CN119818774A

CN119818774A - Holding device for a storage container of a needleless syringe and needleless syringe

Info

Publication number: CN119818774A
Application number: CN202510025456.1A
Authority: CN
Inventors: 王琳; 赵利沙; 孙瑞倩; 孙景刚; 王世杰; 宗洧安
Original assignee: Beijing Qs Medical Technology Co ltd
Current assignee: Beijing Qs Medical Technology Co ltd
Priority date: 2025-01-07
Filing date: 2025-01-07
Publication date: 2025-04-15

Abstract

The present invention provides a holding device for a storage container of a needleless syringe, which is switchable between a locked state in which the holding device is capable of preventing the storage container from being mounted to or removed from a syringe body of the needleless syringe, and an unlocked state in which the holding device is capable of allowing the storage container to be mounted to or removed from the syringe body, the holding device comprising an operable member operated by an operator to switch the locked state and the unlocked state, and a linkage mechanism that switches between a first state and a second state in response to operating the operable member. A needleless injector comprising the holding device is also provided. According to the holding device and the needleless injector of the present invention, the built-in medicine storage bottle can be freely installed and taken out in the injector, and the taking and placing of the built-in medicine storage bottle can be easily realized without using a separate tool, thereby providing convenience for an operator to use the needleless injector.

Description

Holding device for a storage container of a needleless syringe and needleless syringe

Technical Field

The present invention relates to medical devices for injecting substances to be injected, in particular needleless injectors for injecting liquid medicines. More particularly, the present invention relates to a holding device for a storage container of a needleless syringe and a needleless syringe.

Background

In medical situations, when using a needleless injector, it is often necessary to first mount a cartridge for containing the substance to be injected onto the injector body, then withdraw the substance to be injected from a separately placed drug storage vial through the distal end of the cartridge, and after withdrawal, separate the distal end of the cartridge from the drug storage vial for injection. The operation flow of the injector in the mode is complex, the skill requirement on an operator is high, and the injector is usually operated by a professional medical staff and is not suitable for being used as a household injector for common people to operate at home.

To address this problem, existing solutions have been to modify the syringe structure and modify the conventional external drug storage vial into an internal drug storage vial so as to be able to be accommodated within the syringe body. In operation, a drug sucking process is performed first, and the substance to be injected is sucked into the accommodating cavity from the drug storage bottle in the syringe main body through the proximal end of the drug tube by the movement of the piston rod in the drug tube, and then injection is completed.

However, such built-in medicine storage vials are generally only installed in or removed from the syringe body along with the syringe head including the medicine tube and the piston rod, and when the medicine storage vial needs to be replaced, it is difficult for the operator to flexibly take and put the medicine storage vial separately, resulting in difficulty in changing the medicine.

Accordingly, there is a need to provide a retaining device for a drug storage vial of a needleless injector to retrofit existing needleless injectors so that the drug storage vial can be freely installed and removed therein to at least partially solve the above-described problems of existing needleless injectors.

Disclosure of Invention

In order to overcome the above-mentioned drawbacks of the prior art, and to facilitate the free replacement of a built-in drug vial in a needleless syringe, according to one aspect of the present invention, there is provided a holding device for a storage container of a needleless syringe, the storage container being removably mountable in the needleless syringe, the holding device being configured to be switchable between a locked state and an unlocked state, wherein in the locked state the holding device is capable of preventing the storage container from being mounted to or removed from a syringe body of the needleless syringe, and in the unlocked state the holding device is capable of allowing the storage container to be mounted to or removed from the syringe body, wherein the holding device comprises an operable member operable by an operator to move between a locked position and an unlocked position of the operable member to switch the holding device between the locked state and the unlocked state, and a linkage is configured to be switchable between a first state and a second state in response to movement of the operable member between the locked position and the unlocked position, wherein in the linkage is in the first state and the unlocked state the operable member is in the first state or the second state the linkage is allowed to be mounted to or removed from the syringe body.

In some preferred embodiments, the linkage is held by a tubular first internal ram within the outer housing of the syringe body, and wherein the storage container is receivable within the interior of the first internal ram.

In some preferred embodiments, the linkage mechanism includes a stop mechanism configured to move between a first position and a second position in response to movement of the operable member between the locked position and the unlocked position, and a blocking mechanism configured to switch between a blocking state and a non-blocking state in response to movement of the stop mechanism between the first position and the second position, wherein when the stop mechanism is in the first position, the blocking mechanism is in the blocking state, the blocking mechanism in the blocking state is capable of interfering with the storage container in a radial direction to prevent the storage container from being mounted to or removed from the syringe body, and wherein when the stop mechanism is in the second position, the blocking mechanism in the non-blocking state does not interfere with the storage container to allow the storage container to be mounted to or removed from the syringe body.

In some preferred embodiments, the operable component is disposed on the outer housing and is configured as a push-type operable component.

In some preferred embodiments, the spacing mechanism is configured to move in the axial direction between the first position and the second position in response to movement of the operable member in the axial direction between the locked position and the unlocked position.

In some preferred embodiments, the operable member is mountable in a recess of a circumferential side wall of the outer housing of the syringe body, and the operable member is movable in the recess in the axial direction relative to the outer housing between the locked position and the unlocked position.

In some preferred embodiments, the operable component includes a base extending in an axial direction, an operator engagement portion configured to extend outwardly in a radial direction from a radially outer surface of the base and engageable by an operator to operate the operable component between a locked position and an unlocked position, a slide portion configured to extend inwardly in the radial direction from a radially inner surface of the base and a radially inner surface of the slide portion is contactable with a radially outer surface of a bottom wall of the recess of the outer housing to move in the axial direction on the surface, and a protrusion configured to extend inwardly in the radial direction from the radially inner surface of the slide portion and protrude from an opening in a corresponding position of the bottom wall of the recess toward a radially inner side of the outer housing, the opening extending in the axial direction and allowing the protrusion to move in the axial direction therein, and wherein the protrusion is engageable with the linkage mechanism to switch between the first state and the second state in response to movement of the protrusion in the axial direction in the opening of the recess.

In some preferred embodiments, the sliding portion of the operable member includes a columnar member extending in the axial direction, and an end wall of the recess perpendicular to the axial direction is provided with a hole aligned with the columnar member, and wherein the holding device further includes a first spring extending in the axial direction, the first spring including a first end portion received and restrained within the hole of the end wall of the recess, and a second end portion sleeved on an outer peripheral side of the columnar member, wherein the first spring is configured to be able to bias the operable member toward the locking position by the columnar member.

In some preferred embodiments, the locked position of the operable member is positioned distally relative to the unlocked position, wherein the columnar member extends proximally from the proximal end surface of the slide, a bore is open in the proximal end wall of the recess, and wherein the first spring is configured to bias the operable member distally toward the locked position through the columnar member.

In some preferred embodiments, the holding device further comprises a first guide engagement portion extending in the axial direction provided in the recess of the outer housing, wherein the sliding portion of the operable member comprises a second guide engagement portion extending in the axial direction, and wherein the first guide engagement portion and the second guide engagement portion are configured to be able to cooperate with each other to guide the movement of the sliding portion of the operable member in the recess of the outer housing.

In some preferred embodiments, the first guide engagement portion is configured to include at least one guide post fixedly disposed in the recess of the outer housing, and the second guide engagement portion is configured to include at least one through-hole opening in the sliding portion extending therethrough in the axial direction, each through-hole being in a form-fit with a corresponding guide post, thereby allowing the sliding portion to move in the axial direction by axial movement of each through-hole over the corresponding guide post.

In some preferred embodiments, both ends of each guide post in the axial direction are respectively received and fixed in two U-shaped fixing pieces extending outward in the radial direction from the radially outer surface of the bottom wall of the recess, the two U-shaped fixing pieces being configured to restrict the movement of the guide post in common.

In some preferred embodiments, the number of the through holes of the sliding portion is two, the two through holes are respectively opened at positions near both end portions of the sliding portion parallel to the axial direction, and accordingly, the number of the guide posts is two, and the two guide posts are respectively located at positions on the recessed portion corresponding to circumferential positions of the two through holes of the sliding portion.

In some preferred embodiments, the blocking mechanism comprises a first annular member comprising a blocking portion open with a through bore extending in a radial direction, the through bore receiving the ball therein, wherein the diameter of the through bore is not smaller than the ball to allow the ball to move back and forth in the radial direction along an inner wall surface of the through bore, and wherein the through bore comprises a first open end located radially inward, a second open end located radially outward, and an annular first flange extending from the inner wall surface of the through bore inward of the through bore at the first open end, the first flange being sized to allow at least a portion of the ball to protrude radially inward from the first open end of the through bore while preventing continued movement of the ball radially inward out of the through bore.

In some preferred embodiments, the stop mechanism comprises a second annular member sleeved on the outer peripheral side of the first annular member, the second annular member being configured to be movable in the axial direction between a first position and a second position in response to movement of the projection in the axial direction in the opening of the recess of the outer housing, wherein the second annular member comprises an annular second flange extending radially inward from an inner wall surface of the second annular member, wherein when the second annular member is in the first position, the second flange is aligned in the axial direction with the through hole of the blocking mechanism and a radially inner side surface of the second flange abuts the ball in the through hole of the blocking mechanism to force at least a portion of the ball to protrude radially inward from the first open end of the through hole to interfere with each other in the radial direction with the storage container, and wherein when the second annular member is in the second position, the second flange is staggered in the axial direction with the through hole of the blocking mechanism to allow the ball to move freely radially outward to a position that does not protrude radially inward from the first open end of the through hole to the radially inner side to thereby not interfere with the storage container.

In some preferred embodiments, the proximal end of the first annular component is configured to be secured to the distal end of the first inner push rod.

In some preferred embodiments, the first position is distal relative to the second position, wherein the stop mechanism further comprises a second spring positioned between the first annular member and the second annular member and nested on an outer peripheral side of the first annular member, wherein a proximal end of the second spring abuts a distal end surface of the first inner push rod and a distal end of the second spring abuts a proximal surface of a second flange of the second annular member, and wherein the second spring is configured to bias the second annular member toward the distal first position through the proximal end surface of the second flange.

In some preferred embodiments, the proximal end of the first annular component is formed with external threads and the distal end of the first inner push rod is formed with internal threads that mate with the external threads of the first annular component.

In some preferred embodiments, the distal side of the second flange of the second annular member is formed with a bevel, wherein the ball is movable along the bevel of the second flange to a position no longer protruding radially inward from the first open end of the through hole during proximal movement of the second annular member in the axial direction from the first position to the second position.

In some preferred embodiments, the second annular member further comprises a third flange located at a distal portion of the second annular member extending radially inward from an inner wall of the second annular member, wherein the second flange is located proximal to the third flange and the second flange is located between the third flanges forming a first annular groove configured to at least partially receive the ball when the second annular member is in the second position.

In some preferred embodiments, the first annular member includes a plurality of circumferentially distributed through holes, each of which accommodates a ball therein.

In some preferred embodiments, the plurality of through holes are equally spaced.

In some preferred embodiments, the holding device further comprises a base for holding the storage container, the base being located proximal to the storage container and configured to form-fit with a proximal end of the storage container for receiving and holding the proximal end of the storage container.

In some preferred embodiments, the retaining device further comprises a third spring configured to be positioned between the base and a tubular second inner push rod within the outer housing of the syringe body, the second inner push rod configured to be proximal to the first inner push rod and fixed to each other with the first inner push rod, wherein the third spring is configured to bias the base distally in the axial direction.

In some preferred embodiments, the second inner pushrod comprises a first axial extension comprising an elongated first through slot opening on the sidewall extending in an axial direction, the first through slot extending to a distal end of the first axial extension, and a second axial extension extending distally from the distal end of the first axial extension, wherein a fourth flange extending radially inward from an inner wall surface of the first axial extension is provided at a substantially intermediate location in the axial direction of the first axial extension, and wherein the second axial extension is adapted to engage a proximal end of the first inner pushrod to secure the first inner pushrod to each other.

In some preferred embodiments, the base includes a third axial extension, a distal portion of the third axial extension being provided with a distally extending tab corresponding in position to the first channel of the second internal push rod so as to be movable in an axial direction within the first channel, and a fourth axial extension extending distally from a distal end of the third axial extension.

In some preferred embodiments, the proximal end of the third spring abuts a distal surface of the fourth flange of the second inner push rod, and the distal end of the third spring abuts an inner stepped surface of the connection region between the third and fourth axial extensions of the base extending perpendicular to the axial direction, whereby the base can be biased distally in the axial direction by the inner stepped surface.

In some preferred embodiments, the storage container comprises a distally located drug storage region and an annular engagement region extending proximally from a proximal end of the drug storage region, the engagement region being held between the tab of the third axial extension and the fourth axial extension of the base, and wherein the proximal end of the engagement region abuts an external stepped surface of the connection region between the third axial extension and the fourth axial extension of the base extending perpendicular to the axial direction, such that the storage container can be pushed out of the syringe body following the base by the third spring when an operator operates to unlock the holding device.

In some preferred embodiments, the second axial extension of the second inner push rod is provided with internal threads and the proximal end of the first inner push rod is provided with external threads that mate with the internal threads of the second axial extension.

In some preferred embodiments, the first axial extension of the second inner push rod includes a plurality of first through slots, and the third axial extension of the base includes a plurality of tabs corresponding in location to and in the same number as the first through slots.

In some preferred embodiments, the inner wall surface of the proximal end of the first inner push rod is provided with a second annular groove in which a rubber ring contacting the outer peripheral side surface of the storage container is received, the rubber ring being for preventing movement of the storage container.

In some preferred embodiments, the first annular member further comprises an engagement portion distal to the blocking portion for engaging the piston rod of the injection head to mutually fix the piston rod.

In some preferred embodiments, the engagement portion of the first annular member is formed with a third annular groove near the distal end of the first annular member, and wherein the proximal end of the piston rod is provided with an elastic snap-fit portion extending proximally in the axial direction, the snap-fit portion being snapable to the distal end face of the third annular groove such that the piston rod and the first annular member are fixed to each other.

In some preferred embodiments, the stop mechanism comprises a slip ring member disposed in the first inner push rod and sleeved on the storage container, the slip ring member being movable in the axial direction relative to the storage container between a first position and a second position in response to movement of the operable member in the axial direction between the locked position and the unlocked position, wherein the slip ring member comprises a distal cylindrical portion, an outer peripheral side wall of which is disposed with a tab that is engageable with the operable member to move in the axial direction in a correspondingly disposed recess in an inner wall surface of the first inner push rod under the urging of the operable member to guide movement of the slip ring member in the axial direction, and a proximal frustoconical portion for engaging the blocking mechanism to switch the blocking mechanism between the blocking state and the non-blocking state.

