 2023-03-31 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗非小细胞肺癌中的应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114522229B (zh) * | 2022-02-25 | 2023-09-29 | 南京大学 | 一种减毒沙门氏菌和pd-1抗体抑制剂联合药物及其在制备治疗肿瘤药物中的应用 |
| WO2025056011A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105793287A (zh) * | 2013-09-20 | 2016-07-20 | 百时美施贵宝公司 | 抗lag-3抗体与抗pd-1抗体联合治疗肿瘤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| ES2566602T3 (es) * | 2010-04-09 | 2016-04-14 | Aveo Pharmaceuticals, Inc. | Anticuerpos anti-ErbB3 |
| JP2016517441A (ja) * | 2013-03-15 | 2016-06-16 | ジェネンテック， インコーポレイテッド | 抗ＣＲＴｈ２抗体及び使用方法 |
| WO2015048312A1 (en) * | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| SG10201804945WA (en) * | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| CN106999591B (zh) * | 2015-09-28 | 2021-02-23 | 苏州盛迪亚生物医药有限公司 | 一种抗pd-1抗体制剂及其在医药上的应用 |
-
2018
- 2018-10-16 WO PCT/CN2018/110324 patent/WO2019076277A1/zh not_active Ceased
- 2018-10-16 CN CN201880059078.7A patent/CN111094339B/zh active Active
- 2018-10-16 TW TW107136365A patent/TW201916890A/zh unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105793287A (zh) * | 2013-09-20 | 2016-07-20 | 百时美施贵宝公司 | 抗lag-3抗体与抗pd-1抗体联合治疗肿瘤 |
Non-Patent Citations (1)
| Title |
|---|
| BUROVA, ELENA等: "Combined treatment with anti-LAG-3 and anti-PD-1 fully human monoclonal antibodies inhibits tumor growth in immunocompetent double humanized LAG-3/PD-1 mice", 《CANCER RESEARCH》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616788A (zh) * | 2020-05-08 | 2021-11-09 | 勤浩医药（苏州）有限公司 | 抗lag-3抗体与shp-2抑制剂联合治疗肿瘤的用途 |
| CN115845052A (zh) * | 2022-12-28 | 2023-03-28 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗结肠癌中的应用 |
| CN115845051A (zh) * | 2022-12-28 | 2023-03-28 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗肝癌中的应用 |
| CN115869399A (zh) * | 2022-12-28 | 2023-03-31 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗非小细胞肺癌中的应用 |
| CN115845052B (zh) * | 2022-12-28 | 2023-12-29 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗结肠癌中的应用 |
| CN115869399B (zh) * | 2022-12-28 | 2024-01-12 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗非小细胞肺癌中的应用 |
| CN115845051B (zh) * | 2022-12-28 | 2024-02-02 | 广州誉衡生物科技有限公司 | 一种药物组合物和药物制剂及其在治疗肝癌中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201916890A (zh) | 2019-05-01 |
| CN111094339B (zh) | 2023-01-24 |
| WO2019076277A1 (zh) | 2019-04-25 |
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