CN110292890A - A kind of pharmaceutical preparation intelligent agitating device and its application - Google Patents
A kind of pharmaceutical preparation intelligent agitating device and its application Download PDFInfo
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- CN110292890A CN110292890A CN201910587793.4A CN201910587793A CN110292890A CN 110292890 A CN110292890 A CN 110292890A CN 201910587793 A CN201910587793 A CN 201910587793A CN 110292890 A CN110292890 A CN 110292890A
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- agitating device
- stirring
- motor
- pharmaceutical preparation
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- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 62
- 239000006071 cream Substances 0.000 claims abstract description 33
- 238000002360 preparation method Methods 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 10
- 230000008569 process Effects 0.000 claims abstract description 6
- 230000008859 change Effects 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 210000003022 colostrum Anatomy 0.000 claims description 18
- 235000021277 colostrum Nutrition 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 6
- 235000004237 Crocus Nutrition 0.000 claims description 5
- 241000596148 Crocus Species 0.000 claims description 5
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 5
- 239000004202 carbamide Substances 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 229940057995 liquid paraffin Drugs 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
- 229950008882 polysorbate Drugs 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 229940075582 sorbic acid Drugs 0.000 claims description 5
- 235000010199 sorbic acid Nutrition 0.000 claims description 5
- 239000004334 sorbic acid Substances 0.000 claims description 5
- 239000008117 stearic acid Substances 0.000 claims description 5
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 230000003028 elevating effect Effects 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 4
- 230000003014 reinforcing effect Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000001587 sorbitan monostearate Substances 0.000 claims description 2
- 229940035048 sorbitan monostearate Drugs 0.000 claims description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 13
- 230000000052 comparative effect Effects 0.000 description 9
- 239000002023 wood Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 5
- 230000007704 transition Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101100521345 Mus musculus Prop1 gene Proteins 0.000 description 1
- 108700017836 Prophet of Pit-1 Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/212—Measuring of the driving system data, e.g. torque, speed or power data
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
- B01F35/41—Mounting or supporting stirrer shafts or stirrer units on receptacles
- B01F35/411—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft
- B01F35/4111—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft at the top of the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P70/00—Climate change mitigation technologies in the production process for final industrial or consumer products
- Y02P70/10—Greenhouse gas [GHG] capture, material saving, heat recovery or other energy efficient measures, e.g. motor control, characterised by manufacturing processes, e.g. for rolling metal or metal working
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dairy Products (AREA)
Abstract
The invention discloses a kind of pharmaceutical preparations to be equipped with variable-frequency motor with intelligent agitating device, including frame body, frame body, and the motor shaft of motor is connected with dynamic torque sensor, and dynamic torque sensor has stirring connecting rod, and stirring connecting rod lower part is equipped with the double-deck stirring blade.By setting motor and dynamic torque sensor, the case where detecting resistance according to torque sensor, the speed for reducing motor prevents from splashing, and increases the dynamics of motor rotation, allow motor can according to the rotary speed working of regulation, allow preparation stirring more evenly.The agitating device also can be set as needed the time point of electrical motor gearshift, at corresponding time point, change velocity mode.The present invention also provides the applications of intelligent agitating device of said medicine preparation, in the preparation process of cream, stir the quality that process improves cream by intelligent control.
Description
Technical field
The present invention relates to a kind of agitating device more particularly to a kind of pharmaceutical preparation intelligent agitating device and its applications.
Background technique
Currently, during hospital preparation, to being frequently necessary in the preparation process of pharmaceutical formulation through stirring be drug
It is uniformly mixed, traditional mixed method is used and is manually stirred, but is difficult to ensure that drug is sufficiently mixed in this way, and in medicine
Mixing efficiency is low in the biggish situation of object amount, large labor intensity, not smart enoughization.Can not make in whipping process drug with it is molten
Liquid stirs, and the drug after stirring can generate a large amount of foams and the dregs of a decoction, and very big noise is had in whipping process, can damage
Hurt the ear-drum of surrounding staff, also will affect the quality of life of surrounding resident, when stirring, which generates sharp pounding, can reduce stirring
The service life of device.
The ointment made of emulsion-type matrix claims cream.Cream is not easy to melt, uniformly, it is fine and smooth, and have appropriate
Vicidity is easy to coated on skin or mucous membrane, and main rise protects the surface of a wound, greasy skin and local therapeutic effects, some drugs
Also systemic therapy effect can be generated after percutaneous absorbtion.With the continuous development of medical science, the new matrix and skin of cream are pacified
The further investigation of full property, the continuous improvement of preparation method make the quality of cream obtain large increase.But existing cream
The preparation method of paste has the following deficiencies: that the cream stability of preparation is poor, and consistency is low, sophistication is relatively thick and tries cold-resistant
There is water-oil separating phenomenon in testing, brings inconvenience to the use of cream.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of intelligence stirrings of pharmaceutical preparation
The characteristics of device has structure simple, easy to use, submits production efficiency.
The second object of the present invention is to provide a kind of application of intelligent agitating device of said medicine preparation.
An object of the present invention adopts the following technical scheme that realization:
A kind of pharmaceutical preparation intelligent agitating device, including frame body, the frame body are equipped with variable ratio frequency changer motor, the motor
Motor shaft be connected with dynamic torque sensor, the dynamic torque sensor has a stirring connecting rod, under the stirring connecting rod
Portion is equipped with stirring twi-tier blade.
Further, Worm and screw elevating mechanism is equipped between the dynamic torque sensor and stirring connecting rod.
Further, the variable ratio frequency changer motor is single-phase frequency control motor.
Further, the single-phase frequency control motor is connected with intelligent controller.
Further, the frame body includes tripod, the support base being located on tripod, between the supporting leg of the tripod
Reinforcing rib equipped with circular ring shape.
Further, the stirring twi-tier blade is that five blades stir twi-tier blade, three, upper layer blade, two leaves of lower layer
Piece.
The second object of the present invention adopts the following technical scheme that realization:
The application of the intelligent agitating device of said medicine preparation, in the preparation process of cream.
Further, the preparation process of the cream is as follows
(1) match liquefaction phase: taking stearic acid, albolene, liquid paraffin, octadecyl alcolol, sorbitan monostearate, heat
Fusing, is filtered with crocus cloth, and filtrate keeps the temperature in 70 DEG C, spare
(2) it prepares water phase: taking urea that distilled water is added to dissolve, mixed with glycerol, polysorbate, sorbic acid, be heated to 70-75
It is DEG C spare；
(3) oily phase is slowly added to 40% water phase under the stirring of intelligent agitating device 400-410r/min,
400r/min is stirred to w/o type colostrum and is formed；
(4) after the colostrum of step (3) is cooling, increase mixing speed to 700-710r/min, by the water phase of residue 60%
It is added, colostrum is made to be transformed into O/W type emulsion；
(5) mixing speed is gradually decreased to 300-310r/min, continues to complete after stirring a period of time.
Further, when colostrum is cooled to 65-70 DEG C in the step (4), increase mixing speed to 700r/min.
Further, the middle stirring of above-mentioned steps (5) is down to 50 DEG C to temperature and is got product.
It is added in oily phase in batches by controlling water phase, and different mixing speed and temperature is set, it is such as first in preparation
When newborn, initial stage is mixed, control mixing speed is 400-410r/min, and stirring initially forms the transoid emulsion of w/o type, is constantly being added
In the case where entering water phase, improves mixing speed and turned to 700-710r/min so that transoid emulsion makes the transition rapidly by w/o type
For O/W type；Mixing speed is down to 300-310r/min after transition, in order to avoid because mixing speed is too fast, mixing time is too long, and make
It brings excessive air in cream into, generate bubble, the quality and stability of cream is influenced, when cream temperature is down to 50 DEG C
When should stop stirring, should not stir to total condensation, with prevent cream by excessive agitation cut and make its consistency reduction.