In some preferred embodiments, the blocking mechanism is positioned proximally of the stop mechanism and comprises an elastic ring tab member disposed in the first inner push rod and sleeved over the storage container, the elastic ring tab member being engageable with the frustoconical portion of the distal slip ring member, and a mounting member for fixedly mounting the elastic ring tab member to the first inner push rod, the mounting member comprising a distal tubular element and a proximal annular stop element, wherein the tubular element is captured in a correspondingly disposed securing slot in the first inner push rod and is fixedly connectable with the elastic ring tab member, and wherein the annular stop element is disposed proximally of the tubular element for limiting axial movement of the tubular element.

In some preferred embodiments, the elastic ring-like member comprises a plurality of elastic elements arranged consecutively in a circumferential direction, each elastic element comprising a fixation portion located radially outside for fixing the elastic element to the distal edge of the tubular element, and a deformable portion capable of being elastically deformed such that the angle between the deformable portion and the fixation portion is switched between a first angle and a second angle.

In some preferred embodiments, the frustoconical portion does not engage the annular member when the slip ring member of the spacing mechanism is in the first distal position, the angle between the deformable portion and the fixed portion of each of the plurality of resilient elements is a first angle at which the radially inner end of the deformable portion contacts and interferes with the storage container, and the frustoconical portion biases the deformable portion of each of the plurality of resilient elements radially outward when the slip ring member of the spacing mechanism is moved proximally to the second position, such that the angle between the deformable portion and the fixed portion of each of the plurality of resilient elements is converted from the first angle to a second angle at which the radially inner end of the deformable portion does not contact the storage container, and wherein the first angle is greater than the second angle.

In some preferred embodiments, radially inner ends of the deformable portions of the plurality of elastic elements collectively form an opening of the elastic annular member, wherein the opening has a first diameter when the angle between the deformable portion and the fixed portion of each of the plurality of elastic elements is a first angle, wherein the opening has a second diameter when the angle between the deformable portion and the fixed portion of each of the plurality of elastic elements is a second angle, and wherein the second diameter is greater than the first diameter.

In some preferred embodiments, the tab includes a hole configured to be engaged by a lever of the operable component.

In some preferred embodiments, the first inner push rod is provided with a second through slot at a location corresponding to the tab, the second through slot allowing the aperture of the tab to be exposed to the lever when the slip ring member is moved between the first and second positions.

In some preferred embodiments, the cylindrical portion of the slip ring component comprises two symmetrically arranged lugs and, correspondingly, the first inner push rod comprises two symmetrically arranged second through slots thereon.

In some preferred embodiments, the operable component is arranged on the outer housing and is configured as a push-type operable component, and the linkage includes a swing link and a resilient element that are housed inside and held by the first inner push rod.

In some preferred embodiments, the circumferential side wall of the first inner push rod is provided with a through slot for receiving and retaining the swing link and the resilient element, wherein the swing link is pivotally mounted to the through slot, at a position near the distal end.

In some preferred embodiments, the swing link includes a pin disposed at a substantially middle position of the swing link, the swing link being mounted to the through slot by the pin, wherein the through slot includes two opposite side walls extending in an axial direction, each side wall having a mounting hole formed therein for receiving and securing an end of the pin, and wherein the swing link is pivotable in the through slot about the pin.

In some preferred embodiments, the swing link includes a first leg proximal to the pin and a second leg distal to the pin, wherein one of the first and second legs is switchable from a first state radially interfering with the storage container to a second state not interfering with the storage container in response to the operable member being pressed by the operator to move from the locked position toward the unlocked position.

In some preferred embodiments, the second leg of the swing link is switchable from a first state radially interfering with the storage container to a second state not interfering with the storage container in response to the operable member being pressed by the operator to move from the locked position toward the unlocked position, and wherein the second leg of the swing link includes a protrusion extending from a radially inner surface of the second leg in a radially inner direction, the protrusion being configured to radially interfere with the storage container when the second leg of the swing link is in the first state and not interfering with the storage container when the second leg is in the second state.

In some preferred embodiments, the resilient element is configured to bias the second leg of the pendulum towards a first state radially interfering with the storage container.

In some preferred embodiments, the through slot of the first inner push rod for receiving and holding the swing link is a third through slot comprising a proximal first portion and a distal second portion having a width smaller than the first portion, wherein the resilient element is arranged between a radially outer side surface of the second leg of the swing link and a radially inner side surface of a circumferential side wall of the first inner push rod at the second portion of the third through slot and is capable of biasing the second leg of the swing link in a radially inner direction towards a position radially interfering with the storage container.

In some preferred embodiments, the operable member is capable of engaging the first leg of the swing link to allow the first leg of the swing link to move in a radially inward direction when the operator presses the operable member such that the swing link pivots about the pin against the biasing force of the resilient element to a position where the protrusion of the second leg of the swing link does not interfere with the storage container.

In some preferred embodiments, the second portion of the third channel includes a bottom wall configured such that a distal end of the second leg of the pendulum rod is capable of overlapping the bottom wall when the second leg is in the first state, and wherein the bottom wall does not contact the protrusion of the pendulum rod.

In some preferred embodiments, the first and second legs of the pendulum rod extend substantially parallel to each other.

In some preferred embodiments, the first leg of the swing link is switchable from a first state radially interfering with the storage container to a second state not interfering with the storage container in response to the operable member being pressed by the operator to move from the locked position toward the unlocked position, and wherein the proximal end of the first leg of the swing link is configured to radially interfere with the storage container when the first leg of the swing link is in the first state and to not interfere with the storage container when the first leg is in the second state.

In some preferred embodiments, the resilient element is configured to bias the second leg of the pendulum rod towards a radially outward direction such that the pendulum rod pivots about the pin rod at a position where a proximal end of the first leg of the pendulum rod is configured to radially interfere with the storage container.

In some preferred embodiments, the through slot of the first inner push rod for receiving and retaining the swing link is a fourth slot comprising a proximal first portion and a distal second portion, wherein the first portion of the fourth slot allows the first leg of the swing link to pass therethrough and radially interfere with the storage container, and wherein the second portion of the fourth slot is provided with a bottom wall between which the resilient element is retained and a radially inner surface of the second leg of the swing link.

In some preferred embodiments, the operable member is configured to engage the second leg of the swing link such that when the operator presses the operable member, the second leg of the swing link is configured to move radially inward against the biasing force of the resilient element such that the swing link pivots about the pin to a position where the proximal end of the first leg of the swing link does not interfere with the storage container.

In some preferred embodiments, the first leg and the second leg of the rocker form an obtuse angle therebetween in a radially inward direction.

In some preferred embodiments, one or more through slots are provided in the circumferential side wall of the first inner push rod in the circumferential direction, each through slot accommodating and retaining the swing link and the resilient element.

In some preferred embodiments, the elastic element is an extension spring.

In some preferred embodiments, the operable member is arranged on the outer housing and is configured as a push-type operable member, wherein the stop mechanism is configured to be movable in a vertical radial direction between an upper first position and a lower second position in response to movement of the operable member in the vertical radial direction between the locked position and the unlocked position, and wherein the blocking mechanism is configured to be switchable between a closed blocking state and an open non-blocking state in response to movement of the stop mechanism between the first position and the second position.

In some preferred embodiments, the spacing mechanism includes a snap ring that is engageable by the operable member such that when the operator presses down on the operable member, the snap ring moves downward.

In some preferred embodiments, the snap ring is capable of being sleeved over the storage container radially outward of the storage container, wherein the snap ring comprises a top portion engageable by the operable member and two arm portions extending from the top portion toward both sides in a circular arc shape as a whole, an end portion of each of the two arm portions remote from the top portion comprising a guide groove for engaging and guiding movement of the blocking mechanism, and wherein the guide groove extends in a horizontal radial direction.

In some preferred embodiments, the first inner push rod is formed with a clamping groove for receiving the clamping ring, the clamping groove matching the shape of the clamping ring such that the clamping ring is movable in the clamping groove in a vertical radial direction between a first position and a second position, wherein the clamping groove comprises two guiding portions extending in the vertical radial direction, each guiding portion receiving one of two ends of the two arms of the clamping ring distal to the top portion and allowing the end to move up and down in the vertical radial direction therein.

In some preferred embodiments, the catch of the first inner push rod includes a first tongue extending distally from a proximal surface of the catch extending perpendicular to the axial direction, the first tongue being located directly below the top of the snap ring.

In some preferred embodiments, the stopper mechanism further includes an elastic element that abuts between a hole opened in a bottom surface of the top of the snap ring and a top surface of the first tongue, and is configured to bias the snap ring upward.

In some preferred embodiments, the blocking mechanism comprises two swing arms that are generally arcuate in shape, each swing arm being pivotably coupled to the first inner push rod by a bottom end of the swing arm.

In some preferred embodiments, the substantially central position of each swing arm is provided with a guide pin movable along a guide slot of the arm portion of the snap ring on the same side, wherein when the snap ring is in the upper first position, each guide pin is located at a radially inner end of the corresponding guide slot such that the two swing arms together form a closed blocking condition in which the two swing arms radially interfere with the storage container, and wherein when the operator presses the operable member such that the snap ring moves downwardly to the second position, the snap ring moves the corresponding guide pin through each guide slot to the radially outer end of the guide slot such that the two swing arms move radially outwardly to together form an open non-blocking condition in which the two swing arms do not interfere with the storage container.

In some preferred embodiments, the retaining device further comprises an annular stop element for limiting the axial position of the blocking mechanism and the stop mechanism.

In some preferred embodiments, the stop element is located distally of the blocking mechanism and stop mechanism to prevent distal movement of the blocking mechanism and stop mechanism out of the first inner push rod.

In some preferred embodiments, the blocking mechanism is located distally of the spacing mechanism, and the spacing element includes a proximally extending annular flange capable of distally abutting the two swing arms, and a second tongue extending proximally beyond the annular flange capable of distally abutting a top of the snap ring when the snap ring is in the first position above.

According to a further aspect of the present invention there is provided a needleless injector comprising an injector body and a storage container located within an outer housing of the injector body, the storage container being removably mountable in the needleless injector, wherein the injector body comprises an outer housing and a tubular first inner push rod within the outer housing, characterised in that the needleless injector further comprises a retaining means for the storage container according to any of the preceding aspects, the retaining means being configured to prevent the storage container from being mounted to or removed from the needleless injector in a locked condition, or to allow the storage container to be mounted to or removed from the needleless injector.

In some preferred embodiments, the needleless injector further comprises an injection head removably mountable to the injector body, a distal end of the injection head comprising injection micropores.

In some preferred embodiments, the storage container is a carafe.

In some preferred embodiments, the linkage is held by a tubular first inner push rod within the outer housing of the syringe body, and the storage container is receivable inside the first inner push rod, wherein the first inner push rod comprises a first hollowed-out portion formed on the circumferential side wall, and the outer housing comprises a second hollowed-out portion aligned in the circumferential direction with the first hollowed-out portion, the first hollowed-out portion and the second hollowed-out portion together forming a visual window for an operator to view the storage container.

In some preferred embodiments, the operable component is mountable to a recess of a circumferential side wall of the outer housing of the syringe body, and the first hollowed out portion and the second hollowed out portion have an elongated shape extending in the axial direction, and wherein the second hollowed out portion is located proximal to the recess.

In some preferred embodiments, the needleless injector further comprises a cap engageable with the outer housing of the needleless injector to cover the recess and the second hollowed-out portion, and wherein the cap comprises a window through which the operator-engaging portion of the operable component can be exposed to an operator when the cap is capped on the outer housing.

By means of the holding device and the needleless injector according to the invention, the built-in medicine storage bottle can be freely installed and taken out in the injector, and the taking and placing of the built-in medicine storage bottle can be easily realized without using a separate tool, so that convenience is brought to an operator in using the needleless injector.

Drawings

For a better understanding of the above and other objects, features, advantages and functions of the present invention, reference should be made to the preferred embodiments illustrated in the accompanying drawings. The same or similar reference numbers in the drawings refer to the same or similar parts. It will be appreciated by persons skilled in the art that the drawings are intended to schematically illustrate preferred embodiments of the invention, and that the scope of the invention is not limited in any way by the drawings, and that the various components are not drawn to scale.

Fig. 1 shows a perspective view of a needleless injector according to a preferred embodiment of the present invention.

Fig. 2 shows an exploded view of the needleless injector of fig. 1.

Fig. 3 shows an exploded view of the components associated with the injection head of the needleless injector of fig. 1.

Fig. 4-6 show perspective views of components inside the outer housing of the needleless injector of fig. 1.

Fig. 7 shows a schematic view of the mating of the outer housing and cap of the needleless injector of fig. 1.

Fig. 8-9 illustrate schematic views of a distal portion of the outer housing of the needleless injector of fig. 1, showing a recess of the outer housing mated with the cap.

Fig. 10 shows a perspective view of the operable components of the holding device for the needleless syringe of fig. 1, in accordance with a preferred embodiment of the present invention.

Fig. 11 shows a perspective view of a linkage mechanism for the holding device of the needleless syringe of fig. 1, in accordance with a preferred embodiment of the present invention.

Fig. 12 to 13 show perspective views of the blocking mechanism of the linkage shown in fig. 11.

Fig. 14 shows a perspective view of the spacing mechanism of the linkage shown in fig. 11.

Fig. 15A to 15B are schematic views showing the linkage mechanism shown in fig. 11 in a first state and a second state, respectively.

Fig. 16A to 16B show partial enlarged views of the linkage mechanism in fig. 15A to 15B, respectively.

Fig. 17 shows a perspective view of a second inner push rod according to a preferred embodiment of the present invention.

Fig. 18 shows a perspective view of a base of a storage container according to a preferred embodiment of the present invention.

Fig. 19 shows a perspective view of the base of the storage container according to the preferred embodiment of the present invention, viewed from another direction.

Fig. 20 to 22 show schematic views of a holding device according to another preferred embodiment of the present invention.

Fig. 23 to 25 show schematic views of a holding device according to a further preferred embodiment of the invention.

Fig. 26 to 29 show schematic views of a holding device according to a further preferred embodiment of the invention.

Fig. 30 to 36 show schematic views of a holding device according to a further preferred embodiment of the invention.

Detailed Description

Hereinafter, a holding device for a storage container and a needleless syringe provided with the holding device according to the present invention will be described in detail with reference to the accompanying drawings. What follows is merely a preferred embodiment according to the present invention, and other ways of implementing the invention will occur to those skilled in the art on the basis of the preferred embodiment, and are within the scope of the invention.

The present invention provides a holding device for a storage container that can be removably mounted in and used with a needleless syringe. The retaining device is configured to be switchable between a locked state in which the retaining device is capable of preventing the storage container from being mounted to or removed from the syringe body of the syringe, and an unlocked state in which the retaining device is capable of allowing the storage container to be mounted to or removed from the syringe body.

