CN1101841A - Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof - Google Patents
Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof Download PDFInfo
- Publication number
- CN1101841A CN1101841A CN93115163A CN93115163A CN1101841A CN 1101841 A CN1101841 A CN 1101841A CN 93115163 A CN93115163 A CN 93115163A CN 93115163 A CN93115163 A CN 93115163A CN 1101841 A CN1101841 A CN 1101841A
- Authority
- CN
- China
- Prior art keywords
- guanxintong
- preparation
- chinese medicine
- rhizoma
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 61
- 206010002383 Angina Pectoris Diseases 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 11
- 230000008569 process Effects 0.000 title claims description 4
- 208000029078 coronary artery disease Diseases 0.000 title abstract description 20
- 239000008280 blood Substances 0.000 claims abstract description 33
- 210000004369 blood Anatomy 0.000 claims abstract description 33
- 238000002360 preparation method Methods 0.000 claims description 58
- 239000000243 solution Substances 0.000 claims description 23
- 239000000796 flavoring agent Substances 0.000 claims description 19
- 235000019634 flavors Nutrition 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 19
- 241000208340 Araliaceae Species 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 18
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 18
- 235000008434 ginseng Nutrition 0.000 claims description 18
- 206010062717 Increased upper airway secretion Diseases 0.000 claims description 17
- 208000026435 phlegm Diseases 0.000 claims description 17
- 235000006793 Artemisia stelleriana Nutrition 0.000 claims description 16
- 244000252230 Artemisia stelleriana Species 0.000 claims description 16
- 240000005308 Juniperus chinensis Species 0.000 claims description 16
- 235000006413 coastal sagewort Nutrition 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- 230000001105 regulatory effect Effects 0.000 claims description 16
- 238000005728 strengthening Methods 0.000 claims description 16
- 238000012856 packing Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000003809 water extraction Methods 0.000 claims description 12
- 230000000202 analgesic effect Effects 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 9
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229940126678 chinese medicines Drugs 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 8
- 238000001556 precipitation Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 238000010790 dilution Methods 0.000 claims description 4
- 239000012895 dilution Substances 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- -1 tabletting Substances 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 238000005498 polishing Methods 0.000 claims description 2
- 238000007493 shaping process Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 238000002481 ethanol extraction Methods 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 5
- 201000001320 Atherosclerosis Diseases 0.000 abstract description 4
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000029865 regulation of blood pressure Effects 0.000 abstract description 3
- 238000001035 drying Methods 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- 235000008216 herbs Nutrition 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 20
- 210000000038 chest Anatomy 0.000 description 16
- 208000002193 Pain Diseases 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 11
- 238000009472 formulation Methods 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 7
- 241001522129 Pinellia Species 0.000 description 7
- 241000545442 Radix Species 0.000 description 7
- 241001529553 Scoparia <angiosperm> Species 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000008899 fufang danshen Substances 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 241000219780 Pueraria Species 0.000 description 5
- 230000000916 dilatatory effect Effects 0.000 description 5
- 230000037396 body weight Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000004089 microcirculation Effects 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 4
- 208000031225 myocardial ischemia Diseases 0.000 description 4
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004351 coronary vessel Anatomy 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000007954 hypoxia Effects 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000153234 Hibiscus abelmoschus Species 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 229930194542 Keto Natural products 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 125000000468 ketone group Chemical group 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 244000303379 Styrax officinalis Species 0.000 description 1
- 235000001361 Styrax officinalis Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- MWOBKFYERIDQSZ-UHFFFAOYSA-N benzene;sodium Chemical compound [Na].C1=CC=CC=C1 MWOBKFYERIDQSZ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000007581 slurry coating method Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine "Guanxintong" is prepared with several Chinese medicinal herbs through washing, drying, extraction, pharmaceutics and packaging and is suitable to cure coronary heart disease and angina pectoris with effective rate up to 98.3%. Its medical functions include expansion of blood vessel, regulation of blood pressure lowering blood fat and sugar, and prevention of atherosclerosis.
Description
The present invention is a kind of Chinese medicine Guanxintong preparation of preventing and treating angina pectoris and preparation method thereof, and it belongs to the medicinal preparation of the material that derives from plant, and it comprises former medicine, cleaning, drying, extraction, preparation, packing several steps.
One class cardiovascular disease such as angina pectoris is that commonly encountered diseases, frequently-occurring disease also are difficult and complicated illness for the people more than 45 years old, is human health life-prolonging formidable enemy.Both at home and abroad medical expert, scientific research personnel, medical personnel are invariably for seeking evident in efficacy, the ideal medicament effort that side effect is little of anti-angiocardiopathy.Commercially available FUFANG DANSHEN PIAN is a main component with Borneolum Syntheticum, Radix Salviae Miltiorrhizae, Radix Notoginseng, the energy respite symptom that relieves the pain of regulating the flow of vital energy, but relatively take stopgap measures, be weaker than and effect a permanent cure, take dissipation healthy energy for a long time, and stomach is had stimulation.Among the Chinese patent publication number CN1070822A, a kind of prescription and preparation method of pulse invigorating capsule are disclosed, its purpose provides a kind of treatment coronary heart disease, anginal Chinese medicine, and its formation is to be processed into capsule with Radix Ginseng, Moschus, Semen Strychni, and its weak point is that relatively fragrance is walked to scurry, removing obstruction in the collateral to relieve pain, the strengthening the body resistance effect for reducing fat that reduces phlegm is poor, and wherein Semen Strychni is poisonous, and using must be careful, and the source shortage of Moschus medicine, cost an arm and a leg.Commercially available RENSHEN SHENGMAIYIN KOUFUYE is a key component with Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, based on QI invigorating, certain strengthening the body resistance effect is arranged, but combined therapy effect is not good enough.Therefore the control treating coronary heart disease and angina pectoris that develop a kind for the treatment of both the principal and secondary aspects of a disease, determined curative effect, taking convenience, has no side effect is desirable.
