CN1110173A - Jiuxin Yidiling liquid medicine for curing heart disease - Google Patents
Jiuxin Yidiling liquid medicine for curing heart disease Download PDFInfo
- Publication number
- CN1110173A CN1110173A CN 95100615 CN95100615A CN1110173A CN 1110173 A CN1110173 A CN 1110173A CN 95100615 CN95100615 CN 95100615 CN 95100615 A CN95100615 A CN 95100615A CN 1110173 A CN1110173 A CN 1110173A
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- medicine
- jiuxin
- yidiling
- heart disease
- liquid medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 239000007788 liquid Substances 0.000 title claims description 10
- 208000019622 heart disease Diseases 0.000 title claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 8
- 239000004615 ingredient Substances 0.000 claims abstract 2
- 235000015511 Liquidambar orientalis Nutrition 0.000 claims description 6
- 241000736148 Styrax Species 0.000 claims description 6
- 239000004870 Styrax Substances 0.000 claims description 6
- 235000000126 Styrax benzoin Nutrition 0.000 claims description 6
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 5
- 229940126672 traditional medicines Drugs 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 208000029078 coronary artery disease Diseases 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000402754 Erythranthe moschata Species 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 241001060310 Styracaceae Species 0.000 abstract 1
- 235000001361 Styrax officinalis Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 235000019382 gum benzoic Nutrition 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 239000006187 pill Substances 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000009982 suxiao jiuxinwan Substances 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 208000035824 paresthesia Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a Chinese proprietary- "Jiuxin Yidiling". Said medicine is an oral drop used for curing coronary heart disease and angina pectoris. The Chinese medicine ingredients of said drop are chuanxiong rhizome, borneol, storax, red sage root and musk, and mainly used for promoting blood circulation by removing blood stasis, inducing resuscitation by means of aromatics, making local micrangium dilate and promoting the absorption of medicine by human body so as to attain the goal of remitting angina pectoris symptom.
Description
The invention belongs to the Chinese Traditional Medicines in the clinical medicine technical field, specifically is a kind of oral cavity drop for the treatment of angina pectoris.
Treatment angina pectoris Chinese medicine adopts " SUXIAO JIUXIN WAN " more at present.This medicine is a pure Chinese medicinal preparation, and main component is Rhizoma Chuanxiong, Borneolum Syntheticum, reaches the purpose of allevating angina pectoris by the pharmacological action of blood circulation promoting and blood stasis dispelling, causing resuscitation with aromatic drugs.But this medicine is a Chinese medicine dripping pills, and containing is minimum 5 at every turn, generally needs the 10-15 grain.Because of pill need absorb a large amount of salivas in including of oral cavity, because the amount of salivating is limited at once in the oral cavity, factors such as asthma when adding the patient, perspiration owing to morbidity, saliva is reduced in the oral cavity, so melting time is longer, curative effect performance slow (general 10-15 minute).Sometimes have in the buccal medicine, the drink low amounts of water in the oral cavity to help medicine to dissolve.The Huashan Hospital of Shanghai First Medical College once adopted " Subing drop pills " (being made by Styrax, Borneolum Syntheticum figuration Polyethylene Glycol) treatment coronary heart disease angor, but medication pain relieving in 5 minutes, but it is a little less than this medicine function of promoting blood circulation to disperse blood clots,, poor to heart ischemia improvement effect though pain relieving is very fast.
The purpose of this invention is to provide a kind of Chinese patent medicine drop,, it can be reached absorb fully to overcome the deficiencies in the prior art, onset rapidly, the purpose improving myocardial ischemia, angina pectoris symptom is alleviated.
" Jiuxin Yidiling liquid medicine for curing heart disease " is to have carried out medicine a kind of liquid drops of making of prescription and form improvement again on the basis of above-mentioned two medicines.This medicine is by Rhizoma Chuanxiong 25g, Borneolum Syntheticum 5g, Styrax 2.5g, Radix Salviae Miltiorrhizae 25g, Moschus 0.1g, and the edible wine 100ml of 50-75% is processed into.Rhizoma Chuanxiong is a gas medicine in the blood, is traditional activating blood and removing stasis drug, has promoting flow of QI and blood, diffusing wind analgesic effect.Pharmacological research proves that Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae energy decreased heart rate, reduction left chamber diastole are not pressed and myocardial oxygen consumption, has coronary artery dilating, increases heart muscle perfusion, and the energy anticoagulant, anticoagulant, anti-thrombosis function are arranged.Remedied " Subing drop pills " blood circulation promoting and blood stasis dispelling defect of insufficient.On the basis of original Borneolum Syntheticum, add Styrax, Moschus and strengthened the curative effect of former " SUXIAO JIUXIN WAN " causing resuscitation with aromatic drugs, regulating QI to relieve pain.Used liquid excipient can make local Marjoram Extract, is beneficial to the fast Absorption of medicine.Said medicine is mixed and made into liquid drops, splashes into the oral cavity, and medicine need not containing can be absorbed rapidly, has remedied the long shortcoming of containing of drop pill soak time.This medicine absorbs fully, onset is rapid, and angina pectoris symptom is alleviated, and electrocardiogram is improved rapidly.
Since nineteen ninety-two, we adopt counter point, i.e. and treatment group (Jiuxin Yidiling liquid medicine for curing heart disease, each 10-15 drips, splash in the oral cavity) and matched group (SUXIAO JIUXIN WAN 10-15 grain, sublingual administration) treat angina pectoris (all examine and be angina pectoris) 120 examples, 62 examples respectively by the WHO diagnostic criteria.The result shows; Paresthesia alleviateding time: alleviate 84 examples (accounting for 70%), 3-5 in the treatment group 2 minutes and minute alleviate 26 examples (21.6%), 6-10 and minute alleviate that 6 examples (5%), 11-15 minute are alleviated 2 examples (1.6%), 2 examples are invalid, total effective rate 98.3%.Slow 0 example in the matched group 2 minutes, 3-5 minute are alleviated 7 examples (11.2%), 6-10 and minute are alleviated that 21 examples (33.8%), 11-15 minute are alleviated 29 examples (46.7%), 5 examples are invalid, total effective rate 91.9%.Electrocardiogram improves situation (the improvement standard: ST section rise that moves down or raise or decline＞0.1MV or recovery are normal), the treatment group is improved 16 examples (13.3%)＞0.1MV or is recovered normal in 2 minutes), the treatment group was improved 16 examples (13.3%), 3-5 minute 47 examples (39.1%), 6-10 minute 5 examples (4.1%), 11-15 minute 0 example, improvement rate always 56.6% in 2 minutes; Matched group: improve 0 example, 3-5 minute 6 examples (9.6%), 6-10 minute 10 examples (16.1%), 11-15 minute 11 examples (17.7%), improvement rate always 43.5% in 2 minutes.Remission rate, electrocardiogram improvement rate treatment group are better than matched group,
Paresthesia alleviateding time improves the chronotherapy group with electrocardiogram and compares obvious shortening (P＜0.01) with matched group.
The present invention implements like this, earlier with Rhizoma Chuanxiong 25g, Radix Salviae Miltiorrhizae 25g, soaked 15 days among the edible wine 100ml of adding 50-75%, then immersion is leached, again Styrax 2.5g, Moschus 0.1g are added molten 24 hours after-filtration in the immersion, filtrate is added Borneolum Syntheticum 5g dissolve, standby in the drop bottle of packing into special.
Claims (2)
1, a kind of Chinese Traditional Medicines " Jiuxin Yidiling liquid medicine for curing heart disease ", its Chinese medicinal ingredients comprises Rhizoma Chuanxiong, Borneolum Syntheticum, Styrax, Radix Salviae Miltiorrhizae, Moschus, its composition ratio is: Rhizoma Chuanxiong 25g, Radix Salviae Miltiorrhizae 25g, Styrax 2.5g, Moschus 0.1g, Borneolum Syntheticum 5g, 50-75% contain and use ethanol 100ml.
2, Chinese Traditional Medicines according to claim 1 " Jiuxin Yidiling liquid medicine for curing heart disease " is characterized in that this medicine is a liquid drops.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95100615 CN1110173A (en) | 1995-01-27 | 1995-01-27 | Jiuxin Yidiling liquid medicine for curing heart disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95100615 CN1110173A (en) | 1995-01-27 | 1995-01-27 | Jiuxin Yidiling liquid medicine for curing heart disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1110173A true CN1110173A (en) | 1995-10-18 |
Family
ID=5073539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95100615 Pending CN1110173A (en) | 1995-01-27 | 1995-01-27 | Jiuxin Yidiling liquid medicine for curing heart disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1110173A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297288C (en) * | 2003-11-19 | 2007-01-31 | 王锦刚 | Medicine for treating cardiovascular disease, and its prepn. method |
| CN1778347B (en) * | 2004-11-26 | 2010-05-12 | 天津天士力制药股份有限公司 | A kind of traditional Chinese medicine dripping pill for treating coronary heart disease |
| CN103610936A (en) * | 2013-12-13 | 2014-03-05 | 赵中海 | Chinese medicinal preparation for treating coronary heart disease and preparation method thereof |
| CN104107219B (en) * | 2014-07-18 | 2018-07-27 | 长春中医药大学 | A kind of aerosol and its preparation process for treating coronary disease and angina pectoris |
| CN109260260A (en) * | 2018-11-21 | 2019-01-25 | 青海晶珠藏药高新技术产业股份有限公司 | Medicine for treating coronary heart disease angina pectoris and preparation method thereof |
| CN117243989A (en) * | 2023-09-26 | 2023-12-19 | 上海市中医医院 | An external traditional Chinese medicine composition for treating coronary heart disease and its application |
-
1995
- 1995-01-27 CN CN 95100615 patent/CN1110173A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297288C (en) * | 2003-11-19 | 2007-01-31 | 王锦刚 | Medicine for treating cardiovascular disease, and its prepn. method |
| CN1778347B (en) * | 2004-11-26 | 2010-05-12 | 天津天士力制药股份有限公司 | A kind of traditional Chinese medicine dripping pill for treating coronary heart disease |
| CN103610936A (en) * | 2013-12-13 | 2014-03-05 | 赵中海 | Chinese medicinal preparation for treating coronary heart disease and preparation method thereof |
| CN104107219B (en) * | 2014-07-18 | 2018-07-27 | 长春中医药大学 | A kind of aerosol and its preparation process for treating coronary disease and angina pectoris |
| CN109260260A (en) * | 2018-11-21 | 2019-01-25 | 青海晶珠藏药高新技术产业股份有限公司 | Medicine for treating coronary heart disease angina pectoris and preparation method thereof |
| CN115006444A (en) * | 2018-11-21 | 2022-09-06 | 青海晶珠藏药高新技术产业股份有限公司 | Medicine for treating coronary heart disease and angina pectoris and preparation method thereof |
| CN117243989A (en) * | 2023-09-26 | 2023-12-19 | 上海市中医医院 | An external traditional Chinese medicine composition for treating coronary heart disease and its application |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |