CN110749740A - Sample analyzer and cleaning method thereof - Google Patents

Abstract

The present application discloses a sample analysis device and a cleaning method thereof. The device includes: a controller, a sample providing sub-device, a detection sub-device, and a cleaning liquid storage sub-device; the controller is respectively connected with the sample providing sub-device and the The detection sub-device is connected, the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the detection sub-device under the control of the controller to the detection sub-device The sample to be detected is provided for its detection or the cleaning solution in the cleaning solution storage sub-device is provided to the detection sub-device for cleaning under the control of the controller. Through the above method, the present application can realize automatic cleaning, the process is simple, and the structural components of the sample analysis device can be reused to make the structure compact.

Description

Sample analysis device and cleaning method thereof

technical field

The present application relates to the technical field of immunoassays, and in particular, to a sample analysis device and a cleaning method thereof.

Background technique

The sample analysis device is a common analysis instrument in the field of in vitro diagnostic medical devices, and is generally used to detect and analyze samples such as blood samples or body fluids. The sample analysis device may include multiple detection items.

Usually, each analysis sub-device or detector component of the sample analysis device needs to be cleaned and maintained with a daily cleaning solution, so as to ensure the accuracy of the detection result and the service life of each device component. In the prior art, the routine maintenance of the sample analysis device is generally performed by manually opening the bottle mouth of the cleaning solution storage sub-device and placing it at the sampling position, and then clicking the button. , and perform cleaning of each detector part or the whole machine with cleaning solution. There are also some manufacturers of sample analysis devices that manually place the cleaning solution storage sub-device in an automatic sampling device, and the cleaning solution storage sub-device is transported to the inside of the device through the automatic sampling device. Perform cleaning. Since this method needs to add an automatic sampling device for transporting the cleaning liquid storage sub-device, the cost of the instrument is increased; and the user is still required to put the cleaning liquid in the automatic sampling device every day, which increases the user's operation.

In the long-term research and development process, the inventors of the present application found that, on the one hand, the above-mentioned cleaning operation increases the manual operation, and the process is relatively complicated.

SUMMARY OF THE INVENTION

The main technical problem to be solved by the present application is to provide a sample analysis device and a cleaning method thereof, which can realize automatic cleaning, the process is simple, the manual operation is reduced, the cost is low, and the structural components of the sample analysis device are reused, so that the It is compact and reduces the impact of cleaning fluid on other components in the analyzer.

In order to solve the above technical problem, a technical solution adopted in the present application is to provide a sample analysis device, the device includes a detection sub-device, and further includes: a controller, a sample providing sub-device and a cleaning liquid storage sub-device; the control The sampler is connected to the sample providing sub-device and the detection sub-device respectively, the sample providing sub-device is respectively connected to the detection sub-device and the cleaning liquid storage sub-device; the sample providing sub-device is in the control Under the control of the controller, a sample to be detected can be provided to the detection sub-device for its detection, or the cleaning liquid in the cleaning liquid storage sub-device can be provided to the detection sub-device for its detection under the control of the controller. cleaning.

In order to solve the above technical problem, another technical solution adopted in the present application is to provide a cleaning method for a sample analysis device, the method is applicable to the above-mentioned sample analysis device, and the method includes: receiving a cleaning instruction; The cleaning instruction is used to control the sample providing sub-device to provide the cleaning solution in the cleaning solution storage sub-device to the detection sub-device for cleaning.

The beneficial effects of the present application are: different from the situation in the prior art, the device of the present application includes: a controller, a sample providing sub-device, a detection sub-device and a cleaning liquid storage sub-device; the controller and the sample providing sub-device are respectively connected with the detection sub-device, the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the detection sub-device under the control of the controller The sub-device provides a sample to be detected for its detection or provides the cleaning solution in the cleaning solution storage sub-device to the detection sub-device for cleaning under the control of the controller. The sample providing sub-device can provide the sample to be detected to the detection sub-device, and under the control of the controller, the cleaning liquid in the cleaning liquid storage sub-device can also be automatically provided to the detection sub-device for cleaning. In this way, a On the one hand, automatic cleaning can be realized, the process is simple, the manual operation is reduced, and the cost is low; Effects of other components within the analyzer.