The objective of the invention is to avoid above-mentioned weak point of the prior art, and provide a kind of energy anti-, can control, have strengthening the body resistance, the chest stuffiness relieving resolving phlegm lowering turbidity, regulating the flow of QI to dissipate blood stasis pain-relieving functions concurrently, can blood vessel dilating, coronary blood flow increasing improves blood microcirculation, blood pressure regulation; Again can blood lipid-reducing blood sugar-decreasing, reduce myocardial oxygen consumption, suppress platelet aggregation, prevent or alleviate atherosclerosis, thereby understand things pain-stopping, improve immune function of human body, taking stopgap measures of enhancing body resistivity effect a permanent cure, evident in efficacy, lasting medicine, ideal coronary heart disease, the anginal Chinese medicine Guanxintong preparation prevented and treated that have no side effect.
The object of the present invention is to provide the preparation method of Guanxintong watered pill, Guanxintong powder, Guanxintong capsule, Guanxintong injection, Guanxintong electuary and the Guanxintong mixture of the taking convenience that is applicable to the different symptoms patient.
Purpose of the present invention can reach by following measure: Guanxintong preparation of the present invention is made of following component and pharmaceutical adjunct:
Strengthening the body resistance Chinese medicine 15%-50%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 20%-50%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 15%-65%
Purpose of the present invention can also reach by following measure: Guanxintong preparation preferred ingredients scope of the present invention is:
Strengthening the body resistance Chinese medicine 20%-40%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 25%-40%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 20%-45%
The compositing range of the optimum of Guanxintong preparation of the present invention is:
Strengthening the body resistance Chinese medicine 30%-40%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 30%-35%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 25%-35%
The distressed angor of coronary disease probably belongs to " thoracic obstruction " category of Chinese medicine.Chinese medicine thinks that it is that coronary disease is fallen ill originally bitterly that vigour is lost empty, and phlegm-turbidity and blood stasis blood is the mark of incidence of coronary heart disease.Along with the old and feeble of human body or because accidental causes such as other diseases, poisoning, fatigue all can be accompanied by the decline of vital organs of the human body function in the human body, be weaken all corresponding of vigor of body with immunity, cause blood supply oxygen supply deficiency, liable to illness, therefore strengthening the body resistance Chinese medicine is indispensable important component in Guanxintong preparation of the present invention; As the vitals heart of human body and the outstanding symptom of vascular system aging thereof is that myocardial contraction weakens, sclerosis of blood vessels, coronary flow reduce, acra blood vessel microcirculation worsens, in addition blood fat increase, platelet aggregation, the various symptoms of the distressed angor of coronary disease have just appearred in stagnation of QI and blood may bring about pain, so the chest stuffiness relieving reduces phlegm in Guanxintong preparation of the present invention, the turbid descending Chinese medicine is indispensable another important component; The purpose of forming the regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic introducing of Guanxintong preparation of the present invention obviously is that quick-acting relief of symptoms are removed patient suffering's purposes.Three big component giving consideration to both the incidental and fundamental, invigorating middle warmer have logical, in leading to benefit are arranged, and can alleviate disease by removing obstruction in the collateral to relieve pain, the expectorant stasis of blood that can dispel again and accumulate over a long period, the generation and the development of prevention and prevention sufferer.
Strengthening the body resistance Chinese medicine in the Guanxintong formulation components of the present invention comprises:
Radix Ginseng 10%-50%
Herba Epimedii 10%-60%
Radix Puerariae 0-50%
Radix Astragali 10%-70%
Radix Ophiopogonis 5%-55%
Fructus Schisandrae Chinensis 0-30%
The preferred compositing range of above-mentioned strengthening the body resistance Chinese medicine is:
Radix Ginseng 20%-40%
Herba Epimedii 20%-40%
Radix Puerariae 10%-30%
Radix Astragali 10%-30%
Radix Ophiopogonis 10%-30%
Fructus Schisandrae Chinensis 10%-25%
Strengthening the body resistance Chinese medicine is mainly used to improve immune function of human body, the anti-myocardial ischemia of enhancing body resistance and coronary dilating.Radix Ginseng can make myocardial contraction strengthen in right amount, vasodilation, and blood pressure regulation, Herba Epimedii energy coronary blood flow increasing and raising hypoxia-bearing capability can be expanded external perihaemal canal again, strengthen the acra blood flow, microcirculation improvement, and the blood lipid-reducing blood sugar-decreasing effect is arranged; Radix Puerariae energy coronary artery dilating reduces myocardium keto consumption, anticoagulant.If the suitable strengthening the body resistance effect of prescription is remarkable.
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine in the distressed angor Chinese medicine of the control coronary disease of the present invention Guanxintong pharmaceutical formulation comprises:
Chinese juniper beach wormwood 15%-50%
Rhizoma Coptidis 5%-20%
Rhizoma Pinelliae 10%-40%
Fructus Aurantii Immaturus 5%-20%
Herba Artemisiae Scopariae 0-5%
The preferred compositing range of above-mentioned the chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine is:
Chinese juniper beach wormwood 30%-50%
Rhizoma Coptidis 10%-20%
Rhizoma Pinelliae 20%-30%
Fructus Aurantii Immaturus 10%-20%
Herba Artemisiae Scopariae 10%-30%
The heat clearing away of Chinese juniper beach wormwood is eliminated the phlegm, the chest stuffiness relieving promoting the circulation of QI, and lowering blood fat and dilating coronary artery, function of resisting myocardial ischemia is remarkable; Rhizoma Coptidis energy pathogenic fire purging heat clearing away and restlessness relieving, " removing the thinking stagnant blood ", the energy coronary blood flow increasing, and blood pressure lowering and relaxing smooth muscle effect are arranged; The full knot of Rhizoma Pinelliae diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, acute pain in the epigastrium, the adding of Fructus Aurantii Immaturus, Herba Artemisiae Scopariae two flavors increases synergism, and the chest stuffiness relieving reduces phlegm, the turbid descending effect has well especially.
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic in the Chinese medicine Guanxintong formulation components of the distressed angor of control coronary disease of the present invention comprises:
Rhizoma Chuanxiong 10%-50%
Rhizoma Curcumae Longae 5%-40%
Pollen Tyjphae 0-40%
Herba Asari 5%-20%
Radix Paeoniae Rubra 0-30%
Oletum Trogopterori 0-30%
The preferred compositing range of above-mentioned regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic is:
Rhizoma Chuanxiong 20%-40%
Rhizoma Curcumae Longae 15%-30%
Pollen Tyjphae 20%-30%
Herba Asari 10%-20%
Radix Paeoniae Rubra 5%-20%
Oletum Trogopterori 5%-15%
Rhizoma Chuanxiong in the above-mentioned prescription, Rhizoma Curcumae Longae are the gas medicine in the blood, and the two equal energy coronary artery dilator increases the myocardial nutrition blood flow, reduces myocardium keto consumption, suppresses platelet aggregation, helps preventing or alleviating atherosclerosis, and the energy pain relieving; It is coronary blood flow increasing that Pollen Tyjphae mainly acts on, and microcirculation improvement again can atherosclerosis; The Herba Asari blood vessel dilating, understand things pain-stopping, enhancing lipid metabolism improve the body metabolic function, share with other components, play regulating the flow of QI to dissipate blood stasis altogether, and removing obstruction in the collateral to relieve pain is alleviated the effect of disease.
The Chinese medicine Guanxintong preparation of control angina pectoris of the present invention is Guanxintong watered pill, Guanxintong powder, Guanxintong capsule, Guanxintong tablet, Guanxintong injection, Guanxintong electuary and Guanxintong mixture.
The used adjuvant of Guanxintong preparation is disintegrating agent, correctives, antiseptic, binding agent, diluent, lubricant, auxiliary shape agent.
The preparation method of the Chinese medicine Guanxintong preparation of control angina pectoris of the present invention is characterized in that comprising the steps:
A cleans former medicine, airing, need section person's section;
The b Radix Puerariae is by prescription metering, and it is standby that three extracting juice of decocting separately, extracting solution merge precipitation, filtration, vacuum concentration;
C Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavors are pressed the prescription metering and are merged three extracting juice of decocting, and extracting solution merges precipitation, filtration, vacuum, concentrated standby;
D Radix Ginseng, Herba Epimedii, Radix Puerariae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Chinese juniper beach wormwood, Rhizoma Coptidis, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, Herba Artemisiae Scopariae, Rhizoma Chuanxiong, Rhizoma Curcumae Longae, Pollen Tyjphae, Herba Asari, Radix Paeoniae Rubra, Oletum Trogopterori, merge three extracting juice of decocting by the prescription metering, extracting solution merges precipitation, filtration, vacuum, it is standby to concentrate;
E Radix Ginseng, Herba Epimedii, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Chinese juniper beach wormwood, Rhizoma Coptidis, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, Herba Artemisiae Scopariae, Pollen Tyjphae, Herba Asari, Radix Paeoniae Rubra, that 100 mesh sieves are crossed in the powder process of Oletum Trogopterori pulverize separately is standby;
F adds adjuvant, preparation shaping, test package.
Preparation method according to above-mentioned Guanxintong preparation, wherein the preparation method of Guanxintong watered pill is: water extraction concentrated solution spray general one-tenth watered pill in the powder of all the other components of the mix homogeneously that measures of the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavor Chinese medicines, 60 ± 5 ℃ of oven dry down, upper garment, polishing, packing.
The preparation method of Guanxintong powder of the present invention is: the water extraction concentrated solution of the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavor Chinese medicines is even with the powder mixes of all the other components that measure, and dries or crushing packing for 60 ± 5 ℃.
The preparation method of Guanxintong capsule is: the water extraction concentrated solution and the powder mixes of all the other components that measure of the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavor Chinese medicines are granulated, and 60 ± 5 ℃ of oven dry are crossed 80 mesh sieves, the granule capsule of packing into.