In order to better describe the holding device according to the invention and to facilitate understanding, the overall structure of the needleless injector is first described.

First, it should be noted that the directional terms and positional terms referred to in the present invention should be understood as relative directions and relative positions. The directional terms and positional terms referred to herein may be understood with reference to the accompanying drawings. For example, references to "axial," "axial direction (X)" and the like in the present invention may be understood to refer to directions parallel or substantially parallel to the longitudinal center axis of the syringe, i.e., directions along or parallel to the X-X direction in the drawings, "radial," "upper," "lower," "circumferential direction" and the like in the present invention are all directions defined with respect to the X-X axis, e.g., radially outer direction means a direction away from the longitudinal center axis of the syringe, radially inner direction means a direction toward the longitudinal center axis of the syringe, up-and-down movement means a back-and-forth movement in a particular radial direction, and circumferential direction means a direction about the longitudinal center axis of the syringe, and references to "rotational direction" in the present invention may be understood to refer to a direction about the X-X axis, which is substantially equivalent to "circumferential direction". References herein to "proximal", "proximal direction", "rear end", "rear direction", etc. are directions along or parallel to the axis X-X that are near the hand of the operator (considering that the operator holds the syringe for aspiration and injection); the terms "distal", "distal direction", "front end", "front direction", etc. as used herein refer to a direction away from the operator's hand in the direction along or parallel to the axis X-X, as well as the direction in which the substance to be injected is ejected during the injection step.

Integral structure

Fig. 1 illustrates an overall perspective view of a needleless injector in accordance with some preferred embodiments of the present invention, and fig. 2 illustrates an exploded schematic view of the injector illustrated in fig. 1. The injector in this embodiment is a needleless injector, unlike a conventional needleless injector, the needleless injector does not inject through a needle, but is provided with injection micropores at the distal-most end of an injection head, through which an injection object is rapidly ejected to be injected into a patient during injection. It should be noted that the concept of the present invention is described herein by taking medicine, liquid medicine, etc. as examples, but this is merely an example and not a limitation. The injection subject may be of various other types, such as physiological saline, glucose, solid particles, etc., and any injection subject capable of being injected into a human body by the needleless injector of the present invention falls within the scope of the present invention, and the present invention is not limited to the form and kind of the injection subject.

Referring to fig. 1 to 6, a syringe 1 according to the present preferred embodiment includes an injection head 2, a syringe body 3, and a storage container 4. The components can be packaged separately before use and reassembled together for use.

The injection head 2 includes a cartridge 21 for accommodating a drug solution to be injected sucked from the storage container 4, an end cap 23 which can be removably fitted with a distal portion of the cartridge so as to hold the cartridge in a state of covering the injection micro-hole of the distal end of the cartridge during a drug sucking process described below and to be removed to expose the injection micro-hole during the injection process, and a piston rod 22 which can move inside the cartridge 21 in the axial direction X with respect to the cartridge 21 to suck the drug solution in the storage container 4 into the cartridge during the drug sucking process and push out the drug solution to be injected in the cartridge 21 through the injection micro-hole of the cartridge during the injection process so that the drug solution is ejected through the micro-hole to complete the injection. The storage container 4 may be a container storing a medicine, for example, a card bottle according to the national standard. The storage container 4 according to the present invention is built-in and can be removably mounted into the syringe 1, in particular in the syringe body 3, for use with the syringe body 3 and the injection head 2.

The syringe body 3 includes an outer housing 32, a rear housing 31, a first inner push rod 33, and a second inner push rod 34. The outer housing 31 accommodates the various components within the syringe body and is provided with external threads at its proximal end for inter-engagement with internal threads at the distal end of the rear housing 31 so that an operator can make axial relative movement between the two by rotating either the rear housing 31 or the outer housing 32. Referring to fig. 2, 4 and 5, the outer housing 32 accommodates a first inner push rod 33 and a second inner push rod 34 located proximally of the first inner push rod, wherein the first inner push rod 33 is adapted to accommodate the storage container 4 for carrying the storage container for movement during the entire operation. The two inner push rods 33, 34 are fixed to each other (for example, by screw engagement), and can be locked to or unlocked from the rear housing 31 by engagement between a locking member (not shown) located on the proximal side of the second inner push rod 34 and a locking mechanism 35 (the locking mechanism 35 is fixedly provided on the rear housing 31).

The injector head 2 may be removably mounted to the injector body 3. In particular, referring to fig. 2 and 3, the cartridge 21 of the injector head 2 may be fixedly mounted to the outer housing 32, for example by mating between external threads of a proximal portion of the cartridge 21 and internal threads of the outer housing 32 proximate to the distal opening. During the whole operation after the fixing and mounting, the medicine tube 21 is kept in a mutually fixed state with the outer shell 32, and the movement of the medicine tube 21 is driven by the outer shell 32, so that no relative movement exists between the medicine tube 21 and the outer shell 32. The piston rod 22 of the injection head 2 may be fixedly mounted to the first inner push rod 33 described above or to other components fixedly connected to the first inner push rod 33. For example, as shown in fig. 3, the proximal end of the piston rod 22 may comprise a resilient catch 221 extending proximally in the axial direction X, which catch 221 may be secured to a first annular member 5221 shown in fig. 13 (the proximal end of which is secured to a first inner push rod 33, which will be described in detail below), the piston rod 22 remaining secured to each other and thus to the first inner push rod 33 throughout operation after the secured mounting, the piston rod 22 being moved in the axial direction by the first inner push rod 33.

The operation process after the installation of the syringe according to the present invention mainly includes the steps of pressurized energy storage, drug inhalation, air discharge, and injection.

First, in the pressurized energy storage step, initially, the actuation spring 39 located between the outer housing 32 and the rear housing 31 on the syringe proximal side is in an extended state such that the outer housing 32 is located in a distal position relative to the rear housing 31. At the beginning of the pressurized energy storage, the operator rotates the outer housing 32 to move proximally relative to the rear housing 31 (via a threaded engagement therebetween), during which the distal portion of the outer housing 32 can apply a force to the distal portion (e.g., distal flange 33 a) of the first inner push rod 33, thereby simultaneously moving the first inner push rod 33 and the second inner push rod 34 in a proximal direction. When the outer housing 32 is screwed with respect to the rear housing 31, a locking member (not shown) located on the proximal side of the second inner push rod 34 and the locking mechanism 35 are locked to each other, thereby locking the first and second inner push rods 33, 34 to the rear housing 31. During this process, the actuation spring 39 is compressed and stored in preparation for the final injection step.

The pressurized energy storage step is followed by a drug inhalation step. During the inhalation step, the operator rotates the outer housing 32 so that it moves distally relative to the rear housing 31 (still through a threaded engagement therebetween), while the first and second inner push rods 33, 34 remain fixed relative to the rear housing 31 due to being locked by the locking mechanism 35, i.e., during which the outer housing 32 moves distally relative to the first and second inner push rods 33, 34. Since the cartridge 21 is fixed relative to the outer housing 32 and the reservoir 4 and the piston rod 22 are fixed relative to the first inner push rod 33, the cartridge 21 is moved distally relative to the reservoir 4, the piston rod 22. Further, since the injection micro-hole at the distal end of the cartridge 21 is closed by the cap portion 23 (e.g., a packing for sealing the injection micro-hole when the cap portion 23 is provided therein) when the cartridge 21 is closed on the cartridge 21, when the cartridge 21 is moved distally with respect to the piston rod 22, a distal portion of the inner cavity of the cartridge 21 (i.e., a cavity between the distal end of the piston rod and the distal end of the cartridge) forms a receiving cavity, the pressure in the receiving cavity is small, and thus the liquid in the storage container 4 can be sucked into the receiving cavity 215 through the needle 24 received in the liquid medicine passage in the piston rod 22, thereby completing the inhalation.

The drug inhalation step is followed by an air discharge step, which is an injection preparation step, for discharging the gas possibly mixed in the drug tube 21 before injection. In this step, cap 23 is first removed, exposing the injection micropores of the distal end of cartridge 21. The outer housing 32 is then rotated slightly rearward relative to the rear housing 31, and during this process the first inner push rod 33 and the piston rod 22 remain fixed relative to the rear housing 31, since the locking mechanism 35 is still in the locked state. In this way, the cartridge 21 (fixed relative to the outer housing 32) is in fact slightly moved proximally relative to the piston rod 22 (fixed relative to the first inner push rod 33), the piston rod 22 slightly compressing the containing chamber inside the cartridge 21, the gas inside the containing chamber being able to be expelled under pressure from the injection micro-holes.

Finally, the injection step. In this step, the outer housing 32 and the cartridge 21 are fixed relative to the rear housing 31, and the operator operates the locking mechanism 35 (e.g., presses the button 351 at the proximal end of the syringe) to release the locking state with the locking member (not shown) located on the proximal side of the first and second inner push rods, allowing the second inner push rod 34, the first inner push rod 33, the reservoir container 4 and the piston rod 22 to rapidly move distally relative to the rear housing 31 under the rebound of the actuation spring 39, thereby completing the injection by rapidly pressing the liquid medicine in the accommodating chamber in the cartridge 21 by the piston rod 22.

Holding device

With the syringe as described above, after the injection step is completed, the operator can disassemble the components of the syringe for storage.

In general, the built-in storage container 4 as described above can only be mounted into the syringe body 3 or removed from the syringe body 3 together with the injection head 2 including the medicine tube 21 and the piston rod 22, and the storage container 4 cannot be detached alone. When the storage container needs to be replaced, an operator is difficult to flexibly take and put the medicine storage bottle independently, so that a plurality of inconveniences such as difficult medicine replacement are caused.

In order to at least partially solve the above-mentioned problems, the present invention provides a holding device 5 that facilitates the replacement of the above-mentioned storage container 4. The retaining device is configured to be switchable between a locked state in which the retaining device is capable of preventing the storage container from being mounted to or removed from the syringe body of the syringe and an unlocked state in which the retaining device is capable of allowing the storage container to be mounted to or removed from the syringe body. The holding device 5 according to the invention is described in detail below.

It should be noted first that, referring to fig. 5 to 6, during the mounting and dismounting of the storage container 4, which will be discussed later, the injection head 2 is not mounted on the syringe body 3, so that the mounting and dismounting of the storage container 4 is not hindered. For example, in the assembly step, the operator first switches the holding device 5 to the unlocked state, then inserts the storage container 4 into the first inner push rod 33 inside the outer housing 32 in the proximal direction via the distal opening of the outer housing 32 and the distal opening of the first inner push rod 33 described above, and then installs the injection head 2. In the removal step, the operator first removes the injection head 2 from the syringe body 3 so as to no longer block the distal opening of the outer housing 32 and the distal opening of the first inner push rod 33, and thereafter switches the holding device 5 to the unlocked state, and removes the storage container 4 from the first inner push rod 33 within the outer housing 32 in the distal direction via the distal opening of the outer housing 32 and the distal opening of the first inner push rod 33 described above.

Next, the holding device 5 is described in detail with reference to fig. 7 to 14. The holding device includes an operable member 51 operable by an operator to move between a locked position and an unlocked position of the operable member to switch the holding device between the locked state and the unlocked state, and a linkage mechanism 52 configured to switch between the first state and the second state in response to movement of the operable member 51 between the locked position and the unlocked position. When the operable member 51 is in the locked position, the linkage mechanism 52 is in a first state in which the linkage mechanism 52 is capable of preventing the storage container 4 from being mounted to or removed from the syringe body 3 (e.g., the linkage member may positionally interfere with the storage container 4 in a radial direction to prevent axial movement of the storage container 4. This will be discussed in detail below), and wherein when the operable member 51 is in the unlocked position, the linkage mechanism 52 is in a second state in which the linkage mechanism 52 allows the storage container 4 to be mounted to or removed from the syringe body 3. In this embodiment, the linkage is held by a first internal pushrod 33 within the outer housing 32.

Referring to fig. 8 to 10, in the present embodiment, the operable member is disposed on the outer housing 32, and is preferably configured as a push-type operable member. The operable member 51 can be mounted in a recess 321 opened on a circumferential side wall of the outer housing 32 of the syringe body 3, and the operable member 51 can move in the recess 321 between a locked position and an unlocked position with respect to the outer housing along the axial direction X.

In the present embodiment, the locked position of the operable member 51 is located distally of the unlocked position. The operable member 51 includes a base 511, an operator engagement portion 512, a slide portion 513, and a projection 514. The base 511 extends in the axial direction X, which is substantially plate-shaped, providing a setting foundation for other parts and structures of the operable member 51. The operator engaging portion 512 extends from the radially outer surface of the base portion 511 toward the outside in the radial direction, and is configured to be able to protrude from the outer housing 32 toward the outside frequently so as to be able to be engaged by an operator to operate the operable member 51 to move between the locked position and the unlocked position. The operator interface 512 may be a variety of buttons, such as toggle buttons, push buttons, etc., as would occur to those of skill in the art. The sliding portion 513 extends inward in the radial direction from the radially inner surface of the base portion 511, and the radially inner surface of the sliding portion is capable of contacting and substantially conforming to the radially outer surface of the bottom wall 3211 of the recess 321 of the outer housing 32 to move on the surface in the axial direction X. The protruding portion 514 extends inward in the radial direction from the radially inner surface of the sliding portion 513, and protrudes toward the radially inner side of the outer housing 32 from the opening 32111 of the bottom wall 3211 of the recess 321 at the corresponding position. The opening 32111 extends in the axial direction X and allows the protrusion to move back and forth therein in the axial direction X, and wherein the protrusion 514 protruding radially inward from the opening is capable of engaging the linkage 52 located inside the outer housing 32 such that the linkage switches between the first state described above (when the protrusion is in the distal position, the linkage locks the storage container 4) and the second state (when the protrusion is in the proximal position, the linkage unlocks the storage container 4) in response to movement of the protrusion 514 in the axial direction X in the opening 32111 of the recess 321.

Further, in order to keep the operable member 51 in a locked state in a state not operated by the operator, a corresponding biasing mechanism is also provided for the operable member 51. Specifically, the sliding portion 513 of the operable member includes a columnar member 5131 extending in the axial direction X, and an end wall of the recess perpendicular to the axial direction X is provided with a hole 32121 aligned with the columnar member 5131 (i.e., the columnar member 5131 and the hole 32121 are aligned in the circumferential direction with their axes aligned or substantially aligned with each other), the columnar member 5131 extending proximally from a proximal end surface of the sliding portion 513, and the hole 32131 being provided in a proximal end wall 3212 of the recess 321. A first spring 53 extending in the axial direction X is provided between the columnar member 5131 and the hole 32121, and includes a first end 531 accommodated and restrained in the hole 32121 of the end wall 3212 of the recess, and a second end 532 fitted around the outer peripheral side of the columnar member 5131. The first spring 53 can bias the operable member 51 toward the lock position by the columnar member 5131. When the operator desires to unlock the retaining device, the operator interface 512 may be pushed or toggled to move the operable member 51 in a proximal direction to the unlocked position, wherein the cylindrical member 5131 compresses the first spring 53 proximally.

