CN119837491A - Noninvasive intraocular pressure measurement system - Google Patents
Noninvasive intraocular pressure measurement system Download PDFInfo
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- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
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Abstract
本申请提供一种无创眼压测量系统，包括眼压测量设备、谐振电路、环境温度采集设备和眼压测量校正单元，其中眼压测量校正单元通过从眼压测量设备中获取眼内湿度数据和眼压测量数据，从环境温度采集设备中获取环境温度；通过眼内湿度数据确定多个电容漂移量，进而将所有的电容漂移量转化为每次湿度变化时的频率漂移代价；基于线性回归特征确定温‑压回归系数，进而通过温‑压回归系数进行代价拟合，得到每个眼压测量值的温度补偿代价；依据各个频率漂移代价和各个温度补偿代价调整谐振频率，基于调整后的谐振频率对眼压测量结果进行校正。采用本申请的方案，在佩戴眼压测量设备过程中，可避免环境因素的变化对测量精度的影响，对眼压进行稳定监测。
The present application provides a non-invasive intraocular pressure measurement system, including an intraocular pressure measurement device, a resonant circuit, an ambient temperature acquisition device, and an intraocular pressure measurement correction unit, wherein the intraocular pressure measurement correction unit obtains the ambient temperature from the ambient temperature acquisition device by obtaining intraocular humidity data and intraocular pressure measurement data from the intraocular pressure measurement device; determines multiple capacitance drifts through the intraocular humidity data, and then converts all capacitance drifts into frequency drift costs at each humidity change; determines the temperature-pressure regression coefficient based on the linear regression characteristics, and then performs cost fitting through the temperature-pressure regression coefficient to obtain the temperature compensation cost of each intraocular pressure measurement value; adjusts the resonant frequency according to each frequency drift cost and each temperature compensation cost, and corrects the intraocular pressure measurement result based on the adjusted resonant frequency. By adopting the scheme of the present application, the influence of changes in environmental factors on the measurement accuracy can be avoided during the wearing of the intraocular pressure measurement device, and the intraocular pressure can be stably monitored.
Description
Technical Field
The application relates to the technical field of intraocular pressure measurement, in particular to a noninvasive intraocular pressure measurement system.
Background
Tonometric measurement is a key technology in the field of ophthalmology, and is used for evaluating intraocular pressure (intraocular pressure), which plays a vital role in diagnosing and monitoring ophthalmic diseases such as glaucoma, intraocular pressure is a pressure difference between intraocular fluid (aqueous humor) and eyeball wall, stability of intraocular pressure is crucial for maintaining normal eyeball shape and function, abnormal intraocular pressure level can cause optic nerve damage, further cause vision damage and even blindness, and continuous innovation in the field of tonometric measurement provides powerful support for early diagnosis and prevention of ophthalmic diseases, and simultaneously promotes intelligent development of ophthalmic medical equipment.
The non-invasive intraocular pressure measurement is an advanced method capable of measuring intraocular pressure (IOP) without directly contacting cornea or eyeball surface, along with the increase of people's attention to eye health and the discomfort and infection risk brought by the traditional contact type measurement method, the non-invasive intraocular pressure measurement technology gradually becomes an important development direction of the ophthalmic field, the non-invasive intraocular pressure measurement not only provides comfortable experience for patients, but also makes remarkable progress in the aspects of precision, portability and intellectualization of intraocular pressure monitoring, in the prior art, after the change of resonance frequency of a circuit caused by the small change of the eye shape sensed by a sensor attached to an eyelid or worn around the eye is usually carried out, the change data is analyzed to realize the non-invasive intraocular pressure measurement, compared with other non-invasive intraocular pressure measurement methods, the non-invasive intraocular pressure measurement method has the advantage of sustainable monitoring, however, in the process of continuously monitoring intraocular pressure, the intraocular pressure measurement is caused by intraocular pressure value errors caused by intraocular pressure factors of wearing objects, for example, when the environmental temperature fluctuates, the internal room water and vitreous pressure under different temperatures are changed, such as the physical properties (such as the density) and the intraocular pressure of the intraocular pressure under different temperatures are changed, thus the measurement accuracy is stable, and the problem of the measurement is avoided in the process of measuring the measurement is realized.
Disclosure of Invention
The application provides a noninvasive intraocular pressure measuring system, which can avoid the influence of the change of environmental factors on measuring precision in the process of wearing intraocular pressure measuring equipment and realize stable monitoring of eye pressure.