The preparation method of Guanxintong tablet is: the water extraction concentrated solution of the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavor Chinese medicines is granulated with the powder mixes of all the other components that measure, and is dry, add an amount of disintegrating agent magnesium stearate, an amount of mixing of lubricant ethanol, granulate, tabletting, mix slurry coating, packing.
The preparation method of the Chinese medicine Guanxintong injection of control angina pectoris of the present invention is: the water extract concentrated solution of each component is cooled to below 50 ℃ in will filling a prescription, adding ethanol to pure content 70%-80% stirring extracts, 2 ℃ of-2 ℃ of following cold preservations are more than 8 hours, filtered and recycled ethanol is to extractum proportion 1.20-1.26, with fresh cool distilled water solution dilution, cold preservation is more than 8 hours, NaOH with 10% transfers between the PH6.5-7.0, boil and add 80 ℃ of following decolourings half an hour of active carbon, filter, filtrate is transferred PH to 6.8-7, distilled water diluting, fine straining, check, embedding, sterilization, lamp inspection, packing.
The preparation method of Guanxintong electuary is the water extraction concentrated solution with each component in the prescription, adds ethanol and extracts half an hour to containing pure amount 60%-70% stirring, and precipitation, filtration are reclaimed ethanol and got extractum density about 1.2 under the vacuum.Extractum adds an amount of correctives such as Icing Sugar, auxiliary shape agent, dextrin or starch mixing, granulates, and is dry below 80 ℃, granulate, packing.
The Chinese medicine Guanxintong mixture preparation method of control angina pectoris of the present invention, the water extraction concentrated solution of each component in the prescription, add ethanol to pure content 60%-70%, stir and extract half an hour, precipitation, filtration are reclaimed ethanol and are got extractum, proportion about 1.2, extractum dilutes with dissolved in distilled water, stirs evenly; Boiling sterilization, filtration are 0-5 ℃ of freezing filtration more than 12 hours.Add correctives, sucrose, aseptic, filtration rear solution, antiseptic such as benzene sodium hyaluronate plus, dilution, accent PH6.5-7.0 fill.
The present invention will now be further detailed embodiment:
[embodiment one]
A kind of be applicable to the shortness of breath and fatigue people with the Guanxintong preparation of patients with coronary heart disease uncomfortable in chest by following formulation:
5 parts of Radix Ginsengs, 10 parts of Herba Epimedii, 10 parts of Radix Puerariaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ophiopogonis, 5 parts of Fructus Schisandrae Chinensis, 10 parts of Chinese juniper beach wormwoods, 2 parts of Rhizoma Coptidis, 5 parts of the Rhizoma Pinelliaes, 5 parts of Fructus Aurantii Immaturuss, 10 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts in Rhizoma Curcumae Longae, 5 parts of Pollen Tyjphae, 3 parts of Herba Asaris, 2 parts of Radix Paeoniae Rubra, 3 parts of Oletum Trogopterori.
[embodiment two]
A kind of coronary disease pain preparation that is applicable to patient with angina pectoris is by following formulation:
5 parts of Radix Ginsengs, 10 parts of Herba Epimedii, 5 parts of the Radixs Astragali, 5 parts of Radix Ophiopogonis, 10 parts of Chinese juniper beach wormwoods, 2 parts of Rhizoma Coptidis, 5 parts of the Rhizoma Pinelliaes, 2 parts of Fructus Aurantii Immaturuss, 6 parts of Herba Artemisiae Scopariaes, 15 parts of Rhizoma Chuanxiongs, 10 parts in Rhizoma Curcumae Longae, 15 parts of Pollen Tyjphae, 5 parts of Herba Asaris, 5 parts of Radix Paeoniae Rubra, 10 parts of Oletum Trogopterori.
[embodiment three]
A kind of patient's who is applicable to greasy fur uncomfortable in chest, obesity Guanxintong preparation is by following formulation:
3 parts of Radix Ginsengs, 2 parts of Herba Epimedii, 5 parts of Radix Puerariaes, 2 parts of the Radixs Astragali, 3 parts of Radix Ophiopogonis, 15 parts of Chinese juniper beach wormwoods, 5 parts of Rhizoma Coptidis, 10 parts of the Rhizoma Pinelliaes, 10 parts of Fructus Aurantii Immaturuss, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Rhizoma Chuanxiongs, 5 parts in Rhizoma Curcumae Longae, 10 parts of Pollen Tyjphae, 2 parts of Herba Asaris, 5 parts of Radix Paeoniae Rubra, 3 parts of Oletum Trogopterori.
[embodiment four]
A kind of body of the tongue stasis of blood is dark, and the Guanxintong preparation of aversion to cold and cold limbs, myocardial infarction is pressed following formulation:
15 parts of Radix Ginsengs, 25 parts of Herba Epimedii, 5 parts of the Radixs Astragali, 5 parts of Radix Ophiopogonis, 5 parts of Chinese juniper beach wormwoods, 2 parts of Rhizoma Coptidis, 4 parts of the Rhizoma Pinelliaes, 4 parts of Fructus Aurantii Immaturuss, 5 parts of Herba Artemisiae Scopariaes, 10 parts of Rhizoma Chuanxiongs, 5 parts in Rhizoma Curcumae Longae, 5 parts of Pollen Tyjphae, 5 parts of Herba Asaris, 2 parts of Radix Paeoniae Rubra, 3 parts of Oletum Trogopterori.