Further, in order to facilitate movement of the operable member 51 in the axial direction, ensuring that it does not shift, guiding means are also provided. The guiding means comprises a first guiding engagement portion extending in the axial direction X provided in the recess 321 of the outer housing 32 and a corresponding second guiding engagement portion extending in the axial direction X provided in the sliding portion 513 of the operable member. The first and second guide engagement portions are configured to cooperate with each other to guide movement of the slide portion 513 of the operable member in the recess 321 of the outer housing.

In the present embodiment, the first guide engagement portion is a guide post 322 fixedly provided in a recess 321 of the outer housing and extending in the axial direction X, and the second guide engagement portion is a through-hole 5132 opened in the sliding portion and extending in the axial direction X, each through-hole 5132 being shape-fitted and position-corresponding to the corresponding guide post 322, so as to allow the sliding portion 513 to move in the axial direction X by axial movement of each through-hole on the corresponding guide post. It is conceivable that the guide means is not limited to the form of the guide post and the through hole provided in the present embodiment, and those skilled in the art may adopt other structures as needed as long as they can perform a guiding function of the axial movement of the operable member 51 with respect to the recess 321. In addition, in the embodiment shown in fig. 8 to 10, two through holes 5132 are provided, which are respectively opened at positions near both end portions of the sliding portion parallel to the axial direction X, on both sides of the guide post 322. Correspondingly, two guide posts are also arranged and are respectively positioned on the concave part and correspond to the circumferential positions of the two through holes of the sliding part. The position and number of the guide posts and the through holes can be adjusted according to actual needs by a person skilled in the art.

To fix the guide posts 322 to the recess 321, both ends of each guide post in the axial direction X are respectively received and fixed in two U-shaped fixing pieces 323 extending outward in the radial direction from the radially outer surface of the bottom wall 3211 of the recess 321, the two U-shaped fixing pieces being configured to restrict movement of the guide post in common, that is, to prevent movement of the guide post in the axial direction and the circumferential direction.

Further, referring to fig. 5 and 7, the first inner push rod 33 includes a first hollowed-out portion 331 formed on a circumferential side wall, and the outer housing 32 includes a second hollowed-out portion 322 aligned with the first hollowed-out portion in a circumferential direction of the syringe, the first hollowed-out portion 331 and the second hollowed-out portion 322 together forming a visual window for an operator to observe the storage container 4. The first hollowed-out portion 331 and the second hollowed-out portion 322 each have an elongated shape extending along the axial direction X, and the second hollowed-out portion is located near the recess 321. The syringe 1 further comprises a cover 6 engageable with the outer housing 32 of the syringe body 3 to cover the recess 321 and the second hollowed-out portion 322. The cover 6 includes a window 61 through which the operator engaging portion 512 of the operable member 51 can protrude from the outer housing 32 when the cover is closed onto the outer housing 32, thereby being exposed to the operator to be operable by the operator.

Fig. 11-14 illustrate a linkage 52 according to a preferred embodiment of the present invention. Referring to fig. 11, the linkage 52 includes a limit mechanism 521 and a blocking mechanism 522. The stopper mechanism is configured to be movable in the axial direction X between the first position and the second position in response to the movement of the protruding portion 514 of the above-described operable member 51 in the opening 32111 of the recess 321 of the outer case in the axial direction X. In this embodiment, the first position is distal relative to the second position, that is, when the operable member 51 is in the distal locked position, the projection 514 is in the distal position, with the stop mechanism 521 of the linkage 52 in the distal first position, the stop mechanism 521 in the first position maintaining the blocking mechanism 522 in the blocking state such that the blocking mechanism 522 is able to interfere with the storage container 4 in a radial direction to prevent the storage container from being mounted to or removed from the syringe body, and when the operable member 51 is operated to the proximal unlocked position, the projection 514 is in the proximal position, with the stop mechanism 521 of the linkage 52 being pushed by the projection 514 to the proximal second position, the stop mechanism 521 in the second position switching the blocking mechanism 522 to the non-blocking state such that the blocking mechanism 522 no longer interferes with the storage container 4 to allow the storage container to be mounted to or removed from the syringe body.

Referring to fig. 12 to 13, the blocking mechanism 522 includes a first annular member 5221 including a blocking portion 52211 which is open with a through hole 52212 extending in a radial direction, in which a ball 5222 is accommodated. The diameter of the through hole 52212 is not smaller than the ball to allow the ball 5222 to move back and forth in the radial direction along the inner wall surface of the through hole. As shown in fig. 13 (to clearly show the structure of the through hole, the ball in the through hole is not shown), the through hole 52212 includes a first open end 522121 located radially inward, a second open end 522122 located radially outward, and an annular first flange 522123 extending inward of the through hole from the inner wall surface of the through hole at the first open end, the first flange being sized to allow at least a portion of the ball 5222 to protrude radially inward from the first open end 522121 of the through hole 52212 to an extent that interferes with the radial position of the storage container 4 while preventing the ball from continuing to move radially inward out of the through hole from the first open end 522121.

Preferably, the first annular member 5221 includes a plurality of circumferentially distributed through holes 52212, each of which accommodates a ball 5222 therein. More preferably, the plurality of through holes 52212 are arranged at equal intervals.

Further, the first annular member 5221 also includes an engagement portion 52214 distal of the blocking portion 52211 of the first annular member for engaging the proximal end of the piston rod 22 to secure the piston rod to one another. Preferably, the engagement portion 52214 of the first annular member is formed with a third annular groove 52213 near the distal end of the first annular member, and wherein the proximal end of the piston rod is provided with a resilient catch 221 extending proximally in the axial direction X (as shown in fig. 3), the catch 221 being capable of being snapped to the distal end face 522131 of the third annular groove (as shown in fig. 13 and 15B) such that the piston rod 22 and the first annular member 5221 are fixed to each other.

Further, the proximal end of the first annular member 5221 is configured to be secured to the distal end of the first inner push rod 33 described above. For example, the proximal end of the first annular member 5221 is formed with external threads and the distal end of the first inner push rod 33 is formed with internal threads that interfit with the external threads of the first annular member 5221, thereby enabling the two to be threadably secured to one another.

Referring to fig. 14, the stopper mechanism 521 includes a second annular member 5211 sleeved on the outer peripheral side of the first annular member 5221, which is configured to be movable in the axial direction X between a distal first position and a proximal second position in response to movement of the projection 514 in the axial direction X in the opening 32111 of the recess 321 of the outer casing. The second annular member 5211 includes an annular second flange 52111 extending radially inward from an inner wall surface of the second annular member.

When the second annular member 5211 is in the distal first position (when the operable member 51 is biased in the distal locked position by the first spring 53 with the projection 514 in the distal position), the second flange 52111 is aligned with the through-hole 52212 of the blocking mechanism 522 in the axial direction X, when the radially inner side surface of the second flange 52111 abuts the ball 5222 in the through-hole 52212 of the blocking mechanism to force at least a portion of the ball to protrude radially inward from the first open end 522121 of the through-hole to interfere with each other in the radial direction with the storage container 4. When the second annular member 5211 is in the second position (at which time the operator pushes the operator engaging portion 512 proximally such that the cylindrical member 5131 of the sliding portion 513 compresses the first spring 53 proximally against the biasing force of the first spring to switch the operable member to the unlocked position, the protrusion 514 is in the proximal position), the second flange 52111 is displaced in the axial direction X from the through-hole 52212 of the blocking mechanism to allow the ball 5222 to move freely radially outward to a position no longer protruding radially inward from the first open end 522121 of the through-hole so as to no longer interfere with or block the storage container 4, whereby the storage container 4 can be freely installed or removed.

Further, the stopper mechanism 521 further includes a second spring 5212 (shown in fig. 12) that is positioned between the first annular member 5221 and the second annular member 5211 and that is sleeved on the outer peripheral side of the first annular member 5221. The proximal end of the second spring 5212 abuts the distal end surface of the first inner push rod 33 and the distal end of the second spring abuts the proximal surface of the second flange 52111 of the second annular component 5211. The second spring 5212 is configured to bias the second annular member distally toward the above-described first position by the proximal end surface of the second flange 52111.

The distal side of the second flange 52111 of the second annular member 5211 is formed with a slope 521111 (as shown in fig. 16A), wherein, in the course of the operator pushing the operable member 51 proximally so that the second annular member 5211 of the stopper mechanism 521 of the linkage 52 moves proximally in the axial direction X from the above-described first position to the above-described second position, the ball 5222 can move along the slope 521111 of the second flange 52111 to a position no longer protruding radially inward from the first open end of the through hole (no longer blocking the storage container 4).

The second annular member 5211 further includes a third flange 52112 located at a distal portion of the second annular member 5211 extending radially inward from an inner wall of the second annular member, the third flange being capable of sliding on an outer peripheral surface of the distal portion of the first annular member 5221 during movement of the second annular member 5211 in the axial direction. The second flange 52111 is proximal to the third flange 52112 and the second flange is between the third flanges forming a first annular groove 52113 configured to at least partially receive the ball 5222 when the second annular member 5211 is in the second position.

For a better explanation of the construction and principle of the holding device, reference is next made to fig. 15A-15B and fig. 16A-16B, wherein fig. 16A-16B are partial enlarged views of the holding device 5 of fig. 15A-15B, respectively. In these figures, the storage container 4 is shown in the first internal push rod, so the following process of unlocking the holding means is described taking the example of removal of the storage container 4 from the syringe body 3. Of course, it will be understood by those skilled in the art that the unlocking process when the storage container 4 is mounted to the syringe body 3 is the same or similar, and will not be described in detail herein.

Fig. 15A and 16A show the holding device 5 in the locked state. At this time, the operable member 51 is biased at the distal lock position by the first spring 53, the link mechanism 52 is in a first state in which the removal of the storage container 4 is prevented, in which the second annular member 5211 in the stopper mechanism 521 of the link mechanism is biased at the distal first position by the second spring 5212, at which time the radially inner side surface of the second flange 52111 of the second annular member 5211 abuts against the ball 5222 in the through hole 52212 of the stopper mechanism, forcing at least a part of the ball to protrude radially inward from the first opening end 522121 of the through hole so as to interfere with each other in the radial direction with the storage container 4 (in this embodiment, the holding means is provided at the distal portion of the syringe main body, and thus the ball 5222 blocks the distal portion of the storage container 4), preventing the storage container 4 from being removed from the distal opening of the first inner push rod 3.

Fig. 15B and 16B show the holding device 5 in the unlocked state. At this point, the operator applies a force to the operator interface 512 such that the operable member moves proximally to the unlocked position against the distally biasing force of the first spring 53. In this way, the link mechanism 52 is switched to the second state in which the removal of the storage container 4 is no longer prevented, in which the second annular member 5211 in the stopper mechanism 521 of the link mechanism is moved proximally to the second position against the biasing force of the second spring 5212 distally by the urging of the projection 514 of the operable member, at which time the second flange 52111 of the second annular member 5211 is offset from the through-hole 52212 of the stopper mechanism in the axial direction X to allow the ball 5222 to move freely radially outward to a position in which it no longer protrudes radially inward from the first open end 522121 of the through-hole, so as not to interfere with or block the storage container 4, whereby the storage container 4 can be removed freely.

In the embodiment described above, when the locked position of the operable member 51 and the stopper member 521 is located distally of the unlocked position, the present invention is not intended to limit the relative orientation between the unlocked position and the locked position. For example, in actual use, the retention means may also be adjusted as required by a person skilled in the art such that the locked position is located proximally of the unlocked position. For example, the above-described first spring 53 may be replaced with a spring capable of holding the operable member 51 in a proximal position (biased toward the proximal position) by the columnar member 5131 (e.g., replaced with a compression spring by an extension spring), or the first spring 53, the columnar member 5131 may be disposed in a distal portion of the sliding portion 513 and the hole 32131 may be disposed in a distal end wall of the recess 321 accordingly. Further, similarly, the second spring 5212 may also be replaced with a spring capable of holding the second annular member 5211 in a proximal position (biased toward the proximal position) (e.g., replaced with a compression spring by an extension spring and secured with a corresponding structure of the proximal end of the second annular member 5211), or the second spring 5212 may be disposed distally of the second annular member 5211 with the proximal end abutting a distal portion of the second annular member secured to other components inside an outer housing secured relative to the first inner push rod, thereby biasing the second annular member to the proximal position.

Further, in order to make it more convenient for the operator to remove the storage container from the syringe body 3, a structure for pushing out the storage container is also provided. Referring to fig. 15A-15B and 17-19, the holding device preferably further includes a base 36 positioned at the proximal end of the storage container and configured to form-fit with the proximal end of the storage container for receiving and holding the proximal end of the storage container. A third spring 37 is also provided between the base 36 and the second inner push rod 34. As described above, the second internal push rod 34 is configured to be located proximal to the first internal push rod 33 and fixed to each other with the first internal push rod 33 (e.g., by internal threads of the distal end of the second internal push rod and internal threads of the proximal end of the first internal push rod). The third spring 37 is configured to bias the seat 36 distally in the axial direction X.

Specifically, referring to FIG. 17, in a preferred embodiment, the second inner pushrod 34 includes a first axial extension 341 including an elongated first through slot 3411 opening in the sidewall extending in the axial direction X, the first through slot extending to the distal end of the first axial extension 341, and a second axial extension 342 extending distally from the distal end of the first axial extension 341. The first axially extending portion 341 is provided with an annular fourth flange 3412 extending radially inward from the inner wall surface of the first axially extending portion at a substantially intermediate position in the axial direction X. The second axial extension 342 is used to engage the proximal end of the first inner push rod 33 (provided with the internal threads described above) to secure the first inner push rod 33 to each other.

In matching with the structure of the second inner push rod 34 described above, referring to fig. 18 to 19, the base 36 includes a third axial extension 361, a distal portion of which is provided with a distally extending tab 3611, which corresponds in position to the first through slot 3411 of the second inner push rod 34 so as to be movable in the axial direction X within the first through slot, and a fourth axial extension 362 extending distally from a distal end of the third axial extension 361. Preferably, the first axial extension of the second inner push rod 34 comprises a plurality of first through slots 3411 uniformly distributed in the circumferential direction, and correspondingly, the third axial extension of the base comprises a plurality of tabs 3611 corresponding in position to the first through slots and in the same number. The present embodiment can minimize the diameter of the second inner push rod and the length in the axial direction by providing the through groove by removing a part of the material on the side wall of the second inner push rod 34, thereby reducing the overall size of the syringe body while saving the material.

In addition to the mating configuration of channel 3411 and tab 3611 described above, other mating arrangements may be used to guide the axial movement of base 36 within second inner pushrod 34. For example, the plurality of tabs 3611 may be modified to a ring-shaped boss portion extending uninterrupted in the circumferential direction, and accordingly, a ring of steps (for example, at the axial position of the proximal end of the through groove 3411 of fig. 17) needs to be provided in the first axially extending portion 341 of the second inner push rod 34. In order to provide this additional step, the first axial extension 341 of the second inner push rod 34 needs to be correspondingly thickened or lengthened to provide a step providing space.

The proximal end of the third spring 37 abuts the distal surface of the fourth flange 3412 of the second inner push rod 34 and the distal end of the third spring abuts an inner step surface 364 (shown in fig. 19) of the connection region between the third axial extension 361 and the fourth axial extension 362 of the base, whereby the base 36 can be biased distally in the axial direction X by the inner step surface. The reservoir 4 comprises a distally located drug storage region 41 and an annular engagement region 42 extending proximally from a proximal end of the drug storage region (see fig. 15A), the engagement region 42 being held between the tab of the third axial extension 361 and the fourth axial extension 362 of the chassis, and the proximal end of the engagement region 42 abutting an outer stepped surface 363 of the connection region between the third axial extension and the fourth axial extension of the chassis. When the operator operates the operable member 51 to unlock the holding device 5, the reservoir 4 is no longer radially constrained by the blocking mechanism described above, at which time the base 36 is pushed out of the syringe body 3 together with the reservoir 4 via the first inner push rod 33 and the distal opening of the outer housing 32 under the distally directed biasing force of the third spring 37. The arrangement of the base and the third spring is such that the storage container can be pushed out (ejected) of the syringe body directly after unlocking the holding means 5 when it is desired to remove the storage container, without the need for an operator to manually pull or pour the storage container out of the syringe body or using an auxiliary implement.

Further preferably, in order to avoid shaking (e.g., displacement in an axial, radial or circumferential direction) of the storage container 4 in the first inner push rod 33 during operation, preventing occurrence of such a situation that the storage container 4 of, for example, glass material is knocked and cracked by the side wall of the first inner push rod 33, the inner wall surface of the proximal end portion of the first inner push rod 33 is provided with a second annular groove 332 in which a rubber ring 38 contacting the outer circumferential side surface of the storage container is accommodated, the rubber ring being used for preventing movement of the storage container.

Turning next to fig. 20-22, a retaining device according to another preferred embodiment of the present invention is shown. In this embodiment, the overall structure and arrangement of the syringe may be the same as or similar to those described in the foregoing embodiment, and will not be described in detail herein, only with respect to the differences from the holding device of the foregoing embodiment.

In the present embodiment, similarly to the foregoing embodiment, the operable member operable by the operator to switch the holding device between the locked state and the unlocked state is arranged on the outer housing 32, the linkage mechanism is held by the tubular first inner push rod 33 in the outer housing of the syringe main body, and the storage container 4 can be accommodated in the lumen of the first inner push rod 33.

Referring to fig. 20, the link mechanism includes a swing link 71 and an elastic member 72 which are accommodated inside and held by the first inner push rod 33. A through groove (in this embodiment, a third through groove 334) for accommodating and holding the swing link and the elastic member is provided in a position near the distal end of the circumferential side wall of the first inner push rod 33. Referring to fig. 21, a swing link 71 is pivotally mounted to the third through slot 334. Specifically, the swing link 71 includes a pin 714 provided at a substantially middle position of the swing link, and the swing link 71 is mounted to the third through-slot 334 through the pin 714. The third through-groove 334 includes opposite side walls extending in the axial direction X, each of which has a mounting hole 3341 (refer to fig. 22) formed therein for receiving and fixing an end of a pin rod about which the swing link 71 can pivot in the third through-groove 334.

With continued reference to fig. 21, the swing link 71 includes a first leg 711 proximal of the pin 714 and a second leg 712 distal of the pin 714. The second leg 712 is capable of interfering with the storage container 4 from a radial direction (e.g., when the storage container is installed in the first internal push rod and the retaining device is in the locked state), in response to the operable member (in this embodiment, the operable member is configured to be depressed by an operator to move from the locked position toward the unlocked position), the second leg 712 is capable of interfering with and blocking the obliquely extending shoulder between the distal portion of the body of the storage container 4 and the head of the storage container 4, thereby preventing the storage container from being removed in the distal direction), to a second state that does not interfere with the storage container 4, thereby allowing the storage container 4 to be installed into or removed from the internal lumen of the first internal push rod. Further, the second leg portion 712 of the swing link 71 includes a projection 713 extending in the radially inward direction from a radially inner surface of the second leg portion, the projection being configured to be capable of radially interfering with the storage container 4 when the second leg portion 712 of the swing link 71 is in the above-described first state, and to be capable of not interfering with the storage container 4 when the second leg portion 712 is in the second state.

Further, the elastic member 72 is configured to bias the second leg 712 of the swing link 71 toward the first state radially interfering with the storage container 4. That is, the resilient element can bias the second leg 712 in a radially inward direction such that the protrusion 713 can radially interfere with the storage container (e.g., when the storage container is properly installed in the first inner push rod and the second leg 712 is in the first state, the protrusion 713 radially interferes with and blocks the distal portion of the storage container) such that the storage container cannot be installed or removed.

Further, referring to fig. 22, the third channel 334 of the first inner push rod 33 includes a first portion 3342 located proximally and a second portion 3343 located distally having a smaller width than the first portion 3342. The first portion 3342 is set to have a smaller width than the second portion 3343 in order to arrange the elastic member 72 radially inside the circumferential side wall of the first inner push rod 33 at the second portion 3343. Specifically, the elastic member 72 is disposed between and abuts the radially outer side surface of the second leg 712 of the swing link 71 and the radially inner side surface of the circumferential side wall of the first inner push rod 33 at the second portion 3343 of the third through groove 334. The resilient element 72 is preferably an extension spring (other types of resilient elements 72 may be chosen by a person skilled in the art as the actual need arises, e.g. a compressible resilient post or the like) capable of biasing the second leg 712 towards a radially inner direction via the radially outer surface of the second leg 712 against which it abuts, such that the protrusion 713 of the second leg 712 radially interferes with the storage container 4.

Preferably, in the present embodiment, the first leg 711 and the second leg 712 extend substantially parallel to each other.

Further, the operable member is capable of engaging the first leg 711 of the swing link 71 to allow the first leg 711 of the swing link 71 to move in a radially inward direction (in a proximal arrow direction as shown in fig. 21) when the operator presses the operable member, so that the swing link 71 pivots about the pin (at this time, the second leg 712 moves in a distal arrow direction as shown in fig. 21 against the biasing force of the elastic member 72) to a position where the protruding portion 713 of the second leg 712 thereof does not interfere with the storage container 4.

Preferably, to limit the pivoting range of the swing link 71, the second leg 712 is prevented from being excessively biased by the elastic member 72, and a bottom wall 3344 is formed in the second portion 3343 of the third through-slot 334 of the first inner push rod 33, the bottom wall being configured such that the distal end of the second leg 712 can overlap on the bottom wall 3344 when the second leg 712 of the swing link 71 is in the first state (the holding means is in the locked state), preventing the second leg 712 from moving further radially inward. Meanwhile, in order to prevent the bottom wall from obstructing the protrusion 713, the distance the bottom wall 3344 extends proximally is set such that the bottom wall 3344 does not contact the protrusion 713 of the swing link 71 at all times in the range of movement of the swing link.

The present invention is not intended to limit the number of the third through grooves, the swing rods, and the elastic elements, and one skilled in the art may provide one third through groove, or may separately provide a plurality of third through grooves (for example, two third through grooves are symmetrically arranged) on the circumferential side wall of the first inner push rod according to need, and each through groove accommodates and holds the corresponding swing rod and elastic element.

Turning next to fig. 23-25, a retaining device according to another preferred embodiment of the present invention is shown. This embodiment is a modification of the embodiment described with reference to fig. 20 to 22. The overall structure and arrangement of the syringe may be the same as or similar to those described in the foregoing embodiments, and will not be described again, but only with respect to the differences from the holding device of the foregoing embodiments.

In the present embodiment, similarly to the embodiment described with reference to fig. 20 to 22, the operable member operable by the operator to switch the holding device between the locked state and the unlocked state is arranged on the outer housing 32, the link mechanism is held by the tubular first inner push rod 33 in the outer housing of the syringe main body, and the storage container 4 can be accommodated in the lumen of the first inner push rod 33.

Referring to fig. 23 and 24, the link mechanism includes a swing link 71 'and an elastic member 72' which are accommodated inside and held by the first inner push rod 33. A through groove (in this embodiment, a fourth through groove 335) for accommodating and holding the swing link 71 'and the elastic member 72' is opened at a position near the distal end of the circumferential side wall of the first inner push rod 33. Referring to fig. 24, a swing link 71' is pivotally mounted to the fourth slot 335. Specifically, the swing link 71 'includes a pin 714' provided at a substantially middle position of the swing link, and the swing link 71 'is mounted to the fourth slot 335 through the pin 714'. The fourth slot 335 includes opposite side walls extending in the axial direction X, each side wall having a mounting hole 3351 (refer to fig. 25) formed therein for receiving and fixing an end of the pin 714', about which the swing link 71' can pivot in the fourth slot 335.

In this embodiment, unlike the previous embodiment, the first leg 711' (rather than the distal second leg) of the swing link 71' is capable of being moved from a radially interfering with the storage container 4 (e.g., when the storage container is installed in the first internal push rod and the retaining device is in the locked state) in response to the operable member (in this embodiment, the operable member is configured to be depressed by an operator to move from the locked position toward the unlocked position, the first leg 711' is capable of interfering with and blocking the obliquely extending shoulder between the distal portion of the body of the storage container 4 and the head of the storage container 4, thereby preventing the storage container from being removed in the distal direction) to a second state that does not interfere with the storage container 4, thereby allowing the storage container 4 to be installed into or removed from the internal lumen of the first internal push rod. Specifically, the proximal end of the first leg 711 'of the swing link 71' is configured to radially interfere with the storage container 4 when the first leg 711 'of the swing link 71' is in the first state and to not interfere with the distal portion of the storage container 4 when the first leg is in the second state.

Further, the resilient element 72' is configured to bias the second leg 712' of the swing link 71' in a radially outward direction, such that the swing link 71' pivots about the pin at a position where the proximal end of the first leg 711' can radially interfere with the storage container 4. That is, the resilient element is able to bias the second leg 712 'in a radially outward direction such that the first leg 711' on the other side of the pin extends further radially inward relative to the unlocked state, such that the proximal end is able to contact and interfere with the radially inward storage container 4.

Preferably, in the present embodiment, in order to facilitate the proximal end of the first leg 711' to contact and interfere with the storage container in the locked state of the holding means, an obtuse angle is formed between the first leg 711' and the second leg 712' in the radially inward direction.

Further, referring to fig. 25, the fourth slot 335 of the first inner push rod includes a proximal first portion 3352 and a distal second portion 3353. The first portion 3352 allows the first leg 711 'of the swing link 71' to pass therethrough and radially interfere with the storage container 4. The second portion 3353 is provided with a bottom wall 3354, between the radially outer surface of which the elastic element 72' is held and the radially inner surface of the second leg 712' of the oscillating bar 71', against which the two surfaces abut. The resilient element is preferably an extension spring (other types of resilient elements 72 'may be selected as desired by those skilled in the art, such as a compressible resilient post or the like) capable of biasing the second leg 712' in a radially outward direction via the radially inner surface of the second leg 712 'against which it abuts to retain the first leg 711' in a position in which its proximal end radially interferes with the storage container 4.

Further, the operable member is capable of engaging the second leg 712 'of the swing link 71' to allow the second leg 712 'of the swing link 71' to move in a radially inward direction (in the distal arrow direction as shown in fig. 24) against the biasing force of the resilient element 72 'when the operator presses the operable member, such that the swing link 71' pivots about the pin (at this time, the first leg 711 'moves in the proximal arrow direction as shown in fig. 24) to a position where the proximal end of the first leg 711' does not interfere with the storage container 4.

Furthermore, the present invention is not intended to limit the number of the third through groove, the fourth through groove, the swing link, the elastic element in the above-described embodiments. One skilled in the art may provide one third through slot, or a plurality of third through slots may be separately provided on the circumferential side wall of the first inner push rod as needed (for example, two third through slots are symmetrically arranged), and each through slot accommodates and holds a corresponding swing link and elastic element. Similarly, one skilled in the art may provide one fourth slot, or a plurality of fourth slots (e.g., two fourth slots symmetrically arranged) may be provided separately in the circumferential side wall of the first inner push rod as desired, each of which accommodates and retains a corresponding swing link and elastic member.

It will be appreciated that the features of the two embodiments described with respect to fig. 23-25 and 20-22 may be used interchangeably or in combination and the present invention is not intended to be limited thereto. For example, a protrusion similar to the protrusion 713 of the swing lever shown in fig. 21 may be provided at the first leg 711 'of the swing lever shown in fig. 24 so as to interfere with the storage container by the protrusion instead of the proximal end of the first leg 711'. Similarly, the projection 713 may also be omitted in the swing link 71 shown in fig. 21, while the storage container is interfered with by the distal end of the second leg 712. Furthermore, in both embodiments, the first leg and the second leg may be arranged to extend parallel to each other or form an obtuse angle therebetween towards the radially inner direction, which may be chosen by a person skilled in the art as desired.

Turning next to fig. 26-29, a retaining device according to another preferred embodiment of the present invention is shown. In this embodiment, the overall structure and arrangement of the syringe may be the same as or similar to those described in the foregoing embodiment, and will not be described in detail herein, only with respect to the differences from the holding device of the foregoing embodiment.

The holding device according to the present embodiment also includes an operable member and a linkage 82. The linkage mechanism includes a limit mechanism configured to move in an axial direction (X) between a first position and a second position in response to movement of the operable member in the axial direction (X) between the locked position and the unlocked position, and a blocking mechanism configured to switch between a blocking state and a non-blocking state in response to movement of the limit mechanism between the first position and the second position. When the stopper mechanism is in the first position, the blocking mechanism is in a blocking state, the blocking mechanism in the blocking state being capable of interfering with the storage container in the radial direction to prevent the storage container from being mounted to or removed from the syringe body. When the spacing mechanism is in the second position, the blocking mechanism is in a non-blocking state, the blocking mechanism in the non-blocking state not interfering with the storage container to allow the storage container to be mounted to or removed from the syringe body.

The operable mechanism and linkage mechanism of this embodiment may be disposed proximate to the proximal portion of the storage container. Of course, the arrangement positions of the operable mechanism and the linkage mechanism can also be adjusted according to actual needs by those skilled in the art.

Referring to fig. 28, the stopper mechanism according to the present embodiment includes a slip ring member 821. The slip ring member 821 is arranged in the first inner push rod 33 and is sleeved on the storage container and is movable in the axial direction X relative to the storage container between the first position and the second position in response to movement of the operable member in the axial direction X between the locked position and the unlocked position. The slip ring member 821 includes a distal cylindrical portion 8212, the outer peripheral side wall of which is arranged with a projection 8213 that is capable of engaging the operable member to move in the axial direction in a correspondingly provided groove in the inner wall surface of the first inner push rod 33 under the drive of the operable member to guide the slip ring member 821 to follow the operable member in the axial direction.

Preferably, in the present embodiment, the operable member is disposed on the outer housing 32, and is configured as a push-type operable member. The operable components in this embodiment may be substantially similar to the operable mechanism in the embodiment described with respect to fig. 7-16B, with only some of the necessary adjustments. For example, the protrusion 514 of the operable member 51 in the embodiment described with respect to fig. 7 to 16B may be replaced with an operation lever (not shown) which may extend from the operable member toward the radially inner side into a hole 82131 of the boss 8233 of the cylindrical portion, which hole is engageable with and mutually fixed to each other, so that when the operator operates the operable member, the slip ring member 821 may be moved in the axial direction by the engagement between the operation lever and the hole 82131. Accordingly, the first inner push rod 33 is provided with a second through groove 333 at a position corresponding to the boss, which second through groove 333 allows the hole 82131 of the boss 8233 to be exposed to the operation rod when the slip ring part 821 is moved between the first position and the second position (i.e., the hole 82131 is not covered by the circumferential side wall of the first inner push rod at all positions within the axial movement range of the boss).

Preferably, the cylindrical portion 8232 of the slip ring part comprises two protrusions 8233 symmetrically arranged about the central axis, each protrusion comprising the above mentioned hole 82131. Accordingly, two operable members are provided at the outer peripheral side wall of the outer housing symmetrically about the central axis, each of which is engaged with the hole 82131 of each of the bosses through the operating lever. Correspondingly, the first inner push rod 33 also includes two second through slots 333 symmetrically arranged thereon.

Slip ring component 821 also includes a proximal frustoconical portion 8211 extending proximally from cylindrical portion 8212, frustoconical portion 8211 for engaging blocking mechanism 822 to switch the blocking mechanism between a blocking state and a non-blocking state.

The blocking mechanism 822 is positioned proximally of the stop mechanism and comprises a resilient ring piece member 8221 arranged in the first inner push rod 33 and sleeved over the storage container 4 and engageable with the frustoconical portion 8211 of the distal slip ring member 821 to be switched by the frustoconical portion 8211 between a blocking state and a non-blocking state, and

A mounting member 8222 for fixedly mounting the resilient ring segment member 8231 to the first inner push rod 33, the mounting member comprising a distal tubular element 82221 and a proximal annular stop element 82321. The tubular element 82221 is snapped into a correspondingly disposed securing slot in the first inner pushrod 33 and is capable of secure connection with the elastic loop component 8221. An annular stop element 82821 is disposed proximally of the tubular element 82221 for limiting axial movement of the tubular element (i.e., proximally limiting the tubular element, preventing an operator's unlocking force from causing the tubular element to disengage from the first inner push rod's securing slot and slide proximally).

The elastic ring member 8221 includes a plurality of elastic elements 82211 arranged continuously in the circumferential direction, each elastic element 82211 including a fixing portion 822111 located radially outward for fixing the elastic element to the distal edge of the tubular element 82221, and a deformable portion 822112 capable of being elastically deformed such that an included angle R (shown in fig. 29) between the deformable portion and the fixing portion is switched between a first angle and a second angle.

When the slide ring member 821 of the stopper mechanism is in the first distal position, the truncated conical portion 8211 does not engage the annular member 8221, the deformable portion 822112 of each of the plurality of elastic elements 82311 is in an unstressed state, at which point the angle between the deformable portion 822112 and the fixed portion 822111 is a first angle, and at which point the radially inner end of the deformable portion 822112 is able to contact and interfere with the storage container 4. When the slip ring member 821 of the stopper mechanism moves proximally to the second position, the frustoconical portion 8211 biases the deformable portion of each of the plurality of elastic elements 82211 radially outward such that the angle between the deformable portion 822112 of each of the plurality of elastic elements 82211 and the fixed portion 822111 is converted from a first angle to a second angle by being subjected to pressure, at which time the radially inner end of the deformable portion 822112 no longer contacts the storage container. Wherein, the first contained angle is greater than the second contained angle. That is, when the deformable portion 822112 is partially engaged and urged by the truncated conical portion 8211 of the slip ring member 821, it can be deformed in a direction closer to the fixed portion 822111 (as shown in fig. 29).

As shown in fig. 28, radially inner end portions of the deformable portions 822112 of the plurality of elastic elements 8231 collectively form an opening portion 8232 of the elastic annular member 8231. When the included angle between the deformable portion 822112 and the fixed portion 822111 of each of the plurality of resilient elements 8231 is a first included angle (i.e., the slip ring component 821 of the stop mechanism is in a first, distal position, the frustoconical portion 8211 does not engage the annular component 8221), the opening 82312 has a first diameter. When the included angle between the deformable portion 822112 and the fixed portion 822111 of each of the plurality of elastic elements 82211 is a second included angle (when the slip ring component 821 of the stop mechanism is moved proximally to the second position, the frustoconical portion 8211 biases the deformable portion of each of the plurality of elastic elements 82211 radially outward), the opening 82212 has a second diameter. Wherein the second diameter is greater than the first diameter. That is, when the operator operates the operable member (from the locked position to the unlocked position) such that the above-described operation lever passes through the hole 82131 to bring the slip ring member 821 of the stopper mechanism proximally from the first position to the second position, the truncated conical portion 8211 of the slip ring member 821 presses the deformable portion 822112 of each of the plurality of elastic elements 82211 of the elastic annular member 8221 radially outward, so that the opening 82212 defined by the elastic annular member 8221 becomes large so as not to contact or interfere with the storage container 4 any more, whereby the storage container 4 can be freely mounted or removed.

Further, in the present embodiment, the storage container 4 can also be mounted in the first inner push rod. Referring to fig. 27, the first inner push rod 33 includes a second through slot 333 provided corresponding to the hole 82131 on the boss 8233 of the slip ring part 821, which slot allows the hole 82131 to be exposed from the second through slot 333 when the slip ring part 821 is in both the first and second positions, so that the hole 82131 can be engaged with the operating lever of the operable part for axial movement by the operable part throughout the axial movement of the slip ring.

Turning next to fig. 30-36, a retaining device according to another preferred embodiment of the present invention is shown. In this embodiment, the overall structure and arrangement of the syringe may be the same as or similar to those described in the foregoing embodiment, and will not be described in detail herein, only with respect to the differences from the holding device of the foregoing embodiment.

In the present embodiment, the operable member is arranged on the outer housing 32, and is configured as a push-type operable member. Referring to fig. 30, the linkage is held by a first inner push rod 33 within the outer housing. The storage container can be accommodated inside the first inner push rod 33.

In this embodiment, the linkage includes a limit mechanism configured to move in a vertical radial direction between an upper first position and a lower second position in response to movement of the operable member in the vertical radial direction between the locked position and the unlocked position, and a blocking mechanism configured to switch between a closed blocking state and an open non-blocking state in response to movement of the limit mechanism in the vertical radial direction between the upper first position and the lower second position.

It should be noted that, in this embodiment, references to "vertical", "horizontal", "upper", "lower", "top", "bottom", "left", "right", and the like are all described with respect to the axial direction X in which the syringe extends longitudinally, and are not absolute descriptions. For example, the vertical direction in the present embodiment refers to one specific radial direction (refer to the up-down direction in fig. 31) extending perpendicular to the axial direction X, and the horizontal direction refers to another specific radial direction (refer to the left-right direction in fig. 31) extending perpendicular to the axial direction X and perpendicular to the above-described horizontal direction.

Referring to fig. 31 and 32, the stopper mechanism of the present embodiment includes a snap ring 921 that can be engaged by the operable member such that when an operator presses down on the operable member, the snap ring moves downward in a vertical radial direction. The snap ring 921 can be fitted over the storage container 4 radially outside the storage container 4. The snap ring 921 includes a top portion 9211 engageable by the operable member and two arm portions extending from the top portion toward both sides in a circular arc shape as a whole, and an end portion 9213 of each of the two arm portions, which is away from the top portion, includes a guide groove 9214 for engaging the blocking mechanism and guiding the movement of the blocking mechanism. The guide groove 9213 extends in a horizontal radial direction.

Referring to fig. 35 and 35, in order to mount the snap ring 921, the first inner push rod 33 is formed with a catching groove 339 for receiving the snap ring 921, the catching groove matching the shape of the snap ring 921 such that the snap ring is movable in a vertical radial direction between a first position above (corresponding to a locked state of the holding device and a locked position of the operable member) and a second position below (corresponding to an unlocked state of the holding device and an unlocked position of the operable member) in the catching groove. The catching groove 921 includes two guide portions 337 extending in a vertical radial direction, each of which accommodates one of two end portions 9213 of the two arm portions of the snap ring 921, which are remote from the top, and allows the end portion to move up and down therein in the vertical radial direction.

Further, the catch 339 of the first inner push rod 33 comprises a first tongue 336 extending distally from a proximal surface of the catch extending perpendicular to the axial direction, which first tongue is located directly below 9211 the top of the snap ring 921 for holding an elastic element together with the top of the snap ring 921 (which will be described in detail below, not shown in the figures).

Specifically, the stopper mechanism further includes an elastic element that abuts between the hole 9212 opened in the bottom surface of the top of the snap ring 921 and the top surface of the first tongue 336, and is configured to be able to bias the snap ring 921 upward in a first position (corresponding to the locked state of the holding device and the locked position of the operable member). The elastic member may be an element such as a tension spring that can bias the snap ring upward when the operator does not press the operable member, or may be another elastic member that can achieve the same function.

Further, referring to fig. 31 and 33, the blocking mechanism includes two swing arms 9221 (each swing arm is generally crescent-shaped) that are arc-shaped as a whole, each swing arm being pivotably coupled to the first inner push rod 33 through a bottom side end portion thereof. For example, a bottom side end portion of each swing arm is provided with a hole 9222 penetrating the swing arm in the axial direction X, a step surface of the first inner push rod extending perpendicular to the axial direction X is provided with a hole 338 corresponding to the hole 9222 of each swing arm, and the hole 338 and the hole 9222 can be coupled by a member such as a pin rod, so that each swing arm can be pivotably coupled to the first inner push rod.

Further, a guide pin 9223 is provided at a substantially middle position of each swing arm, and is movable along a guide groove 9213 of the arm portion of the snap ring 921 located on the same side. When the snap ring 921 is in the upper first position (corresponding to the locking position of the holding means), each guide pin 9223 is located at the radially inner end of the corresponding guide groove 9213, so that the two swing arms 9221 together form a closed blocking state. In this blocking state, the two swing arms radially interfere with the storage container, thereby not allowing the storage container to be installed into the first interior pushrod or removed. When the operator presses the operable member such that the snap ring 921 moves downward (as indicated by an arrow at the top of the snap ring in fig. 31) to the second position (corresponding to the unlocking position of the holding means), the snap ring 921 moves the corresponding guide pin 9223 to the radially outer end of the guide groove 9213 through each guide groove 9213 (i.e., when the snap ring moves downward, the guide groove 9213 forces the guide pin 9223 therein to move to the radially outer end of the guide groove 9213, thereby converting the corresponding swing arm from closed to open), so that the two swing arms 9221 move radially outward (as indicated by an arrow at the swing arm in fig. 31, the two swing arms 9221 shown in the figure are in the open non-blocking state, wherein the guide pin is located at the outer end of the guide groove) to collectively form the open non-blocking state. In this non-blocking state, the two swing arms do not interfere with the storage container, allowing the storage container to be installed into the first interior pushrod or removed.

Preferably, the holding device referring to the present embodiment further includes an annular spacing element 923 for limiting the axial position of the blocking mechanism and the spacing mechanism. The stop element 923 is located distally of the blocking mechanism and stop mechanism to prevent the blocking mechanism and stop mechanism from moving distally off of the first inner push rod 33. Preferably, in this embodiment, the blocking mechanism is located distally of the spacing mechanism, and the spacing element 923 includes a proximally extending annular flange 9231 capable of distally abutting the two swing arms 9221, and a second tongue 9232 extending proximally beyond the annular flange 9231, the second tongue 9232 capable of distally abutting the top 9211 of the snap ring 921 when the snap ring 921 is in the first position above. Preferably, the second tongue 9232 may cooperate with a correspondingly disposed fifth through groove 3310 on the first inner push rod 33 such that the second tongue 9232 is received and retained in the fifth through groove 3310 when the spacing element 923 is mounted on the first inner push rod 33, fig. 30 schematically illustrates a state in which the spacing element 923 is mounted on the distal end of the first inner push rod 33.

Furthermore, it should be understood that the overall structure of the syringe described with respect to fig. 1-19, as well as other suitable features, may be applied singly or in combination to the embodiments described with respect to the other figures. Such as the principle, basic construction, drug delivery and injection procedures, etc. of a needleless injector. For example, the features, combinations of features, modes of action of features, etc. of the structure provided for ejecting the storage container (e.g., the seat 36 provided between the second inner push rod 34 and the proximal portion of the storage container, the third spring 37 provided between the seat and the second inner push rod) and the second annular groove 332 of the first inner push rod 33 and the mating rubber ring 38 (to avoid shaking of the storage container 4 in the first inner push rod 33 during operation) described with reference to fig. 15A to 15B and 17 to 19 for greater convenience of an operator removing the storage container from the syringe body 3 are equally applicable to other embodiments.

The invention also provides a needleless injector which comprises the injector main body and a storage container positioned in an outer shell of the injector main body, wherein the storage container can be removably installed in the injector and is matched with the injector for use. The syringe further comprises a retaining means as described in accordance with the various embodiments described above, the retaining means being configured to prevent the storage container from being mounted in or removed from the syringe in the locked state, or to allow the storage container to be mounted in or removed from the syringe.

The above-described embodiments of the present invention may be variously combined and/or modified, and the combined and/or modified results should also be regarded as embodiments of the present invention. The foregoing description of various embodiments of the invention has been presented for the purpose of illustration to one of ordinary skill in the relevant art. It is not intended that the invention be limited to the exact embodiment disclosed or as illustrated. As above, many alternatives and modifications of the present invention will be apparent to those of ordinary skill in the art in light of the above teachings. Thus, while some alternative embodiments have been specifically described, those of ordinary skill in the art will understand or relatively easily develop other embodiments. The present invention is intended to embrace all alternatives, modifications and variations of the present invention described herein and other embodiments that fall within the spirit and scope of the invention described above.

Claims

1. A holding device for a storage container (4) of a needleless injector, which storage container can be removably mounted in a needleless injector (1), characterized in that,

The holding device is configured to be switchable between a locked state, in which the holding device is capable of preventing the storage container from being mounted to or removed from a syringe body (3) of the needleless syringe, and an unlocked state, in which the holding device is capable of allowing the storage container to be mounted to or removed from the syringe body (3), wherein the holding device comprises:

an operable member operable by an operator to move between a locked position and an unlocked position of the operable member to switch the retaining device between the locked and unlocked states;

A linkage configured to switch between a first state and a second state in response to movement of the operable member between a locked position and an unlocked position,

Wherein when the operable member is in the locked position, the linkage is in the first state to prevent the storage container (4) from being mounted to or removed from the syringe body (3), and

Wherein when the operable member is in the unlocked position, the linkage is in the second state to allow the storage container (4) to be mounted to or removed from the syringe body (3).

2. The holding device according to claim 1, wherein the linkage is held by a tubular first inner push rod (33) within an outer housing of the syringe body, and wherein the storage container is receivable inside the first inner push rod (33).

3. The holding device according to claim 2, wherein the linkage mechanism includes:

A stop mechanism configured to move between a first position and a second position in response to movement of the operable member between the locked and unlocked positions, and

A blocking mechanism configured to switch between a blocking state and a non-blocking state in response to movement of the spacing mechanism between the first and second positions,

Wherein when the stopper mechanism is in the first position, the blocking mechanism is in a blocking state, the blocking mechanism in the blocking state being capable of interfering with the storage container in the radial direction to prevent the storage container from being mounted to or removed from the syringe body, and

Wherein when the spacing mechanism is in the second position, the blocking mechanism is in a non-blocking state, the blocking mechanism in the non-blocking state not interfering with the storage container to allow the storage container to be mounted to or removed from the syringe body.

4. A holding device according to claim 3, characterized in that the operable component is arranged on the outer housing (32) and is configured as a push-type operable component.

5. A holding device according to claim 3, characterized in that the operable component is arranged on the outer housing (32) and is configured as a push-type operable component.

6. A holding device according to claim 5, wherein the limit mechanism is configured to be movable in the axial direction (X) between a first position and a second position in response to movement of the operable member in the axial direction (X) between the locked and unlocked positions.

7. The holding device (5) according to claim 6, wherein the operable member (51) is mountable in a recess (321) of a circumferential side wall of an outer housing (32) of the syringe body (3), and

The operable member (51) is movable in the recess (321) relative to the outer housing along an axial direction (X) between the locked and unlocked positions.

8. The holding device (5) according to claim 7, wherein the operable component (51) comprises:

a base (511) extending in an axial direction (X);

An operator engagement portion (512) configured to extend outward in a radial direction from a radially outer surface of the base portion (511) and to be engageable by an operator to operate the operable member to move between the locked position and the unlocked position;

A sliding portion (513) configured to extend inward in the radial direction from a radially inner surface of the base portion (511) and capable of contacting a radially outer surface of a bottom wall (3211) of a recess (321) of the outer case (32) to move thereon in the axial direction (X), and

A protrusion (514) configured to extend inward in the radial direction from a radially inner surface of the sliding portion (513) and protrude toward a radially inner side of the outer housing (32) from an opening (32111) of a corresponding position of a bottom wall (3211) of the recess (321), the opening (32111) extending in the axial direction (X) and allowing the protrusion to move therein in the axial direction (X), and

Wherein the protrusion (514) is engageable with the linkage mechanism (52) to switch between a first state and a second state in response to movement of the protrusion (514) in the axial direction (X) in the opening (32111) of the recess (321).

9. The holding device (5) according to claim 8, wherein the sliding portion (513) of the operable member comprises a columnar member (5131) extending in the axial direction (X), and an end wall of the recess perpendicular to the axial direction (X) is provided with a hole (32121) aligned with the columnar member (5131), and

Wherein the holding device (5) further comprises a first spring (53) extending in the axial direction (X), the first spring comprising:

A first end (531) received and constrained within a hole (32121) of an end wall (3212) of the recess, and

A second end portion (532) which is fitted over the outer peripheral side of the columnar member (5131),

Wherein the first spring (53) is configured to be able to bias the operable member (51) toward the locking position by the columnar member (5131).

10. The holding device (5) according to claim 9, wherein the locked position of the operable member (51) is distally positioned with respect to the unlocked position,

Wherein the columnar member (5131) extends proximally from a proximal end surface of the sliding portion (513), the hole (32131) is opened in a proximal end wall (3212) of the recess (321), and

Wherein the first spring (53) is configured to bias the operable member (51) toward the distal locked position by the columnar member (5131).

11. The holding device (5) according to claim 10, further comprising a first guiding engagement portion extending in the axial direction (X) provided in a recess (321) of the outer housing (32),

Wherein the sliding portion of the operable member comprises a second guiding engagement portion extending in the axial direction (X), and

Wherein the first and second guide engagement portions are configured to cooperate with each other to guide movement of the sliding portion (513) of the operable member in the recess (321) of the outer housing.

12. The holding device (5) according to claim 11, wherein the first guiding engagement portion is configured to comprise at least one guiding post (322) fixedly arranged in a recess of the outer housing, the second guiding engagement portion is configured to comprise at least one through-going aperture (5132) opening in the sliding portion extending through in the axial direction (X), each through-going aperture being in a form fit with a corresponding guiding post (322) allowing the sliding portion (513) to move in the axial direction (X) by axial movement of each through-going aperture over the corresponding guiding post.

13. The holding device (5) according to claim 12, characterized in that both ends of the axial direction (X) of each guide post are respectively received and fixed in two U-shaped fixing pieces (323) extending outwardly in the radial direction from the radially outer surface of the bottom wall (3211) of the recess (321), the two U-shaped fixing pieces being configured to jointly restrict the movement of the guide post.

14. The holding device (5) according to claim 13, characterized in that the number of through-holes (5132) of the sliding part is two, both of which are open in a position close to both ends of the sliding part parallel to the axial direction (X), respectively, and correspondingly,

The number of the guide posts (522) is two, and the two guide posts are respectively positioned on the concave part and correspond to the circumferential positions of the two through holes of the sliding part.

15. The holding device (5) according to any one of claims 5 to 14, wherein the blocking mechanism (522) comprises a first annular member (5221) comprising a blocking portion (52211) which is separately provided with a through hole (52212) extending in the radial direction, the through hole accommodating a ball (5222) therein,

Wherein the diameter of the through hole (52212) is not smaller than the ball to allow the ball (5222) to move back and forth in the radial direction along the inner wall surface of the through hole, and

Wherein the through hole (52212) includes a first radially inner open end (522121), a second radially outer open end (522122), and an annular first flange (522123) extending from an inner wall surface of the through hole toward the interior of the through hole at the first open end, the first flange being sized to allow at least a portion of the ball (5222) to protrude radially inward from the first open end (522121) of the through hole (52212) while preventing the ball from continuing radially inward to move out of the through hole.

16. The holding device (5) according to claim 15, wherein the limit mechanism (521) includes a second annular member (5211) fitted over an outer peripheral side of the first annular member (5221), the second annular member being configured to be movable in the axial direction (X) between the first position and the second position in response to movement of the projection (514) in the axial direction (X) in an opening (32111) of the recess (321) of the outer casing,

Wherein the second annular member (5211) includes an annular second flange (52111) extending radially inward from an inner wall surface of the second annular member,

Wherein when the second annular member (5211) is in the first position, the second flange (52111) is aligned with the through-hole (52212) of the blocking mechanism (522) in the axial direction (X), and a radially inner surface of the second flange (52111) abuts against a ball (5222) in the through-hole (52212) of the blocking mechanism to force at least a portion of the ball to protrude radially inward from a first open end (522121) of the through-hole so as to interfere with each other in the radial direction with the storage container (4), and

Wherein when the second annular member (5211) is in the second position, the second flange (52111) is offset from the through-hole (52212) of the blocking mechanism in the axial direction (X) to allow the ball (5222) to move freely radially outward to a position no longer protruding radially inward from the first open end (522121) of the through-hole so as not to interfere with the storage container (4) any more.

17. The holding device (5) according to claim 15, wherein a proximal end of the first annular member (5221) is configured to be secured to a distal end of the first inner push rod (33).

18. The holding device (5) according to claim 17, wherein the first position is located distally with respect to the second position, wherein the stop mechanism (521) further comprises a second spring (5212) positioned between the first and second annular members and sleeved on the outer circumferential side of the first annular member,

Wherein the proximal end of the second spring (5212) abuts the distal end surface of the first inner push rod (33) and the distal end of the second spring abuts the proximal surface of the second flange (52111) of the second annular component (5211), and

Wherein the second spring (5212) is configured to bias the second annular member distally to the first position by a proximal end surface of the second flange (52111).

19. The holding device (5) according to claim 18, wherein the proximal end of the first annular member (5221) is formed with an external thread and the distal end of the first inner push rod (33) is formed with an internal thread that cooperates with the external thread of the first annular member (5221).

20. The holding device (5) according to claim 19, wherein a bevel (521111) is formed distally of the second flange (52111) of the second annular member (5211), wherein the ball is movable along the bevel (521111) of the second flange to a position no longer protruding radially inwards from the first open end of the through hole during proximal movement of the second annular member (5211) in the axial direction (X) from the first position to the second position.

21. The holding device (5) according to claim 20, wherein the second annular member (5211) further comprises a third flange (52112) located at a distal portion of the second annular member (5211), extending radially inward from an inner wall of the second annular member,

Wherein the second flange (52111) is located proximal to the third flange (52112) and the second flange is located between the third flanges forming a first annular groove (52113) configured to at least partially receive the ball (5222) when the second annular member is in the second position.

22. The holding device (5) according to claim 21, wherein the first annular member (5221) comprises a plurality of circumferentially distributed through holes (52212), each through hole accommodating the ball (5222) therein.

23. The holding device (5) according to claim 22, wherein a plurality of the through holes (52212) are arranged at equal intervals.

24. The holding device (5) according to claim 2, further comprising a base (36) for holding the storage container (4), the base being located proximally of the storage container and being configured to form-fit with a proximal end of the storage container for receiving and holding the proximal end of the storage container.

25. The holding device (5) according to claim 24, further comprising a third spring (37) configured to be positioned between the seat (36) and a tubular second inner push rod (34) within the outer housing (32) of the syringe body, the second inner push rod (34) being configured to be located proximally of the first inner push rod (33) and to be fixed to each other with the first inner push rod (33),

Wherein the third spring (37) is configured to bias the seat (36) distally along the axial direction (X).

26. The holding device (5) according to claim 25, wherein the second inner push rod (34) comprises:

A first axial extension (341) comprising an elongated first through slot (3411) open on the side wall extending in the axial direction (X), the first through slot extending to a distal end of the first axial extension, and

A second axial extension (342) extending distally from the distal end of the first axial extension,

Wherein a substantially middle position in the axial direction (X) of the first axial extension (341) is provided with an annular fourth flange (3412) extending radially inward from an inner wall surface of the first axial extension, and

Wherein the second axial extension (342) is for engaging a proximal end of the first inner push rod (33) to secure the first inner push rod (33) to each other.

27. The holding device (5) according to claim 26, wherein the base (36) comprises:

a third axial extension (361) the distal portion of which is provided with a distally extending tab (3611) corresponding to the first through slot (3411) of the second internal push rod (34) so as to be movable in the axial direction (X) within the first through slot, and

A fourth axial extension (362) extending distally from a distal end of the third axial extension (361).

28. The holding device (5) according to claim 27, characterized in that a proximal end of the third spring (37) abuts against a distal surface of a fourth flange (3412) of the second inner push rod (34) and a distal end of the third spring abuts against an inner step surface (364) extending perpendicular to the axial direction of a connection region between a third axial extension (361) and a fourth axial extension (362) of the base, whereby the base (36) can be biased distally in the axial direction (X) by the inner step surface.

29. The holding device (5) according to claim 28, wherein the reservoir (4) comprises a distally located reservoir region (41) and an annular engagement region (42) extending proximally from a proximal end of the reservoir region, the engagement region being held between a tab of a third axial extension (361) and a fourth axial extension (362) of the base, and

Wherein a proximal end of the engagement region (42) abuts an outer stepped surface (363) of a connection region between a third axial extension and a fourth axial extension of the base, extending perpendicular to the axial direction, such that the storage container can be pushed out of the syringe body by the third spring (37) following the base when operated by an operator to unlock the holding device (5).

30. The holding device (5) according to claim 26, characterized in that the second axial extension (342) of the second inner push rod (34) is provided with an internal thread and the proximal end of the first inner push rod (33) is provided with an external thread cooperating with the internal thread of the second axial extension.

31. The retaining device (5) of claim 26, wherein the first axial extension of the second inner pushrod (34) includes a plurality of the first through slots (3411), and the third axial extension of the base includes a plurality of tabs (3611) corresponding in location and number to the first through slots.

32. The holding device (5) according to claim 2, wherein an inner wall surface of the proximal end of the first inner push rod (33) is provided with a second annular groove (332) in which a rubber ring (38) contacting an outer peripheral side surface of the storage container is accommodated, the rubber ring being for preventing movement of the storage container.

33. The holding device (5) according to claim 15, wherein the first annular member (5221) further comprises an engagement portion (52214) distal to the blocking portion (52211) for engaging a piston rod (22) of the injection head (2) for mutual fixation with the piston rod.

34. The holding device (5) according to claim 33, wherein the engagement portion (52214) of the first annular member is formed with a third annular groove (52213) near the distal end of the first annular member, and

Wherein the proximal end of the piston rod is provided with a resilient snap-fit portion (221) extending proximally in the axial direction (X), which snap-fit portion is snapable to a distal end face (522131) of the third annular groove, such that the piston rod (22) and the first annular member (5221) are fixed to each other.

35. The holding device according to claim 6, characterized in that the limiting mechanism comprises a slip ring part (821) which is arranged in the first inner push rod (33) and which is sleeved on the storage container (4),

The slip ring component is movable in the axial direction (X) relative to the storage container between a first position and a second position in response to movement of the operable component in the axial direction (X) between the locked position and an unlocked position, wherein the slip ring component comprises:

A distal cylindrical portion (8212) having a peripheral side wall provided with a projection (8213) capable of engaging the operable member to move in an axial direction in a corresponding groove provided in an inner wall surface of the first inner push rod (33) under the drive of the operable member to guide the movement of the slip ring member (821) in the axial direction, and

A proximal frustoconical portion (8211) for engaging the blocking mechanism (822) to switch the blocking mechanism between the blocking and non-blocking states.

36. The retention device of claim 35, wherein the blocking mechanism is positioned proximal to the spacing mechanism and comprises:

An elastic ring piece member (8221) arranged in the first inner push rod (33) and sleeved on the storage container (4), the elastic ring piece member being engageable with a truncated cone portion (8211) of the slip ring member (821) on the distal side, and

A mounting member (8232) for fixedly mounting the elastic ring piece member (8231) to the first inner push rod (33), the mounting member comprising a distal tubular element (82221) and a proximal annular stop element (82321),

Wherein the tubular element (82221) is clamped in a corresponding fixing groove in the first inner push rod (33) and can be fixedly connected with the elastic ring piece part (8221), and

Wherein the annular stop element (82821) is arranged adjacently proximal to the tubular element for limiting axial movement of the tubular element.

37. The holding device according to claim 36, wherein the elastic ring-like member (8221) comprises a plurality of elastic elements (82211) arranged consecutively in the circumferential direction, each elastic element (82211) comprising:

A securing portion (822111) radially outward for securing the resilient element to the distal edge of the tubular element (82221), and

A deformable portion (822112) capable of being elastically deformed such that an angle (R) between the deformable portion and the fixed portion is switched between a first angle and a second angle.

38. The holding device according to claim 37, wherein when the slip ring member (821) of the stop mechanism is in the first distal position, the frustoconical portion (8211) does not engage the annular member (8221), an angle between the deformable portion (822112) and the fixed portion (822111) of each of the plurality of elastic elements (82311) being a first angle, when a radially inner end of the deformable portion (822112) contacts and interferes with the storage container;

when the slip ring part (821) of the limit mechanism moves proximally to a second position, the truncated conical portion (8211) biases the deformable portion of each of the plurality of elastic elements (82211) radially outward such that an angle between the deformable portion (822112) and the fixed portion (822111) of each of the plurality of elastic elements (82211) is converted from the first angle to a second angle, when a radially inner end of the deformable portion (822112) does not contact the storage container, and

Wherein, the first contained angle is greater than the second contained angle.

39. The holding device according to claim 38, wherein radially inner ends of the deformable portions (822112) of the plurality of elastic elements (82311) together form an opening (82312) of the elastic annular member (8221),

Wherein, when the included angle between the deformable portion (822112) and the fixed portion (822111) of each of the plurality of elastic elements (82311) is a first included angle, the opening (8232) has a first diameter;

wherein when the angle between the deformable portion (822112) and the fixed portion (822111) of each of the plurality of elastic elements (82311) is a second angle, the opening (82212) has a second diameter, and

Wherein the second diameter is greater than the first diameter.

40. The holding device according to claim 35, wherein the tab (8233) comprises a hole (82131) configured to be engaged by a lever of the operable component.

41. The holding device according to claim 40, characterized in that a second through slot (333) is provided on the first inner push rod (33) in a position corresponding to the projection, which second through slot (333) allows the hole (82131) of the projection to be exposed to the operating rod when the slip ring part (821) is moved between the first and second position.

42. The holding device according to claim 1, characterized in that the cylindrical portion (8212) of the slip ring part comprises two said lugs (8213) arranged symmetrically, and

Correspondingly, the first inner push rod (33) comprises two second through slots (333) which are symmetrically arranged.

43. The holding device according to claim 2, characterized in that the operable component is arranged on the outer housing (32) and is configured as a push-type operable component, and

The linkage includes a swing link and a resilient element housed inside and held by the first inner push rod (33).

44. The holding device according to claim 43, wherein the circumferential side wall of the first inner push rod (33) is provided with a through groove near the distal end for receiving and holding the swing rod and the elastic element, wherein the swing rod is pivotally mounted to the through groove.

45. The holding device of claim 44, wherein said swing link includes a pin disposed at a substantially intermediate position of said swing link, said swing link being mounted to said through slot by said pin,

Wherein the through slot comprises two opposite side walls extending in an axial direction (X), each side wall having a mounting hole formed therein for receiving and securing an end of the pin, and

The swing rod can rotate around the pin rod in the through groove.

46. The retaining device of claim 45, wherein the rocker includes a first leg proximal to the pin and a second leg distal to the pin,

Wherein one of the first and second legs is switchable from a first state radially interfering with the storage container (4) to a second state not interfering with the storage container (4) in response to the operable member being pressed by an operator to move from the locked position towards the unlocked position.

47. The holding device according to claim 46, wherein the second leg (712) of the swing lever (71) is switchable from a first state radially interfering with the storage container (4) to a second state not interfering with the storage container (4) in response to the operable member being pressed by an operator for movement from the locked position towards the unlocked position, and

Wherein the second leg (712) of the swing link (71) comprises a protrusion (713) extending from a radially inner surface of the second leg in a radially inner direction, the protrusion being configured to be able to radially interfere with the storage container (4) when the second leg (712) of the swing link (71) is in the first state and to be able to not interfere with the storage container (4) when the second leg is in the second state.

48. The holding device according to claim 47, characterized in that the elastic element (72) is configured to bias the second leg (712) of the pendulum (71) towards a first state radially interfering with the storage container (4).

49. The retaining device according to claim 48, characterized in that the through-slot of the first inner push rod for receiving and retaining the pendulum rod is a third through-slot (334), the third through-slot (334) comprising a proximal first portion (3342) and a distal second portion (3343) having a smaller width than the first portion,

Wherein the elastic element (72) is arranged between a radially outer surface of the second leg (712) of the swing link (71) and a radially inner surface of a circumferential side wall of the first inner push rod (33) at the second portion (3343) of the third through groove (334), and is capable of biasing the second leg (712) of the swing link (71) in a radially inward direction toward a position radially interfering with the storage container (4).

50. The holding device according to claim 49, wherein the operable member is capable of engaging the first leg (711) of the swing link (71) to allow the first leg (711) of the swing link (71) to move in a radially inward direction when an operator presses the operable member such that the swing link (71) pivots about a pin against the biasing force of the resilient element (72) to a position where the protrusion (713) of the second leg (712) of the swing link (71) does not interfere with the storage container (4).

51. The holding device according to claim 50, wherein the second portion (3343) of the third through-slot (334) comprises a bottom wall (3344) configured such that the distal end of the second leg (712) of the swing link (71) can overlap the bottom wall (3344) when the second leg (712) is in the first state, and

Wherein the bottom wall (3344) does not contact the projection (713) of the swing link (71).

52. The holding device according to claim 47, characterized in that the first leg (711) and the second leg (712) of the pendulum rod (71) extend substantially parallel to each other.

53. The holding device according to claim 46, wherein the first leg (711 ') of the swing lever (71') is switchable from a first state radially interfering with the storage container (4) to a second state not interfering with the storage container (4) in response to a movement of the operable member pressed by an operator from the locked position towards the unlocked position, and

Wherein the proximal end of the first leg (711 ') of the swing link (71') is configured to radially interfere with the storage container (4) when the first leg (711 ') of the swing link (71') is in the first state and to not interfere with the storage container (4) when the first leg is in the second state.

54. The holding device according to claim 53, characterized in that the elastic element (72 ') is configured to bias the second leg (712 ') of the pendulum rod (71 ') in a radially outer direction such that the pendulum rod (71 ') pivots about a pin rod in a position in which a proximal end of the first leg (711 ') of the pendulum rod is able to radially interfere with the storage container (4).

55. The retaining device of claim 54, wherein the through slot of the first inner pushrod for receiving and retaining the pendulum rod is a fourth through slot (335), the fourth through slot (335) comprising a proximal first portion (3352) and a distal second portion (3353),

Wherein the first portion (3352) of the fourth slot (335) allows the first leg (711 ') of the swing link (71') to pass therethrough and radially interfere with the storage container (4), and

Wherein the second portion (3353) of the fourth slot (335) is provided with a bottom wall, the elastic element (72 ') being held between this bottom wall and a radially inner surface of the second leg (712 ') of the swing lever (71 ').

56. The holding device according to claim 55, wherein the operable member is adapted to engage the second leg (712 ') of the pendulum rod (71'), such that when an operator presses the operable member, the second leg (712 ') of the pendulum rod (71') is adapted to move radially inwards against the biasing force of the resilient element (72 '), such that the pendulum rod (71') pivots about a pin rod to a position in which the proximal end of the first leg (711 ') of the pendulum rod (71') does not interfere with the storage container (4).

57. The holding device according to claim 53, characterized in that an obtuse angle is formed between the first leg (711 ') and the second leg (712 ') of the pendulum rod (71 ') in the radially inner direction.

58. The holding device according to claim 44, characterized in that one or more through slots are provided in the circumferential side wall of the first inner push rod (33) in the circumferential direction, each of which accommodates and holds the swing rod and the elastic element.

59. The retaining device of claim 43, wherein the resilient element is a tension spring.

60. A holding device according to claim 3, characterized in that the operable component is arranged on the outer housing (32) and is configured as a push-type operable component,

Wherein the limit mechanism is configured to move in a vertical radial direction between an upper first position and a lower second position in response to movement of the operable member in the vertical radial direction between the locked position and the unlocked position, and

Wherein the blocking mechanism is configured to be switchable between a closed blocking state and an open non-blocking state in response to movement of the spacing mechanism between the first and second positions.

61. The holder according to claim 60, wherein the stop mechanism includes a snap ring (921) engageable by the operable member such that the snap ring moves downwardly when an operator presses down on the operable member.

62. The holding device according to claim 61, characterized in that the snap ring (921) can be placed over the storage container (4) radially outside the storage container,

Wherein the snap ring (921) comprises a top portion (9211) engageable by the operable member and two arm portions extending from the top portion toward both sides and having a circular arc shape as a whole, an end portion (9213) of each of the two arm portions, which is away from the top portion, comprises a guide groove (9214) for engaging the blocking mechanism and guiding movement of the blocking mechanism, and

Wherein the guide groove (9213) extends in a horizontal radial direction.

63. The holding device according to claim 62, wherein the first inner push rod (33) is formed with a clamping groove (339) for receiving the clamping ring (921), the clamping groove matching the shape of the clamping ring such that the clamping ring is movable in the clamping groove in a vertical radial direction between a first position and a second position,

Wherein the clamping groove comprises two guide portions (337) extending in a vertical radial direction, each of the guide portions accommodating one of two end portions of the two arm portions of the snap ring (921) distant from the top portion and allowing the end portion to move up and down therein in the vertical radial direction.

64. The retaining device of claim 63, wherein the detent (339) of the first inner push rod includes a first tongue (336) extending distally from a proximal surface of the detent extending perpendicular to the axial direction, the first tongue being located below (9211) the top of the snap ring (921).

65. The retaining device of claim 64, wherein the stop mechanism further comprises a resilient element that abuts between a hole (9212) opened in a bottom surface of the top of the snap ring (921) and a top surface of the first tongue (336) and is configured to bias the snap ring (921) upward.

66. The holding device according to claim 65, wherein the blocking mechanism comprises two swing arms (9221) of an overall circular arc shape, each swing arm being pivotably coupled to the first inner push rod (33) by its bottom side end.

67. The holding device according to claim 66, characterized in that the substantially middle position of each swing arm is provided with a guide pin (9223) which is movable along a guide groove (9213) of the arm of the snap ring (921) on the same side,

Wherein, when the snap ring (921) is in the upper first position, each guide pin (9223) is located at a radially inner end of the corresponding guide slot (9213) such that the two swing arms (9221) together form a closed blocking state in which they radially interfere with the storage container, and

Wherein, when an operator presses the operable member such that the snap ring (921) moves downward to the second position, the snap ring (921) moves the corresponding guide pin (9223) to the radially outer end of each guide groove (9213) through each guide groove (9213), so that the two swing arms (9221) move radially outward to a non-blocking state that forms an opening together, in which the two swing arms do not interfere with the storage container.

68. The retaining device of claim 67, further comprising an annular stop element (923) for limiting the axial position of the blocking mechanism and the stop mechanism.

69. The retaining device of claim 68, wherein the stop element (923) is located distally of the blocking mechanism and the stop mechanism to prevent distal movement of the blocking mechanism and the stop mechanism out of the first inner push rod (33).

70. The retaining device of claim 69, wherein the blocking mechanism is distal to the spacing mechanism,

The limiting element (923) comprises:

a proximally extending annular flange (9231) capable of distally resisting the two swing arms (9221), and

A second tongue (9232) extending proximally beyond the annular flange (9231), the second tongue (9232) being configured to distally abut a top (9211) of the snap ring (921) when the snap ring (921) is in the first position above.

71. A needleless injector (1) comprising an injector body (3) and a storage container (4) within an outer housing (32) of the injector body, the storage container being removably mountable in the needleless injector,

Wherein the syringe body (3) comprises the outer housing (32) and a tubular first inner push rod (33) within the outer housing, characterized in that the needleless syringe further comprises:

the holding device for the storage container of any one of claims 1-70, the holding device being configured to prevent the storage container from being installed into or removed from the needleless syringe in a locked state, or to allow the storage container to be installed into or removed from the needleless syringe.

72. A needleless injector (1) as in claim 71, further comprising an injection head (2) removably mountable to the injector body, a distal end of the injection head comprising injection micropores.

73. Needleless injector (1) as in claim 71, wherein the storage container (4) is a cartridge.

74. The needleless injector (1) of claim 71, wherein,

The linkage is held by a tubular first inner push rod (33) within an outer housing (32) of the syringe body, and the storage container can be accommodated inside the first inner push rod (33),

Wherein, first inside push rod (33) is including forming first fretwork portion (331) on circumference lateral wall to outer casing (32) include with first fretwork portion is in second fretwork portion (322) of circumference direction alignment, first fretwork portion (331) with second fretwork portion (322) form the visual window that supplies the operator to observe the storage container jointly.

75. A needleless injector (1) as in claim 74, wherein the operable member (51) is mountable to a recess (321) of a circumferential side wall of an outer housing (32) of the injector body (3), and the first and second hollowed-out portions (331, 322) have an elongated shape extending in the axial direction (X), and

Wherein the second hollowed-out part is positioned at the near side of the concave part (321).

76. The needleless injector (1) of claim 75, further comprising a cover (6) engageable with an outer housing (32) of the needleless injector to cover the recess (321) and the second hollowed out portion (322), and

Wherein the cover (6) comprises a window (61) through which an operator-engaging portion of the operable member can be exposed to an operator when the cover is closed onto the outer housing (32).