In order to solve the technical problems, the application provides a non-invasive intraocular pressure measuring system, which comprises an intraocular pressure measuring device and a resonance circuit connected with the intraocular pressure measuring device, wherein the resonance circuit is used for generating a resonance frequency corresponding to intraocular pressure, in addition, the noninvasive intraocular pressure measurement system further comprises an ambient temperature acquisition device and an intraocular pressure measurement correction unit, wherein the ambient temperature acquisition device is used for acquiring ambient temperature when the target object wears the intraocular pressure measurement device, and the intraocular pressure measurement device is also used for acquiring intraocular humidity data and intraocular pressure measurement data when the target object wears the intraocular pressure measurement device;
the tonometric measurement correction unit specifically comprises an acquisition module, a conversion module, a fitting module and a correction module;
The acquisition module is used for acquiring intraocular humidity data and intraocular pressure measurement data from the intraocular pressure measurement equipment and acquiring the ambient temperature from the ambient temperature acquisition equipment;
The conversion module is used for determining a plurality of capacitance drift amounts of the resonant circuit after being affected by humidity through the intraocular humidity data and the dielectric characteristics of equipment materials, and further converting all the capacitance drift amounts into frequency drift cost of resonant frequency in the resonant circuit when the humidity changes each time;
the fitting module is used for determining a temperature-pressure regression coefficient of the intraocular pressure of the target object based on the linear regression characteristic between the intraocular pressure measurement data and the environmental temperature, and further performing cost fitting on each intraocular pressure measurement value in the intraocular pressure measurement data through the temperature-pressure regression coefficient to obtain a temperature compensation cost of each intraocular pressure measurement value;
The correction module is used for adjusting the resonance frequency of the resonance circuit according to each frequency drift cost and each temperature compensation cost, and correcting the intraocular pressure measurement result of the target object based on the adjusted resonance frequency.
It can be appreciated that the conversion module may send the frequency drift cost of the resonant frequency in the resonant circuit at each humidity change to the correction module;
The fitting module can send the temperature compensation cost of each intraocular pressure measurement value to the correction module;
the correction module can adjust the resonance frequency of the resonance circuit according to each frequency drift cost and each temperature compensation cost, so that the intraocular pressure measurement result is corrected according to the adjusted resonance frequency.
The noninvasive intraocular pressure measuring system adjusts the resonant frequency of the resonant circuit through the frequency drift cost and the temperature compensation cost, can avoid the influence of the change of environmental factors on the measuring precision in the process of wearing the intraocular pressure measuring equipment, and realizes stable monitoring of the eye pressure.
In one possible implementation, the conversion module may include a feature determination sub-module and a drift cost determination sub-module, the feature determination sub-module configured to determine a dielectric feature of the device material from the intraocular humidity data;
the drift cost determination submodule is used for converting dielectric characteristics of equipment materials into frequency drift cost of resonant frequency in the resonant circuit at each humidity change.
In another possible implementation manner, the fitting module may include a modeling submodule and a cost fitting submodule, where the modeling submodule is configured to determine a temperature-pressure regression coefficient of the intraocular pressure of the target object based on a linear regression feature between the intraocular pressure measurement data and the ambient temperature;
and the cost fitting sub-module is used for performing cost fitting on all the intraocular pressure measured values in the intraocular pressure measured data through the temperature-pressure regression coefficient to obtain the temperature compensation cost of each intraocular pressure measured value.
Further, the correction module may include an adjustment sub-module and an intraocular pressure correction sub-module;
The adjusting submodule is used for adjusting the resonant frequency of the resonant circuit through the frequency drift cost and the temperature compensation cost;
the intraocular pressure correction submodule is used for correcting the intraocular pressure detection value through the adjusted resonant frequency and further outputting the corrected intraocular pressure value.
In some embodiments, the tonometric measurement apparatus comprises a flexible contact lens within which the humidity sensor, the resonant circuit, and the ambient temperature acquisition apparatus are disposed.
In an example, the material of the flexible contact lens is gel silica, however, the flexible contact lens can be made of other materials, which is not limited herein.
In some embodiments, the resonant circuit includes a pressure sensor and an LC tank.
In another example, the LC tank is a tank formed by connecting a capacitor and an inductor in parallel, however, the LC tank may be of other types, which is not limited herein.
In yet another example, the pressure sensor is a pressure membrane sensor, although the pressure sensor may be of other types, and is not limited herein.