Compared with prior art, the beneficial effects of the present invention are: the present invention to provide a kind of pharmaceutical preparation intelligently stirring dress
It sets, by the way that variable-frequency motor and dynamic torque sensor is arranged, the case where resistance is detected according to torque sensor, reduces motor
Speed prevent from splashing, increase motor rotation dynamics, allow preparation stirring more evenly intelligence.This agitating device can also be according to every
The formula of the different preparations of kind, sets the time point of electrical motor gearshift, at corresponding time point, changes velocity mode.The agitating device
Also have the function of preventing locking, when preparation vessels internal resistance is excessive, or encounters foreign matter, can actively shut down, and intelligently remember
The progress for recording agent configuration, continues to complete remaining work after fault recovery.The present invention also provides said medicine preparation use
The application of intelligent agitating device stirs the product that process improves cream by intelligent control in the preparation process of cream
Matter.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the intelligent agitating device of pharmaceutical preparation of the present invention；
In figure: 1, tripod；2, support base；3, motor；4, intelligent controller；5, dynamic torque sensor；6, stirring connects
Bar；7, stirring blade；8, Worm and screw elevating mechanism；9, container；10, reinforcing rib.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
Embodiment 1
The intelligent agitating device of a kind of pharmaceutical preparation as shown in Figure 1:, including frame body, frame body include tripod 1, are located at three
Support base 2 on foot prop 1 is equipped with the reinforcing rib of circular ring shape between the supporting leg of tripod, increases the stabilization of equipment using tripod 1
Property.Support base 2 is equipped with motor 3, it is preferred that motor 3 is single-phase frequency control motor.Single-phase frequency control motor and intelligence control
Device 4 processed is connected, which can control speed and the duty cycle of motor 3.
The motor shaft of motor 3 is connected with dynamic torque sensor 5, and dynamic torque sensor 5 can be monitored in real time stirring and meet
The drag size arrived, according to monitoring data, intelligent controller 4 adjusts the revolving speed of motor 3, prevents in whipping process because of mixing speed
Liquid splash caused by too fast or the excessively slow caused mixing of mixing speed are uneven.
Dynamic torque sensor 5 has stirring connecting rod 6, and stirring 6 lower part of connecting rod is equipped with stirring twi-tier blade 7, paddle
Piece 7 is located at stirring in container 9.Preferably stainless steel material, stirring blade 7 are that five blades stir twi-tier blade, upper layer three
A blade, two blades of lower layer.It is equipped with Worm and screw elevating mechanism 8 between dynamic torque sensor 5 and stirring connecting rod 6, allows and stirs
It mixes blade 7 to move up and down in liquid, forms vortex, preparation is allowed to stir more evenly.
The present invention provides a kind of intelligent agitating device of pharmaceutical preparation, and motor 3 and dynamic torque sensor 5 is arranged, according to
Torque sensor 5 detects the case where resistance, and the speed for reducing motor 3 prevents from splashing, and increases the dynamics that motor 3 rotates, allows preparation
Stirring is more evenly.The agitating device can also set the time point of 3 speed change of motor, in phase according to the formula of every kind of different preparations
The time point answered changes velocity mode.The agitating device also has the function of preventing locking, when preparation vessels internal resistance is excessive,
It or when encountering foreign matter, can actively shut down, and the intelligently progress of record preparation configuration, be continued to complete after fault recovery remaining
Work.
Embodiment 2
The application of the intelligent agitating device of said medicine preparation, in the preparation process of cream, comprising the following steps:
(1) match liquefaction phase: taking stearic acid 60g, albolene 60g, liquid paraffin 90g, octadecyl alcolol 60g, anhydro sorbitol
Stearate 16g, heating fusing, is filtered with crocus cloth, and filtrate keeps the temperature in 70 DEG C, spare；
(2) it prepares water phase: taking urea 150g that appropriate distilled water is added to dissolve, with glycerol 100g, polysorbate 44g, sorbic acid
2g mixing, be heated to 70-75 DEG C it is spare；
(3) oily phase is slowly added to 40% water phase under the stirring of intelligent agitating device 400r/min, stirring is extremely
W/o type colostrum is formed；
(4) colostrum to step (3) is cooled to 65-70 DEG C, increases mixing speed to 700r/min, by the water of residue 60%
It is added to, colostrum is made to be transformed into O/W type emulsion；
(5) mixing speed is gradually decreased to 300r/min, continues stirring and is down to 50 DEG C to temperature and gets product.