[embodiment five]
A kind of Guanxintong preparation for the treatment of hyperlipidemia is by following formulation:
5 parts of Radix Ginsengs, 10 parts of Herba Epimedii, 20 parts of Radix Puerariaes, 5 parts of the Radixs Astragali, 3 parts of Radix Ophiopogonis, 2 parts of Fructus Schisandrae Chinensis, 15 parts of Chinese juniper beach wormwoods, 2 parts of Rhizoma Coptidis, 4 parts of the Rhizoma Pinelliaes, 3 parts of Fructus Aurantii Immaturuss, 10 parts of Herba Artemisiae Scopariaes, 2.5 parts of Rhizoma Chuanxiongs, 5 parts in Rhizoma Curcumae Longae, 7.5 parts of Pollen Tyjphae, 3 parts of Herba Asaris, 2 parts of Radix Paeoniae Rubra, 1 part of Oletum Trogopterori.
[embodiment six]
A kind of control coronary disease pain is pressed following formulation with hypertensive Guanxintong preparation:
3.5 parts of Radix Ginsengs, 10 parts of Herba Epimedii, 10 parts of Radix Puerariaes, 9.5 parts of the Radixs Astragali, 2 parts of Radix Ophiopogonis, 10 parts of Chinese juniper beach wormwoods, 2 parts of Rhizoma Coptidis, 3 parts of the Rhizoma Pinelliaes, 2 parts of Fructus Aurantii Immaturuss, 13 parts of Herba Artemisiae Scopariaes, 10 parts of Rhizoma Chuanxiongs, 10 parts in Rhizoma Curcumae Longae, 5 parts of Pollen Tyjphae, 3 parts of Herba Asaris, 5 parts of Radix Paeoniae Rubra, 2 parts of Oletum Trogopterori.
[embodiment seven]
The Guanxintong preparation of the coronary heart disease that a kind of treatment is caused by diabetes is by following formulation:
15 parts of Radix Ginsengs, 10 parts of Herba Epimedii, 10 parts of Radix Puerariaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ophiopogonis, 5 parts of Chinese juniper beach wormwoods, 4 parts of Rhizoma Coptidis, 2 parts of the Rhizoma Pinelliaes, 5 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts in Rhizoma Curcumae Longae, 10 parts of Pollen Tyjphae, 3 parts of Herba Asaris, 5 parts of Radix Paeoniae Rubra, 2 parts of Oletum Trogopterori.
By the prescription among the above embodiment 1-7 in addition the adjuvant thing can make Guanxintong watered pill, Guanxintong powder, Guanxintong capsule, Guanxintong tablet, Guanxintong injection, Guanxintong electuary and Guanxintong mixture.
Observe for anti-experimental character myocardial ischemia and acute toxicity testing that Guanxintong preparation of the present invention carries out, the result is as follows:
1, mice normal pressure hypoxia endurance test:
With body weight 20.64 ± 0.67 gram mices, be divided into 5 groups by body weight, Guanxintong 5g/kg2 group, FUFANG DANSHEN PIAN 5.4g/kg1 organize, contrast 2 groups with capacity water.The difference gastric infusion, once a day, successive administration 3 days, after the last administration 90 minutes, wherein each one group of Guanxintong and water contrast gave isoproterenol 1.5mg/kg body weight in preceding 5 minutes in experiment, then mice was put into the 150ml wide mouthed bottle, survey its death time, result such as table 1.
The influence of table 1 pair mice normal pressure hypoxia endurance time
The group Mus is counted the death time (branch)
Water matched group 11 13.48 ± 1.11
Water+different third kidney 14 12.38 ± 1.81
Guanxintong 11 18.91 ± 6.34
Guanxintong+different third kidney 13 13.68 ± 2.01
FUFANG DANSHEN PIAN 11 14.55 ± 2.41
2, acute toxicity testing:
The 18-20g mice, 40, wherein press maximum tolerated dose administration every day 4 times for 20, dosage is 100g/rgd, 20 is the water matched group in addition, successive administration three days was observed 7 days two groups of mice feeds of result activity, stool, all no abnormal change of fur continuously behind the medicine, and after 7 days, two groups of mices, body weight are respectively 21.84 ± 1.37 and 21.63 ± 1.84g, do not find differences between group.
Guanxintong preparation of the present invention is used for clinical experiment, and observed result is as follows:
Select study subject 182 examples, 146 examples of wherein being in hospital, outpatient service 36 examples; Male's 125 examples, women's 57 examples.121 examples are organized in treatment, matched group 61 examples.40 years old of age minimum, maximum 82 years old.Age distribution situation 40-49 year person's 48 examples, 50-59 year person's 63 examples, 60-69 year person's 52 examples, person's 19 examples more than 70 years old.
Wherein just send out fatigue angina pectoris 15 examples, stablize fatigue angina pectoris 130 examples, worsen fatigue angina pectoris 25 examples, non-fatigue angina pectoris 6 examples, old heart infarction 16 examples, acute myocardial infarction 3 examples, complicated hypertension 18 examples, diabetes 4 examples, arrhythmia 7 examples.
Angina pectoris symptom curative effect and FUFANG DANSHEN PIAN contrast see Table 2.