The technical scheme provided by the embodiment of the application has the following beneficial effects:
In the noninvasive intraocular pressure measurement system provided by the application, the intraocular pressure measurement device acquires the intraocular pressure measurement data and the intraocular pressure measurement data, and the ambient temperature is acquired from the ambient temperature acquisition device; the method comprises the steps of determining a plurality of capacitance drift amounts of a resonance circuit affected by humidity through intraocular humidity data and dielectric characteristics of equipment materials, converting all the capacitance drift amounts into frequency drift costs of resonance frequency in the resonance circuit when humidity changes each time, determining temperature-pressure regression coefficients of intraocular pressure of a target object based on linear regression characteristics between the intraocular pressure measurement data and the ambient temperature, performing cost fitting on all intraocular pressure measurement values in the intraocular pressure measurement data through the temperature-pressure regression coefficients to obtain temperature compensation costs of all intraocular pressure measurement values, adjusting the resonance frequency of the resonance circuit according to all the frequency drift costs and all the temperature compensation costs, and correcting the intraocular pressure measurement results of the target object based on the adjusted resonance frequency.
Therefore, in the method, firstly, after acquiring intraocular humidity data of a target object wearing intraocular pressure measuring equipment, determining the deviation degree (namely capacitance drift amount) of an actual capacitance value relative to a reference capacitance value caused by environmental humidity change through the intraocular humidity data and dielectric characteristics of equipment materials, thereby determining the influence degree (namely frequency drift cost) of each humidity change on the performance (namely resonant frequency) of a resonant circuit, secondly, after acquiring intraocular pressure measuring data of the target object wearing the intraocular pressure measuring equipment, determining a quantized value (namely temperature-pressure regression coefficient) of the influence degree of environmental temperature change on the eye pressure change, thereby evaluating the influence degree (cost fitting) of an external factor (such as environmental temperature change) on the measured data, and evaluating the deviation (temperature compensation cost) of the actual intraocular pressure value (intraocular pressure fitting value) through the quantized value of the influence degree, thereby adjusting the resonant frequency in the process of the target object wearing the intraocular pressure measuring equipment according to each frequency drift cost and each temperature compensation cost, and correcting the measurement result of the target object based on the adjusted resonant frequency.
Drawings
FIG. 1 is a schematic diagram of a non-invasive tonometric measurement system shown in accordance with some embodiments of the application;
fig. 2 is a schematic diagram showing the structure of an tonometer correction unit according to some embodiments of the present application;
Fig. 3 is a schematic diagram of a conversion module according to some embodiments of the application.
Detailed Description
In order to better understand the above technical solutions, the following detailed description will refer to the accompanying drawings and specific embodiments.
Referring to fig. 1, the non-invasive intraocular pressure measurement system according to some embodiments of the present application includes an intraocular pressure measurement device and a resonant circuit connected to the intraocular pressure measurement device, the resonant circuit is used for generating a resonant frequency corresponding to intraocular pressure, and the non-invasive intraocular pressure measurement system further includes an ambient temperature collection device and an intraocular pressure measurement correction unit, wherein the ambient temperature collection device is used for collecting ambient temperature when the target object wears the intraocular pressure measurement device, and the intraocular pressure measurement device is further used for collecting intraocular humidity data and intraocular pressure measurement data when the target object wears the intraocular pressure measurement device.
Referring to fig. 2, which is a schematic diagram of a tonometric correction unit according to some embodiments of the present application, in order to implement correction of non-invasive tonometric measurements, tonometric correction unit 100 may include an acquisition module 101, a transformation module 102, a fitting module 103, and a correction module 104, which are respectively described as follows:
The acquisition module 101 is mainly used for acquiring intraocular humidity data and intraocular pressure measurement data from the intraocular pressure measurement device, and acquiring the ambient temperature from the ambient temperature acquisition device.
The conversion module 102 is mainly used for determining a plurality of capacitance drift amounts of the resonance circuit after being affected by humidity according to the intraocular humidity data and the dielectric characteristics of equipment materials, so that all the capacitance drift amounts are converted into frequency drift cost of the resonance frequency in the resonance circuit when the humidity changes each time.
The fitting module 103, in the present application, the fitting module 103 is mainly configured to determine a temperature-pressure regression coefficient of the intraocular pressure of the target object based on a linear regression feature between the intraocular pressure measurement data and the ambient temperature, and further perform cost fitting on each intraocular pressure measurement value in the intraocular pressure measurement data through the temperature-pressure regression coefficient, so as to obtain a temperature compensation cost of each intraocular pressure measurement value.