Embodiment 3
The application of the intelligent agitating device of said medicine preparation, in the preparation process of cream, comprising the following steps:
(1) match liquefaction phase: taking stearic acid 60g, albolene 60g, liquid paraffin 90g, octadecyl alcolol 60g, anhydro sorbitol
Stearate 16g, heating fusing, is filtered with crocus cloth, and filtrate keeps the temperature in 70 DEG C, spare；
(2) it prepares water phase: taking urea 150g that appropriate distilled water is added to dissolve, with glycerol 100g, polysorbate 44g, sorbic acid
2g mixing, be heated to 70 DEG C it is spare；
(3) oily phase is slowly added to 40% water phase under the stirring of intelligent agitating device 405r/min, stirring is extremely
W/o type colostrum is formed；
(4) colostrum to step (3) is cooled to 65 DEG C, increases mixing speed to 705r/min, by the water phase of residue 60%
It is added, colostrum is made to be transformed into O/W type emulsion；
(5) mixing speed is gradually decreased to 305r/min, continues stirring and is down to 50 DEG C to temperature and gets product.
Embodiment 4
The application of the intelligent agitating device of said medicine preparation, in the preparation process of cream, comprising the following steps:
(1) match liquefaction phase: taking stearic acid 60g, albolene 60g, liquid paraffin 90g, octadecyl alcolol 60g, anhydro sorbitol
Stearate 16g, heating fusing, is filtered with crocus cloth, and filtrate keeps the temperature in 70 DEG C, spare；
(2) it prepares water phase: taking urea 150g that appropriate distilled water is added to dissolve, with glycerol 100g, polysorbate 44g, sorbic acid
2g mixing, be heated to 75 DEG C it is spare；
(3) oily phase is slowly added to 40% water phase under the stirring of intelligent agitating device 410r/min, stirring is extremely
W/o type colostrum is formed；
(4) colostrum to step (3) is cooled to 70 DEG C, increases mixing speed to 710r/min, by the water phase of residue 60%
It is added, colostrum is made to be transformed into O/W type emulsion；
(5) mixing speed is gradually decreased to 310r/min, continues stirring and is down to 50 DEG C to temperature and gets product.
Comparative example 1
Comparative example 1 provides a kind of preparation method of cream, using general stirring apparatus: stirring of the water phase in 300r/min
Under, oil is mutually slowly added into water phase, and be stirred continuously to 35 DEG C of creams and condense, is dispensed to obtain the final product.
Test example
Using 2015 editions VII methods of " Pharmacopoeia of People's Republic of China one " annex, embodiment 1 and comparative example 1 are measured
The relative density of cream, and sample moisture content is measured, it is that evaluation index synthesis is commented with appearance character, mobility, hardness, mouthfeel
Point, the results are shown in Table 1.
1. experimental facilities: electronic balance, Constant Temp. Oven, red copper pot, portable sterilizing pan, hundred grades of clean work
Platform.
2. moisture determination
The cream for taking 10 grams of embodiments 1 and comparative example 1 to prepare respectively, is laid in the weighing disk of constant weight, opens bottle cap,
It sets in 100~105 DEG C of thermostatic drying chamber, bottle cap is covered, moved in drier by dry 5h, cooling 30min；It is accurately weighed
Weight calculates water content.
3. fluidity determining
It is provoked with wood chip, is flowed down in thin-line-shaped, count 1 point；It is provoked with wood chip, is flowed down in broken string shape, count 3 points；It is chosen with wood chip
It rises, is flowed down in disconnected pearl, count 5 points；It is provoked with wood chip, is flowed down in pearl, count 7 points；Wood chip is provoked, and falls down " hanging flag " in the form of sheets,
10 points of meter；It is provoked with wood chip, is fallen down in block, piece threadiness, count 5 points；It is provoked with wood chip, is fallen down in bulk, count 3 points；It is chosen with wood chip
It rises, is difficult to flow down, count 1 point.
4. appearance character is evaluated and tested
Viscosity appearance character under Conventional wisdom state is counted full marks (10 points), the appearance character score value under other states,
Successively decline.
5. hardness, mouthfeel are evaluated and tested
Hardness is moderate, taste lubrication, without breeze, count full marks (10 points)；Other states, score value successively decline.
Table 1
As can be seen from Table 1, comparative example 1, will be oily mutually direct using the preparation method of the cream of common agitating device
It is added in water phase and is made, compared with using the embodiment 1 of the application method, cream relative density prepared by embodiment 1 is wanted
Higher than comparative example 1, water content is lower than comparative example 1, and the viscosity of comparative example 1 is lower, and mouthfeel has breeze sense, embodiment 1
Cream is higher than comparative example 1 in comprehensive score, illustrates cream provided by the invention, and oil is added by control water phase part batch
Xiang Zhong, and different mixing speed and temperature are arranged using intelligent agitating device, such as when preparing colostrum, mix initial stage, control
Mixing speed processed is 400-410r/min, and stirring initially forms the transoid emulsion of w/o type, in the case where being continuously added water phase,
Mixing speed preferably faster (700-710r/min), so that transoid emulsion makes the transition rapidly, switchs to O/W type by w/o type；It is making the transition
Afterwards mixing speed should slightly slow (300-310r/min), in order to avoid because mixing speed is too fast, mixing time is too long, and make band in cream
Enter excessive air, generate bubble, influences the quality and stability of cream, should stop stirring when cream temperature is down to 50 DEG C
It mixes, should not stir to total condensation, make the reduction of its consistency to prevent cream from being cut by excessive agitation.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of intelligent agitating device of pharmaceutical preparation, which is characterized in that including frame body, the frame body is equipped with variable ratio frequency changer electricity
The motor shaft of machine, the motor is connected with dynamic torque sensor, and the dynamic torque sensor has stirring connecting rod, described
It stirs connecting rod lower part and is equipped with stirring twi-tier blade.
2. the intelligent agitating device of pharmaceutical preparation according to claim 1, which is characterized in that the dynamic torque sensor and
It stirs and is equipped with Worm and screw elevating mechanism between connecting rod.
3. the intelligent agitating device of pharmaceutical preparation according to claim 1, which is characterized in that the variable ratio frequency changer motor is single-phase
Frequency control motor.
4. the intelligent agitating device of pharmaceutical preparation according to claim 3, which is characterized in that the single-phase frequency control motor
It is connected with intelligent controller.
5. the intelligent agitating device of pharmaceutical preparation according to claim 1, which is characterized in that the frame body includes tripod,
The support base being located on tripod is equipped with the reinforcing rib of circular ring shape between the supporting leg of the tripod.
6. the intelligent agitating device of pharmaceutical preparation according to claim 1, which is characterized in that the stirring twi-tier blade is five
Blade stirs twi-tier blade, and upper layer is three blades, and lower layer is two blades.
7. a kind of application of intelligent agitating device of pharmaceutical preparation as described in claim 1 to 6, which is characterized in that be used in emulsifiable paste
In the preparation process of agent.
8. the application of the intelligent agitating device of pharmaceutical preparation according to claim 7, which is characterized in that the system of the cream
Standby process is as follows
(1) match liquefaction phase: taking stearic acid, albolene, liquid paraffin, octadecyl alcolol, sorbitan monostearate, heating is molten
Change, filtered with crocus cloth, filtrate keeps the temperature in 70 DEG C, spare
(2) prepare water phase: take urea that distilled water is added to dissolve, mixed with glycerol, polysorbate, sorbic acid, be heated to 70-75 DEG C it is standby
With；
(3) oily phase is slowly added to 40% water phase under the stirring of agitating device 400-410r/min, 400r/min is stirred
It mixes to w/o type colostrum and is formed；
(4) after the colostrum of step (3) is cooling, the water phase of residue 60% is added increase mixing speed to 700-710r/min,
Colostrum is set to be transformed into O/W type emulsion；
(5) mixing speed is gradually decreased to 300-310r/min, continues to complete after stirring a period of time.
9. the application of the intelligent agitating device of pharmaceutical preparation according to claim 7, which is characterized in that in the step (4)
When colostrum is cooled to 65-70 DEG C, increase mixing speed to 700r/min.
10. the application of the intelligent agitating device of pharmaceutical preparation according to claim 7, which is characterized in that in above-mentioned steps (5)
Stirring is down to 50 DEG C to temperature and is got product.
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