Table 2
Group example digital display is imitated (%) effective (%) invalid (%) and is increased the weight of (%) total effective rate (%)
Guanxintong 118 103 (87.3) 13 (11) 2 (1.7) 0 (0) 116 (98.3)
FUFANG DANSHEN PIAN 59 8 (13.6) 24 (40.6) 25 (42.4) 2 (3.4) 32 (54.2)
ECG curative effect sees Table 3
Table 3
Group example digital display is imitated (%) effective (%) invalid (%) and is increased the weight of (%) total effective rate (%)
Guanxintong 109 49 (45.0) 28 (25.7) 32 (19.3) 0 (0) 77 (70.7)
FUFANG DANSHEN PIAN 49 2 (4.1) 14 (28.6) 30 (61.2) 3 (6.1) 16 (32.7)
Below in conjunction with model case, the curative effect of the Chinese medicine Guanxintong preparation of control angina pectoris of the present invention is done further narration.
1, woods * * man, 63 years old, the workman was admitted to hospital that Shu Yinfa is not uncomfortable in chest for cause fatigue in two days and feelings will, the pareordia discomfort is dizzy weak, day outbreak 2-3 time, the back electrocardio of being admitted to hospital illustrates, acute myocardial ischemia, S-T section II III aVF moves down 0.05-0.22mV V
5Move down 0.3mV, T ripple II III aVF V
5Example is put or two-phase, is diagnosed as angina pectoris.Give Guanxintong 6g, day clothes 3 times, symptom is clearly better electrocardiogram after 3 days: S-T section II III aVFV
5Move down 0.05-0.15mV, transference cure after 6 days, behind the first quarter moon that continues to take medicine, S-T section V
5Return to 0.05mV by moving down 0.15, T ripple V
3-5Voltage uprises.
2, the king * * man, 51 years old, the cadre.Because of nervous, uncomfortable in chest, the paroxysmal of breathing hard is shown effect a week, the clothes FUFANG DANSHEN PIAN, and drug effects such as storax pill for treating coronary heart disease do not show, and day outbreak 3 times, persistent period reach 1 hour most, are admitted to hospital and look into the electrocardio diagram: S-T avFV
5Move down 0.5mm, blood fat: cholesterol 5.49mmol, triglyceride 1.73mmol, beta lipoprotein 18.13mmol, be diagnosed as coronary disease pain fatigue angina pectoris, give Guanxintong 6g, day 3 times, symptom obviously alleviates after 3 days, 1 all transference cures, 3 weeks back check electrocardiogram is roughly normal.Blood fat: cholesterol 5.53mmol, triglyceride 1.15mmol, beta lipoprotein 11.9mmol.
3, the king * * man, 63 years old, the peasant.Feeling of oppression and pain in the chest shows effect year surplus in the of 10 repeatedly, increases the weight of for 1 week, and chest pain nervous outbreak uncomfortable in chest is frequent, drug effect does not show after taking Radix Salviae Miltiorrhizae Tabellae, is admitted to hospital and looks into electrocardio diagram: S-T, and T changes, be diagnosed as coronary heart disease, fatigue angina pectoris (stable type) is given Guanxintong 9 grams, day 3 times, took medicine 3 days, symptom subtracts greatly, transference cure after 7 days, and the check electrocardiogram is normal behind the first quarter moon.
The present invention has following advantage compared to existing technology:
1, can prevent, can control, have no side effect, but long-term taking;
2, have concurrently strengthen the body resistance to consolidate the constitution, the function of resolving phlegm lowering turbidity, regulating qi to dissipate blood stasis pain relieving;
3, the long-term taking for the treatment of both principal and secondary aspect of disease can improve immune function of human body, strengthens Abwehrkraft des Koepers;
4, determined curative effect, symptom is eliminated rapidly, and efficient up to 98.3%;
5, hemangiectasis is regulated blood pressure, and blood lipid-reducing blood sugar-decreasing suppresses platelet aggregation, prevents or alleviates atherosclerotic, and curative effect is comprehensively to coronary disease and angina pectoris cure rate height.