Description of drawings

In order to illustrate the technical solutions in the embodiments of the present application more clearly, the following briefly introduces the drawings that are used in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort. in:

FIG. 1 is a schematic structural diagram of an embodiment of the sample analysis device of the present application;

2 is a schematic structural diagram of another embodiment of the sample analysis device of the present application;

FIG. 3 is a schematic structural diagram of another embodiment of the sample analysis device of the present application;

4 is a schematic structural diagram of another embodiment of the sample analysis device of the present application;

FIG. 5 is a schematic structural diagram of another embodiment of the sample analysis device of the present application;

6 is a schematic flowchart of an embodiment of the cleaning method of the sample analysis device of the present application;

FIG. 7 is a schematic flowchart of another embodiment of the cleaning method of the sample analysis device of the present application.

Detailed ways

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

Referring to FIG. 1 , FIG. 1 is a schematic structural diagram of an embodiment of the sample analysis device of the present application. The device includes: a controller 1 , a sample providing sub-device 2 , a detection sub-device 3 and a cleaning solution storage sub-device 4 .

The controller 1 is respectively connected to the sample providing sub-device 2 and the detection sub-device 3, and the sample providing sub-device 2 is respectively connected to the detection sub-device 3 and the cleaning solution storage sub-device 4; the sample providing sub-device 2 is controlled by the controller 1 Then, the sample to be detected can be provided to the detection sub-device 3 for its detection, or the cleaning solution in the cleaning solution storage sub-device 4 can be provided to the detection sub-device 3 for cleaning under the control of the controller 1 .

The sample analysis device may be any device for analyzing or detecting or manipulating the sample to be detected, such as: an immunoassay device, a blood cell analysis device, a biochemical analysis device, and the like.

In this embodiment, the sample providing sub-device 2 is mainly used to provide the sample to be detected to the detection sub-device 3. After the detection sub-device 3 is detected, in addition to cleaning with a general conventional cleaning solution, it also needs to be cleaned with a cleaning solution periodically. , in order not to add redundant structural components as much as possible, the sample providing sub-device 2 is also connected with the cleaning liquid storage sub-device 4, and under the control of the controller 1, the sample providing sub-device 2 is further made to store the cleaning liquid storage sub-device 4. The cleaning liquid in the test sub-device 3 is provided to the detection sub-device 3 for cleaning.

The device of the embodiment of the present application includes: a controller 1, a sample providing sub-device 2, a detection sub-device 3, and a cleaning solution storage sub-device 4; the controller 1 is respectively connected with the sample providing sub-device 2 and the detection sub-device 3 is connected, the sample providing sub-device 2 is respectively connected with the detection sub-device 3 and the cleaning solution storage sub-device 4; The sub-device 3 provides the sample to be detected for its detection or provides the cleaning solution in the cleaning solution storage sub-device 4 to the detection sub-device 3 for cleaning under the control of the controller 1 . The sample providing sub-device 2 can provide the sample to be detected to the detection sub-device 3, and under the control of the controller 1, it can also automatically provide the cleaning solution in the cleaning solution storage sub-device 4 to the detection sub-device 3 for cleaning. In this way, on the one hand, automatic cleaning can be realized, manual operations are reduced, and the process is simple; Since the sample supply sub-device is used to directly absorb the liquid in the cleaning liquid storage sub-device, there is no need to add an additional cleaning liquid supply pipeline, which reduces the cost, and also reduces the corrosion and interference of the cleaning liquid to the valves and other components flowing through the pipeline. the life of the sample analyzer components.

2, in one embodiment, the sample providing sub-device 2 includes: a sampling needle 21, a driving assembly 22, a valve 23 and a pipeline 24, the sampling needle 21 and the pipeline 24 are connected, and the driving assembly 22 and the valve 23 are arranged in the pipeline On road 24. Wherein, the drive assembly 22 and the valve 23 are respectively connected with the controller 1 .

Further, referring to FIG. 3 , the driving assembly 22 includes a horizontal motor subassembly 221 , a vertical motor subassembly 222 and a driving motor 223 , and the horizontal motor subassembly 221 and the vertical motor subassembly 222 are respectively connected with the driving motor 223 . The drive motor 223 is connected to the controller 1 .

The horizontal motor subassembly 221 controls the sampling needle 21 to move in the horizontal direction, and the path of the horizontal motor subassembly 221 is a straight line, a curve or a circle; the vertical motor subassembly 222 controls the sampling needle 21 to move in the vertical direction.