The correction module 104 is mainly configured to adjust the resonant frequency of the resonant circuit according to each frequency drift cost and each temperature compensation cost, and correct the tonometric measurement result of the target object based on the adjusted resonant frequency.
In some preferred embodiments, referring to FIG. 3, the transformation module 102 may specifically include a feature determination sub-module and a drift cost determination sub-module;
the characteristic determination sub-module is used for determining dielectric characteristics of equipment materials through the intraocular humidity data;
The drift cost determination submodule is used for converting dielectric characteristics of equipment materials into frequency drift cost of resonant frequency in the resonant circuit when humidity changes each time.
In particular, the characteristic determination submodule can determine the humidity fluctuation amount of each intraocular pressure change according to the intraocular humidity data, and then determine the dielectric characteristics of the preparation material according to all the humidity fluctuation amounts.
In the method, the greater the fluctuation amount of the humidity represents the change degree of the intraocular humidity of the target object between different moments, the higher the fluctuation amount of the humidity represents the change degree of the intraocular humidity of the target object at the corresponding sampling moment, the smaller the fluctuation amount of the humidity represents the lower the change degree of the intraocular humidity of the target object at the corresponding sampling moment, and in particular, when the intraocular pressure change of each intraocular pressure is determined through the intraocular pressure data, the method can be realized in such a way that firstly, one intraocular pressure value in the intraocular pressure data is selected as a selected intraocular pressure value, then, the intraocular pressure humidity value of the selected intraocular pressure humidity value at the previous sampling moment in the intraocular pressure humidity data is obtained, finally, the difference value between the selected intraocular pressure humidity value and the intraocular pressure humidity value at the corresponding previous sampling moment is taken as the fluctuation amount of the intraocular pressure corresponding to the selected intraocular pressure humidity value, and the fluctuation amount of the residual intraocular pressure humidity value in the intraocular pressure humidity data is continuously determined, so that the intraocular pressure change of each time is obtained.
In the specific implementation, the dielectric characteristics of the standby material can be determined according to all humidity fluctuation amounts by firstly obtaining an environment dielectric constant and a humidity-dielectric influence coefficient, then multiplying each humidity fluctuation amount by the humidity-dielectric influence coefficient and adding the value of the environment dielectric coefficient as the relative dielectric constant corresponding to the humidity fluctuation amount, thereby obtaining the relative dielectric constant of the intraocular pressure measuring equipment material when the humidity in the eye of the target object changes each time, and taking all the relative dielectric constants as the dielectric characteristics of the equipment material.
It should be noted that, after the initial resonant frequency of the resonant circuit in the intraocular pressure measurement device is measured by the spectrum analyzer, the dielectric constant of the intraocular environment of the target object is calculated according to the relation between the initial resonant frequency and the dielectric constant, and the calculated dielectric constant is used as the environmental dielectric constant in the application, in other embodiments, the environmental dielectric constant can be determined by another method without limitation, in addition, the environmental dielectric constant is a physical quantity describing the response characteristic of the material to the electric field in the specific environment, reflects the capability of the material to store electric energy under the action of the electric field in the specific environment, and in addition, the relative dielectric constant is used for measuring the polarization degree of the material in the intraocular pressure measurement device, reflects the energy storage capability of the capacitor in the resonant circuit, and represents the influence degree of the change of the intraocular humidity of the target object on the electric field characteristic in the resonant circuit, and the higher the influence degree of the change of the intraocular humidity of the target object on the electric field characteristic in the resonant circuit is the lower the relative dielectric constant is the higher.
In addition, in specific implementation, the drift cost determination submodule can convert dielectric characteristics of equipment materials into a plurality of capacitance drift amounts of the resonant circuit after the resonant circuit is affected by humidity, and then convert all the capacitance drift amounts into frequency drift cost of resonant frequency in the resonant circuit when the humidity changes each time.
It should be noted that, the dielectric characteristics of the device material are converted into a plurality of capacitance drift amounts of the resonant circuit affected by humidity by the method that firstly, a dielectric variation coefficient and a reference capacitance value of the resonant circuit are obtained, then, one relative dielectric constant is selected as a selected relative dielectric constant, secondly, a product of the dielectric variation coefficient and the selected relative dielectric constant is used as an actual capacitance value corresponding to the selected relative dielectric constant, and finally, a difference value between the actual capacitance value and the reference capacitance value is used as a capacitance drift amount corresponding to the selected relative dielectric constant, and the capacitance drift amount corresponding to the residual relative dielectric constant is continuously determined.
It should be noted that the dielectric coefficient of variation in the present application describes the sensitivity of the relative dielectric constant to the capacitance in the resonant circuit, the greater the dielectric coefficient of variation, the greater the sensitivity of the relative dielectric constant to the capacitance in the resonant circuit, the lesser the dielectric coefficient of variation, the lower the sensitivity of the relative dielectric constant to the capacitance in the resonant circuit, in some preferred embodiments, the capacitance value of the resonant circuit after being affected by different humidity can be predicted by using the dielectric coefficient of variation obtained by experimental fitting under different humidity conditions, and the predicted value is compared with the actual measured value, so as to find the optimal dielectric coefficient of variation under different humidity conditions, and the optimal dielectric coefficient of variation can be obtained as the dielectric coefficient of variation in the present application, in other embodiments, without limitation, and preferably, the capacitance in the resonant circuit can be measured under stable temperature and humidity when the target object wears the intraocular pressure measuring device for the first time, and the measured result is used as the reference capacitance value in the present application.
In addition, the capacitance drift amount in the present application characterizes the degree of deviation of the actual capacitance value from the reference capacitance value due to the change in the ambient humidity, and the greater the capacitance drift amount, the higher the degree of deviation of the actual capacitance value from the reference capacitance value due to the change in the ambient humidity, and the smaller the capacitance drift amount, the lower the degree of deviation of the actual capacitance value from the reference capacitance value due to the change in the ambient humidity.
When the method is concretely implemented, all capacitance drift amounts are converted into frequency drift costs of resonant frequency in the resonant circuit when humidity changes each time, the method comprises the steps of firstly, obtaining inductance values of the resonant circuit, then selecting one capacitance drift amount as a selected capacitance drift amount, secondly, determining values of opening root numbers of multiplying ports of the inductance values and the selected capacitance drift amount, finally, multiplying the obtained result by reciprocal of 2 pi to be used as the frequency drift costs corresponding to the selected capacitance drift amount, and continuously determining the frequency drift costs corresponding to the residual capacitance drift amount, so that the frequency drift costs of the resonant frequency in the resonant circuit when humidity changes each time are obtained.
It should be noted that, in the present application, the frequency drift cost reflects the influence degree of humidity change on the performance (resonant frequency) of the resonant circuit, the larger the frequency drift cost is, the higher the influence degree of humidity change on the performance (resonant frequency) of the resonant circuit is, the smaller the frequency drift cost is, the lower the influence degree of humidity change on the performance (resonant frequency) of the resonant circuit is, as a preferred embodiment, the frequency drift cost of the resonant frequency in the resonant circuit when humidity changes each time is determined according to the inductance value and all the capacitance drift amounts, that is, firstly, one capacitance drift amount is selected as a selected capacitance drift amount, then, the value of multiplying the inductance value by the selected capacitance drift amount by the root number is determined, and finally, the obtained result is multiplied by the reciprocal of 2pi to be used as the frequency drift cost corresponding to the selected capacitance drift amount, and the frequency drift cost corresponding to the residual capacitance drift amount is continuously determined, thereby obtaining the frequency drift cost of the resonant frequency in the resonant circuit when humidity changes each time.
In some preferred embodiments, the fitting module 103 of the present application may include a modeling sub-module and a cost fitting sub-module, wherein
The modeling module is used for determining a temperature-pressure regression coefficient of the intraocular pressure of the target object based on the linear regression characteristic between the intraocular pressure measurement data and the ambient temperature;
and the cost fitting sub-module is used for performing cost fitting on all the intraocular pressure measured values in the intraocular pressure measured data through the temperature-pressure regression coefficient to obtain the temperature compensation cost of each intraocular pressure measured value.
In some embodiments, the modeling module may determine a linear regression model between the ambient temperature and the intraocular pressure of the target object according to the intraocular pressure measurement data and the ambient temperature data, where the linear regression model is a linear regression feature, and finally train the linear regression model to obtain a temperature-pressure regression coefficient of the intraocular pressure of the target object.