Claims (19)
1, a kind of Chinese medicine Guanxintong preparation of preventing and treating angina pectoris is characterized in that being made of following component and pharmaceutical adjunct,
Strengthening the body resistance Chinese medicine 15%-50%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 20%-50%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 15%-65%
2,, it is characterized in that the preferred ingredients scope is according to the Guanxintong preparation of claim 1:
Strengthening the body resistance Chinese medicine 20%-40%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 25%-40%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 20%-45%
3,, it is characterized in that optimum compositional range is according to the Guanxintong preparation of claim 1:
Strengthening the body resistance Chinese medicine 30%-40%
The chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine 30%-35%
Regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic 25%-35%
4,, it is characterized in that described strengthening the body resistance Chinese medicine comprises according to the Guanxintong preparation of claim 1:
Radix Ginseng 10%-50%
Herba Epimedii 10%-60%
Radix Puerariae 0-50%
Radix Astragali 10%-70%
Radix Ophiopogonis 5%-55%
Fructus Schisandrae Chinensis 0-30%
5,, it is characterized in that the preferred compositing range of described strengthening the body resistance Chinese medicine is according to the Guanxintong preparation of claim 1:
Radix Ginseng 20%-40%
Herba Epimedii 20%-40%
Radix Puerariae 10-30%
Radix Astragali 10%-30%
Radix Ophiopogonis 10%-30%
Fructus Schisandrae Chinensis 10%-25%
6,, it is characterized in that described the chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine comprises according to the Guanxintong preparation of claim 1:
Chinese juniper beach wormwood 15%-50%
Rhizoma Coptidis 5%-20%
Rhizoma Pinelliae 10%-40%
Fructus Aurantii Immaturus 5%-20%
Herba Artemisiae Scopariae 0-50%
7,, it is characterized in that the described preferred compositing range of the chest stuffiness relieving resolving phlegm lowering turbidity Chinese medicine is according to the Guanxintong preparation of claim 1:
Chinese juniper beach wormwood 30%-50%
Rhizoma Coptidis 10%-20%
Rhizoma Pinelliae 20%-30%
Fructus Aurantii Immaturus 10%-20%
Herba Artemisiae Scopariae 10%-30%
8,, it is characterized in that described regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic comprises according to the Guanxintong preparation of claim 1:
Rhizoma Chuanxiong 10%-50%
Rhizoma Curcumae Longae 5%-40%
Pollen Tyjphae 0-40%
Herba Asari 5%-20%
Radix Paeoniae Rubra 0-30%
Oletum Trogopterori 0-30%
9,, it is characterized in that the preferred compositing range of described regulating the flow of QI to dissipate blood stasis Traditional Chinese medicine used as analgesic is according to the Guanxintong preparation of claim 1:
Rhizoma Chuanxiong 20%-40%
Rhizoma Curcumae Longae 15%-30%
Pollen Tyjphae 20%-30%
Herba Asari 10%-20%
Radix Paeoniae Rubra 5%-20%
Oletum Trogopterori 5%-15%
10,, it is characterized in that it being Guanxintong watered pill, Guanxintong powder, Guanxintong capsule, Guanxintong tablet, Guanxintong injection, Guanxintong electuary and Guanxintong mixture according to the described Guanxintong preparation of claim 1.
11,, it is characterized in that described pharmaceutical adjunct is disintegrating agent, correctives, antiseptic, binding agent, diluent, lubricant, auxiliary shape agent according to the described Guanxintong preparation of claim 1.
12, a kind of preparation method of preventing and treating the Chinese medicine Guanxintong preparation of angina pectoris is characterized in that comprising the steps:
A with former medicine clean, airing, section;
The b Radix Puerariae is by prescription metering, and it is standby that three extracting juice of decocting separately, extracting solution merge precipitation, filtration, vacuum concentration;
C Rhizoma Chuanxiong, Rhizoma Curcumae Longae two are distinguished the flavor of and merge three extracting juice of decocting by the prescription weighing, and extracting solution merges precipitation, filtration, vacuum, concentrated standby;
D Radix Ginseng, Herba Epimedii, Radix Puerariae, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Chinese juniper beach wormwood, Rhizoma Coptidis, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, Herba Artemisiae Scopariae, Rhizoma Chuanxiong, Rhizoma Curcumae Longae, Pollen Tyjphae, Herba Asari, Radix Paeoniae Rubra, Oletum Trogopterori, merge three extracting juice of decocting by the prescription metering, extracting solution merges precipitation, filtration, vacuum, it is standby to concentrate;
E Radix Ginseng, Herba Epimedii, the Radix Astragali, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Chinese juniper beach wormwood, Rhizoma Coptidis, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, Herba Artemisiae Scopariae, Pollen Tyjphae, Herba Asari, Radix Paeoniae Rubra, that 100 mesh sieves are crossed in the powder process of Oletum Trogopterori pulverize separately is standby;
F adds adjuvant, preparation shaping, test package.
13, according to the method for claim 12, the preparation method that it is characterized in that the Guanxintong watered pill is, water extraction concentrated solution spray general one-tenth watered pill in the powder of all the other components of mix homogeneously with Radix Puerariae, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong in the prescription, Rhizoma Curcumae Longae two flavor Chinese medicines, 60 ± 5 ℃ of oven dry down, upper garment, polishing, packing.
14, according to the method for claim 12, the preparation method that it is characterized in that Guanxintong powder is that the powder mixes of the water extraction concentrated solution of Radix Puerariae, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong in the prescription, Rhizoma Curcumae Longae two flavor Chinese medicines and all the other components is even, dries or crushing packing for 60 ± 5 ℃.
15, according to the method for claim 12, the preparation method that it is characterized in that the Guanxintong capsule is: the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, the water extraction concentrated solution of Rhizoma Curcumae Longae two flavor Chinese medicines and the powder mixes of all the other components are granulated, 60 ± 5 ℃ of oven dry, cross 80 mesh sieves, the granule capsule of packing into.
16, according to the method for claim 12, the preparation method that it is characterized in that the Guanxintong tablet is: the water extraction concentrated solution of the Radix Puerariae in will filling a prescription, Rhizoma Chuanxiong, Rhizoma Curcumae Longae three flavors or Rhizoma Chuanxiong, Rhizoma Curcumae Longae two flavor Chinese medicines is granulated with the powder mixes of all the other components, and is dry, add an amount of disintegrating agent, binding agent, granulate, tabletting, mix and starch coating, packing.
