CN110100814A - A kind of whole day urine preservative, preparation method and applications - Google Patents

Abstract

The present patent application discloses a kind of whole day urine preservative, preparation method and applications.Whole day urine preservative includes P-hydroxybenzoic acid, Macrogol 6000 (or lactose and microcrystalline cellulose), carboxyrnethyl starch sodium, hard magnesium, silica.The preparation method step of whole day urine preservative includes preparing the raw material of corresponding proportion and being mixed and made into powder or tablet at normal temperature；Powder formulation or tablet preparation can be applicable to urine detection.Preservative of the invention, the bacterial reproduction of urine to be detected can greatly be inhibited, the content of project tie substance to be detected is kept simultaneously, prevent urine specimen to be detected from occurring rotten and influencing detection error, with good anti-corrosion effect, it applies in urine detection, combination urine collecting device that can be easier than traditional preservative uses.

Description

A kind of all-day urine preservative, preparation method and application thereof

technical field

This application relates to the technical field of chemical preparations for medical testing, specifically urine preservatives, preparation methods and applications of urine preservatives.

Background technique

Routine urine test is one of the "three routine" inspection items, and its test results, such as red blood cell positive rate, white blood cell positive rate, and urine protein level, can reflect some early symptoms. Routine examination of urine is a detection item with great clinical application value in renal function test. Because urine is easily contaminated by bacteria, the accuracy of test results is affected, which has a great impact on clinical diagnosis and treatment. Therefore, the preservation of urine is of great significance to ensure the accuracy of urine test results. At present, the commonly used urine antiseptic measures in clinical practice are xylene and toluene, which achieve antiseptic effect by isolating urine from contact with air. But its obvious disadvantage is that it is easy to be mixed into urine and sampled together during the inspection. At the same time, xylene and toluene are carcinogens and the dosage is difficult to control. They are harmful to the human body and are inconvenient to carry and store.

Contents of the invention

In order to solve one or more technical problems in the background technology, the present invention proposes an all-day urine preservative, a preparation method of a urine preservative and its application.

The invention provides an all-day urine preservative, the components and corresponding weight ratios are: p-hydroxybenzoic acid accounts for 6-34%, lactose accounts for 47-59.9%, and microcrystalline cellulose accounts for 16-29.9% %, sodium starch glycolate accounts for 1.02-3%, magnesium stearate accounts for 0.37-2%, and silicon dioxide accounts for 0.37-2%.

Or: p-hydroxybenzoic acid accounts for 6-34%, polyethylene glycol 6000 accounts for 65-88%, carboxymethyl starch sodium accounts for 1.02-3%, magnesium stearate accounts for 0.37-2%, dioxide Silicon accounts for 0.37-2%.

Compared with the prior art, the beneficial effect is that: compared with traditional preservatives, this all-day urine preservative can inhibit the reproduction of bacteria in the urine sample without destroying the original urine sample, and maintain the urine sample. The stability of the substances to be tested can avoid the deterioration of the sample after 24 hours and the original sample, which will affect the data error of each test item, and greatly improve the antiseptic performance of the urine preservative.

The present invention also provides a method for preparing an all-day urine preservative, the preparation steps of which are as follows:

S1. Prepare corresponding raw materials according to the following weight ratios: p-hydroxybenzoic acid accounts for 6-34%, lactose accounts for 47-59.9%, microcrystalline cellulose accounts for 16-29.9%, and carboxymethyl starch sodium accounts for 1.02-3%. , magnesium stearate accounted for 0.37-2%, silicon dioxide accounted for 0.37-2%;

S2. At room temperature, uniformly mix the components in S1 into a powder preparation, or press to form a tablet preparation.

or as:

S1. Prepare corresponding raw materials according to the following weight ratios: p-hydroxybenzoic acid accounts for 6-34%, polyethylene glycol 6000 accounts for 65-88%, carboxymethyl starch sodium accounts for 1.02-3%, and magnesium stearate accounts for 1.02-3%. 0.37-2%, silicon dioxide accounted for 0.37-2%;

S2. At room temperature, uniformly mix the components in S1 into a powder preparation, or press to form a tablet preparation.

Compared with the prior art, the beneficial effect is that the preparation method has simple and convenient steps, does not require severe reaction conditions, is low in cost, can be used in large-scale production, and can flexibly select the form of the preparation.

The invention also provides the application of the all-day urine preservative in urine detection or storage instruments.

The present invention further provides a urine preservative for all-day use, which is made into a powder preparation or a tablet preparation.

Compared with the prior art, the beneficial effect is that: as a preservative used in urine testing, the powder preparation or tablet preparation can be adapted to urine testing devices of different specifications and scenarios, and the urine can be treated immediately when the urine is collected. Add preservatives to the liquid samples, or place preservatives in the urine collector in advance to prevent the urine samples from deteriorating or being contaminated before adding preservatives.

Detailed ways

In order to make the principle of the technical solution of the present invention clear and complete, the content of some implementations is listed below to further elaborate the technical solution of the present application.

The specific implementation of the urine preservative for all day use includes 6 groups of examples, and the corresponding ingredients and weight percentages are shown in Table 1 below, and the % behind the numbers is omitted in the table.

Table 1

Correspondingly, the preparation method of embodiment 1 to 6 is realized by the following steps:

Step 1, prepare corresponding raw materials according to table components and weight ratio;

Step 2. At room temperature, uniformly mix and stir the above components to form a powder preparation, or press to form a tablet preparation.

The powder preparation or tablet preparation obtained by the aforementioned preparation method is used in urine detection.

For the foregoing embodiments 1 to 6, a group of no preservatives and a group of imported preservatives were used as control groups in the urine samples to be tested, and several routine urine testing items were used as test results. Illustrate its anticorrosion effect, concrete effect is as shown in following table 2 to table 4:

Anticorrosion effect of the control group in table 2

The preservative effect of table 3 embodiment 1 to 3

The anticorrosion effect of table 4 embodiment 4 to 6

From the data in Table 2 to Table 4, it can be seen that the data of the non-preserved group fluctuated, especially the data of nitrite and bacteria count increased significantly, and a large number of bacteria reproduced. However, after the preservative of the present invention was added in Examples 1 to 6, each test data compared with the urine sample at the beginning after 24 hours or even 48 hours, and the various component indexes including bacterial counts all changed less, The effect was comparable to that of the imported preservative group (urine morphology was not included in this evaluation index). It can be seen that the all-day urine preservatives of Examples 1 to 6 can maintain stable properties within 24 hours, play a long-term bactericidal effect, and will not affect the detection of urine chemical items at the same time, achieving good antiseptic effect.

Imported preservatives are expensive, and the all-day urine preservative of the present invention can greatly reduce the cost while achieving a very good antiseptic effect.

In addition, the all-day urine preservative of the present invention is widely used, and can also be used in airports, schools, hospitals and other public toilets, as well as the antiseptic function of urine in animal husbandry, pigs, cattle and sheep.

The above embodiments are only a part of the technical solution of the present application, but not the whole content of the present invention. It should be clear to those skilled in the art that any equivalent replacement or simple addition or subtraction of technical means to the above implementations does not produce substantive features, and still falls within the scope defined by the technical solution of the present application. The protection scope of the claims of this application is defined by the claims.

Claims (6)

1. An all-day urine preservative, characterized in that its components and weight ratio are: p-hydroxybenzoic acid accounts for 6-34%, lactose accounts for 47-59.9%, and microcrystalline cellulose accounts for 16% -29.9%, sodium starch glycolate accounts for 1.02-3%, magnesium stearate accounts for 0.37-2%, and silicon dioxide accounts for 0.37-2%. 2. A urine preservative for all day use, characterized in that its components and weight ratio are: p-hydroxybenzoic acid accounts for 6-34%, polyethylene glycol 6000 accounts for 65-88%, and carboxymethyl starch Sodium accounts for 1.02-3%, magnesium stearate accounts for 0.37-2%, and silicon dioxide accounts for 0.37-2%. 3. according to the preparation method of the described all-day urine preservative of claim 1, it is characterized in that, the preparation steps are as follows: S1. Prepare corresponding raw materials according to the following weight ratios: p-hydroxybenzoic acid accounts for 6-34%, lactose accounts for 47-59.9%, microcrystalline cellulose accounts for 16-29.9%, and carboxymethyl starch sodium accounts for 1.02-3%. , magnesium stearate accounted for 0.37-2%, silicon dioxide accounted for 0.37-2%; S2. At room temperature, uniformly mix the components in S1 into a powder preparation, or press to form a tablet preparation. 4. according to the preparation method of the described all-day urine preservative of claim 2, it is characterized in that, the preparation steps are as follows: S1. Prepare corresponding raw materials according to the following weight ratios: p-hydroxybenzoic acid accounts for 6-34%, polyethylene glycol 6000 accounts for 65-88%, carboxymethyl starch sodium accounts for 1.02-3%, and magnesium stearate accounts for 1.02-3%. 0.37-2%, silicon dioxide accounted for 0.37-2%; S2. At room temperature, uniformly mix the components in S1 into a powder preparation, or press to form a tablet preparation. 5. An application of the all-day urine preservative according to claim 1 or 2 in urine detection or storage instruments. 6. An all-day urine antiseptic prepared by the preparation method according to claim 3 or 4, characterized in that, the antiseptic is a powder preparation or a tablet preparation.