It should be noted that, in the present application, the linear regression model is a linear model between the measured tonometric data and the ambient temperature data, and characterizes a linear relationship between the tonometric data and the ambient temperature of the target object, and as a preferred embodiment, the linear regression model between the ambient temperature and the tonometric data of the target object is determined by the tonometric data and the ambient temperature, and the linear regression model, that is, a linear regression feature, may be implemented by first obtaining the ambient temperature data when the target object wears the tonometric device, then taking the tonometric data and the ambient temperature data as inputs, then using a linear regression model algorithm in the prior art to perform a linear model construction on the tonometric data and the ambient temperature data, and taking the obtained model as a linear regression model between the ambient temperature and the tonometric data of the target object in the present application, and in other embodiments, may be determined by another method, which will not be described here.
In addition, the temperature-pressure regression coefficient is a quantized value of the influence degree of the environmental temperature change on the eye pressure change, the larger the temperature-pressure regression coefficient is, the higher the influence degree of the environmental temperature change on the eye pressure change is, the smaller the temperature-pressure regression coefficient is, the lower the influence degree of the environmental temperature change on the eye pressure change is, as a preferable embodiment, the temperature-pressure regression coefficient of the target eye pressure obtained by training the linear regression model can be realized in such a way that firstly, an objective function is set according to the square error sum between the minimum actual eye pressure value and the predicted eye pressure value, then, the optimal model parameter is obtained for the objective function by adopting the least square method in the prior art, and the obtained optimal model parameter is used as the temperature-pressure regression coefficient of the target eye pressure in the application, and in other embodiments, the temperature-pressure regression coefficient of the target eye pressure can be determined by other methods without limitation.
Additionally, in some preferred embodiments, the cost fitting sub-module may determine a plurality of tonometric fit values from the ambient temperature data and the temperature-pressure regression coefficients, and then determine a temperature compensation cost for each tonometric measurement value from each tonometric measurement value and all tonometric fit values in the tonometric measurement data.
It should be noted that, since the intraocular pressure measurement result is affected by the expansion or contraction of the intraocular fluid caused by the change of the ambient temperature when the target object wears the intraocular pressure measurement device, the present application obtains the value that the intraocular pressure measurement value should reach after temperature-pressure regression correction by considering the influence of the ambient temperature on the intraocular pressure, that is, the intraocular pressure fitting value, preferably, determining a plurality of intraocular pressure fitting values according to the ambient temperature data and the temperature-pressure regression coefficient may be implemented by taking the product of each ambient temperature value in the ambient temperature data and the temperature-pressure regression coefficient as the intraocular pressure fitting value corresponding to the ambient temperature value, and in other embodiments, it may be determined by another method, which is not limited herein.
In particular, the temperature compensation cost of each of the tonometric measurements may be determined by selecting one of the tonometric measurements as the selected tonometric measurement, then using the difference between the selected tonometric measurement and the corresponding tonometric fitting as the temperature compensation cost of the selected tonometric measurement, and continuing to determine the temperature compensation cost of the remaining tonometric measurements to obtain the temperature compensation cost of each of the tonometric measurements.
In the present application, the cost fitting means that the degree of influence of an external factor (such as an environmental temperature change) on measured data is quantified, and the deviation of an actual intraocular pressure value (intraocular pressure fitting value) is estimated from the quantified value of the degree of influence, and the temperature compensation cost means the error amount of intraocular pressure measurement due to the environmental temperature change, which reflects the deviation between the actual measured intraocular pressure value (intraocular pressure measurement value) and the theoretical intraocular pressure value (intraocular pressure fitting value) after temperature correction, the larger the temperature compensation cost is, the larger the deviation between the actual measured intraocular pressure value (intraocular pressure measurement value) and the theoretical intraocular pressure value (intraocular pressure fitting value) after temperature correction is, the smaller the temperature compensation cost is, and the smaller the deviation between the actual measured intraocular pressure value (intraocular pressure measurement value) and the theoretical intraocular pressure value (intraocular pressure fitting value) after temperature correction is.
Additionally, in some embodiments, the correction module 104 of the present application may include an adjustment sub-module and an intraocular pressure correction sub-module, wherein
The adjusting submodule is used for adjusting the resonant frequency of the resonant circuit through the frequency drift cost and the temperature compensation cost;
the intraocular pressure correction submodule is used for correcting the intraocular pressure detection value through the adjusted resonant frequency and further outputting the corrected intraocular pressure value.
In particular, the adjusting sub-module can determine the frequency loss of the resonant circuit according to the frequency drift cost and the temperature compensation cost, and then adjust the resonant frequency of the resonant circuit according to the frequency loss.
It should be noted that, in the present application, the frequency loss of the resonant circuit may be determined by the frequency drift cost and the temperature compensation cost, which is implemented by firstly obtaining a coupling coefficient between the intraocular pressure and the resonant frequency of the target object, then selecting a frequency drift cost and a temperature compensation cost corresponding to one intraocular pressure measurement value, secondly multiplying the temperature compensation cost by the coupling coefficient, and then adding the frequency drift cost to obtain a frequency loss component corresponding to the one intraocular pressure measurement value, continuously determining a frequency loss component corresponding to the remaining intraocular pressure measurement value, and finally using an average value of all the frequency loss components as the frequency loss of the resonant circuit.
In addition, the coupling coefficient is a description amount of the influence of the change of the intraocular pressure of the target object on the resonance frequency of the eye pressure measuring device, the larger the coupling coefficient is, the larger the influence of the change of the intraocular pressure of the target object on the resonance frequency of the eye pressure measuring device is, the smaller the coupling coefficient is, the smaller the influence of the change of the intraocular pressure of the target object on the resonance frequency of the eye pressure measuring device is, as a preferred embodiment, the intraocular pressure of the target object can be set on a reference value by using an intraocular pressure simulator after the environment temperature and humidity are ensured to be stable through a method of experimental verification, the resonance frequency of the intraocular pressure measuring device at the moment is recorded, the intraocular pressure is gradually increased, the resonance frequency of the intraocular pressure measuring device is recorded each time, and the obtained result is used as the coupling coefficient in the application after the influence amount of the change of the intraocular pressure of the target object on the resonance frequency of the eye pressure measuring device is determined through all recorded data, and the obtained result can be obtained through other embodiments through other methods without limitation.
It should be noted that the frequency loss component characterizes the degree of fluctuation of the resonance frequency in the tonometer due to temperature influence (temperature compensation cost) and humidity influence (frequency drift cost) when the tonometer is measuring the tonometer, the higher the frequency loss component is, the higher the degree of fluctuation of the resonance frequency in the tonometer due to temperature influence (temperature compensation cost) and humidity influence (frequency drift cost) when the tonometer is measuring the tonometer is, the lower the degree of fluctuation of the resonance frequency in the tonometer due to temperature influence (temperature compensation cost) and humidity influence (frequency drift cost) is, and in addition, the frequency loss characterizes the stability of the resonance frequency due to environmental factors (temperature and humidity) when the tonometer is worn by the target object, the higher the frequency loss is, the lower the stability of the resonance frequency due to environmental factors (temperature and humidity) is, the stability of the resonance frequency due to environmental factors (temperature and humidity) is higher the stability of the resonance frequency is worn by the target object when the tonometer is worn by the target object.
In addition, in the tonometric data, each tonometric value has a unique corresponding resonant frequency in the resonant circuit, so that, in a specific implementation, the resonant frequency of the resonant circuit can be adjusted by using the frequency loss, that is, firstly, one tonometric value in the tonometric data is selected, then, the resonant frequency of the tonometric value is obtained, the resonant frequency is added with the frequency loss to be used as the adjusted resonant frequency of the tonometric value in the resonant circuit, and the adjusted resonant frequency of the remaining tonometric value in the resonant circuit can be continuously determined.
In the specific implementation, the intraocular pressure detection value is corrected through the adjusted resonant frequency, and then the corrected intraocular pressure value is output, namely, firstly, a coupling coefficient between the intraocular pressure and the resonant frequency is obtained, then, the result of multiplying the adjusted resonant frequency corresponding to each intraocular pressure measurement value by the coupling coefficient is used as a correction value corresponding to each intraocular pressure measurement value, and finally, the corrected correction value is output as a final intraocular pressure value.
In the noninvasive intraocular pressure measurement system, the influence of the intraocular pressure change of the target object on the resonance frequency of the intraocular pressure measurement device is determined, namely, after the coupling coefficient is obtained, the adjusted resonance frequency is used for correcting all intraocular pressure measurement values through the coupling coefficient, so that the intraocular pressure measurement result of the target object is corrected, namely, the intraocular pressure measurement values obtained by directly measuring the intraocular pressure measurement device are compensated by analyzing the influence of the ambient temperature of the target object when the intraocular pressure measurement device is worn by the target object and the influence of the intraocular humidity on the resonance frequency, and therefore the intraocular pressure detection precision is improved on the premise of noninvasive intraocular pressure measurement.
While preferred embodiments of the present application have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the application.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present application without departing from the spirit or scope of the application. Thus, it is intended that the present application also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. The noninvasive intraocular pressure measurement system comprises an intraocular pressure measurement device and a resonance circuit connected with the intraocular pressure measurement device, wherein the resonance circuit is used for generating resonance frequency corresponding to intraocular pressure, and the noninvasive intraocular pressure measurement system is characterized by further comprising an ambient temperature acquisition device and an intraocular pressure measurement correction unit, wherein the ambient temperature acquisition device is used for acquiring ambient temperature when a target object wears the intraocular pressure measurement device, and the intraocular pressure measurement device is also used for acquiring intraocular pressure humidity data and intraocular pressure measurement data when the target object wears the intraocular pressure measurement device;
the tonometric measurement correction unit specifically comprises an acquisition module, a conversion module, a fitting module and a correction module;
The acquisition module is used for acquiring intraocular humidity data and intraocular pressure measurement data from the intraocular pressure measurement equipment and acquiring the ambient temperature from the ambient temperature acquisition equipment;
The conversion module is used for determining a plurality of capacitance drift amounts of the resonant circuit after being affected by humidity through the intraocular humidity data and the dielectric characteristics of equipment materials, and further converting all the capacitance drift amounts into frequency drift cost of resonant frequency in the resonant circuit when the humidity changes each time;
the fitting module is used for determining a temperature-pressure regression coefficient of the intraocular pressure of the target object based on the linear regression characteristic between the intraocular pressure measurement data and the environmental temperature, and further performing cost fitting on each intraocular pressure measurement value in the intraocular pressure measurement data through the temperature-pressure regression coefficient to obtain a temperature compensation cost of each intraocular pressure measurement value;
The correction module is used for adjusting the resonance frequency of the resonance circuit according to each frequency drift cost and each temperature compensation cost, and correcting the intraocular pressure measurement result of the target object based on the adjusted resonance frequency.
2. The non-invasive tonometric measurement system of claim 1, wherein said conversion module comprises a feature determination sub-module and a drift cost determination sub-module;
the characteristic determination sub-module is used for determining dielectric characteristics of equipment materials through the intraocular humidity data;
The drift cost determination submodule is used for converting dielectric characteristics of equipment materials into frequency drift cost of resonant frequency in the resonant circuit when humidity changes each time.
3. The non-invasive tonometric measurement system of claim 1, wherein said fitting module comprises a modeling sub-module and a cost fitting sub-module;
a modeling module for determining a temperature-pressure regression coefficient of the target subject's intraocular pressure based on a linear regression feature between the intraocular pressure measurement data and an ambient temperature;
And the cost fitting sub-module is used for carrying out cost fitting on each intraocular pressure measured value in the intraocular pressure measured data through the temperature-pressure regression coefficient to obtain the temperature compensation cost of each intraocular pressure measured value.
4. The non-invasive tonometric measurement system of claim 1, wherein said correction module comprises an adjustment sub-module and a tonometric correction sub-module;
An adjusting sub-module, configured to adjust a resonant frequency of the resonant circuit according to the frequency drift cost and the temperature compensation cost;
and the intraocular pressure correction submodule is used for correcting the intraocular pressure detection value through the adjusted resonant frequency and further outputting the corrected intraocular pressure value.
5. The non-invasive tonometric measurement system of claim 1, wherein said tonometric measurement apparatus comprises a humidity sensor for detecting an intraocular humidity of a subject wearing said tonometric measurement apparatus, generating intraocular humidity data and transmitting to said tonometric measurement correction unit.
6. The non-invasive tonometric measurement system of claim 1, wherein said tonometric measurement apparatus comprises a flexible contact lens, said humidity sensor, resonant circuit, and ambient temperature acquisition apparatus being disposed within said flexible contact lens.
7. The non-invasive tonometric measurement system of claim 1, wherein said flexible contact lens is a hydrogel silica gel.
8. The non-invasive tonometric measurement system of claim 1, wherein said resonant circuit comprises a pressure sensor and an LC resonant tank.
9. The non-invasive tonometric measurement system of claim 1, wherein said LC resonant tank is a tank formed by a parallel connection of a capacitor and an inductor.
10. The non-invasive tonometric measurement system of claim 1, wherein said pressure sensor is a pressure membrane sensor.
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| CN202411943770.XA CN119837491A (en) | 2024-12-27 | 2024-12-27 | Noninvasive intraocular pressure measurement system |
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