The sampling needle 21 of the sample providing sub-device 2 sucks the sample to be detected from outside the machine under the control of the controller 1, and then operates under the control of the horizontal motor sub-assembly 221 and the vertical motor sub-assembly 222 respectively to provide the sample to be detected. To the detection sub-device 3.

In one embodiment, the diameter of the bottle mouth of the cleaning liquid storage sub-device 4 is smaller than or equal to a predetermined diameter; the predetermined diameter needs to be as unfavorable as possible to volatilize the cleaning liquid. In order to further reduce the volatilization of the cleaning liquid, the bottle mouth of the cleaning liquid storage sub-device 4 is provided with a sealing material; the cleaning liquid storage sub-device 4 is arranged on the walking path of the sampling needle 21 . Since the sampling needle 21 of the sample providing sub-device 2 needs to absorb the cleaning liquid from the cleaning liquid storage sub-device 4 under the control of the controller 1, the cleaning liquid storage sub-device 4 is arranged on the walking path of the sampling needle 21, which is convenient on the one hand. The sampling needle 21 sucks, on the other hand, the structure of the sample analysis device can be made as compact as possible, and the occupied space is as small as possible.

Wherein, under the control of the controller 1, the sampling needle 21 runs to the bottle mouth of the cleaning liquid storage sub-device 4, punctures and absorbs the cleaning liquid, and delivers the cleaning liquid to the detection sub-device 3 for cleaning. The sampling needle 21 absorbs the cleaning liquid by puncturing, which can further prevent and reduce the volatilization of the cleaning liquid.

In one embodiment, the detection sub-devices 3 are used to detect blood routine items on the samples to be detected or to detect immune protein items on the samples to be detected; the number of detection sub-devices 3 is more than one, such as 2, 3 or 4. The detection sub-device 3 is arranged on the walking path of the sampling needle 21 . For example, referring to FIG. 4 , the number of detection sub-devices 3 includes three.

5, in one embodiment, the device further includes a cleaning button 5, which is electrically connected to the controller 1, and when the cleaning button 5 is triggered to issue a trigger signal, the controller 1 responds to the trigger signal to control the sample to provide The sub-device 2 provides the cleaning solution in the cleaning solution storage sub-device 4 to the detection sub-device 3 for cleaning.

By arranging the cleaning button 5 , it is convenient for the user to operate. When the detection sub-device 3 needs to be cleaned, it is only necessary to press the cleaning button 5 to trigger and generate a trigger signal. The setting position of the cleaning button 5 is not limited, as long as it is convenient for the user to operate.

In another embodiment, the controller 1 is further configured to receive a cleaning command, and in response to the cleaning command, control the sample providing sub-device 2 to provide the cleaning solution in the cleaning solution storage sub-device 4 to the designated detection sub-device 3 for cleaning , and after the cleaning is completed, control the designated detection sub-device 3 to shut down.

Referring to FIG. 6, FIG. 6 is a schematic flowchart of an embodiment of the cleaning method of the sample analysis device of the present application. The method is applicable to the sample analysis device of any one of the above. For a detailed description of the relevant content, please refer to the above method section, which is not repeated here. Repeat. The method includes:

Step S101: Receive a cleaning instruction.

Step S102: In response to the cleaning instruction, the sample providing sub-device is controlled to provide the cleaning solution in the cleaning solution storage sub-device to the detection sub-device for cleaning.

In the embodiment of the present application, the sample providing sub-device can provide the sample to be detected to the detection sub-device, and under the control of the controller, the cleaning liquid in the cleaning liquid storage sub-device can also be automatically provided to the detection sub-device for cleaning. In this way, on the one hand, automatic cleaning can be realized, and the process is simple;

The cleaning instruction includes a designated detection sub-device that needs to be cleaned; the cleaning instruction also includes shutting down after cleaning. The cleaning instruction can be generated by setting the cleaning button and triggered by the user's click, or generated by the user through input through another input sub-device.

7 , in step S102 , the sample providing sub-device is controlled to provide the cleaning solution in the cleaning solution storage sub-device to the detection sub-device for cleaning, which may specifically include: sub-step S1021 , sub-step S1022 and sub-step S1023 .

Sub-step S1021: Control the sampling needle of the sample providing sub-device to move to the position of the cleaning solution storage sub-device and suck the cleaning solution.

Sub-step S1022: Control the movement of the sampling needle and deliver the cleaning solution to the designated detection sub-device.

Sub-step S1023: Control and execute cleaning of the device components of the designated detection sub-device.

The cleaning method of the present application reduces the number of operations for manually placing the cleaning liquid storage sub-device at the sampling position, and only needs to click the cleaning button to perform cleaning of each device component. The one-button operation process simplifies user operations and improves user experience, and the cleaning effect is reliable.

The above description is only an embodiment of the present application, and is not intended to limit the scope of the patent of the present application. Any equivalent structure or equivalent process transformation made by using the contents of the description and drawings of the present application, or directly or indirectly applied to other related technologies Fields are similarly included within the scope of patent protection of this application.

Claims (13)

1. A sample analysis device, the device comprising a detection sub-device, characterized in that the device further comprises: a controller, a sample providing sub-assembly and a cleaning fluid storage sub-assembly; the controller is respectively connected with the sample providing sub-device and the detection sub-device, and the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the sample to be detected to the detecting sub-device under the control of the controller or provide the cleaning liquid in the cleaning liquid storing sub-device to the detecting sub-device for cleaning under the control of the controller.

2. The apparatus of claim 1, wherein the sample providing sub-apparatus comprises: sampling needle, drive assembly, valve and pipeline, the sampling needle with the tube coupling, drive assembly with the valve setting is in on the pipeline.

3. The apparatus of claim 2, wherein the drive assembly comprises: the motor comprises a horizontal motor subassembly, a vertical motor subassembly and a driving motor, wherein the horizontal motor subassembly and the vertical motor subassembly are respectively connected with the driving motor.

4. The device of claim 3, wherein the horizontal motor subassembly controls the sampling needle to move in a horizontal direction, and the path traveled by the horizontal motor subassembly is a straight line, a curve or a circle; the vertical motor subassembly controls the sampling needle to move in the vertical direction.

5. The apparatus of claim 4, wherein the sampling needle of the sample providing sub-apparatus is controlled by the controller to take a sample to be tested from outside, and then operated under the control of the horizontal motor sub-assembly and the vertical motor sub-assembly to provide the sample to be tested to the testing sub-apparatus.

6. The device of claim 2, wherein the diameter of the mouth of the cleaning solution storage sub-device is less than or equal to a preset diameter; a bottle opening of the cleaning solution storage sub-device is provided with a sealing rubber material; the cleaning liquid storage sub-device is arranged on a walking path of the sampling needle.

7. The device of claim 6, wherein the sampling needle runs to the mouth of the cleaning liquid storage sub-device and punctures to suck the cleaning liquid and deliver the cleaning liquid to the detection sub-device to perform cleaning under the control of the controller.

8. The device according to claim 2, wherein the detection sub-device is used for detecting a blood routine item or an immune protein item of a sample to be detected; the number of the detection sub-devices is more than one; the detection sub-device is arranged on a walking path of the sampling needle.

9. The device of claim 1, further comprising a cleaning button electrically connected to the controller, wherein when the cleaning button is activated to generate a trigger signal, the controller controls the sample providing sub-device to provide the cleaning solution in the cleaning solution storage sub-device to the detecting sub-device for cleaning thereof in response to the trigger signal.

10. The apparatus of claim 1, wherein the controller is further configured to receive a wash command, control the sample providing sub-apparatus to provide the cleaning liquid in the cleaning liquid storage sub-apparatus to a designated detecting sub-apparatus for washing in response to the wash command, and control the designated detecting sub-apparatus to shut down after washing is completed.

11. A method of cleaning a sample analysis device, the method being adapted for use with a sample analysis device according to any one of claims 1 to 10, the method comprising:

receiving a cleaning instruction;

in response to the washing instruction, the sample providing sub-device is controlled to provide the cleaning liquid in the cleaning liquid storage sub-device to the detecting sub-device for washing thereof.

12. The method of claim 11, wherein the cleaning instructions include a designated detection sub-device requiring cleaning; the cleaning instruction further comprises shutdown after cleaning is finished.

13. The method of claim 12, wherein said controlling said sample providing sub-assembly to provide cleaning fluid in said cleaning fluid storage sub-assembly to said detection sub-assembly for cleaning thereof comprises:

controlling the sampling needle of the sample providing sub-device to move to the position of the cleaning liquid storage sub-device and suck the cleaning liquid;

controlling the sampling needle to move and conveying the cleaning liquid to a designated detection sub-device;

and controlling and executing the cleaning of the device parts of the designated detection sub-device.

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