CN111011601A - Natural composite antioxidant for animal feed and preparation method thereof - Google Patents
Natural composite antioxidant for animal feed and preparation method thereof Download PDFInfo
- Publication number
- CN111011601A CN111011601A CN201911375761.4A CN201911375761A CN111011601A CN 111011601 A CN111011601 A CN 111011601A CN 201911375761 A CN201911375761 A CN 201911375761A CN 111011601 A CN111011601 A CN 111011601A
- Authority
- CN
- China
- Prior art keywords
- antioxidant
- feed
- animal feed
- citric acid
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 65
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 61
- 241001465754 Metazoa Species 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000002131 composite material Substances 0.000 title abstract description 14
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 64
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 46
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 22
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 17
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 17
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 17
- 239000001168 astaxanthin Substances 0.000 claims abstract description 17
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 17
- 235000019136 lipoic acid Nutrition 0.000 claims abstract description 14
- 229940092258 rosemary extract Drugs 0.000 claims abstract description 14
- 235000020748 rosemary extract Nutrition 0.000 claims abstract description 14
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims abstract description 14
- 229960002663 thioctic acid Drugs 0.000 claims abstract description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims abstract 3
- 239000000047 product Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 21
- 229960004106 citric acid Drugs 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- 229930014626 natural product Natural products 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229960002303 citric acid monohydrate Drugs 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000011265 semifinished product Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 7
- 238000003860 storage Methods 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 description 13
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 235000019197 fats Nutrition 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 241000287828 Gallus gallus Species 0.000 description 5
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 5
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000000050 nutritive effect Effects 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 235000014590 basal diet Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- AZJQQNWSSLCLJN-UHFFFAOYSA-N 2-ethoxyquinoline Chemical compound C1=CC=CC2=NC(OCC)=CC=C21 AZJQQNWSSLCLJN-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 108010011619 6-Phytase Proteins 0.000 description 1
- XUSYGBPHQBWGAD-PJSUUKDQSA-N Carnosol Chemical compound CC([C@@H]1C2)(C)CCC[C@@]11C(=O)O[C@@H]2C2=C1C(O)=C(O)C(C(C)C)=C2 XUSYGBPHQBWGAD-PJSUUKDQSA-N 0.000 description 1
- MMFRMKXYTWBMOM-UHFFFAOYSA-N Carnosol Natural products CCc1cc2C3CC4C(C)(C)CCCC4(C(=O)O3)c2c(O)c1O MMFRMKXYTWBMOM-UHFFFAOYSA-N 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241000143510 Haliotis discus hannai Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 235000004654 carnosol Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007674 genetic toxicity Effects 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a natural composite antioxidant for animal feed and a preparation method thereof, wherein the natural composite antioxidant comprises the following raw materials in percentage by weight: 1-5% of astaxanthin, 1-10% of rosemary extract, 5-20% of lipoic acid, 1-7% of vitamin C, 2-6% of citric acid and the balance of a carrier. The antioxidant solves the problem that the existing feed antioxidant is poor in antioxidant effect generally, can prevent or delay oxidative rancidity of fat in the feed by adding the antioxidant into high-fat feed, improves the stability of the feed and prolongs the storage period.
Description
Technical Field
The invention relates to the technical field of animal feed additives, in particular to a natural compound antioxidant for animal feed and a preparation method thereof.
Background
In the feed production, the raw materials with higher fat content are added to meet the energy and nutrition requirements of animals in different growth stages, but substances such as fat-soluble vitamin feed additives, pigments, flavoring agents and the like contained in the feed with high fat content are easily oxidized and rancid in the whole process of mixing, processing, storing, feeding and digesting, can be in contact with oxygen in the air to generate oxidation reaction, aldehyde and ketone harmful substances are generated, the feed quality is reduced, the harm such as reduction of the feed intake of animals, diarrhea, liver swelling and the like is caused, and even the lives of livestock and poultry are threatened when rancid is serious. The prior antioxidants mainly used in the feed industry are synthetic antioxidants, including Ethoxyquinoline (EQ), Butylhydroxyanisole (BHA), dibutylhydroxytoluene (BHT) and the like, but reports show that the antioxidants have carcinogenic and genetic toxicity to animals, can cause residue and enrichment in meat products, and cause food safety hazards to endanger human health, and the G/SPS/EU/190 bulletin issued by the European Union in 2017 in 2 months; stopping adding EQ into the feed; also, BHT and BHA added to animal feed have been reported to have higher carcinogenic risk than EQ. The disadvantages of these synthetic antioxidants will therefore lead to an increased market demand for natural sources, and the development of new natural antioxidants is of great importance.
The antioxidant effect of natural extracts has certain limitations, such as lower antioxidant property, while the composite natural antioxidant is more superior. 2 or more than 2 natural antioxidants are compounded, and because the plurality of components can make up the deficiency of a single extract, the antioxidant effect is better than that of the single extract. The working principle of the composite antioxidant is to repair and regenerate, couple and oxidize, absorb oxygen, change enzyme activity and complex metal ions, and all the components are matched with each other to achieve better antioxidant effect.
The main components of rosemary extract are rosmarinol, carnosol and carnosic acid. The main components in the rosemary extract have strong antioxidant activity. Has obvious effect on preventing the oxidation of the grease feed, and the effect is better than that of a chemical synthetic product BHT + BHA, and the product is a common natural antioxidant.
The natural astaxanthin has a special molecular structure, is a strong quencher of singlet oxygen, has strong capacity of scavenging oxygen free radicals, and is an extremely effective antioxidant. Adding astaxanthin into feed for aquaculture to prevent deterioration of processed aquatic product such as rainbow trout due to lipid oxidation; it can also improve laying rate of hen and promote health of hen; promoting the growth of the chicks and the utilization rate of the feed, reducing the death rate of the chicks, improving the hatchability, resisting the infection of salmonella and prolonging the shelf life of the eggs. The astaxanthin is used as feed additive for feeding boar, and can increase boar semen volume and improve piglet volume and survival rate. Astaxanthin is also an active stress-resistant factor, which enhances the stress-resistance of farm animals and domestic pets, and minimizes weight loss and reduced immunity due to extreme temperatures and other sudden environmental changes.
Lipoic acid is a unique non-nutritive antioxidant with both fat solubility and water solubility, is easy to absorb, can be distributed to all parts of an organism to play a role, and even can permeate blood brain barrier to protect the organism from being damaged by oxidation. When 200 mg/kg-800 mg/kg of lipoic acid is added into the daily ration, the addition amount of the lipoic acid has positive correlation with the oxidation resistance and growth of the Haliotis discus hannai.
Therefore, the above conventional feed antioxidants have disadvantages and drawbacks in terms of ingredients and usage, and further improvement is needed. In order to solve the problems of the feed antioxidant, the relevant manufacturers have tried to solve the problems without diligent thought, but there has been no suitable design developed and completed for a long time, and there is no suitable product to solve the problems, which is obviously a problem to be solved urgently by the relevant manufacturers.
In view of the above-mentioned shortcomings of the conventional feed antioxidants, the present inventors have made extensive research and innovation based on practical experience and professional knowledge of many years of design and manufacture of such products in combination with the application of theory, in order to create a novel natural complex antioxidant for animal feeds and a preparation method thereof, which can improve the shortcomings of the conventional antioxidant components and make the antioxidant more practical. After continuous research and design and repeated trial and improvement, the invention with practical value is finally created.
Disclosure of Invention
The invention aims to overcome the defect of poor antioxidant effect of the existing feed antioxidant, and provides a novel natural compound antioxidant for animal feed and a preparation method thereof, aiming at solving the technical problems of preventing or delaying the oxidative rancidity of fat in the feed, improving the feed stability and prolonging the storage period, thereby being more practical and having industrial utilization value.
The purpose of the invention and the technical problem to be solved are realized by adopting the following technical scheme.
The invention provides a natural composite antioxidant for animal feed, which comprises the following raw materials in percentage by weight: 1-5% of astaxanthin, 1-10% of rosemary extract, 5-20% of lipoic acid, 1-7% of vitamin C, 2-6% of citric acid and the balance of a carrier.
The natural compound antioxidant for animal feed comprises the following raw materials in percentage by weight: 3% of astaxanthin, 6% of rosemary extract, 13% of lipoic acid, 4% of vitamin C, 4% of citric acid and the balance of a carrier.
The natural composite antioxidant for animal feed is described above, wherein the citric acid is citric acid monohydrate or citric acid anhydrous.
The natural composite antioxidant for animal feed, wherein the carrier is corncob.
The object of the present invention and the technical problems solved thereby can be further achieved by the following technical measures.
According to the present invention, there is provided a method for preparing the natural complex antioxidant for animal feed as described above, wherein the method comprises the steps of:
(1) crushing the first raw material at normal temperature to enable the fineness of the raw material to reach more than 60 meshes to obtain a first material for later use;
(2) preparing the material I in the step (1) and an anti-caking agent into a powdery semi-finished product according to a proportion to obtain a material II for later use;
(3) premixing and crushing the second raw material and the carrier, and enabling the weight of the second raw material to be 10% -50% of the total weight to obtain a third material for later use;
(4) and fully and uniformly mixing the second material and the third material, sieving, and packaging into a product to obtain the natural compound antioxidant for the animal feed.
In the preparation method, in the step (1), the first raw material is a mixture of zinc sulfate and citric acid.
In the preparation method, in the step (2), the anti-caking agent is silicon dioxide.
The preparation method comprises the step (2) of mixing the first material and the anti-caking agent according to the mass ratio of 2.5: 1.
In the above preparation method, in the step (3), the second raw material is a mixture of astaxanthin, rosemary extract and vitamin C.
The above-mentioned preparation methods, wherein the above-mentioned preparation methods are all carried out in a nitrogen atmosphere.
By the technical scheme, the invention at least has the following advantages:
1. preventing or delaying the oxidative rancidity of fat in the feed, improving the stability of the feed and prolonging the storage period.
2. Prevent the oxidative deterioration of protein and vitamins in the feed, preserve the nutritive value of the feed and is beneficial to the healthy growth of animals.
3. The feed conversion rate is improved.
4. Eliminating redundant free radicals in animal body, regulating immunity and improving quality of animal product.
In conclusion, the special natural compound antioxidant for the animal feed and the preparation method thereof solve the problem that the existing feed antioxidant is poor in oxidation resistance effect generally, and the aims of preventing or delaying the oxidative rancidity of fat in the feed, improving the feed stability and prolonging the storage period by adding the natural compound antioxidant into the high-fat feed are achieved. The feed antioxidant has the advantages and practical values, does not have similar design publication or use in similar products, is innovative, has great improvement on component composition or preparation method, has great technical progress, produces good and practical effects, has multiple enhanced efficacies compared with the existing feed antioxidant, is more suitable for practical use, has industrial wide utilization value, and is a novel, improved and practical new design.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical solutions of the present invention more clearly understood and to implement them in accordance with the contents of the description, the following detailed description is given with reference to the preferred embodiments of the present invention and the accompanying drawings.
Specific products of the present invention and methods for preparing the same are detailed in the following examples and figures thereof.
Drawings
Figure 1 shows a comparison of the effect of antioxidants in the examples of the invention and comparative examples on piglet growth performance.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. It will be apparent to those skilled in the art that the invention can be modified and replaced with other components having the same effects without departing from the spirit and scope of the invention, and all such modifications and substitutions are deemed to be within the scope of the invention.
The natural composite antioxidant for the animal feed comprises, by weight, 1% -5% of astaxanthin, 1% -10% of rosemary extract, 5% -20% of lipoic acid, 1-7% of vitamin C, 2% -6% of citric acid and the balance of a carrier, wherein the carrier is corncob, the astaxanthin is naturally extracted astaxanthin and is a food or feed grade product, the rosemary extract is a food or feed grade product, the lipoic acid is α -lipoic acid and is a feed grade product, the citric acid is citric acid monohydrate or anhydrous citric acid and is a food or feed grade product, and the vitamin C is L-ascorbic acid and is a feed grade product.
The natural composite antioxidant for the animal feed is prepared according to the following steps, and specifically comprises the following steps:
(1) crushing the first raw material at normal temperature to enable the fineness of the raw material to reach more than 60 meshes to obtain a first material for later use;
(2) preparing the material I in the step (1) and an anti-caking agent into a powdery semi-finished product according to a proportion to obtain a material II for later use;
(3) premixing and crushing the second raw material and the carrier, and enabling the weight of the second raw material to be 10% -50% of the total weight to obtain a third material for later use;
(4) and fully and uniformly mixing the second material and the third material, sieving, and packaging into a product to obtain the natural compound antioxidant for the animal feed.
The following examples 1 to 3 were all prepared according to the above formulation and method.
Example 1
A natural composite antioxidant for animal feed is prepared from the following components in parts by weight: 3 parts of astaxanthin, 6 parts of rosemary extract, 13 parts of lipoic acid, 4 parts of vitamin C, 4 parts of citric acid and 70 parts of corncob.
Example 2
A natural composite antioxidant for animal feed is prepared from the following components in parts by weight: 5 parts of astaxanthin, 10 parts of rosemary extract, 5 parts of lipoic acid, 1 parts of vitamin C, 2 parts of citric acid and 77 parts of corncobs.
Example 3
A natural composite antioxidant for animal feed is prepared from the following components in parts by weight: 1 part of astaxanthin, 1 part of rosemary extract, 20 parts of lipoic acid, 7 parts of vitamin C, 6 parts of citric acid and 65 parts of corncobs.
Comparative example 1
The antioxidant comprises BHT and BHA, and the addition amount is 400g/t, namely 400g of antioxidant is added in each ton of feed.
Test example I, Effect of Complex antioxidant on broiler chickens
1. Test products: the antioxidant of example 1 and the antioxidant of comparative example 1 were added to the feed in an amount of 400 g/ton of feed, and the antioxidants were designated as test group B and control group a.
Subject: ross 308 broiler chickens are all selected from the same batch, the same farm and the same culture conditions, and the batch culture number is about 600 chickens
Grouping: randomly dividing into two groups of 300 pieces, and keeping the ratio of male to female in each group to be basically the same
Shed conditions for cultivation: the area, lighting, ventilation, heat preservation, illumination, roosting, bedding, tank material and the like of each shed are the same, and the disinfection, sterilization and epidemic prevention of the shed are the same.
2. The test method comprises the following steps: feeding and breeding
Experiment time: 7/month 1 to 8/month 11 in 2018
Daily ration in the growth period (1-35 days): 12.5MJ/kg daily ration (36-42 days) in fattening period: 13.0MJ/kg, from birth to 42 days in the test period, in addition, the medicines and the nutrient substances which are added into the compound feed are all consistent, and the feeding frequency and the feeding amount are also all consistent. Specific results are shown in table 1.
Table 1 influence of formula ration of feeding test group B/control group A on broiler chicken production performance
| Item | Control group A | Test group B |
| Number of animals | 300 | 300 |
| Live weight of 1 day (g) | 41.5 | 41.5 |
| 35 day old live weight (g) | 1765* | 1826* |
| Live weight of 42 days (g) | 2331A | 2493B |
| 1-35 days feed conversion rate | 1.685a | 1.649b |
| 1-42 days feed conversion rate | 1.789A | 1.753B |
Labeling: p represents 0.067; a, B: p is less than or equal to 0.01; p is not more than 0.05
From the results, compared with the control group, the feed added with the antioxidant provided by the invention has the advantages that the live weight of the white feather broilers at 35 th and 42 th days is obviously improved, and the feed conversion rate is obviously improved.
Test example II Effect of antioxidants on growth Performance of piglets
1. Test products: the antioxidant of example 1 and the antioxidant of comparative example 1 were added to the basal diet in an amount of 400g of antioxidant per ton of feed, respectively, and named test group B and control group a, respectively, wherein the composition of the basal diet is shown in table 2.
Subject: 257 weaned piglets aged 28 days are fed with a control group and a test daily ration after 34 days, and the test is carried out for 28 days (2008.11-2009.1).
Grouping: control group a: 130 heads, test group B: 127 heads, grouped according to parental generation, age and sex, each group is 9 columns.
2. The test method comprises the following steps:
piglet weight at 1,14,28 days
1-14 days, 15-28 days, and 1-28 days for each fence
The weight of the piglets is increased for 1-14 days, 15-28 days and 1-28 days, and the specific results are shown in Table 3.
TABLE 2 basic daily ration composition and content
| Composition of daily ration | ％ |
| Wheat/barley | 49.3 |
| Grain by-product | 11.9 |
| Fibrous product | 9.1 |
| Protein product | 16.8 |
| Dairy product | 1.9 |
| Acids (lactic acid, formic acid, propionic acid, sorbic acid) | 0.9 |
| Amino acids | 0.9 |
| Mineral (part is organic product) | 2.4 |
| Fat and sugar honey | 5.7 |
| Premix compound | 1.1 |
| Enzyme preparation (phytase, carbohydrase) | 0.02 |
| Analytical value of daily ration | |
| Crude protein (%) | 18 |
| Crude fat (%) | 6.4 |
| Crude fiber (%) | 3.9 |
| Coarse ash (%) | 5.5 |
| Metabolizable energy (Kcal/kg dry matter) | 14.0 |
TABLE 3 comparison of the performance data of the piglets in the test group A and the control group B
The result is shown in figure 1, the addition of the antioxidant can increase the daily gain of weaned pigs and reduce the feed-weight ratio, so that the compound antioxidant can improve the utilization rate of feed, promote the healthy growth of the piglets and show better production performance.
In conclusion, the antioxidant of the invention can prevent or delay the oxidative rancidity of fat in feed, improve the stability of the feed and prolong the storage period. Prevent the oxidative deterioration of protein and vitamins in the feed, preserve the nutritive value of the feed and is beneficial to the healthy growth of animals. The feed conversion rate is improved. Eliminating redundant free radicals in animal body, regulating immunity and improving quality of animal product.
Although the present invention has been described with reference to a preferred embodiment, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A natural compound antioxidant for animal feed comprises the following raw materials in percentage by weight: 1-5% of astaxanthin, 1-10% of rosemary extract, 5-20% of lipoic acid, 1-7% of vitamin C, 2-6% of citric acid and the balance of a carrier.
2. The natural complex antioxidant for animal feed according to claim 1, comprising the following raw materials in percentage by weight: 3% of astaxanthin, 6% of rosemary extract, 13% of lipoic acid, 4% of vitamin C, 4% of citric acid and the balance of a carrier.
3. The natural complex antioxidant for animal feed according to claim 1, wherein the citric acid is citric acid monohydrate or citric acid anhydrous.
4. The natural complex antioxidant for animal feed according to claim 1, wherein the carrier is corncob.
5. A method for preparing the natural complex antioxidant for animal feed of any one of claims 1 to 4, wherein the method comprises the steps of:
(1) crushing the first raw material at normal temperature to enable the fineness of the raw material to reach more than 60 meshes to obtain a first material for later use;
(2) preparing the material I in the step (1) and an anti-caking agent into a powdery semi-finished product according to a proportion to obtain a material II for later use;
(3) premixing and crushing the second raw material and the carrier, and enabling the weight of the second raw material to be 10% -50% of the total weight to obtain a third material for later use;
(4) and fully and uniformly mixing the second material and the third material, sieving, and packaging into a product to obtain the natural compound antioxidant for the animal feed.
6. The preparation method of claim 5, wherein the first raw material in the step (1) is a mixture of zinc sulfate and citric acid.
7. The production method according to claim 5, wherein the anti-caking agent in the step (2) is silicon dioxide.
8. The preparation method according to claim 5, wherein the first material and the anti-caking agent are mixed in the step (2) according to a mass ratio of 2.5: 1.
9. The method according to claim 5, wherein the second raw material in the step (3) is a mixture of astaxanthin, rosemary extract and vitamin C.
10. The production method according to claim 5, wherein the production methods are all performed in a nitrogen atmosphere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911375761.4A CN111011601A (en) | 2019-12-27 | 2019-12-27 | Natural composite antioxidant for animal feed and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911375761.4A CN111011601A (en) | 2019-12-27 | 2019-12-27 | Natural composite antioxidant for animal feed and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111011601A true CN111011601A (en) | 2020-04-17 |
Family
ID=70195993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911375761.4A Pending CN111011601A (en) | 2019-12-27 | 2019-12-27 | Natural composite antioxidant for animal feed and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111011601A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112155132A (en) * | 2020-09-26 | 2021-01-01 | 北京华阜康生物科技股份有限公司 | High-reproduction feed for laboratory mice and production process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020110604A1 (en) * | 2000-08-11 | 2002-08-15 | Ashni Naturaceuticals, Inc. | Composition exhibiting synergistic antioxidant activity |
| US20100247504A1 (en) * | 2007-09-07 | 2010-09-30 | Fujifilm Corporation | Powder composition |
| CN106036353A (en) * | 2016-05-26 | 2016-10-26 | 上海邦成生物工程有限公司 | Preparation method and application of feed liquid compound antioxidant |
-
2019
- 2019-12-27 CN CN201911375761.4A patent/CN111011601A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020110604A1 (en) * | 2000-08-11 | 2002-08-15 | Ashni Naturaceuticals, Inc. | Composition exhibiting synergistic antioxidant activity |
| US20100247504A1 (en) * | 2007-09-07 | 2010-09-30 | Fujifilm Corporation | Powder composition |
| CN106036353A (en) * | 2016-05-26 | 2016-10-26 | 上海邦成生物工程有限公司 | Preparation method and application of feed liquid compound antioxidant |
Non-Patent Citations (1)
| Title |
|---|
| 付兴周等: "虾青素复合添加剂对肉鸡生长性能及肉质的影响", 《畜牧与兽医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112155132A (en) * | 2020-09-26 | 2021-01-01 | 北京华阜康生物科技股份有限公司 | High-reproduction feed for laboratory mice and production process thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Payne et al. | Effect of inorganic versus organic selenium on hen production and egg selenium concentration | |
| US8460719B1 (en) | Method of using nutritional supplement | |
| RU2628295C2 (en) | Poultry, swine or fish treatment for reducing fodder costs or increasing weight gain | |
| EP3378328B1 (en) | Use of animal nutrition fortifying agent | |
| RU2425586C1 (en) | Fodder mixture for growing quail birdlings | |
| CN111011601A (en) | Natural composite antioxidant for animal feed and preparation method thereof | |
| CN101917869A (en) | Formulations for improving carcass properties of pigs | |
| US11337443B2 (en) | Use of copper-calcium sulphate as animal feed additive | |
| Nikolayev et al. | Premixes in the feeding of broiler chickens | |
| EP4378320A1 (en) | Use of furan formic acid compound in preparing animal feed additive | |
| EP3656223B1 (en) | Food additive for animal feeds comprising food acids and essential oils | |
| US20020146502A1 (en) | Sorbic acid as growth-stabilizing addition to feedstuffs for agricultural livestock rearing | |
| Ait Issad et al. | Effects of a toxin binder and an organic acidifier on the zootechnical performance of broiler chickens | |
| US5977185A (en) | Method for prevention and treatment of production disease of genetically improved livestock and poultry | |
| Pastorelli et al. | Opuntia Spp. as Alternative Fodder for Sustainable Livestock Production. Animals 2022, 12, 1597 | |
| CN115067426A (en) | Application of 5-aminolevulinic acid in premixed feed for promoting growth of livestock and poultry | |
| WO2017143667A1 (en) | Feed composition and applications thereof in preparing animal feed additive | |
| CN105724779A (en) | Compound feeding composition and application of compound feeding composition in preparation of animal feed additive | |
| CN105815571A (en) | Feeding composition and application thereof to animal feed additive preparation | |
| MD1044Z (en) | Process for feeding pigs | |
| RU2851475C1 (en) | Method for improving productive qualities and survivability of young asian partridges (chukars) | |
| RU2095995C1 (en) | Method for feeding agricultural animals and poultry | |
| RU2762198C1 (en) | Method of feeding poultry with the introduction of an additive with phytobiotic activity into the feed | |
| CN109077178A (en) | A kind of premixed pig and raccoon dog feeding-stuff containing propolis and capsaicine | |
| Jassim et al. | Adding Variable Proportion of Moringa oleifera Leaves Flour and Pills Flour to Diet on the Productive Performance of Broilers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200417 |