17, according to the method for claim 12, the preparation method that it is characterized in that the Guanxintong injection is: the water extract solution of each component cooling in will filling a prescription, ethanol extraction, cold preservation, filtration, concentrated, with fresh cool distilled water solution dilution, cold preservation, filtration, accent pH value, boiling decoloring, filtration, filtrate are transferred PH to 6.8-7, distilled water diluting, fine straining, check, embedding, sterilization, lamp inspection, packing.
18,, it is characterized in that the preparation method of Guanxintong electuary is according to the method for claim 12: the water extraction concentrated solution ethanol extraction of each component in will filling a prescription, filter, reclaim ethanol and get extractum, extractum adds an amount of correctives, auxiliary shape agent mixing, granulate, dry below 80 ℃, granulate, packing.
19, according to the method for claim 12, the preparation method that it is characterized in that the Guanxintong mixture is: the water extraction concentrated solution ethanol extraction of each component in the prescription, filter, reclaim ethanol and get extractum, the extractum distilled water diluting, sterilization, filtration, freezing, filtration adds correctives, antiseptic, dilution, accent pH value, embedding, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93115163A CN1045892C (en) | 1993-10-18 | 1993-10-18 | Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93115163A CN1045892C (en) | 1993-10-18 | 1993-10-18 | Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1101841A true CN1101841A (en) | 1995-04-26 |
| CN1045892C CN1045892C (en) | 1999-10-27 |
Family
ID=4990844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93115163A Expired - Fee Related CN1045892C (en) | 1993-10-18 | 1993-10-18 | Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1045892C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411846B (en) * | 2008-11-26 | 2011-02-16 | 四川省中医药科学院中医研究所 | Chinese medicine for tonifying kidney, resolving stasis, softening pulse and strengthening brain |
| CN102846937A (en) * | 2012-08-31 | 2013-01-02 | 霍山县中医院 | Chinese herbal medicine for treating dilated cardiomyopathy |
| CN103463409A (en) * | 2013-08-20 | 2013-12-25 | 曹洪欣 | Traditional Chinese medicine formula for treating heart qi deficiency |
| CN104435650A (en) * | 2014-11-19 | 2015-03-25 | 张锐 | Traditional Chinese medicine for treating stenocardia and preparation method of traditional Chinese medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074613A (en) * | 1993-01-18 | 1993-07-28 | 邱天道 | Xintai paste for heart safety |
-
1993
- 1993-10-18 CN CN93115163A patent/CN1045892C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411846B (en) * | 2008-11-26 | 2011-02-16 | 四川省中医药科学院中医研究所 | Chinese medicine for tonifying kidney, resolving stasis, softening pulse and strengthening brain |
| CN102846937A (en) * | 2012-08-31 | 2013-01-02 | 霍山县中医院 | Chinese herbal medicine for treating dilated cardiomyopathy |
| CN102846937B (en) * | 2012-08-31 | 2013-11-06 | 霍山县中医院 | Chinese herbal medicine for treating dilated cardiomyopathy |
| CN103463409A (en) * | 2013-08-20 | 2013-12-25 | 曹洪欣 | Traditional Chinese medicine formula for treating heart qi deficiency |
| CN104435650A (en) * | 2014-11-19 | 2015-03-25 | 张锐 | Traditional Chinese medicine for treating stenocardia and preparation method of traditional Chinese medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1045892C (en) | 1999-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1240416C (en) | Medicine for curing hypertension and its preparation method | |
| CN1621080A (en) | Medicine for abstaining from drug addiction and its preparation | |
| CN1915399A (en) | Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method | |
| CN1045892C (en) | Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof | |
| CN1279944C (en) | Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation | |
| CN102178798A (en) | Preparation for reducing blood fat, preventing and treating cardiovascular and cerebrovascular diseases | |
| CN101618131A (en) | Chinese medicinal compound preparation for treating coronary heart disease and angina | |
| CN1111054C (en) | Medicine for treating apoplexy and its preparing process | |
| CN1927331A (en) | Chinese medicine preparation for curing chronic heart failure | |
| CN1733242A (en) | A kind of medicine for treating qi deficiency and blood stasis type chest obstruction (coronary heart disease) and its preparation process | |
| CN1232283C (en) | Chinese drugs for treatment of coronary heart disease and angina pectoris | |
| CN1245197C (en) | Chinese medicine preparation for treating coronary heart disease and viral myocarditis | |
| CN1276764C (en) | Application of traditional Chinese medicine composition in preparation of medicine for treating iron-deficiency anemia | |
| CN1129447C (en) | Anshen pill-treating cardio-cerebral angiopathy | |
| CN1253188C (en) | Medicine for treating hypertension and its preparing process | |
| CN1990033A (en) | Drug for treating hypertension, dense blood and arteriosclerosis | |
| CN1186054C (en) | Medicine for treating osteoporosis and preparation method thereof | |
| CN102755444A (en) | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof | |
| CN113144080B (en) | Traditional Chinese medicine for treating coronary atherosclerotic plaques | |
| CN1141113C (en) | Chinese patent medicine for curing peptic ulcer | |
| CN1256963C (en) | Antifatigue medicine and its preparation method | |
| CN100344301C (en) | Orally medicine for treating vitiligo and production method thereof | |
| CN1682892A (en) | A kind of Tengdan capsule for treating hypertension | |
| CN1562163A (en) | Anti-cancer Chinese medicinal composition and its preparing method | |
| CN1283308C (en) | Chinese medicime liposome for treating viral hepatitis B and preventing liver cell from fibriform and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |