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CN111094279A - 一种苯并呋喃衍生物的制备方法 - Google Patents

一种苯并呋喃衍生物的制备方法 Download PDF

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Publication number
CN111094279A
CN111094279A CN201880059239.2A CN201880059239A CN111094279A CN 111094279 A CN111094279 A CN 111094279A CN 201880059239 A CN201880059239 A CN 201880059239A CN 111094279 A CN111094279 A CN 111094279A
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China
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formula
compound
groups
alkyl
preparation
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CN201880059239.2A
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English (en)
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CN111094279B (zh
Inventor
陆伟栋
徐超
张浩宇
邵启云
冯君
贺峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Publication of CN111094279A publication Critical patent/CN111094279A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

一种苯并呋喃衍生物的制备方法。具体而言，提供一种苯并呋喃衍生物的制备方法，根据提供的方法，可以有效的缩短现有技术中合成苯并呋喃类物质所需的反应步骤。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201880059239.2A 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法 Active CN111094279B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201711104888 2017-11-10
CN2017111048883 2017-11-10
PCT/CN2018/114798 WO2019091450A1 (zh) 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法

Publications (2)

Publication Number Publication Date
CN111094279A true CN111094279A (zh) 2020-05-01
CN111094279B CN111094279B (zh) 2023-06-16

Family

ID=66438760

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880059239.2A Active CN111094279B (zh) 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法

Country Status (8)

Country Link
US (1) US11390614B2 (zh)
EP (1) EP3708567A4 (zh)
JP (2) JP7295105B6 (zh)
CN (1) CN111094279B (zh)
AU (2) AU2018363467B2 (zh)
MX (1) MX395591B (zh)
TW (1) TWI717656B (zh)
WO (1) WO2019091450A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456156A (zh) * 2020-11-09 2022-05-10 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的纯化方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020228591A1 (zh) * 2019-05-10 2020-11-19 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的制备方法
CA3234851A1 (en) 2021-10-15 2023-04-20 Ya CHEN Method for preparing benzofuran derivative
CN113861002B (zh) * 2021-11-02 2024-04-26 琼台师范学院 一种无金属催化体系催化氧化芳香醇类制备芳香酮类化合物的方法
KR20250023481A (ko) 2022-06-13 2025-02-18 트리라인 바이오사이언시스, 인크. 1,8-나프티리딘-2-온 이종이작용성 bcl6 분해제
CA3258325A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. BIFUNCTIONAL QUINOLONE DEGRADING AGENTS BCL6
WO2024260368A1 (zh) * 2023-06-19 2024-12-26 江苏恒瑞医药股份有限公司 一种苯并呋喃衍生物及其中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236625A (en) * 1963-07-18 1966-02-22 Tenneco Chem Method of inhibiting plant growth
CN1426388A (zh) * 2000-04-28 2003-06-25 日本农药株式会社 生产2－卤代苯甲酸的方法
CN101434582A (zh) * 2008-11-28 2009-05-20 华东理工大学 苯甲酸(苯并三唑基)苯酯类化合物
WO2011140325A1 (en) * 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用

Family Cites Families (8)

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JP3233678B2 (ja) * 1991-06-27 2001-11-26 日本化学工業株式会社 ｏ−アルコキシ安息香酸の製造方法
AU4454597A (en) 1996-08-19 1998-03-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzofuran-4-carboxamides
GB0003257D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
FR2923826A1 (fr) * 2007-11-21 2009-05-22 Ppg Sipsy Soc Par Actions Simp Procede de synthese de l'acide 4-benzofurane carboxylique
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
US9073924B2 (en) 2011-09-13 2015-07-07 Glaxosmithkline Llc Azaindazoles
RS60022B1 (sr) 2014-03-17 2020-04-30 Daiichi Sankyo Co Ltd 1,3-benzodioksol derivati kao ezh1 i/ili ezh2 inhibitori

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236625A (en) * 1963-07-18 1966-02-22 Tenneco Chem Method of inhibiting plant growth
CN1426388A (zh) * 2000-04-28 2003-06-25 日本农药株式会社 生产2－卤代苯甲酸的方法
CN101434582A (zh) * 2008-11-28 2009-05-20 华东理工大学 苯甲酸(苯并三唑基)苯酯类化合物
WO2011140325A1 (en) * 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HIDETSUGU TABATA 等: ""A complete gear system in n-benzoyl-carbazole derivatives"", 《ORGANIC LETTERS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456156A (zh) * 2020-11-09 2022-05-10 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的纯化方法

Also Published As

Publication number Publication date
MX2020004869A (es) 2020-08-06
TW201918469A (zh) 2019-05-16
JP7526856B2 (ja) 2024-08-01
TWI717656B (zh) 2021-02-01
JP2023123543A (ja) 2023-09-05
WO2019091450A1 (zh) 2019-05-16
JP7295105B6 (ja) 2023-07-24
JP2021502376A (ja) 2021-01-28
MX395591B (es) 2025-03-25
AU2018363467A1 (en) 2020-06-04
EP3708567A4 (en) 2021-07-07
AU2023278061B2 (en) 2025-11-13
AU2018363467B2 (en) 2023-09-07
JP7295105B2 (ja) 2023-06-20
US20210188822A1 (en) 2021-06-24
US11390614B2 (en) 2022-07-19
EP3708567A1 (en) 2020-09-16
CN111094279B (zh) 2023-06-16
RU2020118301A (ru) 2021-12-10
RU2020118301A3 (zh) 2022-01-27
AU2023278061A1 (en) 2024-